CN103989969A

CN103989969A - Traditional Chinese medicament for treating wind-cold obstruction type cervical spondylotic radiculopathy and preparation method thereof

Info

Publication number: CN103989969A
Application number: CN201410265247.6A
Authority: CN
Inventors: 刘海春; 李逸
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-06-16
Filing date: 2014-06-16
Publication date: 2014-08-20

Abstract

The invention discloses a traditional Chinese medicament for treating wind-cold obstruction type cervical spondylotic radiculopathy and a preparation method thereof. The traditional Chinese medicinal composition is prepared from externally-applied medicinal materials and oral medicinal materials, wherein the oral medicinal materials comprise Chinese angelica, herba aristolochiae, ligusticum wallichii, tinospora sinensis, corydalis tuber, resina liquidamberis, safflower, loofah sponge, peltateleaf raspberry fruit, salviae miltiorrhizae, Chinese trumpet creeper, narcissus, gastrodia elata, cortex periplocae, yam rhizome, earthworm, bombyx batryticatus, pimpinelathelungiana wolf, odobenus rosmarus, leycesteria formosa, praw shell, sea-buckthorn, rhodiola rosea and longan pulp; the externally-applied medicinal materials comprise salviae miltiorrhizae, tinospora sinensis, motherwort, elderberry, peltateleaf raspberry fruit and gastrodia elata. The traditional Chinese medicament is used for treating wind-cold obstruction type cervical spondylotic radiculopathy by utilizing traditional Chinese medical theory and taking tendon-relaxing and collateral-activating, wind-expelling and pain-relieving as main treatment principle, can be used for dredging channels, relieving pain, preventing myophagism and restoring normal movement functions of muscle and joints, and has the advantages of quick response, exact curative effect, high safety, no toxic or side effects and relapse prevention.

Description

Be used for the treatment of Chinese medicine of wind chill blockage type cervical spondylotic radiculopathy and preparation method thereof

Technical field

The present invention relates to pharmaceutical technology, relate in particular to a kind of Chinese medicine that is used for the treatment of wind chill blockage type cervical spondylotic radiculopathy and preparation method thereof.

Background technology

Cervical spondylosis claims again cervical spine syndrome, is the general name of osteoarthritis of cervical spine, proliferative cervical spondylosis, cervical syndrome, Cervical disc extrusion, is a kind ofly with degeneration pathology, to change into basic illness.Mainly due to cervical vertebra strain for a long time, hyperosteogeny, or prolapse of intervertebral disc, ligament thicken, and causes cervical vertebra spinal cord, nerve root or vertebral artery pressurized, occurs a series of handicapped clinical syndromes.Show as intervertebral disc degradation itself and insecondary a series of pathological change thereof, as vertebra joint unstability, loosening; Vertebral pulp is given prominence to or is deviate from; Bony spur forms; The spinal canal stenosis of ligament plumpness and secondary etc., stimulate or have oppressed the contiguous tissues such as nerve root, spinal cord, vertebral artery and cervical region sympathetic nerve, cause series of symptoms and sign.Cervical spondylosis can be divided into: cervical spondylopathy, cervical spondylotic radiculopathy, cervical spondylotic myelopathy, vertebral artery type of cervical spondylosis, sympathetic type of cervical spondylosis, esophagus compressive cervical spondylosis.

The cause of disease of cervical spondylotic radiculopathy: vertebral pulp outstanding or deviate from, the hyperosteogeny in little joint, rear or traumatic arthritis, the bony spur of uncovertebral joint forms, and the loosening and displacement in three adjacent joints (the little joint in articulatio intercentralis, uncovertebral joint and rear) etc. all can cause and stimulate and compressing spinal nerve root.In addition the adhesive arachnoiditis at narrow, the root sleeve place of root pipe the and around inflammation at position and tumor etc. also can cause the symptom similar with primary disease.

The clinical manifestation of cervical spondylotic radiculopathy has the following aspects: 1. neck symptom, depending on causing the reason difference of root pressurized, weight differs.Mainly because of vertebral pulp outstanding due to person, because local hole nervi vertebralis is directly stimulated how with significantly cervical region pain, paravertebral muscles tenderness and the cervical region formula position of attentioning, cervical spine or interspinal direct tenderness or kowtow pain and mostly be positive, and these performances be take acute stage especially for obvious.As be the regression of pure uncovertebral joint and caused by hyperosteogeny person, neck symptom is slighter, even can be without special discovery.2. a property pain, the most common, and its scope is consistent with the spinal nerve root distributed areas of the vertebra joint of getting involved.What bitterly accompany with root is other sensory disturbances of this nerve root areal area, wherein take numbness of the fingers, finger tip hyperesthesia and dermal sensation to go down etc. as common.3. a property muscular strength obstacle, the first pressurized person of former root be obviously, muscular hypertonia in early days, but weaken very soon and occur amyotrophy.Its scope of getting involved is also only confined to the flesh group that this spinal nerve root is arranged.At hand, take large and small thenar and interosseus as obviously.4. tendon reflex changes, and the reflex arc that the spinal nerve root of getting involved participates in occurs abnormal.Early stage active, the intermediary and later stages go down or disappear, and during inspection, should compare with offside.The pathologic reflex that do not have of getting involved of simple root, as with pathologic reflex, represents that spinal cord gets involved simultaneously.5. sign, the tractive test of all increase spinal nerve root tension force is mostly positive, especially acute stage and later root pressurized be main person.Cervical vertebra squeeze test positive be more common in take that vertebral pulp is outstanding, vertebral pulp is deviate from and vertebra joint unstable be main case, and because person due to hook vertebra hypertrophy is mostly the weak positive, because of Intraspinal Occupying Lesion institute causer, be mostly negative.

Chinese medicine thinks, the formation of cervical spondylosis is due to caused by liver and kidney deficiency, and muscles and bones decline is chronic accumulation strain in addition, so that space between skin and muscles is empty, QI and blood declines less, muscles and bones is lost in moistening fosterly, and wind-cold damp pathogen is invaded, numbness resistance meridians, caused by energy stagnation and blood stasis.Primary disease can be divided into neck type, arthralgia pain type, paralytic, vertiginous type, common with neck type and arthralgia pain type.Cervical spondylotic radiculopathy belongs to the category of motherland's medical science " numbness ".Analyze the cause of disease of primary disease, main and weakened body resistance strain, being invaded by exogenous pathogen is relevant, deficiency of vital QI, insufficiency of vital energy and blood, muscle arteries and veins loses supports, therefore Rong Ze pain not; Bend over the desk for a long time, strain excessively, injures muscle arteries and veins, napex stagnation of QI-blood, or the exopathogen such as wet that is affected by the cold, and obstruction of meridians and collaterals, QI and blood is obstructed, therefore stagnation of QI and blood may bring about pain.Therefore distinguish that its clinical disease is divided into: types such as wind chill blockage, qi depression to blood stasis, phlegm-damp resistance network, deficiency of the liver and kindey, deficiency of qi and blood.Wind chill blockage type wherein: patient's neck, shoulder, upper limb string pain numbness, take pain as main, head has sense of heaviness, and Wry Neck is movable unfavorable, aversion to cold anemophobia, light red tongue, white and thin fur, stringy and tense pulse.

The method for the treatment of cervical spondylotic radiculopathy mainly contains non-operative treatment treatment and operative treatment at present, the method that non-operative treatment is conventional has: naturopathy, traction therapeutic, various Chinese patent medicine, Western medicine etc., although can be good at alleviating pain, but effect is still undesirable, exist treatment time long, weak curative effect and have the defects such as side effect.

Summary of the invention

Technical problem to be solved by this invention is, a kind of Chinese medicine that is used for the treatment of wind chill blockage type cervical spondylotic radiculopathy and preparation method thereof is provided, this Chinese medicine composition utilizes Traditional Chinese medical theory, take Overall View as basis, with dialectical opinion, control as instructing, with relaxing muscles and tendons and activating QI and blood in the collateral, wind-expelling pain-stopping is primary treatment principle, treatment cervical spondylotic radiculopathy can dredging the meridian, alleviating pain, prevent amyotrophy, recover the proper motion function in muscle joint, can also improve patient's overall immunity, improve the ability that body is resisted pathogenic factor, selected natural Chinese medicines material, low price, have rapid-action, determined curative effect, safe, the advantage that has no side effect and be difficult for recurring.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine that is used for the treatment of wind chill blockage type cervical spondylotic radiculopathy, wherein, comprise external used medicine and endo-medicine, described endo-medicine comprises: Radix Angelicae Sinensis, Herba Aristolochiae, Rhizoma Chuanxiong, Caulis Tinosporae, Rhizoma Corydalis, Resina Liquidambaris, Flos Carthami, Retinervus Luffae Fructus, Fructus Rubi Peltati, Radix Salviae Miltiorrhizae, Flos Campsis, Flos Narcissi chinensis, Rhizoma Gastrodiae, Cortex Periplocae, Rhizoma Dioscoreae Septemlobae, Pheretima, Bombyx Batryticatus, Herba Pimpinellae thellungianae, Hippocampus, hollow wood, prawn shell, Fructus Hippophae, Radix Rhodiolae and Arillus Longan; Described external used medicine comprises: Radix Salviae Miltiorrhizae, Caulis Tinosporae, Herba Leonuri, Ramulus Sambuci Williamsii, Fructus Rubi Peltati and Rhizoma Gastrodiae.

