CN107095977A - A kind of medicament and its pharmaceutical formulation and preparation method with the malicious effect of fire row of dispelling - Google Patents

A kind of medicament and its pharmaceutical formulation and preparation method with the malicious effect of fire row of dispelling Download PDF

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CN107095977A
CN107095977A CN201710496271.4A CN201710496271A CN107095977A CN 107095977 A CN107095977 A CN 107095977A CN 201710496271 A CN201710496271 A CN 201710496271A CN 107095977 A CN107095977 A CN 107095977A
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parts
medicament
dispelling
pharmaceutical formulation
fire row
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吴泉兴
方奋宗
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/87Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/68Plantaginaceae (Plantain Family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/78Saururaceae (Lizard's-tail family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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Abstract

The invention provides a kind of medicament with the malicious effect of fire row of dispelling and its pharmaceutical formulation and preparation method, belong to drug field.The medicament is made by pharmaceutical formulation, and the pharmaceutical formulation includes:Treebine stem, Linear Leaf Speedwell, cordate houttuynia, pen grass, Chinese lantern, Mao Xu Cao, Asiatic plantain and tassel flower.The pharmaceutical formulation is using treebine stem, Linear Leaf Speedwell and cordate houttuynia as monarch drug in a prescription, with malicious, the clearing heat and detoxicating effect of fire row of dispelling well, can treat the various diseases because caused by fiery poison, rapid-action, Small side effects.The preparation method of the medicament includes:Herbal medicine in pharmaceutical formulation is mixed, extracted using solvent extraction method.This method is simple and easy to apply, can largely avoid effective component from being destroyed, resulting curative effect of medicine is good.

Description

A kind of medicament and its pharmaceutical formulation and preparation method with the malicious effect of fire row of dispelling
Technical field
The present invention relates to drug field, match somebody with somebody in particular to a kind of medicament and its medicine with the malicious effect of fire row of dispelling Side and preparation method.
Background technology
The traditional Chinese medical science thinks that fire is that easy injury-gas consumption easily gives birth to pneumatic blood, easily sends out large carbuncle in yang pathogens, its property inflammation." excessive internal heat " is people Each organ of body is uncoordinated to be caused, medically referred to as stress disease.Human body can not keep the balance of metabolism and steady In the case of fixed, easily there is physiological dysfunction and cause metabolic toxicities to discharge in time, long term accumulation triggers into fiery poison " excessive internal heat " symptom, is mainly shown as:Anemopyretic cold, fever, aphthae, abscess of throat, heatstroke, insomnia etc..At present, in insomnia Curative effect for a variety of diseases caused by fiery poison is poor.
The content of the invention
The first object of the present invention is offer a kind of pharmaceutical formulation and medicament with the malicious effect of fire row of dispelling, and the medicine is matched somebody with somebody Side is using treebine stem, Linear Leaf Speedwell and cordate houttuynia as monarch drug in a prescription, with malicious, the clearing heat and detoxicating effect of fire row of dispelling well, can treat each Plant because of the disease caused by fiery poison, rapid-action, Small side effects.
The second object of the present invention is to provide a kind of preparation method of the medicament with the malicious effect of fire row of dispelling, this method letter It is single easy, it can largely avoid effective component from being destroyed.
In order to realize the above-mentioned purpose of the present invention, spy uses following technical scheme:
A kind of pharmaceutical formulation with the malicious effect of fire row of dispelling, the pharmaceutical formulation count by weight including:
35~45 parts of treebine stem, 30~38 parts of Linear Leaf Speedwell, 15~20 parts of 30~37 part, grass of cordate houttuynia, Chinese lantern 25~ 15~20 parts of 30 parts, 25~30 parts of Mao Xu Cao, 25~30 parts of Asiatic plantain and tassel flower.
A kind of medicament with the malicious effect of fire row of dispelling, the medicament is made by said medicine formula.
A kind of preparation method of the medicament with the malicious effect of fire row of dispelling, it includes:Herbal medicine in pharmaceutical formulation is mixed, adopted Extracted with solvent extraction method.
