CN1255170C - Cough-relieving bagged tea and its prepn - Google Patents
Cough-relieving bagged tea and its prepn Download PDFInfo
- Publication number
- CN1255170C CN1255170C CN 02133709 CN02133709A CN1255170C CN 1255170 C CN1255170 C CN 1255170C CN 02133709 CN02133709 CN 02133709 CN 02133709 A CN02133709 A CN 02133709A CN 1255170 C CN1255170 C CN 1255170C
- Authority
- CN
- China
- Prior art keywords
- cough
- relieving
- radix
- bagged tea
- thick paste
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 206010011224 Cough Diseases 0.000 title claims abstract description 45
- 241001122767 Theaceae Species 0.000 title claims description 32
- 239000000843 powder Substances 0.000 claims abstract description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000000341 volatile oil Substances 0.000 claims abstract description 12
- 238000002156 mixing Methods 0.000 claims abstract description 10
- 238000001035 drying Methods 0.000 claims abstract description 5
- 238000007873 sieving Methods 0.000 claims abstract description 3
- 239000003814 drug Substances 0.000 claims description 30
- 229940079593 drug Drugs 0.000 claims description 20
- 239000003795 chemical substances by application Substances 0.000 claims description 17
- 239000000796 flavoring agent Substances 0.000 claims description 8
- 235000019634 flavors Nutrition 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 6
- 238000004821 distillation Methods 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 4
- 239000002994 raw material Substances 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- 238000005469 granulation Methods 0.000 claims description 2
- 230000003179 granulation Effects 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 abstract description 16
- 239000004615 ingredient Substances 0.000 abstract description 11
- 239000000203 mixture Substances 0.000 abstract description 4
- 230000008901 benefit Effects 0.000 abstract description 2
- 244000269722 Thea sinensis Species 0.000 abstract 5
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 4
- 241000951473 Schizonepeta Species 0.000 abstract 3
- 241000675108 Citrus tangerina Species 0.000 abstract 2
- 241000490229 Eucephalus Species 0.000 abstract 2
- 235000006753 Platycodon grandiflorum Nutrition 0.000 abstract 2
- 240000003582 Platycodon grandiflorus Species 0.000 abstract 2
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017443 Hedysarum boreale Nutrition 0.000 abstract 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 abstract 1
- 241001671204 Stemona Species 0.000 abstract 1
- 241001247477 Vincetoxicum hirundinaria Species 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 abstract 1
- 238000010298 pulverizing process Methods 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
- 238000001256 steam distillation Methods 0.000 abstract 1
- 235000013616 tea Nutrition 0.000 description 30
- 230000000954 anitussive effect Effects 0.000 description 12
- 229940124584 antitussives Drugs 0.000 description 12
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 12
- 206010062717 Increased upper airway secretion Diseases 0.000 description 7
- 208000026435 phlegm Diseases 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 5
- 241000721047 Danaus plexippus Species 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 4
- 239000002552 dosage form Substances 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 238000003305 oral gavage Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000029142 excretion Effects 0.000 description 2
- 238000003304 gavage Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 230000003285 pharmacodynamic effect Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010063659 Aversion Diseases 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 241000305071 Enterobacterales Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 208000036119 Frailty Diseases 0.000 description 1
- 206010020710 Hyperphagia Diseases 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 241000191938 Micrococcus luteus Species 0.000 description 1
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 231100000682 maximum tolerated dose Toxicity 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 235000015091 medicinal tea Nutrition 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 208000022530 polyphagia Diseases 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- -1 sheet Substances 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to cough-relieving bagged tea and a preparation method thereof. The bagged tea is prepared from 7 kinds of traditional Chinese medicines of prepared aster, prepared stemona root, white swallowwort, balloonflower root, fineleaf schizonepeta herb, tangerine peel, licorice root, etc. The preparation method comprises the following steps: respectively pulverizing the aster, the balloonflower roots and the tangerine peel into medium powder, extracting volatile oil from the fineleaf schizonepeta herb with water steam distillation, decocting other three kinds of traditional Chinese medicines with water many times, filtering and combining filter liquor, concentrating the filter liquor into thick paste with a certain relative density, mixing the thick paste with the medium powder, sieving and palletizing the mixture of the thick paste and the medium powder, drying the product at lower temperature, spraying the volatile oil of the fineleaf schizonepeta herb, uniformly mixing the new mixture, separately bagging the new mixture and obtaining the cough-relieving bagged tea. The preparation method has the advantages that the original powder is changed into bagged tea for ensuring that the effective ingredients of the traditional Chinese medicines can be dissolved quickly and fully, more volatile ingredients of the traditional Chinese medicines are reserved, and the cough-relieving bagged tea is convenient to take and is portable.
