Summary of the invention
The objective of the invention is to overcome the prior art deficiency and a kind of Chinese medicine of treating the deficiency myocardial blood supply syndrome is provided.
Another object of the present invention is to provide a kind of treatment deficiency myocardial blood supply syndrome preparation method of Chinese medicine.
The present invention adopts following technical scheme:
A kind of Chinese medicine of treating the deficiency myocardial blood supply syndrome and preparation method thereof.This Chinese medicine is to be processed by Herba Ephedrae, Gypsum Fibrosum, Semen Sinapis Albae, Rhizoma Zingiberis, Radix Aconiti Lateralis Preparata, the Rhizoma Atractylodis Macrocephalae, Herba Asari, Fructus Aurantii, Colla Corii Asini, Radix Ophiopogonis, Radix Angelicae Sinensis, Radix Panacis Quinquefolii, the Radix Rehmanniae, Radix Ginseng Rubra, Herba Epimedii, Fructus Lycii, Radix Platycodonis, Fructus Corni, the Radix Astragali and Cortex Cinnamomi.
A kind of Chinese medicine composition of treating the deficiency myocardial blood supply syndrome is to be prepared from following crude drug, is weight portion: 3 ~ 10 parts in Herba Ephedrae, 9 ~ 30 parts of Gypsum Fibrosum, 3 ~ 9 parts of Semen Sinapis Albaes; 1 ~ 3 part of Rhizoma Zingiberis, 3 ~ 9 parts of Radix Aconiti Lateralis Preparata, 6 ~ 12 parts of the Rhizoma Atractylodis Macrocephalaes, 5 ~ 15 parts of Herba Asaris, 3 ~ 9 parts of Fructus Aurantiis; 6 ~ 12 parts in Colla Corii Asini, 6 ~ 15 parts of Radix Ophiopogonis, 5 ~ 12 parts of Radix Angelicae Sinensis, 2 ~ 8 parts of Radix Panacis Quinquefoliis; 3 ~ 9 parts in the Radix Rehmanniae, 3 ~ 9 parts of Radix Ginseng Rubra, 3 ~ 9 parts of Herba Epimedii, 5 ~ 15 parts of Fructus Lycii; 5 ~ 10 parts of Radix Platycodoniss, 6 ~ 12 parts of Fructus Corni, 5 ~ 10 parts of the Radixs Astragali, 1 ~ 3 part of Cortex Cinnamomi.
The Chinese medicine composition of described treatment deficiency myocardial blood supply syndrome in the preferred scheme, is to be prepared from following crude drug, is weight portion: 5 ~ 8 parts in Herba Ephedrae, 12 ~ 20 parts of Gypsum Fibrosum; 4 ~ 8 parts of Semen Sinapis Albaes, 1.5 ~ 2 parts of Rhizoma Zingiberiss, 4 ~ 6 parts of Radix Aconiti Lateralis Preparata, 8 ~ 10 parts of the Rhizoma Atractylodis Macrocephalaes, 8 ~ 12 parts of Herba Asaris; 4 ~ 6 parts of Fructus Aurantiis, 8 ~ 10 parts in Colla Corii Asini, 8 ~ 12 parts of Radix Ophiopogonis, 6 ~ 10 parts of Radix Angelicae Sinensis, 4 ~ 6 parts of Radix Panacis Quinquefoliis; 4 ~ 8 parts in the Radix Rehmanniae, 4 ~ 8 parts of Radix Ginseng Rubra, 4 ~ 8 parts of Herba Epimedii, 8 ~ 12 parts of Fructus Lycii; 6 ~ 8 parts of Radix Platycodoniss, 8 ~ 10 parts of Fructus Corni, 7 ~ 9 parts of the Radixs Astragali, 1.5 ~ 2 parts of Cortex Cinnamomis.
The Chinese medicine composition of described treatment deficiency myocardial blood supply syndrome in the preferred scheme, is to be prepared from following crude drug, is weight portion: 6 parts in Herba Ephedrae, 18 parts of Gypsum Fibrosum, 6 parts of Semen Sinapis Albaes; 1.8 parts of Rhizoma Zingiberiss, 5 parts of Radix Aconiti Lateralis Preparata, 9 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Herba Asaris, 5 parts of Fructus Aurantiis, 9 parts in Colla Corii Asini; 10 parts of Radix Ophiopogonis, 8 parts of Radix Angelicae Sinensis, 5 parts of Radix Panacis Quinquefoliis, 6 parts in the Radix Rehmanniae, 6 parts of Radix Ginseng Rubra, 6 parts of Herba Epimedii; 10 parts of Fructus Lycii, 7 parts of Radix Platycodoniss, 9 parts of Fructus Corni, 8 parts of the Radixs Astragali, 1.8 parts of Cortex Cinnamomis.
