CN103055259B - A kind of Folium Lycii lowering blood-fat and reducing weight health tea and preparation method thereof - Google Patents

Abstract

The invention provides a kind of Folium Lycii lowering blood-fat and reducing weight health tea, the parts by weight of various raw material are: Folium Lycii 100 ~ 200 parts, Rhizoma Alismatis 10 ~ 20 parts, Folium Perillae 10 ~ 20 parts, 10 ~ 20 parts, Poria, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, Herba Eupatorii 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Retinervus Luffae Fructus 10 ~ 20 parts, 10 ~ 20 parts, Semen Persicae, Radix Curcumae 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Semen Coicis 10 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts.The present invention makes the polyphenol substance in Folium Lycii convert aminoacid to as far as possible, is conducive to removing bitter taste in tea, makes it more delicious; Do not affect Folium Lycii tea taste, make people be easy to accept, more can reach effect of lowering blood-fat and reducing weight preferably.

Description

A kind of Folium Lycii lowering blood-fat and reducing weight health tea and preparation method thereof

Technical field

The present invention relates to the slimming health product containing deriving from plant composition, particularly a kind of Folium Lycii lowering blood-fat and reducing weight health tea and preparation method thereof.

Background technology

Cause fat factor a lot, as disease, heredity and bad life style etc., wherein majority is too much owing to taking in energy, causing overnutrition and the Simple Obesity caused. obesity is not only brought apparent indecency to people, also can bring out hypertension, hat sexually transmitted disease (STD), arteriosclerosis, hyperlipidemia, diabetes and fatty liver, cholelithiasis etc., the health of the mankind in serious threat, sometimes also can cause sterility and infertility. one of hot issue so Weight-reducing and lipid-lowering has become international.

Weight-reducing and lipid-lowering method is a lot, there are dietetic therapy, exercise therapy, pharmacotherapy and clinical treatment etc. these methods more or less have weak point, what have also easily causes side effect, as diarrhoea, anorexia etc. and health product external use to lose weight has easy to use, have no side effect, the features such as effect is remarkable, and extremely consumers.

Folium Lycii mainly containing betanin, carotene, ascorbic acid, linoleic acid, have the aminoacid of tens kinds of needed by human such as aspartic acid, glutamic acid, methionine, taurine, and be rich in the trace element of the multiple needed by human such as calcium Ca, ferrum Fe, zinc Zn, selenium Se, vitamin B1, vitamin B2, vitamin C.Folium Lycii tea has and alleviates frigidity, stomach invigorating, liver protecting and kidney invigorating, suppresses pulmonary tuberculosis, eliminates constipation, relieving insomnia, and conditioning hypotension, anemia, treat various ophthalmic and oral inflammation, and can skin-protecting face nursing.Long-term drink, to treat body constitution deficiency and coldness, can build up resistance especially, can play the effect of certain improvement body constitution.Folium Lycii tea has many effects, and aobvious author has three: heat clearing away, reduces blood pressure, and logical intestinal profit just.

The high speed development of Modern Urban Living, also brings a series of affluenza.Wherein " three-hypers " and obesity are the primary enemies of puzzlement people." three-hypers disease " refers to hypertension, hyperglycemia (diabetes) and hyperlipidemia.Usually along with obesity.They be modern society derive from " affluenza ", possible individualism, also may be interrelated.As: diabetes patient is easy to suffer from hypertension or hyperlipidemia simultaneously, and hyperlipidemia is the principal element of arteriosclerosis formation and development, and arteriosclerotic's blood vessel elasticity difference aggravation blood pressure raises, so the later stage all defines " three-hypers disease ".Be what has statistics about three-hypers, in the Chinese ten large causes of death, the mortality rate relevant to metabolic disease is just up to 35.7%, and the death toll relevant to " three-hypers " also accounts for 27% of total death toll.Hyperlipidemia can cause blood vessel embolism; Hypertension can cause cerebral hemorrhage and rupture of blood vessel in brain; Hyperglycemia can cause diabetes.World Health Organization (WHO) once clearly proposed, and prevented the first line of defence of cardiovascular diseases from reducing " three-hypers " exactly and controlling " three-hypers ".A lot of diabetes patient is with hyperlipemia, and therefore diabetes and hyperlipemia, people call that sister is sick usually, and think that hyperlipidemia is the secondary disease of diabetes.The diabetic of about 40% has disorders of lipid metabolism according to statistics.Be characterized in that triglyceride increases to reduce with high density lipoprotein.When the reason that diabetes cause blood fat to increase is due to diabetes patient's insufficient insulin, body lactonase activity lowers, and therefore easily blood fat increases.Diabetes itself also accompany fat, protein and water, dielectric disorder except carbohydrate metabolism disturbance simultaneously on the other hand.Often there is free fatty to mobilize out from fat depot, triglyceride and FFA concentrations in blood are increased.Type 2 diabetes mellitus people takes food too much on the one hand again, and motion is few, and impel lipid synthesis in body to increase, this is also the reason causing blood fat to increase.And fat companion's hyperlipidemia person, because Insulin receptor INSR number reduces relatively, thus produce insulin resistant, easy induced Diabetic.Blood fat increased perosn also easily causes the heart, cerebrovascular complication.

Folium Lycii, containing abundant cellulose, has catharsis relieving constipation, protects the effect of intestinal mucosa and fat-reducing.Modern scientific research proves. Folium Lycii is the natural materials that a kind of trophic structure is enriched very much, be called as natural plants nutrition library, containing multivitamin, mineral, aminoacid, tea polyphenols, alkaloid, crude protein, Plant fiber, inorganic salt, volatilization wet goods composition.The effects such as much volatile oil demonstrates antitussive, antibacterial, sterilization, antimicrobial, refreshes oneself, hypnosis, calmness.It is reported, some volatile oil also has certain antitumor action, and except for except medicine, volatile oil is also for cosmetics and tobacco business.According to pertinent literature, containing various active chemical compositions such as N mono-sugar compounds, rutin, Quercetin, volatile oil, aminoacid, electrolytes and minerals in Folium Lycii, there is blood sugar lowering, blood fat reducing, blood pressure lowering, antibacterial and antiviral multiple pharmacological effect, having wide clinical value, is a kind of natural, cheap and good-quality medicinal raw material.The compositions such as Quercetin, phenolic compound, vitamin C contained by Folium Lycii prevent oxidative damage by suppression or scavenging free radicals.According to the literature, Folium Lycii has the tonification of similar Radix Ginseng and defying age, stablizes the effect of nervous function, and what can alleviate that physiological change causes is excited, improves SOD in body active.Stop the generation of harmful substance in body, reduce or eliminate and produce and the lipofuscin in body that stagnates.Folium Lycii can improve the vigor of scavenging free radicals enzyme.Reduce the lipofuscin in tissue, slow down aging.SOD in Folium Lycii can catalysis ultra-oxygen anion free radical generation disproportionation and generate molecular oxygen and hydrogen peroxide. can scavenging free radicals in time, thus body can be protected by the injury of free radical, in flight against senium of human body, play very important effect.