Description
Technical field
The invention belongs to the Chinese patent medicine preparation technical field of treatment cough, be specifically related to a kind of cough-relieving bagged tea agent.
Technical background
Zhisou San is the name side of the treatment cough of the well-known doctor Cheng Zhongling of Qing Dynasty initiative, has the merit of dispelling wind to relieve the exterior syndrome, relieving cough and resolving phlegm, is used for wind and cold and violates cough, itching throat, the not well patient that coughs up phlegm that lung causes, has better therapeutic effect.Former side is to grind after medicine is followed an example to do to be smalls for being taken after mixing with liquid powder, is taken after mixing with liquid with boiled water or Rhizoma Zingiberis Recens soup.Herba Schizonepetae, the contained fragrance ingredient of Pericarpium Citri Reticulatae are easy to volatilization in the side, should not fry in shallow oil for a long time.Because of lacking its heat time heating time, so can keep its volatile ingredient morely.But powder is used for the modern, and real is inconvenience.So the descendant changes it into dosage forms such as sheet, ball, oral liquid, granule, though have his own strong points, all has certain problem: the antitussive ball has the shortcoming that disintegrate is slow, onset is slow.Antitussive granule sugar content height, crowd's use of middle-aged and elderly people and unsuitable polyphagia saccharide is restricted.The antitussive oral liquid has used antiseptic, and carries inconvenience.The more former side's powder of antitussive sheet, though have easy to carryly, consumption is accurate, advantage such as be convenient to take, but because in preparation process, except that Radix Platycodonis was beaten powder, all the other 6 flavors were all used water extraction, the effective ingredient heated time is long in the monarch drug Radix Asteris, influential to curative effect, simultaneously, oversize to the heat time heating time of Herba Schizonepetae, Pericarpium Citri Reticulatae, its volatile ingredient is lost in a large number, also influenced our therapeutic effect to a certain extent.In addition, behind pill, the tablet clothes, need to absorb then, distribute through gastrointestinal tract disintegrate, dissolving, can onset, be applicable to chronic, kidney disease, as LIUWEI DIHUANG WAN and so on, and be not suitable for emergency case.Positive so-called " the ball person, slow also, releive and control also ".
Summary of the invention
The present invention is directed to Zhisou San and change the existing deficiency of multiple medicine that agent forms, a kind of cough-relieving bagged tea agent is provided, through modern Study on Preparation, former side is made bag tea agent, both guaranteed quick, the fully stripping of middle pharmaceutically active ingredient, keep volatile ingredient with effect again morely, and take, easy to carry.
The present invention adopts system Radix Asteris, Radix Stemonae, Rhizoma Cynanchi Stauntonii, Radix Platycodonis, Herba Schizonepetae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae seven flavor Chinese medicines to form, and the weight portion of raw material is: system Radix Asteris 1000, Rhizoma Cynanchi Stauntonii 1000, Herba Schizonepetae 1000, Radix Glycyrrhizae 500, Radix Stemonae 500, Radix Platycodonis 1000, Pericarpium Citri Reticulatae 500.
