CN1305844A - Medicine for treating congestive heart failure - Google Patents

Abstract

A medicine for treating congestive heart failure is prepared from 20 Chinese-medicinal materials including red ginseng, astragulus root, fragrant solomonseal rhizome, siberian solomonseal rhizome, etc. It has high total effective rate up to 93.75%.

Description

The medicine that is used for the treatment of congestive heart failure

The present invention relates to a kind of medicine, relating to a kind of specifically is the medicine that is used for the treatment of congestive heart failure of feedstock production with the Chinese herbal medicine.

Congestive heart failure or claim that chronic cardiac insufficiency is a clinical syndrome is the end stage eventually of heart disease due to the various causes of disease, and its symptom complexity has become a great problem in the cardiovascular disease.Congested mental and physical efforts break down is a kind of over loading cardiomyopathy, it also is a kind of pathological and physiological condition of core function abnormality, this moment, the myocardial reserve consumption was lost, obstacle appears in contractile function and diastolic function, make heart can not discharge capacity blood, to satisfy the metabolic needs of body tissue, cause the Arterial system blood supply insufficiency in the course of time, the Venous system blood stasis of blood is amassed (hyperemia).Along with economic development, social senilization, the sickness rate of congestive heart failure is also rising year by year.According to U.S.'s statistics, since the nineties, about 2,500,000-3,000,000 people of annual patient's sum, annual new about 400,000 people of patient diagnosed; Death toll reached 27.4 ten thousand people in 1988.Multiple disease can cause congestive heart failure; As hypertension, acute myocardial infarction, diabetes, valvular heart disease, myocarditis, hyperthyroidism, serious anemia etc.The poor prognosis that is used for the treatment of the medicine of congestive heart failure at present, its mortality rate account for existing more than 10% of patient, are 50% in 5 years; Half of the dead died from carrying out property pump failure, and second half dies from arrhythmia caused sudden death.As seen congestive heart failure seriously jeopardizes human health and life, and modern medicine thinks all that for a long time it can not thoroughly be cured, and has become the focus of cardiovascular diseases's research.

At present, be used for the treatment of the medicine of congestive heart failure, Western medicine has the cardiac tonic of Folium Digitalis Purpureae class, catecholamines, phosphodiesterase inhibitor and multiple mechanism of action.Now, its toxic and side effects is described only to use more Folium Digitalis Purpureae class and catecholamines clinically:

One, Folium Digitalis Purpureae class: classical digitalis type cardiac glycosides, though be the ancient medicine of a class, but still be cardiac tonic commonly used at present.Its advantage is: effect is lasting, does not have drug resistance, and the neuro hormone regulating action is arranged; What have is oral effective, is applicable to long-term treatment.Shortcoming is: the treatment narrow width of cardiotonic glycoside, poison easily (toxic dose only is 2 or littler with the ratio of therapeutic dose); Lack myocardium positivity relaxation effect, the severe heart failure patient be difficult to prove effective, the reflex dilatation blood vessel function a little less than.

Two, catecholamines inotropic agent mainly contains: epinephrine, norepinephrine, isoproterenol etc.Its pluses and minuses: though have powerful positive inotropic action that in various degree myocardium relaxation effect is also arranged to cardiac muscle, the selectivity of its positive inotropic action is not high; Still to heart rate, conduction self-disciplining and vascular smooth muscle have tangible effect; Strengthen myocardial oxygen consumption, reduce heart power, can not be oral, act on of short durationly, toleration is arranged, be not suitable for chronic heart failure patient's long-term treatment.(select from " cardiovascular pharmacology " P350-P351 page or leaf, oldly repair, chief editor such as Chen Weizhou, People's Health Publisher 1998)

Purpose of the present invention just is to provide a kind of enhancing myocardial contraction that has, and improves systolic and diastolic function, can effectively control heart rate, and blood vessel dilating reduces afterload and takes the medicine that is used for the treatment of congestive heart failure that has no side effect for a long time.

