CN104689241A

CN104689241A - Medicine for treating Qi-stagnation and blood stasis type coronary heart disease and preparation method thereof

Info

Publication number: CN104689241A
Application number: CN201510118406.4A
Authority: CN
Inventors: 付连进; 石洪柱; 张宁
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-03-18
Filing date: 2015-03-18
Publication date: 2015-06-10

Abstract

The invention discloses a medicine for treating a Qi-stagnation and blood stasis type coronary heart disease and preparation method thereof. The medicine comprises various raw material medicinal materials: fructus evodiae, fructus aurantii, salvia miltiorrhiza, lepidogrammitis rostrata, safflower carthamus, delphinium brunnonianum royle, platycodon grandiflorum, radix angelicae tuhuo, fructus piperis longi, iris halophila pall., agilawood, fissistigma oldhamii, radix paeoniae alba, stephania longa, agilawood, carcuma longa, angelica, trogopterus dung, bryoniifolia, rhizoma cyperi, tortoise shell, trigone, tribulus terrestris, zanthoxylum rhetsoides, folium apocyni veneti, fushen, rhizoma acori graminei, raphanus sativus l., allium macrostemon, lyonia, radix sophorae flavescentis, bombyx batryticatus, fructus ziziphi jujubae, morina chinensis and root of montane baliospermum. The medicine provided by the invention has the effects of promoting blood circulation to remove blood stasis, is mainly used for treating the Qi-stagnation and blood stasis type coronary heart disease, and has the advantages of being fast to take effect, high in effective rate, definite in curative effect, short in treatment course, low in price, and is free from toxic and side effects.

Description

A kind ofly treat medicine of qi stagnation and blood stasis type coronary heart disease and preparation method thereof

Technical field

The present invention relates to technical field of medicine, particularly a kind ofly treat medicine of qi stagnation and blood stasis type coronary heart disease and preparation method thereof.

Background technology

Namely coronary heart disease be that coronary atherosclerotic heart disease is coronary artery generation atherosclerotic lesion and causes lumen of vessels stenosis or occlusion, causes myocardial ischemia, anoxia or downright bad and heart disease that is that cause, be usually called as " coronary heart disease ".But the scope of coronary heart disease may be more extensive, also comprises inflammation, thromboembolism etc. and cause luminal stenosis or obturation.

The risk factor of incidence of coronary heart disease: comprise changeable risk factor and unmodifiable risk factor.Changeable risk factor has: hypertension, dyslipidemia (T-CHOL is too high or low-density lipoprotein cholesterol is too high, triglyceride is too high, HDL-C too low), overweight/obesity, hyperglycemia/diabetes, bad life style comprises smoking, unreasonable meals (higher fatty acid, hypercholesterolemia, high heat etc.), lacks physical exertion, excessive consumption of alcohol, and socio-psychological factors.Unmodifiable risk factor has: sex, age, family history.In addition, relevant with infection, as cytomegalovirus, Chlamydia pneumoniae, helicobacter pylori etc.

In motherland's medical literature, precordial pain with cold limbs, angina pectoris, the obstruction of heart-QI, the coronary heart disease of the thoracic obstruction etc. and modern medicine, angina pectoris, the site of pathological change of myocardial infarction, the character of symptom and performance, comprise radiation position and serious prognosis etc. have in various degree coincide, they may be all the performance of cardiac disorder, the above two belong to anginal performance in coronary heart disease, rear both may with cardiac dilatation, heart failure is related, but any one name of disease wherein, a upper equal sign can not be drawn simply, utterly with coronary heart disease.Primary disease "Nei Jing" claims " angina pectoris ", and its sick position has been eternal final conclusion at the heart, its secondary careful pathogenesis in detail.

Analyze the cause of disease of coronary heart disease, mostly be precordial pain with cold limbs, angina pectoris, the obstruction of heart-QI, the thoracic obstruction etc., therefore distinguish that its clinical syndrome is divided into: 1, heart-yang deficiency, stagnation of QI causing phlegm retention mechanism of qi: show as uncomfortable in chest, headache, cardiopalmus, breathe hard, pale complexion or dim stagnant, the tender white and moist fur of cold extremities with aversion to cold, spontaneous perspiration, clear urine in large amounts, soft stools, enlarged tongue, moderate pulse sliding or knot generation.2, the deficient type of the heart-yin, blockage of qi mechanism by phlegm: show as cardiopalmus, pained, feel suffocated, xerostomia, tinnitus, dizzy, night sweat, night sleep peaceful, the light red white and thin fur of frequent urination at night, waist soreness, tongue or no fur, thready and rapid pulse and short or thin wet and tie.3, cold coagulation heart arteries and veins type: soldier so has an excruciating pain in the chest, cold physique, cold weather or meet cold wind then pained easy outbreak or aggravation, very then hands and feet being not warm, and cold sweat goes out, cardiopalmus of breathing hard, chest pain radiating to the back, backache radiating to the heart, tense pulse, white and thin fur.4, qi stagnation and blood stasis type, front pain, uncomfortable in chest, cardiopalmus, breathes hard.To hold concurrently disease: spontaneous perspiration, dynamic then more so, aversion to cold and cold limbs, tired, light red tongue is fat, tongue in vain, deep-thready pulse; 5, pathogenic fire accumulation of heat type: causalgia in the heart, xerostomia, irritated, rough, expectorant is thick, or has heating, constipation, red tongue, yellow fur or rough, rapid pulse or sliding number.6, stagnation of QI ambition type: ambition is full vexed, and dull pain is a burst of, migratory pain, time for heaving a deep sigh, meet feelings and freely then do not bring out, aggravate, maybe can have wrist concurrently swollen, obtain heating installation, the arrow gas then disease such as easypro, thin fur or thin greasy, thready and stringy pulse.7, expectorant turbid impatency type: the different diseases such as phlegm retention, expectorant are turbid, phlegm-fire, wind-phlegm can be divided into.Phlegm retention person, uncomfortable in chest heavy and pained gently, meet the cloudy day and easily do, expectoration, tongue is greasy or whiten in vain, rolling pulse; Hold concurrently wet person, then visible mouth glues, and feels sick, indigestion and loss of appetite, asthenia, or the just disease such as soft.The turbid person of expectorant, uncomfortable in chest and double pained time do, expectorant glues the white greasy band of tongue to be done, or yellowish greasy, if expectorant is thick, color or Huang, defecate partially dry, greasy fur or dry, or yellow greasy, be then that expectorant is warm.Phlegm-fire person, uncomfortable in chest, make causalgia during ambition, the yellow stiff of expectorant, vexed, xerostomia, large dry stool or secret, yellow and greasy fur, slippery and rapid pulse.Wind-phlegm person, time uncomfortable in chest, pain, and is shown in tongue hemiplegia, dizzy, and brothers tremble the disease of numbness, greasy fur, stringy and rolling pulse.8, Yu Xue Bi closed form: ambition pain is more acute, if thorn is as strand, localized pain, with uncomfortable in chest, does not with the passing of time heal, or can be caused ambition severe pain by rage.Thin fur, tongue are dark red, purple is dark or have ecchymosis, or Sublingual blood vessels are livid purple, stringy and hesitant pulse or knot generation.9, deficiency of heart-QI type: a burst of dull pain in ambition, sensation of oppression over the chest with shortness of breath, dynamic then pant, cardiopalmus and flurried, fatigue and weakness, or lazy speech, pale complexion, or easily sweating, light red tongue is fat, has indentation, thin fur, deficient and thready pulse slow or knot generation.

Current treatment coronary heart disease mainly comprises the following aspects: 1. living habit changes: smoking cessation limit wine, low-fat low-salt diet, and suitable physical training, controls body weight etc.; 2. Drug therapy: antithrombotic (antiplatelet, anticoagulant), alleviates myocardium keto consumption (beta-blocker), allevating angina pectoris (nitrate esters), adjusts fat stabilize plaque (Statins fat regulation medicine); 3. myocardial revascularization treatment: comprise interventional therapy (intravascular balloon expansion plasty and Stent) and surgery coronary artery bypass grafting.Drug therapy is the basis of all treatments.Get involved and also will adhere to long-term standard medication therapy after surgical operation therapy.

But the utilization therapeutic effect of Western medicine is not very desirable, and somewhat expensive, can have side effects, easily recur patient, easily produce the shortcoming of drug dependence.