Show that according to the study dosage form has influence to the stripping and the absorption of effective ingredient in the Chinese medicine preparation.Teabag is to study more a kind of novel form in recent years, has the expert to prove that from many aspects the water-soluble extractives of bag tea agent is higher than decoct.Recipe structure, formulation characteristic, pharmacodynamic properties, the function of inventor by research Zhisou San cure mainly and interrelated data such as the scope of application after, think if Zhisou San is developed as patent medicine, be more suitable for making bag tea agent, because bag tea agent and powder are immediate.And bag tea agent belong to that China's " pharmacopeia " (version in 2000) record 21 in one of preparation, mean that the medical material that contains Folium Camelliae sinensis or do not contain Folium Camelliae sinensis or medicinal substances extract are with the preparation of taking with boiled water.
Key of the present invention is that former side has been made bag tea agent, makes it more to approach former side's powder, and theory of Chinese medical science is thought: " person that looses looses also ".Previous " loosing " word refers to dosage form; " loosing " word in back refers to disperse.The treatment exogenous cough is when with the method for dispersing.Simultaneously, in preparation, fully take into account the performance to greatest extent of the drug effect of every Herba indigoferae Pseudotinctoriae, adopted best process flow and advanced pharmaceutical equipment.
This bag tea agent preparation method is as follows: get powder in Radix Asteris, Radix Platycodonis, the Pericarpium Citri Reticulatae pulverize separately one-tenth; Herba Schizonepetae is extracted volatile oil with vapor distillation; All the other 3 flavor medicines decoct with water for several times each 1 hour; Filter, merging filtrate is concentrated into the thick paste of certain relative density, with above-mentioned in the powder mixing, the granulation of sieving, cold drying sprays into Herba Schizonepetae volatile oil again, mixing is distributed into bag, promptly.
Former antitussive sheet preparation technology only Radix Platycodonis gets powder, in cough-relieving bagged tea agent preparation technology of the present invention, considers that 6 flavor liquid medicine fried cream are too much, Radix Platycodonis absorption not exclusively, in addition, even extractum all adds, the moisture absorption very easily after the drying.In order to reduce loss of active ingredients in the monarch drug Radix Asteris as far as possible, need not make very these characteristics of small size in conjunction with medicinal tea, therefore increased the powder amount of getting of medicine.Radix Asteris is a monarch drug among the we, and Pericarpium Citri Reticulatae contains volatile oil, easily loses during decocting, and therefore except that Radix Platycodonis was got powder, Radix Asteris and Pericarpium Citri Reticulatae were also got powder.Though Herba Schizonepetae also contains volatile oil, if get powder, then full side has 4 flavor medicines to get powder, and it is too big to get the powder amount, and each dosage can surpass 5.5g, and the dosage of Herba Schizonepetae not being got powder at present only is 2.9g.
According to another bibliographical information, the effective ingredient of Herba Schizonepetae is a volatile oil, have eliminating the phlegm, relieving asthma, pharmacological effect such as calmness, analgesia, and water decoction do not have relieving asthma, phlegm-dispelling functions, therefore consider from drug effect mediating recipe structural synthesis factor that Herba Schizonepetae adopts the technology of vapor distillation effective component extracting volatile oil more suitable.Tcm prescription is always paid attention to compatibility, is cough because we cure mainly emphasis, so Herba Schizonepetae is adjuvant drug but not monarch drug, the dispelling wind to relieve the exterior syndrome of Herba Schizonepetae acts on that non-its medicine can substitute among the we.Pine for losing adding for the volatile ingredient of avoiding Herba Schizonepetae, it is cough-relieving bagged tea that the antitussive sheet is changed dosage form, can keep the effect of its dispelling wind to relieve the exterior syndrome to greatest extent.
Crude drug source, kind in this bag tea agent all meets " pharmacopeia " (version in 2000) standard, and wherein making Radix Asteris is the Radix Asteris sheet, fries to tack-free according to appendix honey-fried method of " pharmacopeia " (version in 2000).Radix Stemonae also is same requirement.
