CN104922543A - Medicine composite for treating amenorrhea and preparation method thereof - Google Patents
Medicine composite for treating amenorrhea and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine composite for treating amenorrhea and a preparation method thereof and belongs to the technical field of traditional Chinese medicine. The medicine composite is prepared with folium artemisiae argyi, manis pentadactyla, carp scales, angelica sinensis, ginseng, ligusticum wallichii, radix paeoniae alba, costustoot, cinnamon, eucommia ulmoides, semen cuscutae, walnut kernels, seeds of job's tears, pericarpium citri reticulatae and liquorice. The medicine composite is effective in tonifying the Qi, invigorating the blood circulation, regulating the menstruation, relieving pains, dispelling the cold, removing the blood stasis, tonifying the liver and the kidney, strengthening the spleen and tonifying the lung, and the medicine composite has the advantages of being simple in preparation process, good in effect, low in side effect, convenient to take, easy to apply and popularize and the like.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate to a kind of pharmaceutical composition for the treatment of amenorrhea and preparation method thereof.
Background technology
Amenorrhea is symptom common in gynaecopathia, can be caused by various different reason.Usually amenorrhea is divided into constitutional and Secondary cases two kinds.All persons that do not pass through yet over 18 years old are called primary amenorrhea; After menarche, in any time before normal menopause (gestation or age of sucking except), menstruation apolipsis is called secondary amenorrhea more than 6 months persons.Menstruation causes endometrical cycle to come off by the periodic adjustment of hypothalamic-pituitary-ovarian axis to be formed, therefore any organic or functional change occurred on the links in hypothalamus, hypophysis, ovary and reproductive tract particularly uterus, all may cause amenorrhea.Organic and the functional exception of other endocrine gland, also may affect menstruation so that amenorrhea occurs.
In recent years, along with the increase of life stress, just there is the phenomenon of amenorrhea too early in a lot of women before menopause.Amenorrhea is very large on the impact of women's physical and mental health.Amenorrhea is a kind of gynecological common disease, clinical manifestation: from ischomenia, association's abdominal distention and pain symptom is the most outstanding, the traditional Chinese medical science is thought: the generation of amenorrhea, void is had to have reality, many with empty person, reality person is few, void person is due to congenital defect or the fecund exhaustion due to sexual indulgence day after tomorrow, prolonged illness serious disease, improper diet and overtiredness, the factor such as to worry too much of being worried causes kidney qi weakness, or deficient qi and blood, or deficiency of YIN blood is dry, depletion of blood can under, and cause amenorrhea due to blood depletion, reality person is due to internal injury caused by excess of seven emotions or experience cold and heat damp or ferritic obesity, excessive phlegm wets more, cause qi depression to blood stasis, or stagnation of phlegm-damp, blockage of vessel, menses must not be descending and cause blood every amenorrhea.According to theory of Chinese medical science, for the pathogeny of amenorrhea, with depressed liver-energy dispersing and QI regulating, benefiting vital QI and blood, dispelling cold by warming the meridian, blood circulation promoting and blood stasis dispelling for the rule for the treatment of, carry out dialectical prescription compatibility, to reach the object for the treatment of both the principal and secondary aspects of a disease.At present, the medicine for the treatment of amenorrhea is also a lot, but there is the deficiencies such as curative effect instability, treatment time is long, side effect is large.
Chinese patent 201310308011.1 discloses a kind of Chinese medicine composition for the treatment of amenorrhea, this Chinese medicine composition is prepared from by the raw material of following weight portion: Radix Codonopsis 20-30 part, Radix Rehmanniae Preparata 20-30 part, Herba Epimedii 20-30 part, Folium Photiniae (Folium Photiniae serrulatae) 20-30 part, Radix Angelicae Sinensis 20-30 part, Radix Paeoniae Alba 20-30 part, Herba Leonuri 10-20 part, Radix Astragali 10-15 part, Cornu Cervi Degelatinatum 10-15 part, Rhizoma Atractylodis Macrocephalae 5-15 part, Poria 5-15 part, Radix Rhapontici 5-15 part, Fructus Liquidambaris 5-15 part, Fructus Leonuri 5-15 part, Rhizoma Cyperi 5-15 part, Ramulus Cinnamomi 5-15 part, Fructus Lycii 5-15 part, Fructus Ligustri Lucidi 5-15 part, Semen Cuscutae 5-15 part, Fructus Rubi 5-15 part, Herba Ephedrae 5-15 part, Cortex Mori 5-15 part, Radix Achyranthis Bidentatae 5-15 part, Flos Carthami 5-15 part, Radix Bupleuri 5-15 part, Herba Lycopi 5-15 part, Radix Curcumae 5-15 part, Radix Glycyrrhizae 5-15 part, Eupolyphaga Seu Steleophaga 3-9 part, Hirudo 3-9 part, Radix Platycodonis 3-9 part, Rhizoma Chuanxiong 3-9 part.This Chinese medicine composition has stable curative effect, treatment time is short, side effect is little effect, but effect is not very remarkable in dispersing cold for relieving pain.
