CN105169278A - Dandelion oral liquid capable of protecting liver and benefiting gallbladder and preparation method thereof - Google Patents

Dandelion oral liquid capable of protecting liver and benefiting gallbladder and preparation method thereof Download PDF

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CN105169278A
CN105169278A CN201510658350.1A CN201510658350A CN105169278A CN 105169278 A CN105169278 A CN 105169278A CN 201510658350 A CN201510658350 A CN 201510658350A CN 105169278 A CN105169278 A CN 105169278A
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parts
radix
herba
oral liquid
herba taraxaci
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赵玉妹
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Qingdao Hengbo Instrument Co Ltd
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Qingdao Hengbo Instrument Co Ltd
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Abstract

The invention provides dandelion oral liquid capable of protecting the liver and benefiting the gallbladder. The oral liquid is characterized by being prepared from, by weight, 10-50 parts of dandelion, 10-20 parts of herba artemisiae capillariae, 10-20 parts of serrate rabdosia herbs, 10-20 parts of selfheals, 10-20 parts of radix bupleuri, 10-20 parts of radix paeoniae alba, 10-20 parts of angelica sinensis, 10-20 parts of corn stigma, 10-20 parts of rhizoma imperatae, 10-20 parts of rhizoma polygoni cuspidati, 10-20 parts of radix aucklandiae, 10-20 parts of fructus schizandrae, 10-20 parts of semen boitae, 10-20 parts of lonicera japonica, 10-20 parts of radix trichosanthis, 10-20 parts of curcuma zedoary, 10-20 parts of herba ecliptae, 10-20 parts of radix polygoni multiflori preparata, 10-20 parts of semen plantaginis, 10-20 parts of fructus gardeniae, 10-20 parts of rehmannia roots and 10-20 parts of herba andrographitis. According to the dandelion oral liquid capable of protecting the liver and benefiting the gallbladder and a preparation method thereof, due to the fact that the extraction technique of the traditional Chinese medicine is greatly improved, the toxic ingredients in the traditional Chinese medicine is reduced to the minimum to be capable of being absorbed by a human body, and the utilization rate of the traditional Chinese medicine is greatly improved.

Description

Herba Taraxaci oral liquid of a kind of hepatic cholagogic and preparation method thereof
Technical field
The present invention relates to the medical health product containing deriving from plant, animal or raw mineral materials, particularly a kind of Herba Taraxaci oral liquid and preparation method thereof of hepatic cholagogic.
Background technology
The traditional Chinese medical science thinks that hepatitis belongs to damp-heat accumulation more and causes bile to leak to invade and the place such as skin, sclera and yellow cellulitis occurs, and because of the liver failing to maintain the normal flow of QI, dysfunction of the spleen in transportation and the symptom such as inappetence, nausea and vomiting occurs, treatment should be taked the method for " clearing away heat-damp and promoting diuresis, depressed liver-energy dispersing and function of gallbladder promoting ".
We are through the clinical observation of 77 routine acute Jaundice Jaundice application dandelion preparation treatments, tentatively can find out that Herba Taraxaci has certain effect to jaundice eliminating, reduction glutamate pyruvate transaminase, and make in 30 days the acute Jaundice Jaundice patient clinical of 89.6% cure in treatment, be considered to treatment viral hepatitis good medicine on Yunnan and other places, to treat liver and gall curative effect similar to Folium Isatidis.
Pharmacological tests shows, Herba Taraxaci decoct and injection have the effect reducing rat glutamate pyruvate transaminase that carbon tetrachloride causes and raise, and its hepatic injury can be alleviated, have certain choleretic effect, this may be the pharmacological basis that Herba Taraxaci treats acute Jaundice Jaundice.In view of dandelion preparation is to laboratory animal hypophysis cerebri, adrenal gland etc. organize harmless effect, do not find any side effect clinically, and the effect such as medicine source is extensive, has good sterilization, protects the liver, function of gallbladder promoting, be worth its effective ingredient of research further, reform dosage form, expand clinical application range.
Dandelion herb is rich in vitamin A, vitamin C and potassium, also containing ferrum, calcium, vitamin B2, vitamin B1, magnesium, vitamin B6, folic acid and copper.Concrete constituent content mainly moisture, every 60 grams of dandelion herb leaf moisture contents 86%, 1.6 grams, protein, carbohydrate 5.3 grams, heat about has 108.8 kilojoules.Containing multiple health-nutrition compositions such as taraxol, taraxacin, choline, organic acid, inulin in Herba Taraxaci plant.Nature and flavor are sweet, micro-hardship, cold.Return liver, stomach warp.There are the effects such as diuresis, cathartic, jaundice eliminating subcutaneous ulcer, function of gallbladder promoting.Control pyretic toxicity, carbuncle, skin infection, abscess of internal organ, conjunctival congestion and swelling pain, damp and hot, the puckery pain of jaundice, dribbling urination, furuncle swelling toxin, acute mastitis, scrofula, toothache, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection etc.Herba Taraxaci is raw-eaten, stir-fry and eat, cook soup, is the plant of dietotherapeutic.
Herba Taraxaci heat-clearing and toxic substances removing, diuresis eliminating stagnation.Control acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.Tang Materia Medica: housewife's human milk carbuncle." Bencao Tujing ": apply skin ulcer, controls again and dislikes thorn and contact dermatitis." Amplification on Materia Medica addendum ": heat-transformation poison, disappears and dislikes swollen tuberculosis, Detoxicating food-poisoning, loose stagnant gas." the southern regions of the Yunnan Province book on Chinese herbal medicine ": apply all pyogenic infections from tumour or sore, mange tinea skin ulcer; Dispel the wind, disappear all sores, loose scrofula tuberculosis; Stop little having blood in stool, control the five types of stranguria difficulty in urination, sharp bladder." detailed outline ": black beard and hair, strengthening bone and muscle." Bencao Jingshu ": Herba Taraxaci is hidden sweet flat, and its property is nontoxic.When being enter stomach into liver, the key medicine of antipyretic removing heat from blood.Acute mastitis belongs to Liver Channel, and married woman is after row, and Liver Channel is taken charge, therefore housewife's human milk carbuncle breast poison, and should give birth to warm good." book on Chinese herbal medicine is stated ": Herba Taraxaci, Gan Erwei is remaining bitter, is Gan Ping and has the person of being slightly cold concurrently also.Uncommon harmony has to be said: the bright Liver and kidney of sweet flat agent point.' hide this language, then know its enter stomach and double enter Liver and kidney, not so, how removing heat from blood, black beard and hair, dirty to close the blood of appointing in punching? namely be think of, then the so-called kidney channel of eastern wall must user, especially when in the same way, improper only before institute cure mainly to the greatest extent also." book on Chinese herbal medicine newly organized ": Herba Taraxaci, to low-priced and have large merit, does not know to use it by means of common people.The fire that sun is bright, often to setting a prairie fire, with Baihu Tang with pathogenic fire purging, injure one's stomach gas rather.Fire in lid stomach is contained, because stomach sergeant declines also, and pathogenic fire purging and soil more declines.Therefore with from brave soup to rush down stomach-fire, be the extremely suitable of a period of time, and can not rely on for also prolonged.Herba Taraxaci also rushes down the medicine of stomach-fire, but its gas is very flat, can pathogenic fire purging, does not damage soil again, can grow clothes clothes and not hindering for a long time.The fire person that all systems sun is bright, all agent can take it greatly, fire moves back and gastric qi is spontaneous.But the power of its pathogenic fire purging is very micro-, must be multiplex, one or two, few also five, six money, begin loose evil auxiliary positive ear.Or ask, Herba Taraxaci pathogenic fire purging that the fire of each warp failed to see by the fire that antidiarrheal sun is bright, also can disappear to the greatest extent? say, the strongest person of fire, without crossing the bright flame of sun, the bright fire of sun falls, and each through ember without disappearing not to the utmost.Though the medicine of the non-each warp of Herba Taraxaci, and the fire of each warp, see Herba Taraxaci and most volt, namely meaning Herba Taraxaci can disappear the fire of each warp, also without can not be also.Or ask that Herba Taraxaci and Flos Lonicerae are both the thing of eliminating carbuncle infections, two things are who victory after all? husband's Herba Taraxaci stops into bright, lunar two warps of sun, and Flos Lonicerae is not then without through entering, and Herba Taraxaci can not be same as function also with Flos Lonicerae.Right Flos Lonicerae obtains Herba Taraxaci and its merit is larger.
Herba Taraxaci herb is containing taraxasterol, choline, inulin, pectin etc.Containing taraxol, taraxerol, ψ-Portugal's Herba Taraxaci sterol, taraxasterol, β-Amyrin, stigmasterol, cupreol, choline, organic acid, fructose, sucrose, glucose, glycoside and resin, rubber etc. in root.Leaf is containing phylloxanthin, violaxanthin, phylloquinone, vitamin C (50 ~ 70 milligrams/100 grams) and vitamin D (5 ~ 9 milligrams/100 grams).