Although Folium Lycii magical effect is a lot, can develop quite difficult.In product development. China greatly developed the developmental research that Folium Lycii manufactures from about 2000.A lot of Inc. produces the products such as Fructus Lycii tea, and drinking method is identical with green tea, is dissolved in boiled water or is stirred in food.But prior art makes development difficulty also high, be first exactly that existing Folium Lycii tea mouthfeel is general not good, but due to the impact of composition in Folium Lycii tea, the Folium Lycii processed through general processing technology still have a kind of unpleasant green odour and bitter taste.Be difficult to allow people accept, the processing technique of product is never effectively improved.How to accomplish dark brown breen, soup color is greenish-yellow, sweet tasty and refreshing, and sweet-smelling is permanent, improves the health-care effect of Folium Lycii, allows increasing people accept the beverage of this health, is only the huge challenge that present Folium Lycii extraction processing technology faces.

There is a lot of defect in prior art, the Folium Lycii tea mouthfeel that Folium Lycii is made is not good, and soup color contamination is ignorant, and fragrance mainly carrys out Titian by adjuvant, does not reach the requirement that conventional tea looks good, smell good and taste good.More undesirable in lowering blood-fat and reducing weight function, do not have good three-hypers and obese patient to accept.The present invention considers the making advanced technologies of Tea Processing being integrated in Folium Lycii tea, and the steam technology of completing is applied to the development of Folium Lycii tea, in conjunction with tea aroma raising technique, comprehensive every technique factor, carried out comparatively systematic research to Folium Lycii tea making, the Folium Lycii tea mouthfeel of development is good, and fragrance is high, without blue or green stink, can accept for consumption; Add some blood circulation promoting and blood stasis dispelling, fat and serum triglycerides are all had to the Chinese crude drug of obvious reducing effect, and can microcirculation be improved, the most mouthfeel of these medical materials is light, do not affect Folium Lycii tea taste, make people be easy to accept, more can reach effect of lowering blood-fat and reducing weight preferably.

For solving above-mentioned technical barrier, the invention provides a kind of Folium Lycii lowering blood-fat and reducing weight health tea, in Folium Lycii lowering blood-fat and reducing weight health tea described in it, the parts by weight of various raw material are: Folium Lycii 100 ~ 200 parts, Rhizoma Alismatis 10 ~ 20 parts, Folium Perillae 10 ~ 20 parts, 10 ~ 20 parts, Poria, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, Herba Eupatorii 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Retinervus Luffae Fructus 10 ~ 20 parts, 10 ~ 20 parts, Semen Persicae, Radix Curcumae 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Semen Coicis 10 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts.

Described Folium Lycii lowering blood-fat and reducing weight health tea, in Folium Lycii lowering blood-fat and reducing weight health tea described in it, the parts by weight of various raw material can also be preferably: Folium Lycii 100 ~ 150 parts, Rhizoma Alismatis 10 ~ 15 parts, Folium Perillae 10 ~ 15 parts, 10 ~ 15 parts, Poria, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Radix Codonopsis 10 ~ 15 parts, Herba Eupatorii 10 ~ 15 parts, Herb Gynostemmae Pentaphylli 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Retinervus Luffae Fructus 10 ~ 15 parts, 10 ~ 15 parts, Semen Persicae, Radix Curcumae 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Semen Coicis 10 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts.

Described Folium Lycii lowering blood-fat and reducing weight health tea, in Folium Lycii lowering blood-fat and reducing weight health tea described in it, the parts by weight of various raw material also can be preferably: Folium Lycii 150 ~ 200 parts, Rhizoma Alismatis 10 ~ 20 parts, Folium Perillae 10 ~ 20 parts, 10 ~ 20 parts, Poria, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, Herba Eupatorii 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Retinervus Luffae Fructus 10 ~ 20 parts, 10 ~ 20 parts, Semen Persicae, Radix Curcumae 10 ~ 15 parts, Rhizoma Cyperi 10 ~ 15 parts, Rhizoma Chuanxiong 10 ~ 15 parts, Semen Coicis 10 ~ 15 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 15 parts, Herba Patriniae 10 ~ 15 parts, Fructus Rubi 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Cortex Moutan 10 ~ 15 parts.

For solving the problems of the technologies described above, the present invention also provides the preparation method of a kind of Folium Lycii lowering blood-fat and reducing weight health tea, and the preparation method of described Folium Lycii lowering blood-fat and reducing weight health tea comprises the following steps:

A. pluck fresh Folium Lycii clean dry;

B. the Folium Lycii dried is shredded, complete;

C. knead, bake and bank up with earth;

D. Titian;

E. surplus stock is made granule;

F. pack after granule obtained above being mixed with the Folium Lycii made.

In described step a, first the free of contamination Folium Lycii of anosis worm plucked can be removed handle, put into water and rinse, after taking out, dry in the sun is on ventilative bamboo mat, and upset dry in the sun 7-12 hours, parches collection.

In described step b, the Folium Lycii that dry in the sun is good can be cut into the elongate strip that width is 1 cm, then put into the device that completes and complete, complete 30-40 minute at 80-120 DEG C.

In described step c, naturally dry in the shade after the Folium Lycii after completing can being taken out, put into large iron pan and knead, knead on first backward downwards, firmly want evenly, when filament leaf bar rope is comparatively tight, the baking machine turning in putting into 80-100 DEG C when becoming dark brown fries molding in 30-45 minute.

In described steps d, the Folium Lycii stir-fried can be dried naturally, put into fragrance extracting machine Titian 30-40 minute, temperature controls in 70-100 DEG C, naturally dries after taking out.

In described step e, surplus stock component can be put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution be merged and leaves standstill; The medicinal residues of the component raw medicinal material crossed by above-mentioned ethanol extraction again add 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by 2 extracting solution and leave standstill; Merged by above-mentioned two kinds of extracting solution, concentrating under reduced pressure relative density is the filtrate of 1.35 (80 DEG C), reclaims ethanol; by gained filtrate adjustment proportion to 1.06, reduce pressure to obtain extractum, puts into dehydrator and dry; then add Mel to be in harmonious proportion, put into granulator and make 1-2 centimetre of granule.

In described step f, fully can mix obtaining in above-mentioned steps granule with the Folium Lycii that above-mentioned steps makes, the molding of pack packaging.

The invention solves Folium Lycii tea mouthfeel not good, frangible, the shortcoming that soup color is rubescent, and make the polyphenol substance in Folium Lycii convert aminoacid to as far as possible, be conducive to removing bitter taste in tea, make it more delicious; And remaining the nutrient substance of Folium Lycii greatly, make it not have work in-process to run off, on the make avoid secondary pollution, is the tea for reducing weight and lowering fat of green health environmental protection completely.Be conducive to blue or green taste after green removing in high temperature, improve fragrance, improve mouthfeel; The present invention considers the making advanced technologies of Tea Processing being integrated in Folium Lycii tea, and the steam technology of completing is applied to the development of Folium Lycii tea, in conjunction with tea aroma raising technique, comprehensive every technique factor, carried out comparatively systematic research to Folium Lycii tea making, the Folium Lycii tea mouthfeel of development is good, and fragrance is high, without blue or green stink, can accept for consumption.Add some blood circulation promoting and blood stasis dispelling, fat and serum triglycerides are all had to the Chinese crude drug of obvious reducing effect, and can microcirculation be improved, the most mouthfeel of these medical materials is light, do not affect Folium Lycii tea taste, make people be easy to accept, more can reach effect of lowering blood-fat and reducing weight preferably.