Summary of the invention
The technical problem to be solved in the present invention overcomes the deficiencies in the prior art, a kind of pharmaceutical composition for the treatment of amenorrhea is provided, this pharmaceutical composition has inrigorating qi and promoting blood circulation, effect of menstruction regulating and pain relieving, cold expelling blood stasis dispelling, liver and kidney tonifying and spleen invigorating lung benefiting, also have that preparation technology is simple, good effect, side effect be low, taking convenience and be easy to advantages such as applying, in addition, the present invention also provides corresponding manufacturing process to be made and facilitate easy-to-use preparation under the prerequisite ensureing curative effect by this pharmaceutical composition.
Pharmaceutical composition of the present invention is prepared from by the raw material of following parts by weight:
Folium Artemisiae Argyi 5-30 part, Squama Manis 5-10 part, Squama Cyprinus carpio 3-10 part, Radix Angelicae Sinensis 6-12 part, Radix Ginseng 3-10 part, Rhizoma Chuanxiong 3-10 part, Radix Paeoniae Alba 6-15 part, Radix Aucklandiae 1-10 part, Cortex Cinnamomi 1-5 part, Cortex Eucommiae 6-12 part, Semen Cuscutae 6-12 part, semen juglandis 9-15 part, Semen Coicis 3-10 part, Pericarpium Citri Reticulatae 3-10 part and Radix Glycyrrhizae 1-10 part.
Preferably, described pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Artemisiae Argyi 5 parts, Squama Manis 5 parts, Squama Cyprinus carpio 3 parts, Radix Angelicae Sinensis 6 parts, Radix Ginseng 3 parts, Rhizoma Chuanxiong 3 parts, the Radix Paeoniae Alba 6 parts, the Radix Aucklandiae 1 part, Cortex Cinnamomi 1 part, the Cortex Eucommiae 6 parts, Semen Cuscutae 6 parts, semen juglandis 9 parts, Semen Coicis 3 parts, Pericarpium Citri Reticulatae 3 parts and 1 part, Radix Glycyrrhizae.
Preferably, described pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Artemisiae Argyi 30 parts, Squama Manis 10 parts, Squama Cyprinus carpio 10 parts, Radix Angelicae Sinensis 12 parts, Radix Ginseng 10 parts, Rhizoma Chuanxiong 10 parts, the Radix Paeoniae Alba 15 parts, the Radix Aucklandiae 10 parts, Cortex Cinnamomi 5 parts, the Cortex Eucommiae 12 parts, Semen Cuscutae 12 parts, semen juglandis 15 parts, Semen Coicis 10 parts, Pericarpium Citri Reticulatae 10 parts and 10 parts, Radix Glycyrrhizae.
Preferably, described pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Artemisiae Argyi 20 parts, Squama Manis 8 parts, Squama Cyprinus carpio 8 parts, Radix Angelicae Sinensis 9 parts, Radix Ginseng 7 parts, Rhizoma Chuanxiong 7 parts, the Radix Paeoniae Alba 12 parts, the Radix Aucklandiae 5 parts, Cortex Cinnamomi 3 parts, the Cortex Eucommiae 9 parts, Semen Cuscutae 9 parts, semen juglandis 13 parts, Semen Coicis 7 parts, Pericarpium Citri Reticulatae 8 parts and 8 parts, Radix Glycyrrhizae.
Described pharmaceutical composition is made into capsule, granule, tablet or pill.
Accordingly, the preparation method of described pharmaceutical composition comprises following step:
Step one: prepare Folium Artemisiae Argyi extract: take Folium Artemisiae Argyi, adds the vinegar of Folium Artemisiae Argyi weight 10-30%, fry 30-40min at 150-250 DEG C after, drying and crushing, obtain crushed material, add the alcoholic solution of mass concentration 30-60% in crushed material, the solid-liquid ratio of described crushed material and alcoholic solution is 1g:10-50mL, under reflux conditions extract 2-6h, filter, obtain filtrate, concentrated filtrate, drying, obtains Folium Artemisiae Argyi extract;
Step 2: take Squama Manis, Squama Cyprinus carpio, Radix Angelicae Sinensis, Radix Ginseng, Rhizoma Chuanxiong, the Radix Paeoniae Alba, the Radix Aucklandiae, Cortex Cinnamomi, the Cortex Eucommiae, Semen Cuscutae, semen juglandis, Semen Coicis, Pericarpium Citri Reticulatae and Radix Glycyrrhizae, above-mentioned Chinese medicine powder is broken into coarse powder, the alcoholic solution that volumetric concentration is 40%-90% is doubly added according to the 3-8 of coarse powder gross weight, reflux, extract, three times, return time is 1-3h, filter, obtain filtrate, ethanol is reclaimed in distilling under reduced pressure, be evaporated to the extractum of relative density 1.25-1.35, dry, be ground into powder, mix with the Folium Artemisiae Argyi extract that step one obtains, stir, obtain pharmaceutical composition of the present invention.
