CN105362940A - Hypolipidemic cholesterol-reducing healthcare oral solution and preparation method thereof - Google Patents

Abstract

The invention provides a hypolipidemic cholesterol-reducing healthcare oral solution. The oral solution comprises, by weight, 10-50 parts of Rhizoma alismatis, 10-20 parts of Radix rehmanniae, 10-20 parts of Poria cocos, 10-20 parts of Salvia miltiorrhiza, 10-20 parts of Codonopsis pilosula, 10-20 parts of Herba eupatorii, 10-20 parts of Gynostemma pentaphyllum, 10-20 parts of Cortex mori, 10-20 parts of loofah sponge, 10-20 parts of Cornus officinalis, 10-20 parts of Radix curcumae, 10-20 parts of Rhizoma cyperi, 10-20 parts of Radix astragali, 10-20 parts of Coix seed, 10-20 parts of Polygonum cuspidatum, 10-20 parts of hawthorn, 10-20 parts of Herba leonuri and 10-20 parts of Pyrrosia lingua. The defect that Rhizoma alismatis is slightly toxic is overcome, and Rhizoma alismatis extract can affect lipid metabolism in a body and can remarkably lower cholesterol in serum and liver. Some traditional Chinese medicinal materials having efficacy of activating blood to remove stasis and having remarkable effect on reducing lipid and serum triglyceride are added, and microcirculation can be improved; most of medicinal materials are light in taste, thereby having no influence on taste of the oral solution, so that the oral solution is easy for people to accept and can well realize efficacy of lowering lipid and reducing weight.

Description

A kind of blood fat reducing cholesterol reducing health care oral liquid and preparation method thereof

Technical field

The present invention relates to the slimming health product containing deriving from plant composition, particularly a kind of blood fat reducing cholesterol reducing health care oral liquid and preparation method thereof.

Background technology

Along with industrialized development, the change of dietary structure, the improvement of living condition, the quantity of Overweight and obesity crowd worldwide increases rapidly, and in the trend of becoming younger, become global and have a strong impact on healthy epidemic diseases, therefore, the effective method of weight-reducing of search of health has very real significance, and anti-obesity activity material is the key that people expect to solve problem of obesity always safely and effectively.Medical research also shows, Chinese medicine Rhizoma Alismatis can affect HypercholesterolemicRats, significantly can reduce the cholesterol in serum and liver.There is blood fat reducing, antibacterial, blood sugar lowering, antioxidation, and energy interference body is to the absorption of fat, promotes that the fat taken in excretes.

Weight-reducing and lipid-lowering method is a lot, there are dietetic therapy, exercise therapy, pharmacotherapy and clinical treatment etc. these methods more or less have weak point, what have also easily causes side effect, as diarrhoea, anorexia etc. and health product fat-reducing has easy to use, have no side effect, the features such as effect is remarkable, and extremely consumers.

The high speed development of Modern Urban Living, also brings a series of affluenza.Wherein " three-hypers " and obesity are the primary enemies of puzzlement people." three-hypers disease " refers to hypertension, hyperglycemia (diabetes) and hyperlipidemia.Usually along with obesity.They be modern society derive from " affluenza ", possible individualism, also may be interrelated.As: diabetes patient is easy to suffer from hypertension or hyperlipidemia simultaneously, and hyperlipidemia is the principal element of arteriosclerosis formation and development, and arteriosclerotic's blood vessel elasticity difference aggravation blood pressure raises, so the later stage all defines " three-hypers disease ".Be what has statistics about three-hypers, in the Chinese ten large causes of death, the mortality rate relevant to metabolic disease is just up to 35.7%, and the death toll relevant to " three-hypers " also accounts for 27% of total death toll.Hyperlipidemia can cause blood vessel embolism; Hypertension can cause cerebral hemorrhage and rupture of blood vessel in brain; Hyperglycemia can cause diabetes.World Health Organization (WHO) once clearly proposed, and prevented the first line of defence of cardiovascular diseases from reducing " three-hypers " exactly and controlling " three-hypers ".A lot of diabetes patient is with hyperlipemia, and therefore diabetes and hyperlipemia, people call that sister is sick usually, and think that hyperlipidemia is the secondary disease of diabetes.The diabetic of about 40% has disorders of lipid metabolism according to statistics.Be characterized in that triglyceride increases to reduce with high density lipoprotein.When the reason that diabetes cause blood fat to increase is due to diabetes patient's insufficient insulin, body lactonase activity lowers, and therefore easily blood fat increases.Diabetes itself also accompany fat, protein and water, dielectric disorder except carbohydrate metabolism disturbance simultaneously on the other hand.Often there is free fatty to mobilize out from fat depot, triglyceride and FFA concentrations in blood are increased.Type 2 diabetes mellitus people takes food too much on the one hand again, and motion is few, and impel lipid synthesis in body to increase, this is also the reason causing blood fat to increase.And fat companion's hyperlipidemia person, because Insulin receptor INSR number reduces relatively, thus produce insulin resistant, easy induced Diabetic.Blood fat increased perosn also easily causes the heart, cerebrovascular complication.

