CN100402073C - Medicine for treating disease caused by heat toxin - Google Patents
Medicine for treating disease caused by heat toxin Download PDFInfo
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- CN100402073C CN100402073C CNB2005100639783A CN200510063978A CN100402073C CN 100402073 C CN100402073 C CN 100402073C CN B2005100639783 A CNB2005100639783 A CN B2005100639783A CN 200510063978 A CN200510063978 A CN 200510063978A CN 100402073 C CN100402073 C CN 100402073C
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Abstract
The present invention discloses a medicine for treating diseases caused by heat toxin. The present invention belongs to the technical field of medicine, and particularly, relates to a Chinese patent medicine used for treating diseases caused by heat toxin of parotitis, quinsy, laryngitis, ulcerative carbuncle, pyogenic infection, upper respiratory tract infection, etc., and prepared by using Chinese medicines with the main components of paris rhizome, southern isatis root, borneol, dandelion, liquorice, etc. The medicine is prepared by scientifically screening and formula simplification according to the Chinese medicine and pharmacy theory and clinical test results; capsules and tablets are prepared by using a modern advanced production process; the present invention solves the problems of numerous and jumbled prescription, large dosage, no strong pertinence of treating syndrome type, inconspicuous therapeutic effect, no strong operability of the production process, unstable quality, etc. The problems exist in the similar products. The medicine has the efficiency of clearing away the heat-evil and expelling superficial evils, removing stasis and detumescence, and is used for treating the diseases of parotitis, quinsy, laryngitis, ulcerative carbuncle, pyogenic infection, upper respiratory tract infection, etc., which are caused by heat toxin.
Description
One, technical field
The invention belongs to medical technical field, particularly relate to the Chinese patent medicine that utilizes Main Ingredients and Appearance to be used for the treatment of diseases such as parotitis due to the dominance of heat in the interior, tonsillitis, laryngitis, carbuncle pyogenic infections from tumour or sore, upper respiratory tract infection for Chinese medicines such as Rhizoma Paridis, Rhizoma Et Radix Baphicacanthis Cusiae, Borneolum Syntheticum, Herba Taraxaci, Radix Glycyrrhizae prepare.The invention still further relates to the preparation method of this medicine.
Two, background technology
Dominance of heat in the interior disease such as parotitis, tonsillitis, laryngitis, carbuncle pyogenic infections from tumour or sore, upper respiratory tract infection extremely be commonly encountered diseases, frequently-occurring disease, the sickness rate height, the serious harm people's is healthy.Statistics shows that the parotitis sickness rate reaches 5～10% in the Susceptible population; The laryngitis sickness rate is 7～15%, and the tonsillitis sickness rate is up to 15～30%.The medicine that is used for the treatment of this type of disease at present is many, but does not see to have and utilize Rhizoma Paridis, Rhizoma Et Radix Baphicacanthis Cusiae, Borneolum Syntheticum, Herba Taraxaci, Radix Glycyrrhizae prescription to prepare the medicine that can be used for above-mentioned disease.The oral Chinese patent medicine that is used for the treatment of this type of disease on the market has: contribution reduce internal heat sheet, Waterelon Frost Lozenges, material for anti parotitis sheet, antivirus oral liquid etc., Chinese Pharmacopoeia all records.The chemistry medicine mainly is some antibioticses, and kind is a lot.Because the side effect of chemical medicine is big, life-time service can produce drug resistance, and the infection that virus is caused is invalid.So up to now, Chinese medicine still plays very important effect.The tradition traditional Chinese medical science utilizes Herba Taraxaci prescription therapeutic pyretic toxicity card with a long history, record many Chinese medicinal formulaes, but these Chinese medicine prescriptions are often all very huge, shortcoming such as have that dose is big, the pattern of syndrome specific aim of treatment is strong, complex process, cost height, curative effect are not fully up to expectations.