Source, the nature and flavor of the present invention's component used, return through and effect:
Folium Artemisiae Argyi: be the dried leaves of feverfew Chinese mugwort; Its nature and flavor acrid, bitter, warm, returns liver,spleen,kidney warp; Folium Artemisiae Argyi has the effects such as warming the meridian for stopping bleeding, dispersing cold for relieving pain, regulating menstruation are antiabortive, removing damp to relieve itching, dredge the meridian passage.
Squama Manis: this product is the scute of Manidae animal Squama Manis; Salty in the mouth, cold nature; Return liver, stomach warp; To stimulate the menstrual flow stimulating milk secretion, detumescence and apocenosis, expel wind to dredge collateral.
Squama Cyprinus carpio: this product is the scale of Cyprinidae animal Cyprinus carpio; Sweet in the mouth, salty, cold in nature; Return, spleen, lung meridian; Loose blood, hemostasis.
Radix Angelicae Sinensis: this product is the dry root of umbelliferae angelica; Sweet in the mouth, pungent, warm in nature; Return liver, the heart, spleen channel; Inrigorating qi and promoting blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Radix Ginseng: this product is the dry root of Araliaceae Radix Ginseng; Sweet in the mouth, the micro-hardship of property, flat; Return spleen, lung, heart channel; Strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid, and calms the nerves.
Rhizoma Chuanxiong: this product is the dry rhizome of samphire Rhizoma Chuanxiong; Acrid in the mouth, warm in nature; Return liver, gallbladder, pericardium channel; Blood-activating and qi-promoting, wind-expelling pain-stopping.
The Radix Paeoniae Alba: this product is the dry root of ranunculaceae plant Radix Paeoniae; Bitter in the mouth, acid, cold nature; Return liver, spleen channel; Suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation.
The Radix Aucklandiae: this product is the dry root of the feverfew Radix Aucklandiae; Acrid in the mouth, hardship, warm in nature; Return spleen, stomach, large intestine, three burnt, gallbladder meridians; Promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.
Cortex Cinnamomi: this product is the dry bark of canella Cortex Cinnamomi; Acrid in the mouth, sweet, extremely hot in nature; Return kidney, spleen, the heart, Liver Channel; Mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.
The Cortex Eucommiae: this product is the dry bark of the Eucommiaceae plant Cortex Eucommiae; Sweet in the mouth, warm in nature; Return liver, kidney channel; Invigorating the liver and kidney, bone and muscle strengthening, antiabortive.
Semen Cuscutae: this product is the dry mature seed of convolvulus cuscuta plant; Sweet in the mouth, warm in nature; Return liver,kidney,spleen warp; Nourishing the liver and kidney, controlling nocturnal emission with astringent drugs reducing urination, antiabortive, improving eyesight, antidiarrheal.
Semen juglandis: this product is the kernel of juglandaceae plant Semen Juglandis; Sweet in the mouth, warm in nature; Enter kidney, lung meridian; Benefiting qi and nourishing blood, tonifying the kidney to consolidate the essence, warming the lung Dingchuan.
Semen Coicis: this product is the kernel of grass Semen Coicis; Slightly sweet flavor is cold nature, nontoxic; Enter spleen, stomach, lung, large intestine channel; Clearing away heat-damp and promoting diuresis, except rheumatism, diuresis, lung benefiting evacuation of pus, strengthening the spleen and stomach, bone and muscle strengthening.
Pericarpium Citri Reticulatae: be the dry mature skin of rutaceae orange and variety thereof; Bitter in the mouth, pungent, warm in nature; Return lung, spleen channel; Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Sweet in the mouth, property is put down; GUIXIN, lung, spleen, stomach warp; Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
Compared with prior art, the present invention has following technical advantage:
1, pharmaceutical composition of the present invention is compared with the medicine of other treatment amenorrhea, and at inrigorating qi and promoting blood circulation, the aspects such as menstruction regulating and pain relieving, cold expelling blood stasis dispelling, liver and kidney tonifying and spleen invigorating lung benefiting have more remarkable efficacy.
2, compared with the chemotherapeutic agent of Current therapeutic amenorrhea, pharmaceutical composition of the present invention is natural pure Chinese medicinal preparation, untoward reaction and side effect significantly reduce, and pharmaceutical composition effect of the present invention is comprehensive, medication effect is better, efficiently solve the morbidity root of amenorrhea, and improve the quality of life of patient.
3, pharmaceutical composition of the present invention also has that compatibility science, preparation technology are simple, good effect, side effect are low, taking convenience and be easy to advantages such as applying.
Detailed description of the invention
It will be understood by those skilled in the art that technology disclosed in following examples represents the technology playing good action in the practice of the invention of the present inventor's discovery.But, many changes can be made in disclosed specific embodiments, and still obtain same or analogous result, and not depart from the spirit and scope of the present invention.
embodiment 1:
The embodiment of the present invention 1 pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Artemisiae Argyi 5 parts, Squama Manis 5 parts, Squama Cyprinus carpio 3 parts, Radix Angelicae Sinensis 6 parts, Radix Ginseng 3 parts, Rhizoma Chuanxiong 3 parts, the Radix Paeoniae Alba 6 parts, the Radix Aucklandiae 1 part, Cortex Cinnamomi 1 part, the Cortex Eucommiae 6 parts, Semen Cuscutae 6 parts, semen juglandis 9 parts, Semen Coicis 3 parts, Pericarpium Citri Reticulatae 3 parts and 1 part, Radix Glycyrrhizae.
Preparation method is as follows:
Step one: prepare Folium Artemisiae Argyi extract: take Folium Artemisiae Argyi, adds the vinegar of Folium Artemisiae Argyi weight 10%, fry 30min at 150 DEG C after, drying and crushing, obtain crushed material, add the alcoholic solution of mass concentration 30% in crushed material, the solid-liquid ratio of described crushed material and alcoholic solution is 1g:15mL, under reflux conditions extract 3h, filter, obtain filtrate, concentrated filtrate, drying, obtains Folium Artemisiae Argyi extract;
Step 2: take Squama Manis, Squama Cyprinus carpio, Radix Angelicae Sinensis, Radix Ginseng, Rhizoma Chuanxiong, the Radix Paeoniae Alba, the Radix Aucklandiae, Cortex Cinnamomi, the Cortex Eucommiae, Semen Cuscutae, semen juglandis, Semen Coicis, Pericarpium Citri Reticulatae and Radix Glycyrrhizae, above-mentioned Chinese medicine powder is broken into coarse powder, the alcoholic solution that volumetric concentration is 60% is added according to 6 times of coarse powder gross weight, reflux, extract, three times, return time is 2h, filter, obtain filtrate, ethanol is reclaimed in distilling under reduced pressure, be evaporated to the extractum of relative density 1.30, dry, be ground into powder, mix with the Folium Artemisiae Argyi extract that step one obtains, stir, obtain the embodiment of the present invention 1 pharmaceutical composition.Add the adjuvant for the preparation of capsule preparations, incapsulate in shell, obtain the capsule of the embodiment of the present invention 1 pharmaceutical composition.
embodiment 2:
The embodiment of the present invention 2 pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Artemisiae Argyi 30 parts, Squama Manis 10 parts, Squama Cyprinus carpio 10 parts, Radix Angelicae Sinensis 12 parts, Radix Ginseng 10 parts, Rhizoma Chuanxiong 10 parts, the Radix Paeoniae Alba 15 parts, the Radix Aucklandiae 10 parts, Cortex Cinnamomi 5 parts, the Cortex Eucommiae 12 parts, Semen Cuscutae 12 parts, semen juglandis 15 parts, Semen Coicis 10 parts, Pericarpium Citri Reticulatae 10 parts and 10 parts, Radix Glycyrrhizae.
Preparation method is as follows:
Step one: prepare Folium Artemisiae Argyi extract: take Folium Artemisiae Argyi, adds the vinegar of Folium Artemisiae Argyi weight 10%, fry 30min at 150 DEG C after, drying and crushing, obtain crushed material, add the alcoholic solution of mass concentration 30% in crushed material, the solid-liquid ratio of described crushed material and alcoholic solution is 1g:15mL, under reflux conditions extract 3h, filter, obtain filtrate, concentrated filtrate, drying, obtains Folium Artemisiae Argyi extract;
Step 2: take Squama Manis, Squama Cyprinus carpio, Radix Angelicae Sinensis, Radix Ginseng, Rhizoma Chuanxiong, the Radix Paeoniae Alba, the Radix Aucklandiae, Cortex Cinnamomi, the Cortex Eucommiae, Semen Cuscutae, semen juglandis, Semen Coicis, Pericarpium Citri Reticulatae and Radix Glycyrrhizae, above-mentioned Chinese medicine powder is broken into coarse powder, the alcoholic solution that volumetric concentration is 60% is added according to 6 times of coarse powder gross weight, reflux, extract, three times, return time is 2h, filter, obtain filtrate, ethanol is reclaimed in distilling under reduced pressure, be evaporated to the extractum of relative density 1.30, dry, be ground into powder, mix with the Folium Artemisiae Argyi extract that step one obtains, stir, obtain the embodiment of the present invention 2 pharmaceutical composition.Add the adjuvant for the preparation of capsule preparations, incapsulate in shell, obtain the capsule of the embodiment of the present invention 2 pharmaceutical composition.
embodiment 3:
The embodiment of the present invention 3 pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Artemisiae Argyi 20 parts, Squama Manis 8 parts, Squama Cyprinus carpio 8 parts, Radix Angelicae Sinensis 9 parts, Radix Ginseng 7 parts, Rhizoma Chuanxiong 7 parts, the Radix Paeoniae Alba 12 parts, the Radix Aucklandiae 5 parts, Cortex Cinnamomi 3 parts, the Cortex Eucommiae 9 parts, Semen Cuscutae 9 parts, semen juglandis 13 parts, Semen Coicis 7 parts, Pericarpium Citri Reticulatae 8 parts and 8 parts, Radix Glycyrrhizae.
