CN104365943A - Fructus sophorae tea with effect of reducing sugar and fat and preparation method thereof - Google Patents
Fructus sophorae tea with effect of reducing sugar and fat and preparation method thereof Download PDFInfo
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Abstract
The invention provides fructus sophorae tea with the effect of reducing sugar and fat. The fructus sophorae tea comprises various raw materials in parts by weight: 10-50 parts of fructus sophorae, 10-20 parts of lotus leaf, 10-20 parts of gynostemma pentaphylla, 10-20 parts of radix rehmanniae, 10-20 parts of prunella vulgaris, 10-20 parts of trichosanthes kirilowii maxim, 10-20 parts of white gourd kernel, 10-20 parts of rhizoma polygonati, 10-20 parts of poria cocos, 10-20 parts of rhizoma atractylodis macrocephalae, 10-20 parts of radix salviae miltiorrhizae, 10-20 parts of root bark of white mulberry and 10-20 parts of scutellaria baicalensis. The fructus sophorae tea provided by the invention uses traditional Chinese medicines to reduce sugar and fat, has the advantages of no toxicity and capability of being completely absorbed by organisms, and has good medical value; by long-time drinking, the fructus sophorae tea has the effects of reducing the blood pressure and the blood fat, clearing intestinal heat, treating the haemorrhoids, softening the blood vessel, reducing cholesterol, dispelling wind and heat, moistening the large intestine, cooling the blood and relaxing the bowels; by frequent drinking, the fructus sophorae tea is also beneficial to persons with depressing mind, red eyes, tearing and dizzy and staggering feel; the ingredients of the blood can be purified and microcirculation can also be improved.
Description
Technical field
The present invention relates to the hypoglycemic health protection tea containing deriving from plant composition, particularly a kind of Fructus Sophorae tea and preparation method thereof of hypoglycemic.
Background technology
Along with the raising of people's living standard, the illness rate of China coronary heart disease crowd is also improving constantly, and sicken age is tending towards rejuvenation, and coronary heart disease has become the killer of serious threat people life.The main cause of coronary heart disease is coronary atherosclerosis, and atherosclerotic is also the one of the main reasons of other position arterial disease.Causing arteriosclerotic hazards has a lot, such as hyperlipidemia (especially hypercholesterolemia), diabetes, and hypertension is fat or overweight, smoking etc., and wherein hypercholesterolemia is the most important hazards of atherosclerotic.One of most important progress of modern medicine is exactly specify that to lower blood cholesterol (TC) especially LDL.C, can significantly reduce coronary heart disease case fatality rate.Motherland's medical science does not have the name of disease of hyperlipidemia, but about the discussion of the aspect such as symptom, the cause of disease, the interpretation of the cause, onset and process of an illness, treatment of hyperlipidemia described in have in many Gu doctor nationalitys, the people of the obesity of Hyperlipemia that what " cream people ", " fertile people " in Huangdi's Internal Classics referred to is exactly.
Day by day flourishing due to economy, the continuous lifting of modern's living standard, cause people too much have deep love for enjoy, do not notice that the life style of oneself, behavioural habits, diet are had a liking for, thus the disease caused.Society with fast rhythm lives, the operating pressure of keen competition, serious threat is caused to the physical and mental health of modern, add that long-term diet is unreasonable, that is: smart grain replaces coarse food grain completely, the agricultural chemicals remained in the absorption of a large amount of three height (high heat, high protein, higher fatty acid), more than three (anticorrisive agent is many, flavoring agent is many, hormone many) food and food, chemical fertilizer stockpiling in vivo, add air, pollution of waterhead and amount of exercise less than normal, obesity and diabetes have just become the rich man's disease of city gang.
The high speed development of Modern Urban Living, also brings a series of rich man's disease.Wherein " three is high " and obesity are the primary enemies of puzzlement people." three high diseases " refers to hypertension, hyperglycaemia (diabetes) and hyperlipemia.Usually along with obesity.They be modern society derive from " rich man's disease ", possible individualism, also may be interrelated.As: diabetes patient is easy to suffer from hypertension or hyperlipemia simultaneously, and high fat of blood is the principal element of artery sclerosis formation and development, and arteriosclerotic's blood vessel elasticity difference aggravation blood pressure raises, so the later stage all defines " three high diseases ".Be what has statistics about three height, in the Chinese ten large causes of death, the death rate relevant to metabolic disease is just up to 35.7%, and the death toll relevant to " three is high " also accounts for 27% of total death toll.High fat of blood can cause blood vessel embolism; Hypertension can cause cerebral hemorrhage and rupture of blood vessel in brain; Hyperglycaemia can cause diabetes.The World Health Organization once clearly proposed, and prevented the first line of defence of cardiovascular disease from reducing " three is high " exactly and controlling " three is high ".A lot of diabetes patient is with hyperlipidemia, and therefore diabetes and hyperlipidemia, people call that sister is sick usually, and think that high fat of blood is the secondary disease of diabetes.The diabetic of about 40% has disorders of lipid metabolism according to statistics.Be characterized in that triglycerides increases to reduce with HDL.
When the reason that diabetes cause blood fat to increase is due to diabetes patient's insufficient insulin, body lactonase activity lowers, and therefore easily blood fat increases.Diabetes itself also accompany fat, protein and water, dielectric disorder except carbohydrate metabolism disturbance simultaneously on the other hand.Often there is free fatty to mobilize out from fat depot, triglycerides and FFA concentrations in blood are increased.Diabetes B people takes food too much on the one hand again, and motion is few, and impel lipid synthesis in body to increase, this is also the reason causing blood fat to increase.And fat companion's high fat of blood person, because insulin receptor number reduces relatively, thus produce insulin resistance, easy induced Diabetic.Diabetes are a kind of syndrome due to insulin secretion, insulin action or both carbohydrate, protein and fat metabolic disturbances simultaneously caused by existing defects.Essential characteristic is that blood sugar increases, long-term damage is dysfunction and the exhaustion of various organ, comprise the vascular conditions of constantly progress, namely PVR, blind, ephrosis, renal failure, DPN companion foot ulcers, amputation and autonomic nervous function change, and also have the danger of ever-increasing cardiovascular, the cerebrovascular and peripheral angiopathy.
The fruit that Chinese scholartree is tied, popular name among the people connects beans Chinese scholartree.Chinese scholartree, summer-flowering, October fruit maturation.Pulp is yellowish light green, interior parcel black seed; Fruit is Kidney bean angular shape, has many particles that also has of individual particle to connect together, is therefore named and makes Chinese scholartree connect beans.Chinese scholartree connects beans and hangs prolongedly in the tree not fall, winter, and through frost, Exposure to Sunlight, wind, after drying, can pick, and through processing, makes Fructus Sophorae tea, drinks for people.
Fructus Sophorae tea has good medical value, drinks for a long time and can control hemorrhoid by reducing blood pressure and blood fat gut purge fire, also has softening blood vessel, norcholesterol, dispelling wind heat, profit large intestine, effect of cool blood defaecation.Ambition is unhappy, and hot eyes is shed tears, and dizzy for falling person, normal this tea of drink is quite helpful.Since permanent, North China is once being with self-control among the people richly endowed by nature from drink.
Carry according to " herbal classic ", in Fructus Sophorae master five, perverse trend heat, only saliva and spittle, mend and hinder absolutely, five hemorrhoid, fiery sore, and married woman's breast lump in the abdomen, son hides shoot.Supplement to the Herbal carries its desinsection and removes wind, and improving eyesight is except hot tears, and between brains ambition, hot blast is unhappy, and wind is dizzy for falling, and ptysis is as liquor-saturated in mind, ripples as person on ship car." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries its styptic powder subcutaneous ulcer.Control five hemorrhoid discharging fresh blood stools, red white heat rushes down dysentery." about can cure mirror " carry its clear away heart-fire, lung, spleen, liver, large intestine fire.Control trusted subordinate's heat pain." book on Chinese herbal medicine asks former " is carried its Fructus Sophorae profit liver and is nourished blood.Control infantile malnutrition due to digestive disturbances or intestinalparasites, malignant boil, bloody flux, collapse blood; Nucleon in its angle, mends brain, desinsection.
