CN114767794B

CN114767794B - Traditional Chinese medicine for treating arterial plaque

Info

Publication number: CN114767794B
Application number: CN202210484683.7A
Authority: CN
Inventors: 孙予杰; 张涛; 张振强; 王海超
Original assignee: Hainan Wandailan Biomedical Technology Co ltd
Current assignee: Hainan Wandailan Biomedical Technology Co ltd
Priority date: 2022-05-06
Filing date: 2022-05-06
Publication date: 2023-07-25
Anticipated expiration: 2042-05-06
Also published as: CN114767794A

Abstract

A traditional Chinese medicine for treating arterial plaque is prepared from the following raw materials in parts by weight: 2-8g of ginseng, 2-8g of astragalus, 2-8g of Chinese yam, 5-15g of garlic, 2-8g of pseudo-ginseng, 2-8g of hawthorn, 2-5g of Ningpo Yam rhizome, 2-8g of limonium, 5-15g of rice bran, 1-2g of pedicellus melo, 5-15g of spina gleditsiae and 2-8g of lily; mixing the processed ginseng and the pseudo-ginseng together, adding water which is 5-10 times of the total weight of the raw materials, boiling for 15-20min, adding the processed astragalus, the yam, the garlic, the hawthorn, the Ningpo Yam rhizome, the limonium, the rice bran, the pedicellus melo, the spina gleditsiae and the lily, decocting for 1-2 h to obtain a first decoction, adding water which is 4-8 times of the total weight of the raw materials into the residues, decocting for 1-2 h to obtain a second decoction, combining the two decoctions, and filtering to obtain the Chinese medicinal composition. The medicine has scientific and reasonable compatibility and simple preparation method, can effectively treat arterial plaque by strengthening spleen and stomach, tonifying qi and warming yang, activating blood and dissolving stasis, and resolving phlegm and reducing turbidity, and has remarkable social and economic benefits.

Description

Traditional Chinese medicine for treating arterial plaque

Technical Field

The invention relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine for treating arterial plaque, which is taken by patients with arterial plaque.

Background

Vascular plaque is one of the common causes of cardiovascular and cerebrovascular diseases, and is mainly characterized by the formation of fibrous plaque from the intima of blood vessels, deposited in large and medium arteries, and causes stiffening of the vessel wall, lumen thinning and weakening of the elasticity of the vessel wall, thereby causing ischemia of the corresponding organs.

The increased cholesterol deposits on the intima of the artery, causing connective tissue to proliferate, thickening and stiffening the arterial wall, which in turn necroses to form atheromatous plaques. Various stimuli can cause different degrees of damage to endothelial cell structure and function, which can cause excessive deposition of plasma components such as lipoproteins in intima, and at the same time cause platelet adhesion, aggregation and release of various active substances, thereby causing vascular plaque.

Vascular plaque typically occurs in the large, middle and peripheral arteries of the whole body, including the aorta, carotid and limb arteries, visceral arteries, and the like. In general, carotid vascular plaque is more common and easier to find. Carotid artery is the most important cerebral blood supply artery, arterial plaque is one of the most common causes of cardiovascular and cerebrovascular diseases, and is mainly characterized in that vascular intima forms fibrous plaque which is deposited on large and medium arteries to harden the wall of the blood vessel, thin the lumen and weaken the wall elasticity, and once plaque falls off, acute cerebral infarction, acute myocardial infarction, pulmonary embolism, sudden death and other diseases can be caused. The formation cause is mainly that the 'bad cholesterol' in human blood is increased to stimulate angiogenesis and inflammation and damage the vessel wall, thereby being more beneficial to the aggregation of cholesterol and forming large and unstable plaque. Many patients with carotid sclerosis do not have any neurological symptoms clinically or only have some nonspecific manifestations such as dizziness, transitional amaurosis, headache, syncope, etc., carotid plaque breaks or directly blocks the lumen, affecting the blood supply to the brain, thus causing acute cerebral infarction, which can be disabling or fatal. Coronary artery plaque can often cause angina pectoris, and myocardial infarction can occur after ruptured hemorrhage. Vascular plaques can also occur in the lower extremities, which can cause limb ischemia and movement impairment.

The theory of traditional Chinese medicine holds that the people with vascular plaques such as carotid plaque and the like often have factors of lung-spleen qi deficiency, heart-yang deficiency, liver-kidney deficiency, qi stagnation and blood stasis and other viscera dysfunction; plaque is formed by external factors such as overstrain, trauma, pathogenic qi due to wind-cold-dampness, deficiency of qi and blood due to internal factors, internal injury due to seven emotions, or the elderly and weak, and is caused by qi stagnation and blood stasis, and phlegm stagnation and blood stasis. Or the heart yang failing to circulate and stop in the pulse, stagnant blood and turbid phlegm accumulating in the pulse. It is usually associated with excessive pathogenic qi due to phlegm-dampness or qi stagnation and blood stasis. The formation of phlegm-dampness and blood stasis is closely related to the three viscera of heart, liver and spleen. The heart governs blood vessels, and the heart yang is sufficient to promote qi and blood circulation, so that the blood vessels are smooth; liver governs smoothing flow of qi, and qi stagnation occurs if there is a problem; spleen and stomach govern transportation and transformation, spleen and stomach are not healthy and transportation, and stomach and intestine are prone to phlegm-dampness, leading to stagnation of phlegm-dampness in the collaterals. The traditional Chinese medicine has the characteristics of good curative effect, small toxic and side effects and the like in the aspect of treating vascular plaques, but has not been reported publicly so far.