Preparation method is as follows:
Step one: prepare Folium Artemisiae Argyi extract: take Folium Artemisiae Argyi, adds the vinegar of Folium Artemisiae Argyi weight 10%, fry 30min at 150 DEG C after, drying and crushing, obtain crushed material, add the alcoholic solution of mass concentration 30% in crushed material, the solid-liquid ratio of described crushed material and alcoholic solution is 1g:15mL, under reflux conditions extract 3h, filter, obtain filtrate, concentrated filtrate, drying, obtains Folium Artemisiae Argyi extract;
Step 2: take Squama Manis, Squama Cyprinus carpio, Radix Angelicae Sinensis, Radix Ginseng, Rhizoma Chuanxiong, the Radix Paeoniae Alba, the Radix Aucklandiae, Cortex Cinnamomi, the Cortex Eucommiae, Semen Cuscutae, semen juglandis, Semen Coicis, Pericarpium Citri Reticulatae and Radix Glycyrrhizae, above-mentioned Chinese medicine powder is broken into coarse powder, the alcoholic solution that volumetric concentration is 60% is added according to 6 times of coarse powder gross weight, reflux, extract, three times, return time is 2h, filter, obtain filtrate, ethanol is reclaimed in distilling under reduced pressure, be evaporated to the extractum of relative density 1.30, dry, be ground into powder, mix with the Folium Artemisiae Argyi extract that step one obtains, stir, obtain the embodiment of the present invention 3 pharmaceutical composition.Add the adjuvant for the preparation of capsule preparations, incapsulate in shell, obtain the capsule of the embodiment of the present invention 3 pharmaceutical composition.
embodiment 4:
The embodiment of the present invention 4 pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Artemisiae Argyi 5 parts, Squama Manis 5 parts, Squama Cyprinus carpio 3 parts, Radix Angelicae Sinensis 6 parts, Radix Ginseng 3 parts, Rhizoma Chuanxiong 3 parts, the Radix Paeoniae Alba 6 parts, the Radix Aucklandiae 1 part, Cortex Cinnamomi 1 part, the Cortex Eucommiae 6 parts, Semen Cuscutae 6 parts, semen juglandis 9 parts, Semen Coicis 3 parts, Pericarpium Citri Reticulatae 3 parts and 1 part, Radix Glycyrrhizae.
Preparation method is as follows:
Take Folium Artemisiae Argyi, Squama Manis, Squama Cyprinus carpio, Radix Angelicae Sinensis, Radix Ginseng, Rhizoma Chuanxiong, the Radix Paeoniae Alba, the Radix Aucklandiae, Cortex Cinnamomi, the Cortex Eucommiae, Semen Cuscutae, semen juglandis, Semen Coicis, Pericarpium Citri Reticulatae and Radix Glycyrrhizae, above-mentioned Chinese medicine powder is broken into coarse powder, the alcoholic solution that volumetric concentration is 60% is added according to 6 times of coarse powder gross weight, reflux, extract, three times, return time is 2h, filter, obtain filtrate, ethanol is reclaimed in distilling under reduced pressure, be evaporated to the extractum of relative density 1.30, dry, be ground into powder, mix with the Folium Artemisiae Argyi extract that step one obtains, stir, obtain the embodiment of the present invention 4 pharmaceutical composition.Add the adjuvant for the preparation of capsule preparations, incapsulate in shell, obtain the capsule of the embodiment of the present invention 4 pharmaceutical composition.
embodiment 5:
The embodiment of the present invention 5 pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Artemisiae Argyi 20 parts, Squama Manis 8 parts, Squama Cyprinus carpio 8 parts, Radix Angelicae Sinensis 9 parts, Radix Ginseng 7 parts, Rhizoma Chuanxiong 7 parts, the Radix Paeoniae Alba 12 parts, the Radix Aucklandiae 5 parts, Cortex Cinnamomi 3 parts, the Cortex Eucommiae 9 parts, Semen Cuscutae 9 parts, semen juglandis 13 parts, Semen Coicis 7 parts, Pericarpium Citri Reticulatae 8 parts and 8 parts, Radix Glycyrrhizae.
