CN108159213A

CN108159213A - It is a kind of to be used to treat Chinese medicine composition of coronary heart disease and preparation method thereof

Info

Publication number: CN108159213A
Application number: CN201810258439.2A
Authority: CN
Inventors: 杨雷; 刘暖; 付卫云; 毛秉豫; 张千; 张千一; 刘萍; 赵威; 李星
Original assignee: Nanyang Institute of Technology
Current assignee: Nanyang Institute of Technology
Priority date: 2018-03-27
Filing date: 2018-03-27
Publication date: 2018-06-15

Abstract

The invention discloses a kind of for treating the Chinese medicine composition of coronary heart disease, the Chinese medicine composition includes the bulk pharmaceutical chemicals of following parts by weight：20~45 parts of Radix Astragali, 6~12 parts of cassia twig, 15~30 parts of hawthorn, 10~30 parts of Radix Salviae Miltiorrhizae, 15~40 parts of Caulis Spatholobi, 10~20 parts of rhizoma alismatis, 10~35 parts of Radix Angelicae Sinensis, 15~20 parts of dried orange peel, 15~20 parts of campanulaceae, 5~20 parts of oriental wormwood, 20~45 parts of kuh-seng, 3~15 parts of the coptis, 12~40 parts of spina date seed.Chinese medicine composition provided by the invention has effects that the tonifying Qi promoting flow of qi and blood circulation, the turbid dissipating phlegm and removing blood stasis of row, heat-clearing dredging collateral to stop pain, beneficial spleen cardiac stimulant are allayed excitement, and coagulates the scorching uneasy type patients with coronary heart disease of the simultaneous deficiency of blood suitable for treatment stagnation of the circulation of vital energy hemostasis phlegm.In clinical test, the traditional Chinese medicine composition for treating significant effect of present invention treatment coronary heart disease, total effective rate is up to 91%, and obvious effective rate is up to 71%.

Description

It is a kind of to be used to treat Chinese medicine composition of coronary heart disease and preparation method thereof

Technical field

The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of Chinese medicine composition and its system for being used to treat coronary heart disease Preparation Method.

Background technology

Coronary atherosclerotic heart disease be coronary atherosclerosis make lumen of vessels stenosis or occlusion or (and) because Coronary artery function, which sexually revises (spasm), to be caused caused by myocardial ischemia-anoxemia or necrosis with ictal chest pain or chest Discomfort is the clinical syndrome mainly showed, is common clinical, frequently-occurring disease.The disease mostly occurs in the crowd on 40 years old, male It is more using brain worker more than women, the incidence of the disease increases year by year, has become and endangers the invisible of human health and kill Hand.Therefore the comprehensive study to the disease to promoting the physical and mental health of the mankind, improves the quality of living, has great importance.

B.C. 11st century or so Cheng Shu's《The Classic of Mountains and Rivers》Middle discovery " pained " word,《The Classic of Mountains and Rivers Western Hills pass through》Day：" its Grass has Bi litchis, shape such as Stenoloma chusana, and is born on stone, also edge wood and give birth to, food it is pained.”《Mountain passes through in The Classic of Mountains and Rivers》Day：" and it is eastern In Nan Wushi, here the mountain before day is high has water thereon, very cold and clear, the slurry of Supreme Being's platform, and the person of drink is not pained ".This is probably the " heart The document of a word earliest extant bitterly " is recorded.《Ling Shu Miraculous Pivot or Divine Axis is fainted disease》Mention " angina pectoris, bluish colour of the limbs extending up to the elbows and knees, it is pained very, onset of disease in the morning and dying in the evening, Onset of disease in the evening and dying in the next morning ", " precordial pain with cold limbs, it is phased with carrying on the back, it is apt to Chi, if such as such as piercing the sleeping move house of its heart ... with awl bitterly from its rear tactile heart ..., Pained to ask, action pain benefit is very ".《Plain Questions numbness opinion》The concept of " obstruction of the heart qi " is referred to, " obstruction of the heart qi person, arteries and veins is obstructed, tired then severe palpitation, Cruelly upper gas and breathe heavily, choke is done kind, then fears on gas of fainting ".Coronary heart disease belongs to " obstruction of qi in the chest ", " pained ", " angina pectoris " in motherland's medicine Scope.Motherland's medicine thinks the formation of coronary heart disease and the factors such as physically weak overstrain, inernal injuries caused by seven emotions, being invaded by exogenous pathogen,invasion of exogenous pathogen, improper diet.Natural endowment Deficiency, ferritic is weak or prolonged illness is hindered just, and the sad gas of consumption is cloudy or the overstrain too impairment of the spleen, the source of vital function deficiency, negative and positive of qi and blood are deficient Weary, visceral dysfunction causes the mind to lose and supports,《Plain Questions numbness opinion》Have " arteries and veins person, the house of blood, hesitant pulse indicating precordial pain ".Feelings will is forfeited one's integrity, sorrow Anxiety impairs the spleen, dysfunction of the spleen, body fluid not cloth, and with gathering for phlegm, depressed rage impairing the liver, liver dysfunction, stagnation of QI due to depression of the liver, very then qi depression transforming into fire burn Tianjin is phlegm；" gas row then blood ", the stagnation of the circulation of vital energy or phlegm coagulate that blood can all be caused to be lost is smooth, and train of thought is unfavorable, and stagnation of QI-blood or phlegm-blood stasis is caused to hand over Resistance, chest sun are not transported, heart vessel blockage stasis, not general rule pain, and are sent out as the obstruction of qi in the chest.《Miscellaneous diseases source stream rhinoceros candlewick pathogeny stream》：" in a word seven feelings it It is pained by making ".Being invaded by exogenous pathogen,invasion of exogenous pathogen, " wet three gas of chill is miscellaneous extremely, combined into numbness.《Plain Questions numbness opinion》", with the passing of time, multiple sense is outer for rheumatism Heresy, interior house are obstructed, send out as the obstruction of qi in the chest in the heart, numbness resistance heart arteries and veins, painstaking effort operation.It is improper diet, such as overfeeding delicious food savoury or hobby tobacco and wine Habituation, so that taste are damaged, transporting loses strong, accumulatively wet raise phlegm, and upper criminal's bright and clean part in ambition checks heart-yang, hypofunction of YANG QI in chest, mechanism of qi is not Freely, heart vessel blockage stasis, into the obstruction of qi in the chest.The main pathogenesis of the obstruction of qi in the chest is heart vessel blockage stasis, and characteristic of disease belongs to this void table reality.Sick position in the heart, be related to liver, Spleen, kidney etc. are dirty.Its change of pathogenesis can sthenia symptoms caused by asthenia, also can because it is real cause it is empty.

Although western medicine and medical practitioners have more treatment coronary heart disease, antianginal drug, but it is taken for a long time, and patient can generate tolerance Property so that the effect of drug, is often unsatisfactory, and western medicine is usually by conjunctive uses such as lipid-lowering medicine, Thrombolytic Drugs, to reach drop The purpose of low platelet stickiness and coronary artery dilator, but it is palliative.And take Western medicine for a long time, it may appear that head The side effects such as dizzy, headache, palpitating speed, flushed face and hepar damnification, Toxicity of Kidney.For this purpose, it is good and malicious to find therapeutic effect The drug of Small side effects becomes the emphasis of field further investigation, and traditional Chinese medicine has significant superior in such disease is treated Property.With traditional Chinese medical science organic conception, diagnosis and treatment thinking, from entirety, adjustment body reaches " yin and yang in equilibrium ", and final realize is controlled Disease seeks this effect.

Invention content

In order to solve the deficiencies in the prior art, the present invention provides it is a kind of for treat coronary heart disease Chinese medicine composition and its Preparation method, the Chinese medicine composition in terms of coronary heart disease disease is treated, have it is curative for effect, toxic side effect is small, significantly improves trouble The advantages of person's quality of life.

To achieve the above object, first purpose of the invention is to provide a kind of Chinese traditional medicine composition for being used to treat coronary heart disease Object, the Chinese medicine composition include the bulk pharmaceutical chemicals of following parts by weight：

20~45 parts of Radix Astragali, 6~12 parts of cassia twig, 15~30 parts of hawthorn, 10~30 parts of Radix Salviae Miltiorrhizae, 15~40 parts of Caulis Spatholobi, pool Rush down 10~20 parts, 10~35 parts of Radix Angelicae Sinensis, 15~20 parts of dried orange peel, 15~20 parts of campanulaceae, 5~20 parts of oriental wormwood, 20~45 parts of kuh-seng is yellow Even 3~15 parts, 12~40 parts of spina date seed.

Preferably, the Chinese medicine composition includes the bulk pharmaceutical chemicals of following parts by weight：20~35 parts of Radix Astragali, cassia twig 6~9 Part, 15~25 parts of hawthorn, 10~20 parts of Radix Salviae Miltiorrhizae, 15~30 parts of Caulis Spatholobi, 10~20 parts of rhizoma alismatis, 10~25 parts of Radix Angelicae Sinensis, dried orange peel 15 ~20 parts, 15~20 parts of campanulaceae, 5~15 parts of oriental wormwood, 20~35 parts of kuh-seng, 3~10 parts of the coptis, 12~30 parts of spina date seed.

Second object of the present invention is to provide the later total feasible of the above-mentioned Chinese medicine composition for being used to treat coronary heart disease Preparation method includes the following steps：

S1：20~45 parts of Radix Astragali, 6~12 parts of cassia twig, 15~30 parts of hawthorn, Radix Salviae Miltiorrhizae 10~30 are weighed according to parts by weight Part, 15~40 parts of Caulis Spatholobi, 10~20 parts of rhizoma alismatis, 10~35 parts of Radix Angelicae Sinensis, 15~20 parts of dried orange peel, 15~20 parts of campanulaceae, oriental wormwood 5~ 20 parts, 20~45 parts of kuh-seng, 3~15 parts of the coptis, 12~40 parts of spina date seed is spare；

S2：Each bulk pharmaceutical chemicals are mixed, the ethyl alcohol for being equivalent to each 4~8 times of amounts of bulk pharmaceutical chemicals total weight is charged with, impregnates 1 ~2.0h, heating extraction 2~4 times later, 1~2.0h, merges extracting solution every time；Then 100~150 mesh filter, then through shutting off Molecular weight be 5000~12000 ultrafiltration column carry out ultrafiltration, ultrafiltrate be concentrated under reduced pressure into relative density for 65~75 DEG C when 1.2~ 1.25 medicinal extract is stood, and obtains component ɑ；

S3：The dregs of a decoction that S2 ethyl alcohol extracted are added into 8~12 times of amount distilled water, heating and refluxing extraction 2~4 times, every time 1.0~ 2.5h merges extracting solution, stands, and obtains component β；

S4：Component ɑ and component β is merged, is filtered, liquor strength is then concentrated under reduced pressure into as 1.0~1.2g/mL, through big Macroporous adsorbent resin column carries out polishing purification, obtains Chinese medical extract, the extracting solution, which is conventionally made, can pharmaceutically connect The pharmaceutical preparation received.

Preferably, the pharmaceutical dosage form of the oral drug preparation is tablet, capsule, granule, Disket or pill.

Preferably, in S4, the detailed process of polishing purification is as follows：

Liquid after reduced pressure through large pore resin absorption column is adsorbed, is washed with the distillation of 8~12 times of resin column volumes It is de-, then the anhydrous ethanol elution with 4~6 times of resin column volumes, ethanol eluate is collected, solvent is removed, obtains Chinese medical extract.

Third object of the present invention is to provide above-mentioned feasible for treating the another kind of the Chinese medicine composition of coronary heart disease Preparation method includes the following steps：

Step 1：20~45 parts of Radix Astragali is weighed according to parts by weight, 6~12 parts of cassia twig, 15~30 parts of hawthorn, Radix Salviae Miltiorrhizae 10~ 30 parts, 15~40 parts of Caulis Spatholobi, 10~20 parts of rhizoma alismatis, 10~35 parts of Radix Angelicae Sinensis, 15~20 parts of dried orange peel, 15~20 parts of campanulaceae, oriental wormwood 5 ~20 parts, 20~45 parts of kuh-seng, 3~15 parts of the coptis, 12~40 parts of spina date seed is spare；

Step 2：Each bulk pharmaceutical chemicals are ground into particle, soak 1~2.5h, soaked bulk pharmaceutical chemicals are added water to cook 2 ~4 times, the water of 8~10 times of amounts of bulk pharmaceutical chemicals is added up for the first time, 1.5~2h is decocted, takes decocting liquid, is filtered；Raw material 3~5 is added up later The water of amount again decocts 1~2h, takes 2~4 decocting liquids mixing, and filtration obtains filtrate；

Step 3：When concentrating filtrate to 70~80 DEG C relative density be 1.1~1.2 concentrate, set to 0~5 DEG C it is low Temperature refrigeration 20~for 24 hours；

Step 4：Add diatomite, filtering, filtrate decompression concentration into the refrigeration liquid that step 3 obtains, and be dried to powder, so Powder is conventionally made to pharmaceutically acceptable pharmaceutical preparation afterwards.

Preferably, the pharmaceutical dosage form of the pharmaceutical preparation is tablet, capsule, granule, Disket or pill.

Compared with prior art, the beneficial effects of the present invention are：

(1) each bulk pharmaceutical chemicals of oral traditional Chinese medicine composition of the present invention press " monarch ", precise and appropriate compatibility, and Radix Astragali can promote saponin(e pair Cardiac muscle has positive inotropic action, can enhance myocardial contractive power, protects cardiovascular system, anti-arrhythmia cordis, coronary artery dilator and Peripheral blood vessel reduces blood pressure, and can reduce platelet adhesion reaction power, reduces thrombosis；Also reducing blood lipid, anti-aging, anti anoxia；Osmanthus Branch water decoction drug administration by injection, can increase coronary blood flow, increase myocardial alimentary blood flow, and cassia twig distillate can reduce isolated rat Heart ischemia reperfusion room is quivered incidence, improves heart function, has inhibiting effect to platelet aggregation, and have antithrombase effect. Haw thorn extract energy coronary artery dilator increases coronary flow, Ischemic myocardium anoxic；It and can cardiac stimulant, blood pressure lowering and the anti-heart Restrain not normal, platelet aggregation-against, anti-oxidant, enhancing is immune.Radix Salviae Miltiorrhizae can expand coronary artery, increase coronary blood flow, improve cardiac muscle and lack Blood promotes the recovery of myocardial ischemia or damage, reduces myocardial infarct size, can improve hypoxia-bearing capability, have guarantor to hypoxic cardiac muscle Shield acts on；Microcirculation can be improved, promote velocity of blood flow；Blood vessel can be expanded, is reduced blood pressure, hemorheological property can be improved, reduces blood Fluid viscosity inhibits blood platelet and coagulation function, activates fibrinolytic, to antithrombus formation, can protect erythrocyte membrane, can adjust blood fat, Inhibit the formation of atherosclerotic plaque.Caulis Spatholobi water extract-alcohol precipitation preparation can increase experimental animal femoral artery blood flow, reduce Vascular resistence has obvious inhibiting effect to platelet aggregation；Water decoction can reduce animal cholesterol, hence it is evident that confrontation Atherosclerosis Change lesion；Water extract and tincture have apparent anti-inflammatory effect, and have two-way regulating function to immune system；The upper five tastes are monarch drug in a prescription, Tonifying Qi promoting circulation of blood, stagnation resolvation analgesic therapy, disperse blood stasis and dredge collateral expand blood vessel, increase coronary flow, and Ischemic myocardium oxygen-starved tissue reduces blood Liquid viscosity, antithrombus formation, nourishing heart of gathering altogether enrich blood removing blood stasis and relieving pain the benefits of；Radix Astragali matches cassia twig, harmonizing yingfen and weifen, and solid protection fleshy exterior increases Strong body resists exopathogen invasive ability, effectively prevents coronary heart disease and inducement occurs.Rhizoma alismatis and its extract have antihypertensive effect, hence it is evident that Increase coronary flow, heart rate is had no significant effect, to myocardial contractive power in slight inhibiting effect, make experimental Atherosclerosis The endarterium patch for changing rabbit is significantly thinning, and the foam cells number of plies and quantity significantly reduce under inner membrance, vascular smooth muscle cells Hyperplasia and cell infiltration mitigate, anti-oxidant, and calcium in arterial wall is inhibited to increase extremely.Eumenol has significantly expansion isolated guinea pig Coronary artery acts on, and increases coronary blood flow, and after anesthetized dog intravenous Radix Angelicae Sinensis, heart rate is without substantially changeing, coronary resistance and total peripheral resistance Decline, coronary blood flow dramatically increases, and oxygen consumption of myocardium is remarkably decreased, and heart discharge and heartbeat index have increase trend, Radix Angelicae Sinensis Neutral oil also has obvious protective function to expeirmental myocardial ischemia.Radix Angelicae Sinensis and its sodium ferulate have apparent anti thrombotic action, when Return infusion that can remarkably promote the generation of hemoglobin and red blood cell to Mouse oral.The a small amount of decoctions of dried orange peel can enhance heart contraction Power increases cardiac output, and coronary dilation increases coronary flow, and heart is can inhibit when large dosage of；The water-soluble total biology of dried orange peel Alkali has raising blood pressure effect；Dried orange peel extracts have scavenging activated oxygen and lipoid peroxidization resistant.Oriental wormwood has notable cholagogic Effect, and have antipyretic, liver protection, antitumor and antihypertensive effect.Its decoction has rabbit experiment hypercholesterolemia in reduction courage Sterol and the effect for inhibiting LDL oxidative modifications.Jujuboside class shows have obvious protective function to cardiovascular system, with acid Jujube kernel total saposins are injected intraperitoneally in 64mg/ (mld), and continuous 20 days, the total courage that can be substantially reduced normal raising rat serum was consolidated Alcohol and low density lipoprotein cholesterol.Prompting jujuboside can be formed by reducing blood fat and conditioning blood lipoprotein to artery congee The formation and development of sample hardening has an effect.Jujuboside, flavonoid glycoside, water and alcohol extracting thing be respectively provided with tranquilizing soporific and Antiarrhythmic effect, and the central inhibitory action of barbiturate can be cooperateed with.The five tastes are ministerial drug, and auxiliary monarch drug in a prescription expansion is coronal Artery increases blood flow, antiatherosclerosis.Kuh-seng has heart apparent inhibiting effect, can make decreased heart rate, and cardiac muscle is received Contracting power weakens, and cardiac output is reduced；Kuh-seng, matrine, kuh-seng flavones have anti-arrhythmia cordis to act on；Lightyellow sophora root injection is to the rhizome of Chinese monkshood Arrhythmia cordis caused by alkali, effect is very fast and lasting, and has antihypertensive effect.Energy excited heart during jamaicin low dose contained by the coptis, Enhance its convergent force, increase coronary blood flow, inhibit heart when large dosage of, weaken its contraction；Jamaicin can reduce toad Heart rate plays the role of excitation to rabbit, cavy, isolated rat atrium and has anti-arrhythmia cordis, has cholagogic, inhibits gastric juice point Secrete, anti diar rhea the effects that, low dose has the excited process of Cerebral Cortex a booster action, large dosage of then have to process of inhibition Booster action has anti-inflammation, anticancer, inhibits the effects that tissue metabolism；Jamaicin and N-1 can reduce cardiac muscle Oxygen demand.In coronary artery dilator, increase blood flow, two taste adjutants are added among the monarch drug in a prescription ministerial drug of antiatherosclerosis, from Entirety sees that monarch drug in a prescription ministerial drug slightly produces warm, adds in kuh-seng, coptis assistant Zhi Qire, has no effect on monarch drug in a prescription ministerial drug and play a role, all the better Effective excitement heart, enhances its convergent force, increases coronary blood flow.Make medicine campanulaceae, there is antitussive effect, have enhancing it is anti-inflammatory And immunization.Anesthetized dog intra-arterial injection platycodin can significantly reduce hind leg blood vessel and resistance coronarius, increase blood Flow.Rat intravenous injection platycodin, it is seen that temporary blood pressure decline, decreased heart rate and respiration inhibition, as dosage increases, Duration extension.The thick saponin(e of campanulaceae has calm, analgesia, refrigeration function, and the hypoglycemic, norcholesterol of energy, relaxing smooth muscle.It rises Guiding action acts on, and carries medicine uplink, strengthens coronary artery dilator, increases blood flow, the effect of antiatherosclerosis.More than institute Each material medicine compatible use is stated, the tonifying Qi promoting flow of qi and blood circulation, the turbid dissipating phlegm and removing blood stasis of row, heat-clearing dredging collateral to stop pain, beneficial spleen cardiac stimulant is gathered altogether and allays excitement The effect of, hypoxia-bearing capability is improved, increases blood flow, the formation of atherosclerotic plaque can be inhibited, suitable for treating the stagnation of the circulation of vital energy Hemostasis phlegm coagulates and the scorching uneasy type patients with coronary heart disease of the deficiency of blood.

(2) reason of the traditional Chinese medical science " treatment of disease must aim at its pathogenesis " is used provided by the present invention for treating the Chinese medicine composition of coronary heart disease It reads, heat-clearing dredging collateral to stop pain, beneficial spleen cardiac stimulant are allayed excitement simultaneously on the basis of the tonifying Qi promoting flow of qi and blood circulation, the taking stopgap measures of the turbid dissipating phlegm and removing blood stasis of row, especially The scorching uneasy type patients with coronary heart disease of the simultaneous deficiency of blood is coagulated suitable for treatment stagnation of the circulation of vital energy hemostasis phlegm.In clinical test, present invention treatment coronary disease The traditional Chinese medicine composition for treating significant effect of disease, total effective rate are up to 91%, and obvious effective rate is up to 71%.

Specific embodiment

In order to which those skilled in the art is enable to more fully understand, technical scheme of the present invention is practiced, with reference to specific The invention will be further described for embodiment, but should not be construed as the limitation of the present invention.Actual conditions are not specified in Examples below Experimental method, carried out according to the conventional method of this field and condition.

The present invention provides a kind of Chinese medicine composition for being used to treat coronary heart disease, and the Chinese medicine composition includes following parts by weight Several bulk pharmaceutical chemicals：20~45 parts of Radix Astragali, 6~12 parts of cassia twig, 15~30 parts of hawthorn, 10~30 parts of Radix Salviae Miltiorrhizae, 15~40 parts of Caulis Spatholobi, 10~20 parts of rhizoma alismatis, 10~35 parts of Radix Angelicae Sinensis, 15~20 parts of dried orange peel, 15~20 parts of campanulaceae, 5~20 parts of oriental wormwood, 20~45 parts of kuh-seng, 3~15 parts of the coptis, 12~40 parts of spina date seed.

Above-mentioned raw materials medicine is respectively provided with the effect of following and effect：

Radix Astragali：Sweet, tepor, return lung, the spleen channel.Tonifying Qi and lifting yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema, blood-nourishing of promoting the production of body fluid, the stagnant logical numbness of row, Pus draining and toxin expelling, expelling pus and promoting granulation.It cures mainly：Syndrome of deficiency of spleen qi, syndrome of deficiency of lung qi, spontaneous perspiration due to deficiency of vital energy card, deficiency of qi and blood, sore difficulty burst it is difficult rotten or Long difficulty of bursting is held back.《Sheng Nong's herbal classic》：" curing mainly ulcer, lose sore, Apocenosis pain relieving ... qi-restoratives long "；《Collected statements on the herbal foundation》：" tonifying lung is good for Spleen, defends arrest sweating in fact, and wind dispelling transports the medicine of poison "；《Records of Tradition Chinese and Western Medicine in Combination》：" can tonifying Qi, and gas can be risen, it is kind to control in the heart that air is (i.e. Pectoral qi) sink "；Modern pharmacology research confirms：Radix Astragali can promote saponin(e to have positive inotropic action to cardiac muscle, with cardiac glycosides medicine Object is similar；Radix Astragali can promote organism metabolism, update that is antifatigue, promoting serum and hepatic protein；There is apparent diuresis, Jishengshenqiwan Urine proteins can be eliminated；Anaemia animal phenomenon can be improved；Hypoglycemia can be increased, reduces hyperglycemia；It can excited breathing； It can enhance and adjust body's immunity, have facilitation to interferon system, the premunition of body can be improved；Infected by influenza There is slight inhibiting effect etc. a variety of viral institute cytopathogenic effects, influenza virus infected has protective effect；Have wide Antibacterial action；Radix Astragali can make cell number showed increased in cell culture, and cell growth is vigorous, and the service life extends；It can enhancing cardiac muscle Convergent force protects cardiovascular system, anti-arrhythmia cordis, coronary artery dilator and peripheral blood vessel, reduces blood pressure, can reduce blood platelet Adhesion strength reduces thrombosis；Also reducing blood lipid, anti-aging, anti anoxia, radioresistance, liver protection the effects that.

Cassia twig：Acrid, sweet, warm.The thoughts of returning home, lung, bladder warp.Sweating expelling pathogenic factors from muscles and skin, warming meridian, helps yang transforming qi.It cures mainly：Chill sense It emits, all pain cards of congealing cold with blood stasis, phlegm and retained fluid, blood stagnation syndrome, palpitaition.《Medicine origin》：“《Cure mainly secret formula》：Remove anemogenous headache, loosing the interspaces of skin and muscles, Skin rheumatism is gone in inducing diaphoresis "；《Bencao Jingshu》：" real table eliminating evil.Main benefitting liver and lung gas, headache, wandering arthritis arthralgia "；《Book on Chinese herbal medicine is standby It will》：" warming meridians and promoting circulation of qi, sweating expelling pathogenic factors from muscles and skin "；Modern pharmacology research confirms：Cassia twig water decoction drug administration by injection, can increase coronary blood flow Amount increases myocardial alimentary blood flow.Cassia twig distillate can reduce isolated rat heart ischemia-reperfusion room and quiver incidence, improve the heart Function.Cassia twig can reduce the release of myocardial lactate dehydrogenase and creatine phosphokinase, reduce LPO generations, improve SOD activity.Osmanthus The branch expansible peripheral blood vessel of water decoction, improves microcirculation, and can accelerate the recovery of body temperature.Cinnamic alcohol is in vitro to platelet aggregation There is inhibiting effect, and have antithrombase effect.

Hawthorn：It is sour, sweet, tepor.Returns spleen, stomach, Liver Channel.Promoting digestion and removing indigestion, scattered stasis.It cures mainly：Eating accumulation is demonstrate,proved, rush down dysentery abdomen Bitterly, hernia pain, stasis blocking chest and abdomen pain, dysmenorrhoea.《Tang materia medica》：" juice takes main water conservancy, washes one's hair sore in head and ablution and itches "；《Daily Grass》：" helping digestion is accumulated, row knot gas, the wide diaphragm of stomach invigorating, the blood mass at the right hypochondrium that disappears block "；《Compendium of Materia Medica》：" change diet, disappear meat Ji , Disorder lumps in the abdomen, phlegm and retained fluid ruffian Full acid regurgitation, stagnant blood distending pain "；Modern pharmacology research confirms：Institute's fatty acids can promote fat digestion, and increase gastric juice It secretes and promotes digestion, and have certain corrective action to gastrointestinal function.Its extract energy coronary artery dilator increases coronary artery stream Amount, Ischemic myocardium anoxic；It and can cardiac stimulant, blood pressure lowering and anti-arrhythmia；Reducing blood lipid again, antiatherosclerosis, drop Low serum cholesterol and triglycerides, it may be possible to by improving serum middle-high density cholesterol and its subfraction concentration, increase courage The excretion of sterol and realize.In addition, hawthorn can also platelet aggregation-against, anti-oxidant, enhancing is immune, diuresis, calmness, shrinks son Palace, antibacterial etc..

Radix Salviae Miltiorrhizae：Hardship is slightly cold.The thoughts of returning home, pericardium, Liver Channel.Promoting blood circulation for regulating menstruation, stasis-dispelling and pain-killing, cool blood to disappear carbuncle, relieving restlessness are calmed the nerves.It cures mainly： Irregular menstruation, amenorrhoea dysmenorrhoea, postpartum stasis of blood, blood stasis is pained, epigastric pain, lumps in the chest and abdomen, traumatic injury and rheumatism bi Zheng, Sore and toxic, pyreticosis agitation coma and palpitation and insomnia.《Japan hanako materia medica》：" blood-nourishing sedate leads to reason joint, controls cold and hot labor, joint Tired pain, four limbs are unsuccessful；Row of the bulge relieves pain, and myogenic is put on flesh；Broken place blood, mends new green blood；Peaceful tire, falls stillborn foetus；Hemostasis is collapsed under band, adjusts woman People's passages through which vital energy circulates is irregular, and blood evil thought is tired of；Malignant sore mange, goitre are gone to live in the household of one's in-laws on getting married pyogenic infections, erysipelas；Headache, cute conjunctivitis；Pyreticosis is violated bored "；《The southern regions of the Yunnan Province book on Chinese herbal medicine》：It " mends Heart sedate, calming heart and tranquilizing mind.Forgetful palpitation is controlled, palpitation with fear is insomnia "；《Book on Chinese herbal medicine is just read》：" Radix Salviae Miltiorrhizae, same four objects of work(, energy dissolving stasis is new with life, It is kind to treat wind and dissipating bind, it is mild-natured and and walk blood ... ... sweet-bitter flavor with menstruation regulating, but specially logical battalion point.Though Radix Salviae Miltiorrhizae has ginseng name, it is enriched blood Power is insufficient, and the power of promoting blood circulation is had a surplus, to improve medicine first of blood system.It goes to tie long-pending person so treating wandering arthritis, and also blood wind is from going out, and blood is then Long-pending voluntarily ear "；Modern pharmacology research confirms：Coronary artery can be expanded, increases coronary blood flow, improves myocardial ischemia, promotes cardiac muscle Myocardial infarct size is reduced in ischemic or the recovery of damage；Hypoxia-bearing capability can be improved, has protective effect to hypoxic cardiac muscle；It can change Kind microcirculation, promotes velocity of blood flow；Blood vessel can be expanded, is reduced blood pressure.Hemorheological property can be improved, reduce blood viscosity, inhibited Blood platelet and coagulation function activate fibrinolytic, to antithrombus formation；Erythrocyte membrane can be protected.Blood fat can be adjusted, inhibits artery athero- The formation of plaque.Hepatocellular injury can be protected, promotes liver cell regeneration, there is effect of anti hepatic fibrosis.Can promote fracture and The healing of skin incision.Gastric mucosa, anti-gastric-ulcer can be protected.Central nervous has calm and analgesic activity.With improvement kidney function It can, protect the effect of Ischemic kieney injury.With anti-inflammatory, antianaphylactic effect.To staphylococcus aureus, a variety of bacillus, certain A little tinea bacterium and Leptospira etc. have different degrees of inhibiting effect.

Caulis Spatholobi：Bitter, micro- sweet, warm.Return liver and kidney channel.Promoting circulation of blood is enriched blood, menstruation regulating, relaxing tendons and activating collaterals.It cures mainly：Irregular menstruation, pain Through, amenorrhoea, arthralgia pain due to rheumatism is numb in every limb, quadriplegia and blood deficiency chlorosis.《A Supplement to the Compendium of Materia Medica》：" its rattan is most invigorated blood circulation, and warms up waist Knee, paralysis "；" it strengthens the bone, punish-old people's deficient qi and blood of having ached and wine takes ..., numb in every limb, the cards such as paralysis；Man is empty Damage, it is impossible to fertility and seminal emission gonorrhoea ... married woman's irregular menstruation, leukorrhea with reddish discharge；The empty cold conception failture of married woman's blood emaciation and uterus "；《Medicine materical crude slice is newly joined》：" remove hemostasis, raw new blood, fluent passages through which vital energy circulates.Control heat acute diseases such as cholera and sunstroke, wind blood-arthralgia disease "；《Modern Practical Chinese medicinal》：" for robustness Antianaemics, suitable for anemicus neural paralysis disease, such as limbs and lumbocrural pain, apathy etc..It is used for woman in menstrual period again It is uncomfortable, menstruation apolipsis etc..There is the benefits of invigorating blood circulation analgesia "；Modern pharmacology research confirms：Water extract-alcohol precipitation preparation can increase experimental animal Femoral artery blood flow reduces vascular resistence, has obvious inhibiting effect to platelet aggregation；Water decoction can reduce animal cholesterol, Apparent confrontation atherosclerotic lesion；Water extract and tincture have apparent anti-inflammatory effect, and have bidirectional modulation to immune system Function；Tincture has certain sedative-hypnotic effect；Parenteral solution or gavage have mouse apparent Robust speaker feature to act on；Caulis Spatholobi still can Promote the total phosphorus metabolism of Mouse Kidney, promote Mouse Uterus total phosphorus metabolism in 24 hours.

Campanulaceae：It is bitter, pungent, it puts down.It is distributed in lung channel.Facilitaing lung, eliminating the phlegm, relieving sore-throat, apocenosis.It cures mainly：Coughing with a lot of sputum, chest distress, throat Swelling and pain, aphonia, lung carbuncle pyemesis.《Sheng Nong's herbal classic》：" main chest and hypochondrium such as lancination, it is faint that abdomen expires borborygmus, gas of throbbing with fear in terror "；《Pearl Capsule drug property cerse》：" it is with having four：Only pharyngalgia, and except nasal obstruction；Sharp diaphragm gas, still controls lung carbuncle；One is the ships of all medicines；One for lung it Tying-in "；《Book on Chinese herbal medicine covers bamboo fish trap》：" chest diaphragm is opened, except upper gas is stopped up, refresh oneself dissipates exterior cold heresy, drives the lower shouting pain of the side of body, is stopped up in logical nose, throat Swelling and pain are anxious to look for, and by lung heat, firmly cough, lower phlegm control lung carbuncle apocenosis, and blood-nourishing still disappears and is enraged, especially but palpitation "；Modern pharmacology research is demonstrate,proved It is real：Campanulaceae has antitussive effect, and having enhances anti-inflammatory and immunization, and anti-inflammatory intensity is similar to aspirin；Water extract can enhance The phagocytic function of macrophage enhances the sterilizing power of neutrocyte, improves lysozyme activity；There is prevention to make to stress ulcer With.Anesthetized dog intra-arterial injection platycodin can significantly reduce hind leg blood vessel and resistance coronarius, increase blood flow.Greatly Mouse is injected intravenously platycodin, it is seen that temporary blood pressure decline, decreased heart rate and respiration inhibition, as dosage increases, when continuing Between extend.The thick saponin(e of campanulaceae has calm, analgesia, refrigeration function, and the hypoglycemic, norcholesterol of energy, relaxing smooth muscle.

Rhizoma alismatis：It is sweet, it trembles with fear.Return kidney, bladder warp.Inducing diuresis for removing edema, excreting dampness expel the heat-evil.It cures mainly：Oedema, difficult urination, diarrhea, leaching Card, seminal emission.《Haigoushen》：" main kidney deficiency essence goes out certainly, controls five leaching, and sharp bladder heat declares water flowing "；《Herbal outline》：" dehumidifying is treating stranguria, Quench the thirst, harness the river swollen, antidiarrheal dysentery helps it with umbellate pore furgus "；《Compendium of Materia Medica》：" excreting dampness heat, row phlegm and retained fluid, anti-nausea, rush down dysentery, colic, foot Gas "；Modern pharmacology research confirms：Rhizoma alismatis and its extract have antihypertensive effect, and antihypertensive effect blocks and presses down with calcium ion Sympathetic neuron release norepinephrine processed is related.Isolated rabbit experiment shows that the water-soluble portion of rhizoma alismatis alcohol extracting thing is bright It is aobvious to increase coronary flow, heart rate is had no significant effect, is in slight inhibiting effect to myocardial contractive power.The Aqueous extracts of rhizoma alismatis are in body There is inhibiting effect to the AA or ADP platelet aggregations induced outside.Alisma extract can make Experimental Atherosclerotic Rabbits Endarterium patch it is significantly thinning, the foam cells number of plies and quantity significantly reduce under inner membrance, vascular smooth muscle cell curing and Cell infiltration mitigates, and experiment confirms the mechanism of rhizoma alismatis antiatherosclerosis and its reducing blood lipid, increasing high density lipoprotein, adjusts The dynamic equilibrium of PGI2/TXA2 is saved, it is anti-oxidant, inhibit calcium raising extremely and improvement hemorheological property etc. in arterial wall a variety of It acts on related.

Radix Angelicae Sinensis：Sweet, acrid, warm.Return liver, the heart, the spleen channel.Tonifying blood and regulating menstruation promoting blood circulation and stopping pain, relaxes bowel.It cures mainly：The all cards of the deficiency of blood, Irregular menstruation, Amenorrhea, dysmenorrhoea of blood deficiency and blood stasis etc., deficient cold type abdominal pain, traumatic injury, ulcer sores, chill numbness pain etc., deficiency of blood intestines Dry constipation.《Sheng Nong's herbal classic》：" main cough with dyspnea, a kind of malaria fever and chills are washed in skin.Married woman is leaked down exhausted son, all malignant sore ulcers, gold Sore "；《Japan hanako materia medica》：" curing mainly a wind cutting, all blood mend all labor, break extravesated blood, support new blood and main Disorder addictions "；《Medicine opens Source》：" Radix Angelicae Sinensis, temperature is sweet in flavor, can enrich blood with blood, tail blood-breaking, body and blood "；《Compendium of Materia Medica》：" control a carbuncle, all pains of trusted subordinate, ease constipation Stomach, muscles and bones, skin, control ulcer, and Apocenosis pain relieving and blood are enriched blood "；《Essentials of Materia Medica》：" moisturize laxation "；Modern pharmacology research is demonstrate,proved It is real：Chinese angelica volatile oil can be to the excitation of liquid element or histamine to uterus after antiadrenergic drug-pituitary.Radix Angelicae Sinensis water or alcohol Dissolubility nonvolatile confrontation isolated uterine has excitation, strengthens uterine contractile, during a large amount of or multiple dosing or even can go out Existing tetanic contraction, alcohol-soluble material effect are stronger than water-soluble substances effect.Isolated Toad Heart perfusion experiment, this product decoction contain Volatile oil can be such that shrinkage amplitude and contraction frequency all significantly inhibits.Eumenol has significantly expansion isolated guinea pig coronary effect, increases Add coronary blood flow.Anesthetized dog intravenous this product heart rate is without substantially changeing, and coronary resistance and total peripheral resistance decline, coronary blood flow It dramatically increases, oxygen consumption of myocardium is remarkably decreased, and heart discharge and heartbeat index have increase trend.Radix Angelicae Sinensis neutral oil is to the experimental heart Myocardial ischemia also has obvious protective function.Radix Angelicae Sinensis and its sodium ferulate have apparent anti thrombotic action.Radix Angelicae Sinensis infusion is to mouse mouthful Clothes can remarkably promote the generation of hemoglobin and red blood cell.

The coptis：Hardship is trembled with fear.The thoughts of returning home, spleen, stomach, courage, large intestine channel.Heat-clearing and damp-drying drug, purging intense heat and detonicating.It cures mainly：Damp and hot feeling of fullness, vomiting Acid regurgitation, damp-heat dysentery, unconsciousness due to high fever, dysphoria and insomnia, blood-head tells nosebleed, carbuncle swells furuncle sore, hot eyes toothache quench one's thirst, control eczema, wet outside Sore, duct are suppurated.《Sheng Nong's herbal classic》：" main hot gas mesh pain, corner of the eyes wound weep, spouting bleeding from anus abdominal pain diarrhea, swell and ache in married woman's the moon "；《It is precious Pearl capsule》：" it is with having six：Purge the sthenic heart-fire, one；Remove dampness-heat in middle jiao, two；All sores must be used, and three；Curing rheumatism, four；Control cute conjunctivitis It breaks out, five；Only blood is seen at middle part, six "；《Herbal justice》：" coptis big bitter Great Cold, bitter eliminating dampness, cold prevailing over heat, can drop-down all The wet fire having a surplus, and the heart, spleen, liver, kidney heat, courage, stomach, intestine and small intestine fire, control it invariably.On with the mesh of fresh breeze fire disease, in The vomiting of soothing the liver stomach, under with lead to abdominal pain it is stagnant under, all eliminating dampness heat-clearing the benefits of.Bitter flavor entering the heart first again, washs clearly blood-head, therefore blood man is all Disease, such as hematemesis haematuria, stranguria with turbid discharge of having blood in stool, anal fistula collapses cards and the large carbuncle macula erysipelas such as band, and all relies on for support in this.Modern pharmacology is ground Study carefully confirmation：This product is to staphylococcus, streptococcus, pneumococcus, comma bacillus, bacillus anthracis and the dysentery bar in addition to sonnei Bacterium has stronger antibacterial action；To pneumobacillus, corynebacterium diphtheriae, hay bacillus, Bordetella pertussis, yersinia pestis, Bu Shi bars Bacterium, tubercle bacillus also have antibacterial action；It is poor to Escherichia coli, proteus, typhoid bacillus effect；Contained jamaicin is low dose of When can excited heart, enhance its convergent force, increase coronary blood flow, inhibit heart when large dosage of, weaken its contraction；Barberry Alkali can reduce toad heart rate, play the role of excitation to rabbit, cavy, isolated rat atrium and have anti-arrhythmia cordis, have cholagogic, The effects that inhibiting gastric secretion, anti diar rhea, low dose has the excited process of Cerebral Cortex booster action, large dosage of then right Process of inhibition has booster action, has anti-inflammation, anticancer, inhibits the effects that tissue metabolism；Jamaicin and N-1 energy Reduce the oxygen demand of cardiac muscle；The coptis and its extract component have anti-ulcer effect.

Dried orange peel：It is pungent, bitter, temperature.Returns spleen, lung channel.Regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm.It cures mainly：Taste syndrome of qi stagnation, vomiting, hiccup Card, damp phlegm, cold productive cough are coughed, obstruction of qi in the chest card.《Sheng Nong's herbal classic》：" the main heat of lump in the abdomen in the heart, inverse gas, sharp trough, long term usage deodorizing, lower gas "；《Mingyi Bielu》：" lower gas, preventing or arresting vomiting cough "." main spleen unable to digest food, gas rush in the heart, spit inverse cholera, stopping leak "；《Compendium of Materia Medica》：It " treats Sound of vomiting gastric disorder causing nausea of vomitting is noisy, when hydroptysis, phlegm ruffian cough malaria, stool occlusion, married woman's acute mastitis enters foodstuff, solution fish raw meat poison "；" it controls all kinds of diseases and ailments, Always take the work(of its qi-regulating eliminating dampness.It then mends with tonic, is then rushed down with cathartic, then risen with hydrargyrum oxydatum crudum, then dropped with medicine is dropped "；Modern pharmacology is ground Study carefully confirmation：This product decoction has direct repression to rabbit and small white mouse intestine in vitro, anesthetized rabbit, dog stomach and bowel movement；It is small Amount decoction can enhance cardiac contractile force, increase cardiac output, coronary dilation increases coronary flow, can inhibit when large dosage of Heart；Dried orange peel water solubility total alkaloid has raising blood pressure effect；Dried orange peel extracts have scavenging activated oxygen and anti-lipid peroxy Change acts on；Fresh orange peel decoction plays the role of expanding tracheae；The irritant phlegm-dispelling functions of volatile oil, principle active component are lemon Alkene；Dried orange peel decoction has mouse isolated uterine inhibiting effect, and high concentration is then allowed to, in fully relaxed state, be noted with decoction vein It penetrates, to anesthetized rabbit, uterus in place is then allowed in tetanic contraction；There is cholagogic, reduce serum cholesterol effect.

Spina date seed：It is sweet, sour, it puts down.The thoughts of returning home, liver, gallbladder channel.Nourishing heart benefit liver is calmed the nerves, arrest sweating.It cures mainly：Palpitation and insomnia, spontaneous perspiration are stolen Sweat.《Sheng Nong's herbal classic》：" main trusted subordinate's fever and chills, heresy knot gas gather, arthritis with fixed pain caused by dampness of having aches in the limbs, long term usage five viscera settling, macrobiosis of making light of one's life by commiting suicide "；《Name doctor It does not record》：" master is vexed to sleep ... ..., and abnormal sweating, polydipsia, bowl spares, beneficial irritability, hard muscles and bones help cloudy gas "；《Compendium of Materia Medica》：" its benevolence Gan Errun, therefore insomnia due to insufficiency of the gallbladder-qi for ripe use treatment, the card of polydipsia abnormal sweating；It is raw to be slept well with treatment gallbladder-heat, all sufficient cloudy, few positive medicine of fainting "；It is modern Pharmaceutical research confirms：Jujuboside class shows have obvious protective function to cardiovascular system, is existed with spina date seed total saposins 64mg/ (mld) is injected intraperitoneally, continuous 20 days, can be substantially reduced the T-CHOL and low density lipoprotein of normal raising rat serum Protein cholesterol.Prompting jujuboside can be by reducing blood fat and improving formation of the blood lipoprotein composition to atherosclerosis There is an effect with development.Jujuboside, flavonoid glycoside, water and alcohol extracting thing are respectively provided with tranquilizing soporific and anti-arrhythmia is made With, and the central inhibitory action of barbiturate can be cooperateed with；Its decocting liquid and alcohol extract are also anticonvulsion, analgesia, drop body Temperature, antihypertensive effect；In addition, spina date seed also have reducing blood lipid, anti anoxia, it is antitumor, inhibit platelet aggregation, enhance immune function and Excited uterus effect.

Kuh-seng：Hardship is trembled with fear.The thoughts of returning home, liver, stomach, large intestine, bladder warp.Heat-clearing and damp-drying drug, desinsection, diuresis.It cures mainly：Damp-heat dysentery, just Blood, jaundice, under humid tropics, swelling of vulva pruritus vulvae, eczema wet sore, pruitus, mange, damp and hot difficult urination.《Sheng Nong's herbal classic》： " main trusted subordinate is depressed, lumps in the chest and abdomen, jaundice, and drowning has the heeltap, relieves oedema or abdominal distension through diuresis or purgation, except carbuncle swells "；《Compendium of Materia Medica》：It " controls intestines wind and rushes down blood, and heat Dysentery "；《Herbal justice》：" kuh-seng, big hardship Great Cold, drop-down of bringing down a fever cleanse wet fire, and effect and a kind of reed mentioned in ancient books, company, rough gentian are all close, and bitter The hardship of ginseng is more, dry outstanding strong, therefore can kill the damp and hot worm given birth to, and compared with a kind of reed mentioned in ancient books, even strength benefit is strong.Person of modern times be dare not to enter decoction, Gai Bute fears its bitter taste difficulty clothes, also dislikes its high strict and keeps away.So poison wind dislikes leprosy, and non-this do not remove, moderns but to be used to wash sore, Probably rather because due to useless food ear "；Modern pharmacology research confirms：This product has heart apparent inhibiting effect, can subtract heart rate Slowly, myocardial contractive power weakens, and cardiac output is reduced；Kuh-seng, matrine, kuh-seng flavones have anti-arrhythmia cordis to act on；Kuh-seng is noted Liquid is penetrated to arrhythmia cordis caused by aconitine, effect is very fast and lasting, and has antihypertensive effect；Its decoction is to tubercle bacillus, dysentery bar Bacterium, staphylococcus aureus, Escherichia coli have inhibiting effect, also have inhibiting effect to a variety of dermatophytes.Also diuresis, anti- Inflammation, antiallergy, calmness, relieving asthma, eliminating the phlegm, increasing leukocyte, it is antitumor the effects that.

Oriental wormwood：It is bitter, pungent, it is slightly cold.Returns spleen, stomach, liver, gallbladder channel.Removing dampness through diuresis and removing jaundice, detoxification sore treatment.It cures mainly：Jaundice, wet sore itch. 《Sheng Nong's herbal classic》：" main rheumatism fever and chills perverse trend, thermojunction jaundice "；《Mingyi Bielu》：" the whole body is turned to be yellow, difficult urination, except headache, Go volt lump in the abdomen "；《Elementary Medicine》：" disappear sore scabies all over "；Modern pharmacology research confirms：Oriental wormwood has notable choleretic effect, and has solution Heat, liver protection, antitumor and antihypertensive effect.Its decoction has reduction cholesterol and inhibition to rabbit experiment hypercholesterolemia The effect of LDL oxidative modifications.Oriental wormwood can promote immunologic mjury to merge the aorta that cholesterol is fed with the experimental AS models of rabbit simultaneously AS lesions and coronary artery AS lesions subside.Its decoction has inhibiting effect to Mycobacterium hominis.Ethanol extract convection current is susceptible Poison has inhibiting effect.Water decoction has inhibiting effect to ECHD11 viruses.

With reference to some specific embodiments, technical scheme of the present invention is further illustrated.

Embodiment 1

The present embodiment is a kind of for treating the Chinese medicine composition of coronary heart disease, includes the bulk pharmaceutical chemicals of following parts by weight：Radix Astragali 25g, cassia twig 6g, hawthorn 15g, Radix Salviae Miltiorrhizae 15g, Caulis Spatholobi 15g, rhizoma alismatis 10g, Radix Angelicae Sinensis 10g, dried orange peel 15g, campanulaceae 15g, oriental wormwood 5g, Kuh-seng 20g, coptis 3g, spina date seed 12g.

The preparation method of above-mentioned Chinese medicine composition includes the following steps：Each raw material is weighed according to above-mentioned weight, by each raw material Medicine mixes, and is charged with the ethyl alcohol for being equivalent to each 6 times of amounts of bulk pharmaceutical chemicals total weight, impregnates 1.0h, later 80 DEG C of heating extractions 3 Secondary, each 1h merges extracting solution；Supernatant is taken after standing, then 140 mesh filter, then through the ultrafiltration that molecular weight is 5000 of shutting off Column ultrafiltration, ultrafiltrate are concentrated under reduced pressure into when relative density is 70 DEG C 1.2 medicinal extract, and stand for standby use obtains component ɑ；By above-mentioned second The dregs of a decoction of alcohol extracting add 8 times of amount distilled water, and 80 DEG C of heating and refluxing extractions 2 times, each 1.0h merge extracting solution, stand, obtain Component β；Component ɑ and component β is merged, is filtered, liquor strength is then concentrated under reduced pressure into as 1.0g/mL, then through macroporous absorption Resin column adsorbs, and with the distillation water elution of 8 times of resin column volumes, then the anhydrous ethanol elution with 5 times of resin column volumes, collects second Alcohol eluen removes solvent, obtains medicinal powder, is packed into capsule, every 1.2g.

Embodiment 2

The present embodiment is a kind of for treating the Chinese medicine composition of coronary heart disease, includes the bulk pharmaceutical chemicals of following parts by weight：Radix Astragali 30g, cassia twig 8g, hawthorn 10g, Radix Salviae Miltiorrhizae 20g, Caulis Spatholobi 20g, rhizoma alismatis 15g, Radix Angelicae Sinensis 10g, dried orange peel 10g, campanulaceae 10g, oriental wormwood 10g, Kuh-seng 15g, coptis 6g, spina date seed 24g.

The preparation process and embodiment 1 of above-mentioned Chinese medicine composition are identical, the difference is that only the formula of Chinese medicine composition It is different.

Embodiment 3

The present embodiment is a kind of for treating the Chinese medicine composition of coronary heart disease, includes the bulk pharmaceutical chemicals of following parts by weight：Radix Astragali 45g, cassia twig 12g, hawthorn 25g, Radix Salviae Miltiorrhizae 25g, Caulis Spatholobi 35g, rhizoma alismatis 15g, Radix Angelicae Sinensis 30g, dried orange peel 15g, campanulaceae 14g, oriental wormwood 15g, kuh-seng 25g, coptis 9g, spina date seed 30g.

Embodiment 4

The present embodiment is a kind of for treating the Chinese medicine composition of coronary heart disease, includes the bulk pharmaceutical chemicals of following parts by weight：Radix Astragali 40g, cassia twig 10g, hawthorn 16g, Radix Salviae Miltiorrhizae 20g, Caulis Spatholobi 30g, rhizoma alismatis 12g, Radix Angelicae Sinensis 25g, dried orange peel 20g, campanulaceae 15g, oriental wormwood 15g, kuh-seng 16g, coptis 9g, spina date seed 40g.

Embodiment 5

The present embodiment is a kind of for treating the Chinese medicine composition of coronary heart disease, includes the bulk pharmaceutical chemicals of following parts by weight：Radix Astragali 35g, cassia twig 9g, hawthorn 15g, Radix Salviae Miltiorrhizae 20g, Caulis Spatholobi 15g, rhizoma alismatis 10g, Radix Angelicae Sinensis 10g, dried orange peel 10g, campanulaceae 15g, oriental wormwood 15g, Kuh-seng 20g, coptis 6g, spina date seed 36g.

Embodiment 6

The present embodiment is a kind of for treating the Chinese medicine composition of coronary heart disease, includes the bulk pharmaceutical chemicals of following parts by weight：Radix Astragali 45g, cassia twig 6g, hawthorn 25g, Radix Salviae Miltiorrhizae 25g, Caulis Spatholobi 20g, rhizoma alismatis 15g, Radix Angelicae Sinensis 20g, dried orange peel 15g, campanulaceae 15g, oriental wormwood 20g, Kuh-seng 10g, coptis 10g, spina date seed 32g.

Embodiment 7

The present embodiment is a kind of, and for treating the Chinese medicine composition of coronary heart disease, Traditional Chinese medicine composition formula and embodiment 2 are identical, The difference lies in preparation process difference, preparation process provided in this embodiment is specific as follows：

The preparation method of above-mentioned Chinese medicine composition includes the following steps：Each raw material is weighed according to weight, each bulk pharmaceutical chemicals are mixed It closes, is charged with the ethyl alcohol for being equivalent to 5 times of amounts of each bulk pharmaceutical chemicals total weight, impregnate 2.0h, later 80 DEG C of heating extractions 2 times, often Secondary 2h merges extracting solution；Supernatant is taken after standing, then 120 mesh filter, then surpass through the ultrafiltration column that molecular weight is 8000 that shuts off Filter, ultrafiltrate are concentrated under reduced pressure into when relative density is 70 DEG C 1.2 medicinal extract, and stand for standby use obtains component ɑ；Above-mentioned ethyl alcohol is carried The dregs of a decoction taken add 10 times of amount distilled water, and 80 DEG C of heating and refluxing extractions 3 times, each 2.0h merge extracting solution, stand, acquisition group Divide β；Component ɑ and component β is merged, is filtered, liquor strength is then concentrated under reduced pressure into as 1.1g/mL, then through macroporous absorption tree Fat column adsorbs, and with the distillation water elution of 10 times of resin column volumes, then the anhydrous ethanol elution with 6 times of resin column volumes, collects second Alcohol eluen removes solvent, obtains medicinal powder, is packed into capsule, every 0.6g.

Embodiment 8

The present embodiment is a kind of, and for treating the Chinese medicine composition of coronary heart disease, Traditional Chinese medicine composition formula and embodiment 3 are identical, The difference lies in preparation process difference, preparation process provided in this embodiment is specific as follows：

The preparation method of above-mentioned Chinese medicine composition includes the following steps：Each raw material is weighed according to weight, each bulk pharmaceutical chemicals are mixed It closes, is charged with the ethyl alcohol for being equivalent to 6 times of amounts of each bulk pharmaceutical chemicals total weight, impregnate 2.0h, later 80 DEG C of heating extractions 3 times, often Secondary 2h merges extracting solution；Supernatant is taken after standing, then 140 mesh filter, then surpass through the ultrafiltration column that molecular weight is 10000 that shuts off Filter, ultrafiltrate are concentrated under reduced pressure into when relative density is 70 DEG C 1.25 medicinal extract, and stand for standby use obtains component ɑ；Above-mentioned ethyl alcohol is carried The dregs of a decoction taken add 12 times of amount distilled water, and 80 DEG C of heating and refluxing extractions 3 times, each 2.0h merge extracting solution, stand, acquisition group Divide β；Component ɑ and component β is merged, is filtered, liquor strength is then concentrated under reduced pressure into as 1.18g/mL, then through macroporous absorption tree Fat column adsorbs, and with the distillation water elution of 6 times of resin column volumes, then the anhydrous ethanol elution with 6 times of resin column volumes, collects ethyl alcohol Eluent removes solvent, obtains medicinal powder, is packed into capsule, every 1.0g.

Embodiment 9

The present embodiment is a kind of, and for treating the Chinese medicine composition of coronary heart disease, Traditional Chinese medicine composition formula and embodiment 4 are identical, The difference lies in preparation process difference, preparation process provided in this embodiment is specific as follows：

The preparation method of above-mentioned Chinese medicine composition includes the following steps：Each raw material is weighed according to weight, each bulk pharmaceutical chemicals are mixed It closes, is charged with the ethyl alcohol for being equivalent to 5 times of amounts of each bulk pharmaceutical chemicals total weight, impregnate 2.0h, later 80 DEG C of heating extractions 3 times, often Secondary 2h merges extracting solution；Supernatant is taken after standing, then 140 mesh filter, then surpass through the ultrafiltration column that molecular weight is 10000 that shuts off Filter, ultrafiltrate are concentrated under reduced pressure into when relative density is 70 DEG C 1.2 medicinal extract, and stand for standby use obtains component ɑ；Above-mentioned ethyl alcohol is carried The dregs of a decoction taken add 10 times of amount distilled water, and 80 DEG C of heating and refluxing extractions 3 times, each 2.0h merge extracting solution, stand, acquisition group Divide β；Component ɑ and component β is merged, is filtered, liquor strength is then concentrated under reduced pressure into as 1.1g/mL, then through macroporous absorption tree Fat column adsorbs, and with the distillation water elution of 12 times of resin column volumes, then the anhydrous ethanol elution with 6 times of resin column volumes, collects second Alcohol eluen removes solvent, obtains medicinal powder, is packed into capsule, every 1.0g.

Embodiment 10

The present embodiment is a kind of, and for treating the Chinese medicine composition of coronary heart disease, Traditional Chinese medicine composition formula and embodiment 5 are identical, The difference lies in preparation process difference, preparation process provided in this embodiment is specific as follows：

The preparation method of above-mentioned Chinese medicine composition includes the following steps：Each raw material is weighed according to weight, each bulk pharmaceutical chemicals are gone It is miscellaneous, it dries, co-grinding soaks 1h into particle：Soaked raw material is put and is added water to cook in multi-function extractor 2 times, The water of 8 times of amounts of medicinal material is added up for the first time, 1.5h is decocted, takes decocting liquid, is filtered, and the water of second of totalling amount, 3 times of amounts decocts 1h, takes Decocting liquid mixes twice, filtration；Relative density is 1.2 concentrate when the filtrate decompression of filtering is concentrated into 80 DEG C, sets to 0~5 DEG C Deepfreeze is for 24 hours；Refrigeration liquid is added into diatomite, is filtered, filtrate decompression concentration is dried to powder, is packed into capsule, every 0.8g.

Embodiment 11

The present embodiment is a kind of, and for treating the Chinese medicine composition of coronary heart disease, Traditional Chinese medicine composition formula and embodiment 6 are identical, The difference lies in preparation process difference, preparation process provided in this embodiment is specific as follows：

The preparation method of above-mentioned Chinese medicine composition includes the following steps：Each raw material is weighed according to weight, each bulk pharmaceutical chemicals are gone It is miscellaneous, it dries, co-grinding soaks 2h into particle：Soaked raw material is put and is added water to cook in multi-function extractor 3 times, The water of 10 times of amounts of medicinal material is added up for the first time, 2h is decocted, takes decocting liquid, is filtered, and the water of second of totalling amount, 5 times of amounts decocts 1.2h, takes Decocting liquid mixes twice, filtration；Relative density is 1.1 concentrate when the filtrate decompression of filtering is concentrated into 70 DEG C, sets to 0~5 DEG C Deepfreeze 20h；Refrigeration liquid is added into diatomite, is filtered, filtrate decompression concentration is dried to powder, is packed into capsule, every 0.5g.

1~embodiment of embodiment 11 is each provided with therapeutic effect significantly for treating the Chinese medicine composition of coronary heart disease, and Since the traditional Chinese medicine composition for treating effect that 1~embodiment of embodiment 11 provides is substantially parallel, made below only with embodiment 1 For the Chinese medicine composition gone out, the effect of the present invention is illustrated.

Further the effect of the present invention is illustrated using clinical test below.

1st, clinical data

1.1st, general information

Accept outpatient service patients with coronary heart disease totally 160 for medical treatment from 2006.Wherein male 89, women 71,38~82 years old age, Average age 65 years old；The course of disease 0.25~25 year, the course of disease be less than 1 year person 17,1~6 year person 59,6~10 years persons 37,10~ 15 years persons 27,15~20 years persons 20.

1.2nd, diagnostic criteria

Reference《New Chinese medicine guideline of clinical investigations》The middle treatment obstruction of qi in the chest (coronary disease and angina pectoris) standard.

1.2.1 tcm diagnosis

Suffocating pain over the chest, very then chest pain radiating to the back；The lighter only feels chest distress, unsmooth breath；ECG examination has ischemic change Or exercise test is positive.

1.2.2 Standards of Chinese Medical Syndrome Differentiation

The stagnation of the heart blood, stabbing pain over the chest or angina, fixation do not move, and enter Night Watch very, when or palpitation and uneasiness, tongue it is purple dark, deep wiry pulse It is puckery.

1.2.3 Western medicine diagnostic criteria

1. angina pectoris：It is characterized in the transience chest induced by movement or the myocardium aerobic situation of other increases Pain is broken out, and after rest or sublingual administration nitroglycerin, pain can often be alleviated rapidly.

2. spontaneous angina pectoris：It is characterized in the increase of episode and myocardium requirementing keto quantity without obvious relation, with the fatigue heart Angina is compared, and this pain general persistence is longer, and degree is heavier, and is not easy to be alleviated by nitroglycerin.This type has no that enzyme becomes Change, electrocardiogram often occurs temporary S~T sections and forces down change.

1.2.4 weight grade scale uncomfortable in chest

It is 1. slight：Have a classical angina breaking-out, several minutes of each duration, weekly pain at least break out 2~3 times or every Day breaking-out 1~3 time, but pain does not weigh, and needs buccal nitroglycerin sometimes；

2. moderate：There is classical angina breaking-out for several times daily, each last for several minutes to l0min, pain is heavier, generally all Need buccal nitroglycerin；

3. compared with severe：There is multiple classical angina to break out daily, thus influence daily life (such as defecate, wear the clothes), often The secondary breaking-out duration is longer, need to repeatedly suck nitroglycerin；

4. severe：Panic attacks number and degree compare severe and attach most importance to.

1.2.5 case inclusion criteria

With obstruction of qi in the chest primary symptom, diagnosis is clear and definite, meets Western medicine diagnostic criteria and the Chinese medical discrimination category stagnation of the heart blood, breaks out two weekly Secondary above Treating Patients of Angina Pectoris.

1.2.6 exclusion criteria

1. coronary heart disease myocardial infarction or other heart diseases are turned out to be on inspection, severe neurological functional disease, climacteric syndrome, Patient uncomfortable in chest caused by cervical spondylosis.

2. merge moderate more than hypertension, severe cardiopulmonary insufficiency, liver, kidney, hemopoietic system severe primary disease, essence Refreshing patient.

3. under-18s or women breast-feeding their children, those who are allergic to this drug.

4. not meeting inclusion criteria, not by regulation medication, it can not judge that curative effect or data be not congruent, affect the treatment or pacify Full property judgement person.

2.1st, therapy

Two groups deactivate all antianginal drugs in 2 weeks before the treatment, and whens angina pectoris attacks can buccal nitroglycerine tablets.2 weeks Afterwards treatment group take the embodiment of the present invention 1 offer capsule, 1~4 tablet/time, 2~3 times/d.Control group takes orally Tongxinluo medicinal capsule (production of company of Jinlin Aodong Medicine Industry Groups), 3 tablets/time, 3 times/d.Interim buccal nitroglycerine tablets, prohibit when coronary disease and angina pectoris breaks out With other antianginal drugs, 7 days courses for the treatment of, two groups are treated 5 weeks, while give less salt low fat bland diet.

2.2nd, observation of curative effect

2.2.1 criterion of therapeutical effect

According to《New Chinese medicine guideline of clinical investigations》The middle treatment obstruction of qi in the chest (coronary disease and angina pectoris) standard determination.

(1) symptom criterion of therapeutical effect：

1. it is slight, it is effective：Symptom disappear or mostly disappear.Effectively：Panic attacks number, degree and duration have significantly Mitigate.In vain：Symptom with treatment before it is essentially identical.

2. moderate, effective：Symptom disappear or mostly disappear.Effectively：Symptom is relieved to the standard of " slight ".In vain：Symptom With it is essentially identical before treatment.

It is 3. effective compared with severe：Symptom disappears or is relieved to the standard of " slight " substantially.Effectively：Symptom is relieved to " moderate " Standard.In vain：Symptom with treatment before it is essentially identical.

4. severe, effective：Symptom disappears or is relieved to the standard of " moderate " substantially.Effectively：Symptom is relieved to " compared with severe " It is below the mark.In vain：Symptom with treatment before it is essentially identical.

(2) ECG curative effect standard：

It is 1. effective：Electrocardiogram restores to " substantially normal " or reaches " normal ECG ".

2. effectively：S~T sections of reduction, with more than rise 0.05mv after treatment, but not up to normal level, mainly leading Connection negative T wave shoals (up to more than 25%) or T waves become upright from flat, chamber or intraventricular block improver.

It is 3. invalid：Electrocardiogram with treatment before it is essentially identical.

2.2.2 clinical test results are shown in Table 1.

1 clinical test results of table count

Group	Number of cases	It is effective	Effectively	In vain	Clinical obvious effective rate (%)	Total effective rate (%)
							Treatment group	80	57	16	7	71	91
Control group	80	35	24	21	44	74

Two groups of obvious effective rate curative effects compare in table 1, P<0.05, significant difference shows oral traditional Chinese medicine composition of the present invention The effect for the treatment of coronary heart disease is better than the therapy of conventional Chinese patent drug.

3rd, safety

After clinical observation result shows that 80 patients for the treatment of group take Chinese medicine composition of the present invention, blood routine, urine are normal Rule, liver function change without exception, have no adverse effects to renal function, no obvious toxic-side effects, take safe and reliable.To sum up institute It states, Chinese medicine composition of the present invention has the advantages that patients with coronary heart disease significant in efficacy, toxic side effect is small, and preparation process is simple, Stablize.This also further illustrates that Chinese medicine composition of the present invention has good market application foreground.

4th, model case

1st, Liu, female, 32 years old, housewife.First visit on the 10th in 2 months in 2006.Patient is at the beginning of 12 months 2005 due to debt Pressure is overworked, repeatedly palpitaition, uncomfortable in chest, is aggravated into one week.There is palpitaition, disease uncomfortable in chest in two years ago without apparent inducement in patient Shape does coherence check (particular exam project is unknown) in certain hospital and is diagnosed as coronary atherosclerotic heart disease, make a definite diagnosis with To take orally the drug therapies such as nifepine, symptom improvement always.Recurrence palpitaition, symptom uncomfortable in chest after fatigue in nearly one week, today are to ask to be System facilitates treatment, therefore enters here and seek medical advice.Patient this time falls ill, and spiritual, sleep is not good enough, and diet is poor, and two is just normal.Past medical history：Previously History of Coronary Heart Disease 2 years, protrusion of lumber intervertebral disc 3 years.Electrocardiogram report is shown：1. 2. imperfection right bundle branch block of sinus rhythm, 3. cardiac muscle Damage.Deny thering is hepatitis, tuberculosis etc. to infect medical history.Without drug and food hypersenstivity history, no wound, operation and blood transfusion history.Thick libngual fur It is yellow dark, soft and rapid pulse.It is dialectical:Spleen deficiency folder heat, the stagnation of the heart blood.Therapy:Invigorating the spleen is invigorated blood circulation, removing blood stasis and cleaning heat.The embodiment of the present invention 1 for oral administration carries What is supplied is used to treat the Chinese medicinal composition preparation of coronary heart disease, 2 times a day, 3 tablets each time；Mitigation uncomfortable in chest after taking medicine 3 weeks, it is in high spirits Turn, seizure frequency is reduced.Original side's plus-minus treatment 2 months is kept, above-mentioned symptom is alleviated significantly, and daily routines are unrestricted.

2nd, Lin, man, 21 years old, coach.First visit on the 17th in 2 months in 2007.Patient's pareordia recurrent exerbation angina 5 years aggravates 2 Zhou Yu.Patient's private prosecution pareordia recurrent exerbation angina since two thousand seven, it is after pressure is big more so, buccal to disappear sometimes in bored swollen sense It is pained slightly better.Nearly January carrys out angina pectoris attacks number and is increased, and companioned with headache is weak, and body heat is received less, and stool is dry, and urine is slightly yellow, State of an illness aggravation is with going to a doctor.Doctor trained in Western medicine is diagnosed as coronary disease and angina pectoris (instability mode).Indagation:Blood pressure 16.8/11.0kPa, spirit Not good enough, shortness of breath, 121 beats/min of heart rate, left holding material is unstable, and sweat is few, and simultaneous to see tongue dark purple, pale tongue is dark, and tongue is light greasy, deeptensepulse number.Card Type belongs to blood stasis stagnating heart meridian, type of deficiency of both the heart and spleen coronary heart disease.What the embodiment of the present invention 1 for oral administration provided is used to treat in coronary heart disease Drug composition preparation, 3 times a day, 2 tablets each time, medication feels that spirit increases after a week, and uncomfortable in chest, angina pectoris, shortness of breath improve, Period without significant discomfort, treats half a year, above-mentioned symptom complete incidence graph, V4, V5, V6 Lead ST segment, which has no, to be moved down.Follow-up after half a year, Patient tell it is even have pressure also do not occur before sensation of pain.

3rd, money, female, company's white collar, 38 years old, first visit on July 01 in 2008, pareordia was uncomfortable, pain uncomfortable in chest recurrent exerbation 4 Year.Present illness history:Patient before 4 years because of fatigue after occur precordial fullness pain, go to a doctor in Hainan hospital diagnosis be " coronary heart disease ", abide by Doctor's advice rule takes Isosorbide Mononitrate, often exacerbation of symptoms when fatigue, and taking nitroglycerine tablets can alleviate, and now originally be controlled for rooting It treats, seeks Chinese traditional treatment, therefore go to a doctor in our hospital's outpatient service.Inscribe disease:Occasionally there is swollen, pectoralgia uncomfortable in chest, tired postemphasis, shortness of breath is weak, mouth Dry, bitter taste is perspired, receive dormancy can, stool is dry, and urine is fine.Blood pressure 136/88mmHg after depressor is taken, denies that diabetes etc. are chronic Medical history；Deny drug and food hypersenstivity history.Tongue is dim, and yellow tongue fur is thin greasy, floating-rolling pulse.It is diagnosed as stagnation of QI-blood, it is strongly fragrant and change heat type hat Worry.The Chinese medicinal composition preparation for being used to treat coronary heart disease that the embodiment of the present invention 1 for oral administration provides, 3 times a day, 2 tablets each time；Even Take 3 weeks, after patient's private prosecution medication, occasionally have uncomfortable in chest, pain mitigates earlier above, and body has strength earlier above, and dry improves, receive dormancy can, greatly Just it does, it is small.Dimly red tongue, tongue is thin white, small and wiry pulse, earlier above effectively.Continue to take March, electrocardiogram is earlier above:Electrocardiogram is checked ST sections are restored normal.

4th, it is single certain, female, 71 years old, pensioner started pectoralgia occur before 4 years, duration autumn and winter season, aggravated suddenly, pain Pain is difficult to endure, left and right for 3 seconds, and mostly after heavy meal, breaking-out is frequent, and during episode, sublingual administration nitroglycerine tablets can Make pain relief.Main suit：Nearly one week frequent to break out, and the pectoralgia duration is grown than before, and there is tenderness sense in anterior pectorial region, draws a left side bitterly Shoulder, sees its tongue fur tongue picture, purplish tongue, and deeptensepulse is puckery and short.Electrocardiogram is prompted：ST sections move down, and T waves are inverted, completeness right bundle branch Block., heart vessel blockage stasis stagnant for the blood stasis of blood is examined, qi and blood is not smooth.Card belongs to heart arteries and veins and loses foster, cardiovascular stasis coronary heart disease.Take this orally The Chinese medicinal composition preparation for being used to treat coronary heart disease that inventive embodiments 1 provide, 3 times a day, 3 tablets each time；Two examine:Clothes medicine-feeding three Zhou Hou, subjective symptoms improve earlier above, continuously take three months, and patient symptom is obviously improved, and continue to take medicine-feeding to consolidate curative effect. Check electrocardio diagram：ST sections, T waves restored normal, follow-up 1 year is all right.

It should be noted that involved in claims of the present invention during numberical range, it is thus understood that each numberical range Any one numerical value can be selected between two endpoints and two endpoints, since the step method of use is identical with embodiment, It repeats in order to prevent, description of the invention preferred embodiment, although preferred embodiments of the present invention have been described, but ability Technical staff in domain once knows basic creative concept, then additional changes and modifications may be made to these embodiments. So appended claims are intended to be construed to include preferred embodiment and fall into all change and modification of the scope of the invention.

Obviously, various changes and modifications can be made to the invention without departing from essence of the invention by those skilled in the art God and range.In this way, if these modifications and changes of the present invention belongs to the range of the claims in the present invention and its equivalent technologies Within, then the present invention is also intended to include these modifications and variations.

Claims

1. a kind of Chinese medicine composition for being used to treat coronary heart disease, which is characterized in that the Chinese medicine composition includes following parts by weight Several bulk pharmaceutical chemicals：

20~45 parts of Radix Astragali, 6~12 parts of cassia twig, 15~30 parts of hawthorn, 10~30 parts of Radix Salviae Miltiorrhizae, 15~40 parts of Caulis Spatholobi, rhizoma alismatis 10 ~20 parts, 10~35 parts of Radix Angelicae Sinensis, 15~20 parts of dried orange peel, 15~20 parts of campanulaceae, 5~20 parts of oriental wormwood, 20~45 parts of kuh-seng, the coptis 3 ~15 parts, 12~40 parts of spina date seed.

2. the Chinese medicine composition according to claim 1 for being used to treat coronary heart disease, which is characterized in that the Chinese medicine composition Include the bulk pharmaceutical chemicals of following parts by weight：

20~35 parts of Radix Astragali, 6~9 parts of cassia twig, 15~25 parts of hawthorn, 10~20 parts of Radix Salviae Miltiorrhizae, 15~30 parts of Caulis Spatholobi, rhizoma alismatis 10~ 20 parts, 10~25 parts of Radix Angelicae Sinensis, 15~20 parts of dried orange peel, 15~20 parts of campanulaceae, 5~15 parts of oriental wormwood, 20~35 parts of kuh-seng, the coptis 3~ 10 parts, 12~30 parts of spina date seed.

3. the preparation method of the Chinese medicine composition according to claim 1 for being used to treat coronary heart disease, which is characterized in that including Following steps：

S1：20~45 parts of Radix Astragali, 6~12 parts of cassia twig, 15~30 parts of hawthorn, 10~30 parts of Radix Salviae Miltiorrhizae, chicken are weighed according to parts by weight 15~40 parts of blood rattan, 10~20 parts of rhizoma alismatis, 10~35 parts of Radix Angelicae Sinensis, 15~20 parts of dried orange peel, 15~20 parts of campanulaceae, 5~20 parts of oriental wormwood, 20~45 parts of kuh-seng, 3~15 parts of the coptis, 12~40 parts of spina date seed are spare；

S2：Each bulk pharmaceutical chemicals are mixed, is charged with and is equivalent to each 4~8 times of ethyl alcohol measured of bulk pharmaceutical chemicals total weight, immersion 1~ 2.0h, heating extraction 2~4 times later, 1~2.0h, merges extracting solution every time；Then 100~150 mesh filter, then through shutting off point Son amount for 5000~12000 ultrafiltration column carry out ultrafiltration, ultrafiltrate be concentrated under reduced pressure into relative density for 65~75 DEG C when 1.2~ 1.25 medicinal extract is stood, and obtains component ɑ；

S4：Component ɑ and component β is merged, is filtered, liquor strength is then concentrated under reduced pressure into as 1.0~1.2g/mL, is inhaled through macropore Attached resin column carries out polishing purification, obtains Chinese medical extract, the extracting solution is conventionally made pharmaceutically acceptable Pharmaceutical preparation.

4. the preparation method of the Chinese medicine composition according to claim 3 for being used to treat coronary heart disease, which is characterized in that described The pharmaceutical dosage form of oral drug preparation is tablet, capsule, granule, Disket or pill.

5. the preparation method of the Chinese medicine composition according to claim 3 for being used to treat coronary heart disease, which is characterized in that S4 In, the detailed process of polishing purification is as follows：

Liquid after reduced pressure is adsorbed through large pore resin absorption column, with the distillation water elution of 8~12 times of resin column volumes, then With the anhydrous ethanol elution of 4~6 times of resin column volumes, ethanol eluate is collected, solvent is removed, obtains Chinese medical extract.

6. the preparation method of the Chinese medicine composition according to claim 1 for being used to treat coronary heart disease, which is characterized in that including Following steps：

Step 1：20~45 parts of Radix Astragali is weighed according to parts by weight, 6~12 parts of cassia twig, 15~30 parts of hawthorn, 10~30 parts of Radix Salviae Miltiorrhizae, 15~40 parts of Caulis Spatholobi, 10~20 parts of rhizoma alismatis, 10~35 parts of Radix Angelicae Sinensis, 15~20 parts of dried orange peel, 15~20 parts of campanulaceae, oriental wormwood 5~20 Part, 20~45 parts of kuh-seng, 3~15 parts of the coptis, 12~40 parts of spina date seed are spare；

Step 2：Each bulk pharmaceutical chemicals are ground into particle, soak 1~2.5h, soaked bulk pharmaceutical chemicals are added water to cook 2~4 It is secondary, the water of 8~10 times of amounts of bulk pharmaceutical chemicals is added up for the first time, 1.5~2h is decocted, takes decocting liquid, is filtered；3~5 times of amounts of raw material are added up later Water, decoct 1~2h, take the mixing of 2~4 decocting liquids, filtration obtains filtrate；

Step 3：Relative density is 1.1~1.2 concentrate when concentrating filtrate to 70~80 DEG C, sets to 0~5 DEG C of low temperature colds Tibetan 20~for 24 hours；

Step 4：Add diatomite, filtering, filtrate decompression concentration into the refrigeration liquid that step 3 obtains, and be dried to powder, then will Pharmaceutically acceptable pharmaceutical preparation is conventionally made in powder.

7. the preparation method of the Chinese medicine composition according to claim 6 for being used to treat coronary heart disease, which is characterized in that described The pharmaceutical dosage form of pharmaceutical preparation is tablet, capsule, granule, Disket or pill.