CN101301458B - Medicament for treating chronic cardiac failure and preparation thereof - Google Patents
Medicament for treating chronic cardiac failure and preparation thereof Download PDFInfo
- Publication number
- CN101301458B CN101301458B CN2008100552459A CN200810055245A CN101301458B CN 101301458 B CN101301458 B CN 101301458B CN 2008100552459 A CN2008100552459 A CN 2008100552459A CN 200810055245 A CN200810055245 A CN 200810055245A CN 101301458 B CN101301458 B CN 101301458B
- Authority
- CN
- China
- Prior art keywords
- medicine
- cardiac failure
- chronic cardiac
- mist
- heart failure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Abstract
A medicine for curing chronic cardiac failure is a capsule made of cassia twig, burnt white atractylodes rhizome, dried ginger, bulbus allii macrostemi and radix salviae. The medicine can cure senile chronic cardiac failure, pulmonary interstitial edema and bronchial asthma which meet the pathologic principle of 'a mist status disappearing, mist being condensed into fluid, the retained fluid attacking the heart just like ice attacking a river, and finally blood circulation being stagnated to cause blood stasis' with clinical manifestations of cough and dyspnea. The cough and dyspnea is worsened in case of movement of a patient and is intensified at night, and the patient can not lie down horizontally with thin expectoration or edema of lower extremities. The observation on 45 chronic cardiac failure patients taking the medicine shows that: the medicine has an obvious curative effect on chronic cardiac failure with a general effectiveness ratio of 88.89 percent.
Description
Technical field
The present invention relates to a kind of medicine of chronic heart failure, particularly relating to a kind of is the medicine of the chronic heart failure of crude drug preparation with Chinese medicine.The invention still further relates to the preparation method of this medicine.
Background technology
Heart failure (heart failure) is meant the clinical syndrome that is caused a kind of complexity of cardiac dysfunction by various heart diseases, be that myocardial contraction weakens and diastolic dysfunction, make the heart blood discharge amount can not satisfy the organism metabolism needs, cause organ and perfused tissue deficiency, occur simultaneously body circulation and (or) performance of pulmonary circulatory stasis, be the various cardiopathic serious stages.Along with aged tendency of population, hypertensive high incidence and low control rate, infusion therapy makes a large amount of patients of acute myocardial infarction reason such as survived again, the incidence rate of old people's heart failure raises day by day.According to statistics, the prevalence of 50～59 years old heart failure is that 1%, 80 years old person is up to 10%.In 50～89 years old crowd, every increase of age 10 years old, its prevalence raises 1 times.Because the gerontal patient accounts for 75% of heart failure sum, heart failure can be described as senile disease to a great extent.Heart failure is again the common cause that causes old people's death, and its 5 times of incidence rate of sudden death is to the general population.Old people's heart failure and non-aged people's heart failure has visibly different characteristics.How correctly handling old people's heart failure, reduce its sickness rate and case fatality rate, is a great medical problem.
Though there is not the diagnosis of heart failure on the Chinese medicine, still comprehensive to the understanding of cardiac function.Its rationale is thought, heart governing blood and vessels, and lung governing qi and " convergence of vessels in the lung " (" element is asked the passages through which vital energy circulates another matter "), two is dirty with occuping the part of the body cavity above the diaphragm housing the heart and lungs, and this has just determined the close association of H﹠L on physiology and pathology.Painstaking effort and lung qi are mutual dependence for existencies, and the operation of blood depends on the promotion of gas, and the defeated cloth of gas also needs the delivery of blood, says as " qi being the governor of blood, blood being the material foundation of QI ".
" upper-jiao resembling a sprayer " comes from " a Ling Shu Miraculous Pivot or Divine Axis battalion health meeting piece of writing ", and " part of the body cavity above the diaphragm housing the heart and lungs " is meant more than the diaphragm, comprises internal organs H﹠L and function thereof." mist " is meant the state that light clear essence of water and grain fills the air.The function of feel terribly worried on " upper-jiao resembling a sprayer " appearance, lung a surname dispersing water distribution paddy vital essence is filled the air the perfusion whole body as mist dew, with replenishing vital QI with drugs of warm nature whole body skin, muscles and bones, the logical space between skin and muscles of transferring, is the summary of cardiopulmonary physiological function.
No matter from western medicine still be Chinese medicine, from dissecting still on the function, cardiopulmonary are all closely bound up, influence each other.Complicated pulmonary's performance all usually appears in congenital or posteriority cardiovascular disease, and pulmonary disease also often influences the change of cardiac function.
