CN102526516B - Chinese medicine for treating chronic heart failure and preparation method thereof - Google Patents
Chinese medicine for treating chronic heart failure and preparation method thereof Download PDFInfo
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- CN102526516B CN102526516B CN201110426334.1A CN201110426334A CN102526516B CN 102526516 B CN102526516 B CN 102526516B CN 201110426334 A CN201110426334 A CN 201110426334A CN 102526516 B CN102526516 B CN 102526516B
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Abstract
The invention discloses a Chinese medicine for treating chronic heart failure and a preparation method thereof. The preparation method is characterized by comprising the following steps of: mixing 10-30 parts by mass of prepared prepared common monkshood daughter root, 10-15 parts by mass of cassia twig, 10-15 parts by mass of capsicum annuum, 30-60 parts by mass of astragalus, 10-15 parts by mass of heterophylly falsestarwort root, 15-20 parts by mass of indian buead, 15 parts by mass of oriental waterplantain rhizome, 15 parts by mass of corn silk, 15 parts by mass of pepperweed seed, 15 parts by mass of hiraute shiny bugleweed herb, 15 parts by mass of fruit of princesplume ladysthumb and 15-30 parts by mass of motherwort herb; and mixing the components, grinding into powder to obtain a capsule or decocting to obtain a medicament. The Chinese medicine has the advantages of short treatment course, quick response, no medicament resistance and no toxic or side effect.
Description
Technical field
The present invention relates to technical field of Chinese medicines, specifically treat Chinese medicine of chronic heart failure and preparation method thereof.
Background technology
Chronic cardiac insufficiency is the heart systolic and diastolic function obstacle being caused by different pathogeny, develop into and make cardiac output can not meet the needs of general metabolism to blood flow in circulation volume and vasomotoricity when normal, thereby cause having the clinical syndrome that the abnormal and neurohormonal system of hemodynamic activates two aspect features.
The western medical treatment of chronic heart failure is from correcting in short time abnormal hemodynamics, progressively change into and regulate and control chronically neuro humor and even attempt to reverse myocardial abnormality and set about, though heart tonifying, diuresis, this classical heart failure conventional therapy of expansion blood vessel extensively make encouraging progress, but still there are many problems, urgently to be resolved hurrily.Giving treatment in accordance with the patient’s individuality, focuses on individual variation, improves patients ' life quality, the recurrence of prevention heart failure, and extending patient's life is treatment heart failure target.
Clinical middle application traditional Chinese medical herbal treatment heart failure has overcome limitation and the toxic and side effects of Western medicine, therefore adopt treatment by Chinese herbs advantage clearer and more definite, curative effect is convincing.
Chronic heart failure is serious global public health and a clinical problem, has very high disability rate and mortality rate.According to World Health Organization's statistics, the sickness rate of chronic heart failure in crowd is 1.5%-5.6%, and over-65s reaches 6.5%, and its sickness rate doubles for every ten years, and this may improve relevant with aged tendency of population and medical condition.Nearest " Chinese heart failure Epidemiological study " show, approximately has 4,000,000 patients with heart failure and women's prevalence higher than male at present in 35-74 year adult.Though heart failure pathogenesis has more discussion, understanding is basically identical, can be summarized as deficiency in origin and excess in superficiality.The heart (sun) gas virtual loss is this, and blood stasis, water wet, phlegm-damp is mark, and gas, blood, water three are sick each other mutually, conversion mutually.Chinese herbal treatment heart failure has multipath, many targets, the little feature of side effect.
Summary of the invention
The invention reside in a kind of Chinese medicine for the treatment of chronic heart failure and preparation method thereof is provided, the present invention has short treating period, and instant effect, without the advantage of Drug resistance and toxic and side effects.
For achieving the above object, the present invention adopts following technological means:
A kind of Chinese medicine for the treatment of chronic heart failure and preparation method thereof, comprises the following steps:
A, following component is mixed: Radix Aconiti Lateralis Preparata 10-30 mass parts, Ramulus Cinnamomi 10-15 mass parts, Fructus Zanthoxyli order 10-15 mass parts, Radix Astragali 30-60 mass parts, Radix Pseudostellariae 10-15 mass parts, Poria 15-20 mass parts, Rhizoma Alismatis 15 mass parts, Stigma Maydis 15 mass parts, Semen Lepidii (Semen Descurainiae) 15 mass parts, Herba Lycopi's 15 mass parts, Fructus Polygoni Orientalis 15 mass parts, Herba Leonuri 15-30 mass parts
B, be developed into powder after said components is mixed and make capsule or be fried into medicament.