Rhizoma Alismatis, theory of Chinese medical science thinks that it is cold in nature, has effect of promoting diuresis to eliminate damp pathogen.Modern medicine study, Rhizoma Alismatis can reduce serum total cholesterol and triacylglycerol content, slows down atherogenesis; Rhizoma Alismatis and preparation modern times thereof are also used for the treatment of auditory vertigo, dyslipidemia, seminal emission, fatty liver and diabetes etc.But Rhizoma Alismatis has liver toxicity, nephrotoxicity, it is improper to take, and liver, kidney can be allowed to occur swelling and other poisoning symptoms.

Present various slimming health product, medicine spreads unchecked, but the cathartic that great majority are just simple, people is allowed to dewater in a large number, cause the huge injury of the person, therefore, the effective method of weight-reducing of search of health has very real significance, and anti-obesity activity material is the key that people expect to solve problem of obesity always safely and effectively.Traditional Chinese medicine capable of reducing weight, having advantage that is nontoxic, that can be absorbed completely by organism, is the Main way that we study.There are blood fat reducing, antibacterial, blood sugar lowering, antioxidation in present market in the urgent need to developing one, and energy interference body is to the absorption of fat, promotes the diet products that the fat taken in excretes, and has advantage that is nontoxic, that can be absorbed completely by organism.

Summary of the invention

Technical problem to be solved by this invention is, dragons and fishes jumbled together for most of diet products in present market, and most just simple cathartic, allows people dewater in a large number, cause the illusion that body weight for humans alleviates.Cause huge injury to the person, therefore, the effective method of weight-reducing of search of health has very real significance, and anti-obesity activity material is the key that people expect to solve problem of obesity always safely and effectively.Rhizoma Alismatis theory of Chinese medical science thinks that it is cold in nature, has effect of promoting diuresis to eliminate damp pathogen.Modern medicine study, Rhizoma Alismatis can reduce serum total cholesterol and triacylglycerol content, slows down atherogenesis; Add some blood circulation promoting and blood stasis dispelling, fat and serum triglycerides are all had to the Chinese crude drug of obvious reducing effect, and can microcirculation be improved, the most mouthfeel of these medical materials is light, do not affect oral liquid taste, make people be easy to accept, more can reach effect of lowering blood-fat and reducing weight preferably.

For solving above-mentioned technical barrier, the invention provides a kind of blood fat reducing cholesterol reducing health care oral liquid, in described blood fat reducing cholesterol reducing health care oral liquid, the parts by weight of various raw material are: Rhizoma Alismatis 10 ~ 50 parts, 10 ~ 20 parts, the Radix Rehmanniae, 10 ~ 20 parts, Poria, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, Herba Eupatorii 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, Cortex Mori 10 ~ 20 parts, Retinervus Luffae Fructus 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Semen Coicis 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Fructus Crataegi 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Folium Pyrrosiae 10 ~ 20 parts.

Described blood fat reducing cholesterol reducing health care oral liquid, in blood fat reducing cholesterol reducing health care oral liquid described in it, the parts by weight of various raw material can be: Rhizoma Alismatis 10 ~ 30 parts, 10 ~ 15 parts, the Radix Rehmanniae, 10 ~ 15 parts, Poria, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Radix Codonopsis 10 ~ 15 parts, Herba Eupatorii 10 ~ 15 parts, Herb Gynostemmae Pentaphylli 10 ~ 15 parts, Cortex Mori 10 ~ 15 parts, Retinervus Luffae Fructus 10 ~ 15 parts, Fructus Corni 10 ~ 15 parts, Radix Curcumae 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Semen Coicis 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Fructus Crataegi 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Folium Pyrrosiae 10 ~ 20 parts.