In described endo-medicine, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 20-30 weight portion, Herba Aristolochiae 10-15 weight portion, Rhizoma Chuanxiong 10-20 weight portion, Caulis Tinosporae 15-30 weight portion, Rhizoma Corydalis 10-20 weight portion, Resina Liquidambaris 10-15 weight portion, Flos Carthami 20-30 weight portion, Retinervus Luffae Fructus 20-25 weight portion, Fructus Rubi Peltati 20-30 weight portion, Radix Salviae Miltiorrhizae 20-30 weight portion, Flos Campsis 10-20 weight portion, Flos Narcissi chinensis 10-20 weight portion, Rhizoma Gastrodiae 20-30 weight portion, Cortex Periplocae 20-25 weight portion, Rhizoma Dioscoreae Septemlobae 10-15 weight portion, Pheretima 5-15 weight portion, Bombyx Batryticatus 20-30 weight portion, Herba Pimpinellae thellungianae 10-15 weight portion, Hippocampus 10-15 weight portion, hollow wooden 10-20 weight portion, prawn shell 10-25 weight portion, Fructus Hippophae 10-20 weight portion, Radix Rhodiolae 10-20 weight portion and Arillus Longan 10-20 weight portion,

In described external used medicine, the parts by weight of each raw medicinal material are: Radix Salviae Miltiorrhizae 20-30 weight portion, Caulis Tinosporae 15-25 weight portion, Herba Leonuri 10-20 weight portion, Ramulus Sambuci Williamsii 10-15 weight portion, Fructus Rubi Peltati 10-15 weight portion and Rhizoma Gastrodiae 10-20 weight portion.

In described endo-medicine, the parts by weight of each raw medicinal material are preferably: Radix Angelicae Sinensis 25 weight portions, Herba Aristolochiae 12 weight portions, Rhizoma Chuanxiong 15 weight portions, Caulis Tinosporae 22 weight portions, Rhizoma Corydalis 15 weight portions, Resina Liquidambaris 12 weight portions, Flos Carthami 25 weight portions, Retinervus Luffae Fructus 22 weight portions, Fructus Rubi Peltati 25 weight portions, Radix Salviae Miltiorrhizae 25 weight portions, Flos Campsis 15 weight portions, Flos Narcissi chinensis 15 weight portions, Rhizoma Gastrodiae 25 weight portions, Cortex Periplocae 23 weight portions, Rhizoma Dioscoreae Septemlobae 13 weight portions, Pheretima 8 weight portions, Bombyx Batryticatus 25 weight portions, Herba Pimpinellae thellungianae 12 weight portions, Hippocampus 12 weight portions, hollow wooden 15 weight portions, prawn shell 17 weight portions, Fructus Hippophae 15 weight portions, Radix Rhodiolae 15 weight portions and Arillus Longan 15 weight portions,

In described external used medicine, the parts by weight of each raw medicinal material are preferably: Radix Salviae Miltiorrhizae 25 weight portions, Caulis Tinosporae 21 weight portions, Herba Leonuri 15 weight portions, Ramulus Sambuci Williamsii 12 weight portions, Fructus Rubi Peltati 12 weight portions and Rhizoma Gastrodiae 15 weight portions.

In described endo-medicine, the parts by weight of each raw medicinal material can also be preferably: Radix Angelicae Sinensis 30 weight portions, Herba Aristolochiae 15 weight portions, Rhizoma Chuanxiong 10 weight portions, Caulis Tinosporae 15 weight portions, Rhizoma Corydalis 10 weight portions, Resina Liquidambaris 15 weight portions, Flos Carthami 30 weight portions, Retinervus Luffae Fructus 25 weight portions, Fructus Rubi Peltati 20 weight portions, Radix Salviae Miltiorrhizae 20 weight portions, Flos Campsis 10 weight portions, Flos Narcissi chinensis 20 weight portions, Rhizoma Gastrodiae 20 weight portions, Cortex Periplocae 25 weight portions, Rhizoma Dioscoreae Septemlobae 15 weight portions, Pheretima 5 weight portions, Bombyx Batryticatus 30 weight portions, Herba Pimpinellae thellungianae 10 weight portions, Hippocampus 10 weight portions, hollow wooden 10 weight portions, prawn shell 25 weight portions, Fructus Hippophae 20 weight portions, Radix Rhodiolae 10 weight portions and Arillus Longan 10 weight portions,

In described external used medicine, the parts by weight of each raw medicinal material can also be preferably: Radix Salviae Miltiorrhizae 20 weight portions, Caulis Tinosporae 25 weight portions, Herba Leonuri 20 weight portions, Ramulus Sambuci Williamsii 10 weight portions, Fructus Rubi Peltati 15 weight portions and Rhizoma Gastrodiae 10 weight portions.

In order better to realize foregoing invention object, the present invention also provides a kind of preparation method that is used for the treatment of the Chinese medicine of wind chill blockage type cervical spondylotic radiculopathy, and when the dosage form of endo-medicine is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion described each raw medicinal material, adds the ethanol that the determining alcohol with respect to 2～4 times of mixture qualities is 85～95%, and reflux 1～3 hour is extracted, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 1～2 times of described medicinal residues quality is 85～95% again, and reflux 1～3 hour, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes, and sieves, and obtains 300 order～400 object micropowders;

The 3rd step, the micropowders that second step is obtained, add microcrystalline Cellulose with respect to 0.1～0.3 times of its quality, 0.05～0.15 times of lactose, the starch of 0.1～0.3 times, sieve, mix homogeneously, granulate, dry, add with respect to 0.005～0.05 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.

When the dosage form of endo-medicine is syrup, its preparation method comprises the following steps:

The first step, mixes Radix Angelicae Sinensis, Herba Aristolochiae, Rhizoma Chuanxiong, Caulis Tinosporae and Rhizoma Corydalis in described ratio, use the dissolve with ethanol with respect to the determining alcohol 85%～95% of 3～5 times of the mixture quality obtaining, and reflux was extracted after 2～4 hours, filters, and obtains the first filtrate; Filtering residue is used to the dissolve with ethanol with respect to the determining alcohol 85%～95% of 1～2 times of the mixture quality obtaining again, and reflux was extracted after 1～2 hour, filtered, and obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, utilize the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, with the determining alcohol of 3 times of resin column volumes, be 90%～95% ethanol elution again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;

Second step, Retinervus Luffae Fructus, Fructus Rubi Peltati, Radix Salviae Miltiorrhizae and Cortex Periplocae are mixed in described ratio, the alcohol heating reflux adding with respect to the determining alcohol 85%～95% of 2～4 times of the mixture quality obtaining extracts 2～3 times, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 ℃ under the condition of 60 ℃～70 ℃, relative density is 1.20～1.23, is dried to powder by the mastic after concentrated with spray dryer;

The 3rd step, mixes surplus stock medical material in described ratio, add the water dissolution of 2～4 times with respect to the mixture quality obtaining, and heating decocts 2～4 hours, filters; Filtering residue is used to the water dissolution of 1～2 times with respect to the mixture quality obtaining again, and heating decocts 1～2 hour, filters; Merge the filtrate of twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;

The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, and adds the water dissolution with respect to 1.5～2 times of mixture qualities, with 40% sodium hydroxide solution, regulate pH value to 7.0, stir evenly, under 4 ℃～8 ℃ conditions, cold preservation is 48 hours～72 hours, filter, filtrate adds the sucrose with respect to 0.2～0.4 times of the mixture quality obtaining, and stirs and dissolves, regulate pH value to 7.0, add water appropriate, stir, static 12～18 hours, filter fill, sterilizing, obtains syrup.

