CN106038812A - Traditional Chinese medicine capsule for reducing blood fat and removing atherosclerotic plaque - Google Patents
Traditional Chinese medicine capsule for reducing blood fat and removing atherosclerotic plaque Download PDFInfo
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Classifications
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- A61K35/56—Materials from animals other than mammals
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Abstract
The invention relates to a traditional Chinese medicine capsule for reducing blood fat and removing atherosclerotic plaque, belonging to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine capsule is prepared from the following raw materials by weight: 30 to 40 parts of yeast powder, 11 to 21 parts of prepared rhubarb, 5 to 15 parts of pseudo-ginseng, 3 to 10 parts of glutinous rehmannia, 4 to 15 parts of prepared leech, 1 to 10 parts of stir-fried ground beetle, 1 to 9 parts of stir-fried gadfly, 1 to 8 parts of calcined dried lacquer, 1 to 5 parts of licorice root, 2 to 7 parts of root of large-flowered skullcap, 2 to 10 parts of peach seed, 5 to 10 parts of safflower and 5 to 10 parts of stir-fried bitter apricot kernel. The yeast powder, rhubarb, leech, ground beetle and gadfly in the capsule are used for reducing blood fat, removing plaque and resisting hemagglutination; removed plaque will not form thrombus, so blood vessels will not be blocked; lipid deposition in a body is reduced; metabolic disorders of a body are adjusted; oxidation damage is mitigated; and inflammatory response is inhibited. The root of large-flowered skullcap in the raw materials exerts anti-inflammation effect. The pseudo-ginseng, peach seed, dried lacquer, safflower and bitter apricot kernel are capable of activating blood circulation to dissipate blood stasis. Through combined usage of the bulk drugs, the prepared traditional Chinese medicine capsule is capable of reducing blood fat and removing atherosclerotic plaque and has good clinical application effect.
Description
Technical field
The present invention relates to a kind of for blood fat reducing, the Chinese medicinal capsule of dispelling atheromatous plaque, belong to Chinese medicine preparation
Technical field.
Background technology
Atherosclerosis is the commonly encountered diseases of harm human health and life and high morbidity, and different because of hardening position are led
The disease caused would also vary from:
(1) if hardening occurs at heart coronary artery, then it is called coronary heart disease, can cause sudden during Severe blockage blood vessel
Extremely, along with the continuous progress of modern medical science level, coronary disease sufferer can be saved by the way of mounting bracket or bridging
The life of person；
(2) if hardening occurs at cerebral arteries, dizziness, dizzy can be caused, brain thin vessels time serious, can be blocked, form brain
Stalk, causes hemiplegia, serious threat to life safety；
(3) if hardening occurs at femoral artery, lower limb blood supply insufficiency can be caused, can affect on foot time serious；
(4) if hardening occurs at kidney, renal hypertension disease can be caused.
Gradually step into aging society along with China, atherosclerotic sickness rate has reached 11% left side of population
Right, it is therefore desirable to it is paid attention to further.In prior art, in addition to operative treatment, although treat atherosclerotic medicine
Thing preparation is numerous many, but weak curative effect, relapse rate are high, have side effect etc. to become the subject matter of puzzlement patient.
Summary of the invention
It is an object of the invention to provide a kind of for blood fat reducing, the Chinese medicinal capsule of dispelling atheromatous plaque, have
Effect that instant effect, relapse rate are low, toxic and side effects is few.
Of the present invention for blood fat reducing, the Chinese medicinal capsule of dispelling atheromatous plaque, by following parts by weight
Raw material make:
Yeast mycopowder 30-40 part, Radix Et Rhizoma Rhei 11-21 part, Radix Notoginseng 5-15 part, Radix Rehmanniae 3-10 part, Hirudo (processed) 4-15 part, fry soil
Unit's 1-10 part, fries Tabanus 1-9 part, forges Resina Toxicodendri 1-8 part, Radix Glycyrrhizae 1-5 part, Radix Scutellariae 2-7 part, Semen Persicae 2-10 part, Flos Carthami 5-10 part, fries
Semen Armeniacae Amarum 5-10 part.