Disclosure of Invention

Aiming at the situation, the invention aims to overcome the defects of the prior art and provide the traditional Chinese medicine for treating the arterial plaque, which can effectively solve the problem that the traditional medicine can not treat the arterial plaque well.

In order to achieve the aim, the technical scheme of the invention is that the traditional Chinese medicine for treating arterial plaque is prepared from the following raw materials in parts by weight: 2-8g of ginseng, 2-8g of astragalus, 2-8g of Chinese yam, 5-15g of garlic, 2-8g of pseudo-ginseng, 2-8g of hawthorn, 2-5g of Ningpo Yam rhizome, 2-8g of limonium, 5-15g of rice bran, 1-2g of pedicellus melo, 5-15g of spina gleditsiae and 2-8g of lily;

wherein, (1) processing: directly sun-drying radix Ginseng minus root hair; the astragalus root is prepared by diluting the honey with boiled water, adding the astragalus root slices, stirring the mixture uniformly, putting the mixture into a pot, adding the mixture into the pot with slow fire, frying the mixture until the mixture is deep yellow and does not stick hands, taking the mixture out and cooling the mixture; soaking rhizoma Dioscoreae in the solution of the above materials for 3-4 times, taking out, moistening, slicing, and drying in time; airing the garlic after harvesting at a ventilation position until the outer skin is dried; taking the pseudo-ginseng, removing impurities, cleaning, sprinkling water, moistening, slicing, and drying; preparing fructus crataegi with brown sugar, dissolving brown sugar in boiled water, filtering, heating residue in iron pan to boil, adding fructus crataegi, parching with slow fire until it is not sticky, removing the residue, and air drying; peeling rhizoma Dioscoreae Nipponicae and root and whisker, cutting, sun drying or oven drying; slicing Limonium sinense; rice Pi Kangbu bales; drying pedicellus melo in the clitoris to remove ash; removing impurities from fructus Gleditsiae Abnormalis, soaking without slicing, drying, and sieving to remove dust; removing impurities and oil leaves from raw materials;

(2) Decocting: mixing the processed ginseng and the pseudo-ginseng together, adding water which is 5-10 times of the total weight of the raw materials, boiling for 15-20min, adding the processed astragalus, the yam, the garlic, the hawthorn, the Ningpo Yam rhizome, the limonium, the rice bran, the pedicellus melo, the spina gleditsiae and the lily, decocting for 1-2 h to obtain a first decoction, adding water which is 4-8 times of the total weight of the raw materials into the residues, decocting for 1-2 h to obtain a second decoction, combining the two decoctions, and filtering to obtain the Chinese medicinal composition.

The medicine disclosed by the invention is scientific and reasonable in compatibility, simple in preparation method, and capable of effectively treating arterial plaque by strengthening spleen and stomach, tonifying qi and warming yang, promoting blood circulation and removing blood stasis, reducing phlegm and lowering turbidity through reasonable Chinese medicine types and mass ratios, and is a great innovation in medicines for treating arterial plaque, and remarkable social and economic benefits are achieved.

Detailed Description

The following describes specific embodiments of the present invention in detail with reference to examples and specific cases.

Example 1

A traditional Chinese medicine for treating arterial plaque is prepared from the following raw materials in parts by weight: 8g of ginseng, 8g of astragalus, 8g of Chinese yam, 15g of garlic, 8g of pseudo-ginseng, 8g of hawthorn, 5g of Ningpo Yam rhizome, 8g of limonium, 15g of rice bran, 2g of pedicellus melo, 15g of spina gleditsiae and 8g of lily; mixing the processed ginseng and the pseudo-ginseng together, adding water which is 10 times of the total weight of the raw materials, boiling for 20min, adding the processed astragalus, the yam, the garlic, the hawthorn, the Ningpo Yam rhizome, the Limonium sinense, the rice bran, the pedicellus melo, the spina gleditsiae and the lily, decocting for 2h to obtain a first decoction, adding water which is 8 times of the total weight of the raw materials into the residues, decocting for 2h to obtain a second decoction, combining the two decoctions, and filtering to obtain the Chinese medicinal composition.