Further, component in described steps A is: Radix Aconiti Lateralis Preparata 15 mass parts, Ramulus Cinnamomi 15 mass parts, Fructus Zanthoxyli order 15 mass parts, the Radix Astragali 30 mass parts, Radix Pseudostellariae 15 mass parts, Poria 15 mass parts, Rhizoma Alismatis 15 mass parts, Stigma Maydis 15 mass parts, Semen Lepidii (Semen Descurainiae) 15 mass parts, Herba Lycopi's 15 mass parts, Fructus Polygoni Orientalis 15 mass parts, Herba Leonuri 30 mass parts.
Further, adopt the method for decoction, select the Chinese medicinal components of following mass parts, 15 grams of Radix Aconiti Lateralis Preparata, 15 grams of Ramulus Cinnamomi, 15 grams, Fructus Zanthoxyli order, 30 grams of the Radixs Astragali, 15 grams of Radix Pseudostellariaes, 15 grams, Poria, 15 grams of Rhizoma Alismatis, 15 grams of Stigma Maydis, 15 grams of Semen Lepidii (Semen Descurainiae)s, 15 grams of Herba Lycopi, 15 grams of Fructus Polygoni Orientaliss, 30 grams of Herba Leonuris, decoct as 150ml above-mentioned Chinese medicine is dense.
Medicine principle of the present invention shows:
Radix Aconiti Lateralis Preparata: pungent, sweet, hot greatly, GUIXIN, kidney, spleen channel; Effect: there is warming and recuperating the spleen and kidney, supporing yang diversion, by the effect of cold damp eliminating, antalgic.For on the decline, yin-cold excess, the anemofrigid-damp arthralgia for the treatment of Yuanyang, key medicine that water damp-edema is full.In this side, on Radix Aconiti Lateralis Preparata, help heart-yang to promote blood circulation, lower kidney-replenishing, with benefit fire, is saved the Yuanyang of scattering and disappearing.According to modern pharmacological research: Radix Aconiti Lateralis Preparata is containing alkaloid as aconitine, and methine aconitine etc., have the effects such as heart tonifying, arrhythmia, shock, enhancing immunity.
Ramulus Cinnamomi: acrid, sweet, warm, GUIXIN, lung, urinary bladder channel; Effect: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.In this side, Ramulus Cinnamomi temperature is logical supporing yang, activating QI to promote diuresis.The pungent temperature of Ramulus Cinnamomi, rouses oneself yang-energy, and regulating fluid apssage helps the sun of three warmers, the product that must use for phlegm retention water.Modern pharmacological research: Ramulus Cinnamomi effective ingredient Oleum Cinnamomi, act as blood vessel dilating, regulate blood circulation.
Fructus Zanthoxyli order: bitter in the mouth, pungent, warm in nature.Gui Jing: spleen, urinary bladder channel.Effect: inducing diuresis to remove edema, eliminating phlegm and relieving asthma.Fructus Zanthoxyli order promoting diuresis with drugs of tasteless flavour in this side and do not consume impairment of YIN liquid.
The Radix Astragali: sweet in the mouth, feeble QI temperature, gas is thin and taste is dense, can rise to fall, and the yang aspect of yang is also, nontoxic.The warp lunar, the few the moon of lunar, the hands of foot of starting with.Effect: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.According to the modern pharmacological research Radix Astragali, normal heart is had the effect of strengthening contraction, to the heart because of poisoning or tired exhaustion, cardiotonic is more showing, and shows as and can make heart contraction amplitude increase, and discharges hypervolemia
Radix Pseudostellariae: sweet in the mouth, micro-hardship, property is flat.Effect: mend strengthening spleen and lung, supplementing QI for promoting the production of body fluid.Join the Radix Astragali, the effect of tonification increases, and conventional to control overstrain weak be effect.Radix Pseudostellariae can improve immunologic function, improves cardiac function.
Poria: property slightly sweet flavor is flat, enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, the effect of mind tranquilizing and the heart calming.Can control dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, has loose bowels, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The diuretic of Poria, reaches by strong activating the spleen pulmonary function, different from the Chinese medicine of other direct diuretic.
Rhizoma Alismatis: theory of Chinese medical science thinks that it is cold in nature, has the effect of promoting diuresis to eliminate damp pathogen.Modern medicine study, Rhizoma Alismatis can reduce serum total cholesterol and triacylglycerol content, slows down atherogenesis.
