CN105194421A - Self-heal health-care oral solution capable of reducing blood fat and preparation method thereof - Google Patents
Self-heal health-care oral solution capable of reducing blood fat and preparation method thereof Download PDFInfo
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Abstract
The invention provides a self-heal health-care oral solution capable of reducing blood fat, which comprises the following raw medicines in parts by weight: 10-50 parts of self-heal, 10-20 parts of cape jasmine, 10-20 parts of pollen typhae, 10-20 parts of purslane, 10-20 parts of rehmannia root, 10-20 parts of baikal skullcap root, 10-20 parts of kudzu root, 10-20 parts of gynostemma pentaphylla, 10-20 parts of sophora fruit, 10-20 parts of dried orange peel, 10-20 parts of corn silk, 10-20 parts of oriental wormwood, 10-20 parts of hawthorn, 10-20 parts of trichosanthes root, 10-20 parts of burdock fruit, 10-20 parts of lysimachia, 10-20 parts of tribulus terrestris, 10-20 parts of oldenlandia and 10-20 parts of centella. The oral solution provided by the invention is capable of preventing absorption of cholic acid or cholesterol from the intestinal tract, promoting cholic acid or cholesterol to be discharged with feces, inhibiting in vivo synthesis of cholesterol, or promoting conversion of cholesterol, promoting LDL receptor expression on a cell membrane, and accelerating lipoprotein decomposition.
Description
Technical field
The present invention relates to the blood fat reducing health products containing deriving from plant composition, particularly a kind of Spica Prunellae antilipemic healthy oral liquid and preparation method thereof.
Background technology
Blood fat is the general name of various lipid material in blood.Wherein the most important thing is cholesterol and triglyceride.Triglyceride i.e. fat.They are water insoluble, become lipoprotein with protein bound, in blood cycle operation.No matter be that cholesterol level increases, or the content of triglyceride increases, or both all increase, and are referred to as hyperlipemia.Investigation display, hyperlipidemia has become the commonly encountered diseases of middle-aged and elderly people, and the various cardiovascular and cerebrovascular disease caused thus have become the main chief culprit threatening middle-aged and elderly people life.
The medicine of plasma triglyceride or reduction plasma cholesterol can be reduced.Hypolipidemic kind is more, classifies also more difficult.With regard to its main hypolipemic function can be divided into fall T-CHOL, mainly fall T-CHOL hold concurrently triglyceride reducing, triglyceride reducing, main triglyceride reducing is double falls the large class of T-CHOL four.It can stop cholic acid or cholesterol from intestinal absorption in summary, promotes that cholic acid or cholesterol are discharged with feces.Suppress to synthesize in the body of cholesterol, or promote that the conversion of cholesterol promotes ldl receptor expression on cell membrane, accelerate lipoprotein and decompose.Activate lipoprotein metabolism enzyme, promote the hydrolysis of triglyceride.Stop in the body of other lipids and synthesize, or promote the metabolism of other lipids.
If the indexs such as your blood fat inspection report shows cholesterol, triglyceride, low density lipoprotein, LDL, apolipoprotein day raise, and high density lipoprotein, the reductions such as ApoA, then point out you to have the susceptible factor of arteriosclerosis and coronary heart disease.At this moment you should note the blood lipid level regulating you.
First hyperlipidemia patient should be taked to keep on a diet, increase motion, the general measure such as lose weight.If invalid, just consider Drug therapy.Hyperlipidemia patient is cautious use of vitamin E.
Reasonable selection lipid-regulation medicine.1. phenoxy acetic acid class, as clofibrate, lipanthyl (fenofibrate), gemfibrozil (clean fat, gemfibrozil), bezafibrate (bezalip) etc., be a most widely used class medicine at present, it can reduce low-density lipoprotein cholesterol and triglyceride, then has rising effect to HDL-C.2. methylol penta diether coenzyme A reductase enzyme preparation (his class D), as lovastatin, Teroltrat, Xuezhikang (zhibituo), simvastatin (simvastatin), general Liprevil (Provastain) etc.More obvious than phenoxy acetic acid class to the reducing effect of low-density lipoprotein cholesterol, the effect of sweet Shan three ester and high density lipoprotein increasing cholesterol of falling is then not as phenoxy acetic acid class.3. polyunsaturated fatty acid, as fish oil preparation (arteries and veins Dong Kang, Max EPA etc.), linolenic acid etc., can reduce triglyceride, but cholesterol reducing effect is poor.4. nicotinic acid class, as flat in nicotinic acid, inositol niacinate, eastern fat, niceritrol etc.But some patients with after have blush, cardiopalmus, skin deadlock are itched, gastrointestinal upset etc.5. Elastase, adjust fat ability more weak, but side effect is little, can be used for slight patient.5. C receptor blocking agent such as spy draws a mile throat, can high density lipoprotein increasing, but easily postural hypotension occurs.Chinese medicine Radix Ginseng, Herb Gynostemmae Pentaphylli, Fructus Crataegi etc. also have certain effect for reducing fat.
The application of principle of lipid lowering agent
(3) many fat regulation medicines, especially affect cholesterol and the bile acid lipid lowerers through bile and defecate, bile cholesterol can be made to be saturated or hypersaturated state, and be easy to form cholelithiasis.
(4) pravastatin has certain infringement to liver.In addition, long-term taking lipid regulating agent can cause body lipid to change, thus causes the generation of non-cardiovascular disease.So once there is untoward reaction, timely drug withdrawal.
(5) because human body needs a certain amount of Lipid to maintain normal body function, so the indexs such as cholesterol, triglyceride, apolipoprotein are too lower than also belonging to abnormal performance normal range.
(6) should give up smoking and give up alcohol.Because smoking can accelerate arteriosclerotic development, one of mechanism is exactly that smoking can reduce plasma hdl level and be unfavorable for the removing to cholesterol, and drinks and can increase the weight of hyperlipemia.
Spica Prunellae is the dry fruit ear of labiate Spica Prunellae PrunellavulgarisL..All parts of the country are all produced, main product in Jiangsu, Zhejiang, Anhui, the ground such as Henan.Gather when summer, fruit ear was brownish red, removing impurity, dries.Raw use.Its property is pungent, bitter, cold.Return liver, gallbladder meridian.There is clearing away heat-fire, improving eyesight, effect of mass dissipating and swelling eliminating.
Treatment conjunctival congestion and swelling pain, dizzy, order pearl nyctalgia of having a headache.Spica Prunellae bitter cold master enters Liver Channel, and kind removing fire from the liver is with improving eyesight.With controlling flaming up of liver-fire, conjunctival congestion and swelling pain, it is medicinal to join Folium Mori, Flos Chrysanthemi, Semen Cassiae etc.Among this product liver heat removing and eyesight improving, nourishing the liver of slightly holding concurrently, joins Radix Angelicae Sinensis, Fructus Lycii, can be used for deficiecny of liver-YIN, ophthalmalgia, to night more particularly; Also can accessory stick up, Radix Glycyrrhizae use, as loose in Spica Prunellae (" Zhang Shi doctor is logical ").
Treatment scrofula, goiter.This product acrid in the mouth energy eliminating stagnation, bitter cold can expel the heat-evil, and it is medicinal to control pathogenic fire derived from stagnation of liver-QI often to join Bulbus Fritillariae Uninbracteatae, Fructus Forsythiae etc., and the scrofula of phlegm-fire cohesion, as Spica Prunellae soup (" Waike Zhengzong, Orthodox Manual of External Diseases "); With controlling goiter, then often join the use such as Thallus Laminariae (Thallus Eckloniae), Radix Scrophulariae, as Spica Prunellae cream (Golden Mirror of Medicine).
Treatment acute mastitis swells and ache.This product heat clearing away can go liver-fire, again can mass dissipating and swelling eliminating, can control acute mastitis and swell and ache, normal with Herba Taraxaci with (" book on Chinese herbal medicine converges and says ").If join Flos Lonicerae, pathopyretic ulcer can be controlled, as detoxicating pill (" blue or green capsule is secretly handed down ").
Shennong's Herbal carries it: " main cold and heat, scrofula, scrofula, head sore, broken disease.Loose wart stagnation of QI, swelling of the feet arthralgia chiefly caused by damp pathogen." Compendium of Material Medica carries it: " Spica Prunellae controls ophthalmalgia, and with Saccharum Sinensis Roxb. water logging one ight, get it and can separate interior-heat, slow liver-fire is also.Lou Quan is apt to cloud, Spica Prunellae control order pearl pain to night then notably, the magical effect, or with bitter cold snack made with traditional Chinese medicines instead notably, the also magical effect.Lid order pearl connects order originally, and liver system also, belongs to the warp of the moon of fainting.Night very and some bitter and cold medicines anti-notably, night is with cold also cloudy therefore also.The gas of the pure sun of summer withered official report, mends cloudy blood vessels of fainting, therefore controls this as god, with Yang Zhiyin also." " notes of Chongqing hall " sub " grass, micro-pungent and sweet, therefore among eliminating stagnation, have the merit with positive yin nourishing concurrently, namely what after losing blood, the person of being insomnia took sleeps, and its property is visible.Chen Jiuzhe is especially sweet, is used as medicine for victory.”
