CN101342346A - Drop pill for treating stenocardia caused by coronary disease - Google Patents
Drop pill for treating stenocardia caused by coronary disease Download PDFInfo
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Abstract
The present invention discloses a dropping pill used to cure the angina pectoris caused by coronary heart disease, which belongs to the technical field of Chinese herbal preparations. After being extracted from eleven traditional Chinese medicine material components including radix astragali, radix salviae miltiorrhizae, radix puerariae, rhizoma ligustici wallichii, cassia twig, radix notoginseng, rhizoma corydalis, angelica dahurica, borneol, rhizoma pinelliae preparata and nutmeg, a medical active ingredients are mixed with a single or mixed matrix(es) of polyethyleneglycol with a molecular weight between 4000 and 10000, which is then stirred so that the active medical ingredient is dissolved or suspended, and a self-made or universal dropping pill machine drops the solution into condensing agent, so that the solution is condensed to prepare the dropping pill. The dropping pill, which has functions including supplementing qi and activating blood circulation, dredging vessels and relieving pain and relieving the chest stuffiness and resolving phlegm to reduce turbidity, is used to cure the angina pectoris caused by coronary heart disease, and compared with the like preparations, the dropping pill is characterized by good healing effect, high bioavailability, quick and persistent effect, stable process, convenient operation, etc.
Description
Technical field
The present invention relates to a kind of anginal drop pill that coronary heart disease causes that is used for the treatment of, belong to the Chinese medicine preparation technical field.
Technical background
Angina pectoris is the modal Clinical types of coronary heart disease, is owing to coronary insufficiency, rapid, temporary transient ischemia of cardiac muscle and the caused clinical syndrome of anoxia.Primary disease is more common in the male, most of patients 40 years old with sequela, tired, excited, be satiated with food, catch cold, rainy weather, acute circulatory failure etc. are common inducement.
Angina pectoris belongs to the traditional Chinese medical science " obstruction of qi in the chest and cardialgia ", " angina pectoris " category.It is generally acknowledged how weakly with age, surfeit delicious food savoury due to the feelings will internal injury, belongs to the card of deficiency in origin and excess in superficiality.Deficiency in origin refers to insufficiency of heart-QI, deficiency of heart-YANG, deficiency of heart-yin, and mark refers to blood stasis, phlegm stagnancy, cold stagnating in fact.Primary disease has the inclination to tire out, lose heart all the time, is levying of the deficiency of vital energy; Pained position is constant, is resembling of blood stasis, so primary disease generally is basic pathogenesis with the blood stasis due to qi deficiency.The deficiency of vital energy or double yang deficiency, the deficiency of YIN, blood stasis or folder phlegm-damp, cold stagnating, this mark reciprocal causation causes the retardance of heart arteries and veins, so that stagnation of QI and blood may bring about pain, not flourish also pain, be generation pained by.
The generation of coronary heart disease and inward invasion of pathogenic cold, overstrain, intemperance of taking food, disorder of emotion, old etc. relevant, blockage of the cardiac vessels is its main pathogenesis, deficiency in origin and excess in superficiality is its basic pathogenesis.Dong Jianhua thinks that pathogenesis always belongs to deficiency in origin and excess in superficiality, and void is empty for negative and positive of qi and blood loses; Real is YIN-cold, turbid, the blood stasis of expectorant, so treatment is a basic principle with benefiting QI for activating blood circulation, a surname's numbness eliminating phlegm often.Deng Tietao thinks the southern climates humidity, and easily accumulatively wet raise phlegm is main so expectorant is controlled in promotion in early days.Ma Li etc. think that deficiency of qi and blood is this, and qi depression to blood stasis is for mark, so with inrigorating qi and promoting blood circulation, regulating QI to relieve pain is a method.Chen Keji thinks that the overall process that runs through incidence of coronary heart disease of blood stasis, blood circulation promoting and blood