Example 2

A traditional Chinese medicine for treating arterial plaque is prepared from the following raw materials in parts by weight: 3g of ginseng, 4g of astragalus, 3g of Chinese yam, 6g of garlic, 3g of pseudo-ginseng, 3g of hawthorn, 2g of Ningpo Yam rhizome, 3g of limonium, 6g of rice bran, 1g of pedicellus melo, 6g of spina gleditsiae and 3g of lily; mixing processed Ginseng radix and Notoginseng radix together, adding water 5 times of the total weight of the raw materials, boiling for 15min, adding processed radix astragali, rhizoma Dioscoreae, bulbus Allii, fructus crataegi, rhizoma Dioscoreae Nipponicae, limonium sinense, testa oryzae, pedicellus melo, spina Gleditsiae and Bulbus Lilii, decocting for 1 hr to obtain a first decoction, adding water 5 times of the total weight of the raw materials into the residue, decocting for 1 hr to obtain a second decoction, mixing the decoctions, and filtering.

Example 3

A traditional Chinese medicine for treating arterial plaque is prepared from the following raw materials in parts by weight: 5g of ginseng, 5g of astragalus, 5g of Chinese yam, 10g of garlic, 5g of pseudo-ginseng, 5g of hawthorn, 3g of Ningpo Yam rhizome, 5g of limonium, 10g of rice bran, 1.5g of pedicellus melo, 10g of spina gleditsiae and 5g of lily; mixing the processed ginseng and the pseudo-ginseng together, adding water which is 8 times of the total weight of the raw materials, boiling for 17min, adding the processed astragalus, the yam, the garlic, the hawthorn, the Ningpo Yam rhizome, the Limonium sinense, the rice bran, the pedicellus melo, the spina gleditsiae and the lily, decocting for 1.5h to obtain a first decoction, adding water which is 6 times of the total weight of the raw materials into the residues, decocting for 1.5h to obtain a second decoction, combining the two decoctions, and filtering to obtain the Chinese medicinal composition.

Example 4

A traditional Chinese medicine for treating arterial plaque is prepared from the following raw materials in parts by weight: 8g of ginseng, 8g of astragalus, 6g of Chinese yam, 12g of garlic, 6g of pseudo-ginseng, 6g of hawthorn, 5g of Ningpo Yam rhizome, 8g of limonium, 15g of rice bran, 1g of pedicellus melo, 12g of spina gleditsiae and 6g of lily; mixing processed Ginseng radix and Notoginseng radix together, adding water 9 times of the total weight of the raw materials, boiling for 18min, adding processed radix astragali, rhizoma Dioscoreae, bulbus Allii, fructus crataegi, rhizoma Dioscoreae Nipponicae, limonium sinense, testa oryzae, pedicellus melo, spina Gleditsiae and Bulbus Lilii, decocting for 2 hr to obtain a first decoction, adding water 7 times of the total weight of the raw materials into the residue, decocting for 2 hr to obtain a second decoction, mixing the decoctions, and filtering.

The raw material medicine of the invention, wherein, the ginseng is sun-dried, and the ginseng minus root must be directly sun-dried; the astragalus root is prepared by diluting the honey with boiled water, adding the astragalus root slices, stirring the mixture uniformly, putting the mixture into a pot, adding the mixture into the pot with slow fire, frying the mixture until the mixture is deep yellow and does not stick hands, taking the mixture out and cooling the mixture; soaking rhizoma Dioscoreae in the solution of the above materials for 3-4 times, taking out, moistening, slicing, and drying in time; airing the garlic after harvesting at a ventilation position until the outer skin is dried; preparing fructus crataegi with brown sugar, dissolving brown sugar in boiled water, filtering, heating residue in iron pan to boil, adding fructus crataegi, parching with slow fire until it is not sticky, removing the residue, and air drying; taking the pseudo-ginseng, removing impurities, cleaning, sprinkling water, moistening, slicing, and drying; peeling rhizoma Dioscoreae Nipponicae and root and whisker, cutting, sun drying or oven drying; slicing Limonium sinense; rice Pi Kangbu bales; removing impurities and oil leaves from raw materials; drying pedicellus melo in the clitoris to remove ash; the Chinese honeylocust spine is prepared by removing impurities from crude medicinal materials, soaking without slicing, slicing into thick slices, drying, and sieving to remove dust.

In the above-mentioned medicine, the medicine,

ginseng: sex taste: sweet, slightly bitter and warm, has the effects of tonifying qi, relieving depletion, tonifying lung, tonifying spleen, promoting salivation, soothing nerves and improving intelligence, is used for treating the functions of tonifying qi, relieving depletion, tonifying heart, restoring pulse, soothing nerves, promoting salivation, tonifying lung, strengthening spleen and the like, and has good curative effects on cardiovascular diseases, stomach and liver diseases, diabetes, different types of neurasthenia, various psychoses, impotence, certain cancers and the like.

Radix astragali: sex taste: sweet and slightly warm, has effects of invigorating qi, consolidating superficial resistance, promoting urination, removing toxic substances, promoting pus discharge, and promoting granulation, and can be used for treating qi deficiency debilitation, anorexia, loose stool, sinking of middle-jiao, chronic diarrhea rectocele, hematochezia metrorrhagia, spontaneous perspiration due to exterior deficiency, qi deficiency edema, carbuncle, difficult ulcer, chronic ulcer, blood deficiency flaccidity yellow, internal heat diabetes, chronic nephritis proteinuria, diabetes, etc.

Chinese yam: the dioscin in the yam is called natural hormone mother, can promote synthesis of endocrine hormone, enhance metabolism of skin epidermal cells and skin moisturizing function, and improve physique. The Chinese yam is beneficial to enhancing the digestion and absorption functions of the spleen and the stomach, and is a medicine and food dual-purpose product for balancing and tonifying the spleen and the stomach. It can be eaten regardless of spleen-yang deficiency or stomach-yin deficiency. It is often combined with gastrointestinal fluids in clinic to treat spleen and stomach weakness, anorexia, tiredness, diarrhea, etc. Rhizoma Dioscoreae has effects of strengthening body constitution, nourishing kidney and replenishing vital essence. It is indicated for seminal emission due to kidney deficiency, leukorrhagia and frequent urination.

Garlic: allicin can regulate lipid metabolism membrane transport and cell proliferation by increasing liver cyclic adenylate level, and increase enzyme activity, increase blood lipid hydrolysis, reduce biosynthesis, increase excretion of blood lipid component, and maintain serum, liver and kidney lipoproteins and triglycerides in normal range, thereby preventing and treating fatty liver.

Allicin can prevent and treat cardiovascular and cerebrovascular diseases, arrhythmia, protect cardiac muscle, and treat cerebral ischemia. According to research, allicin is used for inhibiting Ca < 2+ > overload in human atrial myocytes through the antioxidant activity of the allicin, and preventing and treating atrial fibrillation. Allicin has better therapeutic effect on ischemic heart disease, has strong anti-free radical activity, and is one of mechanisms of anti-myocardial cell injury of allicin. It is also believed that the mechanism of action of allicin against myocardial ischemia/reperfusion injury may be related to anti-myocardial apoptosis. The therapeutic action mechanism of allicin on ischemic cerebrovascular disease is closely related to free radical scavenging and nitric oxide level increasing besides dilating blood vessel, increasing cerebral blood flow, reducing blood plasma endothelin and inhibiting platelet aggregation.

Pseudo-ginseng: warm nature and sweet taste. Has hemostatic, blood stasis dispelling, repercussive, and analgesic effects.

Hawthorn fruit: fructus crataegi is rich in vitamin C, carbohydrate, various minerals, carotene, etc., and has effects of invigorating stomach, resolving food stagnation, activating qi-flowing, dispelling blood stasis, eliminating turbid pathogen, and reducing blood lipid. The parched or carbonized fructus crataegi has effects of invigorating stomach and resolving food stagnation. All symptoms such as blood stasis, amenorrhea, dysmenorrhea, postpartum blood stasis and the like can also be treated by the hawthorn, and the hawthorn has the effects of promoting qi circulation and removing blood stasis. Hawthorn fruit can treat thorn pain in heart and abdomen, obstruction of qi in the chest, pain in heart, hernia pain and the like and has the effects of eliminating turbid pathogen and reducing blood fat.

Ningpo Yam rhizome: bitter in property and flat. It enters liver and lung meridians. Pharmacological study:

1, the Ningpo Yam rhizome has the effects of resisting inflammation and easing pain. The Fujian Ningpo Yam rhizome can obviously inhibit mouse auricular inflammation caused by dimethylbenzene, and rat carrageenan foot joint swelling, reduce capillary permeability of the abdominal cavity of the mouse and obviously inhibit rat cotton ball granuloma; the pain response time of the mice can be prolonged, and the torsion response times of the mice can be reduced;

2. has cardiovascular effect and can reduce blood cholesterol level. The total saponin 10 mg/kg can reduce the cholesterol level of rabbit blood from 29.04 mmol/L to 8.06-8.32 mmol/L, can slow down heart rate, enhance myocardial contractility, increase daily urine volume, reduce the ratio of B/a lipoprotein, improve coronary circulation, reduce arterial blood pressure, and is especially suitable for light and medium atherosclerosis. Can remarkably increase the myocardial nutritional blood flow;

3. can affect immune function. The mice are fed with yam decoction 15g (crude drug)/kg daily for 7 days, thymus atrophy is caused, the positive rate of peripheral blood lymphocytes a-acetic acid tea esterase (ANAE) is reduced, skin delayed hypersensitivity caused by Dinitrochlorobenzene (DNCB) is inhibited, the formation of serum hemolysin is reduced, the percentage and phagocytic index of the abdominal macrophages phagocytosed chicken erythrocytes are increased, and the content of serum lysozyme is increased. The Ningpo Yam rhizome water decoction alcohol extractant is administrated in vitro, so that the proliferation reaction of spleen cells induced by ConA can be inhibited, and the inhibition can only occur when a human medicine is added in the early stage of culture. l g/kg of Ningpo Yam rhizome total saponins can obviously reduce erythrocyte hemolysin antibody generation of mice and sheep and delayed type hypersensitivity caused by dinitrofluorobenzene by gastric lavage administration.