Below be main pharmacodynamics experimental result to antitussive bagged steeping drug of the present invention:
1. pharmacological evaluation:
(1) its mouse oral gavages cough-relieving bagged tea 1.256,2.512 and 5.024g (crude drug)/kg, obviously prolongs by ammonia to draw cough latent period of coughing and the minimizing of coughing number of times in 3 minutes;
(2) the Cavia porcellus per os gavages cough-relieving bagged tea 1.256,2.512 and 5.024g (crude drug)/kg, obviously prolongs by 17.5% citric acid to draw cough latent period of coughing and the minimizing of coughing number of times in 5 minutes;
(3) its mouse oral gavages cough-relieving bagged tea 1.256,2.512 and 5.024g (crude drug)/kg, and the phenol red amount of mice trachea excretion is obviously increased.Illustrate that cough-relieving bagged tea can promote respiratory tract excretion amount to increase, and reaches phlegm-dispelling functions;
(4) its mouse oral gavages cough-relieving bagged tea 1.256,2.512 and 5.024g (crude drug/kg increases normal mouse sweat secretion number, illustrates that cough-relieving bagged tea can promote sweat secretion;
(5) cough-relieving bagged tea is to isolating clinical 81 common strain pathogenic bacterium (Gram-positive and negative aerobe), except that escherichia coli, class enterobacteria, micrococcus luteus and Ke Shi pneumobacillus debility, other bacterium all has certain bacterium effect of doing, MIC is 0.15-19.3g (crude drug)/L, illustrates that cough-relieving bagged tea has certain antibacterial action.
Above-mentioned every test is all carried out with antitussive sheet contrast, studies show that: cough-relieving bagged tea in antitussive, eliminate the phlegm and aspect such as perspire, all slightly be better than the effect of antitussive sheet.
2 toxicological studies
Acute toxicity test: with cough-relieving bagged tea 38.6g (crude drug)/kg, per os gavages Kunming mouse 2 times, and accumulated dose is 77.2g (crude drug)/kg.Observed 7 days continuously, do not have any side reaction and death.The mice maximum tolerated dose is greater than 77.2g (crude drug)/kg.Be 59.3 times of human clinical dosage.The result shows that cough-relieving bagged tea toxicity is low, is safe to human oral..
3 clinical researches
Clinical efficacy and safety thereof for objective evaluation cough-relieving bagged tea treatment cold cough, through being ratified in the 1-6 month in 2000, be responsible for by Medical University Of Chongqing clinical pharmacology base, carried out II phase clinical research in its attached hospital, two hospitals and southwest hospital of Third Military Medical University, carry out clinical trial 173 examples altogether, wherein 102 examples are organized in treatment, matched group 71 examples.The result shows: cough-relieving bagged tea to cough, cough up phlegm, the curative effect of symptom such as aversion to wind and cold, itching throat obviously is better than antitussive sheet (P＜0.01).Treatment group and control patients treatment, bleeding from anus, urine, stool routine examination, electrocardiogram, hepatic and renal function, all case of no abnormal variation.
The agent of this cough-relieving bagged tea is under Chinese medical theory instructs, by modern Study on Preparation, and the novel pure Chinese medicinal preparation that adopts best process flow to be processed into.And big characteristics of bag tea agent are that absorption, onset are very fast, and medicinal liquid is in case inlet gets final product onset through the direct absorption of the abundant blood capillary of hypoglossis mucous membrane.Tcm theory is thought, the disease that exogenous cough, pathogenic factor in the exterior are not most, and sick position is defended at flesh table, lung, belongs to the part of the body cavity above the diaphragm housing the heart and lungs.Famous Lee physician in Jin Dynasty east is permanent to be said: " sick last person, bored and lack; Sick infra person, not bored and many ".The instructions about how to take medicine of cough-relieving bagged tea meet saying of east perseverance.The reason that also meets " controlling the part of the body cavity above the diaphragm housing the heart and lungs such as plumage, non-light silent the act ".Show through zoopery and clinical effectiveness: the antitussive bagged steeping drug both guaranteed middle pharmaceutically active ingredient fast, fully stripping, can keep its volatile ingredient again morely, it is few to have consumption simultaneously, volume is little, and comfortable taste is easy to carry, be beneficial to preservation, technology is simple, the characteristics that are easy to produce.On present domestic and international market, also there is not under a kind of situation of bag tea agent for the treatment of cough the can yet be regarded as a kind of new drug of treatment cough of safe, effective, quality controllable, taking convenience of cough-relieving bagged tea agent.