stasis dispelling are the general rules of treatment coronary heart disease, but can not ignore the turbid wet resistance of expectorant, and the diuretic of emphasizing to eliminate the phlegm is wet lays equal stress on blood circulation promoting and blood stasis dispelling.Yao Zupei etc. think no matter primary disease is that void is real, and no matter what heresy is to suffer from, and the resistance of the heart arteries and veins stasis of blood is still its main pathological basis, and treatment is worked as based on the blood stasis dispelling meridianactivating method, symptomatic treatment in acute condition, and through preventing and treating the whole story.Wu Yueping thinks that primary disease is this with the deficiency of vital energy, is mark with the blood stasis, and for resembling, clinical treatment be crucial with the activating blood circulation method, and the method for dispeling the wind also plays an important role in the treatment of obstruction of qi in the chest and cardialgia based on air-supplementing method with pneumatic.Xu Fengqin etc. think that the coronary heart disease yin deficiency syndrome is quite a few and see that the patients with coronary heart disease age is many more than 40 years old, half of YIN QI consumed, but excited all heat-transformation impairment of YINs of eating and drinking without temperance in addition.Xu Yuhua thinks that the cause of disease is that the hepatic and renal YIN deficiency, heart deficiency of kidney-QI, the blood vessels stasis of blood stagnate, thus reinforcing the heart gas taste the heart-yin, nourishing kidney-yin kidney-replenishing to effect a permanent cure, the activating blood circulation to dissipate blood stasis and dredge the collateral pain relieving is to take stopgap measures.The core that Yang Peijun proposes coronary heart disease " deficiency in origin " is expectorant, stasis of blood stagnating heart meridian for the core of suffer from a deficiency of the kidney ", mark is real ", and treatment should be aided with the blood stasis dispelling of eliminating the phlegm, declare the numbness collateral dredging based on the multiple motive of reinforcing kidney and strengthening resistance.Yu Zhiqiang discusses the disease of effecting a permanent cure from liver, and he thinks that the liver failing to maintain the normal flow of QI is that cause of coronary heart disease is basic, and the catharsis function of liver is normal, then unblocked, the meridians tonneau of cloth is failed in the operation of energy and blood of human body body fluid, and internal organs are in harmonious proportion, otherwise then deteriorated case is grown thickly, so-called " liver is for passing the source of disease, and the heart is the institute of biography disease ".Think that also disorder of emotion, overwork, diet satiety, climate change are inducement, the importance of strong regulating spirit and emotion by oneself factor in the pathogenic process of angina pectoris.Cao Jing also controls the thoracic obstruction from the liver opinion, proposes stagnation of QI due to depression of the liver, and QI and blood must not reach by happy accent, and numbness resistance heart arteries and veins is the important pathogenesis that angina pectoris takes place, and advocates with soothing liver-QI for relieving depression, regulating the flow of QI to dissipate blood stasis to be method of treatment.Dai Guohua proposes coronary heart disease syndrome caused by wind pathogen theory, thinks that the imbalance of heart kidney, the stagnant windage of arteries and veins are the main pathogenesis of coronary heart disease, should be with dispelling wind and removing obstruction in the collateral, the legislation of tonifying Qi of the kidney.
Summary of the invention
The technical problem that the present invention solves is that to overcome existing preparation onset slow, and deficiencies such as unsatisfactory curative effect provide a kind of novel medicament preparation---drop pill.
A kind of anginal drop pill that coronary heart disease causes that is used for the treatment of of the present invention, it is made up of Chinese medicine extract that contains effective composition and substrate.
Wherein containing the Chinese medicine extract of effective composition and the weight ratio of substrate is 1: 1～2: 9.
And substrate is Polyethylene Glycol; Can be that molecular weight polyethylene glycol is any substrate of any one or two kinds of above mixture in 4000～10000.
