CN104587078A

CN104587078A - Traditional Chinese medicine preparation for treating viral pharyngitis

Info

Publication number: CN104587078A
Application number: CN201510072714.8A
Authority: CN
Inventors: 南艳子
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-02-12
Filing date: 2015-02-12
Publication date: 2015-05-06

Abstract

The invention relates to a traditional Chinese medicine preparation for treating viral pharyngitis. A medicament for oral administration comprises the following active pharmaceutical ingredients: smallfruit balloonvine hearseed herb, folium et ramulus sarcandrae, solidago decurrens, sikudagi canadensis, radices primulae, olive, sanchi flower, pulvis fumi carbonisatus, radix sophorae tonkinensis, caulis clematis armanoii, herba andrographis, Abutilon indicum, indian kalimeris herb, grosvenor momordica leaf, Chinese violet, radix scrophulariae, cortex phellodendri, fresh pears, semen ziziphi spinosae, fructus lycii, chorion ovi, herba taraxaci, catechu, flos lonicerae, and peony; a medicament for external use comprises the following active pharmaceutical ingredients: smallfruit balloonvine hearseed herb, folium et ramulus sarcandrae, solidago decurrens, sikudagi canadensis, radices primulae, sanguis draconis, indigo naturalis, calomelas, sanchi flower, pulvis fumi carbonisatus, radix sophorae tonkinensis, caulis clematis armanoii, herba andrographis, Abutilon indicum, indian kalimeris herb, grosvenor momordica leaf, Chinese violet, radix scrophulariae, cortex phellodendri, chorion ovi, herba taraxaci, catechu, flos lonicerae and peony. All active pharmaceutical ingredients are combined, the efficacy is mild, and the potency is durable, so that the traditional Chinese medicine preparation achieves the efficacies of clearing away heat and detoxifying, inhibiting bacteria and diminishing inflammation, and nourishing yin and clearing internal heat, and the viral pharyngitis can be healed.

Description

A kind of Chinese medicine preparation for the treatment of viral pharyngitis

Technical field

The present invention relates to medicine and pharmacology technical field, specifically a kind of Chinese medicine preparation for the treatment of viral pharyngitis.

Background technology

Acute pharynxinfection caused by viral pharyngitis system virus.How occur at pharyngeal, oral mucosa and surrounding skin thereof herpes, also can betide corneaand external genitalia.Its Pathogen category is a lot, with herpesvirusmore common, have in addition adenovirus, coronavirus, syncytial virus etc.It is corps ronds that this virus is shown under Electronic Speculum, diameter about 180 μm.When overworking, allergic diathesis, temperature suddenlys change, health is suffered from cold or some physics, chemical factor as the stimulation of hydrargyrum, arsenic, bismuth, iodine etc., make passive protective physical fitness low, easily suffer from that this is sick.In addition, acute rhinitis, pneumonia, influenza, malaria, epidemic cerebrospinal meningitisdeng all can concurrent viral pharyngitis.Pathological changes is epithelial cell edema, expansion, and the prickle cell layer of epidermis is swelled, and forms vesicle, include a large amount of multinuclear leucocyte and serum, have acidophilia's inclusion body in nucleus, vesicle is broken very soon, form a fester, surface is covered with inflammatory cell, erythrocyte or slough.

Clinically be divided into acute and chronic two types, more common with acute.

(1) acute onset is anxious, the herpes of needle point size is first there is at places such as pharynx and oral mucosa, tonsil and bickers, rounded or oval, isolate or gather together together, to break very soon formation fester, surface coverage has faint yellow pseudomembrane, and surrounding mucosa is cerise, with fear of cold, heating, pharyngeal scorching hot pain.Infant is cry and screamed uneasiness, and drinking refusal is eaten, and submandibular lymph nodes enlargement also has tenderness.

(2) chronic type is more common in adult, and minority appears in pharynx and oral mucosa herpes, be covered with canescence pseudomembrane after ulceration, surrounding mucosa is light red, and more that rise for this, continue very of a specified duration.The scorching hot pain of the micro-sense in pharyngeal and oral cavity, non-evident sympton.

Pharyngitis, belong to traditional Chinese medical science sore throat category, be a kind of common laryngeal disease, pharyngeal pain is its cardinal symptom.But primary disease usually involves trachea, therefore, cough is also its main clinical manifestation, adopts Syndrome Differentiation of Traditional Chinese Medicine medical treatment, often can obtain good effect.

Clinical in one not only simple but also Chinese medicine composition targetedly, oral, external application Chinese medicine can go directly disease institute, and treating both the principal and secondary aspects of a disease, instant effect, shortens the course of disease.

Summary of the invention

Technical problem to be solved by this invention is, provides that a kind of formula is simple, processing technology is easy, and the little and convenient drug administration of toxic and side effects, medicament is easy to manufacture, new drug with low cost.

A kind of Chinese medicine preparation for the treatment of viral pharyngitis, it is characterized in that, be made up of endo-medicine and external used medicine, in endo-medicine, each crude drug is: Herba Cardiospermi microcarpi, Herba Pileae Scriptae, Herba Asteris Ageratoidis, Herba Solidaginis, Radix Primulae sieboldii, Fructus Canarii albi, flower of Radix Notoginseng, Pulvis Fumi Carbonisatus, Radix Sophorae Tonkinensis, Caulis Clematidis Armandii, Herba Andrographis, Herba abutili indici, Herba Kalimeridis, Folium Momordicae, Herba Violae, Radix Scrophulariae, Cortex Phellodendri, fresh pears, Semen Ziziphi Spinosae, Fructus Lycii, Membrana Follicularis ovi, Herba Taraxaci, catechu, Flos Lonicerae, Flos Moutan; In external used medicine, each crude drug is: Herba Cardiospermi microcarpi, Herba Pileae Scriptae, Herba Asteris Ageratoidis, Herba Solidaginis, Radix Primulae sieboldii, Sanguis Draxonis, Indigo Naturalis, Calomelas, flower of Radix Notoginseng, Pulvis Fumi Carbonisatus, Radix Sophorae Tonkinensis, Caulis Clematidis Armandii, Herba Andrographis, Herba abutili indici, Herba Kalimeridis, Folium Momordicae, Herba Violae, Radix Scrophulariae, Cortex Phellodendri, Membrana Follicularis ovi, Herba Taraxaci, catechu, Flos Lonicerae, Flos Moutan.The same use of all medicines, drug effect is gentle, and the efficacy of a drug is lasting, thus reach heat-clearing and toxic substances removing, anti-inflammation, yin nourishing clear away heart-fire effect of fire, Cure Viruses pharyngitis.The present invention adopts the Chinese crude drug of different properties, has carried out scientific compatibility, can reach desirable therapeutic effect, and safety, toxic and side effects is little, and preparation is simple, focus of going directly, healing time is short, not easily recur after healing, modern pharmacological research also demonstrate that the reasonability of the party's prescription, and clinical to be used for the treatment of acute appendicitis evident in efficacy, suitable with Western medicine effect, clinic further genralrlization.

the property of medicine and the pharmacology of medicine selected by the present invention are respectively:

Herba Cardiospermi microcarpi:

[nature and flavor] are bitter, cold.

1. " Guangxi Chinese herbal medicine ": mildly bitter flavor, cold in nature.

2. " Fujian Chinese herbal medicine ": pungent, cool.

[function cures mainly] heat-clearing and toxic substances removing.

Control pertussis, pharyngolaryngitis, furuncle, eczema, impetigo.

" conventional Chinese herbal medicine color atlas ": treating snakebite, fever of children, whole body bubbles, BAIPAO skin ulcer, hernia.

Herba Pileae Scriptae:

Bitter, pungent, flat.Heat-clearing and toxic substances removing, synthetism of stimulating the menstrual flow.For flu, popular B-mode brain, scorching, cough due to lung-heat, dysentery, acute appendicitis, sore swollen toxin, rheumatic arthritis, traumatic injury.

Herb hyoscine, can heat-clearing and toxic substances removing, expelling wind and activating blood circulation, reducing swelling and alleviating pain, anti-inflammation.Cure mainly influenza, epidemic encephalitis type B, pneumonia, appendicitis, pelvic inflammatory disease, traumatic injury, rheumatic arthritis, amenorrhea, traumatic infection, bacillary dysentery etc.Also in order to treat the malignant tumor such as cancer of pancreas, gastric cancer, rectal cancer, hepatocarcinoma, the esophageal carcinoma, there is alleviation, reduce lump, life-saving, improve the effects such as subjective symptoms, have no side effect.