Summary of the invention

Detailed description of the invention

Nutrient substance analysis contained by Folium Lycii: 1, the relation of calcic height and blood pressure lowering and blood fat reducing.Research proves, taking in high calcium can effectively reduce blood pressure, and Folium Lycii tea has obvious hypotensive activity, relevant with containing abundant calcium.2, abundant ferrum, zinc element can strengthen immune function of human body and enrich blood: iron content is high, be only second to deliver vegetables, mushroom, Thallus Porphyrae.Abundant ferrum is the active ingredient of enriching blood; Zn content is also very high.These two kinds of elements all have raising immune function of human body, strengthen the effect of human disease resistance.The relation of 3, abundant VE, VA and improving eyesight, anti-cancer, carotene carotene content is high, exceedes fresh carrot more than one times.Carotene can be converted into VA in human body, and VA is the important nutrient maintaining visual performance and epithelial tissue health, and its function of improving eyesight is relevant therewith, and VA has certain inhibitory action to tumor.4, glucokinin: containing abundant Folium Lycii albumen in Folium Lycii tea, test proves that Folium Lycii albumen has the anti-lipolysis of Insulin-Like, can reduce blood glucose.5, plantmilk and nourishing and fit keeping function agent: the content of Folium Lycii tea carotene exceedes fresh carrot more than one times, VE is than content 51.34mg/100g, be equivalent to 2 times of content in vegetable oil, 4 times of dry wolfberry, also containing abundant nicotinic acid, ascorbic acid, thiamine acid, riboflavin, theophylline pyrite class material etc.The interior nutrient substance containing enriching can with milk than beautiful, and many indexs also exceed milk, and people, the plantmilk of likening to of Folium Lycii tea image, drink Folium Lycii tea and equal drink milk.Japanese medicine educational circles thinks with Folium Lycii tea decoction or to get its juice be tonic invigorator.6, heat-clearing and toxic substances removing, looks improving and the skin nourishing, logical intestinal moistens just, the cool property of Folium Lycii Camellia.Toxin particularly facial in long-term drink energy purged body, has skin maintenance effect, can also treat constipation.Add appropriate crystal sugar when taking, moisten just better effects if.7, clearing heat and moistening lung, sore-throat relieving profit throat, add proper honey mouthfeel effect better.8, in abundant total amino acid content, the free amino acid that people's physical ability directly absorbs accounts for more than 50%, and containing 3% sugar, the content of 18 seed amino acids and calcium, ferrum, zinc, selenium crude protein is 2 ~ 35 times of FRUCTUS LYCII respectively after testing.

Key is in Folium Lycii containing plant sterol, flavone and isoflavone.Studies have reported that DIESF plant sterol and flavone can suppress the absorption of intestinal inner cholesterol, flavone can also reduce blood viscosity, and strengthening blood capillary, improves heart and liver function.The diuretic effect of Folium Lycii both can be urinated, and can drain moisture unnecessary in cell again, and neutral fat superfluous in blood and cholesterol are cleared, when blood neutral fat reduces, the fat of storage just discharges simultaneously.Containing more crude fibre, essential amino acid, vitamin and mineral in Folium Lycii.Therefore, Folium Lycii, while improving hyperlipemia, can prevent myocardial infarction and cerebral hemorrhage again.

Folium Lycii has the formation suppressing fatty liver, the effect reducing serum fat and suppression atherogenesis.Active component comprises DNJ, plant sterol, flavonoid etc.Containing strengthening blood capillary, the flavones ingredient reducing blood viscosity in Folium Lycii, composition in addition containing LDL-lipoprotein oxidation in antibody in Folium Lycii tea, so Folium Lycii is while fat-reducing, improving hyperlipemia, there is again the effect of prevention myocardial infarction and cerebral hemorrhage.Folium Lycii extract raises hyperlipemia serum lipids and atherosclerosis has inhibitory action.Find that Folium Lycii tea can make hyperlipidemia rats serum high-density LP (HDL-C), HDL-CTC obviously raises (p < 0.05) after deliberation, T-CHOL (TC), LDL-C, triacylglycerol (TG) obviously reduce (p < 0.05), lipid peroxide (LPO) significantly reduces (p < 0.001), illustrate that Folium Lycii can reduce blood fat, vessel softening, purged body endoperoxide, thus have inhibitory action to the rising of hyperlipemia serum lipids and atherosclerosis.

Key is in Folium Lycii containing plant sterol, flavone and isoflavone.Studies have reported that DIESF plant sterol and flavone can suppress the absorption of intestinal inner cholesterol, flavone can also reduce blood viscosity, and strengthening blood capillary, improves heart and liver function.The diuretic effect of Folium Lycii both can be urinated, and can drain moisture unnecessary in cell again, and neutral fat superfluous in blood and cholesterol are cleared, when blood neutral fat reduces, the fat of storage just discharges simultaneously.Containing more crude fibre, essential amino acid, vitamin and mineral in Folium Lycii.Therefore, Fructus Lycii, while improving hyperlipemia, can be lost weight again.

Radix Codonopsis is traditional tonic that China commonly uses, and the Radix Codonopsis that ancient times produce with area, Shangdang, Shanxi is top grade, has invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting.Modern study, Radix Codonopsis, containing various saccharides, phenols, sterol, volatile oil, scutellarein glucosid, Saponin and Alkaloid, has enhancing immunity, blood vessel dilating, blood pressure lowering, improves microcirculation, strengthens the effects such as hemopoietic function.In addition castering action is had to the leukopenia that chemotherapy radiotherapy causes.Radix Codonopsis has invigorating the spleen and replenishing QI, effect of spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst." Bencao Congxin " is recorded: " invigorating the spleen and replenishing QI and taste, relieving thirst and restlessness.Middle feeble QI is weak, mends in order to adjust, very smooth and proper.”

Herb Gynostemmae Pentaphylli finds through modern medicine study, Herb Gynostemmae Pentaphylli principle active component is polysaccharide, flavonoid, saponins and microelement kind, its effect mainly promotes body fat class substance metabolism, nutrition human body cell, there is good detoxicating, relieving inflammation effect simultaneously, be widely used in hyperlipidemia, fatty liver, obesity, constipation, insomnia, hepatitis B, the treatment of chronic airway inflammation (pharyngolaryngitis, gastroenteritis etc.) and health care.