The Chinese medicine extract that wherein contains effective composition is extracted by following Chinese medicine raw materials by weight proportion to be processed and gets:
2～15 parts of 9～36 parts of Rhizoma Chuanxiongs of 6～15 parts of Radix Puerariaes of 2～12 parts of Radix Salviae Miltiorrhizaes of the Radix Astragali
2～15 parts of 6～22 parts of Radixs Angelicae Dahuricae of 1～12 part of Rhizoma Corydalis of 4～27 portions of Radix Notoginseng of Ramulus Cinnamomi
4～12 parts of 6～27 parts of Semen Myristicaes of 1～12 part of Rhizoma Pinelliae Preparatum of Borneolum Syntheticum
And the optimum weight proportioning of stating each raw material of Chinese medicine component is:
6 parts of 27 parts of Rhizoma Chuanxiongs of 12 parts of Radix Puerariaes of 9 parts of Radix Salviae Miltiorrhizaes of the Radix Astragali
12 parts of 15 parts of Radixs Angelicae Dahuricae of 6 parts of Rhizoma Corydalis of 19 portions of Radix Notoginseng of Ramulus Cinnamomi
8 parts of 15 parts of Semen Myristicaes of 5 parts of Rhizoma Pinelliae Preparatum of Borneolum Syntheticum
The preparation technology of this drop pill is:
(1) Borneolum Syntheticum is ground into fine powder, all the other each medicine pulverize separately become coarse powder, cross 10～50 mesh sieves, and are standby;
(2) take by weighing Rhizoma Chuanxiong, Ramulus Cinnamomi, Semen Myristicae by formula proportion, mix, extract volatile oil with steam distillation, collect volatile oil, medicinal residues and water liquid are standby;
(3) get Radix Salviae Miltiorrhizae, Rhizoma Corydalis, the Radix Angelicae Dahuricae, mix, add 60～80% alcohol heating reflux and extract three times, extracted respectively 2,1,1 hours, merge alcohol extract (medicinal residues are standby), filter, decompression filtrate recycling ethanol also is condensed into clear paste, alcohol-extracted extract is standby;
(4) all the other Radixs Astragali, Radix Puerariae etc. four flavor coarse powder mix in the side of getting, decoct with water 3 hours after, add medicinal residues after the alcohol extraction of the medicinal residues of (2) and water liquid and (3), fried in shallow oil altogether again 2 hours, put cold filtration, filtrate is concentrated into the clear paste that relative density is 1.12～1.18 (60 ℃), and is standby;
(5) get (3) alcohol-extracted extract that makes and clear paste that (4) make, mix,, pulverize the powder that gets dry extract in 70 ℃ of drying under reduced pressure, standby;
(6) in proportion, dried cream powder is added in the single or mixed-matrix of fused Polyethylene Glycol, stir and make its dissolving or suspendible, add volatile oil and Borneolum Syntheticum fine powder, mixing, 40～70 ℃ of insulations splash into it in 0～10 ℃ the liquid paraffin condensed fluid with self-control or general drop pill machine, condensation is shrunk to ball, wash ball with liquid paraffin, wipe the liquid paraffin on drop pill surface then away, select ball, packing after the assay was approved, promptly.
The drop pill that the present invention makes has the function of benefiting QI for activating blood circulation, coronary circulation-promoting pain-relieving, the chest stuffiness relieving resolving phlegm lowering turbidity, is used for the treatment of the angina pectoris that coronary heart disease causes.Compare with similar preparation, it has following advantage:
(1) this product is a pure Chinese medicinal preparation, and side effect is little, and has no drug resistance.Be suitable for the diabetics use and stimulate less intestinal.Clinical trial shows can effectively expand coronary vasodilator, blood flow increasing.Uncomfortable in chest and the angina pectoris cure rate that coronary heart disease is caused reaches 94.6%, and the effective percentage of hypercholesterolemia and hypertriglyceridemia is reached 82.3%.
(2) product efficacy characteristics: this drop pill good effect, the bioavailability height, effect is fast and lasting, has process stabilizing, characteristics such as easy to operate.
(3) product is suitable for the crowd: 1. hypertension, patients with coronary heart disease; 2. the higher crowd of blood fat; 3. diabetics; 4. middle-aged and elderly people patient.