Herba Asteris Ageratoidis:

Nature and flavor bitter in the mouth pungent cool in nature

Function cures mainly heat-clearing and toxic substances removing eliminating phlegm and relieving cough cooling blood for hemostasis cure mainly cold, fever tonsillitis bronchitis hepatitis dysentery pyretic stranguria heat in blood tells epistaxis carbuncle furunculosis snake bite and insect sting

Antibacterial and antivirus action decoct is to staphylococcus aureus micrococcus catarrhalis and Neisseria have certain inhibitory action external infected by influenza a type Jiangxi, Asia strains prosperous doctor 58-3 strain there is inhibitory action in vitro but in vivo embryo Gallus domesticus then without the phenol red method of mice proves contained Quercetin 0.4g/kg nimbecetin 0.3g/kg there is good phlegm-dispelling functions

Herba Solidaginis:

[meridian distribution of property and flavor] is pungent, bitter, flat.Enter liver, gallbladder two warp.

[function] wind and heat dispersing, anti-inflammation.For anemopyretic cold headache, (wind and cold is avoided) heat-clearing and toxic substances removing, detumescence is except pain.Upper respiratory tract infection, tonsillitis, laryngopharynx swelling and pain, bronchitis, pneumonia, pulmonary tuberculosis hemoptysis, anxious, chronic nephritis, infantile malnutrition, traumatic injury is controlled in external, venom, sore swollen toxin, mastitis, 1, antibacterial action: decoct (causes inflammation of suppurating to staphylococcus aureus in vitro, skin scabies carbuncle, infantile bronchitis), bacillus pyocyaneus (pneumonia), dysentery (acute bacillary dysentery), (intestinal injures Bacillus typhi, avoid and be cautious use of for a long time, easily hemorrhage), Diplococcus pneumoniae (lobar pneumonia), α-hemolytic streptococcus (tonsillitis) and red moss bacterium, Candida albicans (belongs to fungus and causes fungal infection of hand and foot, tinea unguium, tinea pedis, women's colpitis mycotica) all have inhibitory action.

Radix Primulae sieboldii:

[nature and flavor] " Ningxia Chinese herbal medicine handbook ": sweet is flat.

[function cures mainly] reduces phlegm, cough-relieving, relieving asthma.For phlegm dyspnea cough, upper respiratory tract infection, pharyngitis, the diseases such as bronchitis.

Fructus Canarii albi:

[return through] lung; Stomach; Spleen; Liver Channel

[effect] removing heat from the lung and relieving sorethroat; Promoting the production of body fluid to quench thirst; Removing toxic substances

[section belongs to classification] Burseraceae

[curing mainly] cough expectorant blood; Laryngopharynx swelling and pain; Summer-heat excessive thirst; Drunk; Fish Eriocheir sinensis is poisoning

Flower of Radix Notoginseng:

[nature and flavor] are cool in nature, sweet in the mouth, micro-hardship.

[function] be mainly used in heat clearing away, removing toxic substances, removing heat from blood, blood pressure lowering, tune fat, immunomodulating, anti-ageing, the anti-inflammatory analgesic action of blood circulation and channel invigorating, health preserving active ingredient.Have significant suppressing the hyperactive liver, eliminate the phlegm, relieving asthma, sleeping, effect such as coronary dilating, antiallergic, eliminating toxin and beautifying the skin of easing pain.

Pulvis Fumi Carbonisatus:

[nature and flavor] are pungent, temperature

1. " detailed outline ": pungent, temperature, nontoxic.

2. " jade seizes medicine solution ": acrid in the mouth, gas is put down.

3. " medical center bun is wanted ": arduous, temperature.

[chemical analysis] is main containing carbon granules.

[return through]

Enter liver, lung, stomach warp.

1. " book on Chinese herbal medicine is looked for the truth ": enter liver, double enter kidney.

2. " key medicine divides agent ": enter liver, lung, stomach three warp.

[function cures mainly] stops blooding; Removing food stagnancy; Sterilizing powdered medicine fire.Main haematemesis; Epistaxis; Have blood in stool; Metrorrhagia; Leukorrhagia; Food stagnation; Dysentery; Jaundice; Laryngopharynx swelling and pain; aphtha of the mouth and tongue; Ecthyma; White bareheaded skin ulcer; Traumatic hemorrhage.

Radix Sophorae Tonkinensis:

[meridian distribution of property and flavor] sweet in the mouth, cold, enter the heart, lung, large intestine three warp;

[function cures mainly] is nontoxic, relieves inflammation or internal heat, removing toxic substances, detumescence, pain relieving.Control retropharyngeal abscess, acute throat trouble, sore throat, gingival swelling and pain, dyspnea with fullness of the chest heat syndrome cough, jaundice, dysentery, haemorrhoids, heat is swollen, tinea alba, scabies, Serpentis, worm, lyssodexis.

[compatibility of drugs] joins Flos Chrysanthemi, is common to the deficient blurred vision of Liver and kidney and looks forward or upwards and look, and the raw nebula of order, has the merit of improving eyesight.Join Radix Rehmanniae Preparata, mutual reinforcement between is use, is common to the soreness of the waist and knees of hepatic and renal YIN deficiency, menoxenia, seminal emission, and the time of senilism, also can be used for the dizziness of Liver and kidney asthenia of essence and blood, tinnitus, and two blurred vision flowers wait.Join Radix Glehniae, for the cough dry pharynx of lung stomach-Yin wound, deficiency of YIN pulmonary tuberculosis, quenches one's thirst in illness, the time of consumption of YIN caused by febrile disease.Join Fructus Ligustri Lucidi, for the Light-headedness of Liver and kidney asthenia of essence and blood, blurring of vision, the raw nebula of order or sudden blindness, early whitening of beard and hair, soreness of the waist and knees waits, and mutual reinforcement between is for using.Joining Semen Cuscutae, share in controlling deficiency of kidney-essence, two blurred vision flowers of liver blood loss, blind depending on looking forward or upwards dusk, seminal emission premature ejaculation, dizzy tinnitus, lumbago.Join Radix Polygoni Multiflori, flat invigorating the liver and kidney, beneficial essence is enriched blood, the strong muscle of black hair.Join Radix Ophiopogonis, for consumption of YIN caused by febrile disease, lung-dryness syndrome due to deficiency of YIN, the time of quenching one's thirst in illness, has coordinative role.Join Rhizoma Polygonati, can nourishing YIN and supplementing blood, Fructus Lycii helps Rhizoma Polygonati nourishing YIN and moistening the lung, and Rhizoma Polygonati helps Fructus Lycii to nourish cloudy blood, and mutual reinforcement between is for using.

Caulis Clematidis Armandii:

[meridian distribution of property and flavor] is light, bitter, cold.GUIXIN, lung, small intestinal, urinary bladder channel.

[function cures mainly] clearing away heat and promoting diuresis, clear away heart-fire relieving restlessness, stimulating milk secretion of stimulating the menstrual flow.For edema, aphtha of the mouth and tongue, damp and hot arthralgia pain, gonorrhea, urinary obstruction, arthralgia, amenorrhea breast is few.

Herba Andrographis:

[meridian distribution of property and flavor] is bitter, cold, GUIXIN, lung, large intestine, urinary bladder channel.

[function cures mainly] heat-clearing and toxic substances removing, removing heat from blood, detumescence.For cold, fever, laryngopharynx swelling and pain, aphtha of the mouth and tongue, pertussis chronic cough, dysentery, the puckery pain of pyretic stranguria, carbuncle skin infection, venom, treatment neurodermatitis, eczema.

Herba abutili indici:

Sweet in the mouth is light; Cool in nature.There is wind and heat dispersing, preventing phlegm from forming and stopping coughing, effect of subduing swelling and detoxicating.For flu, heating, cough, has loose bowels, otitis media, deaf, pharyngitis, parotitis, urinary tract infection, sore and toxic, traumatic injury.

Herba Kalimeridis:

[meridian distribution of property and flavor] acrid in the mouth, cold nature.Return liver, kidney, stomach, large intestine channel.

[effect] relieves internal heat anticancer, removing heat from blood scattered silt, clearing away heat-damp and promoting diuresis, reducing swelling and alleviating pain.

Energy heat-clearing and toxic substances removing, dissipating blood stasis stops blooding, and dampness removing, helps digestion, removing food stagnancy.For cat fever, cough, acute pharyngitis, tonsillitis, mumps, infectious hepatitis, stomach, duodenal ulcer, infantile malnutrition, enteritis, dysentery, spit blood, metrorrhagia, menoxenia; External is controlled furuncle and is swollen and ache, mastitis, traumatic hemorrhage; Dysentery or damp-heat diarrhea; Laryngopharynx swelling and pain, carbuncle skin infection; Heat in blood epistaxis, to have blood in stool; Jaundice due to damp-heat; Or edema, dysuria; Eating accumulation, distension and fullness in the abdomen.

Folium Momordicae:

[nature and flavor] are sweet, cool, enter lung;

[function cures mainly] detoxifies; Antipruritic.Main sore; Carbuncle; Stubborn dermatitis; Chronic pharyngitis; Chronic bronchitis.

Herba Violae:

[meridian distribution of property and flavor] bitter, pungent, cold, nontoxic; GUIXIN, Liver Channel.

[function] can be used as medicine, its mildly bitter flavor cold in nature, heat-clearing and toxic substances removing, and removing heat from blood is subsided a swelling.Cure mainly jaundice, dysentery, mastitis, conjunctival congestion and swelling pain, pharyngitis; Traumatic injury, carbuncle, poison are controlled in external application serpentisbite.

Radix Scrophulariae:

[meridian distribution of property and flavor] is bitter, sweet, salty, cold, returns lung, stomach, kidney channel;

[effect] YIN nourishing and the production of body fluid promoting, heat-clearing and toxic substances removing; Removing pathogenic heat from blood and toxic substance from the body: be suitable for heat in blood and sore; Heat enters nutrient blood, crimson tongue and doing; Intense heat in both QI and blood systems, pyretic toxicity sends out speckle; Heat falls into pericardium, unconsciousness due to high fever; Wind heat is attacked, laryngopharynx swelling and pain; Pathopyretic ulcer, red and swollen heat pain; Scrofula sucutaneous nodule; Chang Peiwu removing toxic substances and promoting subsidence of swelling eliminating stagnation medicine; Nourishing YIN to lower pathogenic fire: cure mainly yin asthenia generating intrinsic heat; Hyperactivity of fire caused by deficiency of YIN, pharyngeal swelling is spat blood, hectic fever due to YIN-deficiency consumptive fever; Consumption of YIN caused by febrile disease, dysphoria and insomnia, thirsty crimson tongue.

Cortex Phellodendri:

[meridian distribution of property and flavor] is bitter, cold.Return kidney, urinary bladder channel.

[function cures mainly] heat clearing and damp drying, pathogenic fire purging removes steams, detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity { is warded off }, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Stir-baked CORTEX PHELLODENDRI with salt solution nourishing YIN to lower pathogenic fire.For hyperactivity of fire caused by deficiency of YIN, night sweat hectic fever due to YIN-deficiency.

Fresh pears:

[meridian distribution of property and flavor] sweet in the mouth is sour, cool in nature, enters lung, stomach warp;

[function] containing compositions such as more glycocide and tannic acids, can promote the production of body fluid, heat clearing away, expelling phlegm for arresting cough, have maintenance action to throat.

Semen Ziziphi Spinosae:

[nature and flavor] property is put down, sweet in the mouth, acid; GUIXIN, Liver Channel.

[function cures mainly] nourishes heart, and calms the nerves, arresting sweating.For neurasthenia, insomnia, dreaminess, night sweat.

Fructus Lycii:

[meridian distribution of property and flavor] is sweet, flat, enters liver, stomach two warp, double enter lung meridian;

[function cures mainly] the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, blood-enriching tranquillizing, promoting the production of body fluid to quench thirst, nourishing the lung to arrest cough.Cure mainly: control apoplexy dizzy, asthenia, allly see blood disorder, cough blood, flaccidity, faint, contraction, disappear miasma, hinders dry, seminal emission, reddish and whitish turbid urine, beriberi, the arthroncus of knee.

Membrana Follicularis ovi:

[meridian distribution of property and flavor] be " decoction pieces is newly joined " 1.: " light, flat." 2. " Traditional Chinese Medicine in Sichuan will ": " warm in nature, sweet in the mouth is nontoxic." enter lung, spleen, stomach warp.1. " about mirror can be cured ": " enter lung." 2. " Traditional Chinese Medicine in Sichuan will ": " enter spleen, stomach, lung three warp.”

[curing mainly] controls chronic cough, pharyngalgia aphonia, scrofula tuberculosis, ulcer being unable to heal.

Calomelas:

[nature and flavor] are pungent, cold, poisonous.1. " praise and help book on Chinese herbal medicine ": be " pungent, cold, nontoxic." 2. " Elementary Medicine ": " is poisonous." 3. " Bencao Congxin ": " is pungent cold and dry, poisonous."

[return through] enters liver, kidney channel.1. " beautiful Chinese catalpa medicine solution ": " enter kidney meridian, liver channel of foot-Jueyin." 2. " book on Chinese herbal medicine is new again ": enter liver, lung two warp.

[function] parasite killing, counteracting toxic substances, diuretic, relieving constipation.Control scabies, scrofula, syphilis, primary sore, skin ulcer, edema, tympanites, defecation is closed.1. supplement to the Herbal: " logical large intestine, turns children's's infantile malnutrition and scrofula, kill wine acne on skin ulcer copperworm and nose, wind skin ulcer pruritus." 2. amplification on Canon of Materia Medica: " descends saliva medicine and children's's saliva tide, Chi Zong is multiplex." 3. Zhang Yuansu: " promoting diuresis to alleviate water retention, goes dirt in bladder greasy." 4. " Elementary Medicine ": " consumer edema, hemostasis dysentery, tells wind saliva." 5. " detailed outline ": " is controlled sputum and is stagnated, edema tympanites, skin infection." 6. " book on Chinese herbal medicine just ": " controls all skin infection of scrofula, removing the necrotic tissue meat, tissue regeneration promoting meat.

Sanguis Draxonis:

Another name: black horse Lin exhausts, sea wax, dragon's blood, wooden Sanguis Draxonis.

[effect] takes promoting blood circulation to remove blood stasis orally, analgesic therapy, external hemostasia and promoting granulation, sore.

[curing mainly]

1. congestion amenorrhea, dysmenorrhea, postpartum stagnation.

2. lump in the abdomen mass in the abdomen, breast ventral spine pain.

3. traumatic injury, congestion swells and ache.

4. traumatic hemorrhage, ulcer being unable to heal.

[meridian distribution of property and flavor]

Gan Xian is flat.Enter the heart, liver, spleen channel.

Herba Taraxaci:

[nature and flavor] are sweet, micro-hardship, cold.

[curing mainly] heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, upper respiratory tract infection, eye conjunctivitis, mumps, acute mastitis swells and ache, gastritis, dysentery, hepatitis, gallbladder assists inflammation, acute appendicitis, urinary system infection, pelvic inflammatory disease, carbuncle furuncle furuncle, and pharyngitis, controls acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, urinary tract infection.

Catechu:

[meridian distribution of property and flavor] is bitter, puckery, is slightly cold.Return lung meridian.

[function cures mainly] removing dampness promoting tissue regeneration and ulcer healing, for ulcer being unable to heal, eczema, aphtha, traumatic pain, traumatic hemorrhage.

Flos Lonicerae:

[nature and flavor] property is sweet, cold;

[function] has heat clearing away, removing toxic substances, antiinflammatory, antibacterial effect.Compendium of Material Medica is carried " Flos Lonicerae, is good at removing toxic substances, therefore controls carbuncle, toxic swelling, skin ulcer tinea ... ".Since ancient times, Flos Lonicerae is usually used in heat-clearing and toxic substances removing, the heating for the treatment of epidemic febrile disease, toxic-heat and blood stasis, the diseases such as carbuncle and ulcer, also for anemopyretic cold, and the diseases such as bronchitis.Modern pharmacological research shows, Flos Lonicerae has the effect such as antibacterial, antiviral, antiinflammatory, antipyretic, immunity moderation.