The method for preparing of the Chinese medicine composition of described treatment deficiency myocardial blood supply syndrome, step is following:
(1) each crude drug outside Gypsum Fibrosum and the Colla Corii Asini is pulverized, crossed the 90-100 mesh sieve, get fine powder;
(2) with Gypsum Fibrosum and step (1) gained fine powder mix homogeneously, place in the muslin bag, the use temperature is that 20 ℃ cold water soaked 6-8 hour, and water consumption is 6-7 a times of said fine powder weight;
(3) be heated to boiling, continue to take out muslin bag after 50 minutes, gained liquid gets concentrated solution through being concentrated into the 1/2-1/3 of original volume;
(4) with the Colla Corii Asini molten, join step (3) gained concentrated solution, sterile packaged after 105-120 ℃ of antibacterial 10-20 minute promptly gets Chinese medicine composition.
Described method for preparing, preferably scheme is: pulverize the back in the step (1) and cross 95 mesh sieves, get fine powder.
Described method for preparing, preferred scheme is: step (2) was soaked 7 hours with cold water, and water consumption is 6.5 times of said fine powder weight.
Described method for preparing, preferred scheme is: step (4) promptly gets in 110 ℃ of antibacterials sterile packaged after 15 minutes.
The present invention compared with prior art, it is reliable to have curative effect, the advantage that has no side effect, production technology is simple.
Herba Ephedrae is come from Shennong's Herbal, hot, little hardship, temperature.Return lung, urinary bladder channel.Its effect is diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.Herba Ephedrae is the medicine of lung qi dispersing diuresis, and this article diaphoresis diuretic helps the edema that dissipates, and is equal to usefulness with Rhizoma Zingiberis, the Rhizoma Atractylodis Macrocephalae;
Semen Sinapis Albae comes from " must join book on Chinese herbal medicine ", warm in nature, acrid in the mouth, nontoxic.Function warming the lung eliminating phlegm promoting the circulation of QI, the resolving mass and removing the obstruction of the collateral pain relieving cures mainly cold-phlegm and breathes with cough, distending pain in the chest and hypochondrium, the expectorant meridians that stagnate, joint numbness, pain, phlegm-damp oozing in the body, carbuncle of yin nature toxic swelling;
Radix Aconiti Lateralis Preparata, Da Xin, big heat, poisonous, its function is recuperating depleted YANG and rescuing the patient from collapse, warming and recuperating the spleen and kidney, dispersing cold for relieving pain.The big heat of Da Xin, warming YANG is by cold.Radix Aconiti Lateralis Preparata and Rhizoma Zingiberis match and treat cold Shaoyang disease, and yin-cold excess, yang-energy is desired to take off, and the stomachache diarrhea is arranged, and extreme cold of the limbs, faint and thready pulse are wild;
The Rhizoma Atractylodis Macrocephalae, bitter, sweet, temperature.Return spleen, stomach warp.Invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.Be used for that insufficiency of the spleen lack of appetite, abdominal distention are had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement; Rhizoma Atractylodis Macrocephalae the spleen strengthening and damp drying, the kind outer expectorant water of flesh side film of dispelling of Semen Sinapis Albae, two medicines share, and spleen invigorating dissipating fluid-retention is then treated the card of fluid-retention in the chest and hypochondrium.
Herba Asari, effect is the cold expelling that induces sweat, wind-expelling pain-stopping is sensible, warming the lung to resolve fluid-retention, analgesic, diuresis, analgesia, tranquilizer are controlled headache, diaphoresis is arranged, eliminate the phlegm.
Fructus Aurantii, effect is regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.Be used for the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion stops in the phlegm retention; Gastroptosis, proctoptosis, sub-official's prolapsus.
Colla Corii Asini is enriched blood; Hemostasis; YIN nourishing; Moisturize.
Radix Ophiopogonis, sweet; Little hardship; Cold, nourishing YIN and moistening the lung; Reinforcing stomach reg fluid; Relieving restlessness clears away heart-fire.Dryness of the lung dry cough is spitted blood, spitting of blood, and consumptive lung disease, lung abscess, the asthenia dysphoria with smothery sensation is quenched one's thirst, and hinder in calentura Tianjin, dry mouth and throat, constipation.
