CN1302655A - Compound broadleaf holly leaf buccal tablet and preparation method thereof - Google Patents
Compound broadleaf holly leaf buccal tablet and preparation method thereof Download PDFInfo
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- CN1302655A CN1302655A CN 00136398 CN00136398A CN1302655A CN 1302655 A CN1302655 A CN 1302655A CN 00136398 CN00136398 CN 00136398 CN 00136398 A CN00136398 A CN 00136398A CN 1302655 A CN1302655 A CN 1302655A
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The compound buccal lozenge of broadleaf holly leaf is prepared with broadleaf holly leaf, honeysuckle, subprostrate sophora root, figwort root, licorice, etc. and through crushing, water extraction, alcohol precipitation, pelletizing and tabletting.
Description
The present invention relates to a kind of buccal tablet,, extract health care buccal tablets of active ingredient and preparation method thereof in the natural plants such as Flos Lonicerae particularly from Folium Ilicis with health care.
Present compound buccal lozenge both domestic and external is more, domestic most of buccal tablet also all adopts from natural plants and to extract active ingredient and make, Herba Pileae Scriptae Tabellae for example, watermelon crystal buccal tablet, JINSANGZIHOUBAO, king Lao Ji buccal tablet, traditional Chinese herbal medicine formula of these folks of china that are selected all obtains through processing, some buccal tablet both can be used as expelling summer-heat sugar-tablet or chewing gum in summer, also can be used as the medicament of heat-clearing and toxic substances removing, in order to the treatment pharyngitis, tonsillitis, bronchitis, to the performer, the announcer, the clear and rich throat of teacher also plays better effect, to drinking, the throat pain curative effect that smoking etc. cause is also good.Except the health care buccal tablets or Chinese herbal medicine buccal tablet of shop, pharmacy's public offering, open source literature reported also that some with the content of natural plants as health beverage or heat-clearing and toxic substances removing tablet, disclosed the concentrated health-care liquor that contains Radix Polygoni Multiflori, Radix Actinodaphnes Cupularis, Folium Ilicis, Flos Lonicerae, Folium Ginkgo, Flos Jasmini Sambac extraction as No. 95107874 Chinese patents; Chinese patent 99114920 also disclose a kind of by Chinese medicines such as Herba Menthae, Radix Platycodonis, Folium Ilicis, Radix Glycyrrhizae, green tea, Flos lupuli (Flos Humuli Lupuli), Flos Lonicerae be raw material make quench the thirst, relieve summer heat, the antipyretic beverage.
See that from above-mentioned disclosed patent documentation Chinese herbal medicine buccal tablet that has or beverage composition are complicated, the function singleness that has, the preparation process operation that has is more, active ingredient is extracted not exclusively, have make buccal tablet after get damp easily, carry or preserve to people and bring inconvenience.
The purpose of this invention is to provide and a kind ofly from natural plants such as Folium Ilicis, Flos Lonicerae, Radix Sophorae Tonkinensis, extract active ingredient, make and not only can be used as chewing gum, larynx moistening candy, but also can be used as medicinally, have the compound buccal lozenge of lectuce tea of heat-clearing and toxic substances removing, antiphlogistic antibacterial.
Purpose of the present invention also provides a kind of manufacturing process simple, and it is complete to extract active ingredient, makes buccal tablet and preserves easily and carry, and is difficult for the preparation method of the Folium Ilicis compound buccal lozenge that moisture absorption gets damp.
The inventor is from the Chinese Plants handbook and among the peoplely recognize that many natural plants have eliminating inflammation and expelling toxin, resolving heat and reducing pathogenic fire effect preferably, plants such as Folium Ilicis, Flos Lonicerae, Radix Sophorae Tonkinensis, Radix Helicteris, Rhizoma Imperatae, Herba Hyperici Japonici for example, we ancestors just are used for enduring the inflammation of diseases caused by retention of fluid clothes treatment throat before the two thousand years, commonly encountered diseases such as the intestines and stomach heat symptom-complex, many hill farmers also use it as tea or electuary drink-service for a long time, and it plays liver heat removing function of gallbladder promoting, refreshment, pathogenic fire reducing and goes effects such as acute diseases such as cholera and sunstroke.At present, southern urbanite also usually makes tea these plants, strengthens its health care.The inventor takes through a large amount of scientific experiments and examinations, selected several natural plants, therefrom extract active ingredient, it is made contain tablet, finding has effect to the oral cavity antiphlogistic antibacterial after many people use these buccal tablets, and tonsil, respiratory inflammation etc. is had curative effect preferably, also has the effect of refreshment, blood fat-reducing blood pressure-decreasing, liver heat removing function of gallbladder promoting, the inventor has adopted following several plant as containing tablet raw material, its quality percentage composition following (in dry material) after screening:
Folium Ilicis 10-20, Flos Lonicerae 15-30, Radix Scrophulariae 8-20,
Radix Sophorae Tonkinensis 10-20, Radix Glycyrrhizae 5-15, Mentholum 0.1-0.5,
The preparation method of compound buccal lozenge of lectuce tea of the present invention comprises that mainly raw material pulverizing, water reflux, extract,, the dried cream of ethanol precipitation system, adding sucrose and sweeting agent mix technological processes such as method for making, drying, tabletting, packing, and concrete manufacture method is as follows:
Earlier with above-mentioned raw material coarse pulverization except that Mentholum to particle diameter≤3 millimeter (available wet feed material, the also bright raw material of available firm harvesting);
2. add 8-10 times of water reflux, extract, 1-2 time, each 1-3 hour, the thick slag of elimination;
3. the water extract is concentrated into the 1/30-1/40 of amount of water, the ethanol that adds 70-80% (mass fraction) precipitates, and amount of alcohol added is 5-6 a times of concentrated solution, sedimentation time is 1-2 hour, filters, and filtrate repetition is precipitated 2-3 time, concentrate as for paste at last, and reclaim ethanol.
4. account for 20% by dried cream, add Mentholum 0.1-0.5%, sucrose 50-60%, sweeting agent, as the sweetener 1-2% of Aspartame (Aspartame), glycosides, stevioside, mogroside or other plant extract, starch 10-15% prepares burden.At first Mentholum is joined in the dried cream, add the ethanol moistening of an amount of 70-80% after, drop into all the other components mixing granulation in granulator;
5. expected 16 mesh sieves, in 60-65 ℃ of dry 2-3 hour;
6. in the good granule of drying, add 1% surface lubricant by gross mass, as magnesium stearate, calcium stearate, mix homogeneously, tabletting is made the buccal tablet of every 1-1.5 gram, and every agreement that contracts a film or TV play to an actor or actress contains dried cream 0.2-0.3 gram, is packaged to be product then.
The below performance and the effect of each plant component of summary:
Folium Ilicis has another name called Fu Dingcha, hardship is stepped on tea, and main product is in Guangdong and Guangxi Provinces, and this tea set has multiple treatment and health function, the medicated tea dual-purpose, be China treasure the Traditional health care well-known tea, in existing more than the 2000 year history of folklore.Folium Ilicis sweet-bitter flavor, cold in nature has resolving heat and reducing pathogenic fire, inhibiting bacteria and diminishing inflammation, the refreshment of refreshing oneself, blood fat-reducing blood pressure-decreasing, removes multiple pharmacological effect and health-care effect such as the sharp larynx of acute diseases such as cholera and sunstroke.The active ingredient of Flos Lonicerae is chlorogenic acid and volatile oil, has effects such as heat-clearing and toxic substances removing, bactericidal antiphlogistic, function of gallbladder promoting, and Flos Lonicerae can combine with cholesterol, thereby can reduce the absorption of intestinal and cholesterol.Be usually used in treating diseases such as upper respiratory tract infection, tonsillitis, pharyngitis, bronchitis clinically.Radix Sophorae Tonkinensis is a Guangxi special product wild plant, function cure mainly for relieve inflammation or internal heat, detoxify, detumescence, pain relieving, can soothe sore throat, acute throat trouble, gingival swelling and pain, jaundice, heat are swollen etc., many institutes of materia medica carried out research to its pharmacology, found that it has multiple efficacies.Radix Scrophulariae, diseases such as energy YIN nourishing, pathogenic fire reducing, relieving restlessness, detoxifcation, laryngopharynx swelling and pain.Herba Menthae, Radix Glycyrrhizae are refrigerant and assosting effect, can strengthen curative effect and make mouthfeel better.Above-mentioned several natural plants is used together, and is refining through the science compatibility, more can bring into play function separately.
Folium Ilicis compound buccal lozenge of the present invention has adopted water to carry-method of ethanol precipitation impurity, has improved content of effective, and raw material and tablet formulation science are fastidious, thereby obtain high-quality Folium Ilicis compound buccal lozenge.
The present invention has the following advantages:
1. owing to adopted water to carry-method of ethanol precipitation, removed most of impurity, as protein, starch, phlegmatic temperament, fat-soluble pigment, resin etc., tannin also can be removed major part.The middle active constituent content that gets dry extract is improved.
2. the Folium Ilicis compound buccal lozenge of the present invention's preparation has following health care:
1. effects of antiinflammation and bacteriostasis
This product all has inhibitory action to staphylococcus aureus, Staphylococcus albus, Bacillus typhi, first type, beta hemolytic streptococcus etc.
2. treat periodontitis, pharyngolaryngitis
Clinical practice proves that Flos Lonicerae, Herba Lactucae formosanae tea extract all have fine therapeutical effect to periodontitis, gingivitis, stomatitis, pharyngolaryngitis etc.
3. blood fat reducing, hypotensive effect
The present invention is further illustrated below in conjunction with following embodiment:
Embodiment 1:
Folium Ilicis 2kg, Flos Lonicerae 3kg, Radix Scrophulariae 2kg, Radix Sophorae Tonkinensis 2kg, Radix Glycyrrhizae 1kg is 10kg altogether, suitably is ground into the particulate less than 3 millimeters, add 10 times of amount 100kg distilled water then and keep little reflux, extract, 3 hours of boiling, cold filtration, filtering residue add 8 times of amount distilled water 800kg to be brought up again 2 hours.Merging filtrate is concentrated into about 6L, slowly adds 70% ethanol 30L, notes stirring while adding, and leaves standstill, and filters.Filtrate is concentrated into syrupy shape and reclaims ethanol, adds 75% ethanol 30L for the second time, repeats last time to operate.Add 80% ethanol 30L for the third time, repeat last time to operate, be concentrated into dried paste at last, and reclaim ethanol.Carry out the batching of tablet by dried cream 2kg.Add the 0.015kg Mentholum, dissolve with 80% ethanol 500ml, the sucrose that adds 6.4kg successively, 1.4kg starch and aspartame or other plant sweetener of 0.185kg carry out mixing granulation, granule is crossed 16 mesh sieves, and drying is 3 hours about 60 ℃, with 14 orders and 80 mesh sieve granulate, add the magnesium stearate mixing of granular mass 1%, carry out tabletting by every 1g.Every contains dried cream 0.2g.
Embodiment 2:
Folium Ilicis 4kg, Flos Lonicerae 6kg, Radix Scrophulariae 4kg, Radix Sophorae Tonkinensis 4kg, Radix Glycyrrhizae 2kg is 20kg altogether, suitably is ground into the particulate less than 3 millimeters, add 10 times of amount 200kg distilled water then and keep little reflux, extract, 3 hours of boiling, cold filtration, filtering residue add 9 times of amount distilled water 180kg to be brought up again 1.5 hours.Merging filtrate.Filtrate is concentrated into syrupy shape and reclaims ethanol, adds 78% ethanol 65L for the second time, repeats last time to operate.Be concentrated into dried paste at last, and reclaim ethanol.Carry out the batching of tablet by dried cream 4kg.Add the 0.03kg Mentholum, separate with 80% ethanol 1000ml shallow lake, the sucrose that adds 13kg successively, 2.57kg starch and the aspartame of 0.4kg carry out mixing granulation, granule is crossed 16 mesh sieves, and drying is 3 hours about 60 ℃, with 14 orders and 80 mesh sieve granulate, add the magnesium stearate mixing of granular mass 1%, carry out tabletting by every 1g.Every contains dried cream 0.2g.
Claims (9)
1. compound buccal lozenge of lectuce tea adopts natural plants such as Folium Ilicis, Flos Lonicerae, Radix Scrophulariae, Radix Sophorae Tonkinensis as primary raw material and extract its active ingredient and make, and it is characterized in that its raw material composition and quality percentage composition are:
Folium Ilicis 10-20, Flos Lonicerae 15-30, Radix Scrophulariae 8-20,
Radix Sophorae Tonkinensis 10-20, Mentholum 0.1-0.5, Radix Glycyrrhizae 5-15.
2. the preparation method of the described compound buccal lozenge of lectuce tea of claim 1, it is characterized in that comprising raw material pulverizing, water reflux, extract,, the dried cream of ethanol precipitation system, add the processing step of sucrose and sweetener mixing granulation, drying, tabletting, packing.
3. the preparation method of compound buccal lozenge of lectuce tea according to claim 2 is characterized in that the process of raw material pulverizing is: the particle that Folium Ilicis, Flos Lonicerae, Radix Scrophulariae, Radix Sophorae Tonkinensis, Radix Glycyrrhizae powder is broken to diameter≤3 millimeter;
4. the preparation method of compound buccal lozenge of lectuce tea according to claim 2 is characterized in that water reflux, extract, process is to add 8-10 times of water reflux, extract, 1-2 time in the raw material of pulverizing, each 1-3 hour, and the thick slag of elimination;
5. the preparation method of compound buccal lozenge of lectuce tea according to claim 2, the process that it is characterized in that the dried cream of ethanol precipitation system is the 1/30-1/40 that the water extract is concentrated into amount of water, the ethanol that adds mass fraction 70-80% precipitates, amount of alcohol added is 5-6 a times of concentrated solution, sedimentation time is 1-2 hour, filtrate repetition is precipitated 2-3 time, is concentrated into dried paste at last, and reclaims ethanol.
6. the preparation method of compound buccal lozenge of lectuce tea according to claim 2; the process that it is characterized in that adding sucrose and sweetener mixing granulation is to account for 20% by dried cream; add Mentholum 0.1-0.5%, sucrose 50-60%; sweeting agent 1-2%; starch 10-15% prepares burden; earlier Mentholum is joined in the dried cream, add the ethanol moistening of 70-80% after, drop into all the other components and in granulator, granulate.
7. the preparation method of compound buccal lozenge of lectuce tea according to claim 2 is characterized in that dry run is that granule is crossed 16 mesh sieves, in 60-65 ℃ of dry 2-3 hour.
8. the preparation method of compound buccal lozenge of lectuce tea according to claim 2, the process that it is characterized in that tabletting are that the surface lubricant that adds in the good granule of drying by gross mass 1% mixes, and tabletting obtains product.
9. the preparation method of compound buccal lozenge of lectuce tea according to claim 2 is characterized in that the sweetener that adds is the sweetener of Aspartame, glycosides, stevioside, mogroside or other plant extract.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 00136398 CN1225251C (en) | 2000-12-29 | 2000-12-29 | Compound broadleaf holly leaf buccal tablet and preparation method thereof |
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| CN 00136398 CN1225251C (en) | 2000-12-29 | 2000-12-29 | Compound broadleaf holly leaf buccal tablet and preparation method thereof |
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| CN1302655A true CN1302655A (en) | 2001-07-11 |
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Cited By (8)
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| CN1328967C (en) * | 2005-03-09 | 2007-08-01 | 陕西科技大学 | Tea buccal tablet and its manufacturing method |
| CN102273537A (en) * | 2011-08-26 | 2011-12-14 | 宁国市亿邦生物科技有限公司 | Litsea Coreana leve. Var. effervescent tablets and preparation method thereof |
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| CN103843926A (en) * | 2014-02-11 | 2014-06-11 | 毛庆云 | Sugar-free broadleaf holly leaf buccal tablet and preparation method thereof |
| CN104383232A (en) * | 2014-12-03 | 2015-03-04 | 大新县科学技术情报研究所 | Broadleaf holly leaf lozenge with effects of clearing away heat and toxic materials and production method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1328967C (en) * | 2005-03-09 | 2007-08-01 | 陕西科技大学 | Tea buccal tablet and its manufacturing method |
| CN102273537A (en) * | 2011-08-26 | 2011-12-14 | 宁国市亿邦生物科技有限公司 | Litsea Coreana leve. Var. effervescent tablets and preparation method thereof |
| CN102273537B (en) * | 2011-08-26 | 2013-03-20 | 宁国市亿邦生物科技有限公司 | Litsea Coreana leve. Var. effervescent tablets and preparation method thereof |
| CN103751814A (en) * | 2014-01-02 | 2014-04-30 | 上海原子科兴药业有限公司 | Method for preparing technetium (99mTc) methylene diphosphonate injection medicament with long effective period |
| CN103751814B (en) * | 2014-01-02 | 2015-10-28 | 上海原子科兴药业有限公司 | Prepare long effect duration technetium [ 99mtc] method of methylene diphosphonate injection medicine |
| CN103843926A (en) * | 2014-02-11 | 2014-06-11 | 毛庆云 | Sugar-free broadleaf holly leaf buccal tablet and preparation method thereof |
| CN104383232A (en) * | 2014-12-03 | 2015-03-04 | 大新县科学技术情报研究所 | Broadleaf holly leaf lozenge with effects of clearing away heat and toxic materials and production method thereof |
| CN104383232B (en) * | 2014-12-03 | 2018-06-05 | 大新县科学技术情报研究所 | Clearing heat and detoxicating buccal lozenge of lectuce tea and its production method |
| CN104587078A (en) * | 2015-02-12 | 2015-05-06 | 南艳子 | Traditional Chinese medicine preparation for treating viral pharyngitis |
| CN109349399A (en) * | 2018-08-30 | 2019-02-19 | 阜阳健诺生物科技有限公司 | A kind of candy and preparation method thereof improving canker sore |
| CN110151713A (en) * | 2019-05-22 | 2019-08-23 | 苏州知时生物科技有限公司 | Plant oral mucosa fibrosis chewable tablets and preparation method thereof |
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| CN1225251C (en) | 2005-11-02 |
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