Described blood fat reducing cholesterol reducing health care oral liquid, in blood fat reducing cholesterol reducing health care oral liquid described in it, the parts by weight of various raw material can also compare: Rhizoma Alismatis 10 ~ 40 parts, 10 ~ 20 parts, the Radix Rehmanniae, 10 ~ 20 parts, Poria, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, Herba Eupatorii 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, Cortex Mori 10 ~ 20 parts, Retinervus Luffae Fructus 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Radix Curcumae 10 ~ 15 parts, Rhizoma Cyperi 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Semen Coicis 10 ~ 15 parts, Rhizoma Polygoni Cuspidati 10 ~ 15 parts, Fructus Crataegi 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Folium Pyrrosiae 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of blood fat reducing cholesterol reducing health care oral liquid, and the preparation process of described blood fat reducing cholesterol reducing health care oral liquid comprises following aspect:

A. the preparation of Rhizoma Alismatis is extracted;

B. by other raw material pulverizing described, immersion, heating, reflux, extract, 2 times;

C. again by the concentration of liquid medicine of surplus stock extraction;

D. concentrated medicinal liquid is mixed with the Rhizoma Alismatis prepared, be prepared into oral solutions.

In described step a, Rhizoma Alismatis can be got and put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution be merged and leaves standstill; The medicinal residues of the component raw medicinal material crossed by above-mentioned ethanol extraction again add 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by 2 extracting solution and leave standstill; Above-mentioned two kinds of extracting solution are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.35 filtrate, reclaim ethanol, obtain concentrated Rhizoma Alismatis extracting solution.

In described step b, surplus stock medicine can be cleaned roguing, dry, be ground into granule, soak 1 hour; Soaked crude drug is put in multi-function extractor and decocts with water secondary; Add up the water of medical material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds up the water of medical material 7 times amount, decocts 1 ~ 1.2 hour, gets twice decocting liquid mixing, filters.

In described step c, the filtrate of filtration can be inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount.

In described steps d, Rhizoma Alismatis extracting solution and concentrated surplus stock extracting solution can be merged, then add the potassium sorbate accounting for amalgamation liquid 0.2%, then add water, stir, set to 0 ~ 5 DEG C of deepfreezes 24 hours, cold preservation liquid is filtered, in potting bottle, ultraviolet disinfection, packs and get final product.

For solving the problems of the technologies described above, the present invention reoffers a kind of preparation method of blood fat reducing cholesterol reducing health care oral liquid, the preparation process of described blood fat reducing cholesterol reducing health care oral liquid can also be following aspect: all raw materials are put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; The medicinal residues of the component raw medicinal material crossed by above-mentioned ethanol extraction again add 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by 2 extracting solution and leave standstill; Merged by above-mentioned two kinds of extracting solution, reducing pressure after reclaiming ethanol, it is concentrated to put into concentrator, and by gained concentrated solution adjustment proportion to 1.06, decompression, then adds dextrin and be in harmonious proportion, pack after ultraviolet radiation for sterilizing and disinfecting.

In above-mentioned steps, two kinds of extracting solution are merged, after reclaiming ethanol decompression put into concentrator concentrated time, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount.

The technical problem that the present invention solves is, extractive technique of the present invention avoids the toxicity of Chinese medicine Rhizoma Alismatis, drops to minimum to human injury, and Rhizoma Alismatis extract can affect HypercholesterolemicRats, significantly can reduce the cholesterol in serum and liver.There is blood fat reducing, antibacterial, blood sugar lowering, antioxidation, and energy interference body is to the absorption of fat, promotes that the fat taken in excretes.Oral liquid of the present invention has advantage that is nontoxic, that can be absorbed completely by organism.Add some blood circulation promoting and blood stasis dispelling, fat and serum triglycerides are all had to the Chinese crude drug of obvious reducing effect, and can improve microcirculation, the most mouthfeel of these medical materials is light, does not affect oral liquid taste, makes people be easy to accept, more can reach effect of lowering blood-fat and reducing weight preferably.

Detailed description of the invention

Rhizoma Alismatis (rhizome) is one of traditional Chinese medicine.Theory of Chinese medical science thinks that it is cold in nature, has effect of promoting diuresis to eliminate damp pathogen.Modern medicine study, Rhizoma Alismatis can reduce serum total cholesterol and triacylglycerol content, slows down atherogenesis; Rhizoma Alismatis and preparation modern times thereof are also used for the treatment of auditory vertigo, dyslipidemia, seminal emission, fatty liver and diabetes etc.The fat-soluble part of Rhizoma Alismatis has obvious cholesterol reducing effect and study of anti-atherogenic effect to experimental hypercholesterolemicrabbits rabbit, by the acetas of the Alisol A be wherein separated, B and Alisol A, B, C, except alisol B, there is the cholesterol reducing effect shown.Content with 0.1% adds in the feedstuff of experimental atherosclerosis rats, and cholesterolemia can be made to decline more than 50%, wherein the strongest with the effect of Alisol A-24-acetas.The ethanol extraction of Rhizoma Alismatis, the ethyl acetate extract etc. of ethanol extract, have effect for reducing blood fat to experimental hypercholesterolemicrabbits rabbit and rat.Ethyl acetate extract is the strongest with its residual fraction effect be insoluble in acetic acid one water.Ethyl acetate extract oral 1g/kg every day, also has obvious cholesterol reducing effect to raising with the normal rat of normal diet.Prove by coordination list notation method, Alisol A has the ability suppressing mouse small intestine esterified cholesterol, and the absorbance of cholesterol in rat small intestine can be made to reduce by 34%, but does not affect linoleic absorption.