In addition, the Ningpo Yam rhizome decoction has obvious anti-influenza virus effect and has obvious inhibition effect on staphylococcus aureus, sarcina, catarrhalis, meningococci, streptococcus A and the like.

Limonium sinense (L.) kuntze: it is sweet and flat in nature and nontoxic. The main ingredients comprise various flavonoids including Myricaria rubra bark martial arts (Myricetrin), myricaria rubra, myricetin rhamnose glucose martial arts (Myricaria rubra), myricetin, isorhamnetin, quercetin, myricetin methyl ether, and tetrahydroxy flavone. Further contains anthocyanidin condensed tannin, which comprises anthocyanidin (Cyanidol) and its rhamnose type delphinidin (Delphi-nidol). Clinically, it can stop bleeding and dispel blood stasis. (Xinjiang Manual of Chinese herbal medicine: bleeding stopping and stasis removing, treating functional bleeding, cervical cancer and other bleeding).

Rice Pi Kang: sweet, pungent, flat and nontoxic, and enters the hand and foot yangming meridians. Pharmacological research shows that the sitosterol contained in rice bran can act on hypothalamus and cerebral limbic system to improve autonomic nerve dysfunction. Experiments prove that the composition can promote the growth of rats and increase the content of glycogen in livers. An anticancer substance is extracted from caulis oryzae, husk or bran, and is effective on ascites carcinoma and sarcoma-180 of transplanted mice.

Pedicellus melo: bitter in flavor, cold in nature and toxic. Enter spleen and stomach meridians. The functions are mainly: wind-phlegm retention in food and water-damp retention. For epilepsy and mania due to phlegm-heat stagnation in chest, manifested as sore throat and wheezing due to phlegm-stagnation in throat, it can be indicated for dysphoria and insomnia, or distending pain in chest and abdomen due to food retention in stomach.

Spina gleditsiae: pungent and warm in property. It enters liver, lung and stomach meridians. The clinical functions are mainly used for detumescence, pus expelling, wind expelling and insect killing. It is mainly used for treating carbuncle, cellulitis, toxic swelling, tuberculosis, sore, rash, stubborn tinea, postpartum hypogalactia, and retained fetal membranes. Spina Gleditsiae can induce resuscitation and induce phlegm, and its property is Xin Sheng, and it can induce into the channels of jueyin, shaoyin, taiyin and yangming. (Yang Shiying) can direct the upward movement of all herbs to treat upper energizer disease (from the outline of the invention).

Lily: can clear heart and relieve restlessness, calm heart and calm mind, and can be used for treating absentmindedness, insomnia and dreaminess, mood depression, etc.

The invention takes ginseng, astragalus and yam as principal drugs for tonifying qi and nourishing yin, and garlic, hawthorn, pseudo-ginseng, ningpo Yam rhizome, limonium sinense and rice bran as ministerial drugs for activating blood and nourishing blood, and resolving phlegm and removing turbidity; lily nourish yin, moisten lung and dispel phlegm, melon pedicel, purge heart fire and invigorate spleen soil are used as adjuvant drugs, spina gleditsiae can induce resuscitation and remove phlegm, and the large Xin Sheng powder can be introduced into jueyin, shaoyin, taiyin and yangming meridians as guiding drugs. The medicines monarch, minister, assistant and guide are scientifically and reasonably prepared, mutually supported and matched, and the side effects on the body are reduced while the curative effect of the medicines is exerted.

From the above, the invention adopts different processing methods aiming at the nature, taste and meridian tropism of different medicinal materials, fully plays the toxic and side effects of the effective components of the medicaments to remove the medicaments, has good curative effect through clinical experiments, and takes example 3 as an example, and the clinical data are as follows:

1. case selection

1. Case enrollment criteria:

(1) Has diabetes. The incidence of diabetic patients is several times higher than non-diabetic patients, and lesions progress rapidly. The blood lipid level of the diabetics is obviously increased, and the hyperglycemia can cause lipid peroxidation, so that blood mononuclear cells are promoted to migrate into an inner membrane and be converted into foam cells;

(2) Dyslipidemia. Lipid metabolism abnormalities are the most important risk factor for arterial plaque formation and are often manifested as hypercholesterolemia. When hyperlipidemia, the low density lipoprotein is oxidized and modified by arterial wall cells, and has the effect of promoting formation of atheromatous plaque;

(3) Hypertension. The incidence of atherosclerosis and plaque formation in patients with hypertension is markedly increased. The mechanical pressure and impact of blood flow on the vascular wall during hypertension cause damage to vascular endothelium, so that the permeability of the intima to lipid is increased, and the lipid protein is easy to infiltrate into the intima, thereby promoting the occurrence of vascular plaque;

the symptoms (1), (2) and (3) are adopted, and when the heart color Doppler ultrasound and the carotid color Doppler ultrasound are checked to find that the inner wall and the pipe diameter of the blood vessel are abnormal, the symptoms are used as the objects of the selected cases;

2. 100 patients diagnosed with arterial plaque formation and informed consent were selected for this observation of efficacy, of which male and female were 37; 56 cases over 60 years of age, 44 cases under 60 years of age, with the largest 82 years of age and the smallest 36 years of age. The control group comprises 74 cases, 48 cases for men and 26 cases for women, and the ages of 42-80 years, and the difference between the two groups in terms of illness state, sex, age, illness course and the like through statistical treatment has no statistical significance.

2. Treatment regimen

Control group: besides the conventional medicines for treating basic diseases, the medicine is taken: rosuvastatin calcium tablet is 10mg each time, 1 time a day, and aspirin (bayer aspirin) 100mg, 1 time a day, 30 days as a course of treatment, 3 courses of treatment;

treatment group: the traditional Chinese medicine decoction is taken twice a day in the morning and evening according to the processing and manufacturing method, and the dosage is 200-300 ml/time and is taken warm. 30 days is a treatment course, and the medicine is taken for 3 treatment courses.

Wherein, the control group and the treatment group can not eat low-salt, low-fat and low-sugar diet such as cold, slimy, sweet, five-spice, tobacco and wine during the period of taking medicine.

3. Efficacy assessment criteria

Reference to the standard of "Chinese medicine New medicine clinical study guidelines" and "diagnostic curative effect Standard of Chinese medical Condition", and check by heart color Doppler ultrasound and carotid color Doppler ultrasound:

and (3) curing: plaque disappeared;

the effect is shown: the thickness and the area of the plate are obviously reduced;

the method is effective: plaque thickness and area are unchanged;

invalidation: the plaque thickness and area increase are all more than or equal to 0.2 mm.

4. Statistical treatment

The curative effect results show that of 100 patients in the treatment group, 55 patients are cured, 23 patients are effective, 14 patients are effective, and 8 patients are ineffective. The total effective rate reaches 92%; of 74 patients in the control group, 12 patients are cured, 24 patients are effective, 18 patients are effective, 20 patients are ineffective, and the total effective rate is 72.97%. The difference in the effective rates of the two groups is statistically significant, and the treatment group is significantly better than the control group, as shown in Table 1.

Table 1: comparison of the therapeutic Effect of two groups of patients

Group of	Number of examples	Healing	Has obvious effect	Effective and effective	Invalidation of	Total effective rate
							Treatment group	100	55	23	14	8	92%
Control group	74	12	24	18	20	72.97%

5. Typical cases

Case one: liu Mou Male, 75 years old, dry part. First diagnosis is made at 20 days 7 and 2021. The main complaints are chest distress, asthma and hypodynamia. The weight is increased after the movement. The patient is hospitalized with chest distress and chest pain in a local hospital at day 29 of 6 months 2021, and heart color Doppler ultrasound prompts when hospitalized: 1. left heart is large; 2. mitral (middle) tricuspid valve (light) regurgitation; 3. left ventricular systolic and diastolic dysfunction; 4. left ventricular wall staged motion abnormality; 5. arterial plaque formation. Carotid color ultrasound suggests left carotid plaque formation: 7.6X1.8mm, plaque formation in the posterior and anterior wall of the right common carotid sinus: 5.8x1.7mm, 12x2.9mm. Doctor orders the heart stent operation. Patients do not want to be treated by surgery and are treated by traditional Chinese medicine in the future after discharge from hospital. Chest distress and chest pain of patients are not healed for a long time, aggravated after being irritated and tired, and dyspnea is caused by more than ten steps of walking. A dark purple tongue with ecchymosis, little coating and a wiry and astringent pulse. The disease is considered to be phlegm stasis obstruction caused by the old and weak, the cold evil attack, the emotional loss, the improper diet and the tiredness internal injury, and the blood vessel is reserved, which belongs to the category of chest stuffiness in traditional Chinese medicine. Western diagnosis: 1. arterial plaque formation; 2. left ventricular hypertrophy; 3. mitral valve, tricuspid valve insufficiency. The treatment is to take the method of warming yang, resolving turbidity, removing blood stasis and dredging collaterals, and re-diagnosing in the period of 10 months and 20 days of 2021 after taking for 3 months, so that the patient can obviously improve chest distress and asthma and want to engage in the prevention of the physical labor family. Review heart color ultrasound cues: 1. a reduced systolic and diastolic function of the left ventricle; secondly, the left chamber wall is abnormal in stepwise motion; 3. mitral valve mild regurgitation. Carotid color ultrasound prompting: carotid color ultrasound suggests left carotid plaque formation: 4.8x1.6mm, plaque formation in the posterior and anterior walls of the sinus of the right common carotid artery: 1.9x1.7mm, 10x1.8mm. Two controls: the heart function is improved, the large plaque is obviously smaller, and the effect is obvious.