When the dosage form of external used medicine is paster agent, its preparation method comprises the following steps:

The first step, mixes Radix Angelicae Sinensis, Herba Aristolochiae, Rhizoma Chuanxiong, Caulis Tinosporae and Rhizoma Corydalis in described ratio, use the dissolve with ethanol with respect to the determining alcohol 85%～95% of 3～5 times of the mixture quality obtaining, and reflux was extracted after 2～4 hours, filters, and obtains the first filtrate; Filtering residue is used to the dissolve with ethanol with respect to the determining alcohol 85%～95% of 1～2 times of the mixture quality obtaining again, and reflux was extracted after 1～2 hour, filtered, and obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, the macroporous adsorptive resins eluting that is 5L through volume, first use deionized water or the distilled water eluting of 5 times of resin column volumes, with the determining alcohol of 3 times of resin column volumes, be 90%～95% ethanol elution again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;

The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, and adds with respect to the rubber of 1～2 times of each raw medicinal material quality sum of described Chinese medicine, the Colophonium of 1～2 times, mixes, make coating, be coated with cream, cut off, lid lining, section, obtains described paster agent.

Beneficial effect of the present invention is: the present invention utilizes Traditional Chinese medical theory, take Overall View as basis, with dialectical opinion, control as instructing, take relaxing muscles and tendons and activating QI and blood in the collateral, wind-expelling pain-stopping is primary treatment principle treatment wind chill blockage type cervical spondylotic radiculopathy, oral administration and externally combines, can dredging the meridian, alleviating pain, prevent amyotrophy, recover the proper motion function in muscle joint, can also improve patient's overall immunity, improve body and resist the ability of pathogenic factor, and there is rapid-action, determined curative effect, safe, the advantage that has no side effect and be difficult for recurring.

The specific embodiment

Chinese medicine thinks, primary disease is pathogen numbness resistance meridians, due to QI-blood circulation is smooth.Therefore, the present invention treats cervical spondylotic radiculopathy with relaxing muscles and tendons and activating QI and blood in the collateral, wind-expelling pain-stopping is primary treatment principle, selects endo-medicine prescription to be: Radix Angelicae Sinensis, Herba Aristolochiae, Rhizoma Chuanxiong, Caulis Tinosporae, Rhizoma Corydalis, Resina Liquidambaris, Flos Carthami, Retinervus Luffae Fructus, Fructus Rubi Peltati, Radix Salviae Miltiorrhizae, Flos Campsis, Flos Narcissi chinensis, Rhizoma Gastrodiae, Cortex Periplocae, Rhizoma Dioscoreae Septemlobae, Pheretima, Bombyx Batryticatus, Herba Pimpinellae thellungianae, Hippocampus, hollow wood, prawn shell, Fructus Hippophae, Radix Rhodiolae and Arillus Longan; Select external used medicine to be: Radix Salviae Miltiorrhizae, Caulis Tinosporae, Herba Leonuri, Ramulus Sambuci Williamsii, Fructus Rubi Peltati and Rhizoma Gastrodiae.

Wherein, Radix Angelicae Sinensis, Herba Aristolochiae regulating QI to relieve pain; Rhizoma Chuanxiong, Caulis Tinosporae, Rhizoma Corydalis, Resina Liquidambaris, Flos Carthami, Retinervus Luffae Fructus, Radix Salviae Miltiorrhizae, Flos Campsis, Flos Narcissi chinensis, hollow wood, Herba Leonuri, Ramulus Sambuci Williamsii promoting blood circulation to restore menstrual flow, removing obstruction in the collateral to relieve pain; Prawn shell ataralgesia; Rhizoma Gastrodiae, Fructus Rubi Peltati, Cortex Periplocae, Rhizoma Dioscoreae Septemlobae, Pheretima, Bombyx Batryticatus dispelling wind and removing obstruction in the collateral; Herba Pimpinellae thellungianae, Hippocampus, Fructus Hippophae, Radix Rhodiolae, Arillus Longan benefiting QI for activating blood circulation.

Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:

Radix Angelicae Sinensis: sweet, acrid, warm.Return liver, the heart, spleen channel.Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.

Herba Aristolochiae: hardship, temperature; Enter liver,spleen,kidney warp.< < Bencao Tujing > >: " Xie Fenglao.The Herba Ephedrae cold diaphoresis that cures the wound, with Radix Et Rhizoma Rhei with clothes induced abortion gas." < < book on Chinese herbal medicine is new > > again: " removing heat from blood and promoting blood circulation, removes wind dampness removing, walks meridians, the double swollen pain of waist lower limb of controlling." circulation of qi promoting removing dampness, promoting blood circulation and stopping pain.Treat for stomachache, colicky, edema during pregnancy, puerperal, vim and vigour were suffered from abdominal pain, rheumatalgia.Promoting flow of QI and blood, pain relieving, diuresis.Edema during pregnancy, breast stomachache, colic, rheumatalgia.Herba Aristolochiae, gas is invigorated blood circulation, and controls the medicine of all pains also.The gas of the person, suitable peaceful, contrary pain vexed work.As > > Herba Aristolochiae in the Young < < side of directing at is controlled the brachialgia of expectorant note, gas stays colic, abdominal mass is poly-, renal mass stomachache, and puerperal, vim and vigour were suffered from abdominal pain, he is as edema during pregnancy, edema over the face tachypnea, man's wind labor, chronic cough is not healed, know with this medicine and control it, the peace of invariably getting into bed.Therefore Gai Weiqi is good at popular vim and vigour also.See book and discuss and cure mainly, only belong to the diseases such as pregnant edema during pregnancy, stomachache, wind consumptive disease, in his disease not and here.Be its reason of controlling, also only because bitter in the mouth master is in catharsis, warm in nature being led to lives, thus the passage of invigorating blood circulation, and make water without unfavorable, and wind removes invariably, and blood is lived invariably, therefore pain is all controlled also invariably with swollen.

Rhizoma Chuanxiong: acrid in the mouth, warm in nature; Return liver, gallbladder, heart channel.< < Sheng Nong's herbal classic > >: " main apoplexy enters brain headache, arthralgia due to cold, and muscle moderate pulse is anxious, incised wound, and married woman's blood closes loss of fecundity." < < Japan hanako materia medica > >: " control a wind cutting, all gas, all strains, all blood, mend five kinds of over strain, strengthening bone and muscle, adjust many arteries and veins, broken crux stagnated blood, supports fresh blood, put on flesh, serious epistaxis, spits blood and hematuria, hemorrhoid complicated by anal fistula, brain carbuncle carbuncle on the back, scrofula wart is superfluous, skin ulcer scabies, and evacuation of pus repercussive blood." gas fragrant rise loose.There is blood-activating and qi-promoting, the effect of wind-expelling pain-stopping.Cure mainly menoxenia, dysmenorrhea, amenorrhea, difficult labour, retention of placenta, lochia stomachache, lump, heart pain in chest and hypochondrium, traumatic injury swells and ache, headache vertigo and head dark, anemofrigid-damp arthralgia, numb limbs and tense tendons, ulcer sores.For headache due to common cold, the diseases such as migraine and general headache.The pungent perfume (or spice) of Rhizoma Chuanxiong is kind to be risen, and can push up on up head mountain peak, has wind-expelling pain-stopping effect, for controlling wind syndrome of head headache key medicine.In addition clinical conventional this product treatment angina pectoris.The pungent temperature of Rhizoma Chuanxiong is fragrant dry, walks and does not keep, can go loose, the up top, mountain peak that reaches; Enter again blood system, the descending sea of blood that reaches.Ligustrazine energy coronary artery dilator, increases coronary artery blood flow, improves myocardium blood oxygen supply, and reduces myocardium oxygen consumption; The expansible cerebrovascular of ligustrazine, reduces vascular resistance, significantly increases brain and LBF amount, improves microcirculation; Can reduce surface activity of blood platelet, suppress platelet aggregation, the formation of pre-preventing thrombosis.

Caulis Tinosporae: hardship, cold.Function cures mainly: 1. < < Nanning City medicine will > >: " relaxing muscles and tendons and activating QI and blood in the collateral, parasite killing.External application traumatic injury tendon breaking, rheumatic ostalgia; Relaxing muscles and tendons and activating QI and blood in the collateral for oral administration." 2. the < < of Guangzhou army commonly uses Chinese herbal medicine handbook > >: " relaxing muscles and tendons and activating QI and blood in the collateral, clearing away heat-damp and promoting diuresis.Dispelling the wind and dampness pathogens bones and muscles pain, lumbar muscle strain, traumatic injury."

Rhizoma Corydalis: invigorate blood circulation, dissipating blood stasis, regulates the flow of vital energy, pain relieving.The all pains of main trusted subordinate's waist knee joint, menoxenia, lump in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.1, analgesic activity: Rhizoma Corydalis powder has analgesic activity, its pain relieving is tired and is about 1/100 of opium; Rhizoma Corydalis total alkaloids, Corydaline, second element, ugly element, the last of the ten Heavenly stems, element all had analgesic activity, stronger with second element. and various dosage forms are strong with alcohol extractum processed and powder effect.2, calm, stable, syngignoscism: tetrahydropalmatine has certain calmness, stable effect, and its levo form is novel central inhibitor, during larger dose, rabbit, Canis familiaris L., monkey is had to obvious syngignoscism.3, the impact on digestive system: dehydrogenation Corydaline has significant anti-Experimental Gastric Ulcer in Rats effect.4, to cardiovascular effect: tetrahydropalmatine, uglyly have slight blood pressure lowering, a decreased heart rate effect; Dehydrocory daline has blood pressure lowering, increases CBSF effect. the downright bad effect of rat heart muscle that ethanol extract also has coronary artery dilating, antagonism isoproterenol to cause.