" ancient Chinese medical classics trace back Hui Ji " carries it: Zhang Zhongjing eight taste ball with Rhizoma Alismatis, Kou Zongshi amplification on Canon of Materia Medica cloud, but connect and draw osmanthus, attached etc. return with regard to kidney channel, not without his meaning.The medicine of stupid meaning Radix Rehmanniae, Fructus Corni, Poria, Cortex Moutan all kidney channel, Gu needless to say connecing of Rhizoma Alismatis is drawn then to also.Radix Aconiti Lateralis Preparata is the medicine of the right kidney gate of vitality, and Cortex Cinnamomi can mend the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, and fire is not enough mutually, and also needless to say connecing of Rhizoma Alismatis is drawn then extremely.Though only dry Rhizoma Dioscoreae solely enters meridian of Hand-TAI YIN, so its merit also can reinforcing YIN-essence, and hands lunar be that foot is former on the moon less, former existing taste, flow unhelpful? and though Rhizoma Alismatis becomes seemingly to rush down kidney, is rush down kidney heresy, non-basis of rushing down kidney also, Ju is non-, and is the kidney that rushes down extraordinary therefore WULING SAN uses Rhizoma Alismatis person? Poria also cuts down kidney heresy, namely so correction ear.Be the use Rhizoma Alismatis person of then eight taste balls non-he, lid is got it and is rushed down kidney heresy, supports the five internal organs, physical strength profiting, plays cloudy gas, the merit of tonifying deficiency." detailed outline ": Rhizoma Alismatis, gas is put down, sweet in the mouth and light, and light can oozing is let out, and abnormal smells from the patient is all thin, so diuretic and diarrhea.Taste have damp and hot, then nose heave and blurred vision tinnitus, Rhizoma Alismatis is oozed it and wets, then heat is also with going, and rusticly must to make, clearing heat in QI system is up, weather is bright refreshing, therefore Rhizoma Alismatis has foster the five internal organs, physical strength profiting, control head to revolve, the merit of clever knowledge, if clothes, fall order too for a long time, clear QI failing to ascend, Kidney-Yin latent consumption, pacify to obtain not blurred vision? Zhong Jing Dihuang Wan, with Poria, Rhizoma Alismatis person, be get the pathogen that it rushes down bladder, non-drawing connects also, ancients' tonic, doublely must rush down heresy, heresy goes then tonic capable, one ward off one entire, this is mysterious, do not know that this manages later age, single-minded in benefit, so for a long time clothes must to the evil of victory partially also.Legendary god of farming's book row Rhizoma Alismatis in top grade, duplicatus take for a long time make light of one's life by commiting suicide, light of looking unfamiliar, pottery, Soviet Union all think true, stupid steal doubt it.Rhizoma Alismatis row watery diarrhea kidney, for a long time clothes and can not, be equipped with again this siddhi, it is wrong known.

Radix Codonopsis is traditional tonic that China commonly uses, and the Radix Codonopsis that ancient times produce with area, Shangdang, Shanxi is top grade, has invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting.Modern study, Radix Codonopsis, containing various saccharides, phenols, sterol, volatile oil, scutellarein glucosid, Saponin and Alkaloid, has enhancing immunity, blood vessel dilating, blood pressure lowering, improves microcirculation, strengthens the effects such as hemopoietic function.In addition castering action is had to the leukopenia that chemotherapy radiotherapy causes.Radix Codonopsis has invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst." Bencao Congxin " is recorded: " invigorating the spleen and replenishing QI and taste, relieving thirst and restlessness.Middle feeble QI is weak, mends in order to adjust, very smooth and proper.”

Herb Gynostemmae Pentaphylli finds through modern medicine study, Herb Gynostemmae Pentaphylli principle active component is polysaccharide, flavonoid, saponins and microelement kind, its effect mainly promotes body fat class substance metabolism, nutrition human body cell, there is good detoxicating, relieving inflammation effect simultaneously, be widely used in hyperlipidemia, fatty liver, obesity, constipation, insomnia, hepatitis B, the treatment of chronic airway inflammation (pharyngolaryngitis, gastroenteritis etc.) and health care.

Poria sweet in the mouth, light, property are put down, and are used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.Poria slightly sweet flavor is put down, and enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.Can control dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The diuretic of Poria, is reached by strong activating the spleen pulmonary function, different from the Chinese medicine of other direct diuretic.For diarrhea due to hypofunction of the spleen, leukorrhagia Poria can spleen invigorating, again can eliminating dampness by diuresis, and for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, application Poria has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, Rhizoma Polygoni Cuspidati, Rhizoma Dioscoreae.Can be used as tonifying the lung spleen, control the adjuvant of the deficiency of vital energy.

Herba Eupatorii expelling summer-heat and damp, ward off dirty and in.Cure mainly and experience heat-damp in summer; Cold and heat are had a headache; Accumulate in moistening; Gastral cavity painful abdominal mass is not hungry; Nausea and vomiting; Sweet greasy in mouthful; Disappear truly. " Bencao Jingshu ": lung governing qi, lung qi pent-up, then upper orifices is closed and lower orifices are obstructed, the main Na Shuigu of stomach, stagnation of stomach-QI, then water paddy not with time and for accumulation of phlegm in the hypochondrium, Herba Chlorophyti pungent flat can eliminating stagnation stagnant, fragrance can dirt eliminating dislike, then come up all cards from recover, mostly appetizing is except disliking, and lung heat clearing expectorant, the panacea of Disperse hepatic depression also." key medicine divides agent ": Herba Chlorophyti, for expectorant except disliking, the product of loose Yu Xiejie, "Nei Jing" is quenched one's thirst treating with Herba EuPatorii, and removing the accumulation of stale pathogen is also.Lid is quenched one's thirst by pathogenic heat pent-up in stomach, blue energy removing the accumulation of stale pathogen.Known Herba Chlorophyti is solid to cleanse for merit, eliminates the intestines and stomach person also.

Semen Coicis is conventional Chinese medicine. be again the food generally, often eaten, property slightly sweet flavor is slightly cold, and has inducing diuresis to remove edema, the effect such as spleen invigorating is dried, arthralgia relieving by relaxing muscles and tendons, clearing away heat and discharging pus, is conventional damp-clearing drug.Semen Coicis is again a kind of beauty food, and normal food can keep human body skin gloss fine and smooth, eliminates acne, speckle passeris montani saturati, senile plaque, cyasma, butterfly spot, to desquamation, acne, chap, pachylosis etc. has good efficacy.The kind Renhe root of Semen Coicis can be used as medicine again and cure the disease.Li Shizhen (1518-1593 A.D.) is recorded in Compendium of Material Medica: Semen Coicis energy, and " invigorating spleen and reinforcing stomach, tonifying the lung heat clearing away, removes wind prevailing over dampness.To cook a meal food, control cold air.Decoct drink, diuresis pyretic stranguria." in recent years, a large amount of scientific researches and clinical practice prove, Semen Coicis or a kind of cancer therapy drug, and Preliminary Identification, it can reach more than 35% to the suppression ratio of cancer.

Rhizoma Polygoni Cuspidati its root medicinal, slightly warm in nature, tool promoting blood circulation to restore menstrual flow, dampness removing function, is conventionally used to treatment rheumatism, arthralgia pain, jaundice, amenorrhea, dysmenorrhea etc.Prove according to modern pharmacological research, Rhizoma Polygoni Cuspidati, containing anthraquinone analog compound and flavonoid Multiple components, can extract the polydatin etc. with component for reducing blood fat in acting in accordance with YIN YANG changes in four seasons stem.Regarding assay proves, Rhizoma Polygoni Cuspidati has the effect reducing cholesterol and triglyceride.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal puerperal, how many through water, all can be general, and only taste Radix Salviae Miltiorrhizae falls apart, and cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, and mend fresh blood, peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.

The pungent micro-hardship of Rhizoma Cyperi is sweet, and flat function cures mainly: resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type is suffered from abdominal pain, distending pain of the breast." detailed outline " carries it: loose seasonal epidemic pathogens is trembled with fear epidemic disease, and profit three is burnt, and separate six kinds of stagnation-syndromes, the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention, beriberi, only trusted subordinate, limbs, head, order, tooth, all pains of ear, ulcer sores, spits blood, hematochezia, hematuria, married woman's bleeding not during menses, the moon wait uncomfortable, before tire puerperal all kinds of diseases and ailments.

Radix Curcumae is pungent, bitter, cold.Return liver, the heart, lung meridian.Function cures mainly regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.Promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs.Control all pains of breast abdomen side of body rib, lose the heart demented, calentura coma, spit blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice." property of medicine opinion " carries it: control woman's stagnated blood epigastric pain caused by emotional factors, and cold air knot is poly-, and warm vinegar rubs and takes it.Tang Materia Medica carries it: main accumulation of blood, the therapeutic method to keep the adverse QI flowing downwards, granulation promoting, hemostasis, broken stagnant blood, stranguria with blood, hematuria, incised wound.

Retinervus Luffae Fructus is cool in nature, sweet in the mouth.Enter lung, stomach, Liver Channel.Dredging collateral, invigorates blood circulation, and dispels the wind.For arthralgia pain contracture, distending pain in the chest and hypochondrium, galactostasis." book on Chinese herbal medicine is just read ": Retinervus Luffae Fructus, enters meridians, separates pathogenic heat.Evanescence of heat then wind goes, and in network, the unlikely knot of body fluid is combined into expectorant, becomes all diseases of toxic swelling, therefore cloud removing toxic substances ear.

Herba Leonuri acrid in the mouth is bitter, cool.Invigorate blood circulation, silt of dispelling, regulating menstruation, disappear water.Treatment menoxenia, vaginal bleeding during pregnancy is had difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, and metrorrhagia and metrostaxis, rushes down blood, carbuncle skin infection at hematuria." detailed outline ": invigorate blood circulation, removing blood stasis, regulating menstruation, removing toxic substances.Control vaginal bleeding during pregnancy dystocia, placenta retention, bruise, blood wind, blood pain, metrorrhagia and metrostaxis, hematuria, rushes down blood, dysentery, infantile malnutrition, haemorrhoids, beats and flutters interior damage blood stasis, stool, urinary obstruction.

The Radix Astragali has the effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.The history of medicinal existing more than 2000 year so far of the Radix Astragali, modern study, the Radix Astragali is containing the various trace elements such as Saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.Have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.But table excess pathogen is contained, retention of dampness due to stagnation of QI, and food stagnation is stagnated, carbuncle from the beginning of or the excess syndrome such as pyretic toxicity Shang Sheng after bursting.The Radix Astragali has invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst." herbal classic " is recorded: " main carbuncle, loses skin ulcer for a long time, evacuation of pus pain relieving.Tonify deficiency, children's's all kinds of diseases and ailments." " Japan hanako materia medica " record: " help gas strengthening bone and muscle, put on flesh and enrich blood.”

The Radix Rehmanniae: the Radix Rehmanniae is also Radix Rehmanniae, the fresh or dry tuber of Scrophulariaceae herbaceos perennial Radix Rehmanniae RehmanniaglutinosaLibosch..Heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, the incised wound stasis of blood, removing heat from blood, hemostasis; The effect of Radix Rehmanniae and Radix Rehmanniae is different.Radix Rehmanniae clearing away heat and promoting production of body fluid, can stop blooding and removing heat from blood, is often for consumption of YIN caused by febrile disease, the diseases such as haematemesis, laryngopharynx swelling and pain, crimson tongue excessive thirst, a speckle dermexanthesis and nosebleed heat.Relative to Radix Rehmanniae, Radix Rehmanniae is heat clearing and blood cooling, also can promote the production of body fluid, all right yin nourishing, is used for treatment yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, crimson tongue excessive thirst, sends out the problems such as speckle dermexanthesis.The Radix Rehmanniae is cold in nature, and function is enriching yin and nourishing kidney.Not only promoting the production of body fluid to quench thirst and heat clearing and blood cooling, also have effect to metrorrhagia, menoxenia, frequent fetal movement, constipation etc., every blood system has the people of thermal burn the moon, can often take.If want to treat epidemic febrile disease, qingying decoction can be done with the Radix Rehmanniae; If the later stage for the treatment of epidemic febrile disease, because waste heat does not also disappear to the greatest extent, the Radix Rehmanniae should be used for boiling QINGHAOBIEJIATANG; In addition, contain for heat in blood poison, macule purple is black, and the serious heat of epidemic febrile disease enters the symptom of nutrient blood, can take the Sisheng Wan that the Radix Rehmanniae is made; General want YIN nourishing and the production of body fluid promoting to treat interior-heat quenches one's thirst with constipation, the once liquid soup that the Radix Rehmanniae boils should be eaten.

Cortex Mori is the root bark of moraceae plants Mulberry MorusalbaL..Main product in Anhui, Henan, Zhejiang, Jiangsu, the ground such as Hunan.Effect: eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.For lung-heat cough with asthma, the edema of the face, the diseases such as dysuria." property of medicine opinion ": make, flat.Can control lung qi dyspnea with fullness of the chest, aqueous vapor edema, main wound is exhausted, dredging water passages, and disappear aqueous vapor, and asthenia exopathogenic heat is had a headache, interior tonifying for the deficiency." Japan hanako materia medica ": temperature, in tune, the therapeutic method to keep the adverse QI flowing downwards.Expectorant is quenched the thirst, sharp intestine and small intestine, appetizing, lower food, and kill abdomen and hide worm, only cholera is vomited and diarrhoea.