Stigma Maydis: diuresis, Stigma Maydis all has diuresis to people or rabbit, can increase chloride output.
Semen Lepidii (Semen Descurainiae): acrid in the mouth, hardship, cold in nature.Effect: drink is exempted from eliminating the pathogens from the lung, inducing diuresis to remove edema.Cure mainly phlegm retention and stop amassing, fullness in the chest is stopped up stagnant, cough and asthma; The edema of the face, breast abdomen hydrops, the diseases such as dysuria.Modern pharmacological research: Semen Lepidii (Semen Descurainiae) is containing cardiac glycoside composition.Although content is seldom, need a large amount of use just to there is cardiotonic, can make the cat heart shrink and strengthen, decreased heart rate, and can make the heart of exhaustion increase output, reduce venous pressure.
Herba Lycopi, nature and flavor slightly warm in nature, bitter in the mouth, pungent; Function cures mainly blood circulation promoting and blood stasis dispelling, line water detumescence.
Toil, tepor.Enter liver, spleen channel.Function cures mainly: blood circulation promoting and blood stasis dispelling, line water detumescence.< < herbal classic > >: main extensive abdominal edema, body face extremity edema
Fructus Polygoni Orientalis, has eliminating mass and relieving fullness eliminating stagnation, clearing away heat to alleviate pain function.For mass in the abdomen abdominal distention, hepatosplenomegaly, the tuberculosis of cervical lymph nodes, quenches one's thirst, stomachache.Control flank disease long-pending, dropsy, has a stomach-ache, lack of appetite abdominal distention, and acute catarrhal conjunctivitis, skin ulcer is swollen, scrofula.Nature and flavor are salty, cold.Liver; Spleen channel.Function cures mainly: repercussive removing mass, invigorating spleen to remove dampness.Herba Polygoni Orientalis edema of the legs during pregnancy fragrance is salty, under energy softening the hard mass rushes down, and treatment abdominal distention edema.
Herba Leonuri: young stem and leaf contains the multiple nutritional components such as protein, carbohydrate; Nature and flavor are arduous cool, have invigorate blood circulation, the effect of blood stasis dispelling, the water that disappears.Nature and flavor: bitter, pungent, be slightly cold, enter the heart, liver, urinary bladder channel.Have invigorate blood circulation, the effect of blood stasis dispelling, the water that disappears.Modern pharmacological research: Herba Leonuri protection ischemic myocardium; Anticoagulant, antithrombotic forms; Improve microcirculation, diuresis.
Research thinks that chronic heart failure take the deficient and weak YANG QI of the heart and be this, and the blood vessels stasis of blood is stagnant, fluid-retention stagnating in the interior, the turbid mark that do not turn to of expectorant, belongs to deficiency in origin and excess in superficiality, the card of simulataneous insufficiency and excessive.Blood stasis due to qi deficiency, edema due to YANG-insufficiency are the main pathogenesis of chronic cardiac insufficiency.
In side, Radix Aconiti Lateralis Preparata, Ramulus Cinnamomi, Fructus Zanthoxyli order are monarch drug:
Radix Aconiti Lateralis Preparata is hot, and its property is walked and do not kept, 12 warps that can pass through, therefore the card of all YANG QI deficiency all available it, especially can tonification kidney yang.
Ramulus Cinnamomi promoting the flow of QI-blood by warming the meridian, < < book on Chinese herbal medicine is new > > again: warming middle-JIAO promoting the circulation of blood, the dry stomach of spleen invigorating, detumescence dampness removing.
Fructus Zanthoxyli order: inducing diuresis to remove edema, eliminating phlegm and relieving asthma.
The Radix Astragali, Radix Pseudostellariae are ministerial drug.
Radix Astragali tonifying Qi and lifting yang, Radix Pseudostellariae is mended strengthening spleen and lung, supplementing QI for promoting the production of body fluid.
Poria, Rhizoma Alismatis, Stigma Maydis, Semen Lepidii (Semen Descurainiae) are dispelled water by drink, Herba Lycopi, Fructus Polygoni Orientalis, Herba Leonuri activating blood and promoting diuresis.
" the five internal organs all cause heart failure, and non-only heart also ".The vital organs of the human body are closely bound up, and the functional disorder of lung, spleen, liver, kidney all can affect in the heart heart failure occurs.Among right the five internal organs, the heart matches fire, spleen pertaining to the earth, heart spleen mother child relation, therefore in the Pathologic of heart failure, the heart, dys-splenism are the key factors that causes expectorant stasis of blood pathological product.
By above-mentioned pharmacology introduction and modern pharmacological research, proved: Radix Aconiti Lateralis Preparata, Semen Lepidii (Semen Descurainiae) have the effect of class cardiotonic glycoside, can strengthen myocardial contraction, decreased heart rate; Radix Aconiti Lateralis Preparata, the Radix Astragali, the expansible blood vessel such as Radix Salviae Miltiorrhizae, alleviates cardiac afterload; The Radix Astragali, Poria, Polyporus, Semen Plantaginis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Alismatis, Stigma Maydis, Herba Leonuris etc. have diuresis, reduce the effect of cardiac preload.
Visible, medicament selection Radix Aconiti Lateralis Preparata of the present invention, Ramulus Cinnamomi, the Radix Astragali, Radix Pseudostellariae, Poria, Rhizoma Alismatis, Herba Lycopi, Herba Leonuri, Fructus Zanthoxyli order, Fructus Polygoni Orientalis, Semen Lepidii (Semen Descurainiae), Stigma Maydis, Radix Glycyrrhizae Preparata, make each efficacy of drugs produce synergism said medicine combination, thereby can effectively treat heart failure.
The specific embodiment
Below in conjunction with the specific embodiment, the present invention is further described.
The specific embodiment one:
A kind of Chinese medicine for the treatment of chronic heart failure and preparation method thereof, comprises the following steps:
A, following component is mixed: Radix Aconiti Lateralis Preparata 10 mass parts, Ramulus Cinnamomi 10 mass parts, Fructus Zanthoxyli order 10 mass parts, the Radix Astragali 30 mass parts, Radix Pseudostellariae 10 mass parts, Poria 15 mass parts, Rhizoma Alismatis 15 mass parts, Stigma Maydis 15 mass parts, Semen Lepidii (Semen Descurainiae) 15 mass parts, Herba Lycopi's 15 mass parts, Fructus Polygoni Orientalis 15 mass parts, Herba Leonuri 15 mass parts.
B, be developed into powder after said components is mixed and make capsule, take.
The specific embodiment two:
A kind of Chinese medicine for the treatment of chronic heart failure and preparation method thereof, comprises the following steps:
A, following component is mixed: Radix Aconiti Lateralis Preparata 30 mass parts, Ramulus Cinnamomi 15 mass parts, Fructus Zanthoxyli order 15 mass parts, the Radix Astragali 60 mass parts, Radix Pseudostellariae 15 mass parts, Poria 20 mass parts, Rhizoma Alismatis 15 mass parts, Stigma Maydis 15 mass parts, Semen Lepidii (Semen Descurainiae) 15 mass parts, Herba Lycopi's 15 mass parts, Fructus Polygoni Orientalis 15 mass parts, Herba Leonuri 30 mass parts.
B, be fried into medicament after said components is mixed, take.
The specific embodiment three:
A kind of Chinese medicine for the treatment of chronic heart failure and preparation method thereof, comprises the following steps:
A, the component medicament in following is evenly mixed: Radix Aconiti Lateralis Preparata 15 mass parts, Ramulus Cinnamomi 15 mass parts, Fructus Zanthoxyli order 15 mass parts, the Radix Astragali 30 mass parts, Radix Pseudostellariae 15 mass parts, Poria 15 mass parts, Rhizoma Alismatis 15 mass parts, Stigma Maydis 15 mass parts, Semen Lepidii (Semen Descurainiae) 15 mass parts, Herba Lycopi's 15 mass parts, Fructus Polygoni Orientalis 15 mass parts, Herba Leonuri 30 mass parts.
B, be fried into medicament after said components is mixed, take.
The specific embodiment four:
This Chinese medicine is made medicament, and to take effect best, for guaranteeing dose effect and will adopting following steps by curative effect:
Component medicament in following is evenly mixed: 15 grams of Radix Aconiti Lateralis Preparata, 15 grams of Ramulus Cinnamomi, 15 grams, Fructus Zanthoxyli order, 30 grams of the Radixs Astragali, 15 grams of Radix Pseudostellariaes, 15 grams, Poria, 15 grams of Rhizoma Alismatis, 15 grams of Stigma Maydis, 15 grams of Semen Lepidii (Semen Descurainiae)s, 15 grams of Herba Lycopi, 15 grams of Fructus Polygoni Orientaliss, 30 grams of Herba Leonuris, decoct as 150ml potion on the one by above-mentioned Chinese medicine is dense.
Above-mentioned Chinese medicine preparation, for above clinical observation, is further illustrated to the clinical efficacy of Chinese medicine of the present invention.
The present invention treats 260 of chronic cardiac insufficiency patients, this 260 random selecting by name, and clinical symptoms has:
One: dyspnea: be left heart failure the earliest with modal symptom, mainly due to acute or chronic pulmonary blood stasis and vital capacity, lower institute and cause.Paroxysmal nocturnal dyspnea is a kind of performance of left heart failure, and patient suppresses awake in being everlasting and sleeping soundly, have sensation of asphyxia, is forced to sit up, and cough is frequent, occurs serious dyspnea.
Two, cough and spitting of blood: be the common sympton of left heart failure, long-term chronic congestion pulmonary vein pressure raises, and causes forming side between pulmonary circulation and bronchus blood circulation and props up, and forms the blood vessel of expansion under bronchial mucosa, once this kind of blood vessel breaks, can form massive hemoptysis.Start often night, when seat or vertical position, cough alleviates, and stock white fluidity frothy sputum is feature, the accidental blood streak.
Three, nervous, poor appetite, edema: the companion who is chronic heart failure sees symptom.These are that cardiac output is not enough, organ, perfused tissue deficiency, and vena systemica pressure raises and compensatory heart rate is accelerated relevant.
Patient took medicine of the present invention after 1 week, suppressed to breathe heavily transference cure or alleviation person accounts for 80% in 260 patients, and cardiopalmus symptom is improved or alleviated 85%; After 2 weeks, suppress and breathe heavily transference cure or alleviation person accounts for 93%, cardiopalmus symptom is improved or is alleviated 95%, and nervous, poor appetite, the remarkable improvement of edema symptom account for 96%, and general activity is not limited, and taking continuously total effective rate after several weeks is 98%.
Claims (3)
1. a Chinese medicine for the treatment of chronic heart failure, it is characterized in that: each component and mass parts are as follows: Radix Aconiti Lateralis Preparata 10-30 mass parts, Ramulus Cinnamomi 10-15 mass parts, Fructus Zanthoxyli order 10-15 mass parts, Radix Astragali 30-60 mass parts, Radix Pseudostellariae 10-15 mass parts, Poria 15-20 mass parts, Rhizoma Alismatis 15 mass parts, Stigma Maydis 15 mass parts, Semen Lepidii (Semen Descurainiae) 15 mass parts, Herba Lycopi's 15 mass parts, Fructus Polygoni Orientalis 15 mass parts, Herba Leonuri 15-30 mass parts.
2. according to the Chinese medicine of the treatment chronic heart failure described in claim 1, it is characterized in that: described component and mass parts are as follows: Radix Aconiti Lateralis Preparata 15 mass parts, Ramulus Cinnamomi 15 mass parts, Fructus Zanthoxyli order 15 mass parts, the Radix Astragali 30 mass parts, Radix Pseudostellariae 15 mass parts, Poria 15 mass parts, Rhizoma Alismatis 15 mass parts, Stigma Maydis 15 mass parts, Semen Lepidii (Semen Descurainiae) 15 mass parts, Herba Lycopi's 15 mass parts, Fructus Polygoni Orientalis 15 mass parts, Herba Leonuri 30 mass parts.
3. a preparation method for the treatment of the Chinese medicine of chronic heart failure, it is characterized in that: the Chinese medicinal components of selecting following quality, 15 grams of Radix Aconiti Lateralis Preparata, 15 grams of Ramulus Cinnamomi, 15 grams, Fructus Zanthoxyli order, 30 grams of the Radixs Astragali, 15 grams of Radix Pseudostellariaes, 15 grams, Poria, 15 grams of Rhizoma Alismatis, 15 grams of Stigma Maydis, 15 grams of Semen Lepidii (Semen Descurainiae)s, 15 grams of Herba Lycopi, 15 grams of Fructus Polygoni Orientaliss, 30 grams of Herba Leonuris, decoct as 150ml above-mentioned Chinese medicine is dense.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1305844A (en) * | 2001-01-14 | 2001-08-01 | 刘红 | Medicine for treating congestive heart failure |
| CN102038844A (en) * | 2010-12-31 | 2011-05-04 | 纪承寅 | Chinese medicine composition for treating dilated cardiomyopathy |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1305844A (en) * | 2001-01-14 | 2001-08-01 | 刘红 | Medicine for treating congestive heart failure |
| CN102038844A (en) * | 2010-12-31 | 2011-05-04 | 纪承寅 | Chinese medicine composition for treating dilated cardiomyopathy |
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