In order to ensure the clinical efficacy of this drop pill, carried out following clinical research:
1. physical data
This organizes 232 examples, all derive from the hospital outpatient patient, angina pectoris attacks is in various degree all arranged, and diagnosis of coronary heart disease meets the diagnostic criteria of therapy of combining Chinese and Western medicine angina pectoris in 1979 and arrhythmia research forum revision, and typical ECG change or coronarography result are all arranged.The patient is divided into treatment group and matched group at random.128 examples are organized in treatment, man 87 years old, 41 of woman.52～65 years old age, average (60 ± 2.6) year 104 of matched groups, 67 of men, 37 of woman, 54～64 years old age t average (59 ± 2.4) year.Two groups of patient's clinical symptoms are similar, have comparability.
2. Therapeutic Method
2.1 require the other treatment angina pectoris medicine of stopping using in principle during all MethodsThe cases enrolled treatments, but give nitroglycerin in case of necessity.
2.2 two groups of (inosine 0.2gt every day 3 times, vitamin Bs on the conventional therapy basis
110mg, every day 3 times), treatment group oral this drop pill every day, each 4, every day 3 times; Matched group oral administered compound Radix Salviae Miltiorrhizae Tabellae each 4 times, every day 3 times, was for 4 weeks the course of treatment.
2.3 clinical symptoms before and after the observation index treatment, picture of the tongue, pulse condition. angina pectoris attacks situation, the variation of nitroglycerin consumption, electrocardiogram, hemorheology, total effects etc.
2.4 curative effect determinate standard
2.4.1 judging, angina pectoris and ECG curative effect carry out with reference to the WHO diagnostic criteria.
2.4.2 face to come cardinal symptom: feeling of oppression and pain in the chest, shortness of breath and palpitation, spontaneous perspiration, complexion are white. and the picture of the tongue pulse condition etc., adopt 1～4 fen sxemiquantitative integration method efficacy determination to be divided into produce effects according to weight: original symptom complete obiteration, total mark minimizing 〉=70{ is effective: original symptom obviously alleviates total mark and reduces between 40～69; Invalid: original symptom does not have and is clearly better, and total mark reduces＜40 and increases the weight of: have behind original symptom treatment and increase the weight of, total mark increases more than 10 before the treatment.
2.5 statistical analysis: measurement data adopts the t check, and enumeration data adopts the x check, and ranked data adopt the Ridit check.
3. result
The angina pectoris situation of change: 128 routine produce effects 75 examples (60.59%) are organized in treatment, effective 44 examples (32.38%), invalid 9 examples (3.03%), matched group 104 routine produce effects.
The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.Following example is based on the above-mentioned subject area of the present invention, but is not limited to following example.
The specific embodiment
[embodiment 1]
The prescription that adopts is formed and weight proportion is:
6 parts of 27 parts of Rhizoma Chuanxiongs of 12 parts of Radix Puerariaes of 9 parts of Radix Salviae Miltiorrhizaes of the Radix Astragali
12 parts of 15 parts of Radixs Angelicae Dahuricae of 6 parts of Rhizoma Corydalis of 19 portions of Radix Notoginseng of Ramulus Cinnamomi
8 parts of 15 parts of Semen Myristicaes of 5 parts of Rhizoma Pinelliae Preparatum of Borneolum Syntheticum
Its preparation technology is as follows:
(1) Borneolum Syntheticum is ground into fine powder for 5 parts, all the other each medicine pulverize separately become coarse powder, cross 24 mesh sieves, and are standby;
(2) take by weighing 6 parts of Rhizoma Chuanxiongs, 19 parts of Ramulus Cinnamomi, 8 parts of Semen Myristicaes by formula proportion, mix, extract volatile oil with steam distillation, collect volatile oil, medicinal residues and water liquid are standby;
(3) get 12 parts of Radix Salviae Miltiorrhizaes, 15 parts of Rhizoma Corydalis, 12 parts of the Radixs Angelicae Dahuricae, mix, add 75% alcohol heating reflux and extract three times, extracted respectively 2,1,1 hours, and merged alcohol extract (medicinal residues are standby), filter, decompression filtrate recycling ethanol also is condensed into clear paste, and it is standby to get alcohol-extracted extract;
(4) all the other Radixs Astragali, Radix Puerariae etc. four flavor coarse powder mix in the side of getting, decoct with water 3 hours after, add medicinal residues after the alcohol extraction of the medicinal residues of (2) and water liquid and (3), fried in shallow oil altogether again 2 hours, put cold filtration, filtrate is concentrated into the clear paste that relative density is 1.15 (60 ℃), and is standby;
(5) get (3) alcohol-extracted extract that makes and clear paste that (4) make, mix,, pulverize the powder that gets dry extract in 70 ℃ of drying under reduced pressure, standby;
(6) be 2: 9 in dried cream powder and substrate ratio, it is in 2000 and 6000 the mixed-matrix that dried cream powder is added fused molecular weight polyethylene glycol, stirs and makes its dissolving or suspendible, add volatile oil and Borneolum Syntheticum fine powder, mixing, 60 ℃ of insulations splash into it in 0 ℃ the liquid paraffin condensed fluid with general drop pill machine, condensation is shrunk to ball, wash ball with liquid paraffin, wipe the liquid paraffin on drop pill surface then away, select ball, packing after the assay was approved, promptly.