Preparation method is as follows:
Take Folium Artemisiae Argyi, Squama Manis, Squama Cyprinus carpio, Radix Angelicae Sinensis, Radix Ginseng, Rhizoma Chuanxiong, the Radix Paeoniae Alba, the Radix Aucklandiae, Cortex Cinnamomi, the Cortex Eucommiae, Semen Cuscutae, semen juglandis, Semen Coicis, Pericarpium Citri Reticulatae and Radix Glycyrrhizae, above-mentioned Chinese medicine powder is broken into coarse powder, the alcoholic solution that volumetric concentration is 60% is added according to 6 times of coarse powder gross weight, reflux, extract, three times, return time is 2h, filter, obtain filtrate, ethanol is reclaimed in distilling under reduced pressure, be evaporated to the extractum of relative density 1.30, dry, be ground into powder, mix with the Folium Artemisiae Argyi extract that step one obtains, stir, obtain the embodiment of the present invention 5 pharmaceutical composition.Add the adjuvant for the preparation of capsule preparations, incapsulate in shell, obtain the capsule of the embodiment of the present invention 5 pharmaceutical composition.
embodiment 6
The embodiment of the present invention 6 pharmaceutical composition is prepared from by the raw material of following parts by weight: Folium Artemisiae Argyi 30 parts, Squama Manis 10 parts, Squama Cyprinus carpio 10 parts, Radix Angelicae Sinensis 12 parts, Radix Ginseng 10 parts, Rhizoma Chuanxiong 10 parts, the Radix Paeoniae Alba 15 parts, the Radix Aucklandiae 10 parts, Cortex Cinnamomi 5 parts, the Cortex Eucommiae 12 parts, Semen Cuscutae 12 parts, semen juglandis 15 parts, Semen Coicis 10 parts, Pericarpium Citri Reticulatae 10 parts and 10 parts, Radix Glycyrrhizae.
Preparation method is as follows:
Take Folium Artemisiae Argyi, Squama Manis, Squama Cyprinus carpio, Radix Angelicae Sinensis, Radix Ginseng, Rhizoma Chuanxiong, the Radix Paeoniae Alba, the Radix Aucklandiae, Cortex Cinnamomi, the Cortex Eucommiae, Semen Cuscutae, semen juglandis, Semen Coicis, Pericarpium Citri Reticulatae and Radix Glycyrrhizae, above-mentioned Chinese medicine powder is broken into coarse powder, the alcoholic solution that volumetric concentration is 60% is added according to 6 times of coarse powder gross weight, reflux, extract, three times, return time is 2h, filter, obtain filtrate, ethanol is reclaimed in distilling under reduced pressure, be evaporated to the extractum of relative density 1.30, dry, be ground into powder, mix with the Folium Artemisiae Argyi extract that step one obtains, stir, obtain the embodiment of the present invention 6 pharmaceutical composition.Add the adjuvant for the preparation of capsule preparations, incapsulate in shell, obtain the capsule of the embodiment of the present invention 6 pharmaceutical composition.
pharmaceutical composition of the present invention is to the improvement result of rat blood stasis models
1, test method: get 60 healthy SD rats, body weight 0.18kg-0.2kg, male and female half and half, are divided into 6 groups at random by body weight, often organize 10, be respectively: Normal group, model group, nutagrass flatsedge rhizome bolus by seven processes group, low dose group, middle dosage group and high dose group, gastric infusion respectively, successive administration 14 days, Normal group and model group gastric infusion 0.5%CMC, all the other pharmaceutical compositions preparing to the corresponding embodiment of the present invention 3, dosage is as shown in table 1.Administration the 13rd day, 14 days, except Normal group, all the other treated animals press 1mg/Kg subcutaneous injection adrenalin hydrochloride, 2 times/day, interval 4h, and after first time injection, animal is put into 15min in 4 DEG C of frozen water by 2h.Administration is got 4-5ml blood anticoagulant heparin on the 15th day and is measured blood rheology parameter, gets liver and to weigh conversion organ coefficient.
2, result of the test: as shown in table 1, table 2
Table 1 is on the impact of rat blood stasis models liver coefficient
Note: compare with Normal group,
▲ ▲ p < 0.01; Compared with model group
★p < 0.05,
★ ★p < 0.01.
The result statistics display of liver coefficient, model group compares with normal control, and liver coefficient significantly increases.And compare with model group, pharmaceutical composition of the present invention each dosage group basic, normal, high significantly reduce liver coefficient (
p<0.01), nutagrass flatsedge rhizome bolus by seven processes group compared with model group, can reduce significantly liver coefficient (
p<0.05), but effect not as good as pharmaceutical composition of the present invention.
Table 2 is on the impact of rat blood stasis models lectin from hemolymph
Note: compare with Normal group,
▲ p < 0.05,
▲ ▲ p < 0.01; Compared with model group
★p < 0.05,
★ ★p < 0.01.
As shown in Table 2, model group compares with normal control, the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity all have and significantly increase (
p<0.05).Compare with model group, pharmaceutical composition of the present invention each dosage group basic, normal, high all significantly or pole significantly reduce the low cut index of whole blood, erythrocyte aggregation index, Casson viscosity and plasma viscosity, reduction amplitude amount effect relationship, wherein high dose group there were significant differences (
p<0.05).Under same experiment condition, nutagrass flatsedge rhizome bolus by seven processes group also reduces whole blood height cut index, the low cut index of whole blood, erythrocyte aggregation index, but its to the improvement effect of hemorheology index all not as good as pharmaceutical composition of the present invention.
Visible, pharmaceutical composition of the present invention in blood stasis removing with more excellent compared with existing medicine in reduction liver coefficient.Because amenorrhea is often because blockage of vessel, menses must not be descending and cause blood every amenorrhea, is therefore one of primary treatment principle according to theory of Chinese medical science blood circulation promoting and blood stasis dispelling.This experiment is by research pharmaceutical composition of the present invention to the improvement result of rat blood stasis models, and the symptom of blood stasis after simulating women's amenorrhea, draws its effect in blood stasis dispelling.Found by research, pharmaceutical composition of the present invention has good therapeutical effect for the blood stasis situation of rat, visible, and pharmaceutical composition of the present invention has significant effect in treatment women amenorrhea.
clinical observation on the therapeutic effect
1, case selection: in 180 routine women's amenorrhea clinical volunteers patients, age bracket is 18-45 year, and all patients all has typical amenorrhea symptom.
2, diagnosis basis:
(1) over 18 one full year of life woman, menstruation is menophania person not yet, belongs to primary amenorrhea;
(2) woman has passed through and has interrupted more than 3 months persons, belongs to secondary amenorrhea;
(3) must differentiate mutually with physiological menolipsis such as trimester of pregnancy, age of sucking, menopause.
3, efficacy assessment standard:
(1) fully recover: menstrual onset, continuous more than 3 times menorrheas;
(2) effective: menstruation recovery is risen, but menstrual cycle is abnormal;
(3) invalid; Menstruation is risen not yet.
4, instructions of taking: 180 patients are divided into 3 groups, often organize 60 people, is respectively treatment A group, treatment B group and treatment C group, take the capsule preparations (0.25g*60 grain/bottle) that the embodiment of the present invention 1,3,5 prepares respectively, every day 3 times, each 43 months is a course for the treatment of.
5, points for attention: period in a medicine is avoided and eaten raw food, greasy, fish raw meat and maror, can stop using after pregnancy.In addition, due to conditions of patients weight and course of disease length difference, also there is individual variation to drug susceptibility, patient can according to the situation drug administration of oneself.
6, therapeutic outcome:
Table 3 therapeutic outcome
As shown in Table 3, the cure rate of pharmaceutical composition of the present invention reaches 80.0%, total effective rate reaches 90.0%, the therapeutic effect of wherein treating B group is best, visible, the capsule preparations good effect of pharmaceutical composition of the present invention particularly prepared by the embodiment of the present invention 3, cure rate is high, can be used as the drug use for the treatment of women amenorrhea.
Claims (6)
1. treat the pharmaceutical composition of amenorrhea for one kind, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following weight portion: Folium Artemisiae Argyi 5-30 part, Squama Manis 5-10 part, Squama Cyprinus carpio 3-10 part, Radix Angelicae Sinensis 6-12 part, Radix Ginseng 3-10 part, Rhizoma Chuanxiong 3-10 part, Radix Paeoniae Alba 6-15 part, Radix Aucklandiae 1-10 part, Cortex Cinnamomi 1-5 part, Cortex Eucommiae 6-12 part, Semen Cuscutae 6-12 part, semen juglandis 9-15 part, Semen Coicis 3-10 part, Pericarpium Citri Reticulatae 3-10 part and Radix Glycyrrhizae 1-10 part.
2. the pharmaceutical composition for the treatment of amenorrhea as claimed in claim 1, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following weight portion: Folium Artemisiae Argyi 5 parts, Squama Manis 5 parts, Squama Cyprinus carpio 3 parts, Radix Angelicae Sinensis 6 parts, Radix Ginseng 3 parts, Rhizoma Chuanxiong 3 parts, the Radix Paeoniae Alba 6 parts, the Radix Aucklandiae 1 part, Cortex Cinnamomi 1 part, the Cortex Eucommiae 6 parts, Semen Cuscutae 6 parts, semen juglandis 9 parts, Semen Coicis 3 parts, Pericarpium Citri Reticulatae 3 parts and 1 part, Radix Glycyrrhizae.
3. the pharmaceutical composition for the treatment of amenorrhea as claimed in claim 1, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following weight portion: Folium Artemisiae Argyi 30 parts, Squama Manis 10 parts, Squama Cyprinus carpio 10 parts, Radix Angelicae Sinensis 12 parts, Radix Ginseng 10 parts, Rhizoma Chuanxiong 10 parts, the Radix Paeoniae Alba 15 parts, the Radix Aucklandiae 10 parts, Cortex Cinnamomi 5 parts, the Cortex Eucommiae 12 parts, Semen Cuscutae 12 parts, semen juglandis 15 parts, Semen Coicis 10 parts, Pericarpium Citri Reticulatae 10 parts and 10 parts, Radix Glycyrrhizae.
