CN101987116A

CN101987116A - Chinese medicinal extract for treating viral herpes and preparation thereof

Info

Publication number: CN101987116A
Application number: CN2009101009021A
Authority: CN
Inventors: 吕月菊
Original assignee: Individual
Current assignee: Individual
Priority date: 2009-08-06
Filing date: 2009-08-06
Publication date: 2011-03-23

Abstract

The invention relates to a Chinese medicinal extract for treating viral herpes and a preparation thereof. Liquorice and honeysuckle serving as main raw materials are subjected to extraction, and the extract can be taken orally or applied externally directly, or processed into granules for internal application, and spray or ointment for external application. The Chinese medicinal extract for treating the viral herpes and the preparation thereof have the effects of clearing heat, drying dampness, purging intense heat and removing toxin, can be applied to skin mucosa lesion, carbuncles and boils and the like, which are caused by toxic heat flourishing and dampness and heat internal obstruction symptoms, such as herpes zoster, hand-foot-and-mouth disease and the like.

Description

A kind of Chinese medicine extract and preparation thereof that virus infected herpes is had therapeutical effect

Technical field

The present invention relates to a kind of virus infected herpes to be had the Chinese medicine extract and the preparation thereof of therapeutical effect, belong to Chinese medicine medicine and manufacturing field.

Background technology

Radix Glycyrrhizae is dicotyledon pulse family Leguminosae Radix Glycyrrhizae Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. G.inflata Bat., or the root and rhizome of Glycyrrhiza glabra L. G.glabra L..Radix Glycyrrhizae has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Flos Lonicerae is the dry flower of caprifoliaceae plant Radix Ophiopogonis Lonicera japonica Thunb. or the flower that band is just opened.The flowers are in blossom gathers drying before putting for early summer.Has heat-clearing and toxic substances removing, wind-heat dissipating.Be used for the carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease heating.Compendium of Material Medica is carried " Flos Lonicerae is good at removing toxic substances, so control carbuncle, toxic swelling, skin ulcer tinea ... ".Since ancient times, Flos Lonicerae is usually used in heat-clearing and toxic substances removing, the heating of treatment epidemic febrile disease, and toxic-heat and blood stasis, diseases such as carbuncle and ulcer also are used for diseases such as anemopyretic cold, bronchitis.Modern pharmacological research shows, that Flos Lonicerae has is antibacterial, antiviral, antiinflammatory, analgesic, regulate effect such as immunity.For pyretic toxicity carbuncle furuncle, there is wuwei xiaodu drink the representative side that Flos Lonicerae is used as medicine, comes from Golden Mirror of Medicine surgery heart method gist side, has heat-clearing and toxic substances removing, the merit of dissipation furuncle.Cure mainly various furunculosiss, the carbuncle furuncle is swollen, and is local red and swollen, burning pain, or fever with chills, red tongue with yellow fur, rapid pulse.

Share for Radix Glycyrrhizae and Flos Lonicerae and to be applied to sore swollen toxin, there is Xian fang Huoming Yin (coming from " married woman's good recipe is annotated in the school ") side of representative, and it is based on heat-clearing and toxic substances removing, and blood-activating and qi-promoting, relieving swelling and disintegrating mass are auxilliary, are called " side first of the panacea of carbuncle sore, surgery ".

Herpes zoster is the easiest popular a kind of viral infection dermatoses in spring, after being infected by varicella zoster virus, hides and sends out in vivo again, causes along innerv skin region banded cluster herpes of arranging to occur, and follows neuralgia.Show as chickenpox (child sees) more clinically or be inapparent infection, it is terminal that after this virus is invaded sensation, again through moving and hiding enduringly in the neuron of spinal cord posterior root ganglion.All can cause the movable again of virus during immunologic hypofunction, excite primary disease.The traditional Chinese medical science thinks that herpes zoster is because liver and gall fire is contained and the spleen damp-stagnancy is of a specified duration, and the diseases caused by exogenous pathogenic factor poison is evil and send out.

Hand-foot-mouth disease is the infectious disease that is caused by enterovirus, and pilosity is born in child below 5 years old, can cause the herpes at positions such as hands, foot, oral cavity, and the minority infant can cause complication such as myocarditis, pulmonary edema, AME.If indivedual serious symptom infant PD are fast, cause death, doctor trained in Western medicine does not still have vaccine and specific treatment medicine at present.According to theory of Chinese medical science, hand-foot-mouth disease belongs to the category of " epidemic febrile disease " in the theory of Chinese medical science, is called as the epidemic disease caused by damp-heat pathogen poison.

The present invention is applicable to multiple herpes, herpetic stomatitis, also has certain curative effect for the hand-foot-mouth disease that is mainly in the juvenile at present, at present general clinical commonly used be the antiviral Western medicine, but the antiviral drugs curative effect has limitation in the market, and certain side effect is arranged, use always and develop immunity to drugs.The present invention selects for use heat-clearing and detoxifying herb to extract directly oral or makes granule, spray or ointment external by preparation, has determined curative effect, is difficult for recurrence, is difficult for producing characteristics such as drug resistance.

Summary of the invention

Research worker of the present invention is to use middle discovery clinical, and Flos Lonicerae and Radix Glycyrrhizae extract combination are to multiple herpes, and herpetic stomatitis has therapeutical effect.