Compared with prior art, beneficial effects of the present invention are:
This pharmaceutical formulation and medicament with the malicious effect of fire row of dispelling that present disclosure is provided, with treebine stem, Linear Leaf Speedwell It is monarch drug in a prescription with cordate houttuynia, plays the effect for fire removing toxic substances of dispelling;It is aided with pen grass, Chinese lantern, Mao Xu Cao, Asiatic plantain and tassel flower, phase Mutual restriction, strengthening vital QI to eliminate pathogenic factors, dispel fiery poison, adjust the function of patient's vital organs of the human body, correction because of the pathological state caused by preponderance of YANG QI, The various diseases because caused by fiery poison, rapid-action, Small side effects can be treated.
The preparation method for this medicament that present disclosure is provided, it is simple and easy to apply, it is workable, can be largely Avoid effective component from being destroyed, the content of active principle in medicament is remained, so as to ensure drug effect.
Embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.It is unreceipted specific in embodiment Condition person, the condition advised according to normal condition or manufacturer is carried out.Agents useful for same or the unreceipted production firm person of instrument, be The conventional products that can be obtained by commercially available purchase.
Present embodiment provides a kind of pharmaceutical formulation with the malicious effect of fire row of dispelling, and the pharmaceutical formulation counts bag by weight Include:
35~45 parts of treebine stem, 30~38 parts of Linear Leaf Speedwell, 15~20 parts of 30~37 part, grass of cordate houttuynia, Chinese lantern 25~ 15~20 parts of 30 parts, 25~30 parts of Mao Xu Cao, 25~30 parts of Asiatic plantain and tassel flower.
Further, count by weight, 37~43 parts of treebine stem, 32~37 parts of Linear Leaf Speedwell, cordate houttuynia 32~36 part, 16~19 parts of 16~19 parts of grass, 26~28 parts of Chinese lantern, 26~28 parts of Mao Xu Cao, 26~29 parts of Asiatic plantain and tassel flower.
Further, count by weight, 39~41 parts of treebine stem, 33~35 parts of Linear Leaf Speedwell, cordate houttuynia 32~35 part, 16~18 parts of 16~18 parts of grass, 26~28 parts of Chinese lantern, 26~28 parts of Mao Xu Cao, 26~28 parts of Asiatic plantain and tassel flower.
More specifically, count by weight, 40 parts of treebine stem, 34 parts of Linear Leaf Speedwell, 17 parts of 34 part, grass of cordate houttuynia, lamp 17 parts of 27 parts of cage grass, 27 parts of Mao Xu Cao, 27 parts of Asiatic plantain and tassel flower.
This pharmaceutical formulation with the malicious effect of fire row of dispelling that the present embodiment is provided, with treebine stem, Linear Leaf Speedwell and cordate houttuynia For monarch drug in a prescription, the effect for fire removing toxic substances of dispelling is played.Wherein, treebine stem, with dispelling wind and eliminating dampness, function promoting blood circulation and removing obstruction in channels;Linear Leaf Speedwell, has Nourishiing yin to clear away the lung-heat, the function of dissolving stasis and hemostasis.When this two tastes medicinal material is used alone, it is of limited application, the two compatibility is used, can Make it have effect of prominent fire removing toxic substances of dispelling.Meanwhile, cordate houttuynia, clearing heat and detoxicating, inducing diuresis to remove edema function, therewith phase interworking 5, it can further strengthen effect of the fire removing toxic substances of dispelling of treebine stem and Linear Leaf Speedwell.
This pharmaceutical formulation with the malicious effect of fire row of dispelling that the present embodiment is provided, is aided with pen grass, Chinese lantern, cat's whisker Grass, Asiatic plantain and tassel flower, mutual restriction, strengthening vital QI to eliminate pathogenic factors, dispel fiery poison.Wherein, pen grass, has effects that heat-clearing, Li Shui, Used herein with cordate houttuynia compatibility, Li Shui effect enhancings, so as to effectively prevent the sharp water deficiency that the pharmaceutical formulation is likely to occur Disadvantage.Asiatic plantain has effects that diuresis, heat-clearing, improving eyesight, eliminating the phlegm, and its disease to urinary system has more significant treatment Effect.Chinese lantern has effects that to clear liver and improve vision, powder detoxifcation, its to breathing problem by very strong specific aim, such as to throat Swell and ache, the disease such as pharyngitis.Mao Xu Cao, has effects that clearing heat and expelling damp, row stone Li Shui, the addition of this taste medicinal material so that the medicine Formula has good curative effect to prevention and treatment calculus.Tassel flower, is called redback chrismashush root and leaf, with heat-clearing, Li Shui, cool blood, removing toxic substances Effect, has preferable curative effect for system infections, sphagitis and carbuncle.