Solution of the present invention is based on China's medical science to the card marquis of congestive heart failure and the understanding and the Therapeutic Principle of aspects such as the cause of disease, pathogenesis thereof, achieve with reference to modern pharmacological research, from motherland's medicine treasure-house, filter out the homologous natural edible animals and plants of medicated diet, the medicine of developing according to the theory of Chinese medical science prescription that is used for the treatment of congestive heart failure.

Medicine of the present invention is to be made by the raw material of following weight percentage range:

Radix Ginseng Rubra (or Korean Ginseng, Radix Codonopsis) 2%-6%, the Radix Astragali (or Radix Panacis Quinquefolii, Cordyceps) 5%-10%, Rhizoma Polygonati Odorati (or Radix Ophiopogonis, Herba Dendrobii, Radix Adenophorae (Radix Glehniae)) 4%-8%, Rhizoma Polygonati (or Radix Ophiopogonis, Radix Adenophorae (Radix Glehniae), Fructus Ligustri Lucidi) 4%-7%, Fructus Schisandrae Chinensis (or the Radix Paeoniae Alba, Fructus Corni) 2%-4%, Cortex Mori (or Folium Eriobotryae, Fructus Perillae) 3%-7%, Semen Lepidii (Semen Descurainiae) (or Herba Ephedrae, Semen zanthoxyli, Cortex Mori) 3%-7%, Rhizoma Alismatis (or Radix Stephaniae Tetrandrae, Polyporus, Caulis Akebiae) 4%-7%, Poria (or Poria skin, Pericarpium Arecae) 3%-7%, Radix Aconiti Lateralis Preparata (or Ramulus Cinnamomi, Herba Asari, Cortex Cinnamomi, Rhizoma Zingiberis) 2%-5%, Herba Epimedii is (or parasitic, Radix Dipsaci, field dobber, Cortex Cinnamomi) 2%-7%, Radix Salviae Miltiorrhizae (or Rhizoma Curcumae, Flos Carthami, Radix Angelicae Sinensis, rhizoma sparganic) 3%-6%, Herba Leonuri (or Herba Lycopi, Semen Persicae) 4%-7%, Hirudo (or eupolyphaga, Scorpio, Scolopendra, Sanguis Draxonis, Squama Manis) 2%-4%, Rhizoma Cyperi (processed with vinegar) (or Radix Curcumae, Rhizoma Corydalis, Semen Vaccariae) 2%-6%, Radix Paeoniae Rubra (or Radix Curcumae, Rhizoma Corydalis, Radix Notoginseng) 3%-6%, Fructus Crataegi (or Semen Raphani, Massa Medicata Fermentata) 2%-5%, Fructus Aurantii Immaturus (or Fructus Aurantii, Fructus Amomi Rotundus, Semen Raphani, Fructus Citri Sarcodactylis, Fructus Toosendan) 1.5%-4%, Rhizoma Coptidis (or Flos Lonicerae, Flos Chrysanthemi, Fructus Forsythiae, Herba Houttuyniae, Cortex Phellodendri) 2%-5%, Radix Glycyrrhizae (or Mel) 1.5%-3%.

Medicine of the present invention can select following materials by weight percentage to make:

Radix Ginseng Rubra 6%, the Radix Astragali 9%, Rhizoma Polygonati Odorati 8%, Rhizoma Polygonati 5%, Fructus Schisandrae Chinensis 4%, Cortex Mori 3%, Semen Lepidii (Semen Descurainiae) 7%, Rhizoma Alismatis 4%, Poria 7%, Radix Aconiti Lateralis Preparata 3%, Herba Epimedii 7%, Radix Salviae Miltiorrhizae 5%, Herba Leonuri 7%, Hirudo 4%, Rhizoma Cyperi (processed with vinegar) 6%, Radix Paeoniae Rubra 5%, Fructus Crataegi 5%, Fructus Aurantii Immaturus 1.5%, Rhizoma Coptidis 2%, Radix Glycyrrhizae 1.5%.