The loose poison of heat clearing away, Compendium of Material Medica is carried " Flos Lonicerae, is good at removing toxic substances, therefore controls carbuncle, toxic swelling, skin ulcer tinea ... ".Since ancient times, Flos Lonicerae is usually used in heat-clearing and toxic substances removing, the heating for the treatment of epidemic febrile disease, toxic-heat and blood stasis, the diseases such as carbuncle and ulcer.Modern pharmacological research shows, Flos Lonicerae has the effect traditional Chinese medical science such as antibacterial, antiviral, antiinflammatory, antipyretic, immunity moderation and thinks, Flos Lonicerae is cold in nature, sweet in the mouth, gas flat, has effect of heat-clearing and toxic substances removing, can treat the disease such as pyretic toxicity abscess, carbuncle furuncle.And have the loose effect of a surname concurrently.Flos Lonicerae antipyretic and antidote functions is quite strong.Flos Lonicerae can delay the pathological changes effect of Respirovirus to cell, is the representative medicine of heat-clearing and toxic substances removing, and pyretic toxicity essence is except containing multiple pathogenic microorganism, and microbial toxin also accounts for critical positions.Caused by the endotoxin that Flos Lonicerae preparation lumbar injection obviously can reduce bacillus pyocyaneus, the leukocyte count of rabbit declines, and deviation to the left phenomenon etc. has obvious antagonism.Flos Lonicerae compatibility Radix Scutellariae is prepared into poisoning symptom and the death that preparation obviously can alleviate bacillus pyocyaneus endotoxin caused rabbit.

Flos Moutan:

Paeonia suffruticosa not only has ornamental value, but also has very high medical value.Being processed into " Cortex Moutan " by the root of Paeonia suffruticosa, is famous and precious chinese herbal medicine.Its cold nature, acrid in the mouth, nontoxic, enter the heart, liver, kidney three warp, have dissipating blood stasis blood, purify the blood and blood, pain relieving, the effect of stimulating the menstrual flow, reduce blood pressure in addition, antibacterialeffect of antiinflammatory, clothes can beneficial body for a long time lengthen the life.Nourish blood regulating liver-QI, loose strongly fragrant blood stasis dispelling, is applicable to face chloasma, skin aging, normal drink QI and blood lung alive, appearance is ruddy, improves menoxenia, dysmenorrhea, only sweating due to debility, night sweat.

Indigo Naturalis:

[meridian distribution of property and flavor] is salty, cold.Return Liver Channel.

[function cures mainly] heat-clearing and toxic substances removing, removing heat from blood, arresting convulsion.For maculae caused by violent heat pathogen, heat in blood tells nosebleed, chest pain hemoptysis, aphtha, mumps, sore throat, pediatric epilepsy scared.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of viral pharyngitis, it is characterized in that, being made up of endo-medicine and external used medicine,

In described endo-medicine, the ratio of weight and number of various crude drug is: Herba Cardiospermi microcarpi 1.0-10 part, Herba Pileae Scriptae 1.0-10 part, Herba Asteris Ageratoidis 1.0-10 part, Herba Solidaginis 1.0-10 part, Radix Primulae sieboldii 1.0-10 part, Fructus Canarii albi 1.0-10 part, flower of Radix Notoginseng 1.0-10 part, Pulvis Fumi Carbonisatus 1.0-10 part, Radix Sophorae Tonkinensis 1.0-10 part, Caulis Clematidis Armandii 1.0-10 part, Herba Andrographis 1.0-10 part, Herba abutili indici 1.0-10 part, Herba Kalimeridis 1.0-10 part, Folium Momordicae 1.0-10 part, Herba Violae fourth 0.5-5.0 part, Radix Scrophulariae 0.5-5.0 part, Cortex Phellodendri 0.5-5.0 part, fresh pears 0.5-5.0 part, Semen Ziziphi Spinosae 0.5-5.0 part, Fructus Lycii 0.5-5.0 part, Membrana Follicularis ovi 0.5-5.0 part, Herba Taraxaci 0.5-5.0 part, catechu 0.5-5.0 part, Flos Lonicerae 0.5-5.0 part, Flos Moutan 0.5-5.0 part,

In described external used medicine, the ratio of weight and number of various crude drug is: Herba Cardiospermi microcarpi 1.0-10 part, Herba Pileae Scriptae 1.0-10 part, Herba Asteris Ageratoidis 1.0-10 part, Herba Solidaginis 1.0-10 part, Radix Primulae sieboldii 1.0-10 part, Sanguis Draxonis 1.0-2.0 part, Indigo Naturalis 1.0-10 part, Calomelas 1.0-3.0 part, flower of Radix Notoginseng 1.0-10 part, Pulvis Fumi Carbonisatus 1.0-10 part, Radix Sophorae Tonkinensis 1.0-10 part, Caulis Clematidis Armandii 1.0-10 part, Herba Andrographis 1.0-10 part, Herba abutili indici 1.0-10 part, Herba Kalimeridis 1.0-10 part, Folium Momordicae 1.0-10 part, Herba Violae fourth 0.5-5.0 part, Radix Scrophulariae 0.5-5.0 part, Cortex Phellodendri 0.5-5.0 part, Membrana Follicularis ovi 0.5-5.0 part, Herba Taraxaci 0.5-5.0 part, catechu 0.5-5.0 part, Flos Lonicerae 0.5-5.0 part, Flos Moutan 0.5-5.0 part.

In described endo-medicine, the ratio of weight and number of various crude drug can be: Herba Cardiospermi microcarpi 2.0-8.0 part, Herba Pileae Scriptae 2.0-8.0 part, Herba Asteris Ageratoidis 2.0-8.0 part, Herba Solidaginis 2.0-8.0 part, Radix Primulae sieboldii 2.0-8.0 part, Fructus Canarii albi 2.0-8.0 part, flower of Radix Notoginseng 2.0-8.0 part, Pulvis Fumi Carbonisatus 2.0-8.0 part, Radix Sophorae Tonkinensis 2.0-8.0 part, Caulis Clematidis Armandii 2.0-8.0 part, Herba Andrographis 2.0-8.0 part, Herba abutili indici 2.0-8.0 part, Herba Kalimeridis 2.0-8.0 part, Folium Momordicae 2.0-8.0 part, Herba Violae fourth 1.0-3.0 part, Radix Scrophulariae 1.0-3.0 part, Cortex Phellodendri 1.0-3.0 part, fresh pears 1.0-3.0 part, Semen Ziziphi Spinosae 1.0-3.0 part, Fructus Lycii 1.0-3.0 part, Membrana Follicularis ovi 1.0-3.0 part, Herba Taraxaci 1.0-3.0 part, catechu 1.0-3.0 part, Flos Lonicerae 1.0-3.0 part, Flos Moutan 1.0-3.0 part,

In described external used medicine, the ratio of weight and number of various crude drug can be: Herba Cardiospermi microcarpi 2.0-8.0 part, Herba Pileae Scriptae 2.0-8.0 part, Herba Asteris Ageratoidis 2.0-8.0 part, Herba Solidaginis 2.0-8.0 part, Radix Primulae sieboldii 2.0-8.0 part, Sanguis Draxonis 2.0-8.0 part, Indigo Naturalis 2.0-8.0 part, Calomelas 1.5-2.5 part, flower of Radix Notoginseng 2.0-8.0 part, Pulvis Fumi Carbonisatus 2.0-8.0 part, Radix Sophorae Tonkinensis 2.0-8.0 part, Caulis Clematidis Armandii 2.0-8.0 part, Herba Andrographis 2.0-8.0 part, Herba abutili indici 2.0-8.0 part, Herba Kalimeridis 2.0-8.0 part, Folium Momordicae 2.0-8.0 part, Herba Violae fourth 1.0-3.0 part, Radix Scrophulariae 1.0-3.0 part, Cortex Phellodendri 1.0-3.0 part, Membrana Follicularis ovi 1.0-3.0 part, Herba Taraxaci 1.0-3.0 part, catechu 1.0-3.0 part, Flos Lonicerae 1.0-3.0 part, Flos Moutan 1.0-3.0 part.