As can be seen here, the pharmaceutical formulation can adjust the work(of patient's vital organs of the human body by the mutual compatibility of this eight kinds of herbal medicine Can, correct because of the pathological state caused by preponderance of YANG QI, so as to treat the various diseases because caused by fiery poison, rapid-action, Small side effects.
Present embodiment also provides a kind of medicament with the malicious effect of fire row of dispelling, and the medicament is made by said medicine formula 's.The medicament has malicious, clearing heat and detoxicating effect of fire row of dispelling well, can treat the various diseases because caused by fiery poison, such as Anemopyretic cold, inflammation, fever, aphthae, abscess of throat, pharyngitis, heatstroke, insomnia, air conditioner disease etc., rapid-action, Small side effects. In addition, inventor has found that the medicament also has effects that drop stomach fire, defaecation, and it drinks in winter in medication practice for many years Cold air can be dispelled, and obvious therapeutic action is respectively provided with to tumour and various inflammation.
Further, the formulation of the medicament includes but is not limited to:Decoction, pill, powder, tablet, capsule, pulvis and Any one in granula.These formulations are the formulation commonly used in Chinese patent drug, and it can be adopted based on above-mentioned pharmaceutical formulation Prepared with conventional method of the prior art.It is preferred that, the medicament is granule, is convenient for carrying and takes.
Present embodiment also provides a kind of preparation method of the medicament with the malicious effect of fire row of dispelling, and it includes:By the medicine Herbal medicine mixing in composition formula, is extracted using solvent extraction method.
Further, the solvent extraction method includes but is not limited to:Decocting method, percolation, heating and refluxing extraction method and immersion Any one in method.When being extracted using solvent extraction method to above-mentioned medicinal material, extraction solution used include water, ethanol- At least one of water mixed solution, the mixed solution of methanol-water and ethyl acetate.
Selectable, solvent extraction method is that the Extraction solvent in heating and refluxing extraction method, the heating and refluxing extraction method is Volume fraction is 60~80% ethanol solution.Active ingredient in these medicinal materials is soluble in the second that volume fraction is 60~80% Alcoholic solution, is extracted using heating and refluxing extraction method, and method is simple, be easy to control.It is selectable, heating and refluxing extraction method Heating-up temperature is 70~80 DEG C or is 74~76 DEG C, or is 75 DEG C.It is selectable, during the extraction of heating and refluxing extraction method Between be 1.5~2.5h, be either 1.8~2.3h or be 2h.
Optionally, before being extracted using solvent extraction method, in addition to each medicinal material drying in pharmaceutical formulation is crushed to 4 ~20 mesh, are either 6~14 mesh or are 8~12 mesh, or are 10 mesh.Before the medicinal material in pharmaceutical formulation is extracted, First by pulverizing medicinal materials to fine-powdered, be conducive to improving the dissolution rate of effective substance, extraction efficiency improved, to be further ensured that the medicine The drug effect of agent.
The preparation method of this medicament, it is simple and easy to apply, it is workable, it can largely avoid effective component to be broken It is bad, the content of active principle in medicament is remained, so as to ensure drug effect.
The feature and performance to the present invention are described in further detail with reference to embodiments:
Embodiment 1
The present embodiment provides a kind of medicament with the malicious effect of fire row of dispelling, and the medicament is made by following drugs:
Treebine stem 45g, Linear Leaf Speedwell 38g, cordate houttuynia 30g, pen grass 20g, Chinese lantern 30g, Mao Xu Cao 25g, Asiatic plantain 25g, And tassel flower 20g.
The preparation method of the medicament includes:
Herbal medicine mixing during said medicine is formulated, is extracted using decocting method, that is, decocts twice, herbal medicine is added every time The water of 8 times of amounts of total amount, heating is decocted, and micro-boiling 30min is kept after boiling, and filtering merges the filtrate obtained by decoction, produces soup Agent.
Embodiment 2
The present embodiment provides a kind of medicament with the malicious effect of fire row of dispelling, and the medicament is made by following drugs:
Treebine stem 43g, Linear Leaf Speedwell 32g, cordate houttuynia 36g, pen grass 16g, Chinese lantern 26g, Mao Xu Cao 26g, Asiatic plantain 26g, And tassel flower 19g.