Described Chinese medicinal capsule can also be made up of the raw material of following parts by weight:
Yeast mycopowder 35-40 part, Radix Et Rhizoma Rhei 16-21 part, Radix Notoginseng 10-15 part, Radix Rehmanniae 7-10 part, Hirudo (processed) 10-15 part, fry
Eupolyphaga 5-10 part, fries Tabanus 5-9 part, forges Resina Toxicodendri 5-8 part, Radix Glycyrrhizae 3-5 part, Radix Scutellariae 4-7 part, Semen Persicae 6-10 part, Flos Carthami 8-10 part,
Stir-baked SEMEN ARMENIACAE AMARUM 8-10 part.
Described Chinese medicinal capsule can also be made up of the raw material of following parts by weight:
Yeast mycopowder 30-35 part, Radix Et Rhizoma Rhei 11-16 part, Radix Notoginseng 5-11 part, Radix Rehmanniae 3-7 part, Hirudo (processed) 4-10 part, fry soil
Unit's 1-5 part, fries Tabanus 1-5 part, forges Resina Toxicodendri 1-5 part, Radix Glycyrrhizae 1-3 part, Radix Scutellariae 2-4 part, Semen Persicae 2-6 part, Flos Carthami 5-8 part, fries Fructus Pruni
Core 5-8 part.
The preparation method of described Chinese medicinal capsule, is after each raw material is first carried out in accordance with regulations clean system, the process of preparing Chinese medicine:
(1) by the Radix Et Rhizoma Rhei of proportional quantity, Semen Persicae, Radix Scutellariae, Radix Rehmanniae, forge Resina Toxicodendri, Radix Glycyrrhizae, Flos Carthami, stir-baked SEMEN ARMENIACAE AMARUM mixing after use water
Or the ethanol solution that concentration is 45wt% extracts 2 times, each 1.5-2h, to filter after united extraction liquid, filtrate is dense through economic benefits and social benefits
After contracting, microwave vacuum drying, pulverizing, obtain dried cream powder, standby；
Wherein, baking temperature during microwave vacuum drying is 80-90 DEG C, controls moisture ＜ 3%；
(2) by the yeast mycopowder of proportional quantity, Radix Notoginseng, Hirudo (processed), stir-fry eupolyphaga, fry Tabanus to be crushed to particle diameter be 100-150 mesh
Fine powder, then it is mixed with dried cream powder；
(3) mixed fine medicinal material powder is loaded capsule by regulation, obtain for blood fat reducing after the assay was approved, dispel tremulous pulse
The Chinese medicinal capsule of atherosclerotic plaque.
Packing specification: 0.5g/ grain
Usage: taken three times per day, 3-5 tablet/time
Carotid arterial atherosclerosis is considered to reflect " window " of whole body As pathological changes, therefore just can be reflected by its change
The curative effect of medicine.
Dispel atheromatous plaque clinical observation on the therapeutic effect:
The Chinese medicinal capsule of the application present invention, treatment has patient 9 example of carotid atherosclerotic plaque, patient 1 example of Arterial plaque of lower extremity,
In this 10 example patient, minimum 65 years old of age, maximum 82 years old, average 75 years old, wherein, male 5 people, women 5 people, suffers from the most per capita
There are hypertension, coronary heart disease, cerebral infarction or myocardial infarction.
Treatment situation is as follows:
Therapeutic Method: each 5 of each patient, three times a day, ante cibum, oral meal, it is administered orally and within two months, is one
The course for the treatment of.
Curative effect determinate standard is:
Clinical cure: subjective symptoms sign disappears, training check result continuous 3 times in range of normal value, and can consolidate；
Effective: subjective symptoms sign major part disappears, training checks that result is clearly better, normal or close normal；
Effective: subjective symptoms sign is obviously improved, training checks that result has taken a turn for the better；
Invalid: before and after treatment, symptom and sign and training check that numerical value is substantially without improving.
Detection method: use high-resolution ultrasonic, the speckle calculated by the longest and the shortest by the speckle measured
Block area, to before taking medicine with take medicine after plaque area contrast.