Resina Liquidambaris: pungent, hardship, flat; Return spleen, lung, Liver Channel.Function expelling wind and activating blood circulation, removing toxic substances pain relieving, hemostasia and promoting granulation.For carbuncle, skin ulcer rash, scrofula, toothache, arthralgia pain, paralysis, spits blood, epistaxis, spitting of blood, traumatic hemorrhage, chapped skin.Resina Liquidambaris and volatile oil experiment in vitro thereof can make Sanguis Leporis seu oryctolagi bolt contraction in length and weight (weight in wet base and dry weight) alleviate, and in body experiment, show that can obviously suppress rat suppository forms; Test tube method experiment shows obviously to improve plasmin activity, significantly improves cAMP content in platelet.Show Resina Liquidambaris and volatile oil anti thrombotic action thereof and and promote fibrinolytic and improve platelet cAMP relevant, and to point out volatile oil may be the main hemostatic compositions of Resina Liquidambaris.

Flos Carthami: warm in nature, acrid in the mouth, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury.When ancients often have what blood in vivo, often add Flos Carthami tate.Bundle is boiled available one day twice foot bath, applicable various varicosis, and peripheral neuritis, blood circulation is bad, lower limb numbness or the congestion such as livid purple.Flos Carthami decoct low dose can make Bufo siccus isolated heart and rabbit in slightly excitement of systemic heart, makes heart beating strong, and amplitude strengthens; Heavy dose has inhibitory action to heart, makes decreased heart rate, and myocardial contraction weakens, and cardiac output reduces.Rabbit, rat, dog etc., cause on the animal model of expeirmental myocardial ischemia or myocardial infarction, Flos Carthami and preparation thereof all have antagonism in various degree.As first, with the Rockwell liquid perfusion blood vessel containing micro-epinephrine or norepinephrine, make animal myocardium vessel smooth muscle contraction keep certain vascular tone, cause may similar people obstructed, the state of blood stasis of blood vessels.Flos Carthami decoct, Carthamus yellow and other preparations all have rapid depressurization effect in various degree to anesthetized cat or dog, and mean blood pressure declines about 20 mm Hg, continue to recover after approximately 30 minutes.

Retinervus Luffae Fructus: sweet, flat.Return lung, stomach, Liver Channel.Function cures mainly: dredging collateral, invigorate blood circulation, and dispel the wind.For arthralgia pain contracture, distending pain in the chest and hypochondrium, galactostasis.

Fructus Rubi Peltati: salty, sour; Temperature.Return kidney channel.Function cures mainly: strengthening waist and kidney, wind-expelling pain-stopping.Main extremities joint pain, ache of the spinal column.

Radix Salviae Miltiorrhizae: bitter in the mouth, cold in nature, enter the heart, Liver Channel, there is the effect of blood circulation promoting and blood stasis dispelling, promoting tissue regeneration by removing blood stasis, removing heat from blood mind calming, be mainly used in the ambition of stagnation of QI and blood, the twinge of the breast side of body, sensation of oppression over the chest with shortness of breath, abdominal distention; The menoxenia of women's disharmony between QI and blood, dysmenorrhoea amenorrhea; Stagnation of QI-blood, the symptoms such as trusted subordinate's pain, Radix Salviae Miltiorrhizae can reduce as interior fat and testis fatty around, alleviates insulin secretion and glycometabolic early stage infringement.Strengthen myocardial contraction, improve cardiac function, do not increase myocardial oxygen consumption.Coronary artery dilating, increases myocardial flow; Expansion peripheral blood vessel, blood flow increases; Cerebral blood flow declines, and improves plasmin activity; Extend, clotting time; Anticoagulant (improving cAMP level inhibition TXA2 in platelet synthesizes); Improve hemorheological properties (blood viscosity reduction, erythrocyte electrophoretic time shorten).Radix Salviae Miltiorrhizae Tabellae is the Chinese patent medicine of blood circulation promoting and blood stasis dispelling, regulating QI to relieve pain.The disease such as be mainly used in angina pectoris, hypertension, cervical spondylosis and feel oppressed in the heart.And the side effect reliable, Radix Salviae Miltiorrhizae Tabellae of its drug effect is little.But that can not eat is too frequent.Because long-term taking FUFANG DANSHEN PIAN may cause blood potassium content and reduce, produce hypokalemia.

Flos Campsis: sweet, sour, cold; Return liver, pericardium channel.< < Compendium of Materia Medica > >: " stem and leaf band is bitter for Ling Leihua and root, sweet acid and trembling with fear, and promoting the circulation of blood divides, and the fire second of the three ten-day periods of the hot season of dehematizing, therefore the card of the main product breast all diseases of metrorrhagia and blood hot air wind producing also." < < herbal classic meets former > >: " and Ling Xuehua, metopodynia blood closes, pricking caused by the stagnation of QI and blood, strict wind malignant boil multiplex it, all get the merit of its dispelling malignant blood also." < < Sheng Nong's herbal classic > >: " and the remaining disease of housewife people's galactopoiesis, metrorrhagia, lump in the abdomen, blood closes, cold and heat weakness and emaciation." promoting the circulation of blood blood stasis removing, cooling blood, expelling wind.For Jing Bi WEIJIA, puerperal swelling of the breast, rubella is rubescent, skin pruritus, acne.

Flos Narcissi chinensis: pungent; Cool.Return liver; Lung meridian.Function cures mainly: happy god clears away heart-fire; Regulating QI to promote menstruation; Removing toxic substances is warded off dirty.Main Mental fatigue is dizzy; Menoxenia; Dysentery; Skin ulcer is swollen.

Rhizoma Gastrodiae: sweet flat, return Liver Channel.< < herbal classic is met former > >: " though Rhizoma Gastrodiae is not dry, wind agent after all, if blood deficiency is calm, the scorching headache of fire, xerostomia are not just closed person, can not abuse." embellish but not dry, master enters Liver Channel, is longer than suppressing the hyperactive liver to relieve the wind syndrome, and the disease of all liver-wind stirring up internallys, the vertigo, no matter deficiency and excess is key medicine.The main component of Rhizoma Gastrodiae is gastrodin, heat highly volatile.Rhizoma Gastrodiae and his medicine are decocted altogether and can be lost because of heat the effective ingredient of sedation and analgesia.Rhizoma Gastrodiae has calmness, analgesia, anticonvulsant action; Can increase cerebral blood flow, reduce cerebral vascular resistance, slightly shrink cerebrovascular, increase coronary vasodilator flow; Can reduce blood pressure, decreased heart rate, has protective effect to myocardial ischemia; Gastrodia elata polysaccharide has immunocompetence.While using single Rhizoma Gastrodiae or gastrodia tuber preparation, as while there is dizziness, tachypnea uncomfortable in chest, nausea and vomiting, heart beating and accelerated breathing, skin pruritus etc., drug withdrawal immediately, serious symptom person should arrive hospital therapy in time.

Cortex Periplocae: warm in nature, acrid in the mouth, hardship; Return liver, kidney, heart channel.< < Traditional Chinese Medicine in Sichuan will > >: " analgesia, except rheumatism.Control anemofrigid-damp arthralgia, the contracture of foot knee joint, bones and muscles pain." wind-damp dispelling, bone and muscle strengthening.For anemofrigid-damp arthralgia, soreness of the waist and knees, shortness of breath and palpitation, edema of lower limbs.During slender acanthopanax bark spirit processed, need cautiously, because periploca sepium cardiotonic is very strong, consumption is too much easily poisoning.Be injected in animal, can make its increased blood pressure high, about 3-20 minute can be lethal; CORTEX ACANTHOPANACIS warm in nature and, injection after blood pressure without very change.Join Radix Angelicae Pubescentis, expelling wind and dampness, effect strengthens, and is especially suitable for insufficiency of kidney-YANG, anemofrigid-damp arthralgia, soreness of waist and knee joint.Join the Cortex Eucommiae, treatment insufficiency of kidney-YANG, cold-damp arthromyodynia.Join Poria, warming YANG to promote diuresis, treatment deficiency of heart-YANG, asthma edema.Join Herba Epimedii, both can treat the sexual impotence incontinence of urine of insufficiency of kidney-YANG, can be used for again anemofrigid-damp arthralgia.Join Ootheca Mantidis, for impotence due to deficiency of the kidney, nocturnal emission kidney essense, urinates smart incontinence of urine.

