CN1101199C - Chinese-medicinal capsule for treating hyperlipomia - Google Patents
Chinese-medicinal capsule for treating hyperlipomia Download PDFInfo
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- CN1101199C CN1101199C CN 00107136 CN00107136A CN1101199C CN 1101199 C CN1101199 C CN 1101199C CN 00107136 CN00107136 CN 00107136 CN 00107136 A CN00107136 A CN 00107136A CN 1101199 C CN1101199 C CN 1101199C
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- 239000003814 drug Substances 0.000 claims abstract description 21
- 201000005577 familial hyperlipidemia Diseases 0.000 claims abstract description 16
- 238000002360 preparation method Methods 0.000 claims abstract description 14
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 9
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 8
- 241000628997 Flos Species 0.000 claims abstract description 8
- 241000237903 Hirudo Species 0.000 claims abstract description 8
- 239000000843 powder Substances 0.000 claims abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 3
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- 235000019634 flavors Nutrition 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 9
- 201000010099 disease Diseases 0.000 abstract description 7
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- 229940079593 drug Drugs 0.000 abstract description 5
- 208000024172 Cardiovascular disease Diseases 0.000 abstract description 4
- 208000026106 cerebrovascular disease Diseases 0.000 abstract description 4
- 230000002526 effect on cardiovascular system Effects 0.000 abstract description 4
- 235000009917 Crataegus X brevipes Nutrition 0.000 abstract description 2
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 abstract description 2
- 235000009685 Crataegus X maligna Nutrition 0.000 abstract description 2
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 abstract description 2
- 235000009486 Crataegus bullatus Nutrition 0.000 abstract description 2
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- 230000007774 longterm Effects 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
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- 239000000284 extract Substances 0.000 abstract 4
- 239000006286 aqueous extract Substances 0.000 abstract 2
- 244000233890 Alisma plantago Species 0.000 abstract 1
- 235000017300 Alisma plantago Nutrition 0.000 abstract 1
- 241001061264 Astragalus Species 0.000 abstract 1
- 244000077995 Coix lacryma jobi Species 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
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- 235000006533 astragalus Nutrition 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
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- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
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- 229960001214 clofibrate Drugs 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
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- 230000000916 dilatatory effect Effects 0.000 description 1
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- 230000001225 therapeutic effect Effects 0.000 description 1
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Abstract
The present invention relates to a Chinese medicinal capsule for treating hyperlipomia. The present invention is prepared by that extract is extracted from astragalus roots, red sage roots and fleece-flower roots with etanol, and the extract is manufactured into etanol extract; the dregs of the three medicines, hawthorn fruits, chuanxiong rhizomes, flos sophorae immaturus, coix seeds, lotus leaves, water plantain, taxilli, herba and licorice roots are decocted with water for extraction, and the decoction is filtered and concentrated into aqueous extract; the etanol extract, the aqueous extract and the dry fine powder of notoginseng and hirudo are uniformly mixed, stoved, pulverized, filled into capsules and sterilized. The present invention has conspicuous curative effect, scientific and reasonable preparation process, short course of treatment, no toxic side effect and capability of treating both manifestations and root causes of diseases, and the total clinic effective rate reaches more than 95%; the present invention is superior to the existing similar medicines, and can be an effective medicine for preventing and treating hyperlipemia and cardiovascular/cerebrovascular diseases; the present invention is suitable for long-term administration by persons in middle and old age.
Description
The present invention relates to a kind of pharmaceutical composition for the treatment of hyperlipemia, particularly relating to a kind of is the Chinese medicinal capsule preparation that is used for the treatment of hyperlipemia that raw material is made with Chinese medicine.
Hyperlipemia is commonly encountered diseases, the frequently-occurring disease of present middle-aged and elderly people, by the cardiovascular and cerebrovascular disease due to the hyperlipemia is one of disease kind that mortality rate is the highest in the world, and sickness rate is the trend that rises year by year, harm to human health is increasing, has become one of key factor of cardiovascular and cerebrovascular disease generation.Therefore, how to prevent and treat hyperlipemia and become the problem that medical circle presses for solution.The Chinese and western drugs of this class disease of treatment is more at present, the Western medicine effect for reducing fat still can, but late result is not good, and side effect is bigger: how the Chinese medicine fat-reducing medicament controls angle from dialectical opinion is started with, but ignore the basic reason that causes lipid to raise, or do not considered to cause a series of pathological changes that cause because of lipid is too high.
The objective of the invention is to provide a kind of Chinese medicinal capsule preparation that is used for the treatment of hyperlipemia that can regulate the organism endocrine function, correct lipid metabolic disorder, blood circulation promoting at above deficiency.
It is considered herein that this disease mainly is because the body lipid metabolism disorder, and then cause lipid compositions such as cholesterolemia, triglyceride to be higher than normally, it and hypertension, diabetes, coronary heart disease, arteriosclerosis etc. substantial connection arranged.Modern medicine study thinks that accumulating, increasing of blood fat is the key factor that arteriosclerosis forms.Therefore, the control hyperlipemia also is one of important channel that prevents arteriosclerosis and cardiovascular and cerebrovascular disease.Therapeutic Principle of the present invention is " an activating the spleen kidney tonifying; the blood stasis dispelling of eliminating the phlegm ", adopt strengthening spleen, tonifying kidney, promoting blood circulation to remove obstruction in the collateral, vessel softening, dampness removing reduces phlegm, and in conjunction with promoting that lipid transforms metabolic method, developed the Chinese medicinal capsule preparation of treatment hyperlipemia, this capsule is that the component with following proportioning by weight is the medicament that raw material is made:
The Radix Astragali 15～30g Radix Polygoni Multiflori 10～20g Fructus Crataegi 15～30g Radix Notoginseng 10～15g
Radix Salviae Miltiorrhizae 15～30g Hirudo 5～10g Rhizoma Chuanxiong 10～20g Flos Sophorae Immaturus 15～30g
Semen Coicis 15～30g Folium Nelumbinis 10～20g Rhizoma Alismatis 15～30g Herba Taxilli 15～30g
Radix Glycyrrhizae 5～10g
Preparation method is, with 70% ethanol extraction, backflow ethanol is made pure extractum with the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori; Above three flavor medicinal residues and Fructus Crataegi, Rhizoma Chuanxiong, the Flos Sophorae Immaturus, Semen Coicis, Folium Nelumbinis, Rhizoma Alismatis, Herba Taxilli, Radix Glycyrrhizae decocting are extracted twice, each 1 hour, merge decocting liquid twice, filter, concentrate and make the water extracted immersing paste; With the dry fine powder mixing of above-mentioned two kinds of extractum and Radix Notoginseng, Hirudo, oven dry is pulverized again, divides encapsulatedly, sterilizes.
The present invention selects for use the Radix Astragali, Radix Polygoni Multiflori, Fructus Crataegi to be monarch, Radix Astragali replenishing QI to invigorate the spleen wherein, blood pressure lowering coronary dilating, blood fat reducing, enhancing human body immunity power, Radix Polygoni Multiflori invigorating the liver and kidney, benefiting essence-blood, has vessel softening, strengthen blood vessel elasticity, reduce the absorption of cholesterol, triglyceride reducing at enteral, play the effect that improves cerebral circulation, the hawthorn digesting eliminate indigestion, blood circulation promoting and blood stasis dispelling, activating spleen and strengthening stomach; Be aided with Radix Notoginseng, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Hirudo promoting blood circulation to remove obstruction in the collateral, regulate the flow of vital energy, Radix Notoginseng and Radix Salviae Miltiorrhizae, Fructus Crataegi are share has blood viscosity lowering, reduce TC and TG, improve the effect of blood circulation, the expectorant of Semen Coicis invigorating spleen for diuresis, the cool liver and clearing heat removing dampness of the Flos Sophorae Immaturus: assistant is eliminated the phlegm with Folium Nelumbinis, Rhizoma Alismatis, Herba Taxilli the kidney invigorating dampness removing: make with the Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, reach triglyceride reducing, cholesterol jointly, high density lipoprotein increasing, blood viscosity lowering, vessel softening, the effect of blood circulation promoting.
Further describe the present invention below in conjunction with embodiment:
According to the Chinese medicinal capsule preparation of the present invention preparation, its most preferred embodiment is that the component with following proportioning by weight is the medicament that raw material is made:
What first horse 15g Fructus Crataegi 20g Radix Notoginseng 10g Radix Salviae Miltiorrhizae 20g of Radix Astragali 20g
Hirudo 8g Rhizoma Chuanxiong 15g Flos Sophorae Immaturus 15g Semen Coicis 20g Folium Nelumbinis 15g
Rhizoma Alismatis 15g Herba Taxilli 15g Radix Glycyrrhizae 8g
The present invention is from nineteen ninety to 1994 year treatment hyperlipemia 115 examples, and does contrast with clofibrate group 50 examples.The capsule preparations that the treatment group is taken is according to prescription of the present invention, requires processing by the Xinzhou pharmaceutical factory of traditional Chinese medicine according to provisions for new drugs approval Chinese medicine production technology and quality standard, and the tentatively titled blood fat reducing reaches recovering capsule.Every day 3 times, each 4 (every contain concentrate medicine 0.4g, be equivalent to crude drug 5g): matched group is taken peace holder ' Yanming ' capsules for clearing (being produced by the BJ Pharmaceutical Co., Ltd.) every day 3 times, each 1 (every 0.5g).Two groups all with single blind method administration, is 1 course of treatment to take medicine 1 month, does the contrast observation after treat two courses of treatment.Observed result treatment group clinic control rate and total effective rate reach 58.3%, 95.7% respectively, and matched group then is respectively 46%, 76%, learn check by statistics, and group there is significant difference P＜0.05, two.Confirm that this product is better than contrasting the medicine clofibrate in curative effect aspect the treatment hyperlipemia, and can significantly improve the patient since due to the blood fat, hyperpiesia dizzy, breathe hard, symptoms such as uncomfortable in chest, cardiopalmus, numb limbs and tense tendons, thirsty frequent micturition, spiritlessness and weakness.
Confirm that through zoopery the present invention can significantly reduce the blood lipid level of hyperlipemia animal, improves blood viscosity and hemorheological property.Acute toxinology experiment confirms that also this product takes no obvious toxic and side effects for a long time, and is safe and reliable.
In sum, the present invention is evident in efficacy, and short treating period has no side effect, and can treat both principal and secondary aspect of disease, and is clinical Total effective rate reaches more than 95%, is better than present similar drugs, is expected to become to prevent and treat hyperlipidemia, heart and brain blood The good medicine of pipe illness is suitable for middle-aged and old long-term takings. Preparation technology of the present invention is scientific and reasonable, adopts Alcohol, water extraction method, it is fried to have avoided simple employing water extraction that water-fast active ingredient is difficult to, and waves Send out the deficiency that the property composition is easily lost, and take very convenient to carryly, have potential application and exploitation is worth.
Claims (3)
1, a kind of Chinese medicinal capsule preparation for the treatment of hyperlipemia is characterized in that it is that component with following proportioning by weight is the medicament that raw material is made:
The Radix Astragali 15～30g Radix Polygoni Multiflori 10～20g Fructus Crataegi 15～30g Radix Notoginseng 10～15g
Radix Salviae Miltiorrhizae 15～30g Hirudo 5～10g Rhizoma Chuanxiong 10～20g Flos Sophorae Immaturus 15～30g
Semen Coicis 15～30g Folium Nelumbinis 1-20g Rhizoma Alismatis 15～30g Herba Taxilli 15～30g
Radix Glycyrrhizae 5～10g
2, the Chinese medicinal capsule preparation of treatment hyperlipemia according to claim 1 is characterized in that it is that component with following proportioning by weight is the medicament that raw material is made:
Radix Astragali 20g Radix Polygoni Multiflori 15g Fructus Crataegi 20g Radix Notoginseng 10g Radix Salviae Miltiorrhizae 20g
Hirudo 8g Rhizoma Chuanxiong 15g Flos Sophorae Immaturus 15g Semen Coicis 20g Folium Nelumbinis 15g
Rhizoma Alismatis 15g Herba Taxilli 15g Radix Glycyrrhizae 8g
3, the Chinese medicinal capsule preparation of treatment hyperlipemia according to claim 1 is characterized in that preparation method is: with 70% ethanol extraction, backflow ethanol is made pure extractum with the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori; Above three flavor medicinal residues and Fructus Crataegi, Rhizoma Chuanxiong, the Flos Sophorae Immaturus, Semen Coicis, Folium Nelumbinis, Rhizoma Alismatis, Herba Taxilli, Radix Glycyrrhizae decocting are extracted twice, each 1 hour, merge decocting liquid twice, filter, concentrate and make the water extracted immersing paste: again with the dry fine powder mixing of above-mentioned two kinds of extractum and Radix Notoginseng, Hirudo, oven dry, pulverize, divides encapsulatedly, sterilize.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00107136 CN1101199C (en) | 2000-04-21 | 2000-04-21 | Chinese-medicinal capsule for treating hyperlipomia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00107136 CN1101199C (en) | 2000-04-21 | 2000-04-21 | Chinese-medicinal capsule for treating hyperlipomia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1280835A CN1280835A (en) | 2001-01-24 |
| CN1101199C true CN1101199C (en) | 2003-02-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00107136 Expired - Fee Related CN1101199C (en) | 2000-04-21 | 2000-04-21 | Chinese-medicinal capsule for treating hyperlipomia |
Country Status (1)
| Country | Link |
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| CN (1) | CN1101199C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100393247C (en) * | 2005-05-25 | 2008-06-11 | 邵建国 | Lipid-lowering beverage and preparation method thereof |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101485865B (en) * | 2009-02-11 | 2011-06-29 | 白云沂 | Chinese medicine fat-reducing plaster |
| CN102935152B (en) * | 2012-12-08 | 2014-08-20 | 滨州医学院烟台附属医院 | Traditional Chinese medicine composition for treating hyperlipidaemia as well as preparation method and application thereof |
| CN103007100B (en) * | 2013-01-14 | 2014-05-14 | 广东一方制药有限公司 | Composition with functions of body slimming and waistline reduction and preparation method of composition |
| CN104547625A (en) * | 2015-02-09 | 2015-04-29 | 王士国 | Preparation with effects of promoting digestion and reducing lipid and preparation method |
| CN105998919A (en) * | 2016-07-22 | 2016-10-12 | 龙燕妮 | Traditional Chinese medicine for treating hyperlipidemia |
-
2000
- 2000-04-21 CN CN 00107136 patent/CN1101199C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100393247C (en) * | 2005-05-25 | 2008-06-11 | 邵建国 | Lipid-lowering beverage and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN1280835A (en) | 2001-01-24 |
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