4. the pharmaceutical composition for the treatment of amenorrhea as claimed in claim 1, it is characterized in that, described pharmaceutical composition is prepared from by the raw material of following weight portion: Folium Artemisiae Argyi 20 parts, Squama Manis 8 parts, Squama Cyprinus carpio 8 parts, Radix Angelicae Sinensis 9 parts, Radix Ginseng 7 parts, Rhizoma Chuanxiong 7 parts, the Radix Paeoniae Alba 12 parts, the Radix Aucklandiae 5 parts, Cortex Cinnamomi 3 parts, the Cortex Eucommiae 9 parts, Semen Cuscutae 9 parts, semen juglandis 13 parts, Semen Coicis 7 parts, Pericarpium Citri Reticulatae 8 parts and 8 parts, Radix Glycyrrhizae.
5. the pharmaceutical composition of the treatment amenorrhea as described in any one of claim 1-4, is characterized in that, described pharmaceutical composition can make capsule, granule, tablet or pill.
6. the pharmaceutical composition of the treatment amenorrhea as described in any one of claim 1-4, is characterized in that, the preparation method of described pharmaceutical composition comprises following step:
Step one: prepare Folium Artemisiae Argyi extract: take Folium Artemisiae Argyi, adds the vinegar of Folium Artemisiae Argyi weight 10-30%, fry 30-40min at 150-250 DEG C after, drying and crushing, obtain crushed material, add the alcoholic solution of mass concentration 30-60% in crushed material, the solid-liquid ratio of described crushed material and alcoholic solution is 1g:10-50mL, under reflux conditions extract 2-6h, filter, obtain filtrate, concentrated filtrate, drying, obtains Folium Artemisiae Argyi extract;
Step 2: take Squama Manis, Squama Cyprinus carpio, Radix Angelicae Sinensis, Radix Ginseng, Rhizoma Chuanxiong, the Radix Paeoniae Alba, the Radix Aucklandiae, Cortex Cinnamomi, the Cortex Eucommiae, Semen Cuscutae, semen juglandis, Semen Coicis, Pericarpium Citri Reticulatae and Radix Glycyrrhizae, above-mentioned Chinese medicine powder is broken into coarse powder, the alcoholic solution that volumetric concentration is 40%-90% is doubly added according to the 3-8 of coarse powder gross weight, reflux, extract, three times, return time is 1-3h, filter, obtain filtrate, ethanol is reclaimed in distilling under reduced pressure, be evaporated to the extractum of relative density 1.25-1.35, dry, be ground into powder, mix with the Folium Artemisiae Argyi extract that step one obtains, stir, obtain pharmaceutical composition of the present invention.
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Cited By (6)
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| CN104984297A (en) * | 2015-07-24 | 2015-10-21 | 青岛蓝盛洋医药生物科技有限责任公司 | Application of pharmaceutical composition in preparation of drugs for treating amenorrhea |
| CN105169338A (en) * | 2015-10-10 | 2015-12-23 | 临沂草之美医药科技有限公司 | Medicine composition for treating female climacteric syndromes and preparation method thereof |
| CN105169271A (en) * | 2015-10-10 | 2015-12-23 | 临沂草之美医药科技有限公司 | Application of medicine composite in preparation of medicine for treating amenorrhea |
| CN105727229A (en) * | 2016-03-16 | 2016-07-06 | 烟台市蓝洋之草医药生物科技有限公司 | Application of pharmaceutical composition containing Chinese mugwort in preparing amenorrhea therapeutics |
| CN105727237A (en) * | 2016-03-16 | 2016-07-06 | 烟台市蓝洋之草医药生物科技有限公司 | Folium artemisiae argyi-containing pharmaceutical composition for treating amenorrhea |
| CN106109524A (en) * | 2016-08-16 | 2016-11-16 | 陶然 | A kind of Chinese medicine extraction compositions and preparation method thereof, Chinese medicine smokeless moxa roll and Chinese medicine massage oil |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104984297A (en) * | 2015-07-24 | 2015-10-21 | 青岛蓝盛洋医药生物科技有限责任公司 | Application of pharmaceutical composition in preparation of drugs for treating amenorrhea |
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| CN105727229A (en) * | 2016-03-16 | 2016-07-06 | 烟台市蓝洋之草医药生物科技有限公司 | Application of pharmaceutical composition containing Chinese mugwort in preparing amenorrhea therapeutics |
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| CN106109524A (en) * | 2016-08-16 | 2016-11-16 | 陶然 | A kind of Chinese medicine extraction compositions and preparation method thereof, Chinese medicine smokeless moxa roll and Chinese medicine massage oil |
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Application publication date: 20150923 |