[embodiment 2]
The prescription that adopts is formed and weight proportion is:
9 parts of 15 parts of Rhizoma Chuanxiongs of 9 parts of Radix Puerariaes of 5 parts of Radix Salviae Miltiorrhizaes of the Radix Astragali
7 parts of 12 parts of Radixs Angelicae Dahuricae of 3 parts of Rhizoma Corydalis of 20 portions of Radix Notoginseng of Ramulus Cinnamomi
5 parts of 12 parts of Semen Myristicaes of 3 parts of Rhizoma Pinelliae Preparatum of Borneolum Syntheticum
Its preparation technology is as follows:
(1) Borneolum Syntheticum is ground into fine powder for 3 parts, all the other each medicine pulverize separately become coarse powder, cross 24 mesh sieves, and are standby;
(2) take by weighing 9 parts of Rhizoma Chuanxiongs, 20 parts of Ramulus Cinnamomi, 5 parts of Semen Myristicaes by formula proportion, mix, extract volatile oil with steam distillation, collect volatile oil, medicinal residues and water liquid are standby;
(3) get 9 parts of Radix Salviae Miltiorrhizaes, 12 parts of Rhizoma Corydalis, 7 parts of the Radixs Angelicae Dahuricae, mix, add 60% alcohol heating reflux and extract three times, extracted respectively 2,1,1 hours, and merged alcohol extract (medicinal residues are standby), filter, decompression filtrate recycling ethanol also is condensed into clear paste, and it is standby to get alcohol-extracted extract;
(4) all the other Radixs Astragali, Radix Puerariae etc. four flavor coarse powder mix in the side of getting, decoct with water 3 hours after, add medicinal residues after the alcohol extraction of the medicinal residues of (2) and water liquid and (3), fried in shallow oil altogether again 2 hours, put cold filtration, filtrate is concentrated into the clear paste that relative density is 1.16 (60 ℃), and is standby;
(5) get (3) alcohol-extracted extract that makes and clear paste that (4) make, mix,, pulverize the powder that gets dry extract in 70 ℃ of drying under reduced pressure, standby;
(6) be 1: 7 in dried cream powder and substrate ratio, it is in 4000 the substrate that dried cream powder is added fused molecular weight polyethylene glycol, stirs and makes its dissolving or suspendible, add volatile oil and Borneolum Syntheticum fine powder, mixing, 50 ℃ of insulations splash into it in 5 ℃ the liquid paraffin condensed fluid with homemade drop pill machine, condensation is shrunk to ball, wash ball with liquid paraffin, wipe the liquid paraffin on drop pill surface then away, select ball, packing after the assay was approved, promptly.