Containing arnica montana glycol, phylloxanthin and flavoxanthin in spending.Containing cupreol, 5z-bean steroid-7-alkene-3 β-ol, folic acid and vitamin C in pollen.Containing phylloquinone in green calyx.Containing cupreol and β-Amyrin in scape.Again these product containing Coumestrol, riboflavin 1.43 microgram/gram and carotene 7.7 ~ 8.8 milligrams of %.
(1) antibacterial action: this product injection in vitro has stronger bactericidal action to staphylococcus aureus resistance bacterial strain, Hemolytic streptococcus.Also certain bactericidal action is had to Diplococcus pneumoniae, meningococcus, diphtheria corynebacterium, bacillus pyocyaneus, dysentery bacterium, Bacillus typhi etc. and micrococcus catarrhalis.This product alcohol extract 1: 400 can suppress tulase, but decoct 1: 100 is invalid.Its water decoction of 1: 80 can delay ECHO11 viral cytopathic, and ethanol extract (31mg/kg) can kill leptospira, also has inhibitory action to some fungus.Good killing action is had to campylobacter pylori.
(2) lactogenesis: this product leaf has the obstruction dredging newborn vascular, promotes the effect of lactogenic.
(3) antitumor action: the polysaccharide (Tof mono-CFr) extracted in common dandelion, with 40,2,600mg/kgip awards the C3H mouse of inoculation MM46 tumor cell, administration in early stage has no effect, but the next day of the later stage of 11 ~ 20 days and 2 ~ 20 days, administration is then effective.Type anaphylaxis (T mono-DHR) is delayed to tumor cell, in ddy mono-Ehrlich (same tumor) is be with C3H mono-MM46 (syngeneic tumor), its footpad reaction of Tof mono-CFr later stage administration all obviously rises compared with matched group.In ADMC system, Tof mono-CFr, compared with the glycogen of known energy activated macrophage, has stronger activation capability
(4) choleretic effect: foreign study, these product have choleretic effect, clinical treatment chronic gallbladder spasmolytic and calculosis effective.In addition this product still has diuresis stomach invigorating, the effects such as hypocatharsis.
Be medicine three points of poison, Chinese medicine health care product must control dosage well, its toxicity is dropped to minimum.The present invention improves Chinese medicine extraction technology greatly, the toxic component of Chinese medicine is dropped to minimum, can make absorption of human body, greatly improves its utilization rate.Control dose; Strengthen " dose-effect relationship " and " measuring malicious relation " research; Use modern technologies, inside and outside methods combining is evaluated.
Summary of the invention
Technical problem to be solved by this invention is, liver and gall diseases is the commonly encountered diseases frequently-occurring disease of serious harm human health, promotes liver cell regeneration at present and prevent hepatic necrosis without specific medicament.Be medicine three points of poison, Chinese medicine health care product must control dosage well, its toxicity is dropped to minimum.The traditional Chinese medical science thinks that hepatitis belongs to damp-heat accumulation more and causes bile to leak to invade and the place such as skin, sclera and yellow cellulitis occurs, and because of the liver failing to maintain the normal flow of QI, dysfunction of the spleen in transportation and the symptom such as inappetence, nausea and vomiting occurs, treatment should be taked the method for " clearing away heat-damp and promoting diuresis, depressed liver-energy dispersing and function of gallbladder promoting ".Herba Taraxaci decoct and injection have the effect reducing rat glutamate pyruvate transaminase that carbon tetrachloride causes and raise, and can alleviate its hepatic injury, and have certain choleretic effect, this may be the pharmacological basis that Herba Taraxaci treats acute Jaundice Jaundice.In view of dandelion preparation is to laboratory animal hypophysis cerebri, adrenal gland etc. organize harmless effect, do not find any side effect clinically, and the effect such as medicine source is extensive, has good sterilization, protects the liver, function of gallbladder promoting, be worth its effective ingredient of research further, reform dosage form, expand clinical application range.The present invention improves Chinese medicine extraction technology greatly, the toxic component of Chinese medicine is dropped to minimum, can make absorption of human body, greatly improves its utilization rate.
For solving the problems of the technologies described above, the invention provides a kind of Herba Taraxaci oral liquid of hepatic cholagogic, oral liquid described in it comprises the crude drug of following parts by weight: Herba Taraxaci 10 ~ 50 parts, Herba Artemisiae Scopariae 10 ~ 20 parts, Herba Rabdosiae Lophanthoidis 10 ~ 20 parts, Spica Prunellae 10 ~ 20 parts, Radix Bupleuri 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Stigma Maydis 10 ~ 20 parts, Rhizoma Imperatae 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, the Radix Aucklandiae 10 ~ 20 parts, Fructus Schisandrae Chinensis 10 ~ 20 parts, Semen Platycladi 10 ~ 20 parts, Flos Lonicerae 10 ~ 20 parts, Radix Trichosanthis 10 ~ 20 parts, Rhizoma Curcumae 10 ~ 20 parts, Herba Ecliptae 10 ~ 20 parts, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, Semen Plantaginis 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, 10 ~ 20 parts, the Radix Rehmanniae, Herba Andrographis 10 ~ 20 parts.
The Herba Taraxaci oral liquid of described hepatic cholagogic, in oral liquid described in it, the parts by weight of various crude drug can be: Herba Taraxaci 10 ~ 40 parts, Herba Artemisiae Scopariae 10 ~ 15 parts, Herba Rabdosiae Lophanthoidis 10 ~ 15 parts, Spica Prunellae 10 ~ 15 parts, Radix Bupleuri 10 ~ 15 parts, the Radix Paeoniae Alba 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Stigma Maydis 10 ~ 15 parts, Rhizoma Imperatae 10 ~ 15 parts, Rhizoma Polygoni Cuspidati 10 ~ 15 parts, the Radix Aucklandiae 10 ~ 15 parts, Fructus Schisandrae Chinensis 10 ~ 20 parts, Semen Platycladi 10 ~ 20 parts, Flos Lonicerae 10 ~ 20 parts, Radix Trichosanthis 10 ~ 20 parts, Rhizoma Curcumae 10 ~ 20 parts, Herba Ecliptae 10 ~ 20 parts, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, Semen Plantaginis 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, 10 ~ 20 parts, the Radix Rehmanniae, Herba Andrographis 10 ~ 20 parts.
The Herba Taraxaci oral liquid of described hepatic cholagogic, in oral liquid described in it, the parts by weight of various crude drug can also be: Herba Taraxaci 10 ~ 30 parts, Herba Artemisiae Scopariae 10 ~ 20 parts, Herba Rabdosiae Lophanthoidis 10 ~ 20 parts, Spica Prunellae 10 ~ 20 parts, Radix Bupleuri 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Stigma Maydis 10 ~ 20 parts, Rhizoma Imperatae 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, the Radix Aucklandiae 10 ~ 20 parts, Fructus Schisandrae Chinensis 10 ~ 15 parts, Semen Platycladi 10 ~ 15 parts, Flos Lonicerae 10 ~ 15 parts, Radix Trichosanthis 10 ~ 15 parts, Rhizoma Curcumae 10 ~ 15 parts, Herba Ecliptae 10 ~ 15 parts, Radix Polygoni Multiflori Preparata 10 ~ 15 parts, Semen Plantaginis 10 ~ 15 parts, Fructus Gardeniae 10 ~ 15 parts, 10 ~ 15 parts, the Radix Rehmanniae, Herba Andrographis 10 ~ 15 parts.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Herba Taraxaci oral liquid of hepatic cholagogic, it is characterized in that, the preparation process of described oral liquid comprises:
A. the preparation of Herba Taraxaci, as component 1;
B. all the other crude drug described are put into ethanol heating and refluxing extraction 2 times, as component 2;
C. by above-mentioned two kinds of extracting solution components 1 and component also 2-in-1, add Mel after concentrated or dextrin is in harmonious proportion, after disinfection, be prepared into oral liquid bottling.
In described step a, Herba Taraxaci can be plucked, after clean dry, soaked 1-2 hour in the ethanol accounting for its quality 10 times amount, then put into extraction pot heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.06 extractum, heating is concentrated into paste, stand for standby use, becomes component 1 for subsequent use.
In described step b, all the other raw materials described can be steeped and account in its quality 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.06 extractum, heating is concentrated into paste, stand for standby use, becomes component 2.
In described step c, can by component 1 and component 2-in-1 and after, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.36, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Unguentum after concentrated adds Mel or dextrin is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method of Herba Taraxaci oral liquid of hepatic cholagogic, and preparation process can also be:
A. by Herba Taraxaci extracting in water, as component 1;
B. Herba Taraxaci is extracted rear residue to soak together with all the other crude drug described, extract 2 times as component 2;
C. component 1, component 2 are mixed concentrated after add Mel and be in harmonious proportion, bottle after ultraviolet ray sterilization bactericidal.