Case two: zhao Mou male, 55 years old. Coronary CT results at the three-channel center hospital at 8 months 30 days 2020: 1. right crown dominance type; 2. left Anterior Descending (LAD) proximal plaque luminal stenosis about 70%; 3. left Anterior Descending (LAD) middle calcification plaque lumen is slightly stenosed; 4. the Right Crown (RCA) is 40-50% of the proximal and middle macula softening lumen stenosis. The traditional Chinese medicine decoction is taken according to the doctor's advice specification, and after one year of taking the decoction, coronary artery CT results are checked in the Sanmen Hospital of yellow river at 2021, 9 and 23 days: mild coronary atherosclerosis, left Anterior Descending (LAD) proximal non-calcified plaque with lumen stenosis, middle and distal vessel wall finishing, right Coronary (RCA) vessel wall finishing, and no stenosis in lumen. Comparison of results: the proximal soft spots of the Left Anterior Descending (LAD) are obviously reduced, the lumen stenosis is reduced by 10-20% from 70%, the middle hard spots of the Left Anterior Descending (LAD) and the proximal soft spots of the Right Crown (RCA) disappear, and the lumen is not narrowed. Results: the basic cure is realized.

Case three: record something, female, 62 years old. The physician can visit the department of neurology in the province of three months at the month of 2020, and the color ultrasound on the neck prompts the mixed echo plaque of the common carotid artery with the size of about 5x1.6mm. The traditional Chinese medicine decoction is taken according to the doctor's advice specification, and after one year of taking, the cervical blood vessel color ultrasound prompt double-sided common carotid artery intima-media thickening and roughness are reviewed in Zhengzhou Wuzhou Hospital at 2021, 10 months and 14 days. Comparison of results before and after treatment: the soft spots disappeared. Results: curing.

Case four: han Mou Male, 62 years old, dry part. First diagnosis in third people's hospitals in Zhengzhou city at 1 month 19 days 2022 shows that the carotid color ultrasound shows that the left common carotid artery can see multiple plaque echoes, the larger plaque is a mixed plaque, and the plaque is positioned on the rear wall of the bifurcation part, and is about 10x2mm; the right common carotid artery sees multiple plaque echoes, the larger of which is a mixed plaque, located at the anterior wall of the bifurcation, approximately 20x9mm; prompting: bilateral carotid, vertebral, and subclavian intima-media localized thickening and multiple plaque formation. The traditional Chinese medicine decoction taking the prescription of the example 5 according to the doctor's advice criterion is taken for almost two months, and after 2022, 3 and 15 days, the color ultrasonic review of the third people hospital in Zhengzhou city is as follows: the left common carotid artery sees multiple plaque echoes, the larger of which is a mixed plaque, located at the posterior wall of the bifurcation, approximately 7x1.7mm; the right common carotid artery sees multiple plaque echoes, the larger of which is a mixed plaque, located at the anterior wall of the bifurcation, approximately 3x2.1mm; prompting: bilateral carotid arteries, vertebral arteries, subclavian intima-media thickening and multiple plaque formation. Comparison before and after administration: plaque is significantly reduced. Conclusion: has obvious effect.

Meanwhile, the experiment is carried out on the embodiment 3, and the same experiment is carried out on the embodiments 1, 2, 4 and 5, and the results which are the same as or similar to the embodiment 3 are obtained after the statistical treatment, so that the effects of the invention are stable and reliable, and are not listed here.

6. Conclusion:

in conclusion, the treatment effect of the traditional Chinese medicine decoction prepared by taking the traditional Chinese medicine decoction is obviously superior to the combined use of statin lipid-lowering drugs and antiplatelet drugs in treatment, and no adverse reaction is found in the pure traditional Chinese medicine preparation. The invention has scientific and reasonable formula, aims at the etiology of arterial plaque formation, mainly eliminates plaque, reduces cholesterol and low-density cholesterol, increases vascular permeability, eliminates substances harmful to heart and cerebral vessels, protects the health of heart and cerebral vessels, and takes the effects of activating blood circulation to remove blood stasis, reducing blood fat to promote blood circulation and resolving phlegm to remove turbidity as the main part, scientifically and reasonably prepares medicines monarch, minister, assistant and guide, mutually supports each other, mutually cooperates, plays the curative effect of the medicines, reduces the side effect on the body, and returns to the meridian for the nature and the taste of different medicinal materials, adopts different processing methods, fully plays the roles of the effective components of the medicines, and has huge social and economic benefits.

It is to be noted that the technical characteristics and key of the present application are that the compatibility of the traditional Chinese medicine composition is that the decoction provided by the above is only an embodiment of a dosage form, and all the dosage forms which are made by adopting equivalent replacement means and are essentially the same as the present application or adopting the traditional Chinese medicine composition to prepare by adopting the conventional preparation method are suitable for taking, such as powder (powder), granules, pills, tablets, oral liquid, capsules and the like, and all the dosage forms belong to the protection scope of the present application.

Claims

1. The traditional Chinese medicine for treating arterial plaque is characterized by being prepared from the following raw materials in parts by weight: 2-8g of ginseng, 2-8g of astragalus, 2-8g of Chinese yam, 5-15g of garlic, 2-8g of pseudo-ginseng, 2-8g of hawthorn, 2-5g of Ningpo Yam rhizome, 2-8g of limonium, 5-15g of rice bran, 1-2g of pedicellus melo, 5-15g of spina gleditsiae and 2-8g of lily;

wherein, (1) processing: directly sun-drying radix Ginseng minus root hair; the astragalus root is prepared by diluting the honey with boiled water, adding the astragalus root slices, stirring the mixture uniformly, putting the mixture into a pot, adding the mixture into the pot with slow fire, frying the mixture until the mixture is deep yellow and does not stick hands, taking the mixture out and cooling the mixture; soaking rhizoma Dioscoreae in the solution of the above materials for 3-4 times, taking out, moistening, slicing, and drying in time; airing the garlic after harvesting at a ventilation position until the outer skin is dried; taking the pseudo-ginseng, removing impurities, cleaning, sprinkling water, moistening, slicing, and drying; preparing fructus crataegi with brown sugar, dissolving brown sugar in boiled water, filtering, heating residue in iron pan to boil, pouring clean fructus crataegi, parching with slow fire until it is not sticky, taking out, and air drying; peeling rhizoma Dioscoreae Nipponicae and root and whisker, cutting, sun drying or oven drying; slicing Limonium sinense; rice Pi Kangbu bales; drying pedicellus melo in the clitoris to remove ash; removing impurities from fructus Gleditsiae Abnormalis, soaking without slicing, drying, and sieving to remove dust; removing impurities and oil leaves from raw materials;

2. The traditional Chinese medicine for treating arterial plaque according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 8g of ginseng, 8g of astragalus, 8g of Chinese yam, 15g of garlic, 8g of pseudo-ginseng, 8g of hawthorn, 5g of Ningpo Yam rhizome, 8g of limonium, 15g of rice bran, 2g of pedicellus melo, 15g of spina gleditsiae and 8g of lily; mixing the processed ginseng and the pseudo-ginseng together, adding water which is 10 times of the total weight of the raw materials, boiling for 20min, adding the processed astragalus, the yam, the garlic, the hawthorn, the Ningpo Yam rhizome, the Limonium sinense, the rice bran, the pedicellus melo, the spina gleditsiae and the lily, decocting for 2h to obtain a first decoction, adding water which is 8 times of the total weight of the raw materials into the residues, decocting for 2h to obtain a second decoction, combining the two decoctions, and filtering to obtain the Chinese medicinal composition.

3. The traditional Chinese medicine for treating arterial plaque according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 3g of ginseng, 4g of astragalus, 3g of Chinese yam, 6g of garlic, 3g of pseudo-ginseng, 3g of hawthorn, 2g of Ningpo Yam rhizome, 3g of limonium, 6g of rice bran, 1g of pedicellus melo, 6g of spina gleditsiae and 3g of lily; mixing processed Ginseng radix and Notoginseng radix together, adding water 5 times of the total weight of the raw materials, boiling for 15min, adding processed radix astragali, rhizoma Dioscoreae, bulbus Allii, fructus crataegi, rhizoma Dioscoreae Nipponicae, limonium sinense, testa oryzae, pedicellus melo, spina Gleditsiae and Bulbus Lilii, decocting for 1 hr to obtain a first decoction, adding water 5 times of the total weight of the raw materials into the residue, decocting for 1 hr to obtain a second decoction, mixing the decoctions, and filtering.

4. The traditional Chinese medicine for treating arterial plaque according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 5g of ginseng, 5g of astragalus, 5g of Chinese yam, 10g of garlic, 5g of pseudo-ginseng, 5g of hawthorn, 3g of Ningpo Yam rhizome, 5g of limonium, 10g of rice bran, 1.5g of pedicellus melo, 10g of spina gleditsiae and 5g of lily; mixing the processed ginseng and the pseudo-ginseng together, adding water which is 8 times of the total weight of the raw materials, boiling for 17min, adding the processed astragalus, the yam, the garlic, the hawthorn, the Ningpo Yam rhizome, the Limonium sinense, the rice bran, the pedicellus melo, the spina gleditsiae and the lily, decocting for 1.5h to obtain a first decoction, adding water which is 6 times of the total weight of the raw materials into the residues, decocting for 1.5h to obtain a second decoction, combining the two decoctions, and filtering to obtain the Chinese medicinal composition.

5. The traditional Chinese medicine for treating arterial plaque according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 8g of ginseng, 8g of astragalus, 6g of Chinese yam, 12g of garlic, 6g of pseudo-ginseng, 6g of hawthorn, 5g of Ningpo Yam rhizome, 8g of limonium, 15g of rice bran, 1g of pedicellus melo, 12g of spina gleditsiae and 6g of lily; mixing processed Ginseng radix and Notoginseng radix together, adding water 9 times of the total weight of the raw materials, boiling for 18min, adding processed radix astragali, rhizoma Dioscoreae, bulbus Allii, fructus crataegi, rhizoma Dioscoreae Nipponicae, limonium sinense, testa oryzae, pedicellus melo, spina Gleditsiae and Bulbus Lilii, decocting for 2 hr to obtain a first decoction, adding water 7 times of the total weight of the raw materials into the residue, decocting for 2 hr to obtain a second decoction, mixing the decoctions, and filtering.