Therapeutic outcome: effective 7 examples, invalid 3 examples.In 3 invalid examples, 2 examples suffer from old myocardial infarction and cerebral infarction,
1 example suffers from coronary heart disease, hypertension, cerebral infarction；In effective 7 examples, speckle reduce more than 40% have 2 examples, reduce 30% with
On have 4 examples, reduce more than 20% have 6 examples；Reduce more than 10% have 7 examples；
Side effect: in 2 months of this 10 example patient, does not finds the side effect of any discomfort, and a lot of patient exists
The phenomenon of constipation, abdominal distention is also eliminated after taking medicine.
Model case:
1, king so-and-so, man, 78 years old, before treatment, color ultrasonic diagnosis showed: left and right common carotid artery crotch is visited and multiple respectively
Strong echo speckle, big person is positioned at right carotid crotch about 4.3 × 2.2mm, takes the Chinese medicinal capsule of the present invention after 60 days,
Color ultrasonic diagnosis shows: left and right common carotid artery crotch is visited and 3.5 × 1.6mm, 3 × 1.4mm strong echo speckle respectively.
2, grandson so-and-so, female, 67 years old, before treatment, color ultrasonic diagnosis showed: left and right common carotid artery crotch visits and 5.8 respectively ×
2.2mm, 2 × 1mm strong echo speckle, took the Chinese medicinal capsule of the present invention after 60 days, and color ultrasonic diagnosis shows: left common carotid artery bifurcated
Place is visited and 3.8 × 0.7mm strong echo speckle.
3, king so-and-so, female, 71 years old, before treatment, color ultrasonic diagnosis showed: left and right common carotid artery crotch visits and 9.6 respectively ×
3.7mm, 9 × 3mm strong echo speckle, took the Chinese medicinal capsule of the present invention after 60 days, and color ultrasonic diagnosis shows: common carotid artery crotch
Visit and irregular strong echo speckle, big person: right side 2.4 × 0.9mm, left side 5.1 × 1.7mm.
4, Sui so-and-so, female, 66 years old, before treatment, color ultrasonic diagnosis showed: adhere to strong echo speckle on right common carotid artery inner membrance,
Size is 9.7 × 1.7mm, takes the Chinese medicinal capsule of the present invention after 60 days, and color ultrasonic diagnosis shows: right common carotid artery crotch visit and
Big person about 3.9 × 1.6mm strong echo speckle.
The atherosclerotic medicine for the treatment of of research at present all can only play stable speckle, the merit of suppression plaque progression
Effect, including the widest lipid-lowering statins of domestic and international application, and verified, the Chinese medicinal capsule of the present invention then can be obviously reduced
The area of patient's speckle.
Blood fat reducing clinical observation on the therapeutic effect:
Application the present invention Chinese medicinal capsule, carried out altogether 13 example observation of curative effect test, patient age 56-70 year between,
Wherein 9 example male, 4 example women.Taking the Chinese medicinal capsule of the present invention after two months, understood by the examining report list of hospital
Patient take medicine before and after the situation of change of lipid examination result.
Lipid examination index Normal reference range: T-CHOL≤5.70mmol/L, triglyceride≤1.70mmol/L,
High density lipoprotein >=1.15mmol/L, low-density lipoprotein cholesterol≤4.11mmol/L.
Curative effect: by the treatment of 13 hyperlipemic patients is shown, the Chinese medicinal capsule of the present invention can effectively reduce blood fat:
T-CHOL averagely reduces by 18.46%, and triglyceride averagely reduces by 32.33%, and low-density lipoprotein cholesterol averagely reduces
41.65%, high density lipoprotein averagely raises 15.29%.
Model case:
1, Korea Spro so-and-so, female, 58 years old, before treatment, T-CHOL 3.78mmol/L, triglyceride 1.82mmol/L, low-density
Lipoprotein cholesterol 3.1mmol/L, HDL1 .12mmol/L, take the Chinese medicinal capsule of the present invention after 60 days, total gallbladder
3.2mmol/L is down to by sterin, and triglyceride is down to 1.68mmol/L, and low-density lipoprotein cholesterol is down to 2.78mmol/L, high
Density lipoprotein rises to 1.30mmol/L.