Described a kind of Chinese medicine preparation for the treatment of viral pharyngitis, in described endo-medicine, the ratio of weight and number of various crude drug can also be: Herba Cardiospermi microcarpi 5.0 parts, Herba Pileae Scriptae 5.0 parts, Herba Asteris Ageratoidis 5.0 parts, Herba Solidaginis 5.0 parts, Radix Primulae sieboldii 5.0 parts, Fructus Canarii albi 5.0 parts, flower of Radix Notoginseng 5.0 parts, Pulvis Fumi Carbonisatus 5.0 parts, Radix Sophorae Tonkinensis 5.0 parts, Caulis Clematidis Armandii 5.0 parts, Herba Andrographis 5.0 parts, Herba abutili indici 5.0 parts, Herba Kalimeridis 5.0 parts, Folium Momordicae 5.0 parts, Herba Violae fourth 2.0 parts, Radix Scrophulariae 2.0 parts, Cortex Phellodendri 2.0 parts, fresh pears 2.0 parts, Semen Ziziphi Spinosae 2.0 parts, Fructus Lycii 2.0 parts, Membrana Follicularis ovi 2.0 parts, Herba Taraxaci 2.0 parts, 2.0 parts, catechu, Flos Lonicerae 2.0 parts, Flos Moutan 2.0 parts,

In described external used medicine, the ratio of weight and number of various crude drug can also be: Herba Cardiospermi microcarpi 5.0 parts, Herba Pileae Scriptae 5.0 parts, Herba Asteris Ageratoidis 5.0 parts, Herba Solidaginis 5.0 parts, Radix Primulae sieboldii 5.0 parts, Sanguis Draxonis 5.0 parts, Indigo Naturalis 5.0 parts, Calomelas 2.0 parts, flower of Radix Notoginseng 5.0 parts, Pulvis Fumi Carbonisatus 5.0 parts, Radix Sophorae Tonkinensis 5.0 parts, Caulis Clematidis Armandii 5.0 parts, Herba Andrographis 5.0 parts, Herba abutili indici 5.0 parts, Herba Kalimeridis 5.0 parts, Folium Momordicae 5.0 parts, Herba Violae fourth 2.0 parts, Radix Scrophulariae 2.0 parts, Cortex Phellodendri 2.0 parts, Membrana Follicularis ovi 2.0 parts, Herba Taraxaci 2.0 parts, 2.0 parts, catechu, Flos Lonicerae 2.0 parts, Flos Moutan 2.0 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of viral pharyngitis, and the dosage form of described oral preparations is that sweet preparation method of refining pill comprises:

A, first by Flos Lonicerae, Herba Asteris Ageratoidis, Herba Solidaginis, flower of Radix Notoginseng, Flos Moutan, Herba Kalimeridis distillation crystallize into powder;

B, get surplus stock medicine again and put into soak with ethanol, heat is extracted 2 times, and becoming extractum shape, is component 1;

C, medicinal residues extracting in water 1 time, thickening filtration is extractum shape, is component 2;

D, above-mentioned two kinds of extractum are condensed into pasty state, add the powder that a step obtains, add Mel and be twisted into pill.

In described step b, get the 60-90% soak with ethanol 1-2 hour that crude drug adds 5-10 times amount, heating extraction 2 times, each 1-2 hour, removes supernatant, merge extractive liquid, 80-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extracts active ingredient, concentrated solution is settled into pasty state, mass continues heating and is concentrated into extractum shape, stand for standby use, becomes component 1; In described step c, medicinal residues add 5-10 times amount water soaking 1-2 hour, within 1-1.5 hour, extract 1 time, as component 2.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of viral pharyngitis, and the form of Chinese drug of described oral preparations is that the preparation method of soup potus comprises:

Each component is pulverized respectively, be mixed in proportion, obtain mixture, add water to and flood mixture powder 3 ~ 5cm, soak 1 ~ 2 hour, heating decocts, boil rear slow fire, decoct 2 ~ 4 hours after boiling for the first time, leach medicinal liquid, again add water in filtering residue and flood mixture powder 3 ~ 5cm, heated and boiled, boils rear slow fire, and second time decocts 1 ~ 2 hour after boiling, filter, merge the medicinal liquid of twice filtration, centrifugal 30 minutes ~ 1 hour, extract supernatant, being concentrated into crude drug concentration is 1g/ml ~ 2g/ml, obtains soup potus.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of viral pharyngitis, and the form of Chinese drug of described Chinese medicine preparation is that the preparation method of capsule comprises:

A, all crude drug are put into ethanol heating and refluxing extraction;

B, again by medicinal residues water heating and refluxing extraction;

C, above-mentioned two kinds of extracting solution to be merged, decompression recycling ethanol concentrated sucking filtration absorption, obtain medicated powder.

In described step a, raw medicinal material can be put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extract active ingredient, 2 extracting solution are merged filtering and standing; In described step b, the medicinal residues refined can be put into 10 times of water gagings, heating and refluxing extraction 3 times, each 45 minutes ~ 1 hour, 3 extracting solution be merged, filtering and standing.

In described step c, above-mentioned two kinds of filtrates can be merged, decompression recycling ethanol to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.06; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains raw material medicated powder and incapsulate.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of viral pharyngitis, and the form of Chinese drug of described external medicine preparation is that the preparation method of collutory comprises:

First Sanguis Draxonis, Indigo Naturalis, Calomelas are crushed to 300-400 order fine powder, surplus stock medical material steam method are distilled, obtains crystal; Then distillation test residue is put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extract active ingredient, 2 extracting solution are merged filtering and standing, removes supernatant; The crystal of distillation extraction and the fine powder after pulverizing are put into filtrate, soaks and obtain collutory liquid in 5-10 days.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine preparation of viral pharyngitis, it is characterized in that: the form of Chinese drug of described endo-medicine preparation is that the preparation method of buccal tablet comprises:

Flos Lonicerae, Herba Asteris Ageratoidis, Herba Solidaginis, flower of Radix Notoginseng, Flos Moutan, Herba Kalimeridis are put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extract active ingredient, 2 extracting solution are merged and leaves standstill; 10 times of water gagings put into by the surplus stock got again in above-mentioned side, heating and refluxing extraction 3 times, each 30 minutes ~ 1 hour, merged by 3 extracting solution and leave standstill the heating and refluxing extraction that adds water; Merged by above-mentioned two kinds of extracting solution, decompression recycling ethanol to be concentrated into liquor strength be 0.5g crude drug/mL, after sucking filtration, the relative density of filtrate is about 1.08 (20 DEG C); Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains crude drug; Add starch or dextrin tabletting.

For solving the problems of the technologies described above, the present invention also provides a kind of dosage form for the treatment of the Chinese medicine preparation of viral pharyngitis, and pharmaceutical dosage form can also be: sugar coated tablet, film coated tablet, enteric coated tablet, capsule, oral liquid, suck agent, granule, electuary, powder, sublimed preparation, solution, suppository, plaster, syrup, powder.

detailed description of the invention:

1. wind heat: disease is seen pharyngeal red, swollen, bitterly, dysphagia, cough, expectorant Huang is thick, with sending out medical science religion | and educate net and collect finishing heat, aversion to cold, red tongue, yellow and thin fur, floating and rapid pulse.Pharynx rear wall lymph follicle is red and swollen, and yellow-white point-like exudate appears in the lymph follicle central authorities of swelling.

2. wind and cold: disease sees throat hypodynia, swallow not smooth, cough expectorant is white, and sees that aversion to cold is had a headache, light red tongue, white and thin fur, floating and tense pulse.The swelling of pharynx rear wall lymph follicle is micro-red.

3. phlegm-damp: many obesities of patient size or for a long time addicted to food delicious food savoury food, Chang Zijue pharyngeal swallow is unfavorable, and if any expectorant shape, the white thickness of cough expectorant, light red tongue, corpulent tongue, tongue is white thick greasy, rolling pulse.Pharynx rear wall follicle hypertrophy, mucosa is plump.

4. stagnation of liver-QI: feelings will is passionnate usually for patient, irritability, uncomfortable in normal feel pharynx, if any foreign body, cough expectorant difficulty brings up.Even can cause vomiting when firmly coughing, tongue limit is dark red, white and thin fur, stringy pulse.Pharyngeal mucous layer chronic congestion, rear wall follicle hypertrophy, mucous gland is loose, hypersecretion.

5. the deficiency of YIN: patient age is bigger than normal, uncomfortable in Chang Zijue pharynx, hypodynia is dry itches and have burning sensation, often draws medical science religion because of itching throat | educate net and collect and has arranged cough, easy irriate causes nausea, retches, and how increasing the weight of at nightfall, red tongue tongue is few, thready and rapid pulse.During inspection, pharyngeal sensitivity, easily causes nausea, the mucosa drying of pharynx rear wall or atrophy.

Therefore the present invention is in conjunction with above-mentioned syndrome, have studied a kind of new drug, a kind of Chinese medicine preparation for the treatment of viral pharyngitis, and formula is simple, processing technology is easy, the little and convenient drug administration of toxic and side effects, and medicament is easy to manufacture, new drug with low cost.