Radix Angelicae Sinensis, warm in nature, sweet in the mouth, suffering.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Radix Panacis Quinquefolii, Radix Panacis Quinquefolii is cold in nature, bitter in the mouth, little sweet, GUIXIN, lung, kidney channel have the effect that boosting qi and nourishing yin, clear people promote the production of body fluid.Put down in writing according to clear " Bencao Congxin ": " relieving restlessness is tired for Radix Panacis Quinquefolii tonifying the lung pathogenic fire reducing, born fluid.Empty and have fiery person suitable.”
The Radix Rehmanniae, Radix Rehmanniae sweet in the mouth, hardship, cold in nature.GUIXIN, liver, lung meridian.Heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, the incised wound stasis of blood, removing heat from blood, hemostasis; Herba Epimedii, hot, sweet, temperature.Return liver, kidney channel to cure mainly function: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling; Radix Ginseng Rubra, strongly invigorating primordial QI, multiple arteries and veins takes off nourishing qi to stop admittedly.Be used for weak body and prostration, cold extremities faint pulse, QI failing to control blood, metrostaxis; Heart failure, the effect of cardiogenic shock.Also have QI invigorating arranged, YIN nourishing, beneficial blood, promote the production of body fluid, heart tonifying, be good for the stomach, effect such as calmness;
Fructus Lycii, its sweet in the mouth, property are put down has the effect of the liver and the kidney tonifying, says in the Compendium of Material Medica that " obey hard muscles and bones for a long time, it is not old to make light of one's life by commiting suicide, cold-resistant summer-heat." traditional Chinese medical science commonly used it treat hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, forgetful, dizzy, many tears of blurred vision, quench one's thirst, disease such as seminal emission;
Radix Platycodonis comes from Shennong's Herbal: acrid in the mouth, tepor.Cure mainly chest and hypochondrium such as lancination, abdominal distention, borborygmus are faint, the gas of throbbing with fear in terror;
Fructus Corni, sour, puckery, tepor.Return liver, kidney channel.Liver and kidney tonifying, restrain astringent or styptic treatment for spontaneous sweating, controlling nocturnal emission with astringent drugs reducing urination leukorrhagia stopping only collapses, hidroschesis, also have promoting the production of body fluid to quench thirst in addition.Be used for soreness of waist and knee joint, dizziness and tinnitus, forgetful, emission and spermatorrhea, enuresis frequent micturition, the bleeding not during menses menoxenia, profuse sweating collapse, interior-heat are quenched one's thirst;
The Radix Astragali, property is sweet, tepor.Return lung, spleen, liver, kidney channel.There are benefiting QI for strengthening the superficies, arresting sweating to take off, hold in the palm the effect of skin ulcer granulation promoting, inducing diuresis to remove edema admittedly.It is weak generally to be used to treat the deficiency of vital energy, sinking of QI of middle-JIAO, and the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.
Cortex Cinnamomi, acrid in the mouth, sweet, hot in nature.Effect: warming middle-JIAO YANG invigorating, dispersing cold for relieving pain.
The traditional Chinese medical science is thought deficiency of heart-QI, and the kidney yang decline is the most important pathogenesis of primary disease.Kidney yang is at sun originally, heart kidney
Yang deficiency then directly has influence on the speed of heart beating, so square benefiting qi and raising yang, invigorating blood circulation is tired.The Radix Astragali, Radix Panacis Quinquefolii, Radix Ginseng Rubra reinforce functional activities of the heart in the side; Herba Epimedii, Cortex Cinnamomi, Fructus Lycii kidney invigorating and YANG supporting; Colla Corii Asini, Radix Angelicae Sinensis nourishing YIN and supplementing blood; Herba Ephedrae, Radix Aconiti Lateralis Preparata, Fructus Aurantii have excited sinuatrial node, raising sinuatrial node frequency, improve the function of sinuatrial node surrounding tissue; The Radix Rehmanniae can improve myocardium dirty function and blood circulation; Radix Ophiopogonis, the scorching impairment of YIN of Fructus Corni system, second the same usefulness of YIN nourishing and warming YANG makes interdependence between yin and yang, then YANG promoting growth while YIN promoting generation.All medicines share benefiting qi and raising yang, invigorate blood circulation that it is tired to dispel, and have the obvious function of improving the sinuatrial node heart rate.
The specific embodiment
Specify technical scheme of the present invention below in conjunction with embodiment and Test Example, but protection domain is not by this restriction.