Summary of the invention

Technical problem to be solved by this invention is, there is provided a kind of and treat medicine of qi stagnation and blood stasis type coronary heart disease and preparation method thereof, the present invention has effect of blood circulation promoting and blood stasis dispelling, cure mainly qi stagnation and blood stasis type coronary heart disease, have rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, the advantages such as price is low.

In order to solve the problems of the technologies described above, the invention provides a kind of medicine for the treatment of qi stagnation and blood stasis type coronary heart disease, wherein, following raw medicinal material is comprised: Fructus Evodiae, Fructus Aurantii, Radix Salviae Miltiorrhizae, dominoes Herba pteridii latiusculi, Flos Carthami, Delphinium brunonianum Royle, Radix Platycodonis, Radix Angelicae Pubescentis, Fructus Piperis Longi, alkali ground Chinese small iris, Lignum Aquilariae Resinatum, Radix Fissistigmatis Oldhamii, the Radix Paeoniae Alba, Herba Stephaniae Longae, Rhizoma Curcumae Longae, Radix Angelicae Sinensis, Oletum Trogopterori, Caulis et folium vitis thunbergii, Rhizoma Cyperi, Carapax Et Plastrum Testudinis, Rhizoma Sparganii, Fructus Tribuli, Herba Zanthoxyli Myriacanthi, Folium Apocyni Veneti, Poria cum Radix Pini, Rhizoma Acori Graminei, Folium Raphani, Bulbus Allii Macrostemonis, Ramulus et folium lyoniae ovalifoliae (Littlefruit Lyonia), Radix Sophorae Flavescentis, Bombyx Batryticatus, Fructus Jujubae, Herba Morinae chinensis and Radix Merremiae hungaiensis.

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can be preferably: Fructus Evodiae 10 ~ 25 parts, Fructus Aurantii 12 ~ 28 parts, Radix Salviae Miltiorrhizae 10 ~ 35 parts, dominoes Herba pteridii latiusculi 11 ~ 21 parts, 14 ~ 38 parts, Flos Carthami, Delphinium brunonianum Royle 13 ~ 34 parts, Radix Platycodonis 12 ~ 34 parts, Radix Angelicae Pubescentis 12 ~ 23 parts, Fructus Piperis Longi 14 ~ 25 parts, alkali ground Chinese small iris 10 ~ 20 parts, Lignum Aquilariae Resinatum 11 ~ 27 parts, Radix Fissistigmatis Oldhamii 13 ~ 36 parts, the Radix Paeoniae Alba 14 ~ 31 parts, Herba Stephaniae Longae 13 ~ 36 parts, 11 ~ 20 parts, Rhizoma Curcumae Longae, Radix Angelicae Sinensis 14 ~ 31 parts, Oletum Trogopterori 13 ~ 37 parts, Caulis et folium vitis thunbergii 11 ~ 35 parts, Rhizoma Cyperi 10 ~ 24 parts, Carapax Et Plastrum Testudinis 11 ~ 28 parts, Rhizoma Sparganii 14 ~ 36 parts, Fructus Tribuli 11 ~ 26 parts, Herba Zanthoxyli Myriacanthi 13 ~ 37 parts, Folium Apocyni Veneti 14 ~ 28 parts, Poria cum Radix Pini 12 ~ 24 parts, Rhizoma Acori Graminei 10 ~ 36 parts, Folium Raphani 10 ~ 25 parts, Bulbus Allii Macrostemonis 14 ~ 28 parts, Ramulus et folium lyoniae ovalifoliae (Littlefruit Lyonia) 12 ~ 31 parts, Radix Sophorae Flavescentis 12 ~ 26 parts, Bombyx Batryticatus 15 ~ 27 parts, 10 ~ 30 parts, Fructus Jujubae, Herba Morinae chinensis 12 ~ 22 parts and Radix Merremiae hungaiensis 14 ~ 32 parts.

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Fructus Evodiae 12 ~ 22 parts, Fructus Aurantii 14 ~ 26 parts, Radix Salviae Miltiorrhizae 11 ~ 34 parts, dominoes Herba pteridii latiusculi 13 ~ 20 parts, 15 ~ 36 parts, Flos Carthami, Delphinium brunonianum Royle 15 ~ 32 parts, Radix Platycodonis 14 ~ 33 parts, Radix Angelicae Pubescentis 12 ~ 22 parts, Fructus Piperis Longi 15 ~ 25 parts, alkali ground Chinese small iris 13 ~ 20 parts, Lignum Aquilariae Resinatum 13 ~ 26 parts, Radix Fissistigmatis Oldhamii 14 ~ 35 parts, the Radix Paeoniae Alba 15 ~ 30 parts, Herba Stephaniae Longae 15 ~ 35 parts, 12 ~ 20 parts, Rhizoma Curcumae Longae, Radix Angelicae Sinensis 15 ~ 30 parts, Oletum Trogopterori 14 ~ 36 parts, Caulis et folium vitis thunbergii 12 ~ 34 parts, Rhizoma Cyperi 11 ~ 23 parts, Carapax Et Plastrum Testudinis 12 ~ 26 parts, Rhizoma Sparganii 15 ~ 35 parts, Fructus Tribuli 13 ~ 24 parts, Herba Zanthoxyli Myriacanthi 14 ~ 36 parts, Folium Apocyni Veneti 15 ~ 26 parts, Poria cum Radix Pini 14 ~ 22 parts, Rhizoma Acori Graminei 12 ~ 34 parts, Folium Raphani 11 ~ 23 parts, Bulbus Allii Macrostemonis 15 ~ 25 parts, Ramulus et folium lyoniae ovalifoliae (Littlefruit Lyonia) 15 ~ 30 parts, Radix Sophorae Flavescentis 14 ~ 24 parts, Bombyx Batryticatus 15 ~ 25 parts, 12 ~ 30 parts, Fructus Jujubae, Herba Morinae chinensis 14 ~ 20 parts and Radix Merremiae hungaiensis 15 ~ 30 parts.

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Fructus Evodiae 15 parts, Fructus Aurantii 20 parts, Radix Salviae Miltiorrhizae 32 parts, dominoes Herba pteridii latiusculi 18 parts, 35 parts, Flos Carthami, Delphinium brunonianum Royle 30 parts, Radix Platycodonis 22 parts, Radix Angelicae Pubescentis 20 parts, Fructus Piperis Longi 20 parts, alkali ground Chinese small iris 15 parts, Lignum Aquilariae Resinatum 25 parts, Radix Fissistigmatis Oldhamii 32 parts, the Radix Paeoniae Alba 30 parts, Herba Stephaniae Longae 34 parts, 16 parts, Rhizoma Curcumae Longae, Radix Angelicae Sinensis 28 parts, Oletum Trogopterori 35 parts, Caulis et folium vitis thunbergii 33 parts, Rhizoma Cyperi 22 parts, Carapax Et Plastrum Testudinis 24 parts, Rhizoma Sparganii 32 parts, Fructus Tribuli 20 parts, Herba Zanthoxyli Myriacanthi 35 parts, Folium Apocyni Veneti 24 parts, Poria cum Radix Pini 20 parts, Rhizoma Acori Graminei 34 parts, Folium Raphani 15 parts, Bulbus Allii Macrostemonis 22 parts, Ramulus et folium lyoniae ovalifoliae (Littlefruit Lyonia) 30 parts, Radix Sophorae Flavescentis 20 parts, Bombyx Batryticatus 25 parts, 30 parts, Fructus Jujubae, Herba Morinae chinensis 16 parts and Radix Merremiae hungaiensis 25 parts.

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Fructus Evodiae 22 parts, Fructus Aurantii 25 parts, Radix Salviae Miltiorrhizae 34 parts, dominoes Herba pteridii latiusculi 20 parts, 35 parts, Flos Carthami, Delphinium brunonianum Royle 30 parts, Radix Platycodonis 31 parts, Radix Angelicae Pubescentis 14 parts, Fructus Piperis Longi 23 parts, alkali ground Chinese small iris 20 parts, Lignum Aquilariae Resinatum 15 parts, Radix Fissistigmatis Oldhamii 35 parts, the Radix Paeoniae Alba 24 parts, Herba Stephaniae Longae 33 parts, 16 parts, Rhizoma Curcumae Longae, Radix Angelicae Sinensis 30 parts, Oletum Trogopterori 34 parts, Caulis et folium vitis thunbergii 32 parts, Rhizoma Cyperi 22 parts, Carapax Et Plastrum Testudinis 24 parts, Rhizoma Sparganii 35 parts, Fructus Tribuli 20 parts, Herba Zanthoxyli Myriacanthi 33 parts, Folium Apocyni Veneti 25 parts, Poria cum Radix Pini 20 parts, Rhizoma Acori Graminei 34 parts, Folium Raphani 22 parts, Bulbus Allii Macrostemonis 25 parts, Ramulus et folium lyoniae ovalifoliae (Littlefruit Lyonia) 30 parts, Radix Sophorae Flavescentis 21 parts, Bombyx Batryticatus 22 parts, 30 parts, Fructus Jujubae, Herba Morinae chinensis 15 parts and Radix Merremiae hungaiensis 26 parts.

Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Fructus Evodiae 12 parts, Fructus Aurantii 24 parts, Radix Salviae Miltiorrhizae 33 parts, dominoes Herba pteridii latiusculi 20 parts, 35 parts, Flos Carthami, Delphinium brunonianum Royle 32 parts, Radix Platycodonis 23 parts, Radix Angelicae Pubescentis 20 parts, Fructus Piperis Longi 24 parts, alkali ground Chinese small iris 20 parts, Lignum Aquilariae Resinatum 25 parts, Radix Fissistigmatis Oldhamii 33 parts, the Radix Paeoniae Alba 26 parts, Herba Stephaniae Longae 34 parts, 18 parts, Rhizoma Curcumae Longae, Radix Angelicae Sinensis 28 parts, Oletum Trogopterori 35 parts, Caulis et folium vitis thunbergii 32 parts, Rhizoma Cyperi 20 parts, Carapax Et Plastrum Testudinis 23 parts, Rhizoma Sparganii 34 parts, Fructus Tribuli 21 parts, Herba Zanthoxyli Myriacanthi 35 parts, Folium Apocyni Veneti 25 parts, Poria cum Radix Pini 20 parts, Rhizoma Acori Graminei 33 parts, Folium Raphani 20 parts, Bulbus Allii Macrostemonis 18 parts, Ramulus et folium lyoniae ovalifoliae (Littlefruit Lyonia) 24 parts, Radix Sophorae Flavescentis 16 parts, Bombyx Batryticatus 22 parts, 28 parts, Fructus Jujubae, Herba Morinae chinensis 20 parts and Radix Merremiae hungaiensis 30 parts.

Wherein, when the dosage form of described medicine is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 85% ~ 95%, reflux 4 ~ 6 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 ~ 4 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 3 hour, pulverize, sieve, obtain 400 order ~ 500 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.2 times, 0.15 ~ 0.3 times of lactose, the starch of 0.2 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.025 ~ 0.04 times of magnesium stearate, granulate, tabletting, makes.

Wherein, when the dosage form of described medicine is oral liquid, its preparation method comprises the following steps:

The first step, by Delphinium brunonianum Royle, Radix Platycodonis, Radix Angelicae Pubescentis, Fructus Piperis Longi, alkali ground Chinese small iris, Lignum Aquilariae Resinatum, Radix Fissistigmatis Oldhamii, the Radix Paeoniae Alba, Herba Stephaniae Longae, Rhizoma Curcumae Longae, Radix Angelicae Sinensis, Oletum Trogopterori with Caulis et folium vitis thunbergii mixing, add relative to mixture 6 ~ 8 times amount determining alcohol be 90% ~ 95% alcohol reflux 2 ~ 3 times, each 3 ~ 5 hours, filter respectively, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.37 ~ 1.39, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 ~ 7 times of water gagings, boils 4 ~ 6 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.32 ~ 1.36;

3rd step, the described mastic mixing that the first step, second step are obtained, 70 DEG C ~ 80 DEG C reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 80%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 24 ~ 48 hours, and refrigerated storage temperature is 3 DEG C ~ 6 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.2 ~ 0.35; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.003 ~ 0.005; The time of described heat treated is 70 ~ 90 minutes, and temperature is 150 DEG C ~ 180 DEG C;

6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described medicine oral liquid finished product.

Wherein, when the dosage form of described medicine is granule, its preparation method comprises the following steps:

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 4 ~ 8 times, mixture is the ethanol of 85% ~ 95%, be heated to boiling reflux 3 ~ 5 hours, filter, adopt percolation with the speed of 1 ~ 2ml per minute slowly percolation, collect percolate, when being evaporated to 50 ~ 60 DEG C subsequently under vacuum 0.06 ~ 0.09Mpa, relative density is the mastic of 1.04 ~ 1.10, spraying dry, the inlet temperature 160 ~ 175 DEG C of spray dryer, leaving air temp 80 ~ 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.2 ~ 0.4 times and 0.1 ~ 0.2 times in the dried cream powder obtained, makes granule, in 40 ~ 50 DEG C of dryings, obtains granule.

The invention has the beneficial effects as follows: the present invention has effect of blood circulation promoting and blood stasis dispelling, cure mainly qi stagnation and blood stasis type coronary heart disease, have rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, the advantages such as price is low.

Detailed description of the invention

The invention provides a kind of medicine for the treatment of qi stagnation and blood stasis type coronary heart disease, wherein, following raw medicinal material is comprised: Fructus Evodiae, Fructus Aurantii, Radix Salviae Miltiorrhizae, dominoes Herba pteridii latiusculi, Flos Carthami, Delphinium brunonianum Royle, Radix Platycodonis, Radix Angelicae Pubescentis, Fructus Piperis Longi, alkali ground Chinese small iris, Lignum Aquilariae Resinatum, Radix Fissistigmatis Oldhamii, the Radix Paeoniae Alba, Herba Stephaniae Longae, Rhizoma Curcumae Longae, Radix Angelicae Sinensis, Oletum Trogopterori, Caulis et folium vitis thunbergii, Rhizoma Cyperi, Carapax Et Plastrum Testudinis, Rhizoma Sparganii, Fructus Tribuli, Herba Zanthoxyli Myriacanthi, Folium Apocyni Veneti, Poria cum Radix Pini, Rhizoma Acori Graminei, Folium Raphani, Bulbus Allii Macrostemonis, Ramulus et folium lyoniae ovalifoliae (Littlefruit Lyonia), Radix Sophorae Flavescentis, Bombyx Batryticatus, Fructus Jujubae, Herba Morinae chinensis and Radix Merremiae hungaiensis.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Fructus Evodiae: come from " herbal classic ": " main warming the middle warmer and descending qi, pain relieving, cough with dyspnea cold and heat, dehumidifying, arthralgia due to stagnation of blood, by ailment said due to cold or exposure, loosing the interspaces of skin and muscles." Compendium of Material Medica: " dissipating depression of QIization is stagnant, controls acid regurgitation, and cloudy sputum of fainting is had a headache, insidious stomachache, hernia dysentery, mouthpiece's aphtha." its bitter in the mouth hot in nature trembles with fear, and has the merit of heat radiation pain relieving, stopping nausea and vomiting by lowering the adverse flow of QI, is used for the treatment of that liver insufficiency of stomach is trembled with fear, the disease such as headache caused by cloudy turbid superinverse or stomach wrist pain.Can warming middle-JIAO, pain relieving, regulates the flow of vital energy, dampness, and stopping vomiting is against acid regurgitation, and headache due to JUE YIN disorder, the coldness of ZANG-organ is vomited and diarrhoea, abdominal distention, abdominal pain during menstruation, Diarrhoea, vascular hypertension, beriberi, hernia, aphthous ulcer, toothache, eczema, impetigo.

Radix Salviae Miltiorrhizae: bitter in the mouth, cold in nature, enters the heart, Liver Channel, has the effect of blood circulation promoting and blood stasis dispelling, promoting tissue regeneration by removing blood stasis, removing heat from blood mind calming, be mainly used in the ambition of stagnation of QI and blood, the twinge of the breast side of body, sensation of oppression over the chest with shortness of breath, abdominal distention; The menoxenia of women's disharmony between QI and blood, dysmenorrhoea amenorrhea; Stagnation of QI-blood, the symptoms such as trusted subordinate's pain, Radix Salviae Miltiorrhizae can reduce as interior fat and testis peripheral adipose, alleviates insulin secretion and glycometabolic Random early Detection.Strengthen myocardial contraction, improve cardiac function, do not increase myocardial oxygen consumption.Coronary artery dilating, increases myocardial flow; Expansion peripheral blood vessel, blood flow increases; Cerebral blood flow declines, and improves plasmin activity; Extend bleeding and cotting time; Anticoagulant; Improve hemorheological properties (blood viscosity reduction, erythrocyte electrophoretic time are shortened).