A kind of Chinese medicine preparation for the treatment of viral pharyngitis, it is characterized in that, be made up of endo-medicine and external used medicine, in endo-medicine, each crude drug is: the medicine heat-clearing and toxic substances removing, the anti-inflammation that are the monarch and his subjects with Herba Cardiospermi microcarpi, Herba Pileae Scriptae, Herba Asteris Ageratoidis, Herba Solidaginis, Radix Primulae sieboldii, Fructus Canarii albi, flower of Radix Notoginseng, Pulvis Fumi Carbonisatus, Radix Sophorae Tonkinensis, Caulis Clematidis Armandii, Herba Andrographis, Herba abutili indici, Herba Kalimeridis, Folium Momordicae, Herba Violae; With Radix Scrophulariae, Cortex Phellodendri, fresh pears, Semen Ziziphi Spinosae, Fructus Lycii, Membrana Follicularis ovi, Herba Taraxaci, catechu, Flos Lonicerae, medicine nourishing YIN to lower pathogenic fire, the depressed liver-energy dispersing and QI regulating of Flos Moutan for assisting a ruler in governing a country; In external used medicine, each crude drug is: with effect of Herba Cardiospermi microcarpi, Herba Pileae Scriptae, Herba Asteris Ageratoidis, Herba Solidaginis, Radix Primulae sieboldii, Sanguis Draxonis, Indigo Naturalis, Calomelas, flower of Radix Notoginseng, Pulvis Fumi Carbonisatus, Radix Sophorae Tonkinensis, Caulis Clematidis Armandii, Herba Andrographis, Herba abutili indici, Herba Kalimeridis, Folium Momordicae, medicine anti-inflammation that Herba Violae is the monarch and his subjects, virus killing, anti-bacteria virus is grown, with Radix Scrophulariae, Cortex Phellodendri, Membrana Follicularis ovi, Herba Taraxaci, catechu, Flos Lonicerae, the medicine reinforcement drug effect of Flos Moutan for assisting a ruler in governing a country.The same use of all medicines, drug effect is gentle, and the efficacy of a drug is lasting, treating both the principal and secondary aspects of a disease, from inside to outside, thus reach heat-clearing and toxic substances removing, anti-inflammation, yin nourishing clear away heart-fire effect of fire, reach the object of Cure Viruses pharyngitis.The present invention adopts the Chinese crude drug of different properties, has carried out scientific compatibility, can reach desirable therapeutic effect, and safety, toxic and side effects is little, and preparation is simple, focus of going directly, healing time is short, not easily recur after healing, modern pharmacological research also demonstrate that the reasonability of the party's prescription, and clinical to be used for the treatment of acute appendicitis evident in efficacy, suitable with Western medicine effect, clinic further genralrlization.

embodiment 1:endo-medicine formula: Herba Cardiospermi microcarpi 1.0g, Herba Pileae Scriptae 1.0g, Herba Asteris Ageratoidis 1.0g, Herba Solidaginis 1.0g, Radix Primulae sieboldii 1.0g, Fructus Canarii albi 1.0g, flower of Radix Notoginseng 1.0g, Pulvis Fumi Carbonisatus 1.0g, Radix Sophorae Tonkinensis 1.0g, Caulis Clematidis Armandii 1.0g, Herba Andrographis 1.0g, Herba abutili indici 1.0g, Herba Kalimeridis 1.0g, Folium Momordicae 1.0g, Herba Violae fourth 0.5g, Radix Scrophulariae 0.5g, Cortex Phellodendri 0.5g, fresh pears 0.5g, Semen Ziziphi Spinosae 0.5g, Fructus Lycii 0.5g, Membrana Follicularis ovi 0.5g, Herba Taraxaci 0.5g, catechu 0.5g, Flos Lonicerae 0.5g, Flos Moutan 0.5g,

Wherein endo-medicine is honey refining pill, and preparation method is as follows:

B, get the 60-90% soak with ethanol 1-2 hour that surplus stock medicine adds 5-10 times amount, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into pasty state, mass continues heating and is concentrated into extractum shape, stand for standby use, becomes component 1;

C, medicinal residues add 5-10 times amount water soaking 1-2 hour, within 1-1.5 hour, extract 1 time, as component 2;

Topical formulations: Herba Cardiospermi microcarpi 1.0g, Herba Pileae Scriptae 1.0g, Herba Asteris Ageratoidis 1.0g, Herba Solidaginis 1.0g, Radix Primulae sieboldii 1.0g, Sanguis Draxonis 1.0g, Indigo Naturalis 1.0g, Calomelas 1.0g, flower of Radix Notoginseng 1.0g, Pulvis Fumi Carbonisatus 1.0g, Radix Sophorae Tonkinensis 1.0g, Caulis Clematidis Armandii 1.0g, Herba Andrographis 1.0g, Herba abutili indici 1.0g, Herba Kalimeridis 1.0g, Folium Momordicae 1.0g, Herba Violae fourth 0.5g, Radix Scrophulariae 0.5g, Cortex Phellodendri 0.5g, Membrana Follicularis ovi 0.5g, Herba Taraxaci 0.5g, catechu 0.5g, Flos Lonicerae 0.5g, Flos Moutan 0.5g,

Wherein exterior-applied formulation is mouth rinse solution agent, and preparation method is as follows:

Treatment model case:

Patient 42 years old, patient age is bigger than normal, uncomfortable in Chang Zijue pharynx, hypodynia is dry itches and have burning sensation, and often cause cough because of itching throat, retch, how increasing the weight of at nightfall, red tongue tongue is few, thready and rapid pulse.During inspection, pharyngeal sensitivity, easily causes nausea, and pharynx rear wall mucosa is dry.Take Chinese medicine preparation of the present invention honey refining pill one day three ball and divide three times, melt with warm water and take, heat-clearing and toxic substances removing, anti-inflammation, add and use collutory every day five times, treat, seven days courses for the treatment of, fully recover after two courses for the treatment of, consolidate 1 month again, follow up a case by regular visits to so far and do not recur.

embodiment 2,endo-medicine formula: Herba Cardiospermi microcarpi 5.0g, Herba Pileae Scriptae 5.0g, Herba Asteris Ageratoidis 5.0g, Herba Solidaginis 5.0g, Radix Primulae sieboldii 5.0g, Fructus Canarii albi 5.0g, flower of Radix Notoginseng 5.0g, Pulvis Fumi Carbonisatus 5.0g, Radix Sophorae Tonkinensis 5.0g, Caulis Clematidis Armandii 5.0g, Herba Andrographis 5.0g, Herba abutili indici 5.0g, Herba Kalimeridis 5.0g, Folium Momordicae 5.0g, Herba Violae fourth 2.0g, Radix Scrophulariae 2.0g, Cortex Phellodendri 2.0g, fresh pears 2.0g, Semen Ziziphi Spinosae 2.0g, Fructus Lycii 2.0g, Membrana Follicularis ovi 2.0g, Herba Taraxaci 2.0g, catechu 2.0g, Flos Lonicerae 2.0g, Flos Moutan 2.0g,

The preparation method of oral medicine soup potus comprises:

Topical formulations: Herba Cardiospermi microcarpi 5.0g, Herba Pileae Scriptae 5.0g, Herba Asteris Ageratoidis 5.0g, Herba Solidaginis 5.0g, Radix Primulae sieboldii 5.0g, Sanguis Draxonis 5.0g, Indigo Naturalis 5.0g, Calomelas 2.0g, flower of Radix Notoginseng 5.0g, Pulvis Fumi Carbonisatus 5.0g, Radix Sophorae Tonkinensis 5.0g, Caulis Clematidis Armandii 5.0g, Herba Andrographis 5.0g, Herba abutili indici 5.0g, Herba Kalimeridis 5.0g, Folium Momordicae 5.0g, Herba Violae fourth 2.0g, Radix Scrophulariae 2.0g, Cortex Phellodendri 2.0g, Membrana Follicularis ovi 2.0g, Herba Taraxaci 2.0g, catechu 2.0g, Flos Lonicerae 2.0g, Flos Moutan 2.0g,

Treatment model case:

Patient 28 years old, pharyngeal swallow is unfavorable, and if any expectorant shape, the white thickness of cough expectorant, light red tongue, corpulent tongue, tongue is white thick greasy, rolling pulse.Pharynx rear wall follicle hypertrophy, mucosa is plump.Bottleneck throat ulcer area increases, and takes the every natural gift of Chinese medicine preparation soup potus of the present invention and takes for three times, heat-clearing and toxic substances removing, anti-inflammation, add and use collutory every day five times, treat, seven days courses for the treatment of, fully recover after two courses for the treatment of, consolidate 1 month again, follow up a case by regular visits to so far and do not recur.

embodiment 3,endo-medicine formula: Herba Cardiospermi microcarpi 10g, Herba Pileae Scriptae 10g, Herba Asteris Ageratoidis 10g, Herba Solidaginis 10g, Radix Primulae sieboldii 10g, Fructus Canarii albi 10g, flower of Radix Notoginseng 10g, Pulvis Fumi Carbonisatus 10g, Radix Sophorae Tonkinensis 10g, Caulis Clematidis Armandii 10g, Herba Andrographis 10g, Herba abutili indici 10g, Herba Kalimeridis 10g, Folium Momordicae 10g, Herba Violae fourth 5.0g, Radix Scrophulariae 5.0g, Cortex Phellodendri 5.0g, fresh pears 5.0g, Semen Ziziphi Spinosae 5.0g, Fructus Lycii 5.0g, Membrana Follicularis ovi 5.0g, Herba Taraxaci 5.0g, catechu 5.0g, Flos Lonicerae 5.0g, Flos Moutan 5.0g,

Wherein oral medicine is that the preparation method of buccal tablet comprises:

Topical formulations: Herba Cardiospermi microcarpi 10g, Herba Pileae Scriptae 10g, Herba Asteris Ageratoidis 10g, Herba Solidaginis 10g, Radix Primulae sieboldii 10g, Sanguis Draxonis 2.0g, Indigo Naturalis 10g, Calomelas 3.0g, flower of Radix Notoginseng 10g, Pulvis Fumi Carbonisatus 10g, Radix Sophorae Tonkinensis 10g, Caulis Clematidis Armandii 10g, Herba Andrographis 10g, Herba abutili indici 10g, Herba Kalimeridis 10g, Folium Momordicae 10g, Herba Violae fourth 5.0g, Radix Scrophulariae 5.0g, Cortex Phellodendri 5.0g, Membrana Follicularis ovi 5.0g, Herba Taraxaci 5.0g, catechu 5.0g, Flos Lonicerae 5.0g, Flos Moutan 5.0g;

Treatment model case: patient 45 years old, feelings will is passionnate usually for patient, irritability, uncomfortable in normal feel pharynx, and if any foreign body, cough expectorant difficulty brings up.Even can cause vomiting when firmly coughing, tongue limit is dark red, white and thin fur, stringy pulse.Pharyngeal mucous layer chronic congestion, rear wall follicle hypertrophy, mucous gland is loose, and hypersecretion, visible ulcer area is full of whole pharyngeal.Give Drug therapy of the present invention, one day three slices points three times, suck and take, then add collutory one day five times, take a turn for the better day by day, 2 courses for the treatment of, symptom disappears completely, recurs again, consolidate again 1 course for the treatment of, follow up a case by regular visits to so far and do not recur for anti-.

Pharmacological toxicity is tested

Acute toxicity testing data

1, experimental technique

Depilatory is evenly coated by guinea pig back spinal column both sides, makes unhairing scope about 20 square centimeters.Clean depilatory returns cage to observe 24 hours, often organize the Chinese medicine mouth wash solution of the present invention 0.2,0.4 that is coated with respectively of Cavia porcellus and 0.8ml, respectively containing crude drug 92mg, 184mg and 368mg, another group is coated with the every twice-daily of solvent 0.8ml, continuous one week, after experiment terminates, Cavia porcellus is put to death, the heart, liver, kidney and depilation skin do pathological examination.

2, result

Above-mentioned three groups of medication Cavia porcellus trunks depilation district, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group Cavia porcellus chroma of hair, ingest, the matched group no significant difference such as extremity are movable, histopathologic examination, the administration group heart, liver, kidney and depilation skin with contrast word more also no significant difference.

Result is pointed out, and Chinese medicine of the present invention, without local irritant effect, also has no general toxicity performance.Show Chinese medicine preparation use safety of the present invention.

Long term toxicity test data

1, experimental technique

Random for Cavia porcellus part is become 4 groups, often organizes 15.In guinea pig back spinal column both sides, depilatory is evenly coated, make its scope about 20 square centimeters of losing hair or feathers.Clean depilatory, observe and often organize Cavia porcellus after 24 hours and be coated with innerwear Chinese medicine preparation capsule 0.2,0.4 of the present invention and 0.8ml respectively, respectively containing crude drug 92,184 and 368mg), another group is coated with the every twice-daily of solvent 0.8ml, continuous 30 days, observe the ordinary circumstance of Cavia porcellus, experiment terminates rear execution animal and carries out hematology, blood biochemical and pathological examination.

2, result

Above-mentioned three groups of medication Cavia porcellus trunk unhairing districts, having no local skin has edema, hyperemia, erythema, petechia and ulcer.Medication group and control animals chroma of hair, ingest, the matched group no significant difference such as extremity are movable, blood biochemistry checking, medication group and matched group are all in normal range.Histopathologic examination, tests each group of heart, liver, kidney and local skin and is showed no obvious pathological changes.Prompting, Chinese medicine preparation long-term prescription of the present invention is showed no obvious toxic action to local skin and whole body important organ.Result of the test shows: Chinese medicine preparation experiment safety of the present invention.

Aggregate toxicity is tested:

Chinese medicine preparation tablet of the present invention presses 7.69,19.18 and 43.21g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to rat all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and each internal organs of rat are all without obviously changing.Illustrate that Chinese medicine preparation tablet of the present invention is little to toxicity after rat long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data

1 object and method

1.1 subject patient 200 examples, are divided into matched group 5O example at random, man 35 example, female 15 example, treatment group 150 example, man 90 example, female 60 example, two groups of ages all 18-60 year between.

1.2 diagnostic criterias are with reference to clinical manifestation:

Clinically be divided into acute and chronic two types, more common with acute.

1.3 Therapeutic Method treatment groups: take buccal tablet of the present invention, natural gift three times are taken, the one day five times treatments of additional collutory, seven days courses for the treatment of.

Matched group: diseased region embrocates 2% aureomycin glycerine, 1% hydrogen peroxide rinsing the mouth, quiet of penicillin 8,000,000 U+ gentamycin 240,000 U+ dexamethasone 5mg, seven days courses for the treatment of.

1.4 efficacy assessment standards (1) clinical recovery: clinical symptoms, sign disappear, follows up a case by regular visits to 3 months without recurrence.(2) effective: symptom obviously alleviates.(3) effective: symptom alleviates slightly.(4) invalid: clinical symptoms, sign are without change.

I.5 statistical procedures uses SPSS 12.0 software to carry out statistical analysis, and ask that mean compares employing one factor analysis of variance for each group, group is asked and compared employing between two.Inspection.P<0.05 is that difference has significance.

2 results

Matched group recovery from illness 22 example, accounts for 44%; Effective 11 examples, account for 22%; Effective 8 examples, account for 16%; No effect 9, accounts for 18%, total effective rate 82%.Treatment group recovery from illness 98 example, accounts for 65.33%; Effective 32 examples, account for 21.33%; Effective 15 examples, account for 10%; Invalid 5 examples, account for 3.33%.Total effective rate accounts for 96.66%.Significance (P<O.05) is had through checking two groups of differences.

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims

1. treat a Chinese medicine preparation for viral pharyngitis, it is characterized in that, be made up of endo-medicine and external used medicine,

In described endo-medicine, the ratio of weight and number of various crude drug is: Herba Cardiospermi microcarpi 1.0-10 part, Herba Pileae Scriptae 1.0-10 part, Herba Asteris Ageratoidis 1.0-10 part, Herba Solidaginis 1.0-10 part, Radix Primulae sieboldii 1.0-10 part, Fructus Canarii albi 1.0-10 part, flower of Radix Notoginseng 1.0-10 part, Pulvis Fumi Carbonisatus 1.0-10 part, Radix Sophorae Tonkinensis 1.0-10 part, Caulis Clematidis Armandii 1.0-10 part, Herba Andrographis 1.0-10 part, Herba abutili indici 1.0-10 part, Herba Kalimeridis 1.0-10 part, Folium Momordicae 1.0-10 part, Herba Violae 0.5-5.0 part, Radix Scrophulariae 0.5-5.0 part, Cortex Phellodendri 0.5-5.0 part, fresh pears 0.5-5.0 part, Semen Ziziphi Spinosae 0.5-5.0 part, Fructus Lycii 0.5-5.0 part, Membrana Follicularis ovi 0.5-5.0 part, Herba Taraxaci 0.5-5.0 part, catechu 0.5-5.0 part, Flos Lonicerae 0.5-5.0 part, Flos Moutan 0.5-5.0 part,

In described external used medicine, the ratio of weight and number of various crude drug is: Herba Cardiospermi microcarpi 1.0-10 part, Herba Pileae Scriptae 1.0-10 part, Herba Asteris Ageratoidis 1.0-10 part, Herba Solidaginis 1.0-10 part, Radix Primulae sieboldii 1.0-10 part, Sanguis Draxonis 1.0-2.0 part, Indigo Naturalis 1.0-10 part, Calomelas 1.0-3.0 part, flower of Radix Notoginseng 1.0-10 part, Pulvis Fumi Carbonisatus 1.0-10 part, Radix Sophorae Tonkinensis 1.0-10 part, Caulis Clematidis Armandii 1.0-10 part, Herba Andrographis 1.0-10 part, Herba abutili indici 1.0-10 part, Herba Kalimeridis 1.0-10 part, Folium Momordicae 1.0-10 part, Herba Violae 0.5-5.0 part, Radix Scrophulariae 0.5-5.0 part, Cortex Phellodendri 0.5-5.0 part, Membrana Follicularis ovi 0.5-5.0 part, Herba Taraxaci 0.5-5.0 part, catechu 0.5-5.0 part, Flos Lonicerae 0.5-5.0 part, Flos Moutan 0.5-5.0 part.