Embodiment:
Prescription is formed (weight g): system Radix Asteris 1000, Rhizoma Cynanchi Stauntonii 1000, Herba Schizonepetae 1000, Radix Glycyrrhizae 500, Radix Stemonae 500, Radix Platycodonis 1000, Pericarpium Citri Reticulatae 500.
Medicine-feeding is made 1000 bags as method, and every bag heavy 2.9g, each 1 bag, takes with boiled water at every day 2 times.
Preparation technology: get Radix Asteris, Radix Platycodonis and the Pericarpium Citri Reticulatae of recipe quantity, powder during pulverize separately becomes.Herba Schizonepetae is extracted volatile oil with vapor distillation, and all the other 3 flavor medicines are put and decocted with water three times in the multi-function extractor, 10 times of water gagings for the first time, and 8 times of water gagings of second and third time, decocting time respectively are 1 hour.Collecting decoction filters, and gets brown solution, and filtrate is condensed into the thick paste that relative density is 1.15-1.18 (about 65 ℃), and volume is 2L.With powder and thick paste mixings such as Radix Asteriss, to cross 10 mesh sieves and granulate, cold drying sprays into Herba Schizonepetae volatile oil, and mixing is distributed into 1000 bags, promptly.
Claims (2)
1, a kind of teabag that is used for the treatment of cough, it is characterized in that it is the bag tea agent of being made by the following method by the following weight proportion raw material: raw material system Radix Asteris 1000, Radix Stemonae 500, Rhizoma Cynanchi Stauntonii 1000, Radix Platycodonis 1000, Herba Schizonepetae 1000, Pericarpium Citri Reticulatae 500, Radix Glycyrrhizae 500, get Radix Asteris, Radix Platycodonis, powder during the Pericarpium Citri Reticulatae pulverize separately becomes, Herba Schizonepetae is extracted volatile oil with vapor distillation, residue and its excess-three flavor medicine decoct with water, filter, merging filtrate is condensed into the thick paste that relative density is 1.15-1.18 with filtrate, under 65 ℃, then with thick paste and above-mentioned middle powder mixing, the granulation of sieving, cold drying, spray into Herba Schizonepetae volatile oil again, mixing is distributed into bag, promptly.
2, teabag according to claim 1 is characterized in that: Radix Stemonae, Radix Glycyrrhizae, Rhizoma Cynanchi Stauntonii three flavor medicines decoct with water three times, 10 times of water gagings for the first time, and 8 times of water gagings of second and third time, decocting time respectively are 1 hour.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02133709 CN1255170C (en) | 2002-09-04 | 2002-09-04 | Cough-relieving bagged tea and its prepn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02133709 CN1255170C (en) | 2002-09-04 | 2002-09-04 | Cough-relieving bagged tea and its prepn |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1403130A CN1403130A (en) | 2003-03-19 |
| CN1255170C true CN1255170C (en) | 2006-05-10 |
Family
ID=4747349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02133709 Expired - Fee Related CN1255170C (en) | 2002-09-04 | 2002-09-04 | Cough-relieving bagged tea and its prepn |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1255170C (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101077103B (en) * | 2007-06-28 | 2011-03-09 | 王秀文 | Inflammation-diminishing and cough-controlling tea |
| CN101073348B (en) * | 2007-06-28 | 2010-12-01 | 范传玲 | Health-care tea soup with lung-moistening and cough-stopping functions |
| CN102038052A (en) * | 2009-10-22 | 2011-05-04 | 李红岩 | Preparation and production method of coarse cereal tea |
| CN104147189A (en) * | 2014-07-01 | 2014-11-19 | 扬中牧乐药业有限公司 | Oral liquid for treating infectious bronchitis and laryngotracheitis of poultry |
| CN104256001A (en) * | 2014-09-13 | 2015-01-07 | 刘秀珠 | Herbal tea for treating wind-heat cough |
| CN104186861A (en) * | 2014-09-13 | 2014-12-10 | 刘秀珠 | Chinese herbal tea for treating wind-cold caused cough |
| CN107137369A (en) * | 2017-06-07 | 2017-09-08 | 南京晶云化工有限公司 | One kind stops ball and its preparation method and application of coughing |
-
2002