Embodiment:A kind of Chinese medicine composition of treating the deficiency myocardial blood supply syndrome, crude drug are respectively Herba Ephedrae 6g, Gypsum Fibrosum 18g, Semen Sinapis Albae 6g, Rhizoma Zingiberis 1.8g, Radix Aconiti Lateralis Preparata 5g; Rhizoma Atractylodis Macrocephalae 9g, Herba Asari 10g, Fructus Aurantii 5g, Colla Corii Asini 9g, Radix Ophiopogonis 10g; Radix Angelicae Sinensis 8g, Radix Panacis Quinquefolii 5g, Radix Rehmanniae 6g, Radix Ginseng Rubra 6g, Herba Epimedii 6g; Fructus Lycii 10g, Radix Platycodonis 7g, Fructus Corni 9g, Radix Astragali 8g, Cortex Cinnamomi 1.8g.
The method for preparing of aforementioned Chinese medicine composition, step is following:
(1) each crude drug outside Gypsum Fibrosum and the Colla Corii Asini is pulverized, crossed 95 mesh sieves, get fine powder;
(2) with Gypsum Fibrosum and step (1) gained fine powder mix homogeneously, place in the muslin bag, the use temperature is that 20 ℃ cold water soaked 7 hours, and water consumption is 6.5 times of said fine powder weight;
(3) be heated to boiling, continue to take out muslin bag after 50 minutes, gained liquid gets concentrated solution through being concentrated into 1/4 of original volume;
(4) with the Colla Corii Asini molten, join step (3) gained concentrated solution, in 110 ℃ of antibacterials sterile packaged after 15 minutes, promptly get Chinese medicine composition.
Model case:
Zhao, the man, 57 years old, here first visit over 2010, originally the patient just has a dizzy spell, sensation of oppression over the chest with shortness of breath, faints three times after the outbreak afterwards, faints several minutes at every turn.Electrocardiogram shows: sinus bradycardia, and 40 times/min of the rhythm of the heart, 24 hr Ambulatory EKG Monitoring show that the sinus bradycardia and the alternately appearance of overrunning do not have obviously behind the western medicine and improve.Take present embodiment gained Chinese medicine, each 1 dose, once a day, taken 3 courses of treatment continuously, though improving not obvious all diseases, heart rate obviously alleviates, continue and obey 2 courses of treatment, heart rate reaches 62 times/min, and all diseases disappear, and the check electrocardiogram is normal, and the 24h ambulatory electrocardiogram is normal.
Money, the woman, 40 years old, the tachypnea of patient's cardiopalmus, myasthenia of limbs is not warm, spinal column cold type of pain, nocturia frequency.Once outbreak is fainted three times, each approximate number minute.Purplish tongue is secretly fat, and stringy and thready pulse is slow.Electrocardiogram shows: the slow 50 times/min card of hole belongs to deficiency of heart-YANG and kidney-YANG, and the blood vessels addiction stagnates.Take present embodiment gained Chinese medicine after 3 courses of treatment, heart rate maintains 50 ~ 70 times/min, and remission was followed up a case by regular visits to 4 months, and the faintness symptom does not occur again.
Experimental example:The present invention treats the Chinese medicine of deficiency myocardial blood supply syndrome in 2006 to 2011 treatment patient 100 examples, and basic document is following: among the 100 routine patients, and women's 48 examples, male's 52 examples, the age, disease time was many in 2-4 years between 38-62 years old.Matched group is taken the other treatment morbid state cardiopathic medicine of antrum (Chinese medicine, Western medicine).Table 1: take embodiment 1 product 38-62 deficiency myocardial blood supply patient treatment result.
|
Experimental group
|
Matched group
|
The example number |
100 |
20 |
Male's example number |
52 |
10 |
Women's example number |
48 |
10 |
Age (year) |
38-62 |
38-62 |
Clinical cure example number |
72 |
5 |
Effective routine number |
27 |
11 |
Invalid routine number |
1 |
4 |
Total effective rate |
99% |
80% |
Therapeutic effect: cure 72 examples (72%), effective 27 examples (27%), invalid 1 example (1%), total effective rate 99%.Effect obviously is superior to matched group.Diagnostic criteria: insufficient symptom internal organs confession such as the heart relevant with bradycardia, brain appears and in the patient, and like ictal dizzy, amaurosis, weak etc., severe patient can be fainted.Electrocardiogram mainly shows and comprises: 1. continue and significant sinus bradycardia (below the 50 times/min), and medicine causes no thanks to; 2. sinus arrest and sinoatrial block; 3. sinoatrial block and atrioventricular block exist simultaneously; 4. bradycardia, tachycardia syndrome.Instructions of taking: each 1 dose, once a day, 10 days is a course of treatment.Self-induction symptom and physical change of spirit thereof are as shown in table 2 during taking, and hence one can see that, and experimental group obviously is superior to matched group.