The Fructus Sophorae itself is slightly poisonous, without the process of preparing Chinese medicine directly drink be easy to cause poisoning.Our technique is nine steaming nine solarizations, its toxicity is dispelled completely, can make the relieved use of consumer.Be rich in fiber inside the Fructus Sophorae, fiber can promote intestinal peristalsis, helps defecation, reduces body inner cholesterol, and minimizing toxin, refuse accumulate in vivo, reaches prevention of stroke and the effect of preventing and treating cancer of the stomach, the cancer of the uterus.Often the edible Fructus Sophorae stimulates circulation, so be applicable to very much the working clan of long-term sitting office, remove stomach rubbish, prevent human body from crossing presenility, moist skin, preventing apoplexy and hypertension, detoxicating intestine, reduction cholesterol and blood sugar, and applicable diabetic eats for a long time.
The various health products sold on the market now, dragons and fishes jumbled together for medicine, great majority are the amusement of false propaganda, what have does not only have health-care components, also cause the huge injury of the person, therefore, search of health effective hypoglycemic method has very real significance, and hypoglycemic active material is the key that people expect to deal with problems always safely and effectively.Chinese medicine hypoglycemic, having advantage that is nontoxic, that can be absorbed completely by organism, is the Main way that we study.There are reducing blood lipid, antibacterial, hypoglycemic, antioxidation in present market in the urgent need to developing one, and energy interference body is to the absorption of fat, promotes the product that the fat taken in excretes, and has advantage that is nontoxic, that can be absorbed completely by organism.
Summary of the invention
Technical problem to be solved by this invention is, the various health products sold on the market now, dragons and fishes jumbled together for medicine, great majority are the amusement of false propaganda, what have does not only have health-care components, also cause the huge injury of the person, therefore, search of health effective hypoglycemic method has very real significance.Health protection tea of the present invention has good medical value, and drinking for a long time can reducing blood pressure and blood fat, and hemorrhoid controlled by gut purge fire, also has softening blood vessel, norcholesterol, dispelling wind heat, profit large intestine, effect of cool blood defaecation.Unhappy to ambition, hot eyes is shed tears, and dizzy for falling person, normal this tea of drink is also quite helpful.
For solving above-mentioned technical barrier, the invention provides a kind of Fructus Sophorae tea of hypoglycemic, the parts by weight of the various raw materials of Fructus Sophorae tea described in it can be: the Fructus Sophorae 10 ~ 50 parts, 10 ~ 20 parts, lotus leaf, gynostemma pentaphylla 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, selfheal 10 ~ 20 parts, snakegourd 10 ~ 20 parts, Semen Benincasae 10 ~ 20 parts, sealwort 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the bighead atractylodes rhizome 10 ~ 20 parts, the red sage root 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, the root of large-flowered skullcap 10 ~ 20 parts.
The Fructus Sophorae tea of described hypoglycemic, the parts by weight of the various raw materials of Fructus Sophorae tea described in it can also be: the Fructus Sophorae 10 ~ 30 parts, 10 ~ 15 parts, lotus leaf, gynostemma pentaphylla 10 ~ 15 parts, 10 ~ 15 parts, the dried rhizome of rehmannia, selfheal 10 ~ 15 parts, snakegourd 10 ~ 15 parts, Semen Benincasae 10 ~ 15 parts, sealwort 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the bighead atractylodes rhizome 10 ~ 20 parts, the red sage root 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, the root of large-flowered skullcap 10 ~ 20 parts.
The Fructus Sophorae tea of described hypoglycemic, the parts by weight of the various raw materials of Fructus Sophorae tea described in it also can be: the Fructus Sophorae 10 ~ 40 parts, 10 ~ 20 parts, lotus leaf, gynostemma pentaphylla 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, selfheal 10 ~ 20 parts, snakegourd 10 ~ 20 parts, Semen Benincasae 10 ~ 20 parts, sealwort 10 ~ 15 parts, 10 ~ 15 parts, Poria cocos, the bighead atractylodes rhizome 10 ~ 15 parts, the red sage root 10 ~ 15 parts, the root bark of white mulberry 10 ~ 15 parts, the root of large-flowered skullcap 10 ~ 15 parts.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Fructus Sophorae tea of hypoglycemic, and described in it, the preparation process of Fructus Sophorae tea comprises following aspect:
A. the preparation of the Fructus Sophorae;
B. by other raw material soaking ethanol described, extract 2 times;
C. again the concentration of liquid medicine that surplus stock extracts is become granule, pulvis or paste;
D. concentrated granule, pulvis or paste are mixed with the Fructus Sophorae prepared, be prepared into health protection tea.
In described step a, after can the dry Fructus Sophorae being adopted down from Chinese scholar tree midwinter, clear water is cleaned, and dries, and removing impurity and dust, be placed on food steamer, add burning hot steaming again; Steamed, dry; Such Continuous Heat steams nine times, airing nine times; When the Fructus Sophorae becomes aterrimus, after treating its drying, get honey and put into pot heating, pour in pot by the Fructus Sophorae shone after honey melts, stirring loads container after cooling and dries in the shade, and sealing saves backup.
In described step b, surplus stock can be cleaned impurity elimination, dry, be ground into particle, add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 pasty state, stand for standby use.
In described step c, pasty state concentrate can be inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Will refrigeration liquid add 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, convection drying powdered, or adds dextrin and be in harmonious proportion and make particle.
In described steps d, the powder Fructus Sophorae prepared and surplus stock can prepared or particle mix, and ultraviolet disinfection is packed and be get final product.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Fructus Sophorae tea of hypoglycemic, and when paste made by other raw materials of the Fructus Sophorae tea of described hypoglycemic, step is:
A, get other raw materials and put into ethanol and soak, heat is extracted 2 times, and becoming paste, is component 1;
B, dregs of a decoction extracting in water 3 times, thickening filtration is paste, is component 2;
C, by also 2-in-1 to component 1 and component, be condensed into medicinal extract, after ultraviolet radiation for sterilizing and disinfecting with prepare the Fructus Sophorae and merge and pack.
In described step a, raw material can be got add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating is concentrated into paste, stand for standby use, becomes component 1; In described step b, the dregs of a decoction that alcohol extract is crossed can be put into 10 times of water gagings, then put into extractor heating and boil 1 hour, filter, filtrate is for subsequent use; Filter residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filter residue adds water again, and half an hour is boiled in third time heating, filters; Three filtrates be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge leaching liquor, are condensed into pasty state, become component 2.
The technique effect that the present invention is useful is, decoction is the conventional dosage forms of the traditional Chinese medical science, and it is convenient with advantages such as disease plus-minuss to have, but decoction decocting, carries, uses inconvenience, and composition is not exclusively fried, and mouthfeel is poor, is not suitable for the Modern human populations medication custom.Because the present invention is mainly used in preventing and treating hyperlipidemia, hyperglycaemia, this disease belongs to multifactor relevant chronic disease, and the course of disease is longer, need long-term prescription just can reach good effect, thus should select to take, carry, health protection tea formula drink easy to use more can improve health-care effect.Health protection tea of the present invention has good medical value, and drinking for a long time can reducing blood pressure and blood fat, and gut purge fire, controls hemorrhoid, also has softening blood vessel, norcholesterol, dispelling wind heat, profit large intestine, effect of cool blood defaecation.Unhappy to ambition, hot eyes is shed tears, and dizzy for falling person, normal this tea of drink is also quite helpful.
Detailed description of the invention
In the Chinese ten large causes of death, the death rate relevant to metabolic disease is just up to 35.7%, and the death toll relevant to " three is high " also accounts for 27% of total death toll.High fat of blood can cause blood vessel embolism; Hypertension can cause cerebral hemorrhage and rupture of blood vessel in brain; Hyperglycaemia can cause diabetes.The World Health Organization once clearly proposed, and prevented the first line of defence of cardiovascular disease from reducing " three is high " exactly and controlling " three is high ".A lot of diabetes patient is with hyperlipidemia, and therefore diabetes and hyperlipidemia, people call that sister is sick usually, and think that high fat of blood is the secondary disease of diabetes.The diabetic of about 40% has disorders of lipid metabolism according to statistics.Be characterized in that triglycerides increases to reduce with HDL.When the reason that diabetes cause blood fat to increase is due to diabetes patient's insufficient insulin, body lactonase activity lowers, and therefore easily blood fat increases.Diabetes itself also accompany fat, protein and water, dielectric disorder except carbohydrate metabolism disturbance simultaneously on the other hand.Often there is free fatty to mobilize out from fat depot, triglycerides and FFA concentrations in blood are increased.Diabetes B people takes food too much on the one hand again, and motion is few, and impel lipid synthesis in body to increase, this is also the reason causing blood fat to increase.And fat companion's high fat of blood person, because insulin receptor number reduces relatively, thus produce insulin resistance, easy induced Diabetic.Blood fat increased perosn also easily causes the heart, cerebrovascular complication.
The Fructus Sophorae is dry flower and alabastrum, the ripening fruits of legume Chinese scholartree.For Pharmacopoeia of the People's Republic of China nineteen ninety version is recorded.Flower is claimed sophora flower by medicinal material commodity, and bud claims the sophora bud, and fruit claims the Fructus Sophorae.Fructus Sophorae bitter, cold in nature.Return liver, large intestine channel.There are clearing heat-fire, blood cooling and hemostatic functions.Have blood in stool for intestines heat, hemorrhoid swell hemorrhage, the headache of liver heat, dizzy hot eyes.
There is long history in China to the application of Chinese scholartree and cultivation.Explaining the meaning of the word the earliest just to describe in monograph " elegant " has: " Chinese scholartree has several, leaf large and black person's name rafter Chinese scholartree, closes the person's of opening name house lizard at night Chinese scholartree daytime, the thin and dark green person of leaf but the Chinese scholartree of meaning, and its function is not sayed different ... modern doctor is maximum with Chinese scholartree person ".
Be loaded in Eastern Han Dynasty's Shennong's Herbal as medicinal head, be classified as top grade, fruit claims Chinese scholartree real, i.e. the modern Fructus Sophorae.Later history tree is all on the books, beam Tao Hongjing cloud: " Chinese scholartree is to be connected many persons as well "; Northern and Southern Dynasties' thundercloud: " Chinese scholartree is real, after Fan Cai get, removes list and five sub-persons, only gets two, three sub-persons.... allly to make, break with the order of "painted-face" character in opera mallet, with black cow's milk leaching one night, steamed use "; Song's " figure is through book on Chinese herbal medicine " is carried: " Chinese scholartree is grown directly from seeds Henan Ping Ze, and the present has it everywhere.Its wood has high large person ... "; " dietetic materia medica " also carries: " the real main perverse trend of Chinese scholartree produces difficult wound absolutely.At the beginning of spring, tender leaf is also edible, main urticaria, all wind pains of tooth ".Sophora flower is first appeared in " Japan hanako materia medica " (i.e. " large bright book on Chinese herbal medicine ").Thereafter medicine book all records the successive dynasties.Bright " Bencao Pinhui Jingyao " note has: " person of not opening is good for flower " ... ancient times uses position all to refer to bud.
The Fructus Sophorae is upper cage steaming after cleaning, and steam and once shine once, steaming 9 times, shines 9 times altogether.Then put into pot by proper honey to heat, after honey melts, the Fructus Sophorae shone is poured in pot, stir after cooling and load container.
Fructus Sophorae tea glycol is good to eat, long times of aftertaste, and this tea has softening blood vessel, hypotensive, norcholesterol, dispelling wind heat, profit large intestine, effect of cool blood defaecation.Ambition is unhappy, and hot eyes is shed tears, and dizzy for falling, it is quite helpful that hemorrhoid hemorrhage person often drinks this tea.Especially to falling three fat, prevention and therapy hemorrhoid have fabulous curative effect.Heat-clearing, profit liver, cool blood, hemostasis.Control intestines diarrhea due to wind-evil blood, hemorrhoid blood, uterine bleeding, blood drenches, bloody flux, and ambition is unhappy, and wind is dizzy for falling, and the erosion of vulva is wet itches.Clear away heart-fire, lung, spleen, liver, large intestine fire.Control trusted subordinate's heat pain.Profit liver is nourished blood.Control infantile malnutrition due to digestive disturbances or intestinalparasites, malignant boil, bloody flux, collapse blood; Nucleon in its angle, mends brain, desinsection.
The red sage root is bitter, is slightly cold.The thoughts of returning home, Liver Channel.Stasis-dispelling and pain-killing, activating blood to promote menstruation, clear away heart-fire relieving restlessness.For irregular menstruation, through closing dysmenorrhoea, a lump in the abdomen causing distension and pain, and chest ventral spine pain, hot numbness pain, sore swells and ache, dysphoria and insomnia.For sternal rib hypochondriac pain, arthralgia due to wind-dampness, abdominal mass lumps, and sore swells and ache, fall fall forward grieved, irregular menstruation, through closing dysmenorrhoea, postpartum stasis of blood pain etc.Treatment sternal rib pain, abdominal mass caking, and irregular menstruation, through amenorrhoea pain, there is good effect." detailed outline " carries: the red sage root, and by " the sensible opinion of married woman " cloud, gynecopathy controlled by Siwu Tang, pays no attention to antenatal postpartum, how many through water, all can be general, and the only taste red sage root falls apart, and cures mainly identical with it.The lid red sage root can break place blood, mends new blood, peaceful tire, and fall stillborn foetus, only metrorrhagia stagnant under, menstruation regulating arteries and veins.Main Compositions of Radix Salviae Miltiorrhizae tanshinone has hemangiectasis, improves circulation, removes the effects such as intravascular coagulation, has effect of invigorating blood circulation trace, and can promote that liver blood circulates, be beneficial to liver cell regeneration.
Bighead atractylodes rhizome bitter, sweet, temperature.Return spleen, stomach warp.Cure mainly strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive.Few for insufficiency of the spleen food, abdominal distension is had loose bowels, and phlegm and retained fluid is dizzy throbs with fear, oedema, spontaneous perspiration, fetal irritability.The bighead atractylodes rhizome has CDCC to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of the antitumor reaction of body.Baizhu volatile oil has inhibitory action to mouse EC, lymphosarcoma ascitic type, the cancer of the esophagus (Eca109), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Also remarkable inhibitory action is had." property of medicine opinion " carries it: monarch, taste is sweet, pungent, nontoxic.Energy main large wandering arthritis, for many years diarrhea due to disorder of qi, trusted subordinate's distending pain, the broken place food that disappears, appetizing, removes sputum, except fever and chills, lets out under stopping.Interarea light is pleased, and preserves youthful looks, de-black.Swelling of harnessing the river is full, tells to vomit inverse, and crymodynia in abdomen, vomits and diarrhoea incessantly, and the cold dysentery of stomach Qi deficiency.
The root bark of white mulberry is the root skin of moraceae plants mulberry Morus alba L..Main product in Anhui, Henan, Zhejiang, Jiangsu, the ground such as Hunan.Effect: removing heat from lung and relieving asthma, inducing diuresis for removing edema.Cough for lung heat and breathe heavily, the edema of the face, the diseases such as difficult urination." property of medicine opinion ": make, flat.Can control lung qi breathes heavily full, aqueous vapor edema, and main wound is exhausted, dredging water passages, and disappear aqueous vapor, the headache of consumptive disease visitor heat, interior tonifying for the deficiency." Japan hanako materia medica ": temperature, in tune, lower gas.Dissolving phlegm is quenched the thirst, sharp intestine and small intestine, appetizing, lower food, and kill abdomen and hide worm, only cholera is vomited and diarrhoea.
Snakegourd sweetness and bitterness, cold.Enter lung, stomach two warp.Function cures mainly: moistening lung, reduces phlegm, dissipating bind, ease constipation.Control phlegm-heat cough, the obstruction of qi in the chest, accumulation of pathogens in chest, consumptive lung disease hemoptysis, quenches one's thirst, jaundice, constipation, carbuncle swollen from the beginning of." product remittance essence is wanted ": " disappear knot phlegm, loose carbuncle poison." " detailed outline ": " moistening lung is dry, falls fire.Control cough, wash phlegm knot, throat, subduing inflammation sore." " Records of Tradition Chinese and Western Medicine in Combination ": " and snakegourd, can open between chest and the hot phlegm of appetite, therefore Zhong Jing controls breast knot little sunken chest soup, snakegourd with connect, Xia Bingyong; Control the obstruction of qi in the chest and have the side such as snakegourd Longstamen Onion Bulb, snakegourd and Chinese onion, wine, osmanthus, plain all medicines using.If use same with naze, be apt to control acute mastitis; If use same with ochre, kind antiemetic nosebleed; If but use its skin, can clearing lung-heat, astringe the lung, relieve coughing, Dingchuan; If but use its flesh, kind enriching yin, moisturize, sliding phlegm, to promote the production of body fluid; If but use its benevolence, it is opened chest and falls the power of stomach comparatively greatly, and kind diuresis.”
Poria cocos taste is sweet, light, property is put down, and is used as medicine and has the function of clearing damp and promoting diuresis, beneficial spleen and stomach, antitoxic heart-soothing and sedative.Modern medicine study: Poria cocos energy enhanced machine body immunity function, pachymaran has significantly antitumor and protect the liver dirty effect.Poria cocos slightly sweet flavor is put down, and enters the heart, lung, the spleen channel.There is eliminating dampness and diuresis, strengthening the spleen and stomach, effect of antitoxic heart-soothing and sedative.Can control difficult urination, oedema turgor, phlegm and retained fluid is coughed inverse, vomits inverse, and vomiting during early pregnancy, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The Li Shui of Poria cocos, is reached by strong fortune spleen PFT, different from the Chinese medicine of other direct Li Shui.For splenasthenic diarrhea, the lower Poria cocos of band can invigorating the spleen, again can excreting dampness, and for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, being with down, application Poria cocos has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the bighead atractylodes rhizome, Chinese yam.Can be used as tonifying lung spleen, control the adjuvant of the deficiency of vital energy.
The dried rhizome of rehmannia: the dried rhizome of rehmannia is also radix rehmanniae recen, the fresh or dry block root of Scrophulariaceae herbaceos perennial glutinous rehmannia Rehmannia glutinosaLibosch..Heat-clearing, promote the production of body fluid, moisturize, laxation, the broken stasis of blood, raw new, pain relieving, menstruation regulating, the metal-inflicted wound stasis of blood, cool blood, hemostasis; The effect of fresh rehmannia root and radix rehmanniae recen is different.Fresh rehmannia root clearing heat and promoting fluid, can stop blooding and cool blood, be often for consumption of YIN caused by febrile disease, the illnesss such as haematemesis, abscess of throat, the deep red polydipsia of tongue, a spot dermexanthesis and nosebleed heat.Relative to fresh rehmannia root, radix rehmanniae recen is heat clearing and blood cooling, also can promote the production of body fluid, all right yin-nourishing, is used for treatment yin asthenia generating intrinsic heat, hectic fever due to yin labor heat, the deep red polydipsia of tongue, sends out the problems such as spot dermexanthesis.The dried rhizome of rehmannia is cold in nature, and function is enriching yin and nourishing kidney.Not only promote the production of body fluid to quench thirst and heat clearing and blood cooling, also have effect to metrorrhagia, irregular menstruation, fetal irritability, constipation etc., every blood system has the people of thermal burn the moon, can often take.If want to treat warm heat disease, qingying decoction can be done with the dried rhizome of rehmannia; If the later stage for the treatment of warm disease, because She's heat does not also disappear to the greatest extent, the dried rhizome of rehmannia should be used for boiling Qinghao Biejia Tang; In addition, contain for blood-head poison, macula purple is black, and the serious heat of warm heat disease enters the symptom of ying blood, can take the Sisheng Wan that the dried rhizome of rehmannia is made; General want nourishing Yin and promoting production of body fluid to treat interior heat quenches one's thirst with constipation, the once liquid soup that the dried rhizome of rehmannia boils should be eaten.
Semen Benincasae is sweet, cool." herbal classic ": taste is sweet, flat.Clearing lung and eliminating phlegm; The carbuncle that disappears apocenosis; Dampness removing.Main phlegm-heat cough; Lung carbuncle; Acute appendicitis; Gonorrhoea; Under band; Beriberi; Oedema; Stranguria." Japan hanako materia medica ": peeling skin wind shells black Shao-, profit skin." detailed outline ": control acute appendicitis." Bencao Jingshu ": can whet the appetite the Pi that wakes up.
Selfheal nutrition comparatively horn of plenty, containing compositions such as protein, fat, carbohydrate, carrotene, vitamin B2, niacin and vitamin Cs in young stem and leaf.In addition, also containing saponin, rutin, selfheal glucoside, hyperin and volatilization wet goods.Selfheal is cold in nature, sweet, pungent, the micro-hardship of taste, there is the effect of letting out clearly irascibility, mass dissipating and swelling eliminating, clearing heat and detoxicating, expelling phlegm and arresting coughing, cooling blood and hemostasis, under being applicable to scrofula, goitre, acute mastitis, vertigo, facial paralysis, arthralgia and myalgia, pulmonary tuberculosis, metrorrhagia, band, Fiedeler's disease type hepatitis and bacillary dysentery etc.Modern pharmacological research shows, selfheal has the effect reduced blood pressure, and energy hemangiectasis, contained by it, rutin has antiinflammatory action, and can reduce vasopermeability, reduces fragility, reduces liver fat.Selfheal also has the effect of resisting cancer cell.
Gynostemma pentaphylla finds through modern medicine study, gynostemma pentaphylla principle active component is polysaccharide, flavonoids, saponins and microelement kind, its effect mainly promotes body fat class metabolism, nutrition human body cell, there is good detoxicating, relieving inflammation effect simultaneously, be widely used in high fat of blood, fatty liver, obesity, constipation, insomnia, hepatitis B, the treatment of chronic airway inflammation (sphagitis, enterogastritis etc.) and health care.
Sealwort is used as medicine with rhizome.There is boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney benefiting functions.Be used for the treatment of weakness of the spleen and the stomach, fatigue and asthenia, dry food is few, deficiency syndrome of the lung cough caused by dryness, asthenia of essence and blood, and interior heat such as to be quenched one's thirst the disease.Very effective in cure for diabetes.Stir-baked RHIZOMA POLYGONATI with yellow rice wine is also known as processing sealwort.The person of being used as medicine is dried for clean sealwort steams rear section with the auxiliary material such as wine and black soya bean.Have the merit of channels and collaterals of escaping concurrently.Sealwort has hypotensive, hypoglycemic, reducing blood lipid, atherosclerosis, and delay senility and effect such as antibacterial grade, Siberian solomonseal rhizome polysaccharide has Immunestimulatory effect.For the lung-dryness syndrome due to yin deficiency, the few phlegm of dry cough, and the labor of lung-kidney deficiency is coughed chronic cough etc.For weakness of the spleen and the stomach.Both tonifying spleen-yin, again beneficial temper, obtain dizzy, soreness and weakness of waist and knees for deficiency of kidney essence, poliosis and quenching one's thirst.Sealwort strengthens the bone, beneficial marrow, bleaches and sends out; The cough phlegm be suitable for caused by lack of lung-YIN is few, dry cough without phlegm, the diseases such as hemoptysis.
The root of large-flowered skullcap has heat-clearing and damp-drying drug, and cool blood is antiabortive, detoxicating functions.Cure mainly warm heat disease, the infection of the upper respiratory tract, cough with lung heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, hot eyes, fetal irritability, hypertension, carbuncle swell the diseases such as furuncle sore.The clinical practice of the root of large-flowered skullcap is antibacterial not worse than the coptis, and does not develop immunity to drugs.We are by the strong feature of broad-spectrum antibacterial action, are used in fungal culture miscellaneous bacteria and infect special severe, fine by root of large-flowered skullcap extract effect." Bencao Jingshu ": the root of large-flowered skullcap, its property is respectful clearly, so evil removing: bitter is so eliminating dampness; Cold sensation of the genitalia is so victory warm, therefore main all heat.All hot persons, heat symptoms caused by an exopathgen with all over heat also, jaundice, intestines are out-of-the-way, let out dysentery, and the disease of all damp and hot victory also, analyses it, then all diseases are from recover.Bitter cold can except damp and hot, thus small intestine profit and water from by, source is clearly then flowed also clean.The blood person of closing, real heat is at blood system, and instant heating human blood room, make us obstructed through closing, damp and hot solution, then Ying Qi clearly and voluntarily also.Dislike sore subcutaneous ulcer erosion person, blood-head then stays knot, and is that the carbuncle stain that swells is also rotten: fiery ulcer person, also, cool blood heat extraction, then self-healing also for internal heat blood trouble.The root of large-flowered skullcap has antiallergic action and antiinflammatory action: the anaphylaxis contractile response that baicalin contained by the root of large-flowered skullcap and baicalein can obviously suppress sensitized guinea pig rat small intestine in vitro and isolated tracheal to produce antigen, to passive general allergy and the cavy passivity skin allergic reaction of cavy and mouse, baicalin and baicalein also have inhibitory action.The root of large-flowered skullcap has refrigeration function, and most test proves, the effective ingredient baicalein of the root of large-flowered skullcap has refrigeration function.The root of large-flowered skullcap has detoxication, and baicalin has obvious detoxication, and this may be that baicalin decomposites glucuronic acid due under the effect of glucuronidase, and caused by being combined with multiple poisonous substance.The LD 50 that baicalin 10 milligrams can improve strychnine reaches 2.5 times, and the hepatic glycogen content of carbon tetrachloride poisoning mouse is increased.
Lotus leaf contains multiple alkaloid and vitamin C, the polysaccharide such as nuciferine (Roemerine), miltanthin (Pronuciferine) and Nuciferine (Nuciferine).There is the effect of clearing heat and detoxicating, cool blood, hemostasis.There are the effects such as clearing summer-heat and damp, sending up the lucid yang, cooling blood and hemostasis.Modern study shows, lotus leaf also has effect for reducing blood fat, so a lot of fat-reducing, lipopenicillinase, all contain lotus leaf in product for resolving poxes.Clearing summer-heat and damp, sending up the lucid yang, hemostasis, hypotensive, reducing blood lipid.Be applicable to that the dizzy brain of heatstroke thermic rises, polydipsia uncomfortable in chest, scanty drak urine etc.Lotus leaf look dark green, and gas fragrance is the raw material often selected in traditional herbal cuisine.Recent studies confirms, lotus leaf has the effect of good reducing blood lipid, norcholesterol and fat-reducing, and its dietotherapy scope expands further.
Specific embodiment 1:
First plucked by the Fructus Sophorae, nine steam nine shines, and then adds honey modulation.
Again by all the other raw material lotus leaves, gynostemma pentaphylla, the dried rhizome of rehmannia, selfheal, snakegourd, Semen Benincasae, sealwort, Poria cocos, the bighead atractylodes rhizome, the red sage root, the root bark of white mulberry, the root of large-flowered skullcap, is extracted to concentrate and is made granule, pulvis or paste.
The extract of the Fructus Sophorae be mixed with and other raw materials, ultraviolet radiation for sterilizing and disinfecting packs, and directly can take after mixing it with hot water during use.
Specific embodiment 2:
In midwinter, after the dry Fructus Sophorae being adopted down from Chinese scholar tree, clear water is cleaned, and dries, and removing impurity and dust, be placed on food steamer, add burning hot steaming; Steamed, dry; Such Continuous Heat steams nine times, airing nine times; When the Fructus Sophorae becomes aterrimus, after treating its drying, approximately obtain Fructus Sophorae 5000g, then get honey and put into pot heating, pour in pot by the Fructus Sophorae shone after honey melts, stirring loads container after cooling and dries in the shade, and sealing saves backup.
By surplus stock lotus leaf 1500g, gynostemma pentaphylla 1500g, dried rhizome of rehmannia 1500g, selfheal 1500g, snakegourd 1500g, Semen Benincasae 1500g, sealwort 1500g, Poria cocos 1500g, bighead atractylodes rhizome 1500g, red sage root 1500g, root bark of white mulberry 1500g, root of large-flowered skullcap 1500g, cleans impurity elimination, dries, be ground into particle, soak 1 hour; Soaked bulk drug is put boiling secondary in multi-function extractor; Add up the water of medicinal material 10 times amount for the first time, decoct 1.5 ~ 2 hours, get decocting liquid, filter; Second time adds up the water of medicinal material 7 times amount, decocts 1 ~ 1.2 hour, gets twice decocting liquid mixing, filters; The filtrate of filtration inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Refrigeration liquid is added the filter aid diatomite of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, adds dextrin and make granule.Again the Fructus Sophorae prepared is mixed with the granule made, ultraviolet disinfection, pack and get final product.
Specific embodiment 3:
In midwinter, after the dry Fructus Sophorae being adopted down from Chinese scholar tree, clear water is cleaned, and dries, and removing impurity and dust, be placed on food steamer, add burning hot steaming; Steamed, dry; Such Continuous Heat steams nine times, airing nine times; When the Fructus Sophorae becomes aterrimus, after treating its drying, approximately obtain Fructus Sophorae 4000g, then get honey and put into pot heating, pour in pot by the Fructus Sophorae shone after honey melts, stirring loads container after cooling and dries in the shade, and sealing saves backup; By surplus stock lotus leaf 1200g, gynostemma pentaphylla 1300g, dried rhizome of rehmannia 1100g, selfheal 1200g, snakegourd 1200g, Semen Benincasae 1100g, sealwort 1200g, Poria cocos 1100g, bighead atractylodes rhizome 1200g, red sage root 1200g, root bark of white mulberry 1100g, root of large-flowered skullcap 1200g, put it in 10 times of water gagings and soak.Drop into multi-function extractor and extract twice, first time adds 8-10 times amount soak by water 1-2 hour, and second time adds 4-8 times amount soak by water 1-2 hour, merges twice decocting liquid, filters to get filtrate; Heating is concentrated into powder, then puts into baking oven inner drying powdered, and hybrid packed with the Fructus Sophorae prepared after ultraviolet radiation for sterilizing and disinfecting, during use, direct boiling water is taken after mixing it with water.
Specific embodiment 4:
In midwinter, after the dry Fructus Sophorae being adopted down from Chinese scholar tree, clear water is cleaned, and dries, and removing impurity and dust, be placed on food steamer, add burning hot steaming, steamed, dry, such Continuous Heat steams nine times, airing nine times, when the Fructus Sophorae becomes aterrimus, after treating its drying, approximately obtain Fructus Sophorae 4500g, then get honey and put into pot heating, pour in pot by the Fructus Sophorae shone after honey melts, stirring loads container after cooling and dries in the shade, and sealing saves backup, by surplus stock lotus leaf 1300g, gynostemma pentaphylla 1200g, dried rhizome of rehmannia 1200g, selfheal 1300g, snakegourd 1200g, Semen Benincasae 1300g, sealwort 1200g, Poria cocos 1300g, bighead atractylodes rhizome 1200g, red sage root 1300g, root bark of white mulberry 1200g, root of large-flowered skullcap 1300g, add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating is concentrated into paste, stand for standby use, become component 1, again the dregs of a decoction that alcohol extract is crossed are put into 10 times of water gagings, heating and refluxing extraction 2 times, each extraction time is 1 ~ 2 hour, and 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating be concentrated into paste, stand for standby use, become component 2, merge component 1 and component 2 paste making agent, the Fructus Sophorae that combination system is got ready, pack.
Pharmacological toxicity is tested
Experimental example 1: acute toxicity test of the present invention
One, test material: animal: Kunming mouse, body weight 18-25g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: the present invention's (all raw material mixing decoction 2 times merges and filters, taking liquid) is containing 0.0365mg/ml.
Two, method:
1, LD50 calculates: adopt improvement karber's method, mouse is divided into 5 groups at random, often organize 10, male and female half and half, dissolve adding distil water of the present invention, are made into Cmax, by the administration of mouse maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.
2, maximum tolerated dose measures (MTD value): get mouse 20, each 10 of male and female.Adding distil water of the present invention is dissolved, is made into maximum concentration, by the maximal tolerance dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.
Three, result of the test:
In LD50 calculates when giving mouse with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the state of mind etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.
Experimental example 2: the result of the test of acute toxicity and long term toxicity
Acute toxicity test: give the present invention by the disposable gavage of small white mouse, maximum concentration 35%, maximum gavage capacity 0.4ml/10g, dosage 14g/kg (every g medicinal powder is equivalent to 10g crude drug), Continuous Observation 7 days, do not find any toxic reaction, because concentration and dosage cannot increase, therefore fail to measure the LD50 of this medicine.Maximum tolerance determination: with maximum concentration, maximum gavage capacity, mice lavage administration 3 times, 5 hours, interval, then Continuous Observation 7 days, none example is dead.Medicinal powder dosage is > 42g/kg. day (every g medicinal powder is equivalent to 10g crude drug), calculates 420 times of the clinical consumption per day that is equivalent to be grown up by kg body weight.
Long term toxicity test: whether produce toxic reaction for observing long-term prescription, give rat the present invention respectively and raise clothes, by adult 70 times of clinical consumption per day and 35 times (i.e. 7g/kg/ day and 3.5g/kg/ day), give continuously and feed 8 weeks, have no the behavior of rat, feed, body weight appearance extremely, with control group ratio, routine blood test, hepatic and renal function, the change all without exception of various important organ, within the scope of institute's dosage, do not find any toxicity of the present invention.Confirmed by the acute and chronic toxicity test of animal, safe range of the present invention is comparatively large, is a kind of safe and reliable health products.
Pharmacological experiment:
Observe the present invention to the impact of animal used as test blood pressure and blood lipoid.Method: adopt the diabetic mouse model caused by alloxan, with streptozotocin mycin (STZ) and the method giving high caloric diet copies type ii diabetes rat model, treat respectively with the present invention, Glipizide, then claim its body weight, measure serum triglyceride, cholesterol, serum insulin content and carry out dextrose tolerance test.Result: the present invention obviously reduces the blood sugar of diabetic mice, alleviates the body weight of diabetes B rat, stops fat generation.Also can reduce Peripheral Blood insulin level simultaneously, improve the ubiquitous notable feature of this diabetes B of insulin resistance.Conclusion: the present invention has obvious hypoglycemic lipid-lowering effect.
1 materials and methods
1.1 animals used as test: Wister rat, male, body weight 200 ~ 250g; Every only about the 18 ~ 20g of Kunming mouse (male and female dual-purpose), above animal is Shandong agricultural college animal center and provides.
1.2 high-calorie feed: mixed with sucrose, refining lard by basal feed, its total amount of heat is 20.08KJ/g (protein 15%, carbohydrate 51%, fat 25%).
1.3 medicines and reagent: Fructus Sophorae 30g, lotus leaf 12g, gynostemma pentaphylla 13g, dried rhizome of rehmannia 12g, selfheal 11g, snakegourd 12g, Semen Benincasae 13g, sealwort 12g, Poria cocos 13g, bighead atractylodes rhizome 12g, red sage root 12g, root bark of white mulberry 13g, root of large-flowered skullcap 10g (purchased from Shandong College of Traditional Chinese Medicine's Baokang hospital clinic), make after water decoction-alcohol sedimentation 100% liquid for subsequent use.STZ is Sigma Products, lot number: S0130; Alloxan is Sigma Products, faces the used time is made into 1% solution with citric acid one sodium citrate buffer solution of 0.1mmol/L, pH4.2; Glipizide tablet is Hainan Jin Xiao pharmaceutical Co. Ltd product, lot number: 001213; Blood sugar kit, Cholesterol Kit, Triglyceride Reagent box and serum insulin radioimmunological kit are all purchased from Beijing Zhongsheng Biological Engineering High Technology Company.
1.4 laboratory apparatus: semi-automatic biochemical analyzer: EPPENDORF-F6124 type, Germany; Radioimmunoassay instrument: naval's Medical Devices head factory, China.
The preparation of 1.5 experimental models: the preparation of diabetic hyperlipemia rat model: rat tail vein fast injection STZ30mg/kg, feeds with basal feed, freely drinks water, and tail vein blood after 2 weeks, carries out dextrose tolerance test; Select impaired glucose tolerance rat to feed with Prof. Du Yucang high-calorie feed, continue nursing 2 months.
The preparation of diabetic mouse model: get Kunming mouse, fasting 10h, then tail vein injection alloxan 100mg/kg, gets blood from mouse orbit after 72h, surveys blood glucose value; Blood glucose value is modeling success more than 11.0mmol/L person, for later experiment.
1_6 observation index and method: body weight: weigh with the electronic scale that Sartorius (Germany) produces.Blood sugar: GOD-PAP method.Serum triglyceride: GPO-PAP method.Serum cholesterol: CHO13-PAP method.Above 3 indexs, all by the operation of medicine box description, are produced EPPENDORF-F6124 type semi-automatic biochemical analyzer with Germany and are measured.Serum insulin is with putting the method for exempting from, and by specification operates.
1.7 data processings: experimental data represents with-X ± S, data statistics validity adopts t inspection.
2 experimental results
2.1 the present invention are on the impact of normal mouse blood sugar: get mouse 30, random point 3 groups: normal group, of the present invention group (5g/kg) and Glipizide group (1.3mg/kg).The morning every day gastric infusion, continuous 14d, fasting 6h after last administration, in mouse orbit get blood survey blood sugar.Result shows, the present invention does not have hypoglycemic activity (P > 0.05) to normal mouse.In table 1.
Table 1 the present invention is on the impact of normal mouse blood sugar.(x±s)
| Group | N | Blood sugar mmol/L |
| Normal group | 10 | 6.26±1.34 |
| Of the present invention group | 10 | 5.89±1.15* |
| Glipizide group | 10 | 4.59±0.86** |
Note: compare with normal group, * P > 0.05, * * P < 0.01
2.2 the present invention are on the impact of alloxan diabetes mouse: get normal mouse 10, survey its blood glucose value, feed with conventional feed.Separately get into mould mouse 50, be divided into 5 groups at random, be i.e. model group, of the present invention group (high, medium and low dosage group) and Glipizide group, successive administration 14d.Above 6 groups of mouse orbits are got blood, are surveyed its blood glucose value by 1h after last administration.
Result shows, give with alloxan after, model group compared with normal control group mice blood sugar level significantly raises, and still maintains higher level to experiment 14d its blood sugar.Of the present invention group of blood sugar level is starkly lower than model group, shows that the present invention can make alloxan diabetes mouse blood sugar reduce (P < 0.05), but still higher than Normal group (P < 0.05).In table 2.
Table 2 the present invention is on the impact (x ± s) of alloxan diabetes mouse blood sugar
Note: compare with normal group, * P < 0.05, * * * P < 0.01; Compare with model group, Δ P < 0.05, Δ Δ Δ P < 0.001
2.3 the present invention are to the effect of diabetic hyperlipemia rat
2.3.1 the present invention is on the impact of diabetic hyperlipemia rat body weight: grouping, administration is the same, day administration 1 time, continuous gavage 30 days.Experimental session drinking water for animals and feed without restriction.
Result shows, model group body weight is apparently higher than normal group (P < 0.01), of the present invention group and Glipizide group body weight are starkly lower than model group (P < 0.01, P < 0.05), of the present invention group and Glipizide group compare indifference (P > 0.05, P > 0.05) with normal group.Illustrate that the present invention has the effect of certain reduction rat model body weight.In table 3.
Table 3 the present invention is on the impact (x ± s) of diabetic hyperlipemia rat body weight
| Group | N | Dose | Body weight (g) |
| Normal group | 10 | —— | 246.00±15.84 |
| Model group | 10 | —— | 316.5±18.34** |
| Of the present invention group (low) | 10 | 5g/kg | 285.65±15.31Δ |
| Of the present invention group (in) | 10 | 10g/kg | 280.26±18.34ΔΔ |
| Of the present invention group (height) | 10 | 15g/kg | 270.45±17.43ΔΔ |
| Glipizide group | 10 | 1.3mg/kg | 272.67±19.65Δ |
Note: compare with normal group, * * P < 0.01; Δ P < 0.05 is compared, Δ Δ P < 0.01 with model group
2.3.2 the present invention is on the impact of diabetic hyperlipemia rat glucose tolerance: grouping is the same with administration.Rat Fast 8h, intraperitoneal injection 1.11mol/L glucose solution 2g/kg, docking is got blood and is surveyed (0), 30,60 and 120min blood glucose value at once.Check through t, model group IGT (compares with 120min at once, P < 0.05), Analysis of variance, this group 30,60 and 120min blood sugar are apparently higher than normal group (P < 0.001, P < 0.01 and P < 0.05).Of the present invention group 30 and 60min are significantly higher than normal group (P < 0.001, P < 0.01), but be also starkly lower than model group (P < 0.01, P < 0.05), and normal glucose tolerance (at once comparing with 120min, P > 0.05).In table 4.
Table 4 the present invention is on the impact (x ± s) of diabetic hyperlipemia rat glucose tolerance
Note: compare with normal group, * P < 0.05, * * P < 0.01, * * * P < 0.001; Compare with model group, Δ P < 0.05, Δ Δ P < 0.01; At once compare with this group, ▲ P < 0.05.
2.3.3 the present invention is on the impact of diabetic hyperlipemia rat blood serum triglycerides, cholesterol: grouping, administration is the same.Result shows, the obvious rising of model group serum triglyceride, cholesterol and normal group (P < 0.001, P < 0.001); Two places soup is respectively organized all higher than normal group (P < 0.01, P < 0.001), but is starkly lower than model group (P < 0.001, P < 0.001); Glipizide is all apparently higher than control group (P < 0.001, P < 0.001), but no significant difference (P > 0.05, P > 0.05) is compared with model group.Illustrate that the present invention has certain reduction serum triglyceride, the effect of cholesterol, row pyrazine does not but have this to act on.In table 5.
Table 5 the present invention is on the impact (x ± s) of diabetic hyperlipemia rat blood serum triglycerides, cholesterol
Note: compare with normal group, * P < 0.01, * * P < 0.001; Compare with model group, Δ P < 0.001
2.3.4 the present invention is on the impact of diabetic hyperlipemia rat blood serum insulin: grouping, administration is the same.Result shows, model group serum insulin is apparently higher than normal group (P < 0.01); The present invention respectively organizes and is starkly lower than model group (P < 0.05 with Glipizide group, P < 0.05), but also higher than normal group (P < 0.05, P < 0.05).Illustrate that the present invention has the effect of certain reduction serum insulin, this effect is similar to Glipizide.In table 6.
Table 6 the present invention is on the impact (x ± s) of diabetic hyperlipemia rat blood serum insulin
| Group | N | Dose | Insulin μ IU/ml |
| Normal group | 10 | —— | 22.84±2.42 |
| Model group | 10 | —— | 28.11±2.41** |
| Of the present invention group (low) | 10 | 5g/kg | 24.58±1.32*Δ |
| Of the present invention group (low) | 10 | 10g/kg | 24.41±1.65*Δ |
| Of the present invention group (low) | 10 | 15g/kg | 24.02±1.33*Δ |
| Glipizide group | 10 | 1.3mg/kg | 24.06±1.47*Δ |
Note: compare with normal group, * P < 0.01, * * P < 0.001; Compare with model group, Δ P < 0.005
Experiment shows that the present invention obviously can reduce blood glucose in diabetic mice, but the blood sugar level of intact animal is not affected, its hypoglycemic mechanism has nothing to do with directly stimulating the effect of B cell excreting insulin, the damage of B cell may be alleviated with it, recover the impaired 26S Proteasome Structure and Function of pancreas islet and pass through relevant to glycometabolic adjustment.Also can reduce Peripheral Blood insulin level simultaneously, improve the ubiquitous feature of this diabetes B of insulin resistance.In addition, the present invention can alleviate the body weight of diabetes B rat, presses down the generation that resistance is fat, makes body weight can control, in normal scope, to reduce the hyperlipidemia that diabetes occur together.
Modern Chinese herbal medicine pharmacology has confirmed that the Fructus Sophorae of the present invention, selfheal, the dried rhizome of rehmannia, the root bark of white mulberry have certain hypoglycemic or effect for reducing fat, although the composition of pharmacodynamics of the present invention it be not immediately clear, but hypoglycemic lipid-lowering effect of the present invention can not be ignored, there is good material base.We are certain to the improvement result of the pathogenetic essence-deficiency of Yin of glycosuria, and compare with traditional Chinese medical theory from the cloudy thanks to scorching interpretation of the cause, onset and process of an illness of diabete to nourishing Yin and clearing heat diagnosis and treatment based on an overall analysis of the illness and the patient's condition and conform to, its mechanism of action needs to be furtherd investigate from now on.
In recent years, along with improving constantly of people's living standard, the disease incidence such as diabetes, coronary heart disease increases day by day.Chinese herbal medicine effect is stablized, few side effects, and research has the Chinese herbal medicine of hypoglycemic lipid-lowering effect, can provide more method for clinical treatment diabetes, hyperlipidemia.Fructus Sophorae tea glycol is good to eat, long times of aftertaste, and this tea has softening blood vessel, hypotensive, norcholesterol, dispelling wind heat, profit large intestine, effect of cool blood defaecation.Ambition is unhappy, and hot eyes is shed tears, and dizzy for falling, it is quite helpful that hemorrhoid hemorrhage person often drinks this tea.Especially to falling three fat, prevention and therapy hemorrhoid have fabulous curative effect.Heat-clearing, profit liver, cool blood, hemostasis.Control intestines diarrhea due to wind-evil blood, hemorrhoid blood, uterine bleeding, blood drenches, bloody flux, and ambition is unhappy, and wind is dizzy for falling, and the erosion of vulva is wet itches.Clear away heart-fire, lung, spleen, liver, large intestine fire.Control trusted subordinate's heat pain.Profit liver is nourished blood.Control infantile malnutrition due to digestive disturbances or intestinalparasites, malignant boil, bloody flux, collapse blood; Nucleon in its angle, mends brain, desinsection.
Claims (10)
1. a Fructus Sophorae tea for hypoglycemic, is characterized in that, the parts by weight of the various raw materials of described Fructus Sophorae tea comprise: the Fructus Sophorae 10 ~ 50 parts, 10 ~ 20 parts, lotus leaf, gynostemma pentaphylla 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, selfheal 10 ~ 20 parts, snakegourd 10 ~ 20 parts, Semen Benincasae 10 ~ 20 parts, sealwort 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the bighead atractylodes rhizome 10 ~ 20 parts, the red sage root 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, the root of large-flowered skullcap 10 ~ 20 parts.
2. the Fructus Sophorae tea of hypoglycemic according to claim 1, it is characterized in that, the parts by weight of the various raw materials of described Fructus Sophorae tea comprise: the Fructus Sophorae 10 ~ 30 parts, 10 ~ 15 parts, lotus leaf, gynostemma pentaphylla 10 ~ 15 parts, 10 ~ 15 parts, the dried rhizome of rehmannia, selfheal 10 ~ 15 parts, snakegourd 10 ~ 15 parts, Semen Benincasae 10 ~ 15 parts, sealwort 10 ~ 20 parts, 10 ~ 20 parts, Poria cocos, the bighead atractylodes rhizome 10 ~ 20 parts, the red sage root 10 ~ 20 parts, the root bark of white mulberry 10 ~ 20 parts, the root of large-flowered skullcap 10 ~ 20 parts.
3. the Fructus Sophorae tea of hypoglycemic according to claim 1, it is characterized in that, the parts by weight of the various raw materials of described Fructus Sophorae tea comprise: the Fructus Sophorae 10 ~ 40 parts, 10 ~ 20 parts, lotus leaf, gynostemma pentaphylla 10 ~ 20 parts, 10 ~ 20 parts, the dried rhizome of rehmannia, selfheal 10 ~ 20 parts, snakegourd 10 ~ 20 parts, Semen Benincasae 10 ~ 20 parts, sealwort 10 ~ 15 parts, 10 ~ 15 parts, Poria cocos, the bighead atractylodes rhizome 10 ~ 15 parts, the red sage root 10 ~ 15 parts, the root bark of white mulberry 10 ~ 15 parts, the root of large-flowered skullcap 10 ~ 15 parts.
4. the preparation method of the Fructus Sophorae tea of hypoglycemic as described in any one of claims 1 to 3 item, it is characterized in that, the preparation process of described Fructus Sophorae tea comprises following aspect:
A. the preparation of the Fructus Sophorae;
B. by other raw material soaking ethanol described, extract 2 times;
C. again the concentration of liquid medicine that surplus stock extracts is become granule, pulvis or paste;
D. concentrated granule, pulvis or paste are mixed with the Fructus Sophorae prepared, be prepared into health protection tea.
5. the preparation method of the Fructus Sophorae tea of hypoglycemic according to claim 4, is characterized in that, in described step a, in midwinter, after the dry Fructus Sophorae being adopted down from Chinese scholar tree, clear water is cleaned, and dries, and removes impurity and dust, is placed on food steamer, adds burning hot steaming; Steamed, dry; Such Continuous Heat steams nine times, airing nine times; When the Fructus Sophorae becomes aterrimus, after treating its drying, get honey and put into pot heating, pour in pot by the Fructus Sophorae shone after honey melts, stirring loads container after cooling and dries in the shade, and sealing saves backup.
6. the preparation method of the Fructus Sophorae tea of hypoglycemic according to claim 4, is characterized in that, in described step b, surplus stock is cleaned impurity elimination, dries, be ground into particle, add in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extract, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 pasty state, stand for standby use.
7. the preparation method of the Fructus Sophorae tea of hypoglycemic according to claim 4, it is characterized in that, in described step c, pasty state concentrate is inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrate of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Will refrigeration liquid add 0.3% filter aid diatomite, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 1g crude drug amount, convection drying powdered, or adds dextrin and be in harmonious proportion and make particle.
8. the preparation method of the Fructus Sophorae tea of hypoglycemic according to claim 4, it is characterized in that, in described steps d, the powder prepare the Fructus Sophorae prepared and surplus stock or particle mix, and ultraviolet disinfection is packed and be get final product.
9. a preparation method for basis Fructus Sophorae tea of hypoglycemic as described in any one of claims 1 to 3 item, is characterized in that, when paste made by other raw materials of the Fructus Sophorae tea of described hypoglycemic, step is:
A, get other raw materials and put into ethanol and soak, heat is extracted 2 times, and becoming paste, is component 1;
B, dregs of a decoction extracting in water 3 times, thickening filtration is paste, is component 2;
C, by also 2-in-1 to component 1 and component, be condensed into medicinal extract, after ultraviolet radiation for sterilizing and disinfecting with prepare the Fructus Sophorae and merge and pack.
10. the preparation method of the Fructus Sophorae tea of hypoglycemic according to claim 9, is characterized in that: in described step a, gets raw material and adds in the ethanol of 5-10 times amount and soak 1-2 hour, heating extraction 2 times, each 1-2 hour, removes supernatant, merges extract, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate reduced pressure concentration relative density is 80 DEG C 1.36 medicinal extract, heating be concentrated into paste, stand for standby use, becomes component 1; In described step b, 10 times of water gagings put into by the dregs of a decoction crossed by alcohol extract, and then put into extractor heating and boil 1 hour, filter, filtrate is for subsequent use; Filter residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filter residue adds water again, and half an hour is boiled in third time heating, filters; Three filtrates be combined, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge leaching liquor, are condensed into pasty state, become component 2.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104738250A (en) * | 2015-04-21 | 2015-07-01 | 徐伟明 | Three-high-disease prevention/lowering health tea and preparation method thereof |
| CN104904964A (en) * | 2015-07-07 | 2015-09-16 | 青岛恒波仪器有限公司 | Folium apocyni veneti health tea capable of decreasing sugar and lipid and preparation method thereof |
| CN105194421A (en) * | 2015-11-09 | 2015-12-30 | 青岛安倍康生物医药技术有限公司 | Self-heal health-care oral solution capable of reducing blood fat and preparation method thereof |
| CN105248770A (en) * | 2015-11-09 | 2016-01-20 | 青岛安倍康生物医药技术有限公司 | Danshen root leaf health tea capable of reducing blood fat and preparation method of Danshen root leaf health tea |
| CN113384615A (en) * | 2021-04-21 | 2021-09-14 | 安徽华善堂中药饮片有限公司 | Preparation process of nine-steamed and nine-processed sophora fruit |
| CN114532428A (en) * | 2020-11-18 | 2022-05-27 | 焦新年 | Nine-steaming and nine-sun-drying sophora fruit tea and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1056221A (en) * | 1990-04-28 | 1991-11-20 | 邵文利 | A kind of method for production of Chinese scholartree's pod tea |
| CN1586251A (en) * | 2004-07-08 | 2005-03-02 | 冀瑜 | Multiflower knotweed root composite tea and its preparing method |
| CN103719493A (en) * | 2013-12-31 | 2014-04-16 | 青岛恒波仪器有限公司 | Brain-boosting and intelligence-enhancing sealwort health-care tea and preparation method thereof |
| CN103719495A (en) * | 2013-12-31 | 2014-04-16 | 青岛恒波仪器有限公司 | Great burdock achene healthcare tea for reducing blood glucose and lipid and preparation method thereof |
-
2014
- 2014-11-24 CN CN201410691382.7A patent/CN104365943A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1056221A (en) * | 1990-04-28 | 1991-11-20 | 邵文利 | A kind of method for production of Chinese scholartree's pod tea |
| CN1586251A (en) * | 2004-07-08 | 2005-03-02 | 冀瑜 | Multiflower knotweed root composite tea and its preparing method |
| CN103719493A (en) * | 2013-12-31 | 2014-04-16 | 青岛恒波仪器有限公司 | Brain-boosting and intelligence-enhancing sealwort health-care tea and preparation method thereof |
| CN103719495A (en) * | 2013-12-31 | 2014-04-16 | 青岛恒波仪器有限公司 | Great burdock achene healthcare tea for reducing blood glucose and lipid and preparation method thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104738250A (en) * | 2015-04-21 | 2015-07-01 | 徐伟明 | Three-high-disease prevention/lowering health tea and preparation method thereof |
| CN104904964A (en) * | 2015-07-07 | 2015-09-16 | 青岛恒波仪器有限公司 | Folium apocyni veneti health tea capable of decreasing sugar and lipid and preparation method thereof |
| CN105194421A (en) * | 2015-11-09 | 2015-12-30 | 青岛安倍康生物医药技术有限公司 | Self-heal health-care oral solution capable of reducing blood fat and preparation method thereof |
| CN105248770A (en) * | 2015-11-09 | 2016-01-20 | 青岛安倍康生物医药技术有限公司 | Danshen root leaf health tea capable of reducing blood fat and preparation method of Danshen root leaf health tea |
| CN114532428A (en) * | 2020-11-18 | 2022-05-27 | 焦新年 | Nine-steaming and nine-sun-drying sophora fruit tea and preparation method thereof |
| CN113384615A (en) * | 2021-04-21 | 2021-09-14 | 安徽华善堂中药饮片有限公司 | Preparation process of nine-steamed and nine-processed sophora fruit |
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Application publication date: 20150225 |