Pharmacological research
1. chemical composition: this product is containing organic acid such as the glycoside materials such as triterpene saponin, rutin, hyperin and ursolic acid, caffeic acid, free oleanolic acids; Containing the anthocyanin, d-Camphora, d-fenchone etc. of delphinidin, cyanidin in spica.
2. pharmacological action: this product decoct, water-leach liquor, alcohol-water leachate and alcohol leaching liquid all can obviously reduce laboratory animal blood pressure, and stem, leaf, fringe and herb all have hypotensive effect, but the effect of fringe is more obvious; This product water decoction-alcohol sedimentation liquid mouse peritoneal is injected, and has obvious antiinflammatory action; This product decoct all has certain inhibitory action to dysentery bacterium, Bacillus typhi, vibrio cholera, escherichia coli, Bacillus proteus, staphylococcus and Bacillus tuberculosis in vitro.
3. clinical research: combine and be used for the treatment of headache, dizzy traditionally, pharmacological research has hypotensive activity, and modern clinic, in order to Hypertension, helps blood pressure lowering; Get its mass dissipating and swelling eliminating and conventional control the person that belongs to liver-heat such as thyromegaly, lymphadenectasis, cyclomastopathy, hypertension; With Spica Prunellae, Herba Hedyotidis Diffusae, Rhizoma Imperatae, Radix Glycyrrhizae, Radix Isatidis, Radix Sophorae Tonkinensis, be decocted in water for oral dose, Treatment chronic Hepatitis B 50 example, cures 33 examples, and take a turn for the better 12 examples; With Spica Prunellae, Pseudobulbus Bletillae (Rhizoma Bletillae), grind to the powder altogether, Adeps Sus domestica adjusts cream to apply affected part, controls rhagadia manus et pedis 36 example, recovery from illness 34 example; Use Spica Prunellae 100g, decocting 2 times, foam washing both hands, treatment hand desquamation demonstrate,proves over one hundred example, all fully recovers.
Spica Prunellae compatibility Radix Angelicae Sinensis, Radix Paeoniae Alba Spica Prunellae liver heat removing scattered silt; Radix Angelicae Sinensis, the Radix Paeoniae Alba nourish blood and enrich blood. and three's compatibility separates stagnation of liver-QI with having, effect of nourishing the liver blood is used for the treatment of all diseases caused by hepatic depression and blood deficiency.
Spica Prunellae compatibility Flos Chrysanthemi Spica Prunellae clearing away liver-fire, suppressing the hyperactive liver sun; The cool liver of Flos Chrysanthemi heat clearing away. Papillary have liver heat removing, cool liver, suppressing the hyperactive liver merit is used for the treatment of flaming up of liver-fire, wind-heat of liver channel causes conjunctival congestion and swelling pain; Or the headache, dizzy that excessive rising of liver-YANG causes.
Spica Prunellae compatibility Thallus Laminariae (Thallus Eckloniae), Sargassum Spica Prunellae clearing away liver-fire Disperse hepatic depression; Thallus Laminariae (Thallus Eckloniae), the equal eliminating phlegm and softening indurated mass of Sargassum and diuretic.Three medicines have share eliminating stagnation of relieving inflammation or internal heat, effect of eliminating phlegm and softening indurated mass is used for the treatment of the caused scrofula of liver-fire expectorant knot.
Spica Prunellae compatibility Radix Scrophulariae, Fructus Forsythiae Spica Prunellae clearing away liver-fire and Disperse hepatic depression; Radix Scrophulariae quench eliminating stagnation; Fructus Forsythiae detoxicating and resolving stagnation of pathogens. three is with strengthening the scrofula being used for the treatment of phlegm-fire and tying mutually by the power of its eliminating stagnation of relieving inflammation or internal heat.
Present various blood fat reducing health products, medicine spreads unchecked, but great majority are had a good apperance only, false propaganda on a grand scale, probably without any health care, but causes the huge injury of the person, therefore, search of health effective blood fat reducing method has very real significance.Hypolipidemic activity material is the key that people expect to solve problem of obesity always safely and effectively.Reducing Blood Lipid by Chinese medicine, having advantage that is nontoxic, that can be absorbed completely by organism, is the Main way that we study.There are blood fat reducing, antibacterial, blood sugar lowering, antioxidation in present market in the urgent need to developing one, and energy interference body is to the absorption of fat, promotes the blood fat-reducing product that the fat taken in excretes, and has health product that are nontoxic, that can be absorbed completely by organism.
Summary of the invention
Technical problem to be solved by this invention is, dragons and fishes jumbled together for most of blood fat-reducing products in present market, false propaganda, probably without any the health care of blood fat reducing, cause the huge injury of the person, therefore, search of health effective blood fat reducing method has very real significance.The present invention retains the effective ingredient of Spica Prunellae, and mouthfeel is aromatic, adds some blood circulation promoting and blood stasis dispelling, fat and serum triglycerides are all had to the Chinese crude drug of obvious reducing effect, and can improve microcirculation, the most mouthfeel of these medical materials is light, make people be easy to accept, more can reach effect of blood fat reducing preferably.
For solving above-mentioned technical barrier, the invention provides a kind of Spica Prunellae antilipemic healthy oral liquid, described in it, Spica Prunellae antilipemic healthy oral liquid comprises the crude drug of following weight portion: Spica Prunellae 10 ~ 50 parts, Fructus Gardeniae 10 ~ 20 parts, Pollen Typhae 10 ~ 20 parts, Herba Portulacae 10 ~ 20 parts, 10 ~ 20 parts, the Radix Rehmanniae, Radix Scutellariae 10 ~ 20 parts, Radix Puerariae 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, the Fructus Sophorae 10 ~ 20 parts, Pericarpium Citri Reticulatae 10 ~ 20 parts, Stigma Maydis 10 ~ 20 parts, Herba Artemisiae Scopariae 10 ~ 20 parts, Fructus Crataegi 10 ~ 20 parts, Radix Trichosanthis 10 ~ 20 parts, Fructus Arctii 10 ~ 20 parts, Herba Lysimachiae 10 ~ 20 parts, Fructus Tribuli 10 ~ 20 parts, Herba Hedyotidis Diffusae 10 ~ 20 parts, Herba Centellae 10 ~ 20 parts.
Described Spica Prunellae antilipemic healthy oral liquid, the crude drug of following weight portion can be comprised: Spica Prunellae 10 ~ 30 parts in Spica Prunellae antilipemic healthy oral liquid described in it, Fructus Gardeniae 10 ~ 15 parts, Pollen Typhae 10 ~ 15 parts, Herba Portulacae 10 ~ 15 parts, 10 ~ 15 parts, the Radix Rehmanniae, Radix Scutellariae 10 ~ 15 parts, Radix Puerariae 10 ~ 15 parts, Herb Gynostemmae Pentaphylli 10 ~ 15 parts, the Fructus Sophorae 10 ~ 15 parts, Pericarpium Citri Reticulatae 10 ~ 15 parts, Stigma Maydis 10 ~ 20 parts, Herba Artemisiae Scopariae 10 ~ 20 parts, Fructus Crataegi 10 ~ 20 parts, Radix Trichosanthis 10 ~ 20 parts, Fructus Arctii 10 ~ 20 parts, Herba Lysimachiae 10 ~ 20 parts, Fructus Tribuli 10 ~ 20 parts, Herba Hedyotidis Diffusae 10 ~ 20 parts, Herba Centellae 10 ~ 20 parts.
Described Spica Prunellae antilipemic healthy oral liquid, the crude drug of following weight portion can also be comprised: Spica Prunellae 10 ~ 50 parts in Spica Prunellae antilipemic healthy oral liquid described in it, Fructus Gardeniae 10 ~ 20 parts, Pollen Typhae 10 ~ 20 parts, Herba Portulacae 10 ~ 20 parts, 10 ~ 20 parts, the Radix Rehmanniae, Radix Scutellariae 10 ~ 20 parts, Radix Puerariae 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, the Fructus Sophorae 10 ~ 20 parts, Pericarpium Citri Reticulatae 10 ~ 20 parts, Stigma Maydis 10 ~ 15 parts, Herba Artemisiae Scopariae 10 ~ 15 parts, Fructus Crataegi 10 ~ 15 parts, Radix Trichosanthis 10 ~ 15 parts, Fructus Arctii 10 ~ 15 parts, Herba Lysimachiae 10 ~ 15 parts, Fructus Tribuli 10 ~ 15 parts, Herba Hedyotidis Diffusae 10 ~ 15 parts, Herba Centellae 10 ~ 15 parts.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Spica Prunellae antilipemic healthy oral liquid, and described in it, the preparation process of oral liquid comprises:
A. gather when Spica Prunellae fruit ear is brownish red when summer, removing impurity, dries, raw use;
B. the Spica Prunellae dried is pulverized, soaked ethanol heating extraction;
C. by other raw material pulverizing described, immersion ethanol extraction;
D. mixed by other raw material extracting solution concentrated with the Spica Prunellae extracting solution prepared, sterilizing is prepared into oral solutions.
In described step a, can between the 6-8 month, when Spica Prunellae fruit ear is brownish red, harvesting, dry in the sun, allow it parch, for subsequent use.
In described step b, Spica Prunellae chopping can be placed in 70-90% ethanol and soak 1-2 hour, in water-bath, be heated to 60 DEG C-70 DEG C, lixiviate 2h, every 10min stirs once, by filtered through gauze, adds 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, every 10min stirs once, filtered through gauze, merges lixiviating solution, be condensed into pasty state filtrate, stand-by.
In described step c, all the other raw materials can be cleaned roguing, put into 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.05 filtrate.
In described steps d, can insert in concentrating under reduced pressure tank by two kinds of extracting solution, decompression recycling ethanol, being concentrated into liquor strength is 0.1g crude drug/mL, when sucking filtration to the relative density of filtrate is 20 DEG C 1.06; Above-mentioned filtrate, after the macroporous adsorptive resins absorption that volume is 10L, with deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, mediation Mel, bottles after ultraviolet ray sterilization bactericidal.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Spica Prunellae antilipemic healthy oral liquid, and the preparation process of described Spica Prunellae oral liquid comprises following aspect:
A. gather when Spica Prunellae fruit ear is brownish red when summer, removing impurity, dries, raw use;
B. the Spica Prunellae dried pulverizing, immersion ethanol are added extraction heat;
C. by other raw material pulverizing described, immersion ethanol extraction;
D. mixed by other raw material extracting solution concentrated with the Spica Prunellae extracting solution prepared, sterilizing is prepared into oral solutions.
In described step b, the extraction step of Spica Prunellae can also be: get Spica Prunellae chopping for subsequent use, steep in the ethanol of 5-10 times amount, be equipped with by medicated powder in lid stainless steel cask, add 70% ethanol, quality is 0.8-1 times of coarse powder, stir, moistening airtight placement more than 1 hour, makes abundant expansion; Drug sample after moistening expansion is mixed pine by filter plate gauze bag parcel again bottom percolator after paving does loose, then powder is contained with rustless steel spoon, uniform loading percolator, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitable pressurization, medicated powder must not load 2/3 eminence exceeding percolator; Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, then slowly add 70% ethanol; Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed and be generally 1000g medical material outflow 2 ~ 3ml per minute, filtrate puts into liquid container, and pours ethanol time emptying into liquid container; Percolate is merged and leaves standstill.
The present invention can stop cholic acid or cholesterol from intestinal absorption, promotes that cholic acid or cholesterol are discharged with feces.Suppress to synthesize in the body of cholesterol, or promote that the conversion of cholesterol promotes ldl receptor expression on cell membrane, accelerate lipoprotein and decompose.Activate lipoprotein metabolism enzyme, promote the hydrolysis of triglyceride.Stop in the body of other lipids and synthesize, promote the metabolism of other lipids.The present invention retains the effective ingredient of Spica Prunellae, and millet paste is aromatic, adds some blood circulation promoting and blood stasis dispelling, fat and serum triglycerides are all had to the Chinese crude drug of obvious reducing effect, and can improve microcirculation, the most mouthfeel of these medical materials is light, make people be easy to accept, more can reach effect of blood fat reducing preferably.
Detailed description of the invention
The triterpene saponin that it is aglycon that Spica Prunellae herb contains with oleanolic acid (Oleanolicacid).Still containing the glycoside material such as rutin (Rutin), hyperin (Hyperoside). also containing organic acid such as ursolic acid (Ursolicacid), caffeic acid (Caffeicacid) and free oleanolic acids. still containing inorganic salts such as vitamin B1, vitamin C, vitamin K, carotene, resin, amaroid, tannin, volatile oil, alkaloid and potassium chloride.
The anthocyanin of delphinidin (Delphinidin) and cyanidin (Cyanidin) is contained in spica, d-Camphora (d-Camphor), d-fenchone (d-Fenchone), ursolic acid, fruit ear is containing ursolic acid (ursolicacid), oleanolic acid (oleanolicacid), ursolic acid and oleanolic acid are the Saponin of main glycoside unit, daucosterol (daucosterol), β-Amyrin (β-mayrin) and its lignoceric acid (tetra-cosanicacid), 20 produce alkanoic acid (hexacosanicacid), the ester of octocosoic acid (octa-cosanicacid) and melissic acid (triacontanicacid).
Herb is containing acidity many grain Polysaccharides from Prunella vulgaris L (prunellin) of tool anti human immune deficiency virus (HIV), also containing oleanolic acid, ursolic acid, oleanolic acid is the Saponin of glycoside unit, globulariacitrin (rutin), hyperin (hyperoside), caffeic acid (caffeicacid), vitamin (vitamins) C, D, D carotene (carotene), tannin (tan-nin), and thing sense (alkaloids) and volatile oil, wherein containing levo-camphor (camphor), dextrorotation fenchone (fenchone).
Modern study
To the effect of cardiovascular system
Spica Prunellae decoct (concentration is 1: 10 ten thousand ~ 1: 100 ten thousand) can make Cor Leporis in place and isolated frog heart shrinkage amplitude increase, but concentration increase (1: 20 ~ 1: 50) then makes shrinkage amplitude diminish.
The water-leach liquor of Spica Prunellae, ethanol water-leach liquor and 30% ethanol extraction, to anesthetized animal lumbar injection, intravenous injection or the oral effect that all reduces blood pressure, intravenous injection hypotensive effect is obvious, oral administration then hypotensive effect is faint. and decoct (100mg/kg) is injected in anesthetized dog, significantly lasting hypotensive effect can be produced, but there is tachylaxis, after vagotomy, its hypotensive effect obviously weakens. to renal hypertension dog, after taking medicine continuously 2 weeks, blood pressure has moderate reduction, returns to again originally level after drug withdrawal.Spica Prunellae stem, leaf, fringe and herb all have hypotensive effect, and the effect of fringe is more weak.
Resisting pathogenic microbes effect experiment in vitro shows: Spica Prunellae decoct all has certain inhibitory action to dysentery bacterium, Bacillus typhi, vibrio cholera, escherichia coli, Bacillus proteus, bacillus pyocyaneus and staphylococcus, streptococcus and Bacillus tuberculosis.
Spica Prunellae can make the pulmonary lesion of the sick mice of experimental M alleviate to some extent.Spica Prunellae fresh goods is squeezed the juice and is all had inhibitory action to staphylococcus aureus, beta hemolytic streptococcus, escherichia coli, Bacillus typhi, dysentery bacterium, diphtheria corynebacterium, anthrax bacillus, bacillus pyocyaneus.
Water logging agent (1: 4) is also had inhibitory action in various degree to permitting some common pathogenic dermatophytes such as blue achorion, Du's big belly microspore achorion difficult to understand in vitro.
Immunosuppressive action
Experiment shows: Spica Prunellae injection 6g (crude drug)/kg subcutaneous injection, can make Cavia porcellus, mice adrenal gland obviously increases, the obvious atrophy of thymus, spleen.Spica Prunellae water decoction-alcohol sedimentation liquid (1: 1) intramuscular injection 3g (crude drug)/kg, can make adult rat adrenal tissue weight increase, and Thymus and spleen weight saving, the wherein remarkable atrophy of thymus, compared with matched group, on average alleviates 63.4%.In addition, the organizational structure of adrenal cortex, thymus and spleen still can be made to change to some extent.
Spica Prunellae decoct (1: 50 ~ 1: 200) can make rabbit isolated uterine occur tetanic contraction.To isolated rabbit intestinal, high concentration can strengthen it and wriggle, and the most responsive with duodenum, ileum sensitivity is poor.Once had report, 100% Spica Prunellae decoct can suppress the growth of mice S180 and ehrlich carcinoma, but the anti-more not administration group of mortality rate is higher.
Spica Prunellae water decoction-alcohol sedimentation liquid all has inhibitory action to mouse knoting oil ear swelling and the swelling of rat yeast toes.
Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, temperature.Return spleen, stomach warp.Cure mainly invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.The Rhizoma Atractylodis Macrocephalae has cytotoxicity to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of body antitumor reaction.Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to mice ehrlich carcinoma, lymphosarcoma ascitic type, the esophageal carcinoma (Ecal09), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Also remarkable inhibitory action is had." property of medicine opinion " carries it: monarch, and sweet in the mouth is pungent, nontoxic.Energy main large migratory arthralgia, for many years diarrhea due to disorder of qi, trusted subordinate's distending pain, the broken dyspepsia that disappears, appetizing, removes sputum, except cold and heat, lets out only.Interarea light is pleased, and preserves youthful looks, de-black.Swelling of harnessing the river is full, tells vomiting, cold type of pain in abdomen, vomits and diarrhoea incessantly, and insufficiency of stomach-QI cold-dysentery.
Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, in tune, dampness, reduces phlegm.Cure mainly distension and fullness in the abdomen or pain, the dyspepsia of stagnation of QI in spleen and stomach.Abdominal distention uncomfortable in chest in turbid damp resistance, indigestion and loss of appetite loose stool.Phlegm-damp stops up the cough and asthma of lung.Therefore Pericarpium Citri Reticulatae has three major types effect, one is lead cold-evil in the heart, two broken stagnant gas, three strengthening the spleen stomaches.This three large on, Main Function is row QI of the spleen and stomach.The main transmitting and distributing the fluids of taste, therefore QI of the spleen and stomach is capable, can dry, spleen invigorating, reduce phlegm, therefore can say again, Pericarpium Citri Reticulatae temperature can support spleen, pungently can be amusing, bitter can spleen invigorating.Due to the main row QI of the spleen and stomach of Pericarpium Citri Reticulatae, taste are located in middle Jiao, and the gas of middle Jiao passes through, and the gas of three Jiao is also sprung up thereupon.Three Jiao are the organ in charge of water circulation, and current water liquid, accompanies with wetting phase; Again for hiding mansion outside mansion, upper and the heart, lung, lower and liver, kidney.So the effect of Pericarpium Citri Reticulatae can wide and all Zang Fu, wet throughout whole body.Say from lung, then pungent loose lung qi, hardship lets out lung qi, temperatureization cold, can control abundant expectoration cough with asthma, and gas is stopped up food and stopped; Say from the heart, then pungent happy gas, hardship lets out heart-fire, and warm removing dampness is turbid, can control irritable feverish sensation in the chest, and the implication sound of vomiting is smelly; Say from liver, then pungent loose stagnation of liver-QI, liver-fire falls in hardship, warming for eliminaring cold-damp, so its can treating the liver be strongly fragrant heat, drink is stopped eating stagnant; Say from kidney, then pungent profit kidney is dry, and hardship is let out kidney and wet, gentle kidney qi, so it can control life fire deficiency, and indigestion.Certainly, all explanations are all relevant with spleen with wet, so its property of medicine effect performance leeway is larger, all can use in general activating QI to eliminate phlegm side.As Li Shizhen (1518-1593 A.D.) is said: " Pericarpium Citri tangerinae hardship can be let out can be dry, pungent energy loose can and, it controls all kinds of diseases and ailments, always gets the merit of its dampness of regulating the flow of vital energy.Then mending with tonic, then rush down with cathartic, then rise with Hydrargyri Oxydum Rubrum, then falling with falling medicine." as with the Rhizoma Atractylodis Macrocephalae with using; then having the effect of tonifying the spleen and stomach; with Radix Ginseng, Radix Glycyrrhizae with the effect then having tonifying the lung gas; with Semen Armeniacae Amarum with then there being logical effect of falling large intestine constipation due to disorder of QI, logical moisten the secret effect of large intestine blood with Semen Persicae with then having, with the Rhizoma Pinelliae with the effect then having dampness; with Poria with the effect then having damp eliminating; with Pericarpium Citri Reticulatae with the effect then having sending down the abnormal ascending QI preventing or arresting vomiting, with Rhizoma Zingiberis with can warming for resolving cold-phlegm, drink with Rhizoma Coptidis is same treat gastrointestinal disease better efficacy with heat-phlegm can be removed or directly take gastrointestinal.
The Radix Rehmanniae is also Radix Rehmanniae, and the fresh or dry tuber of Scrophulariaceae herbaceos perennial Radix Rehmanniae RehmanniaglutinosaLibosch., is used as medicine.Main product is in China Henan, Hebei, the Inner Mongol and northeast.Most area has cultivation.Autumn excavates, using fresh herb or dry sliced raw use.To be Radix Rehmanniae mix steam to inside and outside darkish complexion, glossy through adding yellow wine Radix Rehmanniae Preparata, or directly steam to black profit and form.Cut sheet to use.Effect that Radix Rehmanniae has clearing away heat and cooling blood, tonifying YIN promotes the production of body fluid.The evaluation of Li Shizhen (1518-1593 A.D.) to Radix Rehmanniae is: " one hundred days of clothes are rosy cheeks, within 3 years, make light of one's life by commiting suicide not old.”
The Fructus Sophorae: bitter, cold.Return liver, large intestine channel.Function with cure mainly: clearing away heat-fire, cooling blood for hemostasis.Have blood in stool for intestinal heat, hemorrhoid swell hemorrhage, and liver-heat is had a headache, dizzy conjunctival congestion.The Flos Sophorae Immaturus, the Fructus Sophorae in medical, not only for traditional Chinese medical science formula, and are the important source material of Chinese medicine industry and medical industry.According to statistics, kind more than 30 is reached with the Flos Sophorae Immaturus, the Fructus Sophorae chiang ya wan that is raw material production, JINGWANHONG, Pilulae Fructus Sophorae; The seventies, along with the development of medical industry, produce rutin, beniol, troxerutin etc., to diseases such as treatment coronary heart disease, hypertension, cerebral vessels embolisms, evident in efficacy.For Pharmacopoeia of the People's Republic of China nineteen ninety version is recorded.Flower is claimed Flos Sophorae by medical material commodity, and alabastrum claims the Flos Sophorae Immaturus, and fruit claims the Fructus Sophorae.In " herbal classic " main five, pathogen heat, only saliva and spittle, mend and hinder absolutely, five hemorrhoid, burn, and married woman's breast abdominal mass, son hides shoot.Supplement to the Herbal parasite killing removes wind, and improving eyesight is except hot tears, and between brains ambition, hot blast is unhappy, and dizziness due to wind pathogen is for falling, and salivation is as liquor-saturated in mind, ripples as person on ship car.
Rhizoma Alismatis: be longer than promoting diuresis to eliminate damp pathogen, expels the heat-evil, for dysuria, and edema distension, the puckery pain of stranguria with turbid discharge, seminal emission, foot knee joint flaccidity is soft; Fry Rhizoma Alismatis, be partial to and spleen eliminating dampness by diuresis, for phlegm retention, dysentery, the vertigo.Rhizoma Alismatis, Poria, Polyporus; Three all can seep water dampness removing and inducing diuresis to remove edema, and Chang Sanzhe is with using; Right Rhizoma Alismatis is cold in nature, can expel the heat-evil, clearly mutually fire; Poria then can heart-spleen boosting, tranquilizing mind; And Polyporus, can only eliminating dampness by diuresis diuresis.Sweet in the mouth; Light; Cold in nature, return kidney; Urinary bladder channel.Function cures mainly: promoting diuresis to eliminate damp pathogen; Expel the heat-evil treating stranguria.Main dysuria; The puckery pain of pyretic stranguria; Edema distension; Have loose bowels; Dizziness due to fluid-retention; Seminal emission.
Pollen Typhae is stopped blooding, and blood stasis dispelling is treating stranguria.Cure mainly for spitting blood, epistaxis, spitting of blood, metrorrhagia, traumatic hemorrhage, amenorrhea stimulates the menstrual flow, breast ventral spine pain, tumbling and swelling, blood strangury and dry pain.Compendium of Material Medica: removing heat from blood and promoting blood circulation, the only all pains of trusted subordinate." herbal classic ": trusted subordinate's frigiopyrexia of bladder, diuresis, hemostasis, repercussive blood.Clothes of a specified duration are made light of one's life by commiting suicide physical strength profiting, and prolong life angle.
Fructus Crataegi is containing multivitamin, Crataegolic acid, tartaric acid, citric acid, malic acid etc., and also containing the mineral such as flavonoid, lactone, saccharide, protein, fat and calcium, phosphorus, ferrum, contained lipolytic enzyme can promote the digestion of fat food.Promote gastric secretion and increase the functions such as gastric enzyme element.The traditional Chinese medical science is thought, Fructus Crataegi has that removing food stagnancyization is stagnant, convergence effect such as dysentery relieving, activating blood circulation to dissipate blood stasis.Cure mainly the diseases such as eating accumulation, chest and diaphragm feeling of fullness, the amenorrhea of hernia blood stasis.Containing the ingredient such as mountain terpenoid and pyrite class in Fructus Crataegi, there is significant blood vessel dilating and hypotensive effect, there is the function strengthening cardiac muscle, arrhythmia, adjusting blood lipid and cholesterol level, Fructus Crataegi has effect of activating blood circulation to dissipate blood stasis, contribute to removing local congestion state, have auxiliary curative effect to traumatic injury; Flavonoid contained by Fructus Crataegi and the substance such as vitamin C, carotene block and reduce the generation of free radical, and the immunity of energy enhancing body, has anti-aging, anticancer effect; Having in Fructus Crataegi relievings asthma reduces phlegm, the composition of anti-bacteria, treatment abdominal pain diarrhea.
Chinese medicine Radix Polygoni Multiflori have Radix Polygoni Multiflori and Radix Polygoni Multiflori Preparata point, direct slicing is used as medicine for Radix Polygoni Multiflori, dries be used as medicine for Radix Polygoni Multiflori Preparata with Semen sojae atricolor liquor after mixing steaming.The function of the two is different: the removing toxic substances of Radix Polygoni Multiflori function, eliminating carbuncle, loosening bowel to relieve constipation, is usually used in treatment scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; The invigorating the liver and kidney of Radix Polygoni Multiflori Preparata function, benefiting essence-blood, black beard and hair, bone and muscle strengthening, for blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body void etc.Radix Polygoni Multiflori Preparata of the present invention is the good merchantable brand of invigrating kidney.
Herb Gynostemmae Pentaphylli finds through modern medicine study, Herb Gynostemmae Pentaphylli principle active component is polysaccharide, flavonoid, saponins and microelement kind, its effect mainly promotes body fat class substance metabolism, nutrition human body cell, there is good detoxicating, relieving inflammation effect simultaneously, be widely used in hyperlipidemia, fatty liver, obesity, constipation, insomnia, hepatitis B, the treatment of chronic airway inflammation (pharyngolaryngitis, gastroenteritis etc.) and health care.
Fructus Tribuli toil, temperature.Loose wind, improving eyesight, the therapeutic method to keep the adverse QI flowing downwards, promoting the circulation of blood.Control headache, itching over the body, conjunctival congestion swells nebula, fullness in the chest, cough with dyspnea, lump in the abdomen, and breast is difficult, carbuncle, scrofula.Suppressing the hyperactive liver; Resolving depression; Dispelling pathogenic wind for improving eyesight.Main headache; Dizzy; Distending pain in the chest and hypochondrium; Distending pain of the breast; Breast closes obstructed; Amenorrhea; Cataract; Rubella pruritus; Vitiligo; Skin ulcer cellulitis; Scrofula." herbal classic ": " main stagnant blood, broken paralysis knot gathers, and sore throat, breast is difficult.″。" not Lu ": " main health pruritus due to wind pathogen, headache, cough with dyspnea impairing the lung, consumptive lung disease, only tired, the therapeutic method to keep the adverse QI flowing downwards; Children's's head sore, the cloudy Huang of carbuncle, can rub powder." " property of medicine opinion ": " controls all wind scrofula infectionss, and broken stagnated blood, treat vomiting pus, main difficult labour, goes scorching.″
Fructus Gardeniae is Chinese medicine, belongs to the 1st batch of medicine-food two-purpose resource that Ministry of Public Health is promulgated, has the effects such as hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, hemostasis, detumescence, is usually used in the diseases such as treatment icterohepatitis, bruise, hypertension, diabetes at tcm clinical practice.Cure mainly calentura vexed; Liver-fire conjunctival congestion; Headache; Jaundice due to damp-heat; Stranguria; Dysentery hematuria; Aphtha of the mouth and tongue; Sore swollen toxin; Sprain and swell and ache.This product has very large curative effect to conjunctival congestion and swelling pain.These product rush down clearly three burnt pathogenic heats, can treating the liver gallbladder burning hot on the conjunctival congestion and swelling pain of attacking, often join Radix Et Rhizoma Rhei use, as Fructus Gardeniae soup " Shengji Zonglu ".
Fructus Arctii Chinese medicine name.For the dry mature fruit of Compositae biennial herb plant Fructus Arctii (formal name used at school: ArctiumlappaL.).Life is used or is fried use, and the used time smashs to pieces.There is dispelling wind and heat pathogens, lung qi dispersing rash, sore-throat relieving eliminating stagnation, effect of removing toxic substances and promoting subsidence of swelling.Belong to wind-heat-dispersing medicinal in diaphoretic medicine.Modern study, Fructus Arctii also can be used for preventing and treating diabetic nephropathy; The arctigenin that Arctium lappa fruit generates through hydrolysis containing arctigenin has active anticancer.
The root of Radix Scutellariae is used as medicine, bitter in the mouth, cold in nature, has heat clearing and damp drying, eliminating fire and detoxication, hemostasis, the effect such as antiabortive.Cure mainly the diseases such as epidemic febrile disease, upper respiratory tract infection, cough due to lung-heat, damp and hot jaundice, pneumonia, dysentery, hemoptysis, conjunctival congestion, frequent fetal movement, hypertension, carbuncle furuncle.The clinical antibiotic property of Radix Scutellariae is better than Rhizoma Coptidis, and does not develop immunity to drugs.
Radix Puerariae, Chinese medicine name.For the dry root of legume pueraria lobata, practise and claim Herba Gelsemii Elegantis.Autumn, season in winter two excavate, and take advantage of fresh-cut and become sheet or fritter; Dry.Sweet, pungent, cool.There is expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst, the merit of yang invigorating antidiarrheal.Be usually used in exterior syndrome heating, stiff nape and back, measles without adequate eruption, calentura is thirsty, and the deficiency of YIN is quenched one's thirst, diarrhea of heat type hematodiarrhoea, diarrhea due to hypofunction of the spleen.
Stigma Maydis sweet in the mouth, light, property is put down.Return bladder, liver, gallbladder meridian.There is inducing diuresis to remove edema; Effect of liver heat removing function of gallbladder promoting.Main edema, dribbling urination, jaundice, cholecystitis, cholelithiasis, hypertension, diabetes, galactostasis." the southern regions of the Yunnan Province book on Chinese herbal medicine ": the wide intestinal therapeutic method to keep the adverse QI flowing downwards.Control married woman's breast knot, galactostasis, congestion and swelling pain, heating of being afraid of cold, headache body is stranded." south of the Five Ridges gather medicinal herbs record ": decoct soup with Carnis Sus domestica and control diabetes.Control again dribbling urination sandstone, bitter unbearably painful, decoct soup and be taken in small doses at short intervals." conventional glossary of Herbs and Drugs among the people ": can reduce blood pressure, inducing diuresis to remove edema.Control nose bleeding, redly to collapse." Traditional Chinese Medicine in Sichuan will ": clearing away heat from blood, diuresis.Harness the Yellow River subcutaneous ulcer, wind heat, eruption, spits blood and redly to collapse.
Herba Artemisiae Scopariae all herbal medicine, can flu-prevention, control the diseases such as heatstroke, flu, headache heavy sensation of the body, stomachache, vomiting, chest and diaphragm distension, vapour lock dyspepsia, food stagnation of child abdominal distention, diarrhoea, menorrhagia, bleeding not during menses, skin itching and edema, function is delivered in its heat radiation, is especially better than Herba Menthae.Herb can carry aromatic oil again, fresh stem and leaf oil-containing 0.07-0.2%, scapus leaf oil-containing 0.15-4%, proportion (15 DEG C) 0.868-0.910 of oil, optical rotation (20 DEG C)-20 °-70 °, alcohol content (in cephrol) 2-3%, containing phenol amount (in thymol) about containing 7%, except for except preparing essence, be also used as distillers yeast batching.In addition it is again good nectariferous plant.Herba Artemisiae Scopariae clearing away heat-damp and promoting diuresis; Jaundice eliminating.Cure mainly: the yellow hepatitis of jaundice, dysuria, eczema pruritus, infectiousness etc. the effects such as pharmaceutical research has function of gallbladder promoting, liver function protecting, antipyretic, antiinflammatory, blood fat reducing, blood pressure lowering, coronary dilating.
Radix Trichosanthis is the root of cucurbitaceous plant Chinese juniper beach wormwood, is a kind of Chinese medicine, and be clearing away heat-fire class medicine, its concrete effect is clearing away heat-fire, promoting the production of body fluid to quench thirst, and evacuation of pus is subsided a swelling.Cure mainly: control calentura thirsty, quench one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid flaccidity.For treatment diabetes, conventional it and drugs for nourishing yin with the use of, to reach the effect for the treatment of both the principal and secondary aspects of a disease." book on Chinese herbal medicine converge with speech ": Radix Trichosanthis, it is hot and suffocating to move back the five internal organs, and as heart-fire is contained and dry tongue and mouth, lung-fire is contained and pharyngeal swelling sore throat, and spleen-fire is contained and dispute tooth swells, and phlegm-fire is contained and cough is not peaceful.If the side of body of liver-fire is swollen migratory arthralgia caused by wind, the hectic fever due to YIN-deficiency dysphoria with smothery sensation of kidney fire, or carbuncle is not burst, and pyretic toxicity does not fall apart, or five types of jaundice yellow skin and eye, and if if little water drenches puckery, be caused by all burning hot pent-up, phlegm-fire, falls in only this agent energy relieving stagnation, and can control it.Its property is sweet cold again, kindly can control thirsty, and control empty thirsty from tonic, control fire from the medicine of a cold nature thirsty, control yearningly strongly fragrant from gas medicine, controlling excessive thirst from blood medicine, is control thirsty key medicine also.
Herba Lysimachiae sweet in the mouth, micro-hardship, cool in nature.Return liver, gallbladder, kidney, urinary bladder channel.Effect: Herba Lysimachiae is a kind of frequently seen plants, and be a kind of Chinese crude drug, his primary efficacy can prevent calculus and cholagogic and lithagogue to say exactly has very good treatment and preventive effect to calculus, relieving stranguria by diuresis; Heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling, eliminating damp-heat, Sha Lin, urinate and puckeryly to have a pain, jaundice dark coloured urine, carbuncle furuncle, cures mainly liver and gall and urinary system calculus; Pyretic stranguria; Oedema due to nephritis; Jaundice due to damp-heat; Sore carbuncle; Venom; Traumatic injury.
Herba Hedyotidis Diffusae cures mainly: dyspnea and cough due to lung-heat; Laryngopharynx swelling and pain; Intestinal carbuncle; Furuncle and phyma skin infection; Venom; The puckery pain of pyretic stranguria; Edema; Dysentery; Intestinal is scorching; Jaundice due to damp-heat; Be good at the multiple cancerous protuberance for the treatment of.Its patent medicine bitter in the mouth, light, cold in nature.Primary efficacy is heat-clearing and toxic substances removing, medicinal powder for relieving pain knot, promoting urination to remove dampness.Outstanding kind treatment all kinds inflammation.In clinical practice, if find, Herba Hedyotidis Diffusae compatibility is proper, can treat various diseases.
Herba Centellae Classification system Centellaasiatica (L.) Urban, has heat-clearing and toxic substances removing, inducing diuresis and reducing edema, nourishing, antiinflammatory, quelling effect.Deep skin cell can be stimulated to substitute.Herba Centellae can be compacted epidermis and corium coupling part, and skin can be made to limber up, and contributes to solving cutis laxa phenomenon, makes skin smooth flexible; Promote that collagen protein is formed in skin corium, makes fibrin regenerate, reconnects, skin is reached compact smooth effect.Also can help impaired organization healing and consolidation skin.Can to promote between epidermis with corium close is connected, the increase of adipose cell can be suppressed again, prevent hydroderma, occur fat.
Herba Portulacae (Classification system: PortulacaoleraceaL.) is Portulacaceae annual herb plant.Plump succulence, without hair, high 10 ~ 30cm, is born in the area without shade such as roadside, field and ruins, flower garden.All there is distribution domestic various places.This kind is medicine food dual purpose plant.Herb hyoscine, has clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, antiinflammatory, quenches the thirst, diuresis; Seed improving eyesight.Modern study, Herba Portulacae is also containing abundant SL3 fatty acid and vitamin A sample material.SL3 fatty acid forms cell membrane, especially brain cell membrane and the necessary material of eye cell membrane; Vitamin A sample substance maintains epithelial tissue as skin, cornea and conjunctival normal function, participates in the synthesis of rhodopsin, strengthens retinal photoreceptor performance, also participates in many oxidizing processs in body.
Specific embodiment 1:
Gather when 6-8 Spica Prunellae in middle of the month fruit ear is brownish red, removing impurity, dries, and raw use, Jiang Qipao enters ethanol extraction or extraction.
Again by all the other raw material Fructus Gardeniaes, Pollen Typhae, Herba Portulacae, the Radix Rehmanniae, Radix Scutellariae, Radix Puerariae, Herb Gynostemmae Pentaphylli, the Fructus Sophorae, Pericarpium Citri Reticulatae, Stigma Maydis, Herba Artemisiae Scopariae, Fructus Crataegi, Radix Trichosanthis, Fructus Arctii, Herba Lysimachiae, Fructus Tribuli, Herba Hedyotidis Diffusae, Herba Centellae, pulverizes, and extracting solution is made in extraction or extraction.
Two kinds of extract mixing, ultraviolet radiation for sterilizing and disinfecting is bottled.
Specific embodiment 2:
Gather when 6-8 Spica Prunellae in middle of the month fruit ear is brownish red, removing impurity, dries, raw use, general 5000g, steeped in the ethanol of 5-10 times amount after roguing chopping, medicated powder is equipped with in lid stainless steel cask, adds 70% ethanol, quality is 0.8-1 times of coarse powder, stir, moistening airtight placement more than 1 hour, makes abundant expansion; Drug sample after moistening expansion is mixed pine by filter plate gauze bag parcel again bottom percolator after paving does loose, then powder is contained with rustless steel spoon, uniform loading percolator, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitable pressurization, medicated powder must not load 2/3 eminence exceeding percolator; Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, then slowly add 70% ethanol; Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed and be generally 1000g medical material outflow 2 ~ 3ml per minute, filtrate puts into liquid container, and pours ethanol time emptying into liquid container; Percolate is merged and leaves standstill.
Get other raw material Fructus Gardeniae 1500g, Pollen Typhae 1500g, Herba Portulacae 1500g, Radix Rehmanniae 1500g again, Radix Scutellariae 1500g, Radix Puerariae 1500g, Herb Gynostemmae Pentaphylli 1500g, Fructus Sophorae 1500g, Pericarpium Citri Reticulatae 1500g, Stigma Maydis 1500g, Herba Artemisiae Scopariae 1500g, Fructus Crataegi 1500g, Radix Trichosanthis 1500g, Fructus Arctii 1500g, Herba Lysimachiae 1500g, Fructus Tribuli 1500g, Herba Hedyotidis Diffusae 1500g, Herba Centellae 1500g, clean and dry, in 70 DEG C of baking ovens, dry 8-12h, take out and be placed in cooling in drying baker, pulverized 80-100 mesh sieve with pulverizer; To be soaked the particulate matter that sieves in water 12 hours, then put into extraction pot heated and boiled 1 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, and heated and boiled half an hour third time, filter, heating is concentrated into paste, stand for standby use.Paste extract is placed in 70-90% ethanol and soaks 1-2 hour, 60 DEG C-70 DEG C are heated in water-bath, lixiviate 2h, every 10min stirs once, by filtered through gauze, 50-60% ethanol is added in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, be condensed into pasty state filtrate.
Insert in concentrating under reduced pressure tank by two kinds of extracting solution, decompression recycling ethanol, being concentrated into liquor strength is 0.1g crude drug/mL, when sucking filtration to the relative density of filtrate is 20 DEG C 1.06; Above-mentioned filtrate, after the macroporous adsorptive resins absorption that volume is 10L, with deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, mediation Mel, bottles after ultraviolet ray sterilization bactericidal.
Specific embodiment 3:
Gather when 6-8 Spica Prunellae in middle of the month fruit ear is brownish red, removing impurity, dries, raw use, general 4500g.80-100 mesh sieve was pulverized with pulverizer; To be soaked the particulate matter that sieves in water 12 hours, then put into extraction pot heated and boiled 1 hour, filter, filtrate is for subsequent use; Filtering residue adds water, and second time heating, boils 45 minutes, and filter, filtrate is for subsequent use; Filtering residue adds water again, and heated and boiled half an hour third time, filter, heating is concentrated into paste, stand for standby use.Paste extract is placed in 70-90% ethanol and soaks 1-2 hour, in water-bath, be heated to 60 DEG C-70 DEG C, lixiviate 2h, every 10min stirs once, by filtered through gauze, add 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, and every 10min stirs once, filtered through gauze, merge lixiviating solution, be condensed into pasty state filtrate, stand-by.
Get other raw material Fructus Gardeniae 1100g again, Pollen Typhae 1200g, Herba Portulacae 1100g, Radix Rehmanniae 1100g, Radix Scutellariae 1100g, Radix Puerariae 1100g, Herb Gynostemmae Pentaphylli 1100g, Fructus Sophorae 1200g, Pericarpium Citri Reticulatae 1100g, Stigma Maydis 1100g, Herba Artemisiae Scopariae 1100g, Fructus Crataegi 1100g, Radix Trichosanthis 1200g, Fructus Arctii 1100g, Herba Lysimachiae 1100g, Fructus Tribuli 1100g, Herba Hedyotidis Diffusae 1100g, Herba Centellae 1100g, get other raw materials and clean roguing, steep in the ethanol of 5-10 times amount, medicated powder is equipped with in lid stainless steel cask, add 70% ethanol, quality is 0.8-1 times of coarse powder, stir, moistening airtight placement more than 1 hour, make abundant expansion, drug sample after moistening expansion is mixed pine by filter plate gauze bag parcel again bottom percolator after paving does loose, then powder is contained with rustless steel spoon, uniform loading percolator, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitable pressurization, medicated powder must not load 2/3 eminence exceeding percolator, medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, then slowly add 70% ethanol, air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed and be generally 1000g medical material outflow 2 ~ 3ml per minute, filtrate puts into liquid container, and pours ethanol time emptying into liquid container, percolate is merged and leaves standstill.
Insert in economic benefits and social benefits vacuum concentrator for two kinds that above-mentioned steps are obtained, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Then add dextrin, bottle after ultraviolet sterilization.
Pharmacological toxicity is tested
One, test material:
(1) laboratory animal: mouse NIH, body weight 25-28g, male and female half and half; Rats Wistar body weight 130-160g, male and female half and half, the feedstuff of rat, mice is provided by Shandong medical college animal experimental center.
(2) test medicine:
1, medicine of the present invention: the tea that embodiment 2 is made, applies with distilled water diluting during three batch equal amount of mixture experiments.
2, positive control medicine: JINGUI SHENQI WAN, commercially available.
Two, test method and result:
(1) get the healthy mice 80 of body weight 25-28g, female, hero half and half, is divided into four groups respectively by sex and body weight, often organizes 20.1, take medicine of the present invention for 2,3 groups, dosage is respectively 8.6g crude drug/kg/d, 6.4g crude drug/kg/d, 4.2g crude drug/kg/d, and take positive control drug JINGUI SHENQI WAN for the 4th group, dosage is 6g crude drug/kg/d, is used in conjunction 15 days.
Result of the test: 1,2,3 groups of mices obviously strengthen than 4 groups of mice sexual excitation degree, the number of copulations of 1,2,3 group of mice average every day increases by 3 times than the number of copulations of 4 groups of mices.
Result of the test shows that medicine of the present invention has obvious excitation to central nervous system, thus medicine of the present invention for adjustment human body function equilibrium, QI invigorating, enrich blood, slow down aging strengthens metabolism, neurolysis, sexual hypofunction has treatment foundation.
Animal acute toxicity test of the present invention
One, test material
(1) animal mouse NIH kind male and female half and half, body weight 20-22g, are provided by Shandong medical college Animal Lab..
(2) test medicine: the tea that the present invention is made, is diluted with distilled water into suspension.
Two, test method and result:
Mice maximum tolerance determination: get healthy mice 32, male and female half and half, divided three groups within 24 hours, and only, gross weight 1.8ml, is equivalent to crude drug in whole 4.0g to each 0.6ml/ of gavage intestinal, i.e. 100g crude drug/kg/d, is equivalent to 857 times of clinical 65 kilograms of people.After mice administration routinely feedstuff within 12 days, have no animal dead and do not go out, existing toxic reaction.Therefore prove, medicine of the present invention has no side effect, and clinical practice is safe and reliable.
The long-term toxicity test for animals of pharmaceutical composition of the present invention
One, test material and method
(1) test medicine: the tea that the embodiment of the present invention is made.
(2) laboratory animal, healthy rat Wistar, body weight 100-130g, 140 male and female half and half, by sex and body weight random packet, four groups, often organize 35.1, take test medicine for 2,3 groups, dosage is respectively 9.6/kg/d, 6.4/kg/d, 3.2/kg/d.4 groups contrast to the distilled water of respective volume amount, the equal gavage enteral administration of rat, often organize and be once used in conjunction 6 months, put to death half, and all death in 12 days is observed in remaining 1/2 drug withdrawal.
Two, test index
(1) general status comprises body weight, diet, emotion, movable energy.
(2) hemogram checking: red blood cell count(RBC), numeration of leukocyte, platelet count, hemogram etc., quantitative hemoglobin counts.
(3) biochemical analysis, serum albumin quantitatively, cholesterol, blood sugar quantitative.
(4) pathologic diagnosis: get half animal after experimental result and weigh, sacrificed by decapitation, gets blood, solution is treated others for earnest simultaneously, liver, kidney, lung, brain, spleen, gastrointestinal, bladder, adrenal gland do pathologic diagnosis.
Three, result of the test: show through rat chronic toxicity test, with the heavy dose of coloclysis of the present invention six months, increases the growth of rat, body weight, all has no side effect to brain, Liver and kidney function.Do not find that infringement changes to each histoorgan of rat, blood circulation, medication group compares no significant difference with matched group.
Pharmacodynamic experiment:
Description of test: Spica Prunellae is traditional antilipemic Chinese herbal medicine, its pharmacological action again be familiar with by people; Current research shows, the effective ingredient (as polysaccharide, quinones etc.) of Spica Prunellae has blood fat reducing and antivirus action.This studies property hyperlipemia and Atherosclerosis Model by experiment, inquires into the effect for reducing fat of Polysaccharides from Prunella vulgaris L and the impact on experimental atherosclerosis thereof.
Pharmacodynamic experiment:
1 materials and methods
1.1 material
1.1.1 medicine health care oral liquid of the present invention (prepared by preparation method 2, be prepared into the reagent containing crude drug 0.2g/ml), is provided by preparation section of the court; Metformin hydrochloride (Shanghai Fahrenheit pharmacy).
1.1.2 animal Kunming mouse 96, male and female half and half, body weight (22.5 ± 2.5) g, provides by Shandong University's animal experimental center.
1.1.3 reagent and instrument streptozotocin (STZ) (SERVER company), purchased from magnificent company.Electronic balance AB204-WO type (prunus mume (sieb.) sieb.et zucc. Teller-Tuo company limited of Switzerland); Hitachi 7150 type automatic clinical chemistry analyzer (Japan).
1.2 method
1.2.1 modeling and grouping diabetes: animal is bought back, after adaptability feeds 1 week, be divided into normal non-diabetic group 8 and experimental group 40 at random, experimental group fasting 12 hours before modeling, modeling adopts the injection of STZ55mg/kg disposable celiac, within after administration 24 hours, survey blood glucose, glucose in urine, for three days on end, glucose in urine is qualitative +++ more than, blood glucose value is more than 16.5mmol/L, and continue constant person, be defined as diabetes and formed.
Modeling success mice is divided into 5 groups, the high, medium and low concentration group of model control group, metformin group, health care oral liquid of the present invention at random.
Hyperlipemia: animal is bought back, after adaptability feeds 1 week, be divided into normal non-hyperlipemia group 8 and experimental group 40 at random, experimental group fasting 12 hours before modeling, modeling gives more than 1 week containing 1% cholesterol, the high lipoprotein emulsion of 20% Adeps Sus domestica, 2% sodium cholate, 1% propylthio pyrimidine, every day 1 time, continuous 7 days.Modeling success mice is divided into 5 groups, the high, medium and low concentration group of model control group, metformin group, decocting liquid of the present invention at random.
1.2.2 administration and assay method Normal group and model control group (the isopyknic normal saline of ig); Metformin hydrochloride group (ig, 0.20g/kg); Health care oral liquid group of the present invention (ig every day decocting liquid 2.0g/kg of the present invention respectively, 3.0g/kg, 4.0g/kg).Each group of difference gastric infusion, 1 time/d, continuous 30 days.12h fasting before last administration, 2h after administration, plucks eye and gets blood, measures blood glucose and blood fat with automatic clinical chemistry analyzer.
1.2.3 all data of statistical procedures represent with "-χ ± S ", data acquisition SPSS11.5 statistical software analyzing and processing, if compare homogeneity of variance one way analysis of variance between many groups, if heterogeneity of variance rank test, compare and use paired t-test before and after in group.
2 results
As shown in Table 1, the high, medium and low concentration group of decocting liquid of the present invention all significantly can reduce the blood glucose of hyperglycemia mouse model, compares with model control group, and difference has statistical significance (P < 0.05) in 2.1 blood sugar lowering experiments.
Table 1 health care oral liquid of the present invention is on the impact (-χ ± S) of mouse blood sugar
Note: compare with Normal group, Δ Δ P < 0.01; Compare with model control group, * P < 0.05, * * P < 0.01; NS, normal saline.
2.3 blood fat reducing experiment as shown in Table 2, the high, medium and low concentration of health care oral liquid of the present invention all obviously can reduce TC, TG content of hyperlipemia mice model, compare with model control group, difference has statistical significance (P < 0.05, P < 0.01).
Table 2 the present invention is on the impact (χ ± S) of lipid of mice
Note: compare with Normal group, Δ Δ P < 0.01; Compare with model control group, * P < 0.05, * * P < 0.01; NS, normal saline.
3 discuss
In recent years, along with improving constantly of people's living standard, the disease incidence such as diabetes, coronary heart disease increases day by day.In the blood of people, lipid contained in blood plasma is called blood fat, comprise cholesterol, cholesterol ester, triglyceride, phospholipid and not esterified fat acid etc. several.When cholesterol, triglyceride etc. all exceed normal value, be then referred to as hyperlipemia.Hyperlipemia is atherosclerotic Main Etiological Factors.Often cause serious consequence, as coronary heart disease, diabetes, cerebrovas-cularaccident, intractable hypertension and the nephrotic syndrome, pancreatitis, calculosis, fatty liver etc. because invading vitals.Arteriosclerotic generation and development, have close relationship with Hyperlipemia.Chinese herbal medicine effect is stablized, few side effects, and research has the Chinese herbal medicine of hypoglycemic lipid-lowering effect, can provide more method for clinical treatment diabetes, hyperlipemia.
Claims (10)
1. a Spica Prunellae antilipemic healthy oral liquid, it is characterized in that, described Spica Prunellae antilipemic healthy oral liquid comprises the crude drug of following weight portion: Spica Prunellae 10 ~ 50 parts, Fructus Gardeniae 10 ~ 20 parts, Pollen Typhae 10 ~ 20 parts, Herba Portulacae 10 ~ 20 parts, 10 ~ 20 parts, the Radix Rehmanniae, Radix Scutellariae 10 ~ 20 parts, Radix Puerariae 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, the Fructus Sophorae 10 ~ 20 parts, Pericarpium Citri Reticulatae 10 ~ 20 parts, Stigma Maydis 10 ~ 20 parts, Herba Artemisiae Scopariae 10 ~ 20 parts, Fructus Crataegi 10 ~ 20 parts, Radix Trichosanthis 10 ~ 20 parts, Fructus Arctii 10 ~ 20 parts, Herba Lysimachiae 10 ~ 20 parts, Fructus Tribuli 10 ~ 20 parts, Herba Hedyotidis Diffusae 10 ~ 20 parts, Herba Centellae 10 ~ 20 parts.
2. Spica Prunellae antilipemic healthy oral liquid according to claim 1, it is characterized in that, described Spica Prunellae antilipemic healthy oral liquid comprises the crude drug of following weight portion: Spica Prunellae 10 ~ 30 parts, Fructus Gardeniae 10 ~ 15 parts, Pollen Typhae 10 ~ 15 parts, Herba Portulacae 10 ~ 15 parts, 10 ~ 15 parts, the Radix Rehmanniae, Radix Scutellariae 10 ~ 15 parts, Radix Puerariae 10 ~ 15 parts, Herb Gynostemmae Pentaphylli 10 ~ 15 parts, the Fructus Sophorae 10 ~ 15 parts, Pericarpium Citri Reticulatae 10 ~ 15 parts, Stigma Maydis 10 ~ 20 parts, Herba Artemisiae Scopariae 10 ~ 20 parts, Fructus Crataegi 10 ~ 20 parts, Radix Trichosanthis 10 ~ 20 parts, Fructus Arctii 10 ~ 20 parts, Herba Lysimachiae 10 ~ 20 parts, Fructus Tribuli 10 ~ 20 parts, Herba Hedyotidis Diffusae 10 ~ 20 parts, Herba Centellae 10 ~ 20 parts.
3. Spica Prunellae antilipemic healthy oral liquid according to claim 1, it is characterized in that, described Spica Prunellae antilipemic healthy oral liquid comprises the crude drug of following weight portion: Spica Prunellae 10 ~ 50 parts, Fructus Gardeniae 10 ~ 20 parts, Pollen Typhae 10 ~ 20 parts, Herba Portulacae 10 ~ 20 parts, 10 ~ 20 parts, the Radix Rehmanniae, Radix Scutellariae 10 ~ 20 parts, Radix Puerariae 10 ~ 20 parts, Herb Gynostemmae Pentaphylli 10 ~ 20 parts, the Fructus Sophorae 10 ~ 20 parts, Pericarpium Citri Reticulatae 10 ~ 20 parts, Stigma Maydis 10 ~ 15 parts, Herba Artemisiae Scopariae 10 ~ 15 parts, Fructus Crataegi 10 ~ 15 parts, Radix Trichosanthis 10 ~ 15 parts, Fructus Arctii 10 ~ 15 parts, Herba Lysimachiae 10 ~ 15 parts, Fructus Tribuli 10 ~ 15 parts, Herba Hedyotidis Diffusae 10 ~ 15 parts, Herba Centellae 10 ~ 15 parts.
4. the preparation method of Spica Prunellae antilipemic healthy oral liquid according to any one of claims 1 to 3, it is characterized in that, the preparation process of described oral liquid comprises:
A. gather when Spica Prunellae fruit ear is brownish red when summer, removing impurity, dries, raw use;
B. the Spica Prunellae dried is pulverized, soaked ethanol heating extraction;
C. by other raw material pulverizing described, immersion ethanol extraction;
D. mixed by other raw material extracting solution concentrated with the Spica Prunellae extracting solution prepared, sterilizing is prepared into oral solutions.
5. the preparation method of Spica Prunellae antilipemic healthy oral liquid according to claim 4, is characterized in that, in described step a, between the 6-8 month, when Spica Prunellae fruit ear is brownish red, plucks, dry in the sun, allows it parch, for subsequent use.
6. the preparation method of Spica Prunellae antilipemic healthy oral liquid according to claim 4, is characterized in that, in described step b, Spica Prunellae chopping is placed in 70-90% ethanol and soaks 1-2 hour, in water-bath, be heated to 60 DEG C-70 DEG C, lixiviate 2h, every 10min stirs once, by filtered through gauze, adds 50-60% ethanol in residue, 60 DEG C-70 DEG C are continued lixiviate 2h, every 10min stirs once, filtered through gauze, merges lixiviating solution, be condensed into pasty state filtrate, stand-by.
7. the preparation method of Spica Prunellae antilipemic healthy oral liquid according to claim 4, is characterized in that, in described step c, all the other raw materials are cleaned roguing, put into 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.05 filtrate.
8. the preparation method of Spica Prunellae antilipemic healthy oral liquid according to claim 4, is characterized in that, in described steps d, two kinds of extracting solution are inserted in concentrating under reduced pressure tank, decompression recycling ethanol, being concentrated into liquor strength is 0.1g crude drug/mL, when sucking filtration to the relative density of filtrate is 20 DEG C 1.06; Above-mentioned filtrate, after the macroporous adsorptive resins absorption that volume is 10L, with deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, mediation Mel, bottles after ultraviolet ray sterilization bactericidal.
9. the preparation method of Spica Prunellae antilipemic healthy oral liquid according to any one of claims 1 to 3, it is characterized in that, the preparation process of described Spica Prunellae oral liquid comprises following aspect:
A. gather when Spica Prunellae fruit ear is brownish red when summer, removing impurity, dries, raw use;
B. the Spica Prunellae dried pulverizing, immersion ethanol are added extraction heat;
C. by other raw material pulverizing described, immersion ethanol extraction;
D. mixed by other raw material extracting solution concentrated with the Spica Prunellae extracting solution prepared, sterilizing is prepared into oral solutions.
10. the preparation method of Spica Prunellae antilipemic healthy oral liquid according to claim 9, it is characterized in that, in described step b, the extraction step of Spica Prunellae is: get Spica Prunellae chopping for subsequent use, steep in the ethanol of 5-10 times amount, medicated powder is equipped with in lid stainless steel cask, add 70% ethanol, quality is 0.8-1 times of coarse powder, stirs, moistening airtight placement more than 1 hour, makes abundant expansion; Drug sample after moistening expansion is mixed pine by filter plate gauze bag parcel again bottom percolator after paving does loose, then powder is contained with rustless steel spoon, uniform loading percolator, dress 10-12 cm thick, even by T-bar pressure, then press aforesaid operations, loading in layer, suitable pressurization, medicated powder must not load 2/3 eminence exceeding percolator; Medicated powder face upper cover rustless steel orifice plate fastens, and opens the baiting valve below percolator, and puts a container, then slowly add 70% ethanol; Air between medicated powder powder to be discharged, and have ethanol to flow out about about 20L, close baiting valve, cover cylinder of filtering, dipping 24 hours, then open baiting valve and carry out percolation, control percolation speed and be generally 1000g medical material outflow 2 ~ 3ml per minute, filtrate puts into liquid container, and pours ethanol time emptying into liquid container; Percolate is merged and leaves standstill.
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CN105434858A (en) * | 2015-12-31 | 2016-03-30 | 青岛安倍康生物医药技术有限公司 | Method for producing traditional Chinese medicine spot-removing oral liquid and oral liquid |
CN106578212A (en) * | 2016-12-10 | 2017-04-26 | 青岛嘉瑞生物技术有限公司 | Salicornia Bigelovii Torr. healthcare beverage helpful for reducing blood pressure |
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US11554133B2 (en) | 2017-03-16 | 2023-01-17 | Kracie Holdings, Ltd. | Bile acid synthesis promoter, composition for promoting bile acid synthesis and food composition for promoting bile acid synthesis |
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