The preparation method of the medicament includes:
Herbal medicine mixing during said medicine is formulated, and mixed with the water of 10 times of amounts of herbal medicine total amount, after immersion 40min, adopt Extracted, that is, decocted twice with decocting method, keep micro-boiling 20min after boiling every time, filtering merges the filter obtained by decoction Liquid, produces decoction.
Embodiment 3
The present embodiment provides a kind of medicament with the malicious effect of fire row of dispelling, and the medicament is made by following drugs:
Treebine stem 41g, Linear Leaf Speedwell 33g, cordate houttuynia 35g, pen grass 18g, Chinese lantern 26g, Mao Xu Cao 28g, Asiatic plantain 28g, And tassel flower 16g.
The preparation method of the medicament includes:
After each herbal medicine drying and crushing to 20 mesh during said medicine is formulated, mixing, using 60% ethanol as extraction solution, Extracted using heating and refluxing extraction method, heating-up temperature is 80 DEG C, extraction time is 1.5h, after extraction, filtering, by the dregs of a decoction according to same Method is extracted again;Merge the filtrate obtained by extracting twice, be concentrated under reduced pressure after removing solvent, produce.
Embodiment 4
The present embodiment provides a kind of medicament with the malicious effect of fire row of dispelling, and the medicament is made by following drugs:
Treebine stem 40g, Linear Leaf Speedwell 34g, cordate houttuynia 34g, pen grass 17g, Chinese lantern 27g, Mao Xu Cao 27g, Asiatic plantain 27g, And tassel flower 17g.
The preparation method of the medicament includes:
After each herbal medicine drying and crushing to 4 mesh during said medicine is formulated, mixing, using 70% ethanol as extraction solution, Extracted using heating and refluxing extraction method, heating-up temperature is 75 DEG C, extraction time is 2h, after extraction, filtering, by the dregs of a decoction according to same method Extract again;Merge the filtrate obtained by extracting twice, be concentrated under reduced pressure after removing solvent, produce.
Embodiment 5
The present embodiment provides a kind of medicament with the malicious effect of fire row of dispelling, and the medicament is made by following drugs:
Treebine stem 39g, Linear Leaf Speedwell 35g, cordate houttuynia 32g, pen grass 16g, Chinese lantern 28g, Mao Xu Cao 26g, Asiatic plantain 26g, And tassel flower 18g.
The preparation method of the medicament includes:
After each herbal medicine drying and crushing to 10 mesh during said medicine is formulated, mixing, using 70% ethanol as extraction solution, Extracted using heating and refluxing extraction method, heating-up temperature is 70 DEG C, extraction time is 2.5h, after extraction, filtering, by the dregs of a decoction according to same Method is extracted again;Merge the filtrate obtained by extracting twice, be concentrated under reduced pressure after removing solvent, produce.
Embodiment 6
The present embodiment provides a kind of medicament with the malicious effect of fire row of dispelling, and the medicament is made by following drugs:
Treebine stem 43g, Linear Leaf Speedwell 37g, cordate houttuynia 32g, pen grass 19g, Chinese lantern 28g, Mao Xu Cao 28g, Asiatic plantain 29g, And tassel flower 16g.
The preparation method of the medicament includes:
After each herbal medicine drying and crushing to 10 mesh during said medicine is formulated, mixing, using 70% ethanol as extraction solution, Extracted using heating and refluxing extraction method, heating-up temperature is 70 DEG C, extraction time is 2.5h.After extraction, filtering, by the dregs of a decoction according to same Method is extracted again;Merge the filtrate obtained by extracting twice, it is 1.2 to be concentrated under reduced pressure into relative density, is produced.
Embodiment 7
The present embodiment provides a kind of medicament with the malicious effect of fire row of dispelling, and the medicament is made by following drugs:
Treebine stem 35g, Linear Leaf Speedwell 30g, cordate houttuynia 37g, pen grass 15g, Chinese lantern 25g, Mao Xu Cao 30g, Asiatic plantain 30g, And tassel flower 15g.
The preparation method of the medicament includes:
After each herbal medicine drying and crushing to 10 mesh during said medicine is formulated, mixing, using 60% methanol as extraction solution, 6h is extracted using percolation, filtering is concentrated under reduced pressure after removing solvent, produced.
Experimental example
Effect of the medicament provided with reference to clinical test the embodiment of the present invention 1~7 in terms of high fever symptom is improved Evaluated.