- 2002-09-04 CN CN 02133709 patent/CN1255170C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1403130A (en) | 2003-03-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101972338B (en) | Chinese medicinal preparation for treating infantile upper respiratory tract infection and preparation method thereof | |
| CN103520572A (en) | Traditional Chinese composition used for treating atopic dermatitis as well as preparation method of composition | |
| CN102284022A (en) | Cough medicament and preparation method thereof | |
| CN1742939B (en) | Medicine for treating pulmonary fibrosis and preparing method | |
| CN1255170C (en) | Cough-relieving bagged tea and its prepn | |
| CN101049424B (en) | Medication for treating infection in respiratory system | |
| CN104147572A (en) | Cold and fever wind-dispelling and heat-dispersing preparation and preparation method | |
| CN103990103A (en) | Medicine for local anaesthesia and preparation method of medicine | |
| CN102847061B (en) | Traditional Chinese medicine preparation for treating pediatric viral myocarditis and preparation method thereof | |
| CN104857366A (en) | Preoperative intervention medicine composition for neurosurgery and application thereof | |
| CN107625828A (en) | A kind of health protection tea for auxiliary treatment chronic pharyngitis, preparation method and application | |
| CN103007145B (en) | Traditional Chinese medicine composition for treating children rotavirus enteritis and preparation method of composition | |
| CN105343660A (en) | A traditional Chinese medicine preparation for treating peripheral vertigo and its preparation method | |
| CN1218733C (en) | Medicine for treating common cold and preparation method | |
| CN100386106C (en) | Medicine for treating acne and its preparation | |
| CN108186821B (en) | Traditional Chinese medicine composition for treating nervous headache and preparation method and application thereof | |
| CN100402073C (en) | Medicine for treating disease caused by heat toxin | |
| CN100486621C (en) | Chinese medicinal composition for treating hemilateral headache and its preparation method | |
| CN1970050B (en) | Pharmaceutical composition for treating arrhythmia and preparation process thereof | |
| CN110101791A (en) | A kind of pharyngitis mouth-sucking tablet and preparation method thereof | |
| CN108498700A (en) | A kind of Chinese medicine composition and preparation method thereof for treating cough | |
| CN107095977A (en) | A kind of medicament and its pharmaceutical formulation and preparation method with the malicious effect of fire row of dispelling | |
| CN102133274A (en) | Chinese medicinal composition | |
| CN106728729A (en) | A kind of clinical anesthesia Chinese medicine preparation for gastrocopy | |
| CN106039075A (en) | Traditional Chinese medicine composition and method for treating lung and stomach heat accumulated type chronic pharyngitis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: CHONGQING LIWEI PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: XIE YASU Effective date: 20130701 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 400039 DADUKOU, CHONGQING TO: 400060 NANAN, CHONGQING |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20130701 Address after: 400060, Chongqing city open area (both on the south bank area) four District Jinshan Branch 4, 3 -1 Patentee after: Chongqing Liwei Medicine Co., Ltd. Address before: 400039 Chongqing high tech Zone Shiqiaopu Chongqing Plaza B block No. 2-10-7 Patentee before: Xie Yasu |
|
| ASS | Succession or assignment of patent right |
Owner name: WANG HAIYAN Free format text: FORMER OWNER: CHONGQING LIWEI PHARMACEUTICAL CO., LTD. Effective date: 20131015 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 400060 NANAN, CHONGQING TO: 402679 TONGNAN, CHONGQING |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20131015 Address after: 402679, No. 4, No. 48, village 1, Buddha town, Tian Jia village, Chongqing County, Tongnan Patentee after: Wang Haiyan Address before: 400060, Chongqing city open area (both on the south bank area) four District Jinshan Branch 4, 3 -1 Patentee before: Chongqing Liwei Medicine Co., Ltd. |
|
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20060510 Termination date: 20150904 |
|
| EXPY | Termination of patent right or utility model |