Poria sweet in the mouth, light, property are put down, and are used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.Poria slightly sweet flavor is put down, and enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.Can control dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The diuretic of Poria, is reached by strong activating the spleen pulmonary function, different from the Chinese medicine of other direct diuretic.For diarrhea due to hypofunction of the spleen, leukorrhagia Poria can spleen invigorating, again can eliminating dampness by diuresis, and for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, application Poria has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae.Can be used as tonifying the lung spleen, control the adjuvant of the deficiency of vital energy.

Herba Eupatorii English name: Herba Eupatorii (drawing); Fortune eupatorium herb.The dry aerial parts of feverfew Herba Eupatorii Eupatorium fortunei Turcz..Herba Eupatorii expelling summer-heat and damp, ward off dirty and in.Cure mainly and experience heat-damp in summer; Cold and heat are had a headache; Accumulate in moistening; Gastral cavity painful abdominal mass is not hungry; Nausea and vomiting; Sweet greasy in mouthful; Disappear truly. " Bencao Jingshu ": lung governing qi, lung qi pent-up, then upper orifices is closed and lower orifices are obstructed, the main Na Shuigu of stomach, stagnation of stomach-QI, then water paddy not with time and for accumulation of phlegm in the hypochondrium, Herba Chlorophyti pungent flat can eliminating stagnation stagnant, fragrance can dirt eliminating dislike, then come up all cards from recover, mostly appetizing is except disliking, and lung heat clearing expectorant, the panacea of Disperse hepatic depression also." key medicine divides agent ": Herba Chlorophyti, for expectorant except disliking, the product of loose Yu Xiejie, "Nei Jing" is quenched one's thirst treating with Herba EuPatorii, and removing the accumulation of stale pathogen is also.Lid is quenched one's thirst by pathogenic heat pent-up in stomach, blue energy removing the accumulation of stale pathogen.Known Herba Chlorophyti is solid to cleanse for merit, eliminates the intestines and stomach person also.

Rhizoma Chuanxiong is pungent, temperature.Return liver, gallbladder, pericardium channel.Function blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Rhizoma Chuanxiong is warm in nature, is gynecological's common drug, has the effect of activating blood cirulation to regulate QI flow, but can not be multiplex, and especially health has the people of bleeding to be not suitable for taking, as female menstrual period.Meanwhile, Rhizoma Chuanxiong is again one of medical material conventional in medicated diet, with Gallus Domesticus with eating, can nourishing yin and activating blood, and be women's excellent tonic product.

Semen Coicis is conventional Chinese medicine. be again the food generally, often eaten, property slightly sweet flavor is slightly cold, and has inducing diuresis to remove edema, the effect such as spleen invigorating is dried, arthralgia relieving by relaxing muscles and tendons, clearing away heat and discharging pus, is conventional damp-clearing drug.Semen Coicis is again a kind of beauty food, and normal food can keep human body skin gloss fine and smooth, eliminates acne, speckle passeris montani saturati, senile plaque, cyasma, butterfly spot, to desquamation, acne, chap, pachylosis etc. has good efficacy.The kind Renhe root of Semen Coicis can be used as medicine again and cure the disease.Li Shizhen (1518-1593 A.D.) is recorded in Compendium of Material Medica: Semen Coicis energy, and " invigorating spleen and reinforcing stomach, tonifying the lung heat clearing away, removes wind prevailing over dampness.To cook a meal food, control cold air.Decoct drink, diuresis pyretic stranguria." in recent years, a large amount of scientific researches and clinical practice prove, Semen Coicis or a kind of cancer therapy drug, and Preliminary Identification, it can reach more than 35% to the suppression ratio of cancer.

Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, temperature.Return spleen, stomach warp.Cure mainly invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.The Rhizoma Atractylodis Macrocephalae has cytotoxicity to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of body antitumor reaction.Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to mice ehrlich carcinoma, lymphosarcoma ascitic type, the esophageal carcinoma (Ecal09), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Also remarkable inhibitory action is had." property of medicine opinion " carries it: monarch, and sweet in the mouth is pungent, nontoxic.Energy main large migratory arthralgia, for many years diarrhea due to disorder of qi, trusted subordinate's distending pain, the broken dyspepsia that disappears, appetizing, removes sputum, except cold and heat, lets out only.Interarea light is pleased, and preserves youthful looks, de-black.Swelling of harnessing the river is full, tells vomiting, cold type of pain in abdomen, vomits and diarrhoea incessantly, and insufficiency of stomach-QI cold-dysentery.

Radix Salviae Miltiorrhizae is bitter, is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.For costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen lumps, and skin infection swells and ache, and tumbling down is grieved, menoxenia, amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, and by " the sensible opinion of married woman " cloud, SIWU TANG controls gynecopathy, pays no attention to antenatal puerperal, how many through water, all can be general, and only taste Radix Salviae Miltiorrhizae falls apart, and cures mainly identical with it.Lid Radix Salviae Miltiorrhizae can break stagnated blood, and mend fresh blood, peaceful tire, fall stillborn fetus, only metrorrhagia dysentery, regulating menstruation arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae TANSHINONES has blood vessel dilating, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.

Rhizoma Polygonati Odorati sweet in the mouth, property is put down.Return lung; Stomach warp.Nourishing YIN and moistening the lung; Nourishing the stomach to promote the production of body fluid.Cough caused by dryness; Chronic cough; The dry throat and mouth of calentura cloudy liquid consumption wound; Interior-heat is quenched one's thirst; Deficiency of YIN diseases caused by exogenous pathogenic factor; Dizzy dizzy; Muscle arteries and veins spasm and pain.Rhizoma Polygonati Odorati sweet in the mouth greasiness, matter is soft and moisten, and is the good medicine of YIN nourishing and the production of body fluid promoting simply.Vitamin A contained in Rhizoma Polygonati Odorati, improves dry and cracked, rough skin situation, makes it soft lubrication.Play the effect of beauty and skin care." detailed outline ": " main air temperature spontaneous perspiration is scorching hot, and malaria with general debility cold and heat, taste void is weary, man's frequent micturition, and consumption of essence, all are deficient.”

Caulis Spatholobi property is bitter, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carries it can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; Flos Campsis, Caulis Spatholobi is for oral administration is that treatment blood stasis is not fallen apart, and nourishing blood is become silted up the good medicine of invigorating blood circulation.

The pungent micro-hardship of Rhizoma Cyperi is sweet, and flat function cures mainly: resolving depression of regulating the flow of vital energy, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, menoxenia, amenorrhea dysmenorrhea, colic of cold type is suffered from abdominal pain, distending pain of the breast." detailed outline " carries it: loose seasonal epidemic pathogens is trembled with fear epidemic disease, and profit three is burnt, and separate six kinds of stagnation-syndromes, the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention, beriberi, only trusted subordinate, limbs, head, order, tooth, all pains of ear, ulcer sores, spits blood, hematochezia, hematuria, married woman's bleeding not during menses, the moon wait uncomfortable, before tire puerperal all kinds of diseases and ailments.