2, Ma, female, 62 years old, before treatment, T-CHOL 7.23mmol/L, triglyceride 3.56mmol/L, low-density
Lipoprotein cholesterol 3.10mmol/L, HDL1 .89mmol/L, take the Chinese medicinal capsule of the present invention after 60 days, total gallbladder
5.89mmol/L is down to by sterin, and triglyceride is down to 3.02mmol/L, and low-density lipoprotein cholesterol is down to 2.78mmol/L, high
Density lipoprotein rises to 2.0mmol/L.
3, high so-and-so, man, 63 years old, before treatment, T-CHOL 4.98mmol/L, triglyceride 2.83mmol/L, low-density
Lipoprotein cholesterol 2.57mmol/L, HDL1 .35mmol/L, take the Chinese medicinal capsule of the present invention after 60 days, total gallbladder
3.83mmol/L is down to by sterin, and triglyceride is down to 1.72mmol/L, and low-density lipoprotein cholesterol is down to 2.03mmol/L, high
Density lipoprotein rises to 1.68mmol/L.
4, Ruan so-and-so, man, 70 years old, before treatment, T-CHOL 5.89mmol/L, triglyceride 3.95mmol/L, low-density
Lipoprotein cholesterol 3.12mmol/L, HDL1 .89mmol/L, take the Chinese medicinal capsule of the present invention after 60 days, total gallbladder
4.78mmol/L is down to by sterin, and triglyceride is down to 2.81mmol/L, and low-density lipoprotein cholesterol is down to 2.87mmol/L, high
Density lipoprotein rises to 2.13mmol/L.
Current research is thought, atheromatous plaque be formed with many reasons, the fat caused such as blood fat height
Matter infiltration, cell adhesion inflammatory factor, the migration of smooth muscle cell and propagation etc..It is former that the present invention is based on above-mentioned multiple formation
Thus develop: yeast mycopowder, Radix Et Rhizoma Rhei, Hirudo, eupolyphaga, Tabanus are for blood fat reducing, speckle dispelling block, anticoagulant, the speckle dispelled
Thrombosis will not be formed, also cannot block blood vessel, decrease internal lipidosis, regulate organism metabolic disorder, alleviate oxidation
Damage, suppresses inflammatory reaction, and the Radix Scutellariae in raw material can play the effect of antiinflammatory, Radix Notoginseng, Semen Persicae, Resina Toxicodendri, Flos Carthami, Semen Armeniacae Amarum simultaneously
Having the effect of blood circulation promoting and blood stasis dispelling, above-mentioned all medicines share the effect playing blood fat reducing speckle dispelling altogether.
Beneficial effects of the present invention is as follows:
The invention belongs to pure Chinese medicine capsule, give full play to the blood fat reducing of Chinese medicine, speckle dispelling block, anticoagulant, blood circulation promoting and blood stasis dispelling
Function, curative effect is obvious, and not it has been found that obvious toxic and side effects, medication is convenient, and formula medical material is inexpensive, be easy to get.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described further.
Embodiment 1
For blood fat reducing, the Chinese medicinal capsule of dispelling atheromatous plaque, raw material dosage is as follows:
Yeast mycopowder 35 parts, Radix Et Rhizoma Rhei 15 parts, Radix Notoginseng 10 parts, Radix Rehmanniae 7 parts, Hirudo (processed) 10 parts, fry eupolyphaga 5 parts, fry Tabanus 5
Part, forge Resina Toxicodendri 4 parts, 3 parts of Radix Glycyrrhizae, Radix Scutellariae 4 parts, 6 parts of Semen Persicae, 8 parts of Flos Carthami, stir-baked SEMEN ARMENIACAE AMARUM 8 parts.
Preparation method is after each raw material is first carried out in accordance with regulations clean system, the process of preparing Chinese medicine:
(1) by the Radix Et Rhizoma Rhei of proportional quantity, Semen Persicae, the Radix Astragali, Radix Rehmanniae, forge Resina Toxicodendri, Radix Glycyrrhizae, Flos Carthami, stir-baked SEMEN ARMENIACAE AMARUM mixing after use water
Extracting 2 times, each 1.8h, filter after united extraction liquid, filtrate, after economic benefits and social benefits concentration, microwave vacuum drying, pulverizing, obtains
Dried cream powder, wherein, baking temperature is 85 DEG C, controls moisture ＜ 3%；
(2) by the yeast mycopowder of proportional quantity, Radix Notoginseng, Hirudo (processed), stir-fry eupolyphaga, fry snakeworm to be crushed to particle diameter be 100-150 mesh
Fine powder, then it is mixed with dried cream powder；
(3) mixed fine medicinal material powder is loaded capsule by regulation, obtain for blood fat reducing after the assay was approved, dispel tremulous pulse
The Chinese medicinal capsule of atherosclerotic plaque.