Rhizoma Dioscoreae Septemlobae: property is flat, bitter in the mouth; Enter Liver Channel, stomach warp, urinary bladder channel.< < property of medicine opinion > >: " control cold wind insensitive impediment, waist foot is not pulled by, brothers are frightened, and main man's lumbago is cold for a long time, is to have bladder retained water between kidney." < < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: " control wind and cold, warming the meridian network, waist knee joint pain, stupid fiber crops all over, sharp wing dehydration channel, red white turbid urine." function dampness removing goes turbidly, blood stasis dispelling dispels the wind.Dampness removing goes turbid, wind expelling stagnation removing.For stranguria marked by chyluria, nebulousurine, leukorrhagia, rheumatic arthralgia, articular instability, lumbocrural pain.Dioscin or dioscorea sapotoxin in Shan Rhizoma Dioscoreae Septemlobae rhizome kill insecticide effect, and dioscin, a carat plug woods glycoside still have antifungic action.< < Bencao Jingshu > >: " bottom is without wet, and deficiency of YIN heated, consequently drowns and have the heeltap, pains in the penis, and lumbago due to renal deficiency, and should not take.”

Pheretima: heat clearing away, spasmolytic, diuresis, removing toxic substances.For calentura mania and irritation, infantile convulsion, cough with asthma, headache conjunctival congestion, laryngopharynx swelling and pain, urinary obstruction, Fengshi Guanjie pain, the diseases such as hemiplegia Pheretima dish.External is coated with the diseases such as erysipelas, dermatitis rhus.Lumbar injection earthworm injection 10g/kg, surveys the pre-always cerebral infarction that artery ligation causes to mongolian gerbils one and has certain preventive effect in advance, can alleviate the symptom of cerebral infarction; Mice only gavages Pheretima extract l1mg/ every day, and continuous 58d, to the sarcoma S180 transplanting.Have obvious inhibitory action, not only tumor body obviously reduces, and can extend the life cycle of mice.Routine dose toxicity is little, and headache, giddy can appear in excessive use, and blood pressure is fallen after rising, stomachache, dyspnea, digestive tract hemorrhage.Yang-energy is deficient, weakness of the spleen and stomach, the dyspnea with rapid and short breath of suffering from a deficiency of the kidney, blood deficiency can not moisten nourishing muscle and tendon arteries and veins person and should not use.

Bombyx Batryticatus: salty, pungent, flat; Return liver, lung, stomach warp.< < Sheng Nong's herbal classic > >: " main pediatric epilepsy scared, night cry, go three worms, goes out black, makes us complexion good, and the cloudy infections of man is sick." < < Compendium of Materia Medica > >: " erysipelas is had an itch for loose wind-phlegm tuberculosis, scrofula, wind syndrome of head, wind worm toothache, skin wind skin ulcer ... all incised wounds, the furuncle wind hemorrhoid that swell." Bombyx Batryticatus alcohol water-leach liquor all has hypnosis, anticonvulsant action to mice, rabbit; Its extracting solution in vivo, all have a stronger anticoagulation outward; Bombyx Batryticatus powder has good hypoglycemic activity; In vitro tests, has slight bacteriostasis to staphylococcus aureus, bacillus pyocyaneus, and the external breathing that suppresses human hepatoma cell of its alcohol extract, can be used for the treatment of rectum tumor type polyp.< < Bencao Jingshu > >: " all apoplexy locked mouth, pediatric epilepsy scared night cry, because the state of mind of having a guilty conscience is not peaceful, due to blood deficiency meridians strength is anxious, and are avoided it without exopathogen for patient.Woman's metrorrhagia, puerperal is bitterly remaining, and the non-wind and cold visitor person of entering, also should not use.”

Herba Pimpinellae thellungianae: sweet in the mouth, pungent, warm in nature; GUIXIN, kidney, lung, spleen channel.< < Shaanxi Chinese herbal medicine > >: " cold relieving lung qi dispersing, the removing toxic substances of dispeling the wind, promoting blood circulation to remove blood stasis, reducing swelling and alleviating pain." < < bulletin of Chinese materia medica > >: " treatment puerperal asthenia, sexual impotence is sterile, anemofrigid cold, cough due to fluid-retention etc." warming spleen and stomach for dispelling cold, warming the kidney to activate YANG, blood circulation promoting and blood stasis dispelling; Invigorating the spleen and benefiting QI, tranquilizing by nourishing the heart, eliminating phlegm and stopping cough.Cure mainly Keshan disease, heart reconstruction, breathes hard, cough with asthma.For coldness and pain in the epigastrium due to Deficiency and coldness of spleen and stomach, vomit, have loose bowels etc.With controlling wind-cold affecting lung, Lung Qi obstraction, cough and expectoration, uncomfortable in chest panting.Preliminary pharmacological tests proof root and herb have anticoagulant effect.Herb still can coronary artery dilator, reduce coronary resistance, has hypotensive effect, can reduce myocardial oxygen consumption.Flavonoid glycoside can strengthen the activity of cardiac muscle and cerebral tissue respiratory enzyme; Its water decoction-alcohol sedimentation preparation has obvious hypotensive effect, and has certain strong effect.

Hippocampus: Gan Wen.The effect with kidney invigorating and YANG supporting, warm promoting blood circulation, tranquillizing and allaying excitement, mass dissipating and swelling eliminating, relaxing muscles and tendons and activating QI and blood in the collateral, relieving cough and asthma.Hippocampus is warm in nature supporing yang, can promoting the flow of QI-blood by warming the meridian, the effect of invigorating blood circulation again, cure mainly suffer from a deficiency of the kidney, sexual impotence, the enuresis.Hippocampus is the rare Chinese medicine that a kind of economic worth is higher, has the medicinal functions such as building body, kidney invigorating and YANG supporting, relaxing muscles and tendons and activating QI and blood in the collateral, anti-inflammatory analgetic, tranquillizing and allaying excitement, relieving cough and asthma, particularly more effective for the neural disease for the treatment of.Hippocampus, except mainly for the manufacture of various synthetic drugs, can also directly take to be healthy and strong and cure the disease.Hippocampus can strengthen mice anoxia enduring, reduces the activity of monoamine oxidase, MAO, reduces lipid peroxidation body content in vivo.In addition, various Hippocampus extracts all have the effect of calcium channel blocker.By flowing in blocking-up calcium, the effect of neuroprotective unit.

Hollow wood: bitter in the mouth; Cool in nature.Function cures mainly: dampness removing heat clearing away; Promoting blood circulation and hemostasis.Main jaundice due to damp-heat; Rheumatic arthralgia; Asthma; Menoxenia; Traumatic hemorrhage; Cystitis; Fracture and injury.

Prawn shell: sweet in the mouth; Salty; Cool in nature.Function cures mainly: calm the nerves; Antipruritic.Main neurasthenia; Scabies; Tinea alba.

Fructus Hippophae: Fructus Hippophae and oil have very high medical value, can reduce cholesterol, allevating angina pectoris outbreak, prevents and treats the effect of coronary atherosclerotic heart disease in addition; Have and eliminate the phlegm, cough-relieving, relieving asthma and treat the effect of chronic tracheitis; Can treat gastric duodenal ulcer and dyspepsia etc., evident in efficacy to diseases such as chronic superficial gastritis, atrophic gastritis, colitis; Burn, scald, cutter burning, cold injury are had to good therapeutical effect; Cervical erosion is had to good therapeutic effect.In sea buckthorn fruit, contain 7 kinds of Endospermum chinense Benth. materials such as isorhamnetin and glucoside thereof, Quercetin, nimbecetin, the usefulness that has cough-relieving, relievings asthma and eliminate the phlegm, expand coronary vasodilator, reduce cholesterol, is usually used in treating ischemic heart desease, and treatment angina pectoris effective percentage is reached to 94%.In Fructus Hippophae, SOD active component is abundant, and every gram of sea-buchthorn fresh fruit SOD content reaches 2746.0 enzyme units, and its content is 4 times of Radix Ginseng.It can block the free radical producing because of substance in vivo peroxidating, and the generation of this free radical and human senility, disease is closely related.