2. a kind of Chinese medicine preparation for the treatment of viral pharyngitis according to claim 1, is characterized in that:

In described endo-medicine, the ratio of weight and number of various crude drug is: Herba Cardiospermi microcarpi 2.0-8.0 part, Herba Pileae Scriptae 2.0-8.0 part, Herba Asteris Ageratoidis 2.0-8.0 part, Herba Solidaginis 2.0-8.0 part, Radix Primulae sieboldii 2.0-8.0 part, Fructus Canarii albi 2.0-8.0 part, flower of Radix Notoginseng 2.0-8.0 part, Pulvis Fumi Carbonisatus 2.0-8.0 part, Radix Sophorae Tonkinensis 2.0-8.0 part, Caulis Clematidis Armandii 2.0-8.0 part, Herba Andrographis 2.0-8.0 part, Herba abutili indici 2.0-8.0 part, Herba Kalimeridis 2.0-8.0 part, Folium Momordicae 2.0-8.0 part, Herba Violae 1.0-3.0 part, Radix Scrophulariae 1.0-3.0 part, Cortex Phellodendri 1.0-3.0 part, fresh pears 1.0-3.0 part, Semen Ziziphi Spinosae 1.0-3.0 part, Fructus Lycii 1.0-3.0 part, Membrana Follicularis ovi 1.0-3.0 part, Herba Taraxaci 1.0-3.0 part, catechu 1.0-3.0 part, Flos Lonicerae 1.0-3.0 part, Flos Moutan 1.0-3.0 part,

In described external used medicine, the ratio of weight and number of various crude drug is: Herba Cardiospermi microcarpi 2.0-8.0 part, Herba Pileae Scriptae 2.0-8.0 part, Herba Asteris Ageratoidis 2.0-8.0 part, Herba Solidaginis 2.0-8.0 part, Radix Primulae sieboldii 2.0-8.0 part, Sanguis Draxonis 2.0-8.0 part, Indigo Naturalis 2.0-8.0 part, Calomelas 1.5-2.5 part, flower of Radix Notoginseng 2.0-8.0 part, Pulvis Fumi Carbonisatus 2.0-8.0 part, Radix Sophorae Tonkinensis 2.0-8.0 part, Caulis Clematidis Armandii 2.0-8.0 part, Herba Andrographis 2.0-8.0 part, Herba abutili indici 2.0-8.0 part, Herba Kalimeridis 2.0-8.0 part, Folium Momordicae 2.0-8.0 part, Herba Violae 1.0-3.0 part, Radix Scrophulariae 1.0-3.0 part, Cortex Phellodendri 1.0-3.0 part, Membrana Follicularis ovi 1.0-3.0 part, Herba Taraxaci 1.0-3.0 part, catechu 1.0-3.0 part, Flos Lonicerae 1.0-3.0 part, Flos Moutan 1.0-3.0 part.

3. a kind of Chinese medicine preparation for the treatment of viral pharyngitis according to claim 1, is characterized in that:

In described endo-medicine, the ratio of weight and number of various crude drug is: Herba Cardiospermi microcarpi 5.0 parts, Herba Pileae Scriptae 5.0 parts, Herba Asteris Ageratoidis 5.0 parts, Herba Solidaginis 5.0 parts, Radix Primulae sieboldii 5.0 parts, Fructus Canarii albi 5.0 parts, flower of Radix Notoginseng 5.0 parts, Pulvis Fumi Carbonisatus 5.0 parts, Radix Sophorae Tonkinensis 5.0 parts, Caulis Clematidis Armandii 5.0 parts, Herba Andrographis 5.0 parts, Herba abutili indici 5.0 parts, Herba Kalimeridis 5.0 parts, Folium Momordicae 5.0 parts, Herba Violae 2.0 parts, Radix Scrophulariae 2.0 parts, Cortex Phellodendri 2.0 parts, fresh pears 2.0 parts, Semen Ziziphi Spinosae 2.0 parts, Fructus Lycii 2.0 parts, Membrana Follicularis ovi 2.0 parts, Herba Taraxaci 2.0 parts, 2.0 parts, catechu, Flos Lonicerae 2.0 parts, Flos Moutan 2.0 parts,

In described external used medicine, the ratio of weight and number of various crude drug is: Herba Cardiospermi microcarpi 5.0 parts, Herba Pileae Scriptae 5.0 parts, Herba Asteris Ageratoidis 5.0 parts, Herba Solidaginis 5.0 parts, Radix Primulae sieboldii 5.0 parts, Sanguis Draxonis 5.0 parts, Indigo Naturalis 5.0 parts, Calomelas 2.0 parts, flower of Radix Notoginseng 5.0 parts, Pulvis Fumi Carbonisatus 5.0 parts, Radix Sophorae Tonkinensis 5.0 parts, Caulis Clematidis Armandii 5.0 parts, Herba Andrographis 5.0 parts, Herba abutili indici 5.0 parts, Herba Kalimeridis 5.0 parts, Folium Momordicae 5.0 parts, Herba Violae 2.0 parts, Radix Scrophulariae 2.0 parts, Cortex Phellodendri 2.0 parts, Membrana Follicularis ovi 2.0 parts, Herba Taraxaci 2.0 parts, 2.0 parts, catechu, Flos Lonicerae 2.0 parts, Flos Moutan 2.0 parts.

4. a kind of preparation method for the treatment of the Chinese medicine preparation of viral pharyngitis according to claim 1-3 any one, is characterized in that: the dosage form of described oral preparations is that sweet preparation method of refining pill comprises:

5. a kind of Chinese medicine preparation honey for the treatment of viral pharyngitis refines pill preparation method according to claim 4, it is characterized in that: in described step b, get the 60-90% soak with ethanol 1-2 hour that surplus stock medicine adds 5-10 times amount, heating extraction 2 times, each 1-2 hour, remove supernatant, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into pasty state, mass continues heating and is concentrated into extractum shape, stand for standby use, become component 1, in described step c, medicinal residues add 5-10 times amount water soaking 1-2 hour, within 1-1.5 hour, extract 1 time, as component 2.

6. a kind of preparation method for the treatment of the Chinese medicine preparation of viral pharyngitis according to claim 1-3 any one, is characterized in that: the form of Chinese drug of described oral preparations is that the preparation method of soup potus comprises:

7. a kind of preparation method for the treatment of the Chinese medicine preparation of viral pharyngitis according to claim 1-3 any one, is characterized in that: the form of Chinese drug of described oral preparations is that the preparation method of capsule comprises:

A, all crude drug are put into ethanol heating and refluxing extraction;

B, again by medicinal residues water heating and refluxing extraction;

8. a kind of capsule preparation method thereof for the treatment of the Chinese medicine preparation of viral pharyngitis according to claim 7, it is characterized in that: in described step a, raw medicinal material can be put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extract active ingredient, 2 extracting solution are merged filtering and standing; In described step b, the medicinal residues refined can be put into 10 times of water gagings, heating and refluxing extraction 3 times, each 45 minutes ~ 1 hour, 3 extracting solution be merged, filtering and standing;

9. a kind of preparation method for the treatment of the Chinese medicine preparation of viral pharyngitis according to claim 1-3 any one, is characterized in that: the form of Chinese drug of described external medicine preparation is that the preparation method of collutory comprises:

10. a kind of preparation method for the treatment of the Chinese medicine preparation of viral pharyngitis according to claim 1-3 any one, is characterized in that: the form of Chinese drug of described endo-medicine preparation is that the preparation method of buccal tablet comprises: