CN100577195C

CN100577195C - Application of Chinese medicine composiiton in preparing medicine for treating salpingitis, oophoritic cyst, colpitis and cervicitis

Info

Publication number: CN100577195C
Application number: CN200610168335A
Authority: CN
Inventors: 王延岭; 候建平
Original assignee: SHAANXI SIZHUANG PHARMACEUTICAL CO Ltd
Current assignee: Shaanxi Kanghui Pharmaceutical Co Ltd
Priority date: 2006-12-26
Filing date: 2006-12-26
Publication date: 2010-01-06
Anticipated expiration: 2026-12-26
Also published as: CN1977939A

Abstract

The present invention relates to a medicine composition for curing gynecopathy. Said medicine composition is made by using 9 Chinese medicinal materials of red peony root, lindera root, cyperus root, flavescent sophora root, anomalous artemisia and others through a certain preparation process. Said medicine composition can be used for curing the diseases of pelvic inflammation, oophoritic cyst, vaginitis, cervicitis and annexitis, etc.

Description

The application of a kind of Chinese medicine composition in preparation treatment adnexitis, ovarian cyst, vaginitis and cervicitis medicine

Technical field

The present invention relates to a kind of preparation method for the treatment of the medicine of gynaecopathia, specifically is the method for making that is used for the treatment of the Chinese medicine composition of symptoms such as pelvic inflammatory disease, ovarian cyst, vaginitis, cervicitis, adnexitis.

Background technology

In recent years, the sickness rate of gynaecopathia is ascendant trend year by year, particularly pelvic inflammatory disease, comprises ovarian cyst, vaginitis, cervicitis, adnexitis, is common gynecological disease, frequently-occurring disease, also is difficult and complicated illness.Aspect treatment, doctor trained in Western medicine adopts antibiosis to have certain effect, but prolonged application not only directly reduces the infection curative effect, also can cause bacterial resistance, untoward reaction also can occur and add heavy patient's financial burden.

For this reason, modern medicine is devoted to study the Chinese medicine preparation that has no side effect.Commercially available Chinese medicine is based on the Kunfukang capsule, and it has alleviated the puzzlement for pelvic inflammatory disease patient due to qi depression to blood stasis, the damp-heat accumulation to a certain extent, and its main component is: Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi, Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae ， Herba Polygoni Avicularis, Polyporus, Fructus Ligustri Lucidi.Its function cures mainly: blood circulation promoting and blood stasis dispelling, eliminating damp-heat.Be used for qi depression to blood stasis, the pelvic inflammatory disease of damp-heat accumulation, disease is seen profuse leukorrhea, diseases such as hypogastralgia.Its usage and dosage: oral, a 3-4 grain, 3 times on the one.But because its suitable disease is narrow, dosage form is single and effective ingredient utilization rate deficiency, so can't satisfy patient's demand.

Summary of the invention

Purpose of the present invention just is to work out a kind of preparation method for the treatment of the Chinese medicine composition of gynaecopathia, overcome above-mentioned the deficiencies in the prior art, and provide a kind of utilization rate, expansion that improves effective ingredient to use the drug and patient group, and increase new indication, improve the method for making of the Chinese medicine composition of curative effect.The Chinese medicine composition of preparing with method of the present invention can be prepared into different dosage form at needs of patients in addition, is convenient to take, and is easy to carry.

The present invention adopts orthogonal test to carry out preferred Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae ， Herba Polygoni Avicularis, Polyporus, amount of water, extraction time, extraction time that Fructus Ligustri Lucidi Six-element medical material decocts with water.Through orthogonal test screening, studies confirm that add water 6-12 and doubly measure and decoct 3 times, each 1-2 hour, it is bigger that decocting goes out the medicine compositional polarity, especially with the first time amount of water be 10 times of amounts, the decoction 2 hours of Six-element medical material mixture; For the second time amount of water is 8 times of amounts, the decoction 2 hours of Six-element medical material mixture; For the third time amount of water be Six-element medical material mixture 8 times of amounts, decoct 1 hour for good, to go out the medicine compositional polarity bigger for decocting under this condition, has stronger physiologically active, makes them give play to the main effective ingredient of maximum drug effect.

The fine powder and the Radix Sophorae Flavescentis of Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi three flavor medicines, Artemisia anomah S. Moore Rhizoma Dioscoreae Hypoglaucae ， Herba Polygoni Avicularis, Polyporus, the thick paste that Fructus Ligustri Lucidi Six-element medical material is condensed into mixes, take cold drying, test 40-60 ℃ of preferred cold drying temperature, avoid scattering and disappearing of the Radix Linderae, Rhizoma Cyperi volatile oil, the reduction of peoniflorin composition in the Radix Paeoniae Rubra guarantees curative effect of medication.

The present invention is formed by the following raw medicaments in portion by weight processing and preparing:

Radix Paeoniae Rubra 68-110 part, Radix Linderae 68-110 part, Rhizoma Cyperi 68-110 part, Radix Sophorae Flavescentis 68-110 part, Artemisia anomah S. Moore 68-110 part, Rhizoma Dioscoreae Hypoglaucae 68-110 Fen ， Herba Polygoni Avicularis 68-110 part, Polyporus 85-170 part, Fructus Ligustri Lucidi 68-136 part; Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi are pulverized, cross 150 orders-300 mesh sieve, form the micropowder of three kinds of medical materials; With Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae ， Herba Polygoni Avicularis, Polyporus, the mixture of Fructus Ligustri Lucidi Six-element medical material decocts with water, and collecting decoction filters, and filtrate decompression is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃); In thick paste, add Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi fine powder after pulverizing, mixing, cold drying under 40-60 ℃ temperature is ground into the micropowder that particle diameter is 0.5-40 μ m, and mixing gets active constituents of medicine, is prepared from a kind of Chinese medicine composition for the treatment of gynaecopathia.

Preferably, Radix Paeoniae Rubra 88-110 part, Radix Linderae 88-110 part, Rhizoma Cyperi 88-110 part, Radix Sophorae Flavescentis 88-110 part, Artemisia anomah S. Moore 88-110 part, Rhizoma Dioscoreae Hypoglaucae 88-110 Fen ， Herba Polygoni Avicularis 88-110 part, Polyporus 85-130 part, Fructus Ligustri Lucidi 68-109 part; Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi are pulverized, cross 180 orders-300 mesh sieve, form the micropowder of three kinds of medical materials; With Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae ， Herba Polygoni Avicularis, Polyporus, the mixture of Fructus Ligustri Lucidi Six-element medical material decocts with water, and collecting decoction filters, and filtrate decompression is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃); In thick paste, add Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi fine powder after pulverizing, mixing, cold drying under 40-60 ℃ temperature is ground into the micropowder that particle diameter is 0.5-40 μ m, and mixing gets active constituents of medicine, is prepared from a kind of Chinese medicine composition for the treatment of gynaecopathia.

Preferred again, 87 parts of Radix Paeoniae Rubra, 87 parts of the Radixs Linderae, 87 parts of Rhizoma Cyperis, 87 parts of Radix Sophorae Flavescentiss, 87 parts of Artemisia anomah S. Moores, 87 parts of Rhizoma Dioscoreae Hypoglaucae 87 Fen ， Herba Polygoni Avicularis, 131 parts of Polyporus, 110 parts of Fructus Ligustri Lucidi; Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi are pulverized, cross 200 mesh sieves, form the micropowder of three kinds of medical materials; With Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae ， Herba Polygoni Avicularis, Polyporus, the mixture of Fructus Ligustri Lucidi Six-element medical material decocts with water, and collecting decoction filters, and filtrate decompression is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃); In thick paste, add Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi fine powder after pulverizing, mixing, cold drying under 40-60 ℃ temperature is ground into the micropowder that particle diameter is 0.5-40 μ m, and mixing gets active constituents of medicine, is prepared from a kind of Chinese medicine composition for the treatment of gynaecopathia.

Preferred, 100 parts of Radix Paeoniae Rubra, 100 parts of the Radixs Linderae, 100 parts of Rhizoma Cyperis, 100 parts of Radix Sophorae Flavescentiss, 100 parts of Artemisia anomah S. Moores, 100 parts of Rhizoma Dioscoreae Hypoglaucae 100 Fen ， Herba Polygoni Avicularis, 85 parts of Polyporus, 68 parts of Fructus Ligustri Lucidi; Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi are pulverized, cross 200 mesh sieves, form the micropowder of three kinds of medical materials; With Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae ， Herba Polygoni Avicularis, Polyporus, the mixture of Fructus Ligustri Lucidi Six-element medical material decocts with water, and collecting decoction filters, and filtrate decompression is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃); In thick paste, add Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi fine powder after pulverizing, mixing, cold drying under 40-60 ℃ temperature is ground into the micropowder that particle diameter is 0.5-40 μ m, and mixing gets active constituents of medicine, is prepared from a kind of Chinese medicine composition for the treatment of gynaecopathia.

The present invention can be prepared into tablet, granule, pill, capsule; Can preparation tablets be become coated tablet, vaginal tablet, effervescent tablet according to needs of patients; Granule is prepared into contains sugared granule, sugar free granule; Pill is prepared into the watered pill, water-honeyed pill, big honeyed pills.

Described weight portion can be weight metering units such as gram, two, jin, kilogram, ton.

Nine used flavor medical materials are the Chinese crude drug that commercially available process is up to the standards.

The preparation method of Chinese medicine composition of the present invention comprises the steps:

(1) Radix Paeoniae Rubra 68-110 part, Radix Linderae 68-110 part, Rhizoma Cyperi 68-110 part, Radix Sophorae Flavescentis 68-110 part, Artemisia anomah S. Moore 68-110 part, Rhizoma Dioscoreae Hypoglaucae 68-110 Fen, Herba Polygoni Avicularis 68-110 part, Polyporus 85-170 part, the Fructus Ligustri Lucidi 68-136 part of getting is by weight cleaned, and is standby;

(2) Radix Paeoniae Rubra is cut into the 2-3mm sheet, the Radix Linderae is cut into 0.2-2mm sheet, Rhizoma Cyperi fragmentation, Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi is mixed pulverize, and crosses the 150-300 mesh sieve, mixing; The mixture of Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae, Herba Polygoni Avicularis, Polyporus, Fructus Ligustri Lucidi Six-element medical material is decocted with water, and collecting decoction filters, and filtrate decompression is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃);

(3) Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi medicated powder after adding is pulverized in thick paste, mixing carries out cold drying under 40 ℃-60 ℃ temperature, be ground into the micropowder that particle diameter is 0.5-40 μ m, and mixing promptly gets active constituents of medicine.

Preferred version, step is as follows:

(1) Radix Paeoniae Rubra 88-110 part, Radix Linderae 88-110 part, Rhizoma Cyperi 88-110 part, Radix Sophorae Flavescentis 88-110 part, Artemisia anomah S. Moore 88-110 part, Rhizoma Dioscoreae Hypoglaucae 88-110 Fen, Herba Polygoni Avicularis 88-110 part, Polyporus 85-130 part, the Fructus Ligustri Lucidi 68-109 part of getting is by weight cleaned, and is standby;

(2) Radix Paeoniae Rubra is cut into the 2-3mm sheet, the Radix Linderae is cut into 0.2-2mm sheet, Rhizoma Cyperi fragmentation, and Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi are pulverized, and crosses the 150-300 mesh sieve, mixing; The mixture of Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae, Herba Polygoni Avicularis, Polyporus, Fructus Ligustri Lucidi Six-element medical material is decocted with water, and collecting decoction filters, and filtrate decompression is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃);

Preferred version again, step is as follows:

(1) 87 parts of 87 parts of 87 parts of 87 parts of 87 parts of Radix Paeoniae Rubra, the Radixs Linderae, Rhizoma Cyperis, Radix Sophorae Flavescentiss, Artemisia anomah S. Moores, Rhizoma Dioscoreae Hypoglaucae 87 87 parts of Fen, Herba Polygoni Avicularis, 131 parts of Polyporus, the Fructus Ligustri Lucidi of getting by weight cleaned for 110 parts, and be standby;

(2) Radix Paeoniae Rubra is cut into the 2-3mm sheet, the Radix Linderae is cut into 0.2-2mm sheet, Rhizoma Cyperi fragmentation, and Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi are pulverized, and crosses 200 mesh sieves, mixing; The mixture of Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae, Herba Polygoni Avicularis, Polyporus, Fructus Ligustri Lucidi Six-element medical material is decocted with water, and collecting decoction filters, and filtrate decompression is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃);

Scheme most preferably, step is as follows:

(1) 100 parts of 100 parts of 100 parts of 100 parts of 100 parts of Radix Paeoniae Rubra, the Radixs Linderae, Rhizoma Cyperis, Radix Sophorae Flavescentiss, Artemisia anomah S. Moores, Rhizoma Dioscoreae Hypoglaucae 100 100 parts of Fen, Herba Polygoni Avicularis, 85 parts of Polyporus, the Fructus Ligustri Lucidi of getting by weight cleaned for 68 parts, and be standby;

The condition that decocting boils is, decocts with water 3 times, and the 6-12 that each amount of water is Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae, Herba Polygoni Avicularis, Polyporus, Fructus Ligustri Lucidi Six-element medical material mixture doubly each 1-3 hour, decocts temperature and is controlled at 80 ℃ to boiling; Again with the first time amount of water be Six-element medical material mixture 10 times of amounts, decocted 2 hours; For the second time amount of water is 8 times of amounts, the decoction 2 hours of Six-element medical material mixture; For the third time amount of water be Six-element medical material mixture 8 times of amounts, decocted 1 hour, decoct temperature and be 100 ℃ for good.

In active constituents of medicine, add adjuvant, mixing, tabletting is prepared into tablet; Tablet can be prepared into coated tablet, vaginal tablet and effervescent tablet as required.

Add adjuvant in active constituents of medicine, mixing is granulated, drying, and packing is prepared into granule; Granule can be prepared into as required and contain sugared granule and sugar free granule.

Add adjuvant in active constituents of medicine, mixing is prepared into pill; Can be prepared into the watered pill, water-honeyed pill and big honeyed pills as required.

In active constituents of medicine, add adjuvant, mixing, drying, encapsulated, be prepared into capsule.

The preparation method of tablet is that it is clean, standby to get crude drug by the weight portion of each component; With Radix Paeoniae Rubra be cut into the 2-3mm sheet, the Radix Linderae is cut into 0.2-2mm sheet, Rhizoma Cyperi fragmentation, and Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi are pulverized, and crosses 200 mesh sieves, mixing; The mixture of Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae, Herba Polygoni Avicularis, Polyporus, Fructus Ligustri Lucidi Six-element medical material is decocted with water, and collecting decoction filters, and filtrate decompression is concentrated into the thick paste that relative density is 1.25-1.30 (60 ℃); In thick paste, add Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi medicated powder after pulverizing, mixing, cold drying is ground into the micropowder that particle diameter is 0.5-40 μ m, and mixing promptly gets active constituents of medicine.Add low-substituted hydroxypropyl cellulose in active constituents of medicine, consumption is the 2-3% of active constituents of medicine amount, granulates, and carries out cold drying under 40-60 ℃, granulate adds magnesium stearate, and consumption is 0.3～0.8% of an active constituents of medicine amount, mixing, tabletting makes tablet.

The preparation method of coated tablet is, is same as the preparation method of tablet substantially, and having only different is that coating makes coated tablet behind the tabletting.

The preparation method of vaginal tablet is, substantially be same as the preparation method of tablet, have only and different be, in active constituents of medicine, add microcrystalline Cellulose, pregelatinized Starch, hydroxypropyl cellulose, consumption is the 2-3% of active constituents of medicine weight, granulates, and temperature is controlled at 40-60 ℃ and carries out cold drying, with silicon dioxide, magnesium stearate mixing, tabletting makes vaginal tablet.

The preparation method of effervescent tablet is, is same as the preparation method of tablet substantially, has only different to be, obtain active constituents of medicine after, with 95% ethanol 4-6L dissolving Polyethylene Glycol, 1～2L, in lysate, add sodium bicarbonate 1～2L again, it is standby to make mixed liquor; With spray starch absorption dehydration method mixed liquor is sprayed in the spray-drying pelleting machine in splendid attire active constituents of medicine and starch (PGL-80 type, the wide summer of Chongqing, drying equipment engineering company produced) and to carry out drying and granulating, cross the 10-30 mesh sieve, granulate; Citric acid is crossed the granule of 10-30 mesh sieve, granule and fumaric acid fine powder mix homogeneously behind the granulate, and tabletting makes effervescent tablet.Wherein inlet temperature is controlled at 75-95 ℃, and temperature of charge is controlled at 70-90 ℃, and atomisation pressure is 0.1-0.3Mpa, and the transfusion frequency is 10-40r/min, and amount of starch is the 2.5-3.5% of active constituents of medicine in the spray-drying pelleting machine.

The preparation method that contains sugared granule is, substantially be same as the preparation method of coated tablet, having only different is to add sucrose 1-3 part and dextrin 1-2 part in active constituents of medicine, mixing, the ethanol that adds the 60-75% percentage by weight is done binding agent, granulates, and carries out cold drying under 40-60 ℃ temperature, granulate, cross the 10-30 mesh sieve, packing promptly gets granule.

The preparation method of sugar free granule is, is same as the preparation method that contains sugared granule substantially, and having only different is only to add dextrin 1-2 part in active constituents of medicine.

The preparation method of the watered pill is, is same as the preparation method of tablet substantially, has only different to be, adds entry in the watered pill machine that active constituents of medicine is housed, and uses water pill, and is dry under 40-60 ℃ temperature, promptly gets the watered pill.

The preparation method of water-honeyed pill is, is same as the preparation method of tablet substantially, and having only different is to add refined honey in active constituents of medicine, consumption is the 35%-50% of active constituents of medicine amount, and reuse water is used water pill as extracting solvent,, dry under 40-60 ℃ temperature, make water-honeyed pill.

The preparation method of big honeyed pills is, is same as the preparation method of water-honeyed pill substantially, has only different to be, adds refined honey in active constituents of medicine, and consumption is the 100%-120% of active constituents of medicine amount, makes big honeyed pills.

The preparation method of capsule is, is same as the preparation method of tablet substantially, has only different to be, it is an amount of to add supplementary product starch in active constituents of medicine, and consumption is the 1.0-3.0% of active constituents of medicine amount, granulates, and dresses up capsule, makes capsule.

Why the present invention selects for use above-mentioned medical material as raw material, is because they have following effect:

Radix Paeoniae Rubra: clots absorbing, pain relieving, removing heat from blood, detumescence.Control the stagnant amenorrhea of the stasis of blood, the hernia abdominal mass is gathered, stomachache ... blood La, conjunctival congestion, carbuncle.

" not Lu ": " clear and coherent blood vessels, slow in, dispelling malignant blood, expelling extravasated blood, the gas that anhydrates, sharp bladder intestine and small intestine, subduing inflammation, the time row cold and heat, attacked by pestiferous factors stomachache, lumbago.”

The Radix Linderae: pleasant, dissipating depression of QI, cold expelling, pain relieving.Control the QI rising in reverse order chest and abdomen swelling and pain, dyspepsia does not disappear, and food is told in regurgitation, colic of cold type, beriberi, frequent micturition.

" detailed outline ": " control middle gas, beriberi, hernia, emotional headache, swelling is panted, and ends frequent micturition and nebulousurine.”

Rhizoma Cyperi is a sedge dried tuber Cyperus rotundus L. rhizome.The property flat, acrid in the mouth, little sweet, little hardship, it is vexed to have promoting QI circulation for relieving depression, the effect of menstruction regulating and pain relieving.

Radix Sophorae Flavescentis, heat clearing away, dampness, parasite killing.Control toxic-heat and blood stasis, discharging fresh blood stool, jaundice, leucorrhea with red and white discharge ...

" property of medicine opinion ": " control pyretic toxicity wind, the irritated skin ulcer of giving birth to of musculus cutaneus, red leprosy eyebrow takes off, and is main drowsiness except that big heat, controls cold type of pain in the abdomen, attacked by pestiferous factors stomachache, it is vexed to remove body, controls the trusted subordinate and gathers.”

Artemisia anomah S. Moore, removing blood stasis stimulates the menstrual flow, healing up sore and subduing swelling.Control amenorrhea and mass in the abdomen, chest and abdomen swelling and pain, puerperal blood stasis, traumatic injury, incised wound is hemorrhage, Yong Du burning swelling.

" Japan hanako materia medica ": " control cardiac and abdominal pain, therapeutic method to keep the adverse QI flowing downwards watery distension, vim and vigour, logical married woman Jing Mai Disorder knot ends the cholera watery diarrhea.”

Rhizoma Dioscoreae Septemlobae dispels the wind, dampness removing.The dispelling the wind and dampness pathogens insensitive impediment, lumbocrural pain, dysuria, stranguria with turbid discharge, seminal emission, damp and hot sore.

" the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control wind and cold, the warming the meridian network, the waist knee joint is painful, stupid fiber crops all over, sharp bladder water channel, red white turbid urine.”

Herba Polygoni Avicularis, diuresis, heat clearing away, parasite killing.Control pyretic stranguria, the difficulty in urination, jaundice, the erosion of the vulva, leucorrhea ...

" the southern regions of the Yunnan Province book on Chinese herbal medicine ": " diuresis.Control the five types of stranguria nebulousurine, pyretic stranguria, the smart puckery key that closes the border of the stasis of blood, and control married woman's stagnation of QI, damp and hot in the stomach, or the disease of leucorrhea.”

Polyporus, the diuresis eliminating dampness by diuresis.Control dysuria, the edema distension, beriberi is had loose bowels, pouring, turbid, leukorrhagia.

Fructus Ligustri Lucidi, invigorating the liver and kidney, strong waist knee joint.Control interior-heat caused by deficiency of YIN, dizziness, order flower, tinnitus, soreness of the waist and knees, early whitening of beard and hair.

The present invention has blood circulation promoting and blood stasis dispelling, eliminating damp-heat effect.Not only be used for qi depression to blood stasis, the pelvic inflammatory disease of damp-heat accumulation, disease is seen profuse leukorrhea, diseases such as hypogastralgia have better curative effect, and for gynecological inflammations such as chronic pelvic inflammatory disease, ovarian cyst, vaginitis, cervicitis, adnexitis significant curative effect are arranged all.The usage and dosage of coated tablet is oral, every day 3 times, each 3; The usage and dosage of vaginal tablet is a vagina usefulness, every day 1 time, each 1; The usage and dosage of effervescent tablet is oral, every day 3 times, each 3; The usage and dosage that contains sugared granule is that boiled water is taken after mixing it with water, every day 3 times, each 9g; The usage and dosage of sugar free granule is that boiled water is taken after mixing it with water, every day 3 times, each 3g; The usage and dosage of the watered pill is oral, every day 3 times, each 3 balls; The usage and dosage of water-honeyed pill is oral, every day 3 times, each 3 balls; The usage and dosage of big honeyed pills is oral, every day 3 times, each 3 balls; The usage and dosage of capsule is oral, 3 times on the one, one time 3.

For curative effect of the present invention is described, the applicant carries out pharmacodynamics test to it, and the result is as follows:

One, the analgesic activity of medicine of the present invention

1, hot plate method

Get female ICR mice, body weight 20-23g selects the threshold of pain (55 ° ± 1 ℃) and is 50 of 5-30 person'ss second, and ig gives active constituents of medicine 0.2g/kg, 0.8g/kg, 2.0g/kg (making under the equal-volume suspension same) respectively, another group subcutaneous injection 20mg/kg piperazine

The pain threshold of 20min, 40min after its administration, 60min, 80min is surveyed in pyridine respectively, the results are shown in Table 1:

Table 1 medicine of the present invention is to the influence of the mice threshold of pain

^*P＜0.05 (with the matched group ratio)

2, writhing method

Get 49 of ICR mices, body weight 18-22g, male and female are regardless of, and the grouping administration is the same, behind the administration 30min, gives each Mus ip0.6% acetic acid solution 0.2ml/ only respectively, observes and write down to turn round the body number of times in its 20min, the results are shown in Table 2.

Table 2 pair writhing response influence X ± S

^*P＜0.05 ^**P＜0.01

Two, medicine of the present invention is to the influence of clotting time of mice

Get ICR mice male and female and be regardless of, body weight 18-22g, the grouping administration is the same, and administration 4 days behind last administration 30min, is got blood and is surveyed its clotting time with slide method, the results are shown in Table 3.

The influence of table 3 pair clotting time of mice

Three, medicine of the present invention is to the influence of mouse dimethylbenzene ear expanding

Get 50 of ICR mices, male and female are regardless of, body weight 18-22g, and all the other each component group administrations are the same except that positive control is used indometacin (20mg/kg), administration three days, last administration 30min is coated with 0.05ml dimethylbenzene for respectively each Mus auris dextra, is coated with back 15min and cuts ear, punching, weigh, represent its swelling degree, the results are shown in Table 4 with the difference of left and right sides auricle weight.

The influence of table 4 pair mouse dimethylbenzene ear expanding

^*P＜0.05 ^**P＜0.01

Four, medicine of the present invention influences the mouse peritoneal capillary permeability

Get female ICR mice, body weight 18-22g, the grouping administration is the same, and administration 4 days is behind last administration 30min, tail vein injection 2% azovan blue solution 0.1ml/ only, ip0.6% acetum 0.2ml/ only puts to death behind the 20min with 5ml distilled water flushing abdominal cavity simultaneously, draws flushing liquor 4.5ml, the centrifugal 5min of 1000 commentaries on classics/min gets supernatant and the results are shown in Table 5 in 590nm place its OD value of survey on 721 spectrophotometer.

Table 5 medicine of the present invention is to the influence of capillary permeability

^**P＜0.01

Five, medicine of the present invention is to the influence of isolated rat uterine smooth muscle

Get 5 of female sd inbred rats, body weight 200-230g, difference SC diethylstilbestrol 0.1mg/kg, put to death after two days, cut open the belly, get the long cornua uteri of Rockwell liquid clip 2cm after cornua uteri is put into logical oxygen, connect writing lever, and make trace the end lever amplify 1 times make it balance after, add 1g and load in longwell end mid point, trace normalized curve after, add active constituents of medicine 15mg/ml of the present invention successively, pituitrin 0.025mg/ml, active constituents of medicine 30.0mg/ml of the present invention observes the variation of its tension force, intensity, frequency, the results are shown in Table 6.

The influence of table 6 pair isolated rat uterine smooth muscle

^*P＜0.05 ^{* *}P＜0.001 (with just often comparing)

△ P＜0.05 △ △ △ P＜0.001 (comparing) with pituitrin

Six, the antibacterial action of medicine of the present invention

Active constituents of medicine with 85% ethanol extraction, is reclaimed ethanol, prepare 30% aqueous solution, when the tube dilution method antibacterial tests, use.

1, to colibacillary effect

Tube dilution method is got 10 in test tube, adds the meat soup of the medicinal liquid contain variable concentrations invention medicine successively, add respectively then Escherichia coli bacteria liquid 50 μ l to bacterial concentration be 9 * 10 ⁵Individual/ml, put 37 ℃ and hatch 24h, take out and observe the bacterial growth situation, the results are shown in following table.

The result shows: medicine of the present invention is 1/32 with tube dilution method to the escherichia coli minimal inhibitory concentration.

Tilt-pour process: the Kunfukang medicated powder that takes by weighing Different Weight, sterilization, add then the 25ml nutrient agar make medicine dull and stereotyped and carry out sterility test after, 37 ℃ of escherichia coli of cultivating 6h are diluted to 10-3 with meat soup, getting 0.5ml then evenly is inoculated on the medicine flat board, cultivate 24h for 37 ℃, containing the above invention active constituents of medicine of 5.2g person as a result in the 25ml agar does not all have the escherichia coli growth.

Above result shows that medicine of the present invention has the obvious suppression effect to escherichia coli.

2, to the oidiomycetic bacteriostasis of white

Agar dilution, get 10 of sterile test tube, add the sabouraud culture medium 5ml that contains the variable concentrations medicinal liquid successively and make into the inclined-plane, and after steriling test is qualified to the Candida albicans bacterium colony of each pipe dibbling Semen setariae size, hatch for 28 ℃, when treating that albicans growth is good in the control tube, read the result, the results are shown in following table.

The result shows that medicine of the present invention is 1/16 to the oidiomycetic minimal inhibitory concentration of white.

Tilt-pour process: the Kunfukang medicated powder that takes by weighing Different Weight, sterilization, add sabouraud culture medium 25ml respectively and make the medicine flat board, after sterility test is qualified, get the dibbling of Semen setariae size Candida albicans bacterium colony in medicine Sha Shi flat board, put 28 ℃ of cultivations, flat-plate bacterial colony to be contrasted is grown good back and is observed, when the result adds to 6.0g at Kunfukang medicated powder, still have the candidiasis growth.

Above result shows: medicine of the present invention has certain inhibitory action to Candida albicans.

From above experimental result, medicine of the present invention can improve the mice threshold of pain, writhing response number of times due to the minimizing acetic acid, suppress the dimethylbenzene ear swelling, reduce the abdominal cavity capillary permeability, shorten clotting time, suppress the isolated uterine wriggling, suppress escherichia coli, albicans growth, and can resist the hysterospasm contraction that pituitrin causes, show that medicine of the present invention has the effect of analgesia, antibiotic, antiinflammatory, the level and smooth convulsion flesh of hemostasis and releasing uterus contraction.

The present inventor adopts orthogonal test to carry out preferred Radix Sophorae Flavescentis, Artemisia anomah S. Moore, and Rhizoma Dioscoreae Hypoglaucae ， Herba Polygoni Avicularis, Polyporus, amount of water, extraction time, extraction time that Fructus Ligustri Lucidi Six-element medical material decocts with water, conclusion is as follows:

Under same decocting time 2h, 2h, 1h condition, different amount of water are investigated down:

Amount of water is to the influence (n=3) of extraction effect

The result shows: amount of water is many more, and extraction ratio is high more, adds 12 (10,10) times water gaging and add 10 (8,8) times water gaging to be more or less the same (0.5%), adds 8 (6,6) times water gaging and add 10 (8,8) to differ big (1.8%).And matrine content and extraction ratio have certain positive correlation, and promptly extraction ratio is high more, and matrine content is high more.Consider the principle of saving cost in the production simultaneously, select to add 10 (8,8) times water gaging and be advisable.

Under same amount of water 10 (8,8) times condition, decocting time is to the influence of extraction effect:

Amount of water is to the influence of total fried thing and chlorogenic acid content

The result shows: same amount of water condition under, different decocting times according to dried cream yield, matrine content, is considered in the production principle of saving cost simultaneously, selects to add 2 (2,1) hour decocting time and is advisable.

In order to further specify curative effect of the present invention, the inventor carries out clinical trial to the present invention, now the result is reported as follows:

One, case is selected

235 routine cases, clinic case 148 examples wherein, inpatient's 87 examples.Pelvic inflammatory disease 85 examples, vaginitis 60 examples, adnexitis 30 examples, cervicitis 28 examples, ovarian cyst 32 examples.

Two, Therapeutic Method

The outpatient was a course of treatment in 1 week, and further consultation in 5 days once and is done inspection, the record symptom and sign.Look into B ultrasonic one week one time.The drug administration method is that the effective dose of taking in a day is 4.3～4.8g.Period in a medicine is withdrawn other all medicines.

The inpatient, the effective dose of taking in a day is 4.3～4.8g.Viewing duration all medicines of stopping using, sign of three days records is done B ultrasonic one week one time.

Three, efficacy analysis:

1, the general curative effect analytical table 1

By table 1 as seen, total effective rate is 94.8%.

2, each sick total effects analytical table 2

As can be seen from the above table in the 235 routine cases, pelvic inflammatory disease 85 examples wherein, effective percentage reaches 95.6%; Adnexitis 30 examples, effective percentage reaches 93.3%; Ovarian cyst 32 examples, effective percentage 93.7%; Vaginitis 60 examples, effective percentage 95.0%; Cervicitis 28 examples, effective percentage reaches 96.4%.

3, the course of disease and therapeutic effect relationship table 3

The course of disease and therapeutic effect relationship are little as can be seen from the above table.

4, curative effect and relationship with age table 4

As can be seen from the above table, age of onset and therapeutic effect relationship are little.

According to the clinical trial method of medicine of the present invention, control drug Kunfukang capsule is carried out corresponding clinical trial, the result is as follows:

One, case is selected

This tests 117 routine cases, all derives from my gate and examines and the ward, outpatient's 89 examples wherein, inpatient's 28 examples, chronic pelvic inflammatory disease 81 examples, acute adnexitis 36 examples.

Two, method of administration

Oral drugs, 3 times on the one, one time 3, period in a medicine stop using other all medicines and Therapeutic Method.Three months is a treatment cycle.

Three, efficacy analysis

1, general curative effect analysis (seeing Table 1)

Table 1 general curative effect analytical table

By table 1 as seen, the capsular total effective rate of Kunfukang is 93.16%.

2, different sick analyses (seeing Table 2) of planting curative effect

The different sick curative effect conclusive tables 2 of planting of table 2

As can be seen from Table 2, the Kunfukang capsule is to chronic pelvic inflammatory disease effective percentage 93.83%; Acute pelvic inflammatory disease effective percentage 91.66%.

3, all ages and classes efficacy analysis (seeing Table 3)

Table 3 all ages and classes efficacy analysis

Drawn by above test, total effective rate of the present invention is 94.8%, and the capsular total effective rate of control drug Kunfukang is 93.16%; As seen, the clinical efficacy of medicine of the present invention is better than the capsular clinical efficacy of Kunfukang.

Beneficial effect of the present invention is:

(1) adopt the different dosage form sample of the preferred process conditions preparation of the present invention all to have the effect of blood circulation promoting and blood stasis dispelling, clearing away heat-damp and promoting diuresis, not only to the diarrhea due to stagnation of QI blood stasis, the pelvic inflammatory disease of damp-heat accumulation, disease is seen profuse leukorrhea, diseases such as hypogastralgia have better curative effect, and for gynecological inflammations such as chronic pelvic inflammatory disease, ovarian cyst, vaginitis, cervicitis, adnexitis significant curative effect is arranged all, enlarged and used the drug and patient group;

(2) pulverize the medicine smashing fineness thinner by experimental study; Can strengthen effective ingredient, improve bioavailability, thereby strengthen the curative effect of final drug;

(3) adopt orthogonal test screening decocting boil amount of water, extraction time, extraction time, make decocting go out the medicine compositional polarity and become big, have stronger physiologically active, improve the utilization rate of active components of medicine;

(4) adopt cold drying, avoid scattering and disappearing of the Radix Linderae, Rhizoma Cyperi volatile oil, the reduction of peoniflorin composition in the Radix Paeoniae Rubra, the curative effect of assurance medicine;

(5) drug particle size is diminished, improve the utilization rate of effective ingredient.

The specific embodiment

The following example will further specify the present invention, and embodiment should not be regarded as limiting the scope of the invention.

Embodiment 1

Used crude drug is Radix Paeoniae Rubra 100g, Radix Linderae 100g, Rhizoma Cyperi 100g, Radix Sophorae Flavescentis 100g, Artemisia anomah S. Moore 100g, Rhizoma Dioscoreae Hypoglaucae 100g, Herba Polygoni Avicularis 100g, Polyporus 85g, Fructus Ligustri Lucidi 68g in the present embodiment; Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi are pulverized, cross 200 mesh sieves, form the micropowder of three kinds of medical materials; With Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae ， Herba Polygoni Avicularis, Polyporus, the mixture of Fructus Ligustri Lucidi Six-element medical material decocts with water, and collecting decoction filters, and filtrate decompression is concentrated into the thick paste that relative density is 1.25 (60 ℃); In thick paste, add Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi fine powder after pulverizing, mixing, cold drying is ground into the micropowder that particle diameter is 0.5 μ m, and mixing gets active constituents of medicine, is prepared from a kind of Chinese medicine composition for the treatment of gynaecopathia.

Its preparation method is:

(1) crude drug of getting above-mentioned described weight is cleaned, and is standby;

(2) Radix Paeoniae Rubra is cut into the 3mm sheet, the Radix Linderae is cut into 2mm sheet, Rhizoma Cyperi fragmentation, and Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi are pulverized, and crosses 300 mesh sieves, mixing; The mixture of Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae, Herba Polygoni Avicularis, Polyporus, Fructus Ligustri Lucidi Six-element medical material is decocted with water three times, for the first time amount of water is that 10 times of mixture decocted 2 hours, for the second time amount of water is that 8 times of mixture decocted 2 hours, amount of water is 8 times of mixture and decocted 1 hour for the third time, decoct temperature and be controlled at 100 ℃, collecting decoction filters, and filtrate decompression is concentrated into the thick paste that relative density is 1.30 (60 ℃);

(3) Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi medicated powder after adding is pulverized in thick paste, mixing carries out cold drying under 60 ℃, be ground into the micropowder that particle diameter is 40 μ m, and mixing promptly gets active constituents of medicine;

(4) as required, in active constituents of medicine, add corresponding adjuvant, be prepared into corresponding dosage form.

Embodiment 2

Used crude drug is Radix Paeoniae Rubra 87g, Radix Linderae 87g, Rhizoma Cyperi 87g, Radix Sophorae Flavescentis 87g, Artemisia anomah S. Moore 87g, Rhizoma Dioscoreae Hypoglaucae 87g, Herba Polygoni Avicularis 87g, Polyporus 131g, Fructus Ligustri Lucidi 110g in the present embodiment; Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi are pulverized, cross 300 mesh sieves, form the micropowder of three kinds of medical materials; With Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae ， Herba Polygoni Avicularis, Polyporus, the mixture of Fructus Ligustri Lucidi Six-element medical material decocts with water, and collecting decoction filters, and filtrate decompression is concentrated into the thick paste that relative density is 1.30 (60 ℃); In thick paste, add Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi fine powder after pulverizing, mixing, cold drying is ground into the micropowder that particle diameter is 40 μ m, and mixing gets active constituents of medicine, is prepared from a kind of Chinese medicine composition for the treatment of gynaecopathia.

Preparation method is with embodiment 1.

Embodiment 3

Used crude drug is Radix Paeoniae Rubra 68g, Radix Linderae 68g, Rhizoma Cyperi 68g, Radix Sophorae Flavescentis 68g, Artemisia anomah S. Moore 68g, Rhizoma Dioscoreae Hypoglaucae 68g, Herba Polygoni Avicularis 68g, Polyporus 170g, Fructus Ligustri Lucidi 136g in the present embodiment; Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi are pulverized, cross 150 mesh sieves, form the micropowder of three kinds of medical materials; With Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae ， Herba Polygoni Avicularis, Polyporus, the mixture of Fructus Ligustri Lucidi Six-element medical material decocts with water, and collecting decoction filters, and filtrate decompression is concentrated into the thick paste that relative density is 1.25 (60 ℃); In thick paste, add Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi fine powder after pulverizing, mixing, cold drying is ground into the micropowder that particle diameter is 20 μ m, and mixing gets active constituents of medicine, is prepared from a kind of Chinese medicine composition for the treatment of gynaecopathia.

Preparation method is with embodiment 1.

Embodiment 4

Used crude drug is Radix Paeoniae Rubra 88g, Radix Linderae 88g, Rhizoma Cyperi 88g, Radix Sophorae Flavescentis 88g, Artemisia anomah S. Moore 88g, Rhizoma Dioscoreae Hypoglaucae 88g, Herba Polygoni Avicularis 88g, Polyporus 130g, Fructus Ligustri Lucidi 109g in the present embodiment; Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi are pulverized, cross 200 mesh sieves, form the micropowder of three kinds of medical materials; With Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae ， Herba Polygoni Avicularis, Polyporus, the mixture of Fructus Ligustri Lucidi Six-element medical material decocts with water, and collecting decoction filters, and filtrate decompression is concentrated into the thick paste that relative density is 1.30 (60 ℃); In thick paste, add Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi fine powder after pulverizing, mixing, cold drying is ground into the micropowder that particle diameter is 10 μ m, and mixing gets active constituents of medicine, is prepared from a kind of Chinese medicine composition for the treatment of gynaecopathia.

Preparation method is with embodiment 1.

Embodiment 5

Used crude drug is Radix Paeoniae Rubra 110g, Radix Linderae 110g, Rhizoma Cyperi 110g, Radix Sophorae Flavescentis 110g, Artemisia anomah S. Moore 110g, Rhizoma Dioscoreae Hypoglaucae 110g, Herba Polygoni Avicularis 110g, Polyporus 100g, Fructus Ligustri Lucidi 90g in the present embodiment; Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi are pulverized, cross 200 mesh sieves, form the micropowder of three kinds of medical materials; With Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae ， Herba Polygoni Avicularis, Polyporus, the mixture of Fructus Ligustri Lucidi Six-element medical material decocts with water, and collecting decoction filters, and filtrate decompression is concentrated into the thick paste that relative density is 1.25 (60 ℃); In thick paste, add Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi fine powder after pulverizing, mixing, cold drying is ground into the micropowder that particle diameter is 30 μ m, and mixing gets active constituents of medicine, is prepared from a kind of Chinese medicine composition for the treatment of gynaecopathia.

Preparation method is with embodiment 1.

Embodiment 6

Used crude drug is Radix Paeoniae Rubra 100g, Radix Linderae 100g, Rhizoma Cyperi 100g, Radix Sophorae Flavescentis 100g, Artemisia anomah S. Moore 100g, Rhizoma Dioscoreae Hypoglaucae 100g, Herba Polygoni Avicularis 100g, Polyporus 85g, Fructus Ligustri Lucidi 68g in the present embodiment.

Its preparation method is:

(1) crude drug of getting above-mentioned weight is cleaned, and is standby;

(3) Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi medicated powder after adding is pulverized in thick paste, mixing carries out cold drying under 60 ℃, be ground into the micropowder that particle diameter is 40 μ m, and mixing promptly gets active constituents of medicine.

(4) add low-substituted hydroxypropyl cellulose in active constituents of medicine, consumption is 3% of an active constituents of medicine weight, granulates, and carries out cold drying under 60 ℃, granulate adds magnesium stearate, and consumption is 0.3% of an active constituents of medicine amount, mixing, tabletting makes tablet.

Embodiment 7

Used process equipment and raw material be substantially with embodiment 6, and only different is with Radix Paeoniae Rubra 87g, Radix Linderae 87g, Rhizoma Cyperi 87g, Radix Sophorae Flavescentis 87g, Artemisia anomah S. Moore 87g, Rhizoma Dioscoreae Hypoglaucae 87g, Herba Polygoni Avicularis 87g, Polyporus 131g, Fructus Ligustri Lucidi 110g is raw material.

Add low-substituted hydroxypropyl cellulose in active constituents of medicine, consumption is 3% of an active constituents of medicine weight, granulates, and carries out cold drying under 60 ℃, and granulate adds magnesium stearate 0.8%, mixing, and tabletting, coating makes coated tablet.

Embodiment 8

Used crude drug is Radix Paeoniae Rubra 88g, Radix Linderae 88g, Rhizoma Cyperi 88g, Radix Sophorae Flavescentis 88g, Artemisia anomah S. Moore 88g, Rhizoma Dioscoreae Hypoglaucae 88g, Herba Polygoni Avicularis 88g, Polyporus 130g, Fructus Ligustri Lucidi 109g in the present embodiment.

Its preparation method is:

(1) crude drug of getting above-mentioned weight is cleaned, and is standby;

(2) Radix Paeoniae Rubra is cut into the 2mm sheet, the Radix Linderae is cut into 0.2mm sheet, Rhizoma Cyperi fragmentation, and Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi are pulverized, and crosses 200 mesh sieves, mixing; The mixture of Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae, Herba Polygoni Avicularis, Polyporus, Fructus Ligustri Lucidi Six-element medical material is decocted with water three times, for the first time amount of water is that 10 times of mixture decocted 2 hours, for the second time amount of water is that 8 times of mixture decocted 2 hours, amount of water is 8 times of mixture and decocted 1 hour for the third time, decoct temperature and be controlled at 80 ℃, collecting decoction filters, and filtrate decompression is concentrated into the thick paste that relative density is 1.25 (60 ℃);

(3) Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi medicated powder after adding is pulverized in thick paste, mixing carries out cold drying under 40 ℃, be ground into the micropowder that particle diameter is 0.5 μ m, and mixing promptly gets active constituents of medicine.

(4) add microcrystalline Cellulose, pregelatinized Starch and hydroxypropyl cellulose in active constituents of medicine, consumption is 2% of an active constituents of medicine weight, granulates, and carries out cold drying at 60 ℃, and with silicon dioxide, magnesium stearate mixing, tabletting makes vaginal tablet.

Embodiment 9

Its preparation method is:

(1) crude drug of getting above-mentioned weight is cleaned, and is standby;

(2) Radix Paeoniae Rubra is cut into the 3mm sheet, the Radix Linderae is cut into 2mm sheet, Rhizoma Cyperi fragmentation, and Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi are pulverized, and crosses 300 mesh sieves, mixing; The mixture of Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae, Herba Polygoni Avicularis, Polyporus, Fructus Ligustri Lucidi Six-element medical material is decocted with water three times, the mixture of Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae, Herba Polygoni Avicularis, Polyporus, Fructus Ligustri Lucidi Six-element medical material is decocted with water three times, for the first time amount of water is that 12 times of mixture decocted 3 hours, for the second time amount of water is that 8 times of mixture decocted 2 hours, amount of water is 6 times of mixture and decocted 1 hour for the third time, decoct temperature and be controlled at 90 ℃, collecting decoction, filter, filtrate decompression is concentrated into the thick paste that relative density is 1.30 (60 ℃);

(4) with 1 part of 5 parts of dissolvings of 95% ethanol Polyethylene Glycol, add 1 part of sodium bicarbonate again in lysate, it is standby to make mixed liquor; The mixed liquor that makes sprayed in the spray-drying pelleting machine of splendid attire active constituents of medicine and starch, carry out spray drying, cross 10 mesh sieves, granulate; Granule behind the granulate and citric acid are crossed granule, the fumaric acid fine powder mix homogeneously of 10 mesh sieves, and tabletting makes effervescent tablet.Inlet temperature when carrying out spray drying is 75 ℃, and temperature of charge is 70 ℃, and atomisation pressure is 0.1Mpa, and the transfusion frequency is 10r/min, and amount of starch is 2.5% of an active constituents of medicine in the spray-drying pelleting machine.

Embodiment 10

Used process equipment and raw material be substantially with embodiment 9, and only different is with Radix Paeoniae Rubra 68g, Radix Linderae 68g, Rhizoma Cyperi 68g, Radix Sophorae Flavescentis 68g, Artemisia anomah S. Moore 68g, Rhizoma Dioscoreae Hypoglaucae 68g, Herba Polygoni Avicularis 68g, Polyporus 170g, Fructus Ligustri Lucidi 136g is raw material.

With 1.5 parts of 6 parts of dissolvings of 95% ethanol Polyethylene Glycol, in lysate, add 1.5 parts of sodium bicarbonate again, it is standby to make mixed liquor; The mixed liquor that makes sprayed in the spray-drying pelleting machine of splendid attire active constituents of medicine and starch, carry out spray drying, cross 20 mesh sieves, granulate; Granule behind the granulate and citric acid are crossed granule, the fumaric acid fine powder mix homogeneously of 20 mesh sieves, and tabletting makes effervescent tablet.Inlet temperature when carrying out spray drying is controlled at 85 ℃, and temperature of charge is controlled at 80 ℃, and atomisation pressure is 0.2Mpa, and the transfusion frequency is 20r/min, and amount of starch is 2.5% of an active constituents of medicine in the spray-drying pelleting machine.

Embodiment 11

Used process equipment and raw material be substantially with embodiment 9, and only different is with 110g, Radix Linderae 110g, Rhizoma Cyperi 110g, Radix Sophorae Flavescentis 110g, Artemisia anomah S. Moore 110g, Rhizoma Dioscoreae Hypoglaucae 110g, Herba Polygoni Avicularis 110g, Polyporus 100g, Fructus Ligustri Lucidi 90g is raw material.

With 2 parts of 4 parts of dissolvings of 95% ethanol Polyethylene Glycol, in lysate, add 2 parts of sodium bicarbonate again, it is standby to make mixed liquor; The mixed liquor that makes sprayed in the spray-drying pelleting machine of splendid attire active constituents of medicine and starch, carry out spray drying, cross 30 mesh sieves, granulate; Granule behind the granulate and citric acid are crossed granule, the fumaric acid fine powder mix homogeneously of 30 mesh sieves, and tabletting makes effervescent tablet.Inlet temperature when carrying out spray drying is controlled at 95 ℃, and temperature of charge is controlled at 90 ℃, and atomisation pressure is 0.3Mpa, and the transfusion frequency is 40r/min, and amount of starch is 3.5% of an active constituents of medicine in the spray-drying pelleting machine.

Embodiment 12

Its preparation method is:

(1) crude drug of getting above-mentioned weight is cleaned, and is standby;

(2) Radix Paeoniae Rubra is cut into the 2mm sheet, the Radix Linderae is cut into 0.2mm sheet, Rhizoma Cyperi fragmentation, and Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi are pulverized, and crosses 200 mesh sieves, mixing; The mixture of Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae, Herba Polygoni Avicularis, Polyporus, Fructus Ligustri Lucidi Six-element medical material is decocted with water three times, for the first time amount of water is that 10 times of mixture decocted 2 hours, for the second time amount of water is that 8 times of mixture decocted 2 hours, amount of water is 8 times of mixture and decocted 1 hour for the third time, decoct temperature and be controlled at 100 ℃, collecting decoction filters, and filtrate decompression is concentrated into the thick paste that relative density is 1.30 (60 ℃);

(3) Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi medicated powder after adding is pulverized in thick paste, mixing carries out cold drying under 60 ℃, be ground into the micropowder that particle diameter is 5 μ m, and mixing promptly gets active constituents of medicine.

(4) in active constituents of medicine, add 1 part of 1 part in dextrin and sucrose, mixing, the ethanol that adds 60% percentage by weight is done binding agent in right amount, granulates, and carries out cold drying under 40 ℃ temperature, and granulate is crossed 10 mesh sieves, and packing makes and contains sugared granule.

Embodiment 13

Used process equipment and raw material be substantially with embodiment 12, and only different is with Radix Paeoniae Rubra 93g, Radix Linderae 93g, Rhizoma Cyperi 93g, Radix Sophorae Flavescentis 93g, Artemisia anomah S. Moore 93g, Rhizoma Dioscoreae Hypoglaucae 93g, Herba Polygoni Avicularis 93g, Polyporus 120g, Fructus Ligustri Lucidi 80g is raw material.

In active constituents of medicine, add 3 parts of 2 parts in dextrin and sucrose, mixing, the ethanol that adds 75% percentage by weight is done binding agent in right amount, granulates, and carries out cold drying under 60 ℃ temperature, and granulate is crossed 30 mesh sieves, and packing makes and contains sugared granule.

Embodiment 14

Its preparation method is:

(1) crude drug of getting above-mentioned weight is cleaned, and is standby;

(2) Radix Paeoniae Rubra is cut into the 2mm sheet, the Radix Linderae is cut into 0.2mm sheet, Rhizoma Cyperi fragmentation, and Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi are pulverized, and crosses 150 mesh sieves, mixing; The mixture of Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae, Herba Polygoni Avicularis, Polyporus, Fructus Ligustri Lucidi Six-element medical material is decocted with water three times, for the first time amount of water is that 10 times of mixture decocted 2 hours, for the second time amount of water is that 8 times of mixture decocted 2 hours, amount of water is 8 times of mixture and decocted 1 hour for the third time, decoct temperature and be controlled at 100 ℃, collecting decoction filters, and filtrate decompression is concentrated into the thick paste that relative density is 1.30 (60 ℃);

(3) Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi medicated powder after adding is pulverized in thick paste, mixing carries out cold drying under 60 ℃, be ground into the micropowder that particle diameter is 10 μ m, and mixing promptly gets active constituents of medicine.

(4) in active constituents of medicine, add 1 part in dextrin, mixing, the ethanol that adds 60% percentage by weight is done binding agent in right amount, granulates, and carries out cold drying under 40 ℃ temperature, and granulate is crossed 10 mesh sieves, and packing makes sugar free granule.

Embodiment 15

Used process equipment and raw material be substantially with embodiment 14, and only different is with Radix Paeoniae Rubra 100g, Radix Linderae 100g, Rhizoma Cyperi 100g, Radix Sophorae Flavescentis 100g, Artemisia anomah S. Moore 100g, Rhizoma Dioscoreae Hypoglaucae 100g, Herba Polygoni Avicularis 100g, Polyporus 85g, Fructus Ligustri Lucidi 68g is raw material;

In active constituents of medicine, add 2 parts in dextrin, mixing, the ethanol that adds 75% percentage by weight is done binding agent in right amount, granulates, and carries out cold drying under 60 ℃ temperature, and granulate is crossed 30 mesh sieves, and packing makes sugar free granule.

Embodiment 16

Its preparation method is:

(1) crude drug of getting above-mentioned weight is cleaned, and is standby;

(2) Radix Paeoniae Rubra is cut into the 2.5mm sheet, the Radix Linderae is cut into 1.5mm sheet, Rhizoma Cyperi fragmentation, and Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi are pulverized, and crosses 250 mesh sieves, mixing; The mixture of Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae, Herba Polygoni Avicularis, Polyporus, Fructus Ligustri Lucidi Six-element medical material is decocted with water three times, for the first time amount of water is that 10 times of mixture decocted 2 hours, for the second time amount of water is that 8 times of mixture decocted 2 hours, amount of water is 8 times of mixture and decocted 1 hour for the third time, decoct temperature and be controlled at 100 ℃, collecting decoction filters, and filtrate decompression is concentrated into the thick paste that relative density is 1.30 (60 ℃);

(3) Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi medicated powder after adding is pulverized in thick paste, mixing carries out cold drying under 60 ℃, be ground into the micropowder that particle diameter is 30 μ m, and mixing promptly gets active constituents of medicine.

(4) in the watered pill machine that active constituents of medicine is housed, add entry, use water pill, dry under 50 ℃ temperature, promptly get the watered pill.

Embodiment 17

Used crude drug is Radix Paeoniae Rubra 110g, Radix Linderae 110g, Rhizoma Cyperi 110g, Radix Sophorae Flavescentis 110g, Artemisia anomah S. Moore 110g, Rhizoma Dioscoreae Hypoglaucae 110g, Herba Polygoni Avicularis 110g, Polyporus 100g, Fructus Ligustri Lucidi 90g in the present embodiment.

Its preparation method is:

(1) crude drug of getting above-mentioned weight is cleaned, and is standby;

(2) Radix Paeoniae Rubra is cut into the 2.5mm sheet, the Radix Linderae is cut into 1mm sheet, Rhizoma Cyperi fragmentation, and Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi are pulverized, and crosses 180 mesh sieves, mixing; The mixture of Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae, Herba Polygoni Avicularis, Polyporus, Fructus Ligustri Lucidi Six-element medical material is decocted with water three times, for the first time amount of water is that 12 times of mixture decocted 2 hours, for the second time amount of water is that 8 times of mixture decocted 2 hours, amount of water is 6 times of mixture and decocted 1 hour for the third time, decoct temperature and be controlled at 90 ℃, collecting decoction filters, and filtrate decompression is concentrated into the thick paste that relative density is 1.25 (60 ℃);

(3) Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi medicated powder after adding is pulverized in thick paste, mixing carries out cold drying under 40 ℃, be ground into the micropowder that particle diameter is 20 μ m, and mixing promptly gets active constituents of medicine.

(4) add refined honey in active constituents of medicine, consumption is 35% of an active constituents of medicine amount, and reuse water is used water pill as extracting solvent, and is dry under 40 ℃ temperature, makes water-honeyed pill.

Embodiment 18

Used process equipment and raw material be substantially with embodiment 18, and only different is with Radix Paeoniae Rubra 68g, Radix Linderae 68g, Rhizoma Cyperi 68g, Radix Sophorae Flavescentis 68g, Artemisia anomah S. Moore 68g, Rhizoma Dioscoreae Hypoglaucae 68g, Herba Polygoni Avicularis 68g, Polyporus 170g, Fructus Ligustri Lucidi 136g is raw material.

Add refined honey in active constituents of medicine, consumption is 50% of an active constituents of medicine amount, and reuse water is used water pill as extracting solvent, and is dry under 60 ℃ temperature, makes water-honeyed pill.

Embodiment 19

Used crude drug is Radix Paeoniae Rubra 93g, Radix Linderae 93g, Rhizoma Cyperi 93g, Radix Sophorae Flavescentis 93g, Artemisia anomah S. Moore 93g, Rhizoma Dioscoreae Hypoglaucae 93g, Herba Polygoni Avicularis 93g, Polyporus 120g, Fructus Ligustri Lucidi 80g in the present embodiment.

Its preparation method is:

(1) crude drug of getting above-mentioned weight is cleaned, and is standby;

(2) Radix Paeoniae Rubra is cut into the 2mm sheet, the Radix Linderae is cut into 2mm sheet, Rhizoma Cyperi fragmentation, and Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi are pulverized, and crosses 200 mesh sieves, mixing; The mixture of Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae, Herba Polygoni Avicularis, Polyporus, Fructus Ligustri Lucidi Six-element medical material is decocted with water three times, for the first time amount of water is that 12 times of mixture decocted 2 hours, for the second time amount of water is that 8 times of mixture decocted 2 hours, amount of water is 6 times of mixture and decocted 1 hour for the third time, decoct temperature and be controlled at 90 ℃, collecting decoction filters, and filtrate decompression is concentrated into the thick paste that relative density is 1.25 (60 ℃);

(4) add refined honey in active constituents of medicine, consumption is 100% of an active constituents of medicine amount, makes big honeyed pills.

Embodiment 20

Used process equipment and raw material be substantially with embodiment 20, and only different is with Radix Paeoniae Rubra 110g, Radix Linderae 110g, Rhizoma Cyperi 110g, Radix Sophorae Flavescentis 110g, Artemisia anomah S. Moore 110g, Rhizoma Dioscoreae Hypoglaucae 110g, Herba Polygoni Avicularis 110g, Polyporus 100g, Fructus Ligustri Lucidi 90g is raw material;

Add refined honey in active constituents of medicine, consumption is 120% of an active constituents of medicine amount, makes big honeyed pills.

Embodiment 21

Its preparation method is:

(1) crude drug of getting above-mentioned weight is cleaned, and is standby;

(4) add supplementary product starch in active constituents of medicine, consumption is 1.0% of an active constituents of medicine amount, granulates, and dresses up capsule, makes capsule.

Embodiment 22

Used process equipment and raw material be substantially with embodiment 21, and only different is with Radix Paeoniae Rubra 93g, Radix Linderae 93g, Rhizoma Cyperi 93g, Radix Sophorae Flavescentis 93g, Artemisia anomah S. Moore 93g, Rhizoma Dioscoreae Hypoglaucae 93g, Herba Polygoni Avicularis 93g, Polyporus 120g, Fructus Ligustri Lucidi 80g is raw material;

Add supplementary product starch in active constituents of medicine, consumption is 3.0% of an active constituents of medicine amount, granulates, and dresses up capsule, makes capsule.

Claims

1, the application of a kind of Chinese medicine composition in preparation treatment adnexitis, ovarian cyst, vaginitis and cervicitis medicine is characterized in that its method comprises the steps: in the preparation process of this Chinese medicine composition

(2) Radix Paeoniae Rubra is cut into the 2-3mm sheet, the Radix Linderae is cut into 0.2-2mm sheet, Rhizoma Cyperi fragmentation, and Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi are pulverized, and crosses the 150-300 mesh sieve, mixing; The mixture of Radix Sophorae Flavescentis, Artemisia anomah S. Moore, Rhizoma Dioscoreae Hypoglaucae, Herba Polygoni Avicularis, Polyporus, Fructus Ligustri Lucidi Six-element medical material is decocted with water, and collecting decoction filters, and the control temperature is concentrated into the thick paste that relative density is 1.25-1.30 at 60 ℃, filtrate decompression; The condition that decocting boils is, decocts with water 3 times, and amount of water is 10 times of amounts, the decoction 2 hours of Six-element medical material mixture for the first time; For the second time amount of water is 8 times of amounts, the decoction 2 hours of Six-element medical material mixture; For the third time amount of water be Six-element medical material mixture 8 times of amounts, decocted 1 hour, decocting temperature is 100 ℃;

(3) Radix Paeoniae Rubra, the Radix Linderae, Rhizoma Cyperi medicated powder after adding is pulverized in thick paste, mixing carries out cold drying under 40-60 ℃, be ground into the micropowder that particle diameter is 0.5-40 μ m, and mixing promptly gets active constituents of medicine.

2, the application of Chinese medicine composition as claimed in claim 1 in preparation treatment adnexitis, ovarian cyst, vaginitis and cervicitis medicine is characterized in that: add adjuvant, mixing in active constituents of medicine, granulate, tabletting is prepared into tablet or carries out coating, makes coated tablet.

3, the application of Chinese medicine composition as claimed in claim 1 in preparation treatment adnexitis, ovarian cyst, vaginitis and cervicitis medicine is characterized in that: add adjuvant in active constituents of medicine, mixing is granulated, drying, and packing is prepared into granule.

4, the application of Chinese medicine composition as claimed in claim 1 in preparation treatment adnexitis, ovarian cyst, vaginitis and cervicitis medicine, it is characterized in that: add adjuvant in active constituents of medicine, mixing is prepared into pill.

5, the application of Chinese medicine composition as claimed in claim 1 in preparation treatment adnexitis, ovarian cyst, vaginitis and cervicitis medicine is characterized in that: in active constituents of medicine, add adjuvant, and mixing, drying, encapsulated, be prepared into capsule.