Radix Rhodiolae: sweet, hardship, flat; Return lung, heart channel.Radix Rhodiolae is dry root and the rhizome of crassulaceae plants Radix Rhodiolae, and the effect of Radix Rhodiolae and effect are energy the kidney invigorating, regulate the flow of vital energy and nourish blood, and have promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, antipyretic, and the effect under leukorrhagia stopping, and the side effect of Radix Rhodiolae is not temporarily found.Radix Rhodiolae can improve sleep, blood-enriching and blood-promoting circulation, anti-cerebral anoxia, resisting fatigue, promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, change become silted up detumescence, antipyreticly bring down a fever, nourish the effects such as vigour; Be used for the treatment of traumatic injury and burn and scald outward.Research points out that Oxidation, in a lot of advancing of disease processes, playing the part of very important role, such as cancer, cardiovascular diseases, diabetes, nerve degeneration and rheumatoid arthritis etc.In traditional medicine, Radix Rhodiolae is also for treating diabetes.Relevant experiment utilizes mouse to make object, and test Radix Rhodiolae is to controlling glycemic index, ferment and the activity of some antioxidative of type-II diabetes.

Arillus Longan: < < the southern regions of the Yunnan Province book on Chinese herbal medicine > >: " nourishing blood to tranquillize the mind, long intelligence arresting sweating, appetizing strengthening the spleen." < < Quanzhou book on Chinese herbal medicine > >: " tonifying YANG QI invigorating, tonifying the spleen and stomach.Control married woman's puerperal edema, deficiency of vital energy edema, diarrhea due to hypofunction of the spleen.Invigorating the heart and spleen, " nourishing blood to tranquillize the mind.For insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency and yellow complexion.The contained sugar amount of Arillus Longan is very high, is the monosaccharide of absorption easy to digest, can be directly absorbed by the body, therefore weak anemia is worn with age, and weakness due to chronic disease, often eating a little Arillus Longans is to have very much benefiting action; Women puerperal, Arillus Longan is also that food mended in important tune.Because of iron content and vitamin B2 very abundant, can alleviate uterine contraction and the sagging sense of palace body., anemia weak for women puerperal, body void etc., available Arillus Longan adds Radix Angelicae Sinensis, Fructus Lycii, several stewed chickens of Fructus Jujubae (enucleation).Or every day edible Arillus Longan boiled egg, can promoting blood flow to regulate menstruation, promote antisecosis.Taste have phlegm-fire and humidity hysteresis to stop drink, dyspepsia, nausea and vomiting person to avoid clothes.Anemia of pregnant woman, especially First Trimester, should not take Arillus Longan, in case fetal movement and premature labor etc.In addition, because its glucose content is higher, therefore diabetics should not take more.

Herba Leonuri: bitter, pungent, be slightly cold.Return liver, pericardium channel.Function cures mainly: promoting blood flow to regulate menstruation, inducing diuresis to remove edema.For menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema oliguria; Acute nephritis edema.

Ramulus Sambuci Williamsii: have anti-inflammation, heat-clearing and toxic substances removing, expelling wind and removing dampness, promoting blood circulation and stopping pain, the effects such as synthetism of stimulating the menstrual flow, be used for the treatment of various diseases associated with inflammation, rheumatic arthritis, lumbago and skelalgia, sore swollen toxin pneumonia, appendicitis, acute cellulitis, tumor, traumatic injury, fracture etc.< < Tang materia medica > >: " main injured, reuniting the fractured tendons and bones, except pruritus due to wind pathogen, dental caries.Can be bath soup."

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

Embodiment 1 tablet

The embodiment of the present invention provides a kind of endo-medicine that is used for the treatment of wind chill blockage type cervical spondylotic radiculopathy, its dosage form is tablet, raw medicinal material by following parts by weight is made: Radix Angelicae Sinensis 25 weight portions, Herba Aristolochiae 12 weight portions, Rhizoma Chuanxiong 15 weight portions, Caulis Tinosporae 22 weight portions, Rhizoma Corydalis 15 weight portions, Resina Liquidambaris 12 weight portions, Flos Carthami 25 weight portions, Retinervus Luffae Fructus 22 weight portions, Fructus Rubi Peltati 25 weight portions, Radix Salviae Miltiorrhizae 25 weight portions, Flos Campsis 15 weight portions, Flos Narcissi chinensis 15 weight portions, Rhizoma Gastrodiae 25 weight portions, Cortex Periplocae 23 weight portions, Rhizoma Dioscoreae Septemlobae 13 weight portions, Pheretima 8 weight portions, Bombyx Batryticatus 25 weight portions, Herba Pimpinellae thellungianae 12 weight portions, Hippocampus 12 weight portions, hollow wooden 15 weight portions, prawn shell 17 weight portions, Fructus Hippophae 15 weight portions, Radix Rhodiolae 15 weight portions and Arillus Longan 15 weight portions,

Its preparation method comprises the following steps:

The first step, is mixed in proportion described each raw medicinal material, adds the ethanol that the determining alcohol with respect to 3 times of mixture qualities is 90%, and reflux 2 hours is extracted, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 2 times of described medicinal residues quality is 90% again, and reflux 2 hours, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;

Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1.5 hours, pulverizes, and sieves, and obtains 350 object micropowders;

The 3rd step, the micropowders that second step is obtained, adds microcrystalline Cellulose with respect to 0.2 times of its quality, 0.1 times of lactose, the starch of 0.2 times, sieves, mix homogeneously, granulates, dry, adds with respect to 0.025 times of magnesium stearate of micropowders quality, granulate, tabletting, makes.

Embodiment 2 syrups

The embodiment of the present invention provides a kind of endo-medicine that is used for the treatment of wind chill blockage type cervical spondylotic radiculopathy, its dosage form is syrup, raw medicinal material by following parts by weight is made: Radix Angelicae Sinensis 30 weight portions, Herba Aristolochiae 15 weight portions, Rhizoma Chuanxiong 10 weight portions, Caulis Tinosporae 15 weight portions, Rhizoma Corydalis 10 weight portions, Resina Liquidambaris 15 weight portions, Flos Carthami 30 weight portions, Retinervus Luffae Fructus 25 weight portions, Fructus Rubi Peltati 20 weight portions, Radix Salviae Miltiorrhizae 20 weight portions, Flos Campsis 10 weight portions, Flos Narcissi chinensis 20 weight portions, Rhizoma Gastrodiae 20 weight portions, Cortex Periplocae 25 weight portions, Rhizoma Dioscoreae Septemlobae 15 weight portions, Pheretima 5 weight portions, Bombyx Batryticatus 30 weight portions, Herba Pimpinellae thellungianae 10 weight portions, Hippocampus 10 weight portions, hollow wooden 10 weight portions, prawn shell 25 weight portions, Fructus Hippophae 20 weight portions, Radix Rhodiolae 10 weight portions and Arillus Longan 10 weight portions,

Its preparation method comprises the following steps:

The first step, mixes Radix Angelicae Sinensis, Herba Aristolochiae, Rhizoma Chuanxiong, Caulis Tinosporae and Rhizoma Corydalis in described ratio, use the dissolve with ethanol with respect to the determining alcohol 90% of 4 times of the mixture quality obtaining, and reflux was extracted after 3 hours, filters, and obtains the first filtrate; Filtering residue is used to the dissolve with ethanol with respect to the determining alcohol 90% of 1.5 times of the mixture quality obtaining again, and reflux was extracted after 1.5 hours, filtered, and obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8g crude drug/mL, utilize the macroporous adsorptive resins eluting that volume is 5L, first use deionized water or the distilled water eluting of 5 times of resin column volumes, with the determining alcohol of 3 times of resin column volumes, be 90% ethanol elution again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;

Second step, Retinervus Luffae Fructus, Fructus Rubi Peltati, Radix Salviae Miltiorrhizae and Cortex Periplocae are mixed in described ratio, the alcohol heating reflux adding with respect to the determining alcohol 90% of 3 times of the mixture quality obtaining extracts 2 times, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 ℃ under the condition of 65 ℃, relative density is 1.21, is dried to powder by the mastic after concentrated with spray dryer;

The 3rd step, mixes surplus stock medical material in described ratio, add the water dissolution of 3 times with respect to the mixture quality obtaining, and heating decocts 3 hours, filters; Filtering residue is used to the water dissolution of 1.5 times with respect to the mixture quality obtaining again, and heating decocts 1.5 hours, filters; Merge the filtrate of twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;

The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, and adds the water dissolution with respect to 2 times of mixture qualities, with 40% sodium hydroxide solution, regulate pH value to 7.0, stir evenly, under 6 ℃ of conditions, cold preservation is 60 hours, filter, filtrate adds the sucrose with respect to 0.3 times of the mixture quality obtaining, and stirs and dissolves, regulate pH value to 7.0, add water appropriate, stir, static 15 hours, filter fill, sterilizing, obtains syrup.