This Chinese medicinal capsule is applied to treat blood fat height, atheromatous plaque, once by trade name " blood vessel open capsule "
And obtain promising result.
Embodiment 2
For blood fat reducing, the Chinese medicinal capsule of dispelling atheromatous plaque, raw material dosage is as follows:
Yeast mycopowder 30 parts, Radix Et Rhizoma Rhei 11 parts, Radix Notoginseng 5 parts, Radix Rehmanniae 3 parts, Hirudo (processed) 4 parts, fry eupolyphaga 1 part, fry Tabanus 1
Part, forge Resina Toxicodendri 1 part, 1 part of Radix Glycyrrhizae, Radix Scutellariae 2 parts, 2 parts of Semen Persicae, 5 parts of Flos Carthami, stir-baked SEMEN ARMENIACAE AMARUM 5 parts.
Preparation method is with embodiment 1.
Embodiment 3
For blood fat reducing, the Chinese medicinal capsule of dispelling atheromatous plaque, raw material dosage is as follows:
Yeast mycopowder 32 parts, Radix Et Rhizoma Rhei 13 parts, Radix Notoginseng 7 parts, Radix Rehmanniae 5 parts, Hirudo (processed) 7 parts, fry eupolyphaga 3 parts, fry Tabanus 3
Part, forge Resina Toxicodendri 3 parts, 2 parts of Radix Glycyrrhizae, Radix Scutellariae 3 parts, 4 parts of Semen Persicae, 7 parts of Flos Carthami, stir-baked SEMEN ARMENIACAE AMARUM 7 parts.
Preparation method is with embodiment 1.
Embodiment 4
For blood fat reducing, the Chinese medicinal capsule of dispelling atheromatous plaque, raw material dosage is as follows:
Yeast mycopowder 37 parts, Radix Et Rhizoma Rhei 18 parts, Radix Notoginseng 12 parts, Radix Rehmanniae 9 parts, Hirudo (processed) 12 parts, fry eupolyphaga 8 parts, fry Tabanus 7
Part, forge Resina Toxicodendri 6 parts, 4 parts of Radix Glycyrrhizae, Radix Scutellariae 5 parts, 8 parts of Semen Persicae, 9 parts of Flos Carthami, stir-baked SEMEN ARMENIACAE AMARUM 9 parts.
Preparation method is with embodiment 1.
Embodiment 5
Yeast mycopowder 40 parts, Radix Et Rhizoma Rhei 21 parts, Radix Notoginseng 15 parts, Radix Rehmanniae 10 parts, Hirudo (processed) 15 parts, fry eupolyphaga 10 parts, fry horsefly
Worm 9 parts, forges Resina Toxicodendri 8 parts, 5 parts of Radix Glycyrrhizae, Radix Scutellariae 7 parts, 10 parts of Semen Persicae, 10 parts of Flos Carthami, stir-baked SEMEN ARMENIACAE AMARUM 10 parts.
Preparation method is with embodiment 1.
Claims (5)
1. one kind for blood fat reducing, dispel the Chinese medicinal capsule of atheromatous plaque, it is characterised in that: by following parts by weight
Raw material make:
Yeast mycopowder 30-40 part, Radix Et Rhizoma Rhei 11-21 part, Radix Notoginseng 5-15 part, Radix Rehmanniae 3-10 part, Hirudo (processed) 4-15 part, fry eupolyphaga 1-
10 parts, fry Tabanus 1-9 part, forge Resina Toxicodendri 1-8 part, Radix Glycyrrhizae 1-5 part, Radix Scutellariae 2-7 part, Semen Persicae 2-10 part, Flos Carthami 5-10 part, stir-baked SEMEN ARMENIACAE AMARUM
5-10 part.
The most according to claim 1 for blood fat reducing, the Chinese medicinal capsule of dispelling atheromatous plaque, its feature exists
In: it is made up of the raw material of following parts by weight:
Yeast mycopowder 35-40 part, Radix Et Rhizoma Rhei 16-21 part, Radix Notoginseng 10-15 part, Radix Rehmanniae 7-10 part, Hirudo (processed) 10-15 part, fry eupolyphaga
5-10 part, fries Tabanus 5-9 part, forges Resina Toxicodendri 5-8 part, Radix Glycyrrhizae 3-5 part, Radix Scutellariae 4-7 part, Semen Persicae 6-10 part, Flos Carthami 8-10 part, fries Fructus Pruni
Core 8-10 part.
The most according to claim 1 for blood fat reducing, the Chinese medicinal capsule of dispelling atheromatous plaque, its feature exists
In: it is made up of the raw material of following parts by weight:
Yeast mycopowder 30-35 part, Radix Et Rhizoma Rhei 11-16 part, Radix Notoginseng 5-11 part, Radix Rehmanniae 3-7 part, Hirudo (processed) 4-10 part, fry eupolyphaga 1-5
Part, fry Tabanus 1-5 part, forge Resina Toxicodendri 1-5 part, Radix Glycyrrhizae 1-3 part, Radix Scutellariae 2-4 part, Semen Persicae 2-6 part, Flos Carthami 5-8 part, stir-baked SEMEN ARMENIACAE AMARUM 5-8
Part.
The most according to claim 1 for blood fat reducing, the Chinese medicinal capsule of dispelling atheromatous plaque, its feature exists
In: preparation method is after each raw material is first carried out in accordance with regulations clean system, the process of preparing Chinese medicine:
(1) by the Radix Et Rhizoma Rhei of proportional quantity, Semen Persicae, Radix Scutellariae, Radix Rehmanniae, forge after Resina Toxicodendri, Radix Glycyrrhizae, Flos Carthami, stir-baked SEMEN ARMENIACAE AMARUM mixing with water or dense
Degree for 45wt% ethanol solution extract 2 times, each 1.5-2h, filter after united extraction liquid, filtrate through economic benefits and social benefits concentrate, micro-
After ripple vacuum drying, pulverizing, obtain dried cream powder, standby；
(2) by the yeast mycopowder of proportional quantity, Radix Notoginseng, Hirudo (processed), stir-fry eupolyphaga, fry Tabanus to be crushed to particle diameter be that 100-150 purpose is thin
Powder, then mixes it with dried cream powder；
(3) mixed fine medicinal material powder is loaded capsule by regulation, obtain for blood fat reducing after the assay was approved, dispel tremulous pulse medicated porridge sample
The Chinese medicinal capsule of plaque.
The most according to claim 4 for blood fat reducing, the Chinese medicinal capsule of dispelling atheromatous plaque, its feature exists
In: baking temperature during microwave vacuum drying in step (1) is 80-90 DEG C, controls moisture ＜ 3%.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107496683A (en) * | 2017-10-11 | 2017-12-22 | 苏州和必尔斯电子科技有限公司 | A kind of Chinese medicine composition for treating high fat of blood and preparation method thereof |
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| CN103142750A (en) * | 2011-12-07 | 2013-06-12 | 西安泰科迈医药科技有限公司 | Rhubarb and eupolnhagea oral liquid and preparation method thereof |
| CN104606251A (en) * | 2015-03-05 | 2015-05-13 | 济南康众医药科技开发有限公司 | Pharmaceutical composition without ground beeltle peculiar smell |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107496683A (en) * | 2017-10-11 | 2017-12-22 | 苏州和必尔斯电子科技有限公司 | A kind of Chinese medicine composition for treating high fat of blood and preparation method thereof |
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Address after: 255086 Zibo Industrial Zone, Shandong high tech Road, No. 3133 Applicant after: Zibo Yada pharmaceutical Limited by Share Ltd Address before: 255086 Shandong Province, Zibo city high tech Development Zone Taimeilu No. 8-1 Applicant before: Yada Pharmaceuticals Co., Ltd. Of Wenzhou Economic & Technical Development Zone |
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