[embodiment 3]
The prescription that adopts is formed and weight proportion is:
12 parts of 30 parts of Rhizoma Chuanxiongs of 15 parts of Radix Puerariaes of 11 parts of Radix Salviae Miltiorrhizaes of the Radix Astragali
9 parts of 20 parts of Radixs Angelicae Dahuricae of 9 parts of Rhizoma Corydalis of 20 portions of Radix Notoginseng of Ramulus Cinnamomi
12 parts of 20 parts of Semen Myristicaes of 8 parts of Rhizoma Pinelliae Preparatum of Borneolum Syntheticum
Its preparation technology is as follows:
(1) Borneolum Syntheticum is ground into fine powder for 8 parts, all the other each medicine pulverize separately become coarse powder, cross 10 mesh sieves, and are standby;
(2) take by weighing 12 parts of Rhizoma Chuanxiongs, 20 parts of Ramulus Cinnamomi, 12 parts of Semen Myristicaes by formula proportion, mix, extract volatile oil with steam distillation, collect volatile oil, medicinal residues and water liquid are standby;
(3) get 15 parts of Radix Salviae Miltiorrhizaes, 20 parts of Rhizoma Corydalis, 9 parts of the Radixs Angelicae Dahuricae, mix, add 70% alcohol heating reflux and extract three times, extracted respectively 2,1,1 hours, and merged alcohol extract (medicinal residues are standby), filter, decompression filtrate recycling ethanol also is condensed into clear paste, and it is standby to get alcohol-extracted extract;
(4) all the other Radixs Astragali, Radix Puerariae etc. four flavor coarse powder mix in the side of getting, decoct with water 3 hours after, add medicinal residues after the alcohol extraction of the medicinal residues of (2) and water liquid and (3), fried in shallow oil altogether again 2 hours, put cold filtration, filtrate is concentrated into the clear paste that relative density is 1.12 (60 ℃), and is standby;
(5) get (3) alcohol-extracted extract that makes and clear paste that (4) make, mix,, pulverize the powder that gets dry extract in 70 ℃ of drying under reduced pressure, standby;
(6) be 2: 7 in dried cream powder and substrate ratio, it is in 8000 the substrate that dried cream powder is added fused molecular weight polyethylene glycol, stirs and makes its dissolving or suspendible, add volatile oil and Borneolum Syntheticum fine powder, mixing, 70 ℃ of insulations splash into it in 0 ℃ the liquid paraffin condensed fluid with homemade drop pill machine, condensation is shrunk to ball, wash ball with liquid paraffin, wipe the liquid paraffin on drop pill surface then away, select ball, packing after the assay was approved, promptly.
Claims (6)
1, a kind ofly is used for the treatment of the anginal drop pill that coronary heart disease causes, it is characterized in that it is made up of Chinese medicine extract that contains effective composition and substrate.
2, a kind of anginal drop pill that coronary heart disease causes that is used for the treatment of as claimed in claim 1 is characterized in that containing the Chinese medicine extract of effective composition and the weight ratio of substrate is 1: 1～2: 9.
3, as claim 1 and 2 described a kind of anginal drop pills that coronary heart disease causes that are used for the treatment of, it is characterized in that substrate is Polyethylene Glycol; Can be that molecular weight polyethylene glycol is any substrate of any one or two kinds of above mixture in 4000～10000.
4, a kind of anginal drop pill that coronary heart disease causes that is used for the treatment of as claimed in claim 1, the Chinese medicine extract that it is characterized in that containing effective composition extracts processing by following Chinese medicine raw materials by weight proportion and gets:
2～15 parts of 9～36 parts of Rhizoma Chuanxiongs of 6～15 parts of Radix Puerariaes of 2～12 parts of Radix Salviae Miltiorrhizaes of the Radix Astragali
2～15 parts of 6～22 parts of Radixs Angelicae Dahuricae of 1～12 part of Rhizoma Corydalis of 4～27 portions of Radix Notoginseng of Ramulus Cinnamomi
4～12 parts of 6～27 parts of Semen Myristicaes of 1～12 part of Rhizoma Pinelliae Preparatum of Borneolum Syntheticum,
5, as claim 1 and 4 described a kind of anginal drop pills that coronary heart disease causes that are used for the treatment of, it is characterized in that the optimum weight proportioning of each raw material of Chinese medicine component is:
6 parts of 27 parts of Rhizoma Chuanxiongs of 12 parts of Radix Puerariaes of 9 parts of Radix Salviae Miltiorrhizaes of the Radix Astragali
12 parts of 15 parts of Radixs Angelicae Dahuricae of 6 parts of Rhizoma Corydalis of 19 portions of Radix Notoginseng of Ramulus Cinnamomi
8 parts of 15 parts of Semen Myristicaes of 5 parts of Rhizoma Pinelliae Preparatum of Borneolum Syntheticum.