First, testing program
1. case selection:
This group of case be because getting angry, the high fever patient caused by inflammation, and the body temperature of patient is all higher than 39 DEG C, meets and receives Enter, exclusion standard, age 5-62 Sui, average 37 years old.8 groups are randomly divided into, every group each 20, wherein experimental group is the 1st~7 group, Control group is the 8th group.There was no significant difference for the data such as age, sex, the state of an illness of this 8 groups of patients, with comparativity.
2. therapeutic scheme:
The medicament that 1st~5 group of (experimental group) patient is provided using embodiment 1~7 respectively, daily three times, every time The dose taken is 2.5g medicinal materials/kg body weight.7th group of patient takes paracetamol, daily three times, each taking 0.4g。
Observe and observe the state of an illness after recording medication 1 day, and according to " effect is notable ", " effective ", engineering noise, " deterioration " this four Individual grade is evaluated come the therapeutic action to the medicament.
3. clinical evaluation standard:
Effect is notable:After dispenser after 6h, temperature recovery is normal, and the cold symptoms such as adjoint dizziness, nasal obstruction disappear.
Effectively:After dispenser after 6h, body temperature is down to less than 38 DEG C, and the cold symptoms such as adjoint dizziness, nasal obstruction mitigate, and continues to take After medicine 12h, temperature recovery is normal.
It is invalid:After dispenser 1 day, body temperature is constant, still maintains more than 39 DEG C, and other symptoms are not eased.
Deteriorate:After dispenser 1 day, body temperature has the trend further gone up, and other exacerbation of symptoms.
2nd, result of the test:
As shown in table 1:
The clinical test results of table 1.
Project Effect is significantly (example) Effectively (example) Invalid (example) Deteriorate (example)
Embodiment 1 16 4 0 0
Embodiment 2 17 3 0 0
Embodiment 3 17 3 0 0
Embodiment 4 19 1 0 0
Embodiment 5 18 2 0 0
Embodiment 6 17 3 0 0
Embodiment 7 16 4 0 0
Control group 2 14 4 0
As shown in Table 1:
This medicament that embodiment of the present invention is provided, shows to the therapeutic effect because of the high fever patient caused by excessive internal heat, inflammation Write, be mainly manifested in:After the medicament is applied, most of patient is after dispenser 6h, and temperature recovery is normal, adjoint head The cold symptoms such as dizzy, nasal obstruction disappear;And only small part patient, after dispenser 6h, body temperature is down to less than 38 DEG C, adjoint head The cold symptoms such as dizzy, nasal obstruction mitigate, and continue after medication 12h, patient body situation can be recovered to normal.It is (right compared to control group Paracetamol), the effect of bringing down a fever for this medicament that the embodiment of the present invention 1~7 is provided is notable.
Model case:
Case one
Lee, man, 6 years old, 39 DEG C of high fever continued two days, takes brufen, paracetamol, aspirin etc. and moves back Burn medicine invalid, also invalid in hospital transfusion, after the decoction 2h for taking the offer of the embodiment of the present invention 1, temperature recovery is normal.
Case two
Zhang, difficult, 15 years old, diseases caused by external factors ailment said due to cold or exposure was afraid of the wind all the year round to blow, weak, continuously took the decoction of the offer of the embodiment of the present invention 1 After one week, physical function recovers normal.
Case three
Field, man, 40 years old, fiery poison was made a psychological attack, aphthae, and irritability of having a sleepless night, the state of mind is sleepy.Patient's oral account continuously insomnia one Wheat harvesting period, continuously takes the decoction of the offer of the embodiment of the present invention 1 after 3 days, fast and sleep quality of falling asleep is high.
Case four
Mr. Wang, female, 34 years old, heavy cold patient, symptoms include:Fever, rhinorrhea, dizziness.Continuously the embodiment of the present invention 1 is taken to carry The decoction of confession is after 2 days, and cold symptoms disappear, and condition recovers normal.
Case five
Zhao, female, 42 years old, there is suppuration symptom in throat inflammation, and hospital doctor suggestion pricker takes purulence.Take the present invention The decoction that embodiment 1 is provided is after 1 day, useless fellow rupture, fester discharge;Continue to take the decoction of the offer of the embodiment of the present invention 12 days Afterwards, throat inflammation symptom disappears.
Although illustrate and describing the present invention with specific embodiment, but it will be appreciated that without departing substantially from the present invention's Many other changes and modification can be made in the case of spirit and scope.It is, therefore, intended that in the following claims Including belonging to all such changes and modifications in the scope of the invention.

Claims (10)

1. a kind of pharmaceutical formulation with the malicious effect of fire row of dispelling, it is characterised in that the pharmaceutical formulation count by weight including:
35~45 parts of treebine stem, 30~38 parts of Linear Leaf Speedwell, 15~20 parts of 30~37 part, grass of cordate houttuynia, 25~30 parts of Chinese lantern, 15~20 parts of 25~30 parts of Mao Xu Cao, 25~30 parts of Asiatic plantain and tassel flower.
2. the pharmaceutical formulation according to claim 1 with the malicious effect of fire row of dispelling, it is characterised in that count by weight, 37~43 parts of the treebine stem, 32~37 parts of the Linear Leaf Speedwell, 32~36 parts of the cordate houttuynia, 16~19 parts of the pen grass, institute State 26~28 parts of Chinese lantern, 26~28 parts of the Mao Xu Cao, 26~29 parts of the Asiatic plantain and the tassel flower 16~19 Part.
3. the pharmaceutical formulation according to claim 1 with the malicious effect of fire row of dispelling, it is characterised in that count by weight, 39~41 parts of the treebine stem, 33~35 parts of the Linear Leaf Speedwell, 32~35 parts of the cordate houttuynia, 16~18 parts of the pen grass, institute State 26~28 parts of Chinese lantern, 26~28 parts of the Mao Xu Cao, 26~28 parts of the Asiatic plantain and the tassel flower 16~18 Part.
4. the pharmaceutical formulation according to claim 1 with the malicious effect of fire row of dispelling, it is characterised in that count by weight, It is 40 parts of the treebine stem, 34 parts of the Linear Leaf Speedwell, 34 parts of the cordate houttuynia, 17 parts of pen grass, 27 parts of the Chinese lantern, described 17 parts of 27 parts of Mao Xu Cao, 27 parts of the Asiatic plantain and the tassel flower.
5. a kind of medicament with the malicious effect of fire row of dispelling, it is characterised in that the medicament is as described in any one of Claims 1 to 4 Pharmaceutical formulation be made.
6. the medicament according to claim 5 with the malicious effect of fire row of dispelling, it is characterised in that the formulation of the medicament includes Any one in decoction, pill, powder, tablet, capsule, pulvis and granule.
7. a kind of preparation method of the medicament as claimed in claim 5 with the malicious effect of fire row of dispelling, it is characterised in that it is wrapped Include:Herbal medicine in the pharmaceutical formulation is mixed, extracted using solvent extraction method.
8. the preparation method of the medicament according to claim 7 with the malicious effect of fire row of dispelling, it is characterised in that the solvent Extraction method includes:Any one in decocting method, percolation, heating and refluxing extraction method and infusion method.
9. the preparation method of the medicament according to claim 7 with the malicious effect of fire row of dispelling, it is characterised in that the solvent Extraction method is heating and refluxing extraction method, and the Extraction solvent in the heating and refluxing extraction method is the second that volume fraction is 60~80% Alcoholic solution, heating-up temperature are 70~80 DEG C, extraction time is 1.5~2.5h.
10. a kind of medicament as described in claim 5 or 6 is preparing the medicine of prevention or treatment anemopyretic cold, pharyngitis or air conditioner disease Purposes in thing.
CN201710496271.4A 2017-06-26 2017-06-26 A kind of medicament and its pharmaceutical formulation and preparation method with the malicious effect of fire row of dispelling Pending CN107095977A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114848743A (en) * 2022-03-16 2022-08-05 郭余 Quick-acting cold medicine and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070082076A1 (en) * 2005-10-12 2007-04-12 Spencer Feldman Glutathione and coffee suppository
CN106266568A (en) * 2016-09-18 2017-01-04 蒋丽红 A kind of health-care cold tea electuary and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070082076A1 (en) * 2005-10-12 2007-04-12 Spencer Feldman Glutathione and coffee suppository
CN106266568A (en) * 2016-09-18 2017-01-04 蒋丽红 A kind of health-care cold tea electuary and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114848743A (en) * 2022-03-16 2022-08-05 郭余 Quick-acting cold medicine and preparation method thereof
CN114848743B (en) * 2022-03-16 2023-08-08 郭余 Quick-acting medicine for treating common cold and its preparation method

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Application publication date: 20170829