In recent years, Chinese patent also discloses some treatment pharyngolaryngitis, tonsillitic medicine, is made up of flavour of a drug such as Thalictrum aquilegifolium L. var. sibiricum Regel, Rhizoma Paridis, Rhizoma Belamcandae, Calyx seu Fructus physalis, Cortex cercis chinensiss as 031111769 disclosed " a kind of treatment acute pharyngitis, laryngitis, tonsillitic medicine and preparation method thereof "; 021002983 disclosed " a kind of medicine for the treatment of tonsillitis, pharyngolaryngitis " is made up of 17 flavor Chinese medicines such as Fructus Canarii, Rhizoma Paridis, Borneolum Syntheticum, Radix Glycyrrhizae, and 971043469 disclosed " a kind of medicines for the treatment of acute tonsillitis and upper respiratory tract infection and preparation method thereof " are made up of flavour of a drug such as Periostracum Cicadae, Bombyx Batryticatus, Rhizoma Curcumae Longae, Radix Et Rhizoma Rhei, Herba Menthae, Radix Scrophulariaes.The one-tenth that above-mentioned these medicines have is grouped into too numerous and diverse, and what have is not that therapeutic domain is too narrow again at the pyretic toxicity card.The prescription that has and method for making are incompatible to be produced in batches, does not also meet " the medicine registration management way " of State Food and Drug Administration's promulgation regulation about the new Chinese medicine registration, is difficult to obtain to produce certificate, thereby promotes the use of and be subjected to certain limitation.
Three, summary of the invention
The purpose of this invention is to provide that a kind of prescription is succinctly reasonable, with strong points, determined curative effect, moderate cost, be used for the treatment of dominance of heat in the interior the Chinese patent medicine of disease such as parotitis, tonsillitis, laryngitis, carbuncle pyogenic infections from tumour or sore, upper respiratory tract infection extremely.
Another object of the present invention provides the preparation method of this medicine.The present invention is to be guidance with the theory of Chinese medical science, according to for many years clinical experience numerous similar prescriptions are compared research, therefrom selected osmanthus, Guizhou Province, the Yunnan special product herbal prescription that shows unique characteristics forms, and confirms the reasonability of its effectiveness, safety and prescription and the feasibility of production technology through pharmacodynamics, toxicology and clinical trial.Its main component percentage by weight is as follows:
Rhizoma Paridis fine powder 20～60; Rhizoma Et Radix Baphicacanthis Cusiae coarse powder 15～35; Radix Glycyrrhizae 5～15; Herba Taraxaci 15～35; Borneolum Syntheticum (porphyrize 0.2～1
Preparing optimum weight portion proportioning of the present invention is:
Rhizoma Paridis fine powder 33; Rhizoma Et Radix Baphicacanthis Cusiae coarse powder 28.5; Radix Glycyrrhizae 9.5; Herba Taraxaci 28.5; Borneolum Syntheticum (porphyrize) 0.5 preparation method of the present invention is:
1, get Rhizoma Et Radix Baphicacanthis Cusiae and add 65%～95% alcohol reflux 2 times, each ethanol consumption is 3～8 times, and 3 hours for the first time, 2 hours for the second time, merge extractive liquid, filtered, and was condensed into thick paste A behind the recovery ethanol;
2, Rhizoma Et Radix Baphicacanthis Cusiae medicinal residues and Radix Glycyrrhizae, the Herba Taraxaci of fetching behind the stream decocts with water 3 times together, first and second time each 2 hours, and 0.5 hour for the third time, collecting decoction filtered, and filtrate is condensed into thick paste B.
3, thick paste A and thick paste B mix homogeneously add starch and bake dried cream in right amount, are ground into to add Rhizoma Paridis fine powder mixing behind the fine powder and get intermediate products C.
4, add Borneolum Syntheticum among the intermediate products C, make tablet and capsule by the conventional processing method adding appropriate amount of auxiliary materials of each dosage form again.