Fructus Rubi is warm in nature; Sweet, sour; Return kidney, urinary bladder channel.Cure mainly: kidney tonifying, controlling nocturnal emission with astringent drugs, reducing urination.For enuresis due to deficiency of the kidney, frequent micturition, impotence and premature ejaculation, emission and spermatorrhea." Bencao Jingshu ": " Fructus Rubi, its main QI invigorating person, says beneficial vital essence also.Kidney storing essence, kidney improving inspiration by invigorating kidney-QI, vital essence is sufficient, then body is from light, sends out in vain also.Respectful main tonify deficiency of reviving is absolutely continuous, reinforcing YIN-essence Jianyang, smoothing skin, peace and internal organs.The main man's kidney-jing deficiency of Zhen Quan exhausts, impotence, woman's food have son.Large bright main settling five organs, beneficial color, supports vital essence, long hair, Qiang Zhi.All get its kidney tonifying and add essence, the adopted ear of sweet acid convergence." " property of medicine opinion " carry its: " main man's kidney-jing deficiency exhausts, woman's food have son.Main impotence.″

Semen Persicae is bitter, sweet, puts down the special medicine for blood stasis blood closes.Bitter to let out stagnant blood, sweet with tissue regeneration promoting blood." medicineization justice ": Semen Persicae, bitter in the mouth can rush down heat in blood, and body profit can grow dryness of the intestine.If gross weight grinds multiplex, walk Liver Channel, main broken blood-retention, water month by month, and pain all over, extremity wood numbness, left hemiplegia, left pain in foot notably, is relaxed through promoting the circulation of blood of invigorating blood circulation with it, there is the merit of eliminating blood stasis to promote regeneration of blood, if few use is mashed in peeling, enter large intestine, control blood depletion just to close, the dry dyschezia of blood, with its make moist removing heat from blood and blood, has relieving accumulation of pathogens to lead to stagnant power.

Radix Curcumae English name: Radix Curcumae (drawing); Turmeric root tuber is: the dried root of zingiberaceous plant RADIX CURCUMAE Curcuma wenyujin Y.H.Chen et C.Ling.Pungent, bitter, cold.Return liver, the heart, lung meridian.Function cures mainly regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.For amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.Promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs.Control all pains of breast abdomen side of body rib, lose the heart demented, calentura coma, spit blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice." property of medicine opinion " carries it: control woman's stagnated blood epigastric pain caused by emotional factors, and cold air knot is poly-, and warm vinegar rubs and takes it.Tang Materia Medica carries it: main accumulation of blood, the therapeutic method to keep the adverse QI flowing downwards, granulation promoting, hemostasis, broken stagnant blood, stranguria with blood, hematuria, incised wound.

Rhizoma Alismatis (rhizome) is one of traditional Chinese medicine.Theory of Chinese medical science thinks that it is cold in nature, has effect of promoting diuresis to eliminate damp pathogen.Modern medicine study, Rhizoma Alismatis can reduce serum total cholesterol and triacylglycerol content, slows down atherogenesis; Rhizoma Alismatis and preparation modern times thereof are also used for the treatment of auditory vertigo, dyslipidemia, seminal emission, fatty liver and diabetes etc.The fat-soluble part of Rhizoma Alismatis has obvious cholesterol reducing effect and study of anti-atherogenic effect to experimental hypercholesterolemicrabbits rabbit, by the acetas of the Alisol A be wherein separated, B and Alisol A, B, C, except alisol B, there is the cholesterol reducing effect shown.Content with 0.1% adds in the feedstuff of experimental atherosclerosis rats, and cholesterolemia can be made to decline more than 50%, wherein the strongest with the effect of Alisol A-24-acetas.The ethanol extraction of Rhizoma Alismatis, the ethyl acetate extract etc. of ethanol extract, have effect for reducing blood fat to experimental hypercholesterolemicrabbits rabbit and rat.Ethyl acetate extract is the strongest with its residual fraction effect be insoluble in acetic acid one water.Ethyl acetate extract oral 1g/kg every day, also has obvious cholesterol reducing effect to raising with the normal rat of normal diet.Prove by coordination list notation method, Alisol A has the ability suppressing mouse small intestine esterified cholesterol, and the absorbance of cholesterol in rat small intestine can be made to reduce by 34%, but does not affect linoleic absorption.

Retinervus Luffae Fructus English name: Retinervus Luffae Fructus (drawing); Luffavegetable sponge.It is the fiber pipe of the dry mature fruit of cucurbitaceous plant Fructus Luffae Luffa cylindrica (L.) Roem..Cool in nature, sweet in the mouth.Enter lung, stomach, Liver Channel.Dredging collateral, invigorates blood circulation, and dispels the wind.For arthralgia pain contracture, distending pain in the chest and hypochondrium, galactostasis." book on Chinese herbal medicine is just read ": Retinervus Luffae Fructus, enters meridians, separates pathogenic heat.Evanescence of heat then wind goes, and in network, the unlikely knot of body fluid is combined into expectorant, becomes all diseases of toxic swelling, therefore cloud removing toxic substances ear.

Folium Perillae expelling cold and relieving exterior syndrome, regulating the flow of QI to ease the stomach.Cure mainly cold, fever, be afraid of cold, lossless, uncomfortable in chest, cough, separates the poisoning stomachache caused of Eriocheir sinensis, diarrhoea, the diseases such as vomiting.Folium Perillae contains multiple nutritional components, is rich in carotene, vitamin C, B2 especially.Abundant carotene, vitamin C contribute to increasing immune function of human body by force, strengthen human body defending and fighting against diseases ability.Folium Perillae have deliver, cold expelling, the effect of regulating the flow of vital energy.This dish is applicable to the diseases such as cold, fever with aversion to cold, cough, asthma, distension and fullness of the chest and abdomen.Healthy People edible can building body, skin care, skin moistening, improving eyesight and vigorous and graceful.

Herba Leonuri acrid in the mouth is bitter, cool.Invigorate blood circulation, silt of dispelling, regulating menstruation, disappear water.Treatment menoxenia, vaginal bleeding during pregnancy is had difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, and metrorrhagia and metrostaxis, rushes down blood, carbuncle skin infection at hematuria." detailed outline ": invigorate blood circulation, removing blood stasis, regulating menstruation, removing toxic substances.Control vaginal bleeding during pregnancy dystocia, placenta retention, bruise, blood wind, blood pain, metrorrhagia and metrostaxis, hematuria, rushes down blood, dysentery, infantile malnutrition, haemorrhoids, beats and flutters interior damage blood stasis, stool, urinary obstruction.

Herba Patriniae heat-clearing and toxic substances removing, removing heat from blood, eliminating carbuncle evacuation of pus, stasis-dispelling and pain-killing.For acute appendicitis, the high heat of lung abscess, coughs vomiting bloody pus, pyretic toxicity skin ulcer furuncle, and furuncle pain is swollen, breast abdomen pain, appendicitis, enteritis, dysentery, puerperal abdonimal pain, dysmenorrhea.Herba Patriniae is the whole herb with root of Valerianaceae herbaceous plant Hemerocallis citrina Baroni and patrima villosa.Shennong's Herbal is classified as top grade, is conventional heat and toxic materials clearing away medicine.Its nature and flavor are pungent, bitter, be slightly cold, and have the merit of heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, stasis-dispelling and pain-killing.

The Radix Astragali has the effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.The history of medicinal existing more than 2000 year so far of the Radix Astragali, modern study, the Radix Astragali is containing the various trace elements such as Saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.Have enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.But table excess pathogen is contained, retention of dampness due to stagnation of QI, and food stagnation is stagnated, carbuncle from the beginning of or the excess syndrome such as pyretic toxicity Shang Sheng after bursting.The Radix Astragali has invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst." herbal classic " is recorded: " main carbuncle, loses skin ulcer for a long time, evacuation of pus pain relieving.Tonify deficiency, children's's all kinds of diseases and ailments." " Japan hanako materia medica " record: " help gas strengthening bone and muscle, put on flesh and enrich blood.”

Cortex Moutan is the dry root bark of ranunculaceae peony.Originate in the ground such as Anhui, Shandong.Autumn excavates root, and removing radicula, strips root bark, dry.Life is used or is fried and uses.Compendium of Material Medica: " nourishing YIN to lower pathogenic fire separates speckle poison, throat, diuresis stasis.Descendant specially controls fire mutually with yellow tiller, does not know that the merit of Cortex Moutan more wins also.Red colored person's profit, the person of spending in vain mends, and people also seldom realizes, and should distinguish it." modern study, contained paeonol and glucosides constituents in addition thereof all have antiinflammatory action; The methanolic extract of Cortex Moutan has suppression Platelet; Paeonol has the effects such as central inhibitory action and atherosclerosis, diuresis, antiulcer such as calmness, cooling, antipyretic, analgesia, spasmolytic.

Specific embodiment 1:

Select materials: pluck and do not have disease and pest, Ye great, leaf thickness, fresh and tender Folium Lycii, note not extruding when plucking, smooth is put in bamboo basket bamboo basket.

Flushing is tedded: Folium Lycii is put into clear water washing, washes away floating ash dirty, does not rub energetically, and preferably every sheet Folium Lycii is smooth, is put on bamboo mat by washed Folium Lycii and teds, and note ventilating, upset, makes it naturally parch.The dry in the sun time is at 7-12 hour.

Complete: the Folium Lycii good by dry in the sun, be cut into the filament of 1-2 centimetre, put into the pot that completes and complete, complete 30-40 minute at 70-100 DEG C.

Knead and fry: naturally dry after the Folium Lycii after completing is taken out, knead with hands, or put into large iron pan and carry out, on first backward downwards, firmly want evenly, when filament leaf bar rope is comparatively tight, the baking machine turning in putting into 80-100 DEG C when becoming dark brown fries molding in 30-45 minute.

Molding: naturally dried by the Folium Lycii stir-fried, puts into fragrance extracting machine Titian 30-40 minute, and temperature controls in 80-100 DEG C, naturally dries after taking out.

All the other raw materials are granulated: by all the other raw material Rhizoma Alismatis, Folium Perillae, Poria, Radix Salviae Miltiorrhizae, Radix Codonopsis, Herba Eupatorii, Herb Gynostemmae Pentaphylli, the Radix Astragali, Retinervus Luffae Fructus, Semen Persicae, Radix Curcumae, Rhizoma Cyperi, Rhizoma Chuanxiong, Semen Coicis, the Rhizoma Atractylodis Macrocephalae, Herba Patriniae, Fructus Rubi, Herba Leonuri, granule made by Cortex Moutan.

Packaging: by the above-mentioned granule made, the Folium Lycii good with aforementioned dry in the sun mixes, and then can pack product, can be distributed into the little tea bag of 10-15 gram, also entirety can be mixed into bag sale.

Specific embodiment 2:

Pluck the fresh and tender Folium Lycii of 1000g, Folium Lycii is put into clear water washing, wash away floating ash dirty, do not rub energetically, preferably every sheet Folium Lycii is smooth, is put on bamboo mat by washed Folium Lycii and teds, and note ventilating, upset, makes it naturally parch.Be cut into the filament of 1-2 centimetre.Complete in electric pot, complete 30-40 minute at 70-100 DEG C; Naturally, dry after Folium Lycii after completing is taken out, knead with hands, or put into large iron pan and carry out, on first backward downwards, firmly want evenly, when filament leaf bar rope is comparatively tight, when becoming dark brown, put into the baking machine turning in stir-fry molding in 30-45 minute of 80-100 DEG C.Naturally dried by the Folium Lycii stir-fried, put into fragrance extracting machine Titian 20-30 minute, temperature controls in 80-100 DEG C, naturally dries after taking out.Naturally dried by the Folium Lycii stir-fried, put into fragrance extracting machine Titian 30-45 minute, temperature controls in 80-100 degree Celsius, naturally dries after taking out.By all the other raw material Rhizoma Alismatis 100g, Folium Perillae 100g, Poria 100g, Radix Salviae Miltiorrhizae 100g, Radix Codonopsis 100g, Herba Eupatorii 100g, Herb Gynostemmae Pentaphylli 100g, Radix Astragali 100g, Retinervus Luffae Fructus 100g, Semen Persicae 100g, Radix Curcumae 100g, Rhizoma Cyperi 100g, Rhizoma Chuanxiong 100g, Semen Coicis 100g, Rhizoma Atractylodis Macrocephalae 100g, Herba Patriniae 100g, Fructus Rubi 100g, Herba Leonuri 100g, Cortex Moutan 100g, put it in 10 times amount ethanol, 2 extracting solution each 1 ~ 2 hour, are merged and leave standstill by heating and refluxing extraction 2 times; The medicinal residues of the component raw medicinal material crossed by above-mentioned ethanol extraction again add 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by 2 extracting solution and leave standstill; Above-mentioned two kinds of extracting solution are merged; concentrating under reduced pressure relative density is the filtrate of 1.35 (80 DEG C); reclaim ethanol, by gained filtrate adjustment proportion to 1.06, reduce pressure to obtain extractum; put into dehydrator to dry; then add Mel to be in harmonious proportion, put into granulator and make 1-2 centimetre of granule, the Folium Lycii tea then obtained with above-mentioned steps fully mixes; be distributed into the little tea bag of 10-15 gram, also entirety can be mixed into bag sale.The little tea bag of 10-15 gram can be distributed into, also entirety can be mixed into bag sale.

Specific embodiment 3:

Pluck 1500g Folium Lycii, Folium Lycii is put into clear water washing, wash away floating ash dirty, do not rub energetically, preferably every sheet Folium Lycii is smooth, is put on bamboo mat by washed Folium Lycii and teds, and note ventilating, upset, makes it naturally parch.Be put on bamboo mat by washed Folium Lycii and ted, note ventilating, upset, makes it naturally parch.Complete in electric pot, complete at 100 DEG C 30 minutes; Naturally, dry after Folium Lycii after completing is taken out, knead with hands, or put into large iron pan and carry out, on first backward downwards, firmly want evenly, when filament leaf bar rope comparatively tightly, the baking machine turning in putting into 120 DEG C when becoming dark brown fries molding in 30 minutes.Naturally dried by the Folium Lycii stir-fried, put into fragrance extracting machine Titian 30 minutes, temperature controls in 80 DEG C, naturally dries after taking out.Naturally dried by the Folium Lycii stir-fried, put into fragrance extracting machine Titian 30 minutes, temperature controls in 100 DEG C, naturally dries after taking out.By all the other raw material Rhizoma Alismatis 1500g, Folium Perillae 120g, Poria 150g, Radix Salviae Miltiorrhizae 120g, Radix Codonopsis 150g, Herba Eupatorii 120g, Herb Gynostemmae Pentaphylli 150g, Radix Astragali 150g, Retinervus Luffae Fructus 120g, Semen Persicae 150g, Radix Curcumae 120g, Rhizoma Cyperi 150g, Rhizoma Chuanxiong 130g, Semen Coicis 120g, Rhizoma Atractylodis Macrocephalae 150g, Herba Patriniae 100g, Fructus Rubi 100g, Herba Leonuri 120g, Cortex Moutan 130g, put it in 10 times of water gagings and soak.Drop into multi-function extractor and extract twice, first time adds 8-10 times amount soak by water 1-2 hour, and second time adds 4-8 times amount soak by water 1-2 hour, merges twice decocting liquid, filters to get filtrate; Heating is concentrated into pasty state, puts into after 80 DEG C, baking oven is dried and cools, enter in granulator and granulate after adding Mel.Then the Folium Lycii tea finished product obtained with above-mentioned steps mixes, and is distributed into the little tea bag of 10-15 gram, also entirety can be mixed into bag sale.The little tea bag of 10-15 gram can be distributed into, also entirety can be mixed into bag sale.

Pharmacological toxicity is tested

Experimental example 1: acute toxicity test of the present invention

One, test material: animal: Kunming mouse, body weight 18-25g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: Weight-reducing health-care tea of the present invention (all raw material mixing decoction 2 times merges and filters, taking liquid) is containing 0.0365mg/ml.

Two, method:

1, LD50 calculates: adopt improvement karber's method, mice is divided into 5 groups at random, often organize 10, male and female half and half, dissolve adding distil water of the present invention, are made into Cmax, by the administration of mice maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.

2, maximum tolerated dose measures (MTD value): get mice 20, each 10 of male and female.Adding distil water of the present invention is dissolved, is made into maximum concentration, by the maximum tolerated dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.

Three, result of the test:

In LD50 calculates when giving mice with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.

Experimental example 2: the result of the test of acute toxicity and long term toxicity

Acute toxicity test: give Weight-reducing health-care tea of the present invention by the disposable gavage of white mice, maximum concentration 35%, maximum gavage capacity 0.4ml/10g, dosage 14g/kg (every g medicated powder is equivalent to 10g crude drug), Continuous Observation 7 days, do not find any toxic reaction, because concentration and dosage cannot increase, therefore fail to measure the LD50 of this medicine.Maximum tolerance determination: with maximum concentration, maximum gavage capacity, mice lavage administration 3 times, 5 hours, interval, then Continuous Observation 7 days, none example is dead.Medicated powder dosage is > 42g/kg. day (every g medicated powder is equivalent to 10g crude drug), calculates 420 times of the clinical consumption per day that is equivalent to be grown up by kg body weight.

Long term toxicity test: whether produce toxic reaction for observing long-term prescription, give rat the present invention respectively and raise clothes, by adult 70 times of clinical consumption per day and 35 times (i.e. 7g/kg/ day and 3.5g/kg/ day), give continuously and feed 8 weeks, have no the behavior of rat, feed, body weight appearance extremely, with matched group ratio, routine blood test, hepatic and renal function, the change all without exception of various important organ, within the scope of institute's dosage, do not find any toxicity of the present invention.Confirmed by the acute and chronic toxicity test of animal, safety range of the present invention is comparatively large, is a kind of safe and reliable health product.

Detailed description of the invention:

At present, domestic and international appetrol market is very fiery. and external therapy of Chinese herb Weight-reducing and lipid-lowering health product is also a dark horse, sweep the country. but the research of health product fat-reducing and antihyperglycemic, large is main mainly with clinical observation on the therapeutic effect, the animal experiment study that less employing is tight, so that science is not strong, cogency is not enough.The present invention uses zoopery to carry out verification the verifying results.

1 materials and methods

1.1 material

1.1.1 laboratory animal: ICR mice 90, public 45, female 45, body weight 18-22g, Shandong Medical University's laboratory animal

Center provides.

1.1.2 tested material: lowering blood-fat and reducing weight Fructus Lycii tea of the present invention, gives Fructus Lycii tea soak of the present invention for tested group 1, and tested group 2 gives medicated powder (in the present invention medicinal boiling water soak make pasty state for subsequent use), tested group of 3 feeding Fructus Lycii tea granule of the present invention.

1.2 experimental technique

1.2.1 Weight-reducing and lipid-lowering experimental technique

Get 40 mices, be divided into 4 groups at random, often organize 10, tested group 1,2,3 gives different tested material respectively, gives tested material every day once; Matched group does not do special handling, and each group is all fed with high lipid food, quantity-unlimiting, feeds 15d. continuously and weighs subsequently, separation of serum, and surveys serum triglycerides and T-CHOL by GPO-PAP method and CHOD-PAP method respectively; Dissect mice, isolate mouse testis place fatty tissue and weigh, the body weight between comparable group, fat weight, T-CHOL and triglyceride, carrying out t inspection.

1.2.2 microcirculation experimental technique gets 50 mices, is divided into 5 groups at random, often organizes 10 (male and female half and half), and it is a little that matched group every Mus auris dextra is coated with normal saline; The every Mus auris dextra of positive group trains first HUOXUE ZHITONG GAO, give different tested material respectively for tested group 1,2,3,15min pneumoretroperitoneum injects 0.1% pentobarbital sodium 0.1ml/10g anesthetized animal, tail vein injection 0.1% epinephrine 0.1mL/10g subsequently, observes mouse right ear fine motion vein bore (Lm) immediately and 0.2mm2 blood capillary net number .t checks process experimental data.

2 results and discussion

2.1 interpretation of result

2.1.1 on the impact of Mouse Weight, fat weight compared with matched group, tested group 1 impact on Mouse Weight, fat weight little (P>0.05); Tested group of 2 pairs of Mouse Weights, fat weight have remarkable reducing effect (P<0.01); Tested group of 3 pairs of Mouse Weights, fat weight also have obvious reducing effect (P<0.05, P<0.01). illustrate that fat-reducing is mainly played a role by medicine, and the antiobesity action of medicinal liquid little (table 1).

Table 1 Folium Lycii, Chinese medicinal granule and the present invention are on the impact of Mouse Weight, fat weight

2.1.2 on the impact of mice serum triglyceride, T-CHOL compared with matched group, tested each group to the reducing effect of mice serum T-CHOL not obvious (P>0.05), but all have remarkable reducing effect (P<0.01) to serum triglycerides, illustrate tested medicinal liquid, medicated powder and the two be combined and have reducing effect (table 2) to serum triglycerides.

The impact of table 2 slender 100 on mice serum triglyceride, T-CHOL

2.1.3 on microcirculatory impact compared with matched group, tested group 1 pair mice capillary open number has showed increased (P<0.01); Tested group of 2 pairs of venule bores and capillary open number have remarkable increase (P<0.01); Tested group of 3 pairs of mice fine motions, vein bore and capillary open number all have increase (P<0.01); Illustrate tested medicinal liquid, medicated powder and the two be combined and can improve microcirculation, have function of promoting blood circulation to disperse blood clots (table 3).

Table 3 slender 100 is on the impact of mice fine motion, vein bore and capillary open number

2.2 discuss

2.2.1 the main testing index of antiobesity action and principle a. body weight; B. body fat weight (testis and perinephric fat pad).Fat-reducing principle is superabundant fats in subduction body, not merely to lose weight as standard, requires to observe fatty minimizing degree; Do not affect normal feed; Without any side effects and untoward reaction (as giddy, weak, alopecia, diarrhoea etc.). the various diseases that obesity is caused significantly is alleviated in a short time, even rehabilitation.

2.2.2 adjusting blood lipid main testing index a. T-CHOL measures; B. triglyceride determination.

2.2.3 improving micro_circulation effect Weight-reducing health articles for use multipotency plays a role by improving microcirculation. and microcirculation is viviperception mainly, conventional look-out station is bulbar Conjunctiva Microcirculation, auricular microcirculation etc., and observation index is microvascular diameter, blood capillary site counting, change around microvascular blood flow flow velocity, fluidised form, color, blood capillary.

Experimental result shows, the present invention all has obvious reducing effect to Mouse Weight, fat and serum triglycerides, and can improve microcirculation, and reducing weight and blood fat effect has been described.

Claims (9)

1. a Folium Lycii lowering blood-fat and reducing weight health tea, it is characterized in that, the raw material of Chinese medicine composition of described Folium Lycii lowering blood-fat and reducing weight health tea is made up of the various medical materials of following parts by weight: Folium Lycii 100 ~ 150 parts, Rhizoma Alismatis 10 ~ 15 parts, Folium Perillae 10 ~ 15 parts, 10 ~ 15 parts, Poria, Radix Salviae Miltiorrhizae 10 ~ 15 parts, Radix Codonopsis 10 ~ 15 parts, Herba Eupatorii 10 ~ 15 parts, Herb Gynostemmae Pentaphylli 10 ~ 15 parts, the Radix Astragali 10 ~ 15 parts, Retinervus Luffae Fructus 10 ~ 15 parts, 10 ~ 15 parts, Semen Persicae, Radix Curcumae 10 ~ 20 parts, Rhizoma Cyperi 10 ~ 20 parts, Rhizoma Chuanxiong 10 ~ 20 parts, Semen Coicis 10 ~ 20 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 20 parts, Herba Patriniae 10 ~ 20 parts, Fructus Rubi 10 ~ 20 parts, Herba Leonuri 10 ~ 20 parts, Cortex Moutan 10 ~ 20 parts.

2. a Folium Lycii lowering blood-fat and reducing weight health tea, it is characterized in that, the raw material of Chinese medicine composition of described Folium Lycii lowering blood-fat and reducing weight health tea is made up of the various medical materials of following parts by weight: Folium Lycii 150 ~ 200 parts, Rhizoma Alismatis 10 ~ 20 parts, Folium Perillae 10 ~ 20 parts, 10 ~ 20 parts, Poria, Radix Salviae Miltiorrhizae 10 ~ 20 parts, Radix Codonopsis 10 ~ 20 parts, Herba Eupatorii 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, the Radix Astragali 10 ~ 20 parts, Retinervus Luffae Fructus 10 ~ 20 parts, 10 ~ 20 parts, Semen Persicae, Radix Curcumae 10 ~ 15 parts, Rhizoma Cyperi 10 ~ 15 parts, Rhizoma Chuanxiong 10 ~ 15 parts, Semen Coicis 10 ~ 15 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 15 parts, Herba Patriniae 10 ~ 15 parts, Fructus Rubi 10 ~ 15 parts, Herba Leonuri 10 ~ 15 parts, Cortex Moutan 10 ~ 15 parts.

3. a preparation method for Folium Lycii lowering blood-fat and reducing weight health tea as claimed in claim 1 or 2, is characterized in that, comprise the following steps:

A. pluck fresh Folium Lycii clean dry;

B. the Folium Lycii dried is shredded, complete;

C. knead, bake and bank up with earth;

D. Titian;

E. surplus stock is made granule;

F. pack after granule obtained above being mixed with the Folium Lycii made.

4. the preparation method of Folium Lycii lowering blood-fat and reducing weight health tea according to claim 3, is characterized in that: in described step a, first the free of contamination Folium Lycii of anosis worm plucked is removed handle, put into water to rinse, after taking out, dry in the sun is on ventilative bamboo mat, and upset dry in the sun 7-12 hours, parches collection.

5. the preparation method of Folium Lycii lowering blood-fat and reducing weight health tea according to claim 3, it is characterized in that: in described step b, the Folium Lycii that dry in the sun is good is cut into the elongate strip that width is 1 cm, then puts into the device that completes and complete, complete 30-40 minute at 80-120 DEG C.

6. the preparation method of Folium Lycii lowering blood-fat and reducing weight health tea according to claim 3, it is characterized in that: in described step c, Folium Lycii taking-up after completing is dried in the shade afterwards naturally, put into large iron pan to knead, knead on first backward downwards, firmly want evenly, when filament leaf bar rope is comparatively tight, the baking machine turning in putting into 80-100 DEG C when becoming dark brown fries molding in 30-45 minute.

7. the preparation method of Folium Lycii lowering blood-fat and reducing weight health tea according to claim 3, it is characterized in that: in described steps d, the Folium Lycii stir-fried is dried naturally, put into fragrance extracting machine Titian 30-40 minute, temperature controls in 70-100 DEG C, naturally dries after taking out.

8. the preparation method of Folium Lycii lowering blood-fat and reducing weight health tea according to claim 3, is characterized in that: in described step e, surplus stock component puts into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, is merged by 2 extracting solution and leaves standstill; The medicinal residues of the component raw medicinal material crossed by above-mentioned ethanol extraction again add 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, are merged by 2 extracting solution and leave standstill; Above-mentioned two kinds of extracting solution are merged, when concentrating under reduced pressure relative density is 80 DEG C 1.35 filtrate, reclaim ethanol; by gained filtrate adjustment proportion to 1.06, reduce pressure to obtain extractum, puts into dehydrator and dry; then add Mel to be in harmonious proportion, put into granulator and make 1-2 centimetre of granule.

9. the preparation method of Folium Lycii lowering blood-fat and reducing weight health tea according to claim 3, is characterized in that: in described step f, fully mixing obtaining granule in step e with the Folium Lycii that above-mentioned steps makes, the molding of pack packaging.