Medicine of the present invention also can be made by following materials by weight percentage:

Radix Ginseng Rubra 2%, the Radix Astragali 10%, Rhizoma Polygonati Odorati 6%, Rhizoma Polygonati 7%, Fructus Schisandrae Chinensis 3%, Cortex Mori 7%, Semen Lepidii (Semen Descurainiae) 5%, Rhizoma Alismatis 6%, Poria 5%, Radix Aconiti Lateralis Preparata 5%, Herba Epimedii 6%, Radix Salviae Miltiorrhizae 6%, Herba Leonuri 5%, Hirudo 4%, Rhizoma Cyperi (processed with vinegar) 5%, Radix Paeoniae Rubra 4%, Fructus Crataegi 4%, Fructus Aurantii Immaturus 4%, Rhizoma Coptidis 4%, Radix Glycyrrhizae 2%.

Medicine of the present invention also can be made by following weight percentages:

Radix Ginseng Rubra 5%, the Radix Astragali 8%, Rhizoma Polygonati Odorati 7%, Rhizoma Polygonati 6%, Fructus Schisandrae Chinensis 2%, Cortex Mori 6%, Semen Lepidii (Semen Descurainiae) 6%, Rhizoma Alismatis 7%, Poria 6%, Radix Aconiti Lateralis Preparata 4%, Herba Epimedii 5%, Radix Salviae Miltiorrhizae 5%, Herba Leonuri 6%, Hirudo 3%, Rhizoma Cyperi (processed with vinegar) 4%, Radix Paeoniae Rubra 6%, Fructus Crataegi 3%, Fructus Aurantii Immaturus 3%, Rhizoma Coptidis 5%, Radix Glycyrrhizae 3%.

Advantage of the present invention just is the theory of Chinese medical science according to motherland, adopts sisters to big compound recipe, removes medicine centering portion medicine and still can form identical and the anti-heart failure prescriptions that curative effect is different of treatment, medicament sources is wide, replaceability is strong, has QI invigorating and activates yang, the stasis of blood of living diuretic, strengthen myocardial contraction, improve systolic and diastolic function, strengthen the heart blood discharge amount, improve lung, renal function, relieving cough and asthma, strengthen diuresis, reduce preload, effectively control heart rate, positive and negative two-way conciliation heart rate, arrhythmia, blood vessel dilating improves cardiac function, reduce afterload, and convenient drug administration, quick.Different way of administration both can be treated chronic heart failure, also can rescue the critical patient, took for a long time to have no side effect, and had no drug resistance, and conformed to the requirement of international community to Chinese medicine.This medicine proves its total effective rate 93.75%, obvious effective rate 76.25% by a large amount of clinical and zooperies.1-2 hour urine amount obviously increases decreased heart rate after the oral medicine.Symptom is controlled in 24 hours.The state of an illness is alleviated in 48 hours.In rectally 10-15 minute is onset.To some intractable heart failures, digitalism maybe can not all be obtained satisfactory effect with the patient of Folium Digitalis Purpureae and other anti-heart failure medicine.Ascites pleural fluid to hepatic and kidney function obstacle also has obvious therapeutic action.

The present invention describes in further detail below in conjunction with specific embodiment:

Embodiment 1:

Percentage by weight by following medicine is got raw material:

Radix Ginseng Rubra 6%, the Radix Astragali 9%, Rhizoma Polygonati Odorati 8%, Rhizoma Polygonati 5%, Fructus Schisandrae Chinensis 4%, Cortex Mori 3%, Semen Lepidii (Semen Descurainiae) 7%, Rhizoma Alismatis 4%, Poria 7%, Radix Aconiti Lateralis Preparata 3%, Herba Epimedii 7%, Radix Salviae Miltiorrhizae 5%, Herba Leonuri 7%, Hirudo 4%, Rhizoma Cyperi (processed with vinegar) 6%, Radix Paeoniae Rubra 5%, Fructus Crataegi 5%, Fructus Aurantii Immaturus 1.5%, Rhizoma Coptidis 2%, Radix Glycyrrhizae 1.5%.

Manufacture method can be by Pharmacopoeia of People's Republic of China (version in 2000, the pharmacy of Chinese materia medica P227-231 of appendix 1L Chemical Industry Press page or leaf, 1993.) make:

1, Radix Ginseng Rubra, Hirudo are broken into fine powder and cross 100 mesh sieves.