The used raw material of the present invention all derives from the version Pharmacopoeia of the People's Republic of China in 2005.Be set forth as follows with regard to the mechanism of curing the disease of the present invention according to theory of Chinese medical science and modern study result:
The Rhizoma Paridis beginning is stated from " herbal classic " in the side, and its nature and flavor hardship is slightly cold, the merit of tool heat-clearing and toxic substances removing, detumescence dissipating blood stasis.The Rhizoma Paridis hardship is rushed down removing heat from blood, and the energy removing summer-heat is hot and suffocating, and subduing inflammation is the key medicine of furuncle swelling toxin.All all furuncle swelling toxins, various cancerous protuberances, laryngopharynx swelling and pain, oral administration and externally all can be used.Rhizoma Paridis has strong inhibitory action to the Asia influenza A virus, dysentery bacterium, Salmonella paratyphi, Salmonella, paracolon, pseudomonas aeruginosa, meningococcus, staphylococcus aureus are all had certain inhibitory action, and 1998 the 20th the 4th phases of volume of " national Chinese herbal medicine compilation " first volume and " China Medicine University's journal " are all on the books.Rhizoma Et Radix Baphicacanthis Cusiae, the another name Herba Kalimeridis, the beginning is stated from supplement to the Herbal, and is pungent in flavor and cool in property, has removing heat from blood, heat clearing away, dampness removing, the merit of detoxifcation is applicable to haematemesis, edema, pharyngalgia, the larynx fraud, carbuncle, erysipelas etc., the successive dynasties medicine man and document its effect is all had detailed argumentation: " medical secrets of official ": " controlling the larynx fraud "; " book on Chinese herbal medicine justice ": " Herba Kalimeridis is separated pyretic toxicity most, can specially go into blood system, and all warm heresy deeply battalion are divided, and the carbuncle and ulcer heat in blood, and cards such as decomposed fairly are special medicine, Orally taken and externally, it uses very wide, also heat-clearing and toxic substances removing will product also "." Jiangxi traditional herbal medicine ": " controlling laryngopharynx swelling and pain "; " Yunnan Chinese herbal medicine ": " remove wind, dissipating cold, relieving cough and asthma.Control bronchitis ".The Herba Taraxaci beginning is stated from " Newly Revised Canon of Materia Medica ", and bitter but sweet flavor is cold in nature, is longer than heat-clearing and toxic substances removing, and mass dissipating and swelling eliminating, and the gas that stagnates that can loose are so be usually used in the carbuncle furunculosis.Because of kind heat-clearing and toxic substances removing, also be usually used in inflammation of upper respiratory tract etc.Modern pharmacological research shows that Herba Taraxaci all has inhibitory action in various degree to staphylococcus, staphylococcus aureus and various skin fungus.The use of Radix Glycyrrhizae is with a long history, and its property is little sweet light, goes into the heart, lung meridian.Not only had the merit of invigorating the spleen and replenishing QI, expelling phlegm for arresting cough, heat-clearing and toxic substances removing but also can play the effect of coordinating the actions of various ingredients in a prescription.Be usually used in carbuncle pyogenic infections from tumour or sore, laryngopharynx swelling and pain and various nosotoxicosis.In traditional compound preparation, Radix Glycyrrhizae commonly used is lowered or the bias and the toxicity of cushion.It is the adjuvant of using always.Borneolum Syntheticum beginning is stated from " not record ", hot, hardship, is slightly cold.Have the refreshment of having one's ideas straightened out, heat radiation analgesic effect.Be applicable to that laryngopharynx swelling and pain, oral ulcer, furunculosis swell and ache etc.Pharmacological research shows that staphylococcus aureus, escherichia coli growth are had inhibitory action.More than all medicines share, play the effect of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds altogether.Be applicable to the treatment dominance of heat in the interior diseases such as parotitis, tonsillitis, laryngitis, upper respiratory tract infection extremely.
Compared with the prior art, the present invention has following characteristics and advantage:
1, utilize the Guangxi herb resource, the medicine source is rich and easy to get, and cost is low.
2, prescription science of the present invention, succinct, reasonable.To because of the side of plan, compatibility is proper, has both solved the overweight fraud of like product prescription component, meets " getting effect with light diaphoretic prescription " this Traditional Chinese medical theory again.
3, it is with strong points that the present invention treats disease spectrum, is exclusively used in the disease due to the treatment dominance of heat in the interior, and effect is remarkable.Can be used for parotitis, tonsillitis, laryngitis, also can be used for upper respiratory tract infection.Through 528 routine clinical trials, statistical result shows: treatment parotitis 70 examples, wherein cure 27 examples, and account for 38.5%, produce effects 31 examples account for 44.3%, and effective 10 examples account for 14.3%, and invalid 2 examples account for 2.8%, total effective rate 97.1%.Treatment tonsillitis 57 examples are cured 11 examples and account for 19.3% its near-mid terms, and produce effects 29 examples account for 50.1%, and effective 15 examples account for 24.6%, and invalid 2 examples account for 3.5%, total effective rate 96.5%.Treatment laryngitis 109 examples, cure 38 examples its near-mid term, accounts for 34.9%, and produce effects 59 examples account for 54.1%, and effective 9 examples account for 8.3%, and invalid 3 examples account for 2.8%, total effective rate 97.3%.It is oral to press therapeutic dose, does not find any untoward reaction, illustrates that thus the present invention is clinical safe in utilization effective.Pharmacological evaluation proves: the present invention has stronger inhibitory action to virus, and antimicrobial spectrum is wider, and various antibacterials such as dysentery bacterium, escherichia coli, Bacillus typhi, Salmonella paratyphi, staphylococcus aureus, Hemolytic streptococcus, meningococcus etc. are all had inhibitory action.Gelatin is caused that rat paw edema has obvious inhibitory action, can obviously suppress to cause that by histamine the rat capillary permeability increases, also can suppress the effect with leukoplania of oozing out of rat hydrothorax that acetic acid causes.Illustrate that it has good antiinflammatory action.Irritate stomach mice accumulation clearly with pyretic toxicity and reach 24g/kg, observe after 7 days, do not see untoward reaction, the no abnormal change of each internal organs.The rat sub-acute toxicity test shows, with 1.08g/kg, 4.02g/kg (is equivalent to 13 times of people's clinical dosage, 50 times) continuously gastric infusion observed 15 days, the every vital sign of rat, liver, renal function are normal, and important organ is checked through pathological section, and avirulence changes and the retardance toxic reaction.
4, the production technology advanced person is workable, is fit to suitability for industrialized production; Finished product active constituent content height.
5, constant product quality is controlled.According to the effective ingredient and the national requirement of raw material in the prescription to preparation, adopt modern advanced detection technique, formulated the quality standard of product, meet modernization of Chinese medicine requirement.
Four. the specific embodiment
Embodiment one:
1, get Rhizoma Et Radix Baphicacanthis Cusiae coarse powder 120g and add 70% alcohol reflux 2 times, 3 hours for the first time, 2 hours for the second time, the ethanol consumption was respectively 7 times, 5 times.Merge extractive liquid, filters, and is condensed into thick paste A behind the recovery ethanol;
2, Rhizoma Et Radix Baphicacanthis Cusiae medicinal residues and Radix Glycyrrhizae 40g, the Herba Taraxaci 120g that fetches behind the stream decocts with water 3 times together, first and second time each 2 hours, and 0.5 hour for the third time, collecting decoction filtered, and filtrate is condensed into thick paste B.
3, thick paste A and thick paste B mix homogeneously add starch and bake dried cream in right amount, are ground into to add Rhizoma Paridis fine powder 140g mixing behind the fine powder and get intermediate products C.
4, with intermediate products C, add the Pulvis Talci of Borneolum Syntheticum 2g and adding 2%, mixing incapsulates promptly.
Embodiment two:
1, get Rhizoma Et Radix Baphicacanthis Cusiae coarse powder 200g and add 95% alcohol reflux 2 times, 3 hours for the first time, 2 hours for the second time, each ethanol consumption was 6 times.Merge extractive liquid, filters, and is condensed into thick paste A behind the recovery ethanol;
2, Rhizoma Et Radix Baphicacanthis Cusiae medicinal residues and Radix Glycyrrhizae 50g, the Herba Taraxaci 200g that fetches behind the stream decocts with water 3 times together, first and second time each 2 hours, and 0.5 hour for the third time, collecting decoction filtered, and filtrate is condensed into thick paste B.
3, thick paste A and thick paste B mix homogeneously add starch and bake dried cream in right amount, are ground into to add Rhizoma Paridis fine powder 560g mixing behind the fine powder and get intermediate products C.
4, with intermediate products C, add appropriate amount of auxiliary materials and make 14～40 purpose granules, dry back adds magnesium stearate mixing tabletting that Borneolum Syntheticum 5g mixing adds granule total amount 0.2% again promptly.
Claims (3)
1. a medicine for the treatment of parotitis due to the dominance of heat in the interior, tonsillitis, laryngitis, carbuncle pyogenic infections from tumour or sore, upper respiratory tract infection is characterized in that it is to be made by the activated feedstock of following weight parts proportioning: Rhizoma Paridis fine powder 20～60; Rhizoma Et Radix Baphicacanthis Cusiae coarse powder 15～35; Radix Glycyrrhizae 5～15; Herba Taraxaci 15～35; The Borneolum Syntheticum 0.2～1 of porphyrize.
2. a kind of medicine for the treatment of parotitis due to the dominance of heat in the interior, tonsillitis, laryngitis, carbuncle pyogenic infections from tumour or sore, upper respiratory tract infection according to claim 1, it is characterized in that: wherein the weight portion proportioning of each activated feedstock is: Rhizoma Paridis fine powder 33; Rhizoma Et Radix Baphicacanthis Cusiae coarse powder 28.5; Radix Glycyrrhizae 9.5; Herba Taraxaci 28.5; The Borneolum Syntheticum 0.5 of porphyrize.
3. according to any one described a kind of preparation method for the treatment of the medicine of parotitis due to the dominance of heat in the interior, tonsillitis, laryngitis, upper respiratory tract infection in claim 1 and 2, it is characterized in that:
(1), get Rhizoma Et Radix Baphicacanthis Cusiae and add 65%～95% alcohol reflux 2 times, each ethanol consumption is 3～8 times, 3 hours for the first time, 2 hours for the second time, merge extractive liquid, filtered, and was condensed into thick paste A after reclaiming ethanol;
(2), Rhizoma Et Radix Baphicacanthis Cusiae medicinal residues and Radix Glycyrrhizae, the Herba Taraxaci fetched behind the stream decoct with water 3 times together, first and second time each 2 hours, 0.5 hour for the third time, collecting decoction filtered, filtrate is condensed into thick paste B;
(3), that thick paste A and thick paste B mix homogeneously add starch is an amount of, drying is ground into and adds Rhizoma Paridis fine powder mixing behind the fine powder and get intermediate products C;
(4), add Borneolum Syntheticum among the intermediate products C, add appropriate amount of auxiliary materials by the conventional processing method of each dosage form again and make tablet or capsule, used adjuvant is starch, dextrin, lactose or cane sugar powder.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100639783A CN100402073C (en) | 2005-03-27 | 2005-03-27 | Medicine for treating disease caused by heat toxin |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2005100639783A CN100402073C (en) | 2005-03-27 | 2005-03-27 | Medicine for treating disease caused by heat toxin |
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| CN1686391A CN1686391A (en) | 2005-10-26 |
| CN100402073C true CN100402073C (en) | 2008-07-16 |
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| CN102824515B (en) * | 2012-09-18 | 2015-05-20 | 淄博齐鼎立专利信息咨询有限公司 | Application of Reduqing pills in preparation of medicine for inhibiting A-204 cell proliferation |
| CN104800798A (en) * | 2015-04-26 | 2015-07-29 | 肖付亮 | Medicine for treating mumps and preparation method thereof |
| CN105853965A (en) * | 2016-04-27 | 2016-08-17 | 郑耀玲 | Medicine for treating heat-toxicity internal excess type mastitis and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1197660A (en) * | 1997-04-28 | 1998-11-04 | 王陕清 | Medicine 'Youxiaojing' for eliminating wart |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1197660A (en) * | 1997-04-28 | 1998-11-04 | 王陕清 | Medicine 'Youxiaojing' for eliminating wart |
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