Early stage left heart function depletion mainly is that venous return volume increases.Because gerontal patient's left ventricle reserve capabillity deficiency, when remodeling ventricle occurring, the left ventricle blood discharge amount reduces, more relatively body fluid rests on pulmonary and causes pulmonary venous pleonaemia, pulmonary venous pleonaemia causes the bronchial mucosa congestion and edema again, intra-alveolar edema causes ventilatory function and diffusion obstacle, symptom and coughs, out of breath such as obstructive dysfunction of pulmonary ventilation occur.The patient is through commentariess on classics of not getting better of symptom after the anti-infective therapy, and two times lungs are audible and moist rale still.These signs cause that just because of pulmonary venous pleonaemia the physiological status that just looks like Chinese medicine " upper-jiao resembling a sprayer " can not obtain conventional maintenance, and " mist " then is " water " with fixed attention, is " drink ", fluid-retention offending the chest and lung, and abnormal rising of lung-QI is the cough with asthma fullness in the chest then, can not put down for sleeping in." the mist attitude is multiple, the mist water that congeals into, diseases caused by retention of fluid is insulted the heart, attacks the river as ice, blood fortune stagnates and blood stasis " is embodied in cardiopalmus, moving then for very, and night is uncomfortable in chest etc." upper-jiao resembling a sprayer " of QI and blood physiological status reaches " mist coagulates and is water " " the diseases caused by retention of fluid icepro heart " that " qi being the governor of blood, blood being the material foundation of QI " developed into pathological state between cardiopulmonary, shows as " diseases caused by retention of fluid " " blood stasis " clinically, and reciprocal causation.
Aspect treatment, should carry out at the pathological state of " the mist attitude is multiple, the mist water that congeals into; the heart attacked by pathogenic water; attack the river, blood fortune stagnates and blood stasis " as ice " warming YANG to promote diuresis, as sunshine when empty; haze dissipates; the molten aquation of ice, and the mist attitude has of one's own, and blood stasis is from disappearing " symptomatic treatment, cardiopalmus, moving then then for very, fullness in the chest is uncomfortable in chest, night the cardio palmus shape also can Lock-out.So when the senile heart failure of treatment,, then obtain preferable effect clinically as being mechanism with " upper-jiao resembling a sprayer " more.
Summary of the invention
The purpose of this invention is to provide a kind of medicine that is used for the treatment of chronic heart failure, this medicine has the effect that warming YANG and promoting blood circulation, diuretic are relievingd asthma, and " the mist attitude is multiple; the mist water that congeals into; the heart attacked by pathogenic water, attacks the river as ice, and blood fortune stagnates and blood stasis " the pathology machine of can treating and meet causes, clinical manifestation is for coughing, breathing heavily, moving then for very, night, aggravation must not be put down for sleeping in, expectoration is thin, or with senile chronic heart failure, interstitial pulmonary edema, the bronchial asthma person of edema of pair of lower extremities.
A kind of manufacturing method for above mentioned medicine is provided, and is another goal of the invention of the present invention.
Medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:
Ramulus Cinnamomi 10～15 Rhizoma Atractylodis Macrocephalae preparatas 12～15
Rhizoma Zingiberis 8～15 Bulbus Allii Macrostemonis 8～15
Radix Salviae Miltiorrhizae 12～15 Fructus Schisandrae Chinensis 8～15
Semen Plantaginis 15～20 Herba Ephedrae (processed) 5～10
Pericarpium Citri Reticulatae 8～15 Radix Glycyrrhizae Preparatas 8～10
Herba Asari 3～5.
The medicine of above-mentioned each component can be made said dosage form on any pharmaceutics, and the preferred dosage form of the present invention is a capsule.
The concrete preparation method of above-mentioned each component being made medicine of the present invention is:
According to above-mentioned parts by weight, get Ramulus Cinnamomi, Rhizoma Atractylodis Macrocephalae preparata, Rhizoma Zingiberis, Bulbus Allii Macrostemonis, Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis, Semen Plantaginis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae Preparata mix homogeneously after, be ground into 80～100 purpose fine powders; Herba Asari, Herba Ephedrae (processed) decoct with water 3 times, and each 1～1.5 hour, merge 3 times decocting liquid, being condensed into relative density is the thick paste of 1.10～1.20 (50 ℃); Fine drug powder is added mix homogeneously in the thick paste, after 50～60 ℃ of dryings, be ground into 100～120 purpose medicated powder, in incapsulating, sterilization makes the capsule product.
In the prescription of the present invention, Herba Ephedrae (processed), Rhizoma Zingiberis, Herba Asari, Ramulus Cinnamomi, Fructus Schisandrae Chinensis have been contained the effect of classics recipe XIAOQINGLONG TANG; The Pericarpium Citri Reticulatae relieving cough and resolving phlegm; Rhizoma Atractylodis Macrocephalae preparata, Semen Plantaginis warming YANG and strengthening the spleen and diuretic; Radix Salviae Miltiorrhizae, Ramulus Cinnamomi warming YANG blood circulation and channel invigorating; The Radix Glycyrrhizae Preparata benefit motive has the heart tonifying diuresis simultaneously.All medicines gather altogether " warming YANG to promote diuresis, as sunshine when empty, haze dissipates; the molten aquation of ice, the mist attitude has of one's own, blood stasis is from disappearing " the multiple mist effect of warming YANG, applicable to pathomechanism is " the mist attitude is multiple, the mist water that congeals into, the heart attacked by pathogenic water; attack the river as ice, blood fortune stagnates and blood stasis ", and clinical manifestation is for coughing, breathing heavily, moving then for very, night, aggravation must not be put down for sleeping in, expectoration is thin, or with old heart failure, interstitial pulmonary edema, the bronchial asthma person of edema of pair of lower extremities.
For further investigating the clinical efficacy and the safety of medicine of the present invention, Shanxi Province's Changzhi City second the People's Hospital, Changzhi City senile disease institute have selected 45 routine heart failure patients that the curative effect of medicine of the present invention has been carried out clinical observation.
Clinical data:
By " chronic heart failure Boston score diagnostic criteria ", assist to diagnose in conjunction with Color Sonography, select outpatient service and inpatient's 90 examples altogether, wherein male 64 examples, women 26 examples, 48～83 years old age, average 65.5 years old.Patient is divided into observation group and matched group at random, every group 45 example, two groups of patient's sexes, age, state of an illness equilibrium, there was no significant difference.
Therapeutic Method:
Matched group oral nitroglycerin sheet 5～10mg, every day 3 times; Hydrochlorothiazide 10mg, spironolactone 10mg, every day 2 times.Oral medicine of the present invention is organized in treatment, every day 3 times, each 3～4.
10 days is 1 course of treatment, with the oral lapse rate that stops as clinical indexes.Detect blood rheology parameter, blood, urine, just routine and hepatic and renal function before and after the medication.Press NYHA cardiac functional grading method and estimate cardiac function.Finish the back relevant data is carried out statistical procedures the course of treatment, estimates two groups of patients' therapeutic effect.
Criterion of therapeutical effect:
According to New York heart association (NYHA) cardiac functional grading method (94 years the 9th edition) standard.
Produce effects: doing well,improving, cardiac functional grading improves more than 2 grades or 2 grades.
Effectively: doing well,improving, cardiac functional grading improves 1 grade.
Invalid: symptom is with before treating, and cardiac functional grading does not have improvement.
Increase the weight of: sx, cardiac functional grading reduces more than 1 grade.
Therapeutic effect:
Curative effect behind two groups of patient treatments is compared, the results are shown in Table 1.
Curative effect behind the table 1 liang group patient treatment relatively
Clinical observation result shows that medicine of the present invention has the obvious treatment effect for chronic heart failure, and total effective rate reaches 88.89%, compares significant difference with matched group.Medicine of the present invention occurs uncomfortable unusually during medication, and blood, urine before and after the medication, just reaches the no significant change of hepatic and renal function chemical examination.The clinical observation on the therapeutic effect result shows that safety of medicine of the present invention, effective is worth clinical application.
The specific embodiment
Embodiment 1
After getting Ramulus Cinnamomi 100g, Rhizoma Atractylodis Macrocephalae preparata 150g, Rhizoma Zingiberis 100g, Bulbus Allii Macrostemonis 100g, Radix Salviae Miltiorrhizae 150g, Fructus Schisandrae Chinensis 100g, Semen Plantaginis 150g, Pericarpium Citri Reticulatae 100g, Radix Glycyrrhizae Preparata 100g and choosing most impurity, screening and clean and dry, it is standby that mixed powder is broken into 80 order fine powders.
Herba Asari 30g, Herba Ephedrae (processed) 50g are joined in the 5L water and decoct, and the decocting that medicinal residues add same amount again boils 2 times, decocts 1.5 hours at every turn.Merge 3 times decocting liquid, filter, being condensed into relative density is the thick paste of 1.10 (50 ℃).
Add the said medicine fine powder in thick paste, mix homogeneously after 50 ℃ of dryings, is ground into 120 purpose medicated powder, and in incapsulating, sterilization makes the capsule product.
Embodiment 2
After getting Ramulus Cinnamomi 150g, Rhizoma Atractylodis Macrocephalae preparata 150g, Rhizoma Zingiberis 150g, Bulbus Allii Macrostemonis 100g, Radix Salviae Miltiorrhizae 150g, Fructus Schisandrae Chinensis 100g, Semen Plantaginis 200g, Pericarpium Citri Reticulatae 100g, Radix Glycyrrhizae Preparata 100g and choosing most impurity, screening and clean and dry, it is standby that mixed powder is broken into 80 order fine powders.
Herba Asari 35g, Herba Ephedrae (processed) 60g are joined in the 5L water and decoct, and the decocting that medicinal residues add same amount again boils 2 times, decocts 1 hour at every turn.Merge 3 times decocting liquid, filter, being condensed into relative density is the thick paste of 1.15 (50 ℃).
Add the said medicine fine powder in thick paste, mix homogeneously after 50 ℃ of dryings, is ground into 120 purpose medicated powder, and in incapsulating, sterilization makes the capsule product.
Embodiment 3
After getting Ramulus Cinnamomi 120g, Rhizoma Atractylodis Macrocephalae preparata 150g, Rhizoma Zingiberis 120g, Bulbus Allii Macrostemonis 120g, Radix Salviae Miltiorrhizae 150g, Fructus Schisandrae Chinensis 100g, Semen Plantaginis 200g, Pericarpium Citri Reticulatae 100g, Radix Glycyrrhizae Preparata 100g and choosing most impurity, screening and clean and dry, it is standby that mixed powder is broken into 100 order fine powders.
Herba Asari 40g, Herba Ephedrae (processed) 60g are joined in the 5L water and decoct, and the decocting that medicinal residues add same amount again boils 2 times, decocts 1 hour at every turn.Merge 3 times decocting liquid, filter, being condensed into relative density is the thick paste of 1.20 (50 ℃).
Add the said medicine fine powder in thick paste, mix homogeneously after 60 ℃ of dryings, is ground into 100 purpose medicated powder, and in incapsulating, sterilization makes the capsule product.
Embodiment 4
After getting Ramulus Cinnamomi 150g, Rhizoma Atractylodis Macrocephalae preparata 120g, Rhizoma Zingiberis 110g, Bulbus Allii Macrostemonis 110g, Radix Salviae Miltiorrhizae 150g, Fructus Schisandrae Chinensis 100g, Semen Plantaginis 150g, Pericarpium Citri Reticulatae 100g, Radix Glycyrrhizae Preparata 100g and choosing most impurity, screening and clean and dry, it is standby that mixed powder is broken into 80 order fine powders.
Herba Asari 35g, Herba Ephedrae (processed) 60g are joined in the 5L water and decoct, and the decocting that medicinal residues add same amount again boils 2 times, decocts 1.5 hours at every turn.Merge 3 times decocting liquid, filter, being condensed into relative density is the thick paste of 1.10 (50 ℃).
Add the said medicine fine powder in thick paste, mix homogeneously after 60 ℃ of dryings, is ground into 100 purpose medicated powder, and in incapsulating, sterilization makes the capsule product.
Claims (1)
1. the medicine of a chronic heart failure is to be crude drug by following parts by weight of traditional Chinese medicines:
Ramulus Cinnamomi 10～15 Rhizoma Atractylodis Macrocephalae preparatas 12～15
Rhizoma Zingiberis 8～15 Bulbus Allii Macrostemonis 8～15
Radix Salviae Miltiorrhizae 12～15 Fructus Schisandrae Chinensis 8～15
Semen Plantaginis 15～20 Herba Ephedrae (processed) 5～10
Pericarpium Citri Reticulatae 8～15 Radix Glycyrrhizae Preparatas 8～10
Herba Asari 3～5
Prepare according to following steps:
1), behind Ramulus Cinnamomi, Rhizoma Atractylodis Macrocephalae preparata, Rhizoma Zingiberis, Bulbus Allii Macrostemonis, Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis, Semen Plantaginis, Pericarpium Citri Reticulatae, Radix Glycyrrhizae Preparata mix homogeneously, is ground into 80～100 purpose fine powders according to above-mentioned parts by weight;
2) Herba Asari, Herba Ephedrae (processed) decoct with water 3 times, and each 1～1.5 hour, merge 3 times decocting liquid, be condensed into 50 ℃ of following relative densities and be 1.10～1.20 thick paste;
3) fine drug powder is added mix homogeneously in the thick paste, after 50～60 ℃ of dryings, be ground into 100～120 purpose medicated powder, in incapsulating, sterilization makes the capsule product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100552459A CN101301458B (en) | 2008-06-19 | 2008-06-19 | Medicament for treating chronic cardiac failure and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008100552459A CN101301458B (en) | 2008-06-19 | 2008-06-19 | Medicament for treating chronic cardiac failure and preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101301458A CN101301458A (en) | 2008-11-12 |
| CN101301458B true CN101301458B (en) | 2010-09-15 |
Family
ID=40111675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008100552459A Expired - Fee Related CN101301458B (en) | 2008-06-19 | 2008-06-19 | Medicament for treating chronic cardiac failure and preparation thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101301458B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104274702A (en) * | 2014-10-08 | 2015-01-14 | 姜志明 | Traditional Chinese medicine preparation for treating chronic cardiac-failure qi deficiency and blood stasis and syndrome of internal stagnation of fluid-dampness |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1305844A (en) * | 2001-01-14 | 2001-08-01 | 刘红 | Medicine for treating congestive heart failure |
| CN1334121A (en) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
| CN1403149A (en) * | 2002-10-24 | 2003-03-19 | 河北以岭医药研究院有限公司 | Medicines composition for treating chronic heart failure and its prepn |
-
2008
- 2008-06-19 CN CN2008100552459A patent/CN101301458B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1305844A (en) * | 2001-01-14 | 2001-08-01 | 刘红 | Medicine for treating congestive heart failure |
| CN1334121A (en) * | 2001-08-31 | 2002-02-06 | 石家庄以岭药业有限公司 | Medicinal composition for restoring cardiac collaterals and its application |
| CN1403149A (en) * | 2002-10-24 | 2003-03-19 | 河北以岭医药研究院有限公司 | Medicines composition for treating chronic heart failure and its prepn |
Non-Patent Citations (2)
| Title |
|---|
| 王扬等.中医药治疗慢性心力衰竭临床研究进展.河北中医.2007,29(9),858-860. * |
| 陈一峰等.生脉散合苓桂术甘汤加味治疗慢性心力衰竭30例.实用中医内科杂志.2005,19(5),454. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101301458A (en) | 2008-11-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1305844A (en) | Medicine for treating congestive heart failure | |
| CN1895620A (en) | Chinese-medicinal composition for treating coronary heart disease | |
| CN104873705A (en) | Medicinal composition for treating angina pectoris of coronary heart disease and application thereof | |
| CN103432412B (en) | Medicament for treating hyperplasia of mammary glands and preparation method thereof | |
| CN105288208A (en) | Traditional Chinese medicine composition for treating acute optic neuritis | |
| CN102512552B (en) | Traditional Chinese medicine composition for treating exogenous fever | |
| CN103610936B (en) | A kind of Chinese medicine preparation and preparation method for the treatment of coronary heart disease | |
| CN101301458B (en) | Medicament for treating chronic cardiac failure and preparation thereof | |
| CN102988900B (en) | Traditional Chinese medicine enema used for treating senile functional constipation | |
| CN102335346A (en) | Traditional Chinese medicinal preparation for treating cerebrovascular disease | |
| CN101912434A (en) | Medicament for treating hypertension and insomnia and preparation method thereof | |
| CN104873911A (en) | Traditional Chinese medicine for oral administration for adjunctively treating sepsis | |
| CN105343866A (en) | Traditional Chinese medicine tablets for treating cold rheum coughs and preparation method | |
| CN104940766A (en) | Dendrobium officinale traditional Chinese medicine composition for conditioning sub-health | |
| CN100558387C (en) | The Chinese medicinal capsule of treatment heart failure | |
| CN104857121A (en) | Drug combination for curing hyperlipidemia and application thereof | |
| CN102908607A (en) | External traditional Chinese medicine for treating chronic simple rhinitis and preparation method thereof | |
| CN101167915B (en) | Traditional Chinese medicine for treating chronic superficial gastritis and its preparation method | |
| CN107617091A (en) | A kind of Chinese medicine composition for treating cold asthma | |
| CN106822852A (en) | Treat pharmaceutical composition, its preparation technology and the purposes of coronary heart disease | |
| CN110946905B (en) | Traditional Chinese medicine composition applied to acupuncture points of peritoneal dialysis patients and preparation method and application thereof | |
| CN101618187A (en) | Medicine for treating liver cancer and preparation method thereof | |
| CN105194526A (en) | Traditional Chinese medicine for treating hepatic calculi | |
| CN106038812A (en) | Traditional Chinese medicine capsule for reducing blood fat and removing atherosclerotic plaque | |
| CN107281419A (en) | One kind treats uremia Chinese herbal and crude drugs preparations and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100915 Termination date: 20110619 |