Fructus Crataegi is containing multivitamin, Crataegolic acid, tartaric acid, citric acid, malic acid etc., and also containing the mineral such as flavonoid, lactone, saccharide, protein, fat and calcium, phosphorus, ferrum, contained lipolytic enzyme can promote the digestion of fat food.Promote gastric secretion and increase the functions such as gastric enzyme element.The traditional Chinese medical science is thought, Fructus Crataegi has that removing food stagnancyization is stagnant, convergence effect such as dysentery relieving, activating blood circulation to dissipate blood stasis.Cure mainly the diseases such as eating accumulation, chest and diaphragm feeling of fullness, the amenorrhea of hernia blood stasis.Containing the ingredient such as mountain terpenoid and pyrite class in Fructus Crataegi, there is significant blood vessel dilating and hypotensive effect, there is the function strengthening cardiac muscle, arrhythmia, adjusting blood lipid and cholesterol level, Fructus Crataegi has effect of activating blood circulation to dissipate blood stasis, contribute to removing local congestion state, have auxiliary curative effect to traumatic injury; Flavonoid contained by Fructus Crataegi and the substance such as vitamin C, carotene block and reduce the generation of free radical, and the immunity of energy enhancing body, has anti-aging, anticancer effect; Having in Fructus Crataegi relievings asthma reduces phlegm, the composition of anti-bacteria, treatment abdominal pain diarrhea.

Folium Pyrrosiae, medicinal middle finger Plants of Polypodiaceae Folium Pyrrosiae, latin name: FoliumPyrrosiae.Relieving stranguria by diuresis, lung heat clearing expels the heat-evil.Control and drench pain, hematuria, lithangiuria, nephritis, metrorrhagia, dysentery, cough due to lung-heat, chronic tracheitis, incised wound, carbuncle." not Lu ": " the only tired therapeutic method to keep the adverse QI flowing downwards, logical bladder is full, and mend five kinds of over strain, An Wuzang, removes aversion to wind, beneficial vital essence." 9. " book on Chinese herbal medicine is high former ": Folium Pyrrosiae, cures mainly consumptive fever pathogen person, consumptive fever is at bone, and pathogen is at skin, and the institute of lung kidney is main also.Five infirmity persons, the five liquid difficulty in urinations, dysuria also.Folium Pyrrosiae helps the vital essence of lung kidney, and upper downcrossings, crystal is moistened, then the outer key of upper orifices is all logical, changes under lung qi, then capable the and normal urination of water channel.

Fructus Corni, cure mainly pathogen cold and heat under the heart, warming middle-JIAO, by cold temperature numbness, goes three worms, for a long time clothes made light of one's life by commiting suicide reinforcing YIN-essence benefit essence, settling five organs, logical nine orifices, stop the merit of dribbling urination; Take improving eyesight, brute force for a long time all the year round.Fructus Corni, have another name called Fructus Corni, medicine Fructus Jujubae, real Fructus Jujubae, Fructus Corni, meat Fructus Jujubae etc., for China commonly uses rare Chinese medicine, applicating history is long.It is gentle with its benefit power, tonifying YANG and do not help fire, YIN nourishing and oiliness diaphragm, convergence and do not stay evil wait special efficacy like by successive dynasties medical science use.Zhang Zhongjing is that monarch has formulated " JINGUI SHENQI WAN " with Fructus Corni.According to chemical analysis, Fructus Corni contains the effective ingredient such as the stronger cornin of physiologically active, tartaric acid, gallic acid, malic acid, resin, tannin and multivitamin, having and strengthen immunity, antiinflammatory, the pharmacological action such as antibacterial, is the Herba indigoferae Pseudotinctoriae commonly used in tcm clinical practice.

Specific embodiment 1:

First Rhizoma Alismatis is prepared into concentrated solution.

Again by all the other the raw material Radix Rehmanniae, Poria, Radix Salviae Miltiorrhizae, Radix Codonopsis, Herba Eupatorii, Herb Gynostemmae Pentaphylli, Cortex Mori, Retinervus Luffae Fructus, Fructus Corni, Radix Curcumae, Rhizoma Cyperi, the Radix Astragali, Semen Coicis, Rhizoma Polygoni Cuspidati, Fructus Crataegi, Herba Leonuri, Folium Pyrrosiae extracts concentrated.

Mix two kinds of concentrated solutions and add adjuvant, high temperature or ultraviolet radiation for sterilizing and disinfecting bottling.

Specific embodiment 2:

Get Rhizoma Alismatis 5000g and put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill; The medicinal residues of the component raw medicinal material crossed by above-mentioned ethanol extraction again add 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by 2 extracting solution and leave standstill; Above-mentioned two kinds of extracting solution are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.35 filtrate, reclaim ethanol, obtain concentrated Rhizoma Alismatis extracting solution and leave standstill; By surplus stock Radix Rehmanniae 1500g, Poria 1500g, Radix Salviae Miltiorrhizae 1500g, Radix Codonopsis 2000g, Herba Eupatorii 1500g, Herb Gynostemmae Pentaphylli 2000g, Cortex Mori 1500g, Retinervus Luffae Fructus 1500g, Fructus Corni 2000g, Radix Curcumae 1500g, Rhizoma Cyperi 1500g, Radix Astragali 1500g, Semen Coicis 1500g, Rhizoma Polygoni Cuspidati 2000g, Fructus Crataegi 2000g, Herba Leonuri 2000g, Folium Pyrrosiae 2000g cleans roguing, dry, be ground into granule, soak 1 hour; Soaked crude drug is put in multi-function extractor and decocts with water secondary; Add up the water of medical material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds up the water of medical material 7 times amount, decocts 1 ~ 1.2 hour, gets twice decocting liquid mixing, filters; The filtrate of filtration inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount.Rhizoma Alismatis extracting solution and concentrated surplus stock extracting solution are merged, then add the potassium sorbate accounting for amalgamation liquid 0.2%, then add water, stir, set to 0 ~ 5 DEG C of deepfreezes 24 hours, by the filtration of cold preservation liquid, in potting bottle, ultraviolet disinfection, packs and get final product.

Specific embodiment 3:

By raw material Rhizoma Alismatis 3500g, Radix Rehmanniae 1200g, Poria 1300g, Radix Salviae Miltiorrhizae 1300g, Radix Codonopsis 1200g, Herba Eupatorii 1200g, Herb Gynostemmae Pentaphylli 1200g, Cortex Mori 1200g, Retinervus Luffae Fructus 1300g, Fructus Corni 1200g, Radix Curcumae 1300g, Rhizoma Cyperi 1300g, Radix Astragali 1300g, Semen Coicis 1300g, Rhizoma Polygoni Cuspidati 1200g, Fructus Crataegi 1300g, Herba Leonuri 1200g, Folium Pyrrosiae 1200g put it in 10 times of water gagings and soak.Drop into multi-function extractor and extract twice, first time adds 8-10 times amount soak by water 1-2 hour, and second time adds 4-8 times amount soak by water 1-2 hour, merges twice decocting liquid, filters to get filtrate; Heating is concentrated into pasty state, then adds dextrin and is in harmonious proportion, after ultraviolet radiation for sterilizing and disinfecting.

Claims (3)

1. a blood fat reducing cholesterol reducing health care oral liquid, it is characterized in that, described blood fat reducing cholesterol reducing health care oral liquid comprises the crude drug of following parts by weight: Rhizoma Alismatis 10 ~ 50 parts, 10 ~ 20 parts, the Radix Rehmanniae, 10 ~ 20 parts, Poria, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, Herba Eupatorii 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, Cortex Mori 10 ~ 20 parts, Retinervus Luffae Fructus 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Radix Curcumae 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Semen Coicis 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Fructus Crataegi 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Folium Pyrrosiae 10 ~ 20 parts.

2. blood fat reducing cholesterol reducing health care oral liquid according to claim 1, it is characterized in that, in described blood fat reducing cholesterol reducing health care oral liquid, the parts by weight of various raw material are: Rhizoma Alismatis 10 ~ 30 parts, 10 ~ 15 parts, the Radix Rehmanniae, 10 ~ 15 parts, Poria, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Radix Codonopsis 10 ~ 15 parts, Herba Eupatorii 10 ~ 15 parts, Herb Gynostemmae Pentaphylli 10 ~ 15 parts, Cortex Mori 10 ~ 15 parts, Retinervus Luffae Fructus 10 ~ 15 parts, Fructus Corni 10 ~ 15 parts, Radix Curcumae 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Semen Coicis 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, Fructus Crataegi 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Folium Pyrrosiae 10 ~ 20 parts.

3. blood fat reducing cholesterol reducing health care oral liquid according to claim 1, it is characterized in that, the ratio of weight and number of various raw material in described blood fat reducing cholesterol reducing health care oral liquid: Rhizoma Alismatis 10 ~ 40 parts, 10 ~ 20 parts, the Radix Rehmanniae, 10 ~ 20 parts, Poria, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, Herba Eupatorii 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, Cortex Mori 10 ~ 20 parts, Retinervus Luffae Fructus 10 ~ 20 parts, Fructus Corni 10 ~ 20 parts, Radix Curcumae 10 ~ 15 parts, Rhizoma Cyperi 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Semen Coicis 10 ~ 15 parts, Rhizoma Polygoni Cuspidati 10 ~ 15 parts, Fructus Crataegi 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Folium Pyrrosiae 10 ~ 15 parts.