Embodiment 3 paster agent

The embodiment of the present invention provides a kind of external used medicine that is used for the treatment of wind chill blockage type cervical spondylotic radiculopathy, its dosage form is paster agent, by the raw medicinal material of following parts by weight, is made: Radix Salviae Miltiorrhizae 25 weight portions, Caulis Tinosporae 21 weight portions, Herba Leonuri 15 weight portions, Ramulus Sambuci Williamsii 12 weight portions, Fructus Rubi Peltati 12 weight portions and Rhizoma Gastrodiae 15 weight portions.

Its preparation method comprises the following steps:

The first step, mixes Radix Angelicae Sinensis, Herba Aristolochiae, Rhizoma Chuanxiong, Caulis Tinosporae and Rhizoma Corydalis in described ratio, use the dissolve with ethanol with respect to the determining alcohol 90% of 4 times of the mixture quality obtaining, and reflux was extracted after 3 hours, filters, and obtains the first filtrate; Filtering residue is used to the dissolve with ethanol with respect to the determining alcohol 90% of 1 times of the mixture quality obtaining again, and reflux was extracted after 1.5 hours, filtered, and obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8g crude drug/mL, the macroporous adsorptive resins eluting that is 5L through volume, first use deionized water or the distilled water eluting of 5 times of resin column volumes, with the determining alcohol of 3 times of resin column volumes, be 90% ethanol elution again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;

Second step, Retinervus Luffae Fructus, Fructus Rubi Peltati, Radix Salviae Miltiorrhizae and Cortex Periplocae are mixed in described ratio, the alcohol heating reflux adding with respect to the determining alcohol 90% of 3 times of the mixture quality obtaining extracts 2 times, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 ℃ under the condition of 65 ℃, relative density is 1.20, is dried to powder by the mastic after concentrated with spray dryer;

The 4th step, the powder that the first step, second step and the 3rd step are obtained mixes, and adds with respect to the rubber of 1.5 times of each raw medicinal material quality sum of described Chinese medicine, the Colophonium of 1.5 times, mixes, make coating, be coated with cream, cut off, lid lining, section, obtains described paster agent.

Toxicity test

One, acute toxicity test: 60 of application NIH mices, SPF level, male and female half and half, body weight 17～24g, carries out acute toxicity test.Mice is divided into two groups at random, and 20 every group, matched group and administration group, test front fasting 12 hours; Tablet dissolved prepared by embodiments of the invention 1 is in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 28.7 crude drugs/kg), matched group gives equivalent normal saline, administration in a day 2 times, delivery time 6 hours, after administration, Continuous Observation is 14 days, and record mice toxic reaction and death toll.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Mice oral administration gavage tablet LD50>28.7 of the present invention crude drug/kg, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention is 4.6g crude drug/day/people, becomes body weight for humans in 60KG, and average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight take 21g) oral administration gavage Chinese medicine of the present invention is quantity 745 times.Therefore Acute toxicity of the present invention is low, clinical drug safety.

Two, long term toxicity test: by the syrup of the embodiment of the present invention 2 to mice by 6.43,15.72 and 16 weeks (1.0ml/100g body weight of 36.41g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: Chinese medicine preparation of the present invention all has no significant effect indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese medicine composition of the present invention is to mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.

Three, acute skin irritation test report

1, experiment purpose: detect unguentum to the stimulation/corrosiveness of laboratory animal skin and intensity

2, materials and methods:

A. tested material: title: paster agent of the present invention

B. laboratory animal: one grade of large ear white race rabbit, 4, female, body weight 2.1-2.3k part; By Shandong medical college biology department Experimental Animal Center, provided;

C. test method:

Select the healthy family that skin is intact to exempt from 4, in test, its spinal column both sides, back were cut in first 24 hours to left and right each the about 3cm * 3cm of unhairing area by hair.During test, get on two layers of gauze that tested material 0.2ml is applied to 2.5cm * 2.5cm, be applied to a side skin of unhairing surface, oilpaper covers, immobilization with adhesive tape.Opposite side skin is as blank.Seal after 4 hours, dismantle, and clean and go residual tested material with warm water, within 1,24 and 48 hour after removing tested material, observe and smear position dermoreaction, and scoring.

3, experimental result: any erythema does not appear in laboratory animal skin, redness, inflammation phenomenon.

4, brief summary: judge according to skin irritation reaction standards of grading in < < disinfection technology standard > > (1999), ointment of the present invention belongs to nonirritant to animal skin stimulus intensity.

Four, repeatedly skin irritation test testing result of the present invention following (take unguentum as main):

(1) materials and methods

1, experimental animal feeding environment room temperature is 22 ℃ ± 2 ℃, relative humidity: 60%-70%.

2, experimental animal: Japan large ear rabbit; Animal rank: regular grade; 4, male; Body weight 2 kg-3kg.

3, animal origin: Shandong medical college biology laboratory provides

(2) method

1, test basis: Ministry of Public Health < < cosmetics health standard > > (version in 2002) " skin irritation/corrosion test " the 6.4th " repeatedly skin irritation test ".

2, sample treatment: use the paster agent of the embodiment of the present invention 3 as tested material.

3, test procedure: 24h before test, with child's hair cutter, remove the hair of back part of animal spinal column both sides, remove scope 3cm * 3cm.Get tested material unguentum 0.5mL of the present invention, spread upon on animal one side skin of unhairing, opposite side in contrast, application area 2.5cm * 2.5cm; Smear every day once, smear continuously 14d.Smear cropping at every turn, remove residual tested material.Observed result after 1h, with reference to the scoring of < < cosmetics health standard > > (version in 2002) " skin irritation/corrosion test " skin irritation reaction standards of grading.

(3) result

All animals were smeared in process at 14 days, and erythema and edema phenomenon do not appear in tested skin.Animal subject repeatedly skin irritation reacts average every day every animal integral mean value for " 0 ".

Clinical trial

Case selection: the patient who fetches the 180 routine wind chill blockage type cervical spondylotic radiculopathyes that come from the court, wherein, man's 86 examples, female's 94 examples, the age is 39-65 year, the mean age is 53.5 years old, above-mentioned 180 routine patients are divided into three experimental grouies at random, every group of 60 examples, are respectively treatment group 1, treatment group 2 and matched group, each organize patient in age, the state of an illness etc. all without significant difference.

Diagnostic criteria: Chinese medical discrimination: primary symptom: root pain, numbness and identical with impact performance, person's back distending pain is heavy, and waist knee joint epidemic disease is soft, and legs and feet knot, aversion to cold and cold limbs; Inferior disease: there is the iconography evidence of obvious hyperosteogeny and/or osteoporosis more, can companioned with headache, dizzy, tinnitus, cardiopalmus, frequently, complexion Huang is white or sallow for nocturia, and indigestion and loss of appetite lack of appetite, breathes hard, and sound is timid, and pale tongue with white fur, a little less than deep-thready pulse;

Exclusion standard: the outer pathological changes of cervical vertebra, spinal canal stenosis, cervical vertebra and intraspinal tumor, with the hematopathy of bleeding tendency, tuberculosis of bone and joint, osteomyelitis and senile osteoporosis and the serious abnormal person of heart and brain hepatic and renal function.

Therapeutic Method

Treatment group 1: the syrup of taking the embodiment of the present invention 2 is treated, each 30ml, three times on the one 7 days is a course for the treatment of, takes continuously 1-6 the course for the treatment of;

Treatment group 2: use the tablet of the embodiment of the present invention 1 and the paster agent of the embodiment of the present invention 3, take the tablet of the embodiment of the present invention 1 and treat, each three, three times on the one, paster agent once a day, 7 days is a course for the treatment of, treats continuously 1-6 the course for the treatment of;

Matched group: use JINGFUKANG KELI, each 10g, three times on the one 7 days is a course for the treatment of, treats continuously 1-6 the course for the treatment of;

Wherein, the patient's of above-mentioned each experimental group Therapeutic Method also should coordinate traction therapeutic according to state of an illness weight.

Curative effect determinate standard: cure: radiculopathy, pain and numbness disappear, bears down on one and brachial plexus nerve distraction test feminine gender, and cervical region X-ray film shows that the bent amount of physiology is normal or improves; Take a turn for the better: radiculopathy or pain and numbness take a turn for the better, bear down on one and brachial plexus nerve distraction test can be positive findings sometimes, cervical region x-ray checks that physiological camber improves or without improvement; Invalid: after treatment symptom is without alleviation or treatment, symptom increases the weight of.

Therapeutic effect

Referring to table 1 and table 2, as can be seen from Table 1, adopt treatment by Chinese herbs wind chill blockage type cervical spondylotic radiculopathy of the present invention, with respect to conventional medicament, on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt treatment by Chinese herbs wind chill blockage type cervical spondylotic radiculopathy of the present invention, with respect to conventional medicament, treating significantly shortening on the course for the treatment of.