2, Fructus Schisandrae Chinensis, Radix Aconiti Lateralis Preparata, Fructus Aurantii Immaturus are stipulated by pharmacopeia, standby after the extraction active ingredient.

3, the medicinal residues after the 2nd processing are sneaked in all the other each medicines, make fluid extract by pharmacopeia.

4, above-mentioned fluid extract is adopted the low-temperature reduced-pressure drying.And after it was pulverized 100 mesh sieves, mix with the 1st powder.

5, adopt the cryospray seasoning that the volatilization wet goods of the 2nd extraction is sprayed onto mix homogeneously in the 4th, adorn capsule No. 0, every 0.5 gram.

Embodiment 2:

Percentage by weight by following medicine is got raw material:

Radix Ginseng Rubra 2%, the Radix Astragali 10%, Rhizoma Polygonati Odorati 6%, Rhizoma Polygonati 7%, Fructus Schisandrae Chinensis 3%, Cortex Mori 7%, Semen Lepidii (Semen Descurainiae) 5%, Rhizoma Alismatis 6%, Poria 5%, Radix Aconiti Lateralis Preparata 5%, Herba Epimedii 6%, Radix Salviae Miltiorrhizae 6%, Herba Leonuri 5%, Hirudo 4%, Rhizoma Cyperi (processed with vinegar) 5%, Radix Paeoniae Rubra 4%, Fructus Crataegi 4%, Fructus Aurantii Immaturus 4%, Rhizoma Coptidis 4%, Radix Glycyrrhizae 2%.

Manufacture method is with embodiment 1.

Embodiment 3:

Percentage by weight by following medicine is got raw material:

Radix Ginseng Rubra 5%, the Radix Astragali 8%, Rhizoma Polygonati Odorati 7%, Rhizoma Polygonati 6%, Fructus Schisandrae Chinensis 2%, Cortex Mori 6%, Semen Lepidii (Semen Descurainiae) 6%, Rhizoma Alismatis 7%, Poria 6%, Radix Aconiti Lateralis Preparata 4%, Herba Epimedii 5%, Radix Salviae Miltiorrhizae 5%, Herba Leonuri 6%, Hirudo 3%, Rhizoma Cyperi (processed with vinegar) 4%, Radix Paeoniae Rubra 6%, Fructus Crataegi 3%, Fructus Aurantii Immaturus 3%, Rhizoma Coptidis 5%, Radix Glycyrrhizae 3%.

Manufacture method is with embodiment 1.

Instructions of taking:

1, oral: three-four times on the one, each 4-6 grain.

2, during first aid, add mixing in the 150ml eliminating cold for resuscitation water with the 20-40 grain, rectum splashes into, and per minute 15-20 drips, and drips off in 30-40 minute, and at 8-12 hour every day once.

Claims (4)

1, a kind of medicine that is used for the treatment of congestive heart failure is characterized in that: it is the medicament of being made by following weight percentages:

Radix Ginseng Rubra (or Korean Ginseng, Radix Codonopsis) 2%-6%, the Radix Astragali (or Radix Panacis Quinquefolii, Cordyceps) 5%-10%, Rhizoma Polygonati Odorati (or Radix Ophiopogonis, Herba Dendrobii, Radix Adenophorae (Radix Glehniae)) 4%-8%, Rhizoma Polygonati (or Radix Ophiopogonis, Radix Adenophorae (Radix Glehniae), Fructus Ligustri Lucidi) 4%-7%, Fructus Schisandrae Chinensis (or the Radix Paeoniae Alba, Fructus Corni) 2%-4%, Cortex Mori (or Folium Eriobotryae, Fructus Perillae) 3%-7%, Semen Lepidii (Semen Descurainiae) (or Herba Ephedrae, Semen zanthoxyli, Cortex Mori) 3%-7%, Rhizoma Alismatis (or Radix Stephaniae Tetrandrae, Polyporus, Caulis Akebiae) 4%-7%, Poria (or Poria skin, Pericarpium Arecae) 3%-7%, Radix Aconiti Lateralis Preparata (or Ramulus Cinnamomi, Herba Asari, Cortex Cinnamomi, Rhizoma Zingiberis) 2%-5%, Herba Epimedii is (or parasitic, Radix Dipsaci, field dobber, Cortex Cinnamomi) 2%-7%, Radix Salviae Miltiorrhizae (or Rhizoma Curcumae, Flos Carthami, Radix Angelicae Sinensis, rhizoma sparganic) 3%-6%, Herba Leonuri (or Herba Lycopi, Semen Persicae) 4%-7%, Hirudo (or eupolyphaga, Scorpio, Scolopendra, Sanguis Draxonis, Squama Manis) 2%-4%, Rhizoma Cyperi (processed with vinegar) (or Radix Curcumae, Rhizoma Corydalis, Semen Vaccariae) 2%-6%, Radix Paeoniae Rubra (or Radix Curcumae, Rhizoma Corydalis, Radix Notoginseng) 3%-6%, Fructus Crataegi (or Semen Raphani, Massa Medicata Fermentata) 2%-5%, Fructus Aurantii Immaturus (or Fructus Aurantii, Fructus Amomi Rotundus, Semen Raphani, Fructus Citri Sarcodactylis, Fructus Toosendan) 1.5%-4%, Rhizoma Coptidis (or Flos Lonicerae, Flos Chrysanthemi, Fructus Forsythiae, Herba Houttuyniae, Cortex Phellodendri) 2%-5%, Radix Glycyrrhizae (or Mel) 1.5%-3%.

2, the medicine that is used for the treatment of congestive heart failure according to claim 1 is characterized in that: it is the medicament of being made by following weight percentages:

Radix Ginseng Rubra 6%, the Radix Astragali 9%, Rhizoma Polygonati Odorati 8%, Rhizoma Polygonati 5%, Fructus Schisandrae Chinensis 4%, Cortex Mori 3%, Semen Lepidii (Semen Descurainiae) 7%, Rhizoma Alismatis 4%, Poria 7%, Radix Aconiti Lateralis Preparata 3%, Herba Epimedii 7%, Radix Salviae Miltiorrhizae 5%, Herba Leonuri 7%, Hirudo 4%, Rhizoma Cyperi (processed with vinegar) 6%, Radix Paeoniae Rubra 5%, Fructus Crataegi 5%, Fructus Aurantii Immaturus 1.5%, Rhizoma Coptidis 2%, Radix Glycyrrhizae 1.5%.

3, the medicine that is used for the treatment of congestive heart failure according to claim 1 is characterized in that: it is the medicament of being made by following weight percentages:

Radix Ginseng Rubra 2%, the Radix Astragali 10%, Rhizoma Polygonati Odorati 6%, Rhizoma Polygonati 7%, Fructus Schisandrae Chinensis 3%, Cortex Mori 7%, Semen Lepidii (Semen Descurainiae) 5%, Rhizoma Alismatis 6%, Poria 5%, Radix Aconiti Lateralis Preparata 5%, Herba Epimedii 6%, Radix Salviae Miltiorrhizae 6%, Herba Leonuri 5%, Hirudo 4%, Rhizoma Cyperi (processed with vinegar) 5%, Radix Paeoniae Rubra 4%, Fructus Crataegi 4%, Fructus Aurantii Immaturus 4%, Rhizoma Coptidis 4%, Radix Glycyrrhizae 2%.

4, the medicine that is used for the treatment of congestive heart failure according to claim 1 is characterized in that: it is the medicament of being made by following weight percentages:

Radix Ginseng Rubra 5%, the Radix Astragali 8%, Rhizoma Polygonati Odorati 7%, Rhizoma Polygonati 6%, Fructus Schisandrae Chinensis 2%, Cortex Mori 6%, Semen Lepidii (Semen Descurainiae) 6%, Rhizoma Alismatis 7%, Poria 6%, Radix Aconiti Lateralis Preparata 4%, Herba Epimedii 5%, Radix Salviae Miltiorrhizae 5%, Herba Leonuri 6%, Hirudo 3%, Rhizoma Cyperi (processed with vinegar) 4%, Radix Paeoniae Rubra 6%, Fructus Crataegi 3%, Fructus Aurantii Immaturus 3%, Rhizoma Coptidis 5%, Radix Glycyrrhizae 3%.