In described step a, the Herba Taraxaci plucked is cleaned, extraction pot heating extraction is put into 2 times after dry in the sun, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.06 extractum, as component 1; In described step b, the Herba Taraxaci dregs of extraction can be put into together with all the other raw materials described and account for its quality 5-10 times water gaging, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, 2 extracting solution are merged and leaves standstill, reducing pressure and being concentrated into liquor strength is 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.08; Be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, and the extractum of temperature to 60 DEG C-70 DEG C, as component 2.
In described step c, put into concentrating under reduced pressure tank, decompression recycling ethanol after component 1 can being mixed with component 2, being concentrated into liquor strength is 0.1g crude drug/mL, when sucking filtration to the relative density of filtrate is 20 DEG C 1.06; Above-mentioned filtrate, after the macroporous adsorptive resins absorption that volume is 10L, with deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, then be in harmonious proportion Mel, bottle after ultraviolet ray sterilization bactericidal.
Liver and gall diseases is the commonly encountered diseases frequently-occurring disease of serious harm human health, promotes liver cell regeneration at present and prevent hepatic necrosis without specific medicament.The present invention has significant protective effect to the acute liver damage that CCL4 causes, and makes the remarkable reducing effect of SGOT.Serum transaminase raises and mainly reflects hepatocellular degeneration, necrosis, and permeability of cell membrane raises, and GPT, GOT in hepatocyte are released into caused by blood.Having bibliographical information to raise with hepatocyte injury degree by poisoning animal SGPT, the SGOT caused of CCL4 is rough parallel relation.The present invention reduces SGOT effect selectively, and heavy dose makes liver index reduce, and also illustrates that this medicine has good hepatoprotective effect.The present invention shows Herba Taraxaci heat-clearing and toxic substances removing, diuresis eliminating stagnation, for hepatobiliary disease, truly has significant curative effect for low icterus index, the shortening course of disease, mitigation symptoms and recovery liver function.
Detailed description of the invention
The traditional Chinese medical science thinks that hepatitis belongs to damp-heat accumulation more and causes bile to leak to invade and the place such as skin, sclera and yellow cellulitis occurs, and because of the liver failing to maintain the normal flow of QI, dysfunction of the spleen in transportation and the symptom such as inappetence, nausea and vomiting occurs, treatment should be taked the method for " clearing away heat-damp and promoting diuresis, depressed liver-energy dispersing and function of gallbladder promoting ".
We are through the clinical observation of 77 routine acute Jaundice Jaundice application dandelion preparation treatments, tentatively can find out that Herba Taraxaci has certain effect to jaundice eliminating, reduction glutamate pyruvate transaminase, and make in 30 days the acute Jaundice Jaundice patient clinical of 89.6% cure in treatment, be considered to treatment viral hepatitis good medicine on Yunnan and other places, to treat liver and gall curative effect similar to Folium Isatidis.
Pharmacological tests shows, Herba Taraxaci decoct and injection have the effect reducing rat glutamate pyruvate transaminase that carbon tetrachloride causes and raise, and its hepatic injury can be alleviated, have certain choleretic effect, this may be the pharmacological basis that Herba Taraxaci treats acute Jaundice Jaundice.In view of dandelion preparation is to laboratory animal hypophysis cerebri, adrenal gland etc. organize harmless effect, do not find any side effect clinically, and the effect such as medicine source is extensive, has good sterilization, protects the liver, function of gallbladder promoting, be worth its effective ingredient of research further, reform dosage form, expand clinical application range.
Poria sweet in the mouth, light, property are put down, and are used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect.Poria slightly sweet flavor is put down, and enters the heart, lung, spleen channel.There is eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, effect of mind tranquilizing and the heart calming.Can control dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful disease such as grade.The diuretic of Poria, is reached by strong activating the spleen pulmonary function, different from the Chinese medicine of other direct diuretic.For diarrhea due to hypofunction of the spleen, leukorrhagia Poria can spleen invigorating, again can eliminating dampness by diuresis, and for having loose bowels caused by insufficiency of the spleen dysfunction of the spleen in transportation and transformation, leukorrhagia, application Poria has the effect of giving consideration to both the incidental and fundamental, the compatibilities such as normal and Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae.Can be used as tonifying the lung spleen, control the adjuvant of the deficiency of vital energy.
Herba Artemisiae Scopariae clearing away heat-damp and promoting diuresis; Jaundice eliminating.Cure mainly: jaundice, dysuria, eczema pruritus, infectious jaundice type hepatitis.There is function of gallbladder promoting, liver function protecting, antipyretic, antiinflammatory, blood fat reducing, blood pressure lowering, the effects such as coronary dilating. Herba Artemisiae Scopariae has significant hepatoprotective effect, and to first, hepatitis B, icterohepatitis, has significant curative effect.There is function of gallbladder promoting, promote bile secretion, increase the effect that in bile, cholic acid and bilirubin are discharged. heart coronary flow can be increased, improve microcirculation, and have blood pressure lowering, blood fat reducing, anticoagulation, diuresis is antipyretic relievings asthma, and drives away ascarid and suppresses the effect of multiple pathogenic dermatophytes and antibacterial.
Spica Prunellae has the effect of improving eyesight of relieving inflammation or internal heat, and can control conjunctival congestion and swelling pain, headache etc.This product decoct, water-leach liquor, alcohol-water leachate and alcohol leaching liquid all can obviously reduce laboratory animal blood pressure, and stem, leaf, fringe and herb all have hypotensive effect, but the effect of fringe is more obvious; This product water decoction-alcohol sedimentation liquid mouse peritoneal is injected, and has obvious antiinflammatory action; This product decoct all has certain inhibitory action to dysentery bacterium, Bacillus typhi, vibrio cholera, escherichia coli, Bacillus proteus, staphylococcus and Bacillus tuberculosis in vitro.Spica Prunellae compatibility Radix Angelicae Sinensis, Radix Paeoniae Alba Spica Prunellae liver heat removing scattered silt; Radix Angelicae Sinensis, the Radix Paeoniae Alba nourish blood and enrich blood. and three 5 separates stagnation of liver-QI with having, effect of nourishing the liver blood is used for the treatment of all diseases caused by hepatic depression and blood deficiency. Spica Prunellae compatibility Flos Chrysanthemi Spica Prunellae clearing away liver-fire, suppressing the hyperactive liver sun; The cool liver of Flos Chrysanthemi heat clearing away. Papillary have liver heat removing, cool liver, suppressing the hyperactive liver merit is used for the treatment of flaming up of liver-fire, wind-heat of liver channel causes conjunctival congestion and swelling pain; Or the headache, dizzy that excessive rising of liver-YANG causes.
The Radix Paeoniae Alba is bitter, is slightly cold.Return Liver Channel.Attending effectiveness: clearing away heat and cooling blood; Blood circulation promoting and blood stasis dispelling.Main maculae caused by violent heat pathogen; Hematemesis and epistaxis; Discharging fresh blood stool; Conjunctival congestion and swelling pain; Carbuncle skin infection; Amenorrhea; Dysmenorrhea; Metrorrhagia and leukorrhagia stranguria with turbid discharge; The stagnant hypochondriac pain of the stasis of blood; Hernia abdominal mass is gathered; Injury from falling down.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection." herbal classic ": main pathogen stomachache, except arthralgia due to stagnation of blood, broken hard long-pending, cold and heat hernia abdominal mass, pain relieving, diuresis, QI invigorating." not Lu ": clear and coherent blood vessels, in slow, dispelling malignant blood, expelling extravasated blood, anhydrate gas, sharp bladder intestine and small intestine, subduing inflammation, time row cold and heat, attacked by pestiferous factors is suffered from abdominal pain, lumbago." property of medicine opinion ": control pathogen of the lung gas, Fu Zhong Xu pain, vim and vigour are gathered, and logical a surname's internal organs gather around gas, control evil pain deteriorated blood, and disease bone heat time main, strong the five internal organs, the kidney invigorating gas, controls trusted subordinate's heavily fortified point swollen, and married woman's blood closes obstructed, and repercussive blood can lose pus.
Stigma Maydis sweet in the mouth, light, property is put down.There is inducing diuresis to remove edema; Effect of liver heat removing function of gallbladder promoting.Main edema, dribbling urination, jaundice, cholecystitis, cholelithiasis, hypertension, diabetes, galactostasis." the southern regions of the Yunnan Province book on Chinese herbal medicine ": the wide intestinal therapeutic method to keep the adverse QI flowing downwards.Control married woman's breast knot, galactostasis, congestion and swelling pain, heating of being afraid of cold, headache body is stranded." south of the Five Ridges gather medicinal herbs record ": decoct soup with Carnis Sus domestica and control diabetes.Control again dribbling urination sandstone, bitter unbearably painful, decoct soup and be taken in small doses at short intervals.
The micro-hardship of Rhizoma Polygoni Cuspidati, is slightly cold.Return liver, gallbladder, lung meridian.Function with cure mainly heat-clearing and toxic substances removing, promoting the function of the gallbladder to alleviate jaundice, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea, postnatal blood stasis does not Xia , WEIJIA, cough with copious phlegm, burn due to hot liquid or fire, traumatic injury, carbuncle sore tumefacting virus.Huzhang effect, has obvious anastalsis to traumatic hemorrhage, and for oral administration also have anastalsis to upper gastrointestinal hemorrhage." Japan hanako materia medica ": after managing property stagnant blood not under, trusted subordinate's distension.Evacuation of pus, main furuncle carbuncle poison, married woman's bruise, flutters damage blood stasis, broken pathogenic wind toxic stagnation of QI." the southern regions of the Yunnan Province book on Chinese herbal medicine ": attack all toxic swellings, only have sore throat, diuresis, walk meridians.Control five types of stranguria nebulousurine, anal fistula, carbuncle sore, married woman's leucorrhea with red and white discharge.
Herba Ecliptae Compositae, annual herb plant.Uprightly, tool stolon; Leaf to life, lanceolar; Head inflorescence, axil is raw or top is raw, floral white; Achene black.Whole nation dispersed species.Be common in field stalk, Gou Xi limit wetland.Herb is medicinal, can restrain, stop blooding, effect of invigorating the liver and kidney.Nourishing the liver and kidney, cooling blood for hemostasis, can control various haematemesis, the diseases such as enterorrhagia.Smash juice painting eyebrow to send out, can promote hair growth, for oral administration have black hair, hair color effect.Tang Materia Medica is said, Herba Ecliptae " main dysentery, acupuncture skin ulcer is sent out, big vast blood can not the person of stopping respect it " also say in " Japan hanako materia medica ", Herba Ecliptae can " logical small intestinal, applies all skin ulcers and silkworm Guo for evacuation of pus, hemostasis ".
Rhizoma Curcumae rhizome claims " Rhizoma Curcumae ", hyoscine, cures mainly that " lump in the abdomen, gathers, and dyspepsia does not disappear for coagulation of QI-blood, trusted subordinate's distending pain, and women's blood stasis amenorrhea, traumatic injury is had a pain." tuber claims " green filament Radix Curcumae ", has promoting QI circulation for relieving depression, removing blood stasis with potent drugs, the function of pain relieving.Pungent, bitter, temperature.Return liver, spleen channel.Removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.For abdominal pain due to blood stasis, hepatosplenomegaly, trusted subordinate's distending pain, gather, women's blood stasis amenorrhea, traumatic injury is had a pain eating accumulation.Promoting the circulation of QI to relieve pain, removing blood stasis removing food stagnancy: for the amenorrhea of qi depression to blood stasis, chest and hypochondrium, stomachache and lump in the abdomen lump etc.Often join Rhizoma Sparganii.
Radix Bupleuri nature and flavor are bitter, be slightly cold, and return liver, gallbladder meridian.There is reconciling superficies and interior, effect of soothing the liver yang invigorating.For cold, fever, alternate attack of chill and fever, malaria, stagnation of QI due to depression of the liver, sternal rib pain, proctoptosis, uterine prolapse, menoxenia.Reconciling superficies and interior, dispersing the stagnated live-QI to relieve the stagnation of QI, ascending up spleen-Qi and Yang, preventing the attack (or recurrence) of malaria of bringing down a fever." herbal classic is met former ": " all malaria cold and heat, suitablely use it for Radix Bupleuri, the thin heat of children's's five kinds of child malnutrition.Varioliform exanthema is shown in has cold and heat a little, or the lower heat and pain of the side of body, with it in expelling pathogenic factors from the exterior medicine, does not make heat stay in shaoyang channel, then in the future without the trouble grited one's teeth.”
Radix Angelicae Sinensis, its sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, therefore again can promoting the circulation of blood, and invigorating middle warmer has, has benefit, the gas medicine in sincere blood, the panacea also in blood in row.Then mending to mend of about assistant, therefore can nutrition blood be supported, QI invigorating spermatogenesis, settling five organs, strong body, beneficial mind, all tangible deficient diseases, unsuitable without institute.Assistant to attack, lead to, therefore pain relieving constipation of dispelling, relieving rigidity of muscles and joints, controls contracture, paralysis, the card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, help with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, and can fall apart greatly Biao Weire, and show not hold back person, helps with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, therefore for its quiet person when keeping away it, the sliding benefaction of property, stool does not consolidate person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, and cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.
Fructus Schisandrae Chinensis is the dry mature fruit of magnoliaceae schisandra Schisandrachinensis (Turcz.) Baill. or schisandra chinensis SchisandrasphenantheraRehd.etWils..The former practises title " Radix Schisandrae Bicoloris ", and the latter practises title " Fructus Schisandrae Sphenantherae ".Pluck during fruit maturation in autumn, dry or dry after steaming, removing carpopodium and impurity.Tang etc. " Newly Revised Canon of Materia Medica " carry " the sweet acid of five tastes skin and flesh, arduous in core, have saline taste ", therefore have the name of Fructus Schisandrae Chinensis.Fructus Schisandrae Chinensis is divided into two kinds, south, north.Ancient medical book Cheng Ta Chi Zhu, profound and, meeting and, list in the top grade Chinese medicine in Sheng Nong's herbal classic the earliest, the power of energy strengthening by means of tonics, medical value is high, has the effect of building body.
The flat sweet in the mouth of Semen Platycladi, the heart, kidney, large intestine channel.Effect of tool tranquilizing by nourishing the heart, loosening bowel to relieve constipation.Control the diseases such as palpitation with fear, insomnia, seminal emission, night sweat, constipation, energy tranquilizing by nourishing the heart, loosening bowel to relieve constipation.For restlessness of asrhenia type and insomnia, severe palpitation, dryness of the intestine makes the secret disease that Dengs." medicineization justice ": Semen Platycladi, the saturating heart of fragrance, body profit grows blood.Same Poria cum Radix Pini, Semen Ziziphi Spinosae, the Radix Rehmanniae, Radix Ophiopogonis, be product clear in turbid, cure mainly mind void timid, palpitation with fear severe palpitation, color is wan and sallow, skin pruritus due to dryness, and the merit of the blood that all nourishes heart also.Get again abnormal smells from the patient all dense, return kidney in turbid, same to Radix Rehmanniae Preparata, Carapax et Plastrum Testudinis, Fructus Lycii, Radix Achyranthis Bidentatae, be packing bone marrow, cure mainly damage of kidney-YIN, back severe disease, sufficient knee joint is weak, and night sweat due to yin deficiency, the power that all nourishing kidney is dry also.Sweet in the mouth also can delay liver, the deficiency of tonifying liver gallbladder, extremely reliable, but the flat power of property delay, should be multiplex be wonderful.
Chinese medicine Radix Polygoni Multiflori have Radix Polygoni Multiflori and Radix Polygoni Multiflori Preparata point, direct slicing is used as medicine for Radix Polygoni Multiflori, dries be used as medicine for Radix Polygoni Multiflori Preparata with Semen sojae atricolor liquor after mixing steaming.The function of the two is different: the removing toxic substances of Radix Polygoni Multiflori function, eliminating carbuncle, loosening bowel to relieve constipation, is usually used in treatment scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; The invigorating the liver and kidney of Radix Polygoni Multiflori Preparata function, benefiting essence-blood, black beard and hair, bone and muscle strengthening, for blood deficiency and yellow complexion, vertigo and tinnitus, early whitening of beard and hair, soreness of the waist and knees, numb limbs and tense tendons, bleeding not during menses, chronic malaria body void etc.Radix Polygoni Multiflori Preparata of the present invention is the good merchantable brand of invigrating kidney.
Semen Plantaginis this product is sweet in flavor and cold in property, enters kidney, bladder, liver, lung meridian, function relieving stranguria by diuresis, eliminating dampness by diuresis antidiarrheal, liver heat removing and eyesight improving, removing heat-phlegm, is medicinal herbs most in use.Diuretic, heat clearing away, improving eyesight, eliminates the phlegm.Control urinary obstruction, stranguria with turbid discharge, leukorrhagia, hematuria, heat-damp in summer dysentery, cough ant phlegm, arthralgia chiefly caused by damp pathogen, conjunctival congestion is hidden from view." herbal classic ": " main stranguria due to disorder of QI, pain relieving, dredging water passages urine, except arthralgia chiefly caused by damp pathogen." Collective Notes to the Canon of Materia medica: " main asthenia." " not Lu ": " man's damaging the spleen and stomach, woman drenches drop, loss of appetite.Support lung reinforcing YIN-essence benefit essence.Swelling pain is treated in improving eyesight.″
Radix Aucklandiae circulation of qi promoting, pain relieving, spleen invigorating, helps digestion and cures mainly: promoting the circulation of QI to relieve pain; Intestinal stasis relieving in tune.Main born of the same parents coerce distension foot; Abdominal distention; Tell and have loose bowels; Heavy after dysentery.For weighing after breast gastral cavity distending pain, dysentery, food stagnation does not disappear, anorexia; Middle gas is not economized; Sudden deafness; Snake bite and insect sting; Toothache." detailed outline ": the Radix Aucklandiae, is the medicine of three burnt edema caused by disorder of QI, can be elevated all gas.All gas Fen are strongly fragrant, all belong to lung, therefore the person of QI stagnating in upper-JIAO use, be golden Yu Ze let out also; Middle gas is not transported, and all belongs to spleen, therefore the person that QI stagnating in middle-JIAO is suitable, taste happiness fragrance is also; QI stagnation of the large intestine then weighs afterwards, and bladder gas does not change then infirmity pouring, and hepatic depression is then pain, therefore stagnation of QI in lower-JIAO person should it, the person that is plug logical also.
The Radix Rehmanniae: the Radix Rehmanniae is also Radix Rehmanniae, the fresh or dry tuber of Scrophulariaceae herbaceos perennial Radix Rehmanniae RehmanniaglutinosaLibosch..Heat clearing away, promote the production of body fluid, moisturize, laxation, removing blood stasis with potent drugs, tissue regeneration promoting, pain relieving, regulating menstruation, the incised wound stasis of blood, removing heat from blood, hemostasis; The effect of Radix Rehmanniae and Radix Rehmanniae is different.Radix Rehmanniae clearing away heat and promoting production of body fluid, can stop blooding and removing heat from blood, is often for consumption of YIN caused by febrile disease, the diseases such as haematemesis, laryngopharynx swelling and pain, crimson tongue excessive thirst, a speckle dermexanthesis and nosebleed heat.Relative to Radix Rehmanniae, Radix Rehmanniae is heat clearing and blood cooling, also can promote the production of body fluid, all right yin nourishing, is used for treatment yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, crimson tongue excessive thirst, sends out the problems such as speckle dermexanthesis.The Radix Rehmanniae is cold in nature, and function is enriching yin and nourishing kidney.Not only promoting the production of body fluid to quench thirst and heat clearing and blood cooling, also have effect to metrorrhagia, menoxenia, frequent fetal movement, constipation etc., every blood system has the people of thermal burn the moon, can often take.If want to treat epidemic febrile disease, qingying decoction can be done with the Radix Rehmanniae; If the later stage for the treatment of epidemic febrile disease, because waste heat does not also disappear to the greatest extent, the Radix Rehmanniae should be used for boiling QINGHAOBIEJIATANG; In addition, contain for heat in blood poison, macule purple is black, and the serious heat of epidemic febrile disease enters the symptom of nutrient blood, can take the Sisheng Wan that the Radix Rehmanniae is made; General want YIN nourishing and the production of body fluid promoting to treat interior-heat quenches one's thirst with constipation, the once liquid soup that the Radix Rehmanniae boils should be eaten.
Fructus Gardeniae bitter cold, can blood system and clear pathogen is warm, wide intestinal relieving constipation, and give protection against cancer, Flos Gardeniae contains cellulose, can prevent the outbreak of hemorrhoid and the generation of rectum carcinoma.Radix Gardeniae, leaf, fruit all can be used as medicine, and have pathogenic fire purging relieving restlessness, and antiinflammatory is dispelled effect of heat, clearing away heat and promoting diuresis, external removing toxic substances.Flos Gardeniae, fruit, leaf and Gen Ke are used as medicine, and generally make tea or decoct soup clothes.Fructus Gardeniae, containing gardenoside, geniposide, Herba Paederiae time glycoside methyl ester and a small amount of shanzhiside, has the effects such as clearing away heat and promoting diuresis, external removing toxic substances, jaundice, stranguria with blood pain are puckery, the red and swollen pain of order, fire-toxin skin ulcer, blood pressure lowering.Wherein fruit of Fructus Gardeniae is used as medicine, and cures mainly calentura hyperpyrexia, dysphoria and insomnia, and excess-fire is had a toothache, aphtha of the mouth and tongue, and nose is advised, and spits blood, eye conjunctivitis, sore swollen toxin, icteric infectious hepatitis, favism, hematuria; Traumatic hemorrhage, bruise are controlled in external.Root is used as medicine and cures mainly infectious hepatitis, traumatic injury, acute toothache.Compendium of Material Medica claims it, and " improving healthy complexion, it is used by " a thousand pieces of gold wing " face cream." " the southern regions of the Yunnan Province book on Chinese herbal medicine " claim its " purte the white, only cough due to lung-heat, only epistaxis blood, expectorant." meridian distribution of property and flavor: cold in nature, sweet-bitter flavor; Enter lung, Liver Channel.Effect: clearing away lung-heat to relieve cough, external is stopped blooding.Cure mainly cough due to lung-heat, nose, cough up phlegm, the diseases such as toxic swelling.Main component: Flos Gardeniae contains Triterpenoid, Fructus Gardeniae flower acid A, B and son acid.Containing volatile oil, comprise benzyl acetate, linalyl acetate, another containing pigment glycoside, C6H14O6 etc.In addition, also containing carbohydrate, protein, crude fibre and multivitamin.
Herba Andrographis has eliminating inflammation and expelling toxin effect, once multi-infection disease was applied to clinically, comprise trauma infection contamination, furuncle, carbuncle, erysipelas, upper respiratory tract infection, acute and chronic tonsillitis, acute and chronic pharyngitis, acute/chronic bronchitis, acute bacillary dysentery, acute gastroenteritis, urinary tract infection, endometritis, pelvic inflammatory disease, otitis media, periodontitis etc., all have curative effect in various degree.Preparation and usage: existing the sixth of the twelve Earthly Branches makes injection, oral capsule or tablet, consumption must be looked various places and produce the different content of preparation and different.To general inflammation infection, can the decoction of Herba Andrographis Radix Glycyrrhizae 2 ~ 3 money, every day 1 dose; Or tablet (the suitable crude drug in whole 1g of every sheet) takes orally, each 4 ~ 8, every day 3 ~ 4 times.To cutization pyogenic infection wound surface, available Folium Andrographis is ground into powder, makes 1: 4 aqueous solution, leaching gauze external application wound.Ear drop topical application be can be made into suppurative otitis media, simultaneously Tabellae Andrographitis for oral administration.
Herba Rabdosiae Lophanthoidis, Classification system Rabdosiaserra (Maxim.) Hara, Herba Rabdosiae Lophanthoidis is traditional herbal medicine, be commonly called as Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori) etc., there is effect of clearing away heat-damp and promoting diuresis, jaundice eliminating damp eliminating, cool the blood dissipate blood stasis, be used for the treatment of the diseases such as acute icterohepatitis, acute cholecystitis, dysentery, enteritis, traumatic injury stasis of blood pain.The diseases such as Herba Rabdosiae Lophanthoidis has effect of clearing away heat-damp and promoting diuresis, jaundice eliminating damp eliminating, cool the blood dissipate blood stasis, is used for the treatment of acute icterohepatitis, acute cholecystitis, dysentery, enteritis, the difficulty in urination, traumatic injury stasis of blood pain.Herba Rabdosiae Lophanthoidis can not treat chronic hepatitis in fact, if the icteric hepatitis B of samples can do acute treatment with Herba Rabdosiae Lophanthoidis, chronic viral hepatitis B or will arrive regular hospital does and treat targetedly, otherwise likely delay treatment, and then increase the difficulty of curing.Chinese herbal medicine Herba Rabdosiae Lophanthoidis has certain effect to hepatitis, but treatment small three positive effect is but very limited.
Flos Lonicerae, has another name called Radix Ophiopogonis (formal name used at school: Lonicerajaponica)." Flos Lonicerae " one comes from Compendium of Material Medica, owing to opening as white at the beginning of Flos Lonicerae, after transfer yellow to, hence obtain one's name Flos Lonicerae.Medical material Flos Lonicerae is Caprifoliaceae woodbine Radix Ophiopogonis and congener dry flower or is with the flower just opened.Flos Lonicerae is described as the good medicine of heat-clearing and toxic substances removing from ancient times.Its property sweet cold fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, also kind removing summer-heat blood poison, for various febrile disease, as fever of the body, dermexanthesis, sends out the diseases such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, equal Be very effective.
Radix Trichosanthis, Chinese medicine name." book on Chinese herbal medicine justice ": medicine so-called Radix Trichosanthis person wantonly, namely cuts into slices with it with the root that withers, has the name of powder, real without powder.Radix Trichosanthis is the root of cucurbitaceous plant Chinese juniper beach wormwood, is a kind of Chinese medicine, and be clearing away heat-fire class medicine, its concrete effect is clearing away heat-fire, promoting the production of body fluid to quench thirst, and evacuation of pus is subsided a swelling.Cure mainly: control calentura thirsty, quench one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid flaccidity.For treatment diabetes, conventional it and drugs for nourishing yin with the use of, to reach the effect for the treatment of both the principal and secondary aspects of a disease.
The specific embodiment of the invention
Specific embodiment 1:
Pluck new fresh Herba Taraxaci, 1-2 hour in ethanol is soaked, heating extraction 2 times, each 1-2 hour after cleaning dry in the sun, remove supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.06 extractum, heating is concentrated into paste, stand for standby use, becomes component 1.
By all the other crude drug Herba Artemisiae Scopariaes, Herba Rabdosiae Lophanthoidis, Spica Prunellae, Radix Bupleuri, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Stigma Maydis, Rhizoma Imperatae, Rhizoma Polygoni Cuspidati, the Radix Aucklandiae, Fructus Schisandrae Chinensis, Semen Platycladi, Flos Lonicerae, Radix Trichosanthis, Rhizoma Curcumae, Herba Ecliptae, Radix Polygoni Multiflori Preparata, Semen Plantaginis, Fructus Gardeniae, the Radix Rehmanniae, Herba Andrographis, put into 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, supernatant is removed after leaving standstill, then concentrating under reduced pressure tank is put into, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when sucking filtration to the relative density of filtrate is 80 DEG C 1.06 extractum, become component 2.
By component 1 and component 2-in-1 and after insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.36, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Unguentum after concentrated adds dextrin and is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.
Specific embodiment 2:
Pluck new fresh Herba Taraxaci, clean dry in the sun, altogether 5000g, steeped in 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.06 extractum, heating is concentrated into paste, stand for standby use, becomes component 1.
By Herba Artemisiae Scopariae 1500g, Herba Rabdosiae Lophanthoidis 1500g, Spica Prunellae 1500g, Radix Bupleuri 1500g, Radix Paeoniae Alba 1500g, Radix Angelicae Sinensis 1500g, Stigma Maydis 1500g, Rhizoma Imperatae 1500g, Rhizoma Polygoni Cuspidati 1500g, Radix Aucklandiae 1500g, Fructus Schisandrae Chinensis 1500g, Semen Platycladi 1500g, Flos Lonicerae 1500g, Radix Trichosanthis 1500g, Rhizoma Curcumae 1500g, Herba Ecliptae 1500g, Radix Polygoni Multiflori Preparata 1500g, Semen Plantaginis 1500g, Fructus Gardeniae 1500g, Radix Rehmanniae 1500g, Herba Andrographis 1500g, the medicine of all the other crude drug is put into 10 times amount ethanol, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, merge extractive liquid, supernatant is removed after leaving standstill, then concentrating under reduced pressure tank is put into, decompression recycling ethanol, being concentrated into liquor strength is 0.6g crude drug/mL, when sucking filtration to the relative density of filtrate is 20 DEG C 1.06 extractum, become component 2.
By component 1 and component 2-in-1 and after insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.35, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Unguentum after concentrated adds dextrin and is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.
Specific embodiment 3: pluck new fresh Herba Taraxaci, clean dry in the sun, altogether after 4500g, put into extraction pot heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.06 extractum, as component 1, by all the other raw materials described by Herba Artemisiae Scopariae 1100g, Herba Rabdosiae Lophanthoidis 1200g, Spica Prunellae 1200g, Radix Bupleuri 1100g, Radix Paeoniae Alba 1200g, Radix Angelicae Sinensis 1100g, Stigma Maydis 1100g, Rhizoma Imperatae 1200g, Rhizoma Polygoni Cuspidati 1200g, Radix Aucklandiae 1100g, Fructus Schisandrae Chinensis 1200g, Semen Platycladi 1100g, Flos Lonicerae 1200g, Radix Trichosanthis 1200g, Rhizoma Curcumae 1200g, Herba Ecliptae 1100g, Radix Polygoni Multiflori Preparata 1100g, Semen Plantaginis 1100g, Fructus Gardeniae 1100g, Radix Rehmanniae 1100g, Herba Andrographis 1100g, put into 5-10 times of water gaging, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, 2 extracting solution are merged and leaves standstill, decompression recycling ethanol, and to be concentrated into liquor strength be 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.08, be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, and the extractum of temperature to 60 DEG C-70 DEG C, as component 2.The mixing of component 1 component 2 inserted in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.05, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Then the quintessence oil that unguentum after concentrated adds component 1 adds propolis mediation, bottles after ultraviolet ray sterilization bactericidal.
Specific embodiment 4: pluck new fresh Herba Taraxaci, cleans dry in the sun, altogether after 4500g, steep in 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.06 extractum, heating is concentrated into paste, stand for standby use, becomes component 1.By Herba Artemisiae Scopariae 1100g, Herba Rabdosiae Lophanthoidis 1200g, Spica Prunellae 1200g, Radix Bupleuri 1100g, Radix Paeoniae Alba 1200g, Radix Angelicae Sinensis 1100g, Stigma Maydis 1100g, Rhizoma Imperatae 1200g, Rhizoma Polygoni Cuspidati 1200g, Radix Aucklandiae 1100g, Fructus Schisandrae Chinensis 1200g, Semen Platycladi 1100g, Flos Lonicerae 1200g, Radix Trichosanthis 1200g, Rhizoma Curcumae 1200g, Herba Ecliptae 1100g, Radix Polygoni Multiflori Preparata 1100g, Semen Plantaginis 1100g, Fructus Gardeniae 1100g, Radix Rehmanniae 1100g, Herba Andrographis 1100g, after described crude drug being put into pulverizer pulverizing, particulate matter is put into ethanol heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill, the medicinal residues that above-mentioned ethanol extraction is crossed are added 10 times of water gaging heating and refluxing extraction 2 times, each 1 ~ 2 hour, 2 extracting solution are merged and leaves standstill, above-mentioned two kinds of extracting solution are merged, as component 2, when to merge component 1 component 2 concentrating under reduced pressure relative density be 80 DEG C 1.36 filtrate, reclaim ethanol, call in propolis, bottle after ultraviolet sterilization.
Test example 1: acute toxicity test of the present invention
One, test material:
Animal: Kunming mouse, body weight 21-24g, male and female half and half, Shandong University's biology laboratory breeding.Medicine: oral liquid of the present invention (preparing by implementation method 2).
Two, method:
1, LD50 calculates: adopt improvement karber's method, mice is divided into 5 groups at random, often organize 10, male and female half and half, dissolve suppository, are made into Cmax, by the administration of mice maximum permission capacity, institute is followed successively by 18,14.4 to dosage by crude drug amount, 11.5,9.2,7.4 (g.kg-1), in animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml, observes animal dead situation.
2, maximum tolerated dose measures (MTD value): get mice 20, each 10 of male and female.Suppository adding distil water is dissolved, is made into maximum concentration, by the maximum tolerated dose of animal, feed device and can twitch to inject to fill with and be as the criterion.In animal fasting (can't help water) after 18 hours, administration at twice in one day (interval half an hour), each 0.5ml (every ml containing crude drug 0.36g), total dose is 18g crude drug/kg.d, 300 times of quite clinical adult 50Kg body weight consumption.Continuous Observation 7 days after administration.
Three, result of the test:
In LD50 calculates when giving mice with maximum acceptable concentration and maximum permission capacity (18g/Kg.d), have no dead mouse, namely LD50 is not measured, ask maximum tolerated dose only, in 7 day observation period, its appetite of animal, activity, hair color, the mental status etc. are all normal, grow normal, there are no death.Namely select the 300 times of doses being equivalent to clinical dosage, and have no adverse reaction, show that acute toxicity is minimum, MTD > 18g/Kg.d.
Test example 2: acute skin irritation test report of the present invention
1, experiment purpose: detect the present invention to the stimulation/corrosiveness of laboratory animal skin and intensity
2, materials and methods:
2.1. tested material: oral liquid of the present invention (obtaining by embodiment method 2)
2.2. laboratory animal: one grade of large ear white race rabbit, 10, female, body weight 2.1-2.3kg; Thered is provided by Affiliated Hospital of Qingdao University biology department Experimental Animal Center;
2.3. test method:
Its spinal column both sides, back are cut by hair in test by the healthy rabbits selecting skin intact 10 for first 24 hours, the left and right each about 4cm × 4cm of unhairing area.Get tested material 0.2ml during test to be applied on two layers of gauze of 2.5cm × 2.5cm, be applied to skin of unhairing surface, side, oilpaper covers, immobilization with adhesive tape.Opposite side skin is as blank.Close after 4 hours, dismantle, and go residual tested material with warm water cleaning, within 1,24 and 48 hour after removing tested material, observe and smear position dermoreaction, and mark.
3, experimental result: any erythema does not appear in laboratory animal skin, red and swollen, inflammation phenomenon.
4, brief summary: judge according to skin wound repair standards of grading in " disinfection technology standard " (1999), the present invention belongs to nonirritant to animal skin stimulus intensity.
Embodiment 3: long term toxicity test data
1, experimental technique
Random for Cavia porcellus part is become 4 groups, often organizes 15.In guinea pig back spinal column both sides, depilatory is evenly coated, make its scope about 40 square centimeters of losing hair or feathers.Clean depilatory, observe and often organize Cavia porcellus after 24 hours and be coated with oral liquid solution 0.2,0.4 of the present invention and 0.8ml respectively, respectively containing crude drug 92,184 and 368mg, another group is coated with the every twice-daily of solvent 0.8ml, continuous 30 days, observe the ordinary circumstance of Cavia porcellus, experiment terminates rear execution animal and carries out hematology, blood biochemical and pathological examination.
2, result
Above-mentioned three groups of medication Cavia porcellus trunk unhairing districts, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group and control animals chroma of hair, ingest, the matched group no significant difference such as extremity are movable, blood biochemistry checking, medication group and matched group are all in normal range.Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious pathological changes.Prompting, Chinese medicine oral liquid long-term prescription of the present invention is showed no obvious toxic action to local skin and whole body important organ.
Result of the test shows: oral liquid experiment safety of the present invention.This medicine is 1: 150 to group B streptococcus, staphylococcus aureus, colibacillary minimal inhibitory concentration, gonococcus is 1: 150, Candida albicans is 1: 300, it is 5 minutes to the time of killing during 1: 20 dilution factor, be 10 minutes when 1: 50, being 20 minutes when 1: 100, is 40 minutes when 1: 200, is 8 hours when 1: 400.
Pharmacological experiment:
Herba Taraxaci has obvious protective effect to the hepatic injury that normal mouse is caused by carbon tetrachloride, shows as SGOT and significantly reduces, and makes liver body than reducing (heavy dose).Have significant choleretic effect to normal rat, bile flow increases and continues 2h.Ursodesoxycholic acid flow increases and continues 1 hour.Compare between group before bile cholesterol, bilirubin administration and after administration and have no the significance difference opposite sex.We conducted experimentation for this reason.
1, materials and methods
Medicine: Herba Taraxaci of the present invention proposes the preparation of alcohol deposit fluid: get a certain amount of crude drug of the present invention, decocting twice, adds 95 alcohol settling impurity after water-bath being concentrated into certain volume, cross liquid, filtrate recycling ethanol.Be made into 100% concentration.
Matched group is White Cloud Mountain XIAOYAN LIDAN PIAN, the accurate word Z44022243 of traditional Chinese medicines.Ursodesoxycholic acid is that Mitsubishi changes into production.
Animal ICR mice, SD rat provides by zooscopy room, the court.
The protective effect of the mouse liver injury that the 1.1 pairs of carbon tetrachloride cause: male mice 78, body weight 18-23g, is divided into six groups by body weight random stratified, often organizes 13.The present invention 3 dosage group 2.5g/kg, 5.0g/kg, 10.0g/kg, positive control drug White Cloud Mountain XIAOYAN LIDAN PIAN 10g/kg, model group, water matched group gastric infusion every day once, continuous 6d, after administration in the 6th day, 1h dewaters, and all the other respectively organize carbon tetrachloride vegetable oil 5ml/kg of equal subcutaneous injection 0.15 to matched group outward.Pluck eyeball after 16h and get kit measurement serum SGPT, SGOT of producing blood Beijing Chemical Plant.Solution cuts liver and weighs, and calculates the liver body ratio of every mice, data represent with average scholar standard deviation, carry out t inspection between group according to body weight when putting to death.
1.2 affect 1.2.1 to normal rat bile flow
The mensuration of bile flow: get rat 60, male, body weight 250 ~ 350g, weighs and is divided into five groups at random, often organizes 12, and fasting 12h before experiment, can't help water.Experiment is with 10% urethane 1.0g/kg intraperitoneal injection of anesthesia, face upward position and be fixed on operating-table, along abdomen median line open abdomen, find out duodenum, the gallbladder pipe finding white flexible in portion's mesentery is falling, two rhizoid lines are worn under it, ligation pars papillaris, " V " shape otch is made to liver direction, insert plastic conduit, ligation is fixed, namely pistac gallbladder antiperspirant is had to flow out as seen, gallbladder juice collected by test tube, postoperative with saline gauze covering abdominal cavity, after stable 1h, first collect the gallbladder juice of 30min, as the basic value before administration, then to divide into groups administration (through duodenum).The present invention 3 dosage group 2.5g/kg, 5.0g/kg, 10.0g/kg, water matched group, positive drug ursodesoxycholic acid 0.5g/kg.Measurement 1 bile is collected every 30min after administration.4h altogether.
1.2.2 the mensuration of bile component: before administration, the bile that after administration, 4h collects measures bilirubin (health Bioisystech Co., Ltd of Erie produces, caffeine method).The test kit that Determination of Cholesterol Content is produced with Eastern Europe bio-engineering corporation, enzymatic assays.
2 experimental results
The protective effect of the mouse liver injury that the 2.1 pairs of carbon tetrachloride cause: SGPT, SGOT that carbon tetrachloride causes significantly raise P < 0.01, illustrates moulding success.The present invention makes SGOT significantly reduce by three equal P < 0.05 of dosage group, and the present invention has no significant effect SGPT.White Cloud Mountain XIAOYAN LIDAN PIAN makes SGPT, SGOT significantly reduce (P-~ 0.05).Herba Lycopi 10g/kg group makes liver body than significantly lower than carbon tetrachloride model group.Refer to table 1.
Table 1 the present invention is on the impact (X ± S) of carbon tetrachloride poisoning mice serum transaminase
Note: carry out t inspection between group, with carbon tetrachloride group than * P < 0.05, * * P < 0.01
2.2 impacts on normal rat bile flow: 2.5g/kg group of the present invention makes normal rat bile flow increase, continue 2h, increase the most remarkable < 0.05 with the 30min after administration).The each phase of 5.0g/kg group administration 2h all significantly to increase after the administration of < 0.05.10.0g/kg group all remarkable than the matched group rising (P < 0.01, P < 0.05) of each phase in 90min.Positive drug ursodesoxycholic acid also makes flow increase, and continues 1h.P < 0.05 refers to table 2.
Table 2 the present invention is on the impact (X ± S) of anesthetized rat bile flow
Note t with flow before administration for 100%, group is asked and is carried out t inspection, determine bile mesobilirubin with matched group than tiny stream before * P < 0.05, * * P < 0.01. administration of the present invention, after administration and have no significant difference with alcohol content with gallbladder compared with matched group.Refer to table 3.
Table 3 the present invention is on cholesterol, the impact of bilirubin output (X ± S) in rat bile
Discuss:
The traditional Chinese medical science thinks that hepatitis belongs to damp-heat accumulation more and causes bile to leak to invade and the place such as skin, sclera and yellow cellulitis occurs, and because of the liver failing to maintain the normal flow of QI, dysfunction of the spleen in transportation and the symptom such as inappetence, nausea and vomiting occurs, treatment should be taked the method for " clearing away heat-damp and promoting diuresis, depressed liver-energy dispersing and function of gallbladder promoting ".
We are through the clinical observation of 77 routine acute Jaundice Jaundice application dandelion preparation treatments, tentatively can find out that Herba Taraxaci has certain effect to jaundice eliminating, reduction glutamate pyruvate transaminase, and make in 30 days the acute Jaundice Jaundice patient clinical of 89.6% cure in treatment, be considered to treatment viral hepatitis good medicine on Yunnan and other places, to treat liver and gall curative effect similar to Folium Isatidis.
Pharmacological tests shows, Herba Taraxaci decoct and injection have the effect reducing rat glutamate pyruvate transaminase that carbon tetrachloride causes and raise, and its hepatic injury can be alleviated, have certain choleretic effect, this may be the pharmacological basis that Herba Taraxaci treats acute Jaundice Jaundice.In view of dandelion preparation is to laboratory animal hypophysis cerebri, adrenal gland etc. organize harmless effect, do not find any side effect clinically, and the effect such as medicine source is extensive, has good sterilization, protects the liver, function of gallbladder promoting, be worth its effective ingredient of research further, reform dosage form, expand clinical application range.
Liver and gall diseases is the commonly encountered diseases frequently-occurring disease of serious harm human health, promotes liver cell regeneration at present and prevent hepatic necrosis without specific medicament.Our experiment has proved that the present invention has the effect of good anti-experimental character hepatitis interstitialis chronica.This experiment shows that the present invention has significant protective effect to the acute liver damage that CCL4 causes, and makes the remarkable reducing effect of SGOT.Serum transaminase raises and mainly reflects hepatocellular degeneration, necrosis, and permeability of cell membrane raises, and GPT, GOT in hepatocyte are released into caused by blood.Having bibliographical information to raise with hepatocyte injury degree by poisoning animal SGPT, the SGOT caused of CCL4 is rough parallel relation.The present invention reduces SGOT effect selectively, and heavy dose makes liver index reduce, and also illustrates that this medicine has good hepatoprotective effect.

Claims (10)

1. the Herba Taraxaci oral liquid of a hepatic cholagogic, it is characterized in that, described oral liquid comprises the crude drug of following parts by weight: Herba Taraxaci 10 ~ 50 parts, Herba Artemisiae Scopariae 10 ~ 20 parts, Herba Rabdosiae Lophanthoidis 10 ~ 20 parts, Spica Prunellae 10 ~ 20 parts, Radix Bupleuri 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Stigma Maydis 10 ~ 20 parts, Rhizoma Imperatae 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, the Radix Aucklandiae 10 ~ 20 parts, Fructus Schisandrae Chinensis 10 ~ 20 parts, Semen Platycladi 10 ~ 20 parts, Flos Lonicerae 10 ~ 20 parts, Radix Trichosanthis 10 ~ 20 parts, Rhizoma Curcumae 10 ~ 20 parts, Herba Ecliptae 10 ~ 20 parts, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, Semen Plantaginis 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, 10 ~ 20 parts, the Radix Rehmanniae, Herba Andrographis 10 ~ 20 parts.
2. the Herba Taraxaci oral liquid of hepatic cholagogic according to claim 1, it is characterized in that, in described oral liquid, the parts by weight of various crude drug are: Herba Taraxaci 10 ~ 40 parts, Herba Artemisiae Scopariae 10 ~ 15 parts, Herba Rabdosiae Lophanthoidis 10 ~ 15 parts, Spica Prunellae 10 ~ 15 parts, Radix Bupleuri 10 ~ 15 parts, the Radix Paeoniae Alba 10 ~ 15 parts, Radix Angelicae Sinensis 10 ~ 15 parts, Stigma Maydis 10 ~ 15 parts, Rhizoma Imperatae 10 ~ 15 parts, Rhizoma Polygoni Cuspidati 10 ~ 15 parts, the Radix Aucklandiae 10 ~ 15 parts, Fructus Schisandrae Chinensis 10 ~ 20 parts, Semen Platycladi 10 ~ 20 parts, Flos Lonicerae 10 ~ 20 parts, Radix Trichosanthis 10 ~ 20 parts, Rhizoma Curcumae 10 ~ 20 parts, Herba Ecliptae 10 ~ 20 parts, Radix Polygoni Multiflori Preparata 10 ~ 20 parts, Semen Plantaginis 10 ~ 20 parts, Fructus Gardeniae 10 ~ 20 parts, 10 ~ 20 parts, the Radix Rehmanniae, Herba Andrographis 10 ~ 20 parts.
3. the Herba Taraxaci oral liquid of hepatic cholagogic according to claim 1, it is characterized in that, in described oral liquid, the parts by weight of various crude drug are: Herba Taraxaci 10 ~ 30 parts, Herba Artemisiae Scopariae 10 ~ 20 parts, Herba Rabdosiae Lophanthoidis 10 ~ 20 parts, Spica Prunellae 10 ~ 20 parts, Radix Bupleuri 10 ~ 20 parts, the Radix Paeoniae Alba 10 ~ 20 parts, Radix Angelicae Sinensis 10 ~ 20 parts, Stigma Maydis 10 ~ 20 parts, Rhizoma Imperatae 10 ~ 20 parts, Rhizoma Polygoni Cuspidati 10 ~ 20 parts, the Radix Aucklandiae 10 ~ 20 parts, Fructus Schisandrae Chinensis 10 ~ 15 parts, Semen Platycladi 10 ~ 15 parts, Flos Lonicerae 10 ~ 15 parts, Radix Trichosanthis 10 ~ 15 parts, Rhizoma Curcumae 10 ~ 15 parts, Herba Ecliptae 10 ~ 15 parts, Radix Polygoni Multiflori Preparata 10 ~ 15 parts, Semen Plantaginis 10 ~ 15 parts, Fructus Gardeniae 10 ~ 15 parts, 10 ~ 15 parts, the Radix Rehmanniae, Herba Andrographis 10 ~ 15 parts.
4. the preparation method of the Herba Taraxaci oral liquid of hepatic cholagogic according to any one of claims 1 to 3, it is characterized in that, the preparation process of described oral liquid comprises:
A. the preparation of Herba Taraxaci, as component 1;
B. all the other crude drug described are put into ethanol heating and refluxing extraction 2 times, as component 2;
C. by above-mentioned two kinds of extracting solution components 1 and component also 2-in-1, add Mel after concentrated or dextrin is in harmonious proportion, after disinfection, be prepared into oral liquid bottling.
5. the preparation method of the Herba Taraxaci oral liquid of hepatic cholagogic according to claim 4, it is characterized in that, in described step a, pluck Herba Taraxaci, after clean dry, soaked 1-2 hour in the ethanol accounting for its quality 10 times amount, then put into extraction pot heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.06 extractum, heating is concentrated into paste, stand for standby use, becomes component 1 for subsequent use.
6. the preparation method of the Herba Taraxaci oral liquid of hepatic cholagogic according to claim 4, is characterized in that, in described step b, all the other raw materials described are steeped and accounts in its quality 10 times amount ethanol, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.06 extractum, heating is concentrated into paste, stand for standby use, becomes component 2.
7. the preparation method of the Herba Taraxaci oral liquid of hepatic cholagogic according to claim 4, is characterized in that, in described step c, by component 1 and component 2-in-1 and after, insert in economic benefits and social benefits vacuum concentrator, when being concentrated into 90 DEG C, relative density is the concentrated solution of 1.36, sets to 0 ~ 5 DEG C of deepfreezes 24 hours; Cold preservation liquid is added the filter aid kieselguhr of 0.3%, filter, filtrate is inserted in economic benefits and social benefits vacuum concentrator again, is concentrated into every 1ml containing 0.1g crude drug amount; Unguentum after concentrated adds Mel or dextrin is in harmonious proportion, and bottles after ultraviolet ray sterilization bactericidal.
8. the preparation method of the Herba Taraxaci oral liquid of hepatic cholagogic according to any one of claims 1 to 3, it is characterized in that, preparation process can also be:
A. by Herba Taraxaci extracting in water, as component 1;
B. Herba Taraxaci is extracted rear residue to soak together with all the other crude drug described, extract 2 times as component 2;
C. component 1, component 2 are mixed concentrated after add Mel and be in harmonious proportion, bottle after ultraviolet ray sterilization bactericidal.
9. the preparation method of the Herba Taraxaci oral liquid of hepatic cholagogic according to claim 8, it is characterized in that, in described step a, the Herba Taraxaci plucked is cleaned, extraction pot heating extraction is put into 2 times after dry in the sun, each 1-2 hour, removes supernatant, merge extractive liquid, 100-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.06 extractum, as component 1; In described step b, the Herba Taraxaci dregs of extraction are put into together with all the other raw materials described and accounts for its quality 5-10 times water gaging, soak 1-2 hour, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 100-120 order filters, 2 extracting solution are merged and leaves standstill, reducing pressure and being concentrated into liquor strength is 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.08; Be decompressed to 0.03-0.08MPa, temperature remains on 60-80 DEG C, and being concentrated into relative density is 1.20, and the extractum of temperature to 60 DEG C-70 DEG C, as component 2.
10. the preparation method of the Herba Taraxaci oral liquid of hepatic cholagogic according to claim 8, it is characterized in that, in described step c, concentrating under reduced pressure tank is put into after component 1 being mixed with component 2, decompression recycling ethanol, being concentrated into liquor strength is 0.1g crude drug/mL, when sucking filtration to the relative density of filtrate is 20 DEG C 1.06; Above-mentioned filtrate, after the macroporous adsorptive resins absorption that volume is 10L, with deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collect ethanol elution, remove solvent, then be in harmonious proportion Mel, bottle after ultraviolet ray sterilization bactericidal.
CN201510658350.1A 2015-10-12 2015-10-12 Dandelion oral liquid capable of protecting liver and benefiting gallbladder and preparation method thereof Pending CN105169278A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106214997A (en) * 2016-08-02 2016-12-14 马佳 A kind of Herba Taraxaci oral liquid of Elmination of toxicant and fat-lowering fat-reducing and preparation method thereof
CN106237131A (en) * 2016-08-02 2016-12-21 马佳 The Herba Taraxaci oral liquor of lowering blood-fat and reducing weight and oral liquid thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101104069A (en) * 2007-06-14 2008-01-16 王寿叶 Traditional Chinese medicine formula for treating liver (biliary) inflammation
CN102349990A (en) * 2011-10-18 2012-02-15 董洪海 Traditional Chinese medicine for treating hepatitis B

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101104069A (en) * 2007-06-14 2008-01-16 王寿叶 Traditional Chinese medicine formula for treating liver (biliary) inflammation
CN102349990A (en) * 2011-10-18 2012-02-15 董洪海 Traditional Chinese medicine for treating hepatitis B

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106214997A (en) * 2016-08-02 2016-12-14 马佳 A kind of Herba Taraxaci oral liquid of Elmination of toxicant and fat-lowering fat-reducing and preparation method thereof
CN106237131A (en) * 2016-08-02 2016-12-21 马佳 The Herba Taraxaci oral liquor of lowering blood-fat and reducing weight and oral liquid thereof

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