After each experimental group of table 1 is treated respectively 6 courses for the treatment of, Clinical efficacy comparison is routine

Group	Sum	Cure	Take a turn for the better	Invalid	Effective percentage
						Treatment group 1	60	32	24	4	93.3%
Treatment group 2	60	37	23	0	100%
						Matched group	60	17	29	14	76.7%

Each experimental group of table 2 is treated respectively healing number and time comparative example (%) after 6 courses for the treatment of

Group	Sum	1-2 the course for the treatment of	3-4 the course for the treatment of	5-6 the course for the treatment of
					Treatment group 1	32	8（25%）	19（59.4%）	5（15.6%）
Treatment group 2	37	13（35.1%）	19（51.4%）	5（13.5%）
					Matched group	17	4（23.5%）	6（35.3%）	7（41.2%）

Known according to the clinical statistics in above table, that Chinese medicine composition provided by the invention has is rapid-action, effective percentage is high, determined curative effect, safe, the advantage that has no side effect; Each experimental group is cured to patient simultaneously and follow up a case by regular visits to half a year, result statistics, recurs 2 examples in 32 routine patients for the treatment of group 1, and relapse rate is 6.25%; Nothing recurrence in 37 routine patients for the treatment of group 2; In the routine patient of matched group 17, recur 5 people, relapse rate 29.4%.

Model case: Liu, man, 56 years old, neck-shoulder pain, left arm pain numbness is to forefinger, and occurs hyperpathia, X-ray film shows neck 5-6 stenosis of disc space, vertebral body front and rear edge hyperosteogeny, and legs and feet knot, aversion to cold and cold limbs, and companioned with headache, tinnitus, cardiopalmus, shallow complexion, indigestion and loss of appetite lack of appetite, sound is timid, and pale tongue with white fur, a little less than deep-thready pulse.Be diagnosed as wind chill blockage type cervical spondylotic radiculopathy, use the tablet of the embodiment of the present invention 1 and the paster agent of the embodiment of the present invention 3, take the tablet of the embodiment of the present invention 1 and treat, each three, three times on the one, paster agent once a day, within 7 days, be a course for the treatment of, treat continuously 2 courses for the treatment of, the state of an illness takes a turn for the better to some extent, continue to take 2 recoveries from illness course for the treatment of, follow up a case by regular visits to and do not recur half a year.

The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims

1. the Chinese medicine that is used for the treatment of wind chill blockage type cervical spondylotic radiculopathy, it is characterized in that, described Chinese medicine composition comprises external used medicine and endo-medicine, and described endo-medicine comprises: Radix Angelicae Sinensis, Herba Aristolochiae, Rhizoma Chuanxiong, Caulis Tinosporae, Rhizoma Corydalis, Resina Liquidambaris, Flos Carthami, Retinervus Luffae Fructus, Fructus Rubi Peltati, Radix Salviae Miltiorrhizae, Flos Campsis, Flos Narcissi chinensis, Rhizoma Gastrodiae, Cortex Periplocae, Rhizoma Dioscoreae Septemlobae, Pheretima, Bombyx Batryticatus, Herba Pimpinellae thellungianae, Hippocampus, hollow wood, prawn shell, Fructus Hippophae, Radix Rhodiolae and Arillus Longan; Described external used medicine comprises: Radix Salviae Miltiorrhizae, Caulis Tinosporae, Herba Leonuri, Ramulus Sambuci Williamsii, Fructus Rubi Peltati and Rhizoma Gastrodiae.

2. the Chinese medicine that is used for the treatment of wind chill blockage type cervical spondylotic radiculopathy according to claim 1, it is characterized in that, in described endo-medicine, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 20-30 weight portion, Herba Aristolochiae 10-15 weight portion, Rhizoma Chuanxiong 10-20 weight portion, Caulis Tinosporae 15-30 weight portion, Rhizoma Corydalis 10-20 weight portion, Resina Liquidambaris 10-15 weight portion, Flos Carthami 20-30 weight portion, Retinervus Luffae Fructus 20-25 weight portion, Fructus Rubi Peltati 20-30 weight portion, Radix Salviae Miltiorrhizae 20-30 weight portion, Flos Campsis 10-20 weight portion, Flos Narcissi chinensis 10-20 weight portion, Rhizoma Gastrodiae 20-30 weight portion, Cortex Periplocae 20-25 weight portion, Rhizoma Dioscoreae Septemlobae 10-15 weight portion, Pheretima 5-15 weight portion, Bombyx Batryticatus 20-30 weight portion, Herba Pimpinellae thellungianae 10-15 weight portion, Hippocampus 10-15 weight portion, hollow wooden 10-20 weight portion, prawn shell 10-25 weight portion, Fructus Hippophae 10-20 weight portion, Radix Rhodiolae 10-20 weight portion and Arillus Longan 10-20 weight portion,

3. the Chinese medicine that is used for the treatment of wind chill blockage type cervical spondylotic radiculopathy according to claim 1 and 2, it is characterized in that, in described endo-medicine, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 25 weight portions, Herba Aristolochiae 12 weight portions, Rhizoma Chuanxiong 15 weight portions, Caulis Tinosporae 22 weight portions, Rhizoma Corydalis 15 weight portions, Resina Liquidambaris 12 weight portions, Flos Carthami 25 weight portions, Retinervus Luffae Fructus 22 weight portions, Fructus Rubi Peltati 25 weight portions, Radix Salviae Miltiorrhizae 25 weight portions, Flos Campsis 15 weight portions, Flos Narcissi chinensis 15 weight portions, Rhizoma Gastrodiae 25 weight portions, Cortex Periplocae 23 weight portions, Rhizoma Dioscoreae Septemlobae 13 weight portions, Pheretima 8 weight portions, Bombyx Batryticatus 25 weight portions, Herba Pimpinellae thellungianae 12 weight portions, Hippocampus 12 weight portions, hollow wooden 15 weight portions, prawn shell 17 weight portions, Fructus Hippophae 15 weight portions, Radix Rhodiolae 15 weight portions and Arillus Longan 15 weight portions,

In described external used medicine, the parts by weight of each raw medicinal material are: Radix Salviae Miltiorrhizae 25 weight portions, Caulis Tinosporae 21 weight portions, Herba Leonuri 15 weight portions, Ramulus Sambuci Williamsii 12 weight portions, Fructus Rubi Peltati 12 weight portions and Rhizoma Gastrodiae 15 weight portions.

4. according to the Chinese medicine that is used for the treatment of wind chill blockage type cervical spondylotic radiculopathy described in claim 1-3 any one, it is characterized in that, in described endo-medicine, the parts by weight of each raw medicinal material are: Radix Angelicae Sinensis 30 weight portions, Herba Aristolochiae 15 weight portions, Rhizoma Chuanxiong 10 weight portions, Caulis Tinosporae 15 weight portions, Rhizoma Corydalis 10 weight portions, Resina Liquidambaris 15 weight portions, Flos Carthami 30 weight portions, Retinervus Luffae Fructus 25 weight portions, Fructus Rubi Peltati 20 weight portions, Radix Salviae Miltiorrhizae 20 weight portions, Flos Campsis 10 weight portions, Flos Narcissi chinensis 20 weight portions, Rhizoma Gastrodiae 20 weight portions, Cortex Periplocae 25 weight portions, Rhizoma Dioscoreae Septemlobae 15 weight portions, Pheretima 5 weight portions, Bombyx Batryticatus 30 weight portions, Herba Pimpinellae thellungianae 10 weight portions, Hippocampus 10 weight portions, hollow wooden 10 weight portions, prawn shell 25 weight portions, Fructus Hippophae 20 weight portions, Radix Rhodiolae 10 weight portions and Arillus Longan 10 weight portions,

In described external used medicine, the parts by weight of each raw medicinal material are: Radix Salviae Miltiorrhizae 20 weight portions, Caulis Tinosporae 25 weight portions, Herba Leonuri 20 weight portions, Ramulus Sambuci Williamsii 10 weight portions, Fructus Rubi Peltati 15 weight portions and Rhizoma Gastrodiae 10 weight portions.

5. according to the preparation method of the Chinese medicine that is used for the treatment of wind chill blockage type cervical spondylotic radiculopathy described in claim 1-4 any one, it is characterized in that, the dosage form of described endo-medicine is tablet, and its preparation method comprises the following steps:

6. according to the preparation method of the Chinese medicine that is used for the treatment of wind chill blockage type cervical spondylotic radiculopathy described in claim 1-4 any one, it is characterized in that, the dosage form of described endo-medicine is syrup, and its preparation method comprises the following steps:

7. according to the preparation method of the Chinese medicine that is used for the treatment of wind chill blockage type cervical spondylotic radiculopathy described in claim 1-4 any one, it is characterized in that, the dosage form of described external used medicine is paster agent, and its preparation method comprises the following steps: