CN102091300A - Granule for protecting liver and relieving depression - Google Patents
Granule for protecting liver and relieving depression Download PDFInfo
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Abstract
The invention provides granule for protecting the liver and relieving depression, prepared from the following raw materials in parts by weight: 6-15 of radix curcumae, 6-15 of white peony root, 6-15 of self-heal and 2-5 of dried orange peel. The granule is prepared by the following steps: a, cleaning the radix curcumae, the self-heal and the dried orange peel, adding water to just submerse the crude medicines, soaking, then decocting, filtering to obtain the filtrate, adding water to the filter residue to just submerse the filter residue, then decocting again and filtering to obtain the filtrate; b, cleaning the white peony root, adding water to just submerse the white peony root, soaking, then decocting, filtering to obtain the filtrate, adding water to the filter residue to just submerse the filter residue, then decocting again and filtering to obtain the filtrate and the filter residue for later use; c, combining the filtrates obtained in the step a and the step b, concentrating the filtrate into cream; d, adding ethanol to the filter residue obtained in the step b to just submerse the filter residue, soaking, extracting by reflux to obtain ethanol extracted filtrate, then concentrating into cream; and e, combining the creams obtained in the step c and the step d, then adding dextrin and ethanol to form dough balls, and finally, granulating, drying and packaging to obtain the product.
Description
Technical field:
The present invention relates to the health care of food technical field, further say to relate to a kind of hepatoprotective resolving depression granule.
Background technology:
China has been hepatopathy big country, and diseases such as fatty liver, alcoholic liver, viral hepatitis, medicamentous liver lesion are soaring year by year.About 1,200,000 examples of the annual acute virus type incidence of hepatitis of China; Existing about 1,200 ten thousand examples of chronic hepatitis patient, the ill colony of hepatitis B is 1.2 hundred million people.Annual about 300,000 examples because of hepatopathy death.Liver-protecting medicine and Remed for hepatopathy market have been expedited the emergence of by huge patient colony.The annual hepatoprotective of China, treating the liver medicine and liver surgery medical expense are costly.
At present, Chinese society is in the economic transition phase again, and rhythm of life is accelerated, and study and work pressure increases, and adds that under the background of global financial crisis, multiple factor causes people's mental maladjustment, and psychology is constrained, even depressed, irritability, and excessive drinking, immune function of human body is low.The Shandong evening paper A22 version report on May 4th, 2010, excessive anger impairing the liver, wine impairing the liver, Chinese society's male's hepatopathy in the future must be the first.
Liver depression and qi stagnation is meant because the catharsis dysfunction of liver, catharsis not as good as and cause the card marquis that depression and stagnation of QI shows, claim syndrome of stagnation of liver qi again.Stagnation of QI due to depression of the liver is that various hepatopathys form the initial seed of trouble, develops into various hepatopathys thereafter.In hepatopathy, the stagnation of QI due to depression of the liver patient is first place wherein.In these years, the stagnation of QI due to depression of the liver patient is more and more, and wherein 17 to 50 years old people is the main colony of this disease.
Summary of the invention:
The objective of the invention is at the stagnation of QI due to depression of the liver patient who is on the increase in the present society, provide a kind of prescription flavour of a drug few, processing technology is simple, the hepatoprotective resolving depression granule that cost is low.
Purpose of the present invention can realize by following technical measures:
It is to adopt following raw materials in weight portion and step preparation:
Radix Curcumae 6-15 Radix Paeoniae Alba 6-15 Spica Prunellae 6-15 Pericarpium Citri Reticulatae 2-5;
A. get to add water to just after Radix Curcumae, Spica Prunellae, Pericarpium Citri Reticulatae are cleaned and flood, soak 1-1.5h, decocting boils to boiling and keeping boiling 15-30 minute then, the 60-100 order filters, get filtrate, filtering residue adds water to just and floods, and then decocting boils to boiling and keeping boiling 10-25 minute, the 60-100 order filters, and gets filtrate;
B. get to add water to just after the Radix Paeoniae Alba is cleaned and flood, soak 1-1.5h, decocting boils to boiling and keeping boiling 15-30 minute then, and the 60-100 order filters, get filtrate, filtering residue adds water to just and floods, and then decocting boils to boiling and keeping boiling 10-25 minute, the 60-100 order filters, and gets filtrate and filtering residue, and is standby;
C. a step and b step filtrate are merged, be concentrated into paste;
D. get b step filtering residue add weight concentration be 50-70% ethanol to just flooding, soak 0.5-1.5h, reflux, extract, 20-40 minute, the 60-100 order filter alcohol extraction filtrate, steam and remove ethanol and be concentrated into paste;
E. c step and d step paste are merged, according to paste: dextrin: weight concentration 90-97% ethanol=1: 0.2-0.4: 0.08-0.12 weight portion proportioning adds dextrin and ethanol is made dough, after pelletize, drying, packing, product.
Purpose of the present invention also can realize by following technical measures:
Described drying is 70-80 ℃ of vacuum drying 1-1.5h.
In raw material:
Spica Prunellae: be the Labiatae fruit ear of herbaceous plant Spica Prunellae Prunella vulgaris L. for many years.
The Radix Paeoniae Alba: be the root of Ranunculaceae herbaceos perennial Radix Paeoniae Paeonia lactiflora Pall.
Pericarpium Citri Reticulatae: be the mature peel of the evergreen dungarunga plant of Rutaceae Fructus Citri tangerinae Citrus reticulata Blanco and variety thereof.
Radix Curcumae: be Zingiberaceae herbaceos perennial RADIX CURCUMAE Curcuma wenyujinY.H.Chen et C.ling, Rhizoma Curcumae Longae C.Longa L. Guangxi zedoary, the tuber of C.kwang siensis S.G.Lee etC.F.Liang or Rhizoma Curcumae C.phaeocaulis Val..
The pharmacological action general introduction:
Spica Prunellae: bitter, hot, cold.Return liver, gallbladder meridian.Clearing away liver-fire, Disperse hepatic depression.
This product bitter cold, function are let out liver-fire clearly, swollen clearly pain relieving, and liver-fire gets clearly again, and is flourish on the then cloudy blood, so the effect of nourishing the liver to improve visual acuity of holding concurrently.
This product suffering is with eliminating stagnation, and bitter the master goes into Liver Channel to let out clearly, and the effect of good liver heat removing eliminating stagnation is arranged.Be used for pathogenic fire derived from stagnation of liver-QI, the phlegm-fire cohesion is tied in neck, and is caused the scrofula disease, diseases such as goiter.The liver-fire effect of letting out clearly of this product in addition, the modern times are usually used in hypertension and belong to liver-heat, and the card person of yang hyperactivity has the effect of removing heat from the liver to lower the high blood pressure." Amplification on Materia Medica addendum ": " taking a tonic or nourishing food to build up one's health blood vessels "." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " liver-wind of dispelling, the network of passing through.The row irritability is opened stagnation of liver-QI ".Stone stupid " meeting former ": " be good at leading off strongly fragrant the stopping up of liver and gall wood fire, and the operation of QI and blood smoothly ".
This product contains triterpenoid saponin, and glycoside unit mainly is an oleanolic acid, and other contains caffeic acid, alkaloid and water soluble salt
Its decoct has the liver heat removing eliminating stagnation, outside blood pressure lowering and the antiarrhythmic effect, can also inhibitory action be arranged to many pathogenic bacterium, and excited uterus of energy and enhancing enterokinesia have inhibitory action to ehrlich carcinoma and sarcoma 180, and employing water carries or the decocting extracting method is good.Can prepare above functional component complete.
Radix Curcumae: hot, bitter, cold.Return liver, gallbladder, heart channel.The blood-activating and qi-promoting pain relieving is arranged, and resolving depression clears away heart-fire, promoting the function of the gallbladder to alleviate jaundice, removing heat from blood.This product acrid in the mouth can loose and can manage it, and can invigorate blood circulation, again can promoting QI circulation for relieving depression and reach the effect of pain relieving.The hot hardship of loosing of this product is let out, and can have one's ideas straightened out by resolving depression, and it is cold in nature, has the merit that clears away heart-fire concurrently.This product is cold in nature goes into the liver and gall warp, can the clearing heat secreting bile jaundice eliminating, and this product toil and cold in nature can pleasant pathogenic fire reducing and cooling blood for hemostasis.
This product is effective to calculosis, warm type, qi stagnation and blood stasis type etc.
" Bencao Jingshu ": " Radix Curcumae originally goes into the gas medicine of blood system, and it controls above all blood disorder persons, is just calling row on the blood, showing tremendous enthusiasm inflammation in all belonging to, and this medicine can sending down the abnormal ascending QI, and gas falls ... the not absurd row of blood then." essentials of Matea Medica: " circulation of qi promoting, resolving depression are let out blood, removing blood stasis with potent drugs.Cool heat in the heart, the stagnation of liver-QI of loosing is controlled married woman's passages through which vital energy circulates and is driven in the wrong direction ".
" Chinese medicine voluminous dictionary ": " promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs ".
" Amplification on Materia Medica addendum ": " controlling strongly fragrant holding back can not loose ".
This product contains volatile oil, curcumin, fatty wet goods.Its water logging ethanol extract has the effect that alleviates hyperlipidemia, and can obviously prevent the formation of tame rabbit aorta, coronary artery and branch inner membrance speckle thereof.Can promote bile secretion and drainage, and can suppress to be present in the most of microorganism in the gallbladder, analgesic activity is arranged.Curcumin has protective effect to hepar damnification, can obviously expand Mus mesenteric microvessels and arteriovenous, and influence immunologic function, and performance has antiinflammatory action.The employing decocting is carried, and can make above functional component preparation fully.
Pericarpium Citri Reticulatae: hot, bitter, warm, return spleen, lung meridian.
The hot row temperature of this product is logical, and promoting the circulation of QI to relieve pain are arranged, spleen invigorating and in merit.
Ni Zhumo " book on Chinese herbal medicine converge with speech ": " Pericarpium Citri Reticulatae is total to belong to the treasure who regulates the flow of vital energy, if cholera vomiting gas contrary also; Trembling with fear also of the diarrhea accompanied with flatus of having loose bowels; Closing also of obstruction and rejection fullness in the epigastrium and abdomen gas; Stagnating also of food stagnation sputum gas; Winning also of wind and cold administration dampness; The knot of the strongly fragrant gas of seven emotions; The Pericarpium Citri Reticulatae system can be controlled it.The lid acrid in the mouth is kind to loose, so can open gas, bitter in the mouth is apt to let out, so can manage it expectorant; Its temperature is flat, is good at leading to.”
Pericarpium Citri Reticulatae contains volatile oil, flavonoid glycoside (as hesperidin), nobiletin and V
B, V
CDeng.Mostly be water decoction, carry to good with water.Its hesperidin has the effect of Citrin sample, can fall capillary permeability, anti-blood capillary hemostasis; The vascular permeability that energy antagonism histamine and hemolytic phospholipid cause increases, the proteic dissolving of energy fortifying fibre, and antithrombotic forms, and choleretic effect is arranged.
The Radix Paeoniae Alba: bitter, sour, sweet, be slightly cold, return liver, spleen channel
Be used for deficiecny of liver-YIN, disease such as the high partially headache of depression of liver-QI or liver-yin, dizzy, pain over the hypochondriac region.Nourishing liver-YIN is arranged, transfer irritability, suppressing the hyperactive liver sun, the effect of relieving spasm to stop pain.Essentials of Matea Medica: " enrich blood, eliminating pathogen in the liver, strengthening the spleen is held back liver-yin.”
" the southern regions of the Yunnan Province book on Chinese herbal medicine ": " purgation of spleen excess heat is ended stomachache, and sealing rushes down, and it is painful to receive adverse flow of liver-QI, takes good care of conscience spleen channel blood, relaxes through sending down the abnormal ascending QI, ends irritability pain." Huang Yuan drives " beautiful Chinese catalpa medicine is separated ": " Radix Paeoniae acid is trembled with fear into liver, and specially fresh breeze is dry and hold back catharsis.So kind disease of controlling the cloudy wooden Yu Fengdong that faints." the same gas of liver and gall the exterior and the interior, following fresh breeze wood, supernatant is fire mutually, and prompt the effect arranged.
This product contains paeoniflorin, hydroxypaeoniflorin, peony lactone glycoside, benzoylpaeoniflorin and benzoic acid, tannin, volatile oil, fatty oil, resin, sugar, phlegmatic temperament, protein, B-sitosterol, calcium oxalate peonine, paeonol and triterpenoid compound etc.Contained paeoniflorin has spasmolysis preferably.And effects such as certain calmness, analgesia, anti-frightened fault, blood pressure lowering, blood vessel dilating are arranged.
White peony root's total glycoside is replied mouse immune has regulating action; The effect that strengthens the myocardial nutrition blood flow is arranged, and Radix Paeoniae Alba decoct has inhibitory action to some antibacterial, pathogenic bacterium.
The ethanol extract of the Radix Paeoniae Alba can resist flavacin B
1Due to rat blood serum lactic acid dehydrogenase and isozyme LDH
5The rising of level.White peony root's total glycoside 40～80mg/kgip has antagonism to mice plasma glutamate pyruvate transaminase and the lactic acid dehydrogenase rising due to the carbon tetrachloride, and also there is certain protective role in Histological change to the hepatopathy reason.
By monarch, minister, help, make the principles of formulating prescriptions to analyze prescription compatibility of medicines
The Radix Curcumae acrid in the mouth, hardship, cold, go into the conscience gallbladder meridian, have the merit of diffusing stagnation of liver-QI, circulation of qi promoting.Gu have control strongly fragrant hold back can not the person of liter Radix Curcumae also say that property lightly floats though it does not have perfume (or spice), can cause to reach fume in farsighted we's monarch drug.The Spica Prunellae clearing away liver-fire, Disperse hepatic depression, scrofula disease have the merit of taking a tonic or nourishing food to build up one's health the cloudy blood vessels of fainting, and use Disperse hepatic depression together with Radix Curcumae, make light of one's life by commiting suicide, and effect is better, is we's ministerial drug.Radix Paeoniae Alba bitter in the mouth, acid, be slightly cold, return the liver spleen channel.Suppressing liver-YANG, the yin fluid astringing that nourishes blood, intrinsic peace spleen channel is received gastric qi, and blood vessels, and the merit of fixing striae is we's adjuvant drug.Pericarpium Citri Reticulatae is returned the spleen lung meridian, seasoning, and circulation of qi promoting, spleen invigorating fortune is messenger drug.Take a broad view of full side, the eliminating pathogen in the liver spleen reinforcing, invigorating middle warmer residence is dredged, harmonizing the functional activities of vital QI, amount to thin, diffusing, mend, row and, blood is transported, body is light, bone is strong effect.
Function cures mainly:
Circulation of qi promoting, resolving depression, spleen invigorating, stomach reinforcing is used for the stagnation of QI due to depression of the liver of various nervous psychology due to pressure, vexed, insomnia, irritability, fatigue, myasthenia of limbs, constipation with dry stool.
The effectiveness of zoopery checking hepatoprotective resolving depression granular recipe:
The tradition traditional Chinese medical science is thought " excessive anger impairing the liver ", and " element asks YIN YANG classification of natural phenomena big opinion " said: " violent anger impairing YIN ", " impairment of YIN " they are the cloudy blood of impairing the liver, " The liver and the kidney have a common source " again, and the moon that then must be impairment of the kidney for a long time, and cause the hepatic and renal YIN deficiency.Segmentation is analysed it, liver controlling conveyance and dispersion, and the catharsis malfunction of liver, catharsis is too late first, shows as the irritability liter and sends out unable, and gas is capable not smooth, causes " stagnation of QI ", " stagnation of liver-QI " etc., and disease opinion is in a very depressed state, and function is on the low side; Second catharsis too, it is too excited that the liter of liver is sent out impulsion, causes contrary unrest of mechanism of qi or perverse and unreasonable manner, shows as being irritable and getting angry easily, function is high relatively partially.This experiment employing enrages legal system and is equipped with the stagnation of liver-QI model, to detect the effectiveness of this prescription and preparation method thereof.
Wistar male rat 300 ± 20g, per 7 is one group, establishes model group, matched group and drug study group.Check behavioristics's index (fecal grains) and blood plasma 6-ketone-prostaglandin F la (6-Reto-PGFla) and thromboxance B (TXB
2) variation.
Model group:,, make itself and other rat beat up with the most advanced and sophisticated hemostasis clamp Mus tail of gauze parcel with 7 same cages of rat, enrage the rat of full cage, stimulated 30 minutes at every turn, stimulate 1 time every 3h, stimulate every day 4 times, enraging stimulates the observation of carrying out every index after 2 days.
Matched group: 7 rats do not give any stimulation with cage.
Experimental group:
The same model group of stimulating method stimulates 4 every day, 2 administrations, each 0.15g hepatoprotective resolving depression granule, the quite dosage of taking medicine every day 1.Gastric infusion before the 0.5h of Ci Jiing stimulates the 1st and the 2nd time then first; 0.5h gastric infusion once more before stimulating for the 3rd time, carry out then the 3rd and the 4th stimulate.Therapy lasted 2 days.Model group and matched group are irritated the commensurability water of stomach.
Hepatoprotective resolving depression granule is to the experimental result of rat stagnation of liver-QI model
Experimental result shows that model group is compared with matched group, and fecal grains increases, and significant difference shows the modeling success.Medicine group fecal grains is lower than model group, has shown the effectiveness of this medicine.Blood plasma 6-ketone-prostaglandin F la is higher than model group, is lower than matched group, and thromboxance B is lower than model group, is higher than the effectiveness that matched group has also shown modeling success and this medicine.
Clinical practice:
Case is selected: selected patient comes the hospital admission personnel for colleges and universities and middle school student, the personnel of government bodies, enterprise's commerce and trade, suburbs, urban district.Belong to differential diagnosis in tcm stagnation of QI due to depression of the liver patient through going to a doctor.Pill taker 62 people, first week back continuation prescription on individual diagnosis person, 49 people take medicine.17-26 year 14 people wherein, 27-36 year 16 people, 37-46 year 10 people, 47-56 year 6 people, 57-66 year 3 people, male 35 people wherein, women 14 people.Second week back interviewee 30 people take medicine.
Administrated method: this medicine is a granule, (medicine) being taken before meal with or one after each meal the best, can be early, evening each once, once obey a bag (6g/ bag); Also can 1 time/day, 1 bag/time, the 12g/ bag.
Diagnostic criteria: vexed, irritability, insomnia, fatigue, myasthenia of limbs, costalgia; Constipation with dry stool, red tongue, yellow fur, complexion are secretly coarse, stringy pulse.
Criterion of therapeutical effect: 1. produce effects: spirit takes a turn for the better, even-tempered and good-humoured; Sleep is normal; Costalgia alleviates, the extremity sensation is strong; Stool is normal, light red tongue, thin fur, normal pulse and, complexion is normal.
2. effective: take a turn for the better to some extent with respect to spirit before the diagnosis, insomnia slows down to some extent, and extremity are strong than before, and it is still not too unobstructed to defecate, but makes moderate progress light red tongue, yellow and thin fur, wiry and frequent pulse.
3. invalid: spirit, mood, sleep improve not obvious, and costalgia, myasthenia of limbs, constipation with dry stool are still more obvious, red tongue, yellow fur, stringy pulse.
Observe and the result:
It is that to come the patient at random be the stagnation of QI due to depression of the liver patient through differential diagnosis in tcm that case is selected, and to the patient state of an illness and method of administration is described.Every patient's amount of getting it filled is the dose in 1 week, to the prescription on individual diagnosis patient who returns once more after the week of taking medicine, diagnose and estimate according to diagnostic criteria and criterion of therapeutical effect, as the patient take medicine one week the back curative effect statistical data.To being ready to continue the pill taker, give the dose in a week again, to returning the patient of prescription on individual diagnosis after 2 weeks of taking medicine once more, or the doctor askes the patient who visits in person to the doorstep, diagnoses, estimates as the patient and take statistical data after 2 weeks according to diagnostic criteria and criterion of therapeutical effect.Its statistical result is as follows:
The patient took medicine after a week, and 17 years old-66 years old patient divides five groups of totally 49 people, and wherein 14 philtrums in 17-26 year have 1 people invalid, and 16 philtrums in 27-36 year have 2 people invalid, and 10 philtrums in 37-46 year have 1 people invalid, and 4 people are invalid in three age group.Other patients are produce effects 15 people, effective 30 people, and total effective rate is 91.84.These group patients continue to take medicine and ask visit to the 2nd weekend and count on 30 people altogether, wherein organize 8 people in 17-36 year, organize in 27-36 year and organize 5 people in 12 people (wherein have people invalid) 37-46 year, organize 4 people in 47-56 year, organize 1 people in 57-66 year.Produce effects 26 people, effective 3 people, totally 29 people, total effective rate is 96.6%.
Model case:
The river * *, man, 45 years old, because of the big normal phase drink of operating pressure spills, irregular eating occurs vexed, uncomfortable in chest, irritability, poor sleep, extremity fatigue and weak, time sense have expectorant, red tongue, yellow fur, stringy pulse begins to take hepatoprotective resolving depression granule, after serveing on a week, patient's symptom is clearly better, and continues to take first quarter moon to consolidate curative effect.
Lee * *, woman, 48 years old, because of long-term angry, mood does not freely cause vexed, irritability, the both sides of the chest distending pain, it is not good enough to sleep, and time sense has expectorant, menstrual period are irregular, constipation with dry stool, red tongue, yellow fur, stringy pulse begins to take hepatoprotective resolving depression granule one all backs symptom and obviously alleviates, spirit also take a favorable turn, and continues to take first quarter moon to consolidate curative effect.
The specific embodiment:
Embodiment 1:
A. take by weighing Radix Curcumae 15g, Spica Prunellae 15g, Pericarpium Citri Reticulatae 5g, it is clean to merge washing, after just add water to and flood, soak 1h, decocting boils to boiling and keeping boiling 30 minutes then, pouring out water decoction and 60 orders filters, get filtrate, filtering residue is added water to just flood again, and then decocting boils to boiling and keeping boiling 25 minutes, pouring out water decoction and 60 orders filters, get filtrate, standby, waste;
B. take by weighing Radix Paeoniae Alba 6g, add water to just after washing is clean and flood, soak 1.5h, decocting boils to boiling and keeping boiling 15 minutes then, pours out water decoction and 100 orders and filters, get filtrate, again filtering residue is added water to just and flood, and then decocting boils to boiling and keeping boiling 10 minutes, pour out water decoction and 100 orders and filter, get filtrate and filtering residue, standby;
C. a step and b step filtrate are merged, be concentrated into paste;
D. get b step filtering residue add weight concentration be 50% ethanol to just flooding, soak 1.5h, reflux, extract, 20 minutes, 100 orders filter, alcohol extraction filtrate, waste, steam remove ethanol after reconcentration to paste;
E. c step and d step paste are merged, again according to paste: dextrin: weight concentration 97% ethanol=1: 0.2: 0.12 weight portion proportioning adds dextrin and ethanol is made dough, crosses 20 mesh sieve pelletizes at last, 80 ℃ of vacuum drying 1h, vacuum is-0.090, and packing gets product.
Embodiment 2:
A. take by weighing Radix Curcumae 6g, Spica Prunellae 6g, Pericarpium Citri Reticulatae 2g, it is clean to merge washing, after just add water to and flood, soak 1.5h, decocting boils to boiling and keeping boiling 15 minutes then, pouring out water decoction and 100 orders filters, get filtrate, filtering residue is added water to just flood again, and then decocting boils to boiling and keeping boiling 10 minutes, pouring out water decoction and 100 orders filters, get filtrate, standby, waste;
H. take by weighing Radix Paeoniae Alba 15g, add water to just after washing is clean and flood, soak 1h, decocting boils to boiling and keeping boiling 30 minutes then, pours out water decoction and 60 orders and filters, get filtrate, again filtering residue is added water to just and flood, and then decocting boils to boiling and keeping boiling 25 minutes, pour out water decoction and 60 orders and filter, get filtrate and filtering residue, standby;
C. a step and b step filtrate are merged, be concentrated into paste;
D. get b step filtering residue add weight concentration be 70% ethanol to just flooding, soak 0.5h, reflux, extract, 40 minutes, 60 orders filter, alcohol extraction filtrate, waste, steam remove ethanol after reconcentration to paste;
E. c step and d step paste are merged, again according to paste: dextrin: weight concentration 90% ethanol=1: 0.4: 0.08 weight portion proportioning adds dextrin and ethanol is made dough, crosses 20 mesh sieve pelletizes at last, 70 ℃ of vacuum drying 1.5h, vacuum is-0.085, and packing gets product.
Embodiment 3:
A. take by weighing Radix Curcumae 10g, Spica Prunellae 10g, Pericarpium Citri Reticulatae 3g, it is clean to merge washing, after just add water to and flood, soak 1.2h, decocting boils to boiling and keeping boiling 22 minutes then, pouring out water decoction and 80 orders filters, get filtrate, filtering residue is added water to just flood again, and then decocting boils to boiling and keeping boiling 18 minutes, pouring out water decoction and 80 orders filters, get filtrate, standby, waste;
B. take by weighing Radix Paeoniae Alba 10g, add water to just after washing is clean and flood, soak 1.2h, decocting boils to boiling and keeping boiling 20 minutes then, pours out water decoction and 80 orders and filters, get filtrate, again filtering residue is added water to just and flood, and then decocting boils to boiling and keeping boiling 15 minutes, pour out water decoction and 80 orders and filter, get filtrate and filtering residue, standby;
C. a step and b step filtrate are merged, be concentrated into paste;
D. get b step filtering residue add weight concentration be 60% ethanol to just flooding, soak 1h, reflux, extract, 30 minutes, 80 orders filter, alcohol extraction filtrate, waste, steam remove ethanol after reconcentration to paste;
E. c step and d step paste are merged, again according to paste: dextrin: weight concentration 95% ethanol=1: 0.3: 0.1 weight portion proportioning adds dextrin and ethanol is made dough, crosses 20 mesh sieve pelletizes at last, 75 ℃ of vacuum drying 1.2h, vacuum is-0.085, and packing gets product.
Claims (2)
1. hepatoprotective resolving depression granule is characterized in that it is to adopt following raw materials in weight portion and step preparation:
Radix Curcumae 6-15 Radix Paeoniae Alba 6-15 Spica Prunellae 6-15 Pericarpium Citri Reticulatae 2-5;
A. get to add water to just after Radix Curcumae, Spica Prunellae, Pericarpium Citri Reticulatae are cleaned and flood, soak 1-1.5h, decocting boils to boiling and keeping boiling 15-30 minute then, the 60-100 order filters, get filtrate, filtering residue adds water to just and floods, and then decocting boils to boiling and keeping boiling 10-25 minute, the 60-100 order filters, and gets filtrate;
B. get to add water to just after the Radix Paeoniae Alba is cleaned and flood, soak 1-1.5h, decocting boils to boiling and keeping boiling 15-30 minute then, and the 60-100 order filters, get filtrate, filtering residue adds water to just and floods, and then decocting boils to boiling and keeping boiling 10-25 minute, the 60-100 order filters, and gets filtrate and filtering residue, and is standby;
C. a step and b step filtrate are merged, be concentrated into paste;
D. get b step filtering residue add weight concentration be 50-70% ethanol to just flooding, soak 0.5-1.5h, reflux, extract, 20-40 minute, the 60-100 order filter alcohol extraction filtrate, steam and remove ethanol and be concentrated into paste;
E. c step and d step paste are merged, again according to paste: dextrin: weight concentration 90-97% ethanol=1: 0.2-0.4: 0.08-0.12 weight portion proportioning adds dextrin and ethanol is made dough, after pelletize, drying, packing, product.
2. a kind of hepatoprotective resolving depression granule according to claim 1 is characterized in that described drying is 70-80 ℃ of vacuum drying 1-1.5h.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100532550A CN102091300B (en) | 2011-03-07 | 2011-03-07 | Granule for protecting liver and relieving depression |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100532550A CN102091300B (en) | 2011-03-07 | 2011-03-07 | Granule for protecting liver and relieving depression |
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| Publication Number | Publication Date |
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| CN102091300A true CN102091300A (en) | 2011-06-15 |
| CN102091300B CN102091300B (en) | 2012-05-23 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104667164A (en) * | 2013-12-02 | 2015-06-03 | 天津中敖生物科技有限公司 | Traditional Chinese medicine pill for soothing liver and regulating flow of qi and preparation method thereof |
| CN109200251A (en) * | 2018-11-30 | 2019-01-15 | 俞傲然 | A kind of pure Chinese medicine pulvis of liver protecting |
-
2011
- 2011-03-07 CN CN2011100532550A patent/CN102091300B/en not_active Expired - Fee Related
Non-Patent Citations (3)
| Title |
|---|
| 《中医药学刊》 20061130 连建伟等 膏方治疗肝病验案3则 1978 1-2 第24卷, 第11期 2 * |
| 《北京中医》 19961231 车念聪等 中医肝胆病研治新进展概述 49-52 1-2 , 第4期 2 * |
| 《陕西中医》 20031231 常宗范 柴胡疏肝散临床运用举隅 174-175 1-2 第24卷, 第2期 2 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104667164A (en) * | 2013-12-02 | 2015-06-03 | 天津中敖生物科技有限公司 | Traditional Chinese medicine pill for soothing liver and regulating flow of qi and preparation method thereof |
| CN109200251A (en) * | 2018-11-30 | 2019-01-15 | 俞傲然 | A kind of pure Chinese medicine pulvis of liver protecting |
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| Publication number | Publication date |
|---|---|
| CN102091300B (en) | 2012-05-23 |
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