6, as the described a kind of anginal drop pill that coronary heart disease causes that is used for the treatment of of claim 1-5, it is characterized in that the preparation technology of this drop pill is:
(1) Borneolum Syntheticum is ground into fine powder, all the other each medicine pulverize separately become coarse powder, cross 10～50 mesh sieves, and are standby;
(2) take by weighing Rhizoma Chuanxiong, Ramulus Cinnamomi, Semen Myristicae by formula proportion, mix, extract volatile oil with steam distillation, collect volatile oil, medicinal residues and water liquid are standby;
(3) get Radix Salviae Miltiorrhizae, Rhizoma Corydalis, the Radix Angelicae Dahuricae, mix, add 60～80% alcohol heating reflux and extract three times, extracted respectively 2,1,1 hours, merge alcohol extract (medicinal residues are standby), filter, decompression filtrate recycling ethanol also is condensed into clear paste, alcohol-extracted extract is standby;
(4) all the other Radixs Astragali, Radix Puerariae etc. four flavor coarse powder mix in the side of getting, decoct with water 3 hours after, add medicinal residues after the alcohol extraction of the medicinal residues of (2) and water liquid and (3), fried in shallow oil altogether again 2 hours, put cold filtration, filtrate is concentrated into the clear paste that relative density is 1.12～1.18 (60 ℃), and is standby;
(5) get (3) alcohol-extracted extract that makes and clear paste that (4) make, mix,, pulverize the powder that gets dry extract in 70 ℃ of drying under reduced pressure, standby;
(6) in proportion, dried cream powder is added in the single or mixed-matrix of fused Polyethylene Glycol, stir and make its dissolving or suspendible, add volatile oil and Borneolum Syntheticum fine powder, mixing, 40～70 ℃ of insulations splash into it in 0～10 ℃ the liquid paraffin condensed fluid with self-control or general drop pill machine, condensation is shrunk to ball, wash ball with liquid paraffin, wipe the liquid paraffin on drop pill surface then away, select ball, packing after the assay was approved, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101190775A CN101342346A (en) | 2008-08-28 | 2008-08-28 | Drop pill for treating stenocardia caused by coronary disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101190775A CN101342346A (en) | 2008-08-28 | 2008-08-28 | Drop pill for treating stenocardia caused by coronary disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101342346A true CN101342346A (en) | 2009-01-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2008101190775A Pending CN101342346A (en) | 2008-08-28 | 2008-08-28 | Drop pill for treating stenocardia caused by coronary disease |
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| CN (1) | CN101342346A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104352854A (en) * | 2014-11-04 | 2015-02-18 | 赵国忠 | Angina pectoris Yang activating, blood circulation promoting and stasis removing preparation and preparation method thereof |
| CN109260260A (en) * | 2018-11-21 | 2019-01-25 | 青海晶珠藏药高新技术产业股份有限公司 | It is a kind of to treat treating coronary heart disease and angina pectoris and preparation method thereof |
| CN113116998A (en) * | 2021-05-19 | 2021-07-16 | 张学雷 | Special-effect pill for treating pain and preparation method thereof |
-
2008
- 2008-08-28 CN CNA2008101190775A patent/CN101342346A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104352854A (en) * | 2014-11-04 | 2015-02-18 | 赵国忠 | Angina pectoris Yang activating, blood circulation promoting and stasis removing preparation and preparation method thereof |
| CN109260260A (en) * | 2018-11-21 | 2019-01-25 | 青海晶珠藏药高新技术产业股份有限公司 | It is a kind of to treat treating coronary heart disease and angina pectoris and preparation method thereof |
| CN113116998A (en) * | 2021-05-19 | 2021-07-16 | 张学雷 | Special-effect pill for treating pain and preparation method thereof |
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Open date: 20090114 |