The objective of the invention is to disclose a kind of Chinese medicine extract and preparation thereof that virus infected herpes is had therapeutical effect.The present invention realizes by following scheme:

One method for preparing extractive

30～70 parts of extracting honeysuckles, 30～70 parts of Radix Glycyrrhizae add 8～12 times of water gagings and extract 1～2h, and filtering extracting liquid is condensed into 30～50ml, and once spread upon the affected part with cotton swab per half an hour; Add for the second time 8～12 times of water gagings and extract 1～2h, after concentrating, taking liquid is taken to the patient several times.

Two formulation preparing methods

1. extracting honeysuckle is 30～70 parts, and 30～70 parts of Radix Glycyrrhizae add 8～12 times of water gagings and extract 1～2h, filter; Add for the second time 8～12 times of water gagings and extract 1～2h, merging filtrate is condensed into to 0.5～1.5g/ml, adds certain adjuvant, and spray drying gets electuary, is used to take orally.

2. extracting honeysuckle is 30～70 parts, and 30～70 parts of Radix Glycyrrhizae add 8～12 times of water gagings and extract 1～2h, filter; Add for the second time 8～12 times of water gagings and extract 1～2h, merging filtrate is condensed into 0.5～1.5g/ml, adds certain pharmaceutical adjunct, becomes the spray external, is sprayed on the affected part;

2. extracting honeysuckle is 30～70 parts, and 30～70 parts of Radix Glycyrrhizae add 8～12 times of water gagings and extract 1～2h, filter; Add for the second time 8～12 times of water gagings and extract 1～2h, merging filtrate is condensed into 0.5～1.5g/ml, adds certain pharmaceutical adjunct, makes the ointment external, is applied to the affected part;

The specific embodiment

Embodiments of the present invention are specific as follows:

Embodiment one: extracting honeysuckle 30g, and Radix Glycyrrhizae 30g adds water 500ml and extracts 1h, and filtering extracting liquid is condensed into 30ml, and once spread upon the affected part with cotton swab per half an hour; Add for the second time water 300ml and extract 10min, taking liquid is taken to the patient several times.

Embodiment two: extracting honeysuckle 30g, and Radix Glycyrrhizae 50g adds 10 times of water extraction of water 2 times, and each 1 hour, filtering extracting liquid was condensed into 30ml, adds appropriate amount of starch, is spray dried to granule, was used to take orally.

Embodiment three: extracting honeysuckle 30g, Radix Glycyrrhizae 50g adds 10 times of water extraction of water 2 times, each 1 hour, filtering extracting liquid was condensed into 30ml, add 2 times the amount 95% ethanol precipitate with ethanol after, get supernatant concentration to 30ml, fill is made spray in spray bottle, be sprayed on the affected part.

Embodiment four: extracting honeysuckle 30g, and Radix Glycyrrhizae 50g adds 10 times of water extraction of water 2 times, each 1 hour, filtering extracting liquid is condensed into 30ml, add 2 times of amount 95% ethanol precipitate with ethanol after, get supernatant concentration to doing, get extractum, add adjuvant lanoline 10g, para hydroxybenzene methyl ethyl ester 0.2g, make ointment.

Claims

1. one kind has the Chinese medicine extract and the preparation thereof of therapeutical effect to virus infected herpes, it is characterized in that:

(1) this Chinese drug-treated group becomes: Flos Lonicerae, and Radix Glycyrrhizae is perhaps based on the prescription adjustment on above-mentioned two kinds of Chinese medicine bases;

(2) the Flos Lonicerae consumption is 30～70 parts, and the Radix Glycyrrhizae consumption is 30～70 parts;

(3) extracting method: take by weighing a certain amount of Flos Lonicerae and Radix Glycyrrhizae, add 8～12 times of water extraction 1～3 time, merging filtrate is concentrated into finite concentration, is coated with outside being used for or takes orally;

(4) preparation type: take by weighing a certain amount of Flos Lonicerae and Radix Glycyrrhizae, add 8～12 times of water extraction 1～3 time, merging filtrate is concentrated into finite concentration, adds appropriate amount of auxiliary materials, can be made into granule and takes spray, ointment external orally;

2. according to claim 1 a kind ofly have the Chinese medicine extract and the preparation thereof of therapeutical effect to virus infected herpes, it is characterized in that:

This Chinese drug-treated group of described step (1) becomes: Flos Lonicerae, Radix Glycyrrhizae, perhaps based on the prescription adjustment on above-mentioned two kinds of Chinese medicine bases; Wherein Radix Glycyrrhizae is a Radix Glycyrrhizae;

3. according to claim 1 a kind ofly have the Chinese medicine extract and the preparation thereof of therapeutical effect to virus infected herpes, it is characterized in that:

Described step (2) in this survival dose be: Flos Lonicerae is 30～70 parts, and the Radix Glycyrrhizae consumption is 30～70 parts, perhaps based on the prescription adjustment on above-mentioned two kinds of Chinese medicine bases;

4. according to claim 1 a kind ofly have the Chinese medicine extract and the preparation thereof of therapeutical effect to virus infected herpes, it is characterized in that:

The detailed process of described step (3) is: take by weighing 30～70 parts of a certain amount of Flos Loniceraes, 30～70 parts in Radix Glycyrrhizae, take by weighing a certain amount of Flos Lonicerae and Radix Glycyrrhizae, add 8～12 times of water extraction 1～3 time, merging filtrate is concentrated into finite concentration, is coated with outside being used for or takes orally;

5. according to claim 1 a kind ofly have the Chinese medicine extract and the preparation thereof of therapeutical effect to virus infected herpes, it is characterized in that:

The detailed process of described step (4) is: press any proportioning of extract and adjuvant, adopt conventional method to prepare granule, spray, ointment, the pharmaceutical adjunct of adjuvant for being complementary with it.