Flos Carthami: warm in nature, acrid in the mouth, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury.

Radix Platycodonis: bitter in the mouth, pungent, property is put down.Return lung meridian.There is lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, effect of filling blood, mending five kinds of over strain, foster the spirit of nobility.Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus." herbal classic " is said: " main chest and hypochondrium as lancination, abdominal distention, borborygmus are faint, gas of throbbing with fear in terror "." Japan hanako materia medica " is said: " mend five kinds of over strain, foster the spirit of nobility, evil removing wards off temperature, tonify deficiency expectorant for all gas lower, only cramp caused by acute vomiting and diarrhea, trusted subordinate's distending pain, broken lump in the abdomen, and evacuation of pus of nourishing blood, mends internal hemorrhage due to trauma and sore throat ".Modern pharmacological research shows, Radix Platycodonis has and eliminates the phlegm and antitussive effect; Hypoglycemic activity; Suppress gastric secretion and antiulcer action; Antiinflammatory action; Calmness, analgesia and refrigeration function.

Fructus Piperis Longi: another name: Fructus Piperis Longi (Tang Materia Medica), Fructus Piperis Longi pears, Ah pears scold Ye (" Youyangzazu "), mulberry sage (Hou Ningji " medicine spectrum "), clam beach wormwood (" red refined "), Mus tail (" Chinese medicinal herbal ").Nature and flavor: pungent, heat.Gui Jing: return spleen channel, stomach warp, large intestine channel, lung meridian, urinary bladder channel, Liver Channel, kidney channel.1. " detailed outline ": " start with, Foot yangming Channel." 2. " Thunder God concocts property of medicine solution ": " enters lung, spleen, stomach, bladder four warp." 3. " book on Chinese herbal medicine is new again ": " enters liver,spleen,kidney three warp." function: warming spleen and stomach for dispelling cold, therapeutic method to keep the adverse QI flowing downwards pain relieving.Cure mainly: for coldness and pain in the epigastrium, vomit, have loose bowels, the toothache of migraine, nasal sinusitis, external treatment, coronary heart diseases and angina pectoris.Control trusted subordinate's cold type of pain, vomiting acid regurgitation, increased borborygmus and diarrhea, cold-dysentery, scrotal hernia, headache, nasal sinusitis, toothache.

Lignum Aquilariae Resinatum: pungent, bitter, temperature; Return spleen, stomach, kidney, lung meridian." Japan hanako materia medica ": " in tune, tonifying five ZANG-organs, nourishing essence and tonifying YANG, warm waist knee joint, uncharm gas.Ending tendon transfer, vomiting and diarrhoea, cold air, broken disease addiction, (controlling) cold wind is benumbed, and joint is not appointed, and wet wind skin is itched, cardiac and abdominal pain, diarrhea due to disorder of qi." Compendium of Material Medica: " control heat in the upper and cold in the lower, QI rising in reverse order is panted, and asthenia of the large intestine closes, urine qi stranguria, man's cold sperm.”

Rhizoma Cyperi: the pungent micro-hardship of nature and flavor is sweet, flat.Enter liver, tri-jiao channel.Compendium of Material Medica is said: " gas of Rhizoma Cyperi is flat and do not tremble with fear, fragrant and can alter, and how pungent its taste is can fall apart, and micro-hardship can be fallen, micro-sweet energy with "." Amplification on Materia Medica addendum ": " Rhizoma Cyperi, must soak with urine of baby boys, all vim and vigour medicines must with it, cause edema caused by disorder of QI and hemopoietic, the justice of this Yin grows while yang is generating is also." resolving depression of can regulating the flow of vital energy; Menstruction regulating and pain relieving; Antiabortive.Main distending pain over the hypochondrium; Mammary swelling is educated; Hernia pain; Menoxenia; Gastral cavity abdomen feeling of fullness pain; Belch acid regurgitation, vomiting and nausea; Abdominal pain during menstruation; Bleeding not during menses; Frequent fetal movement.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.Ethanol extraction does not affect epinephrine and acetylcholine to the effect of blood pressure, but can the effect of part blocks histamine.5% Rhizoma Cyperi fluid extract is to the isolated uterine of the animals such as Cavia porcellus, rabbit, cat and dog, and no matter oneself pregnant or unpregnancy, has inhibitory action, makes that its contractility weakens, muscular tension reduces.

The Radix Paeoniae Alba: bitter in the mouth, acid, cold nature, enters liver, spleen channel, joint venture of nourishing blood, easing the affected liver to relieve pain, and the effect of suppressing liver-YANG is mainly used in deficiecny of liver-YIN, the headache feeling of fullness in the head of excessive rising of liver-YANG, vertigo and tinnitus, irritable; Deficiency of liver-blood, battalion defends the menoxenia of inanition, metrorrhagia and metrostaxis; The dysmenorrhea of deficiency of the liver stasis dampness; Disharmony of nutrient QI with defensive QI, the cloudy outer inducing vomiting spontaneous sweating of battalion; The gastral cavity abdomen pain over the hypochondriac region of depression of liver-QI, dysentery is suffered from abdominal pain; Deficiency and exhaustion of liver-YIN, passages through which vital energy circulates loses the card such as carpopedal spasm pain of supporting, and paeoniflorin has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose.There are antithrombus formation and hepatoprotective effect, have inhibitory action to dysentery bacterium, Bacillus typhi, blood dissolubility streptococcus, Diplococcus pneumoniae, bacillus pyocyaneus, staphylococcus aureus.

Bulbus Allii Macrostemonis: acrid in the mouth, hardship, warm in nature; Gui Jing, lung, the heart, stomach, large intestine channel." Mingyi Bielu ": " be attributed to bone.Except cold and heat, anhydrate gas, warming middle-JIAO eliminating stagnation.Wind and cold edema in all skin ulcers, to be coated with it." supplement to the Herbal: " in tune, main chronic diarrhea is not recovered, normal evil person in large abdomen, but cooks it more." have and regulate the flow of vital energy, the chest stuffiness relieving, activate yang, eliminating stagnation, effect of intestinal stasis relieving.Cure mainly the thorough back of the body of obstruction of qi in the chest and cardialgia, breast gastral cavity painful abdominal mass is vexed, cough with asthma abundant expectoration, epigastric pain, heavy after letting out dysentery, leucorrhea, furuncle carbuncle.Bulbus Allii Macrostemonis water decoction has suppression to dysentery bacterium, staphylococcus aureus.Bulbus Allii Macrostemonis can obviously disturb hematoblastic arachidonic acid metabolic, suppresses its Cycloxygenase metabolic pathway, suppresses the synthesis of TXB2 and HHT.The pungent loose hardship of these product is fallen, temperature is logical slides profit, and kind loose YIN-cold is to stagnate, and what lead to breast sun closes knot, for controlling the key medicine of the thoracic obstruction.Control thoracic obstruction card caused by cold-phlegm retardance, hypofunction of YANG QI in chest, the pungent row hardship of these product is fallen, and has the merit of circulation of qi promoting intestinal stasis relieving, relieving distension pain relieving.

Rhizoma Curcumae Longae: acrid in the mouth, hardship, warm in nature, return liver, spleen channel, Compendium of Material Medica: " Rhizoma Curcumae Longae, time near with flat if Rhizoma Zingiberis shape person is for RHIZOMA WENYUJIN CONCISA, circle such as Cicadae abdomen shape person be Cicadae tripe Radix Curcumae, though and the ， Shu shape seemingly Radix Curcumae of dyeing that can soak, complexion is not yellow yet." " book on Chinese herbal medicine asks former ": " and Rhizoma Curcumae Longae, benefit fire is angry, this cremate gas of pungent temperature, and gas biochemistry then body fluid is capable of three YIN and three YANG; Clear person notes in lung, turbid person note in through, slip in sea, and blood is voluntarily, is the eliminating stagnation and doublely let out blood also of regulating the flow of vital energy." there is removing blood stasis circulation of qi promoting, effect of inducing menstruation to relieve menalgia.

Oletum Trogopterori: sweet, temperature.Promoting blood circulation to remove blood stasis, parch to black stops blooding.Have a pain for trusted subordinate's congestion, dysmenorrhea, blood stasis amenorrhea, puerperal abdominalgia with blood stasis; Parch to black controls metrostaxis; Traumatic injury is controlled in external, Serpentis, insect bite wound.It is logical that Oletum Trogopterori hardship lets out temperature, and " tonneau gaseous pulse ", " general rule is not bitterly.”

Carapax Et Plastrum Testudinis: salty, sweet, is slightly cold; Return liver, kidney, heart channel.Compendium of Material Medica: " reinforcing the heart, the kidney invigorating, to enrich blood, all with yin nourishing also ... see Carapax Et Plastrum Testudinis and lead all diseases, all genus deficiency of YIN blood is weak." nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, reinforcing the heart of nourishing blood.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, has a dizzy spell, stirring-up of pathogenic wind in the interior resulting from deficiency, and muscles and bones flaccidity is soft, has a guilty conscience forgetful.

Fructus Tribuli: " Mingyi Bielu ": " main health pruritus due to wind pathogen, headache, cough with dyspnea impairing the lung, consumptive lung disease, only tired, the therapeutic method to keep the adverse QI flowing downwards; Children's's head sore, the cloudy Huang of carbuncle, can rub powder." loose wind, improving eyesight, the therapeutic method to keep the adverse QI flowing downwards, promoting the circulation of blood.Control headache, itching over the body, conjunctival congestion swells nebula, fullness in the chest, cough with dyspnea, lump in the abdomen, and breast is difficult, carbuncle, scrofula.

Folium Apocyni Veneti: sweetness and bitterness is cool." Shaanxi Chinese herbal medicine ": " refrigerant pathogenic fire purging, heart tonifying diuresis, blood pressure lowering.Control heart disease, hypertension, neurasthenia, nephritis edema." relieve inflammation or internal heat, blood pressure lowering, heart tonifying, diuresis.Control heart disease, hypertension, neurasthenia, hepatitis abdominal distention, nephritis edema.

Rhizoma Acori Graminei: nature and flavor are pungent, bitter, temperature.GUIXIN, stomach warp.Can removing dampness whet the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae., keep silent a mouthful dysentery not hungry for gastral cavity painful abdominal mass, coma epilepsy, forgetful deafness.Regulate the flow of vital energy, invigorate blood circulation, loose wind, dries.Control epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury." not Lu " records it: " warming intestines and stomach, only normal urination, extremity arthralgia chiefly caused by damp pathogen, must not bend and stretch, children's's pyrexial malaria, and body accumulated heat is not understood, and can do to bathe soup for main deafness, carbuncle skin ulcer.

Radix Sophorae Flavescentis: the effect having anti-inflammation, all has inhibitory action to Propiobacterium, staphylococcus aureus, escherichia coli, can diuresis, antiallergic, ease pain, relieving asthma, eliminate the phlegm.Bitter in the mouth; Cold in nature.Return liver; Kidney; Large intestine; Small intestine meridian; Bladder; Heart channel; Urinary bladder channel.

Fructus Jujubae: sweet in the mouth, warm in nature, enter spleen, stomach warp.There is the effect of air making-up and spleen enlivening, nourishing blood to tranquillize the mind, harmonizing yingfen and weifen, the mitigation property of medicine, for weakness of the spleen and stomach, fatigue and asthenia, anorexia and loose stool, insufficiency of vital energy and blood, has a headache and fever, the cards such as sweating hot blast, Fructus Jujubae has the effect of muscle strength reinforcing, has and increases total serum protein and albuminous function.Cyclic adenosine monophosphate contained by Fructus Jujubae is the required composition of human body cell energy metabolism, can muscle strength reinforcing, allaying tiredness, blood vessel dilating, increase myocardial contraction, improve myocardial nutrition, to control cardiovascular system diseases have good effect; Fructus Jujubae has good therapeutic effect to diseases such as chronic hepatitis, liver cirrhosis, anemia, anaphylactoid purpura; Fructus Jujubae contains triterpenoid compound and cyclic adenosine monophosphate, has stronger anticancer, anti-allergic effects.Fructus Jujubae can moisten cardiopulmonary, cough-relieving, tonifying five ZANG-organs, it is deficient to control, except the intestines and stomach addiction gas, can also regulating the spleen and stomach support spleen, flat gastric qi, logical nine orifices, help 12 through etc.

Radix Merremiae hungaiensis: nature and flavor: pungent, tepor.Cure mainly: removing toxic substances anthelmintic, synthetism, dissipating blood stasis for subsidence of swelling.Control traumatic injury, fracture, ascariasis, icterohepatitis.

Folium Raphani: cure mainly: help digestion and quench the thirst, thermal detoxification of dispelling.Cure mainly fullness in the chest vexed, two sides of body are done swollen, and eliminate indigestion is stagnant, alcoholic intoxication.

Herba Stephaniae Longae: nature and flavor: micro-hardship, puckery is flat.Cure mainly: heat-clearing and toxic substances removing, inducing diuresis to remove edema.For pyelonephritis, cystitis, chronic nephritis, enteritis, dysentery, venom; Carbuncle furuncle infections is controlled in external, suppurative otitis media.

Poria cum Radix Pini: nature and flavor: sweet, flat.Cure mainly: mind tranquilizing and the heart calming.Be applicable to the disease such as severe palpitation, insomnia forgetfulness.

Delphinium brunonianum Royle: nature and flavor: bitter, puckery, cold.Cure mainly: removing pathogenic heat from blood and toxic substance from the body, dispelling wind for relieving itching.Cure mainly influenza, itchy skin eruption, the diseases such as venom.

Dominoes Herba pteridii latiusculi: nature and flavor: micro-bitter, sweet, flat.Nontoxic.Cure mainly: clearing away heat and promoting diuresis, relieving restlessness, lung heat clearing gas.Cure mainly and drench the drop difficulty in urination, heat syndrome cough, vexed.

Caulis et folium vitis thunbergii: nature and flavor: sour, sweet, puckery is flat.Cure mainly: heat-clearing and toxic substances removing, expelling wind and removing dampness.For hepatitis, appendicitis, mastitis, lung abscess, multiple abscess, rheumatic arthritis; Sore swollen toxin is controlled in external, otitis media, snake bite and insect sting.

Radix Fissistigmatis Oldhamii: nature and flavor: micro-pungent, temperature.Cure mainly: expelling wind and activating blood circulation, analgesia.Cure mainly sciatica, arthritis, traumatic injury.

Radix Angelicae Pubescentis: nature and flavor: pungent, bitter, tepor.Gui Jing: return kidney, urinary bladder channel.Cure mainly: expelling wind and removing dampness, numbness relieving and pain relieving.For anemofrigid-damp arthralgia, lumbocrural pain, few cloudy volt wind headache.

Rhizoma Sparganii: nature and flavor: pungent, bitter is flat.Gui Jing: return liver, spleen channel.Cure mainly: removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.For lump in the abdomen mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain.

Bombyx Batryticatus: nature and flavor: salty, pungent is flat.Gui Jing: return liver, lung, stomach warp.Cure mainly: expelling wind for relieving convulsion, dissipating phlegm and resolving masses.For convulsion with spasms, laryngopharynx swelling and pain, skin pruritus, submandibular lymph nodes is scorching, facial paralysis.

Radix Angelicae Sinensis: nature and flavor: sweet, acrid, warm.Gui Jing: return liver, the heart, spleen channel.Cure mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.

Alkali ground Chinese small iris: nature and flavor: sweet, light, cool.Cure mainly: heat-clearing and toxic substances removing, diuresis, hemostasis.

Herba Morinae chinensis: nature and flavor: sweet, bitter, temperature.Cure mainly: stomach invigorating, emetic, detumescence.Cure mainly the diseases such as stomachache.Sore, carbuncle and painful swelling is controlled in external.

Ramulus et folium lyoniae ovalifoliae (Littlefruit Lyonia): nature and flavor: sweet, sour is flat.Cure mainly: invigorating the spleen to arrest diarrhea, invigorate blood circulation, strong muscle.

Herba Zanthoxyli Myriacanthi: nature and flavor: pungent, micro-hardship, temperature.Cure mainly: expelling wind and removing dampness, promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain.Fructus Aurantii: nature and flavor: bitter, pungent, sour, temperature.Gui Jing: return spleen, stomach warp.

Embodiment 1 tablet

The manufacturing process of Tablets is: get Fructus Evodiae 150g, Fructus Aurantii 200g, Radix Salviae Miltiorrhizae 320g, dominoes Herba pteridii latiusculi 180g, Flos Carthami 350g, Delphinium brunonianum Royle 300g, Radix Platycodonis 220g, Radix Angelicae Pubescentis 200g, Fructus Piperis Longi 200g, alkali ground Chinese small iris 150g, Lignum Aquilariae Resinatum 250g, Radix Fissistigmatis Oldhamii 320g, Radix Paeoniae Alba 300g, Herba Stephaniae Longae 340g, Rhizoma Curcumae Longae 160g, Radix Angelicae Sinensis 280g, Oletum Trogopterori 350g, Caulis et folium vitis thunbergii 330g, Rhizoma Cyperi 220g, Carapax Et Plastrum Testudinis 240g, Rhizoma Sparganii 320g, Fructus Tribuli 200g, Herba Zanthoxyli Myriacanthi 350g, Folium Apocyni Veneti 240g, Poria cum Radix Pini 200g, Rhizoma Acori Graminei 340g, Folium Raphani 150g, Bulbus Allii Macrostemonis 220g, Ramulus et folium lyoniae ovalifoliae (Littlefruit Lyonia) 300g, Radix Sophorae Flavescentis 200g, Bombyx Batryticatus 250g, Fructus Jujubae 300g, Herba Morinae chinensis 160g and Radix Merremiae hungaiensis 250g,

The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 5 times is the ethanol of 95%, reflux 4 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 3 times again, reflux 3 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 500 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.2 times, 0.2 times of lactose, the starch of 0.3 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.027 times of magnesium stearate, granulate, tabletting, makes.

Embodiment 2 oral liquid

The manufacturing process of oral liquid of the present invention is: get Fructus Evodiae 220g, Fructus Aurantii 250g, Radix Salviae Miltiorrhizae 340g, dominoes Herba pteridii latiusculi 200g, Flos Carthami 350g, Delphinium brunonianum Royle 300g, Radix Platycodonis 310g, Radix Angelicae Pubescentis 140g, Fructus Piperis Longi 230g, alkali ground Chinese small iris 200g, Lignum Aquilariae Resinatum 150g, Radix Fissistigmatis Oldhamii 350g, Radix Paeoniae Alba 240g, Herba Stephaniae Longae 330g, Rhizoma Curcumae Longae 160g, Radix Angelicae Sinensis 300g, Oletum Trogopterori 340g, Caulis et folium vitis thunbergii 320g, Rhizoma Cyperi 220g, Carapax Et Plastrum Testudinis 240g, Rhizoma Sparganii 350g, Fructus Tribuli 200g, Herba Zanthoxyli Myriacanthi 330g, Folium Apocyni Veneti 250g, Poria cum Radix Pini 200g, Rhizoma Acori Graminei 340g, Folium Raphani 220g, Bulbus Allii Macrostemonis 250g, Ramulus et folium lyoniae ovalifoliae (Littlefruit Lyonia) 300g, Radix Sophorae Flavescentis 210g, Bombyx Batryticatus 220g, Fructus Jujubae 300g, Herba Morinae chinensis 150g and Radix Merremiae hungaiensis 260g,

The first step, by Delphinium brunonianum Royle, Radix Platycodonis, Radix Angelicae Pubescentis, Fructus Piperis Longi, alkali ground Chinese small iris, Lignum Aquilariae Resinatum, Radix Fissistigmatis Oldhamii, the Radix Paeoniae Alba, Herba Stephaniae Longae, Rhizoma Curcumae Longae, Radix Angelicae Sinensis, Oletum Trogopterori with Caulis et folium vitis thunbergii mixing, add relative to mixture 7 times amount determining alcohol be 90% alcohol reflux 3 times, each 5 hours, filter respectively, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.37, for subsequent use;

Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 6 times of water gagings, boils 5 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.35;

3rd step, the described mastic mixing that the first step, second step are obtained, 80 DEG C of reduced vacuum dryings, get dry extract powder;

4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 70%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 48 hours, and refrigerated storage temperature is 5 DEG C;

5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.004; The time of described heat treated is 80 minutes, and temperature is 160 DEG C;

Embodiment 3 granule

The manufacturing process of granule of the present invention is: get Fructus Evodiae 120g, Fructus Aurantii 240g, Radix Salviae Miltiorrhizae 330g, dominoes Herba pteridii latiusculi 200g, Flos Carthami 350g, Delphinium brunonianum Royle 320g, Radix Platycodonis 230g, Radix Angelicae Pubescentis 200g, Fructus Piperis Longi 240g, alkali ground Chinese small iris 200g, Lignum Aquilariae Resinatum 250g, Radix Fissistigmatis Oldhamii 330g, Radix Paeoniae Alba 260g, Herba Stephaniae Longae 340g, Rhizoma Curcumae Longae 180g, Radix Angelicae Sinensis 280g, Oletum Trogopterori 350g, Caulis et folium vitis thunbergii 320g, Rhizoma Cyperi 200g, Carapax Et Plastrum Testudinis 230g, Rhizoma Sparganii 340g, Fructus Tribuli 210g, Herba Zanthoxyli Myriacanthi 350g, Folium Apocyni Veneti 250g, Poria cum Radix Pini 200g, Rhizoma Acori Graminei 330g, Folium Raphani 200g, Bulbus Allii Macrostemonis 180g, Ramulus et folium lyoniae ovalifoliae (Littlefruit Lyonia) 240g, Radix Sophorae Flavescentis 160g, Bombyx Batryticatus 220g, Fructus Jujubae 280g, Herba Morinae chinensis 200g and Radix Merremiae hungaiensis 300g,

Step one: described raw medicinal material is mixed in described ratio, adding relative to the determining alcohol of 7 times, mixture is the ethanol of 90%, be heated to boiling reflux 5 hours, filter, adopt percolation with the speed of 2ml per minute slowly percolation, collect percolate, when being evaporated to 60 DEG C subsequently under vacuum 0.08Mpa, relative density is the mastic of 1.04, spraying dry, the inlet temperature 170 DEG C of spray dryer, leaving air temp 85 DEG C, be ground into powder subsequently, make dried cream powder;

Step 2: the dextrin adding cane sugar powder relative to dried cream powder quality 0.3 times and 0.15 times in the dried cream powder obtained, makes granule, in 45 DEG C of dryings, obtains granule.

Acute toxicity test: application NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 25g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; The tablet enema prepared by embodiments of the invention 1 is dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>28.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Clinical drug dosage of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage medicine of the present invention is 745 times of quantity.Therefore Acute toxicity of the present invention is low, clinical drug safety.

Long term toxicity test: by the Oral Liquid On Mice of the embodiment of the present invention 2 by 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: fetch and come from the court's period 308 in July ,-2012 in July, 2011 routine qi stagnation and blood stasis type patients with coronary heart disease, wherein man 161 example, female 147 example; 42 ~ 75 years old age, 60.7 ± 2.3 years old mean age, myocardial infarction 97 example, angina pectoris 112 example, arrhythmia, cardiac blood supply deficiency 99 example, all cases is all made a definite diagnosis through resting electrocardiogram, exercise stress electrocardiogram and 24 hr Ambulatory EKG Monitoring, CT, coronary angiography inspection.308 routine patients are divided into tablet in treatment group, oral liquid treatment group, liniment treatment group and matched group at random, and each experimental group 77 people, each experimental group is at age, sex difference not statistically significant.

Diagnostic criteria:

1, myocardial infarction: it is the evolution row current of injury occurring exception, lasting Q ripple or QS ripple and continue more than 1 day that Electrocardiographic certainty changes.

2, angina pectoris: angina pectoris, tranquillization electrograph is about more than half can be normal, leading based on R ripple during angina pectoris attacks, can occur that ST section level or sagging type force down, companion or without T ripple, smooth, two-way or be inverted, variant angina pectoris outbreak time visible ST section high, to have an electro-cardiogram if desired stress test, radionuclide myocardial development and coronarography.

3, arrhythmia, cardiac blood supply deficiency: comprise premature beat electrocardiogram, paroxysmal supraventricular tachycardia, atrial fibrillation, slow arrhythmia electrocardiogram, cardiac blood supply deficiency electrocardiogram.

Refer again to " Diagnostics of Chinese Medicine ", " TCM syndrome Differential Diagnosis ", primary symptom: the precordialgia, uncomfortable in chest, cardiopalmus, to breathe hard.To hold concurrently disease: spontaneous perspiration, dynamic then more so, aversion to cold and cold limbs, tired, light red tongue is fat, tongue in vain, deep-thready pulse.Hope according to the traditional Chinese medical science, hear, ask, cut and be diagnosed as qi stagnation and blood stasis type coronary heart disease further.

Therapeutic Method:

Tablet in treatment group: use the embodiment of the present invention 1 prepare tablet, every day 3 times, one time 1, within every 30 days, be a course for the treatment of;

Oral liquid treatment group: use oral liquid prepared by the embodiment of the present invention 2, every day 3 times, 30ml/ time every 30 days is a course for the treatment of;

Granules in Treating group: use the embodiment of the present invention 3 prepare granule, every day 3 times, every bag of 6g, one time 1 bag, within every 30 days, be a course for the treatment of.

Matched group: take TONGMAI KELI, every day 3 times, 10g/ time every 30 days is a course for the treatment of.

The standard of curative effect evaluation:

1, myocardial infarction:

Cure: normal ECG, without any clinical symptoms, follow the tracks of 3-7 and have no recurrence;

Effective: normal ECG, without any clinical symptoms, in 3 years, there is rebound phenomena;

Take a turn for the better: electrocardiogram takes a turn for the better, and symptom obviously alleviates;

Invalid: electrocardiogram is without change, but symptom alleviates.

2, angina pectoris:

Invalid: electrocardiogram is without change, but symptom alleviates.

3, arrhythmia, cardiac blood supply deficiency:

Invalid: electrocardiogram is without change, but symptom alleviates.

Therapeutic outcome:

See table 1 and table 2, as can be seen from Table 1, adopt Drug therapy qi stagnation and blood stasis type coronary heart disease of the present invention, relative to conventional medicament on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt Drug therapy qi stagnation and blood stasis type coronary heart disease of the present invention, relative to Western medicine, treatment the course for the treatment of on significantly shorten.

After each group of table 1 treats 4 courses for the treatment of respectively, Clinical efficacy comparison is routine

Group	Number of cases	Cure number	Effective number	Good revolution	Invalid number	Total effective rate (%)
							Tablet in treatment group	77	34	37	6	0	100％
Oral liquid treatment group	77	35	38	4	0	100％
							Granules in Treating treatment group	77	33	35	8	1	98.7％
Matched group	77	15	20	27	15	80.5％

Table 2 Four composition do not treat after 4 courses for the treatment of cure, effective and improvement number and time comparative example (%)

Group	Number of cases	1st course for the treatment of	2nd course for the treatment of	3rd course for the treatment of	4th course for the treatment of
						Tablet in treatment group	77	16（20.8％）	19（24.7％）	20（30％）	22（28.6％）
Oral liquid treatment group	77	17（22.1％）	18（23.4％）	19（24.7％）	23（29.9％）
						Granules in Treating treatment group	76	16（21.1％）	18（23.7％）	20（26.3％）	22（28.9％）
Matched group	62	6（9.7％）	8（12.9％）	9（14.5％）	39（62.9％）

According to the clinical statistics in above table, medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, have no side effect; Treatment group is cured simultaneously, 230 examples of effective and improvement number and matched group is cured, the effective and 62 routine follow-up of patients 1 year half that takes a turn for the better, result is added up, in tablet in treatment group 77 example, healing 34 example and effective 37 examples are all without recurrence, 1 case relapsed in 6 examples of improvement, and relapse rate is 1.3%; In oral liquid treatment group 77 example, 4 examples of healing 35 example, effective 38 examples, improvement are all without recurring, and relapse rate is 0%; Cure 33 examples in Granules in Treating treatment group 76 example without recurrence, 1 case relapsed in effective 35 examples, recur 2 examples in 8 examples of improvement, relapse rate is 3.9%; Matched group is cured, effective and improvement number 62 example, recurs 6 examples, recurs 8 examples in effective 20 routine patients, recur 11 examples, relapse rate 40.3% in 27 examples of improvement in 15 routine patients of healing; Above-mentioned recurrence refers to that patient outcomes reaches healing, effective or after taking a turn for the better, and does not occur the precordialgia, uncomfortable in chest, cardiopalmus at 1 year half septum reset of following up a case by regular visits to, breathes hard.To hold concurrently disease: spontaneous perspiration, dynamic then more so, aversion to cold and cold limbs, tired, light red tongue is fat, tongue in vain, the situations such as deep-thready pulse.

Model case: Lee, male, 57 years old, the precordialgia, two months uncomfortable in chest, in addition also with cardiopalmus, breathe hard, the symptom such as spontaneous perspiration, through electrocardiogram check result be, paroxysmal supraventricular tachycardia, atrial fibrillation, slow arrhythmia electrocardiogram, cardiac blood supply deficiency electrocardiogram, tentatively be diagnosed as coronary heart disease, hope through trial inspection and the traditional Chinese medical science, hear, ask, cut and be diagnosed as qi stagnation and blood stasis type coronary heart disease further.Use the granule of the embodiment of the present invention 3, every day 3 times, every bag of 6g, one time 1 bag, medication first quarter moon is cured substantially, continues medication and cures a course for the treatment of, follow up a case by regular visits to and do not recur for 1 year half.

The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims

1. treat the medicine of qi stagnation and blood stasis type coronary heart disease for one kind, it is characterized in that, comprise following raw medicinal material: Fructus Evodiae, Fructus Aurantii, Radix Salviae Miltiorrhizae, dominoes Herba pteridii latiusculi, Flos Carthami, Delphinium brunonianum Royle, Radix Platycodonis, Radix Angelicae Pubescentis, Fructus Piperis Longi, alkali ground Chinese small iris, Lignum Aquilariae Resinatum, Radix Fissistigmatis Oldhamii, the Radix Paeoniae Alba, Herba Stephaniae Longae, Rhizoma Curcumae Longae, Radix Angelicae Sinensis, Oletum Trogopterori, Caulis et folium vitis thunbergii, Rhizoma Cyperi, Carapax Et Plastrum Testudinis, Rhizoma Sparganii, Fructus Tribuli, Herba Zanthoxyli Myriacanthi, Folium Apocyni Veneti, Poria cum Radix Pini, Rhizoma Acori Graminei, Folium Raphani, Bulbus Allii Macrostemonis, Ramulus et folium lyoniae ovalifoliae (Littlefruit Lyonia), Radix Sophorae Flavescentis, Bombyx Batryticatus, Fructus Jujubae, Herba Morinae chinensis and Radix Merremiae hungaiensis.

2. the medicine for the treatment of qi stagnation and blood stasis type coronary heart disease according to claim 1, is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Fructus Evodiae 10 ~ 25 parts, Fructus Aurantii 12 ~ 28 parts, Radix Salviae Miltiorrhizae 10 ~ 35 parts, dominoes Herba pteridii latiusculi 11 ~ 21 parts, 14 ~ 38 parts, Flos Carthami, Delphinium brunonianum Royle 13 ~ 34 parts, Radix Platycodonis 12 ~ 34 parts, Radix Angelicae Pubescentis 12 ~ 23 parts, Fructus Piperis Longi 14 ~ 25 parts, alkali ground Chinese small iris 10 ~ 20 parts, Lignum Aquilariae Resinatum 11 ~ 27 parts, Radix Fissistigmatis Oldhamii 13 ~ 36 parts, the Radix Paeoniae Alba 14 ~ 31 parts, Herba Stephaniae Longae 13 ~ 36 parts, 11 ~ 20 parts, Rhizoma Curcumae Longae, Radix Angelicae Sinensis 14 ~ 31 parts, Oletum Trogopterori 13 ~ 37 parts, Caulis et folium vitis thunbergii 11 ~ 35 parts, Rhizoma Cyperi 10 ~ 24 parts, Carapax Et Plastrum Testudinis 11 ~ 28 parts, Rhizoma Sparganii 14 ~ 36 parts, Fructus Tribuli 11 ~ 26 parts, Herba Zanthoxyli Myriacanthi 13 ~ 37 parts, Folium Apocyni Veneti 14 ~ 28 parts, Poria cum Radix Pini 12 ~ 24 parts, Rhizoma Acori Graminei 10 ~ 36 parts, Folium Raphani 10 ~ 25 parts, Bulbus Allii Macrostemonis 14 ~ 28 parts, Ramulus et folium lyoniae ovalifoliae (Littlefruit Lyonia) 12 ~ 31 parts, Radix Sophorae Flavescentis 12 ~ 26 parts, Bombyx Batryticatus 15 ~ 27 parts, 10 ~ 30 parts, Fructus Jujubae, Herba Morinae chinensis 12 ~ 22 parts and Radix Merremiae hungaiensis 14 ~ 32 parts.

3. the medicine for the treatment of qi stagnation and blood stasis type coronary heart disease according to claim 1 and 2, is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Fructus Evodiae 12 ~ 22 parts, Fructus Aurantii 14 ~ 26 parts, Radix Salviae Miltiorrhizae 11 ~ 34 parts, dominoes Herba pteridii latiusculi 13 ~ 20 parts, 15 ~ 36 parts, Flos Carthami, Delphinium brunonianum Royle 15 ~ 32 parts, Radix Platycodonis 14 ~ 33 parts, Radix Angelicae Pubescentis 12 ~ 22 parts, Fructus Piperis Longi 15 ~ 25 parts, alkali ground Chinese small iris 13 ~ 20 parts, Lignum Aquilariae Resinatum 13 ~ 26 parts, Radix Fissistigmatis Oldhamii 14 ~ 35 parts, the Radix Paeoniae Alba 15 ~ 30 parts, Herba Stephaniae Longae 15 ~ 35 parts, 12 ~ 20 parts, Rhizoma Curcumae Longae, Radix Angelicae Sinensis 15 ~ 30 parts, Oletum Trogopterori 14 ~ 36 parts, Caulis et folium vitis thunbergii 12 ~ 34 parts, Rhizoma Cyperi 11 ~ 23 parts, Carapax Et Plastrum Testudinis 12 ~ 26 parts, Rhizoma Sparganii 15 ~ 35 parts, Fructus Tribuli 13 ~ 24 parts, Herba Zanthoxyli Myriacanthi 14 ~ 36 parts, Folium Apocyni Veneti 15 ~ 26 parts, Poria cum Radix Pini 14 ~ 22 parts, Rhizoma Acori Graminei 12 ~ 34 parts, Folium Raphani 11 ~ 23 parts, Bulbus Allii Macrostemonis 15 ~ 25 parts, Ramulus et folium lyoniae ovalifoliae (Littlefruit Lyonia) 15 ~ 30 parts, Radix Sophorae Flavescentis 14 ~ 24 parts, Bombyx Batryticatus 15 ~ 25 parts, 12 ~ 30 parts, Fructus Jujubae, Herba Morinae chinensis 14 ~ 20 parts and Radix Merremiae hungaiensis 15 ~ 30 parts.

4. the medicine of the treatment qi stagnation and blood stasis type coronary heart disease according to any one of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Fructus Evodiae 15 parts, Fructus Aurantii 20 parts, Radix Salviae Miltiorrhizae 32 parts, dominoes Herba pteridii latiusculi 18 parts, 35 parts, Flos Carthami, Delphinium brunonianum Royle 30 parts, Radix Platycodonis 22 parts, Radix Angelicae Pubescentis 20 parts, Fructus Piperis Longi 20 parts, alkali ground Chinese small iris 15 parts, Lignum Aquilariae Resinatum 25 parts, Radix Fissistigmatis Oldhamii 32 parts, the Radix Paeoniae Alba 30 parts, Herba Stephaniae Longae 34 parts, 16 parts, Rhizoma Curcumae Longae, Radix Angelicae Sinensis 28 parts, Oletum Trogopterori 35 parts, Caulis et folium vitis thunbergii 33 parts, Rhizoma Cyperi 22 parts, Carapax Et Plastrum Testudinis 24 parts, Rhizoma Sparganii 32 parts, Fructus Tribuli 20 parts, Herba Zanthoxyli Myriacanthi 35 parts, Folium Apocyni Veneti 24 parts, Poria cum Radix Pini 20 parts, Rhizoma Acori Graminei 34 parts, Folium Raphani 15 parts, Bulbus Allii Macrostemonis 22 parts, Ramulus et folium lyoniae ovalifoliae (Littlefruit Lyonia) 30 parts, Radix Sophorae Flavescentis 20 parts, Bombyx Batryticatus 25 parts, 30 parts, Fructus Jujubae, Herba Morinae chinensis 16 parts and Radix Merremiae hungaiensis 25 parts.

5. the medicine of the treatment qi stagnation and blood stasis type coronary heart disease according to any one of claim 1-4, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Fructus Evodiae 22 parts, Fructus Aurantii 25 parts, Radix Salviae Miltiorrhizae 34 parts, dominoes Herba pteridii latiusculi 20 parts, 35 parts, Flos Carthami, Delphinium brunonianum Royle 30 parts, Radix Platycodonis 31 parts, Radix Angelicae Pubescentis 14 parts, Fructus Piperis Longi 23 parts, alkali ground Chinese small iris 20 parts, Lignum Aquilariae Resinatum 15 parts, Radix Fissistigmatis Oldhamii 35 parts, the Radix Paeoniae Alba 24 parts, Herba Stephaniae Longae 33 parts, 16 parts, Rhizoma Curcumae Longae, Radix Angelicae Sinensis 30 parts, Oletum Trogopterori 34 parts, Caulis et folium vitis thunbergii 32 parts, Rhizoma Cyperi 22 parts, Carapax Et Plastrum Testudinis 24 parts, Rhizoma Sparganii 35 parts, Fructus Tribuli 20 parts, Herba Zanthoxyli Myriacanthi 33 parts, Folium Apocyni Veneti 25 parts, Poria cum Radix Pini 20 parts, Rhizoma Acori Graminei 34 parts, Folium Raphani 22 parts, Bulbus Allii Macrostemonis 25 parts, Ramulus et folium lyoniae ovalifoliae (Littlefruit Lyonia) 30 parts, Radix Sophorae Flavescentis 21 parts, Bombyx Batryticatus 22 parts, 30 parts, Fructus Jujubae, Herba Morinae chinensis 15 parts and Radix Merremiae hungaiensis 26 parts.

6. the medicine of the treatment qi stagnation and blood stasis type coronary heart disease according to any one of claim 1-5, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Fructus Evodiae 12 parts, Fructus Aurantii 24 parts, Radix Salviae Miltiorrhizae 33 parts, dominoes Herba pteridii latiusculi 20 parts, 35 parts, Flos Carthami, Delphinium brunonianum Royle 32 parts, Radix Platycodonis 23 parts, Radix Angelicae Pubescentis 20 parts, Fructus Piperis Longi 24 parts, alkali ground Chinese small iris 20 parts, Lignum Aquilariae Resinatum 25 parts, Radix Fissistigmatis Oldhamii 33 parts, the Radix Paeoniae Alba 26 parts, Herba Stephaniae Longae 34 parts, 18 parts, Rhizoma Curcumae Longae, Radix Angelicae Sinensis 28 parts, Oletum Trogopterori 35 parts, Caulis et folium vitis thunbergii 32 parts, Rhizoma Cyperi 20 parts, Carapax Et Plastrum Testudinis 23 parts, Rhizoma Sparganii 34 parts, Fructus Tribuli 21 parts, Herba Zanthoxyli Myriacanthi 35 parts, Folium Apocyni Veneti 25 parts, Poria cum Radix Pini 20 parts, Rhizoma Acori Graminei 33 parts, Folium Raphani 20 parts, Bulbus Allii Macrostemonis 18 parts, Ramulus et folium lyoniae ovalifoliae (Littlefruit Lyonia) 24 parts, Radix Sophorae Flavescentis 16 parts, Bombyx Batryticatus 22 parts, 28 parts, Fructus Jujubae, Herba Morinae chinensis 20 parts and Radix Merremiae hungaiensis 30 parts.

7. the preparation method of the medicine of the treatment qi stagnation and blood stasis type coronary heart disease according to any one of claim 1-6, is characterized in that, when the dosage form of described medicine is tablet, its preparation method comprises the following steps:

8. the preparation method of the medicine of the treatment qi stagnation and blood stasis type coronary heart disease according to any one of claim 1-6, is characterized in that, when the dosage form of described medicine is oral liquid, its preparation method comprises the following steps:

9. the preparation method of the medicine of the treatment qi stagnation and blood stasis type coronary heart disease according to any one of claim 1-6, is characterized in that, when the dosage form of described medicine is granule, its preparation method comprises the following steps: