CN110101791A - A kind of pharyngitis mouth-sucking tablet and preparation method thereof - Google Patents
A kind of pharyngitis mouth-sucking tablet and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to technical field of Chinese medicine, in particular to a kind of pharyngitis mouth-sucking tablet and preparation method thereof, the pharyngitis mouth-sucking tablet, it is made of the raw material of following quality proportionings: honeysuckle 100-130g, chrysanthemum 65-80g, wild chrysanthemum 65-82g, blackberry lily 90-110g, radix scutellariae 90-110g, caulis akebiae 90-110g, Radix Ophiopogonis 950-1050g, asparagus fern 90-110g, campanulaceae 70-90g, caulis lonicerae 100-130g, Radix Glycyrrhizae 70-90g, menthol 0.110-0.140g.Not only preparation process is simple for formula of the present invention, low in cost, and better stability of preparation, has more good therapeutic effect, overcomes existing direct water and proposes the impaired defect of chrysanthemum present in technology, wild chrysanthemum ingredient.Pharyngitis mouth-sucking tablet prepared by the present invention can more effectively treat acute/chronic pharyngitis, adequately apply and directly act on the lesion of pharyngitis and played local treatment as mark, the clearing heat and detoxicating conditioning of whole body is this traditional medicine therapeutic thoughts.
Description
Technical field
The present invention relates to technical field of Chinese medicine, in particular to a kind of pharyngitis mouth-sucking tablet and preparation method thereof.
Background technique
Pharyngitis is caused by being inflamed due to pharyngeal mucosa tissue, and treating pharyngitis medication will with caution, and voluntarily medication is likely to
To aggravating one's illness, especially some hormonal medicaments, it is possible at that time effectively, but later just without effect, it is easy to cause disease
Feelings recurrent exerbation.At present market treatment pharyngitis drug in, side effect caused by Conventional antibiotic, with the side effect of Western medicine compared with
Greatly, it is also easy to produce adverse reaction, and the therapeutic effect of Chinese medicine is bad, curative effect is unstable, it is difficult to eradicate.
Summary of the invention
The purpose of the present invention is to provide a kind of pharyngitis mouth-sucking tablet and preparation method thereof, solve to treat pharyngitis in the prior art
The bad problem of herbal medicine efficacy.
Realization process of the invention is as follows:
A kind of pharyngitis mouth-sucking tablet is made of the raw material of following quality proportionings: honeysuckle 100-130g, chrysanthemum 65-80g, mother chrysanthemum
Spend 65-82g, blackberry lily 90-110g, radix scutellariae 90-110g, caulis akebiae 90-110g, Radix Ophiopogonis 950-1050g, asparagus fern 90-110g, campanulaceae
70-90g, caulis lonicerae 100-130g, Radix Glycyrrhizae 70-90g, menthol 0.110-0.140g.
Above-mentioned pharyngitis mouth-sucking tablet, the quality proportioning of each raw material are as follows: honeysuckle 120g, chrysanthemum 72g, wild chrysanthemum 72g, blackberry lily
100g, radix scutellariae 100g, caulis akebiae 100g, Radix Ophiopogonis 1000g, asparagus fern 100g, campanulaceae 80g, caulis lonicerae 120g, Radix Glycyrrhizae 80g, menthol
0.132g。
The preparation method of above-mentioned pharyngitis mouth-sucking tablet, includes the following steps:
(1) each raw material, honeysuckle 100-130g, chrysanthemum 65-80g, wild chrysanthemum 65-82g, blackberry lily are weighed by quality proportioning
90-110g, radix scutellariae 90-110g, caulis akebiae 90-110g, Radix Ophiopogonis 950-1050g, asparagus fern 90-110g, campanulaceae 70-90g, caulis lonicerae
100-130g, Radix Glycyrrhizae 70-90g, menthol 0.110-0.140g, for use；
(2) the weighed 65-80g chrysanthemum of step (1) and 65-82g wild chrysanthemum are passed through into extraction by steam distillation volatile oil,
It is spare, while the chrysanthemum dregs of a decoction and the wild chrysanthemum dregs of a decoction are obtained, it is spare；
(3) the chrysanthemum dregs of a decoction and the wild chrysanthemum dregs of a decoction and honeysuckle 100-130g, blackberry lily 90-110g, Huang obtained step (2)
It is a kind of reed mentioned in ancient books 90-110g, caulis akebiae 90-110g, Radix Ophiopogonis 950-1050g, asparagus fern 90-110g, campanulaceae 70-90g, caulis lonicerae 100-130g, sweet
After careless 70-90g mixing, adds water to cook twice, collect decoction liquor, filtrate is obtained after filtering, filtrate is concentrated into relative density and is
1.29-1.31 thick paste, it is spare；
(4) thick paste that step (3) obtains is mixed with powdered glucose, particle is made after mixing, dried, the thick paste
Mixing quality ratio with powdered glucose is 4:3；
(5) 0.110-0.140g menthol is dissolved in ethyl alcohol, is adsorbed with aluminium hydroxide, be sieved, obtain the second of menthol
Alcoholic solution；
(6) ethanol solution of the particle that step (4) obtains and the menthol that step (5) obtains is uniformly mixed, sprays into step
Suddenly the volatile oil that (2) are extracted seals 1-1.5 hours, is pressed into 350-450 piece pharyngitis mouth-sucking tablet.
Further, the method that step (2) chrysanthemum, wild chrysanthemum extract volatile oil is to use steam distillation；It is described
The concrete operation method of steam distillation is to soak above-mentioned chrysanthemum, wild chrysanthemum, puts into multi-function extractor, closes upper cover
And exhaust-valve, it opens and receives oil valve, slowly open straight air valve, pressure is no more than 0.02mpa, and interlayer air valve pressure is no more than
0.03mpa opens cooling water inlet valve and oil water separator liquid feed valve, closes oil water separator blowdown valve；True air valve is closed, is made
It is collected 3 hours to be there is volatile oil appearance in oil water separator with indirect steam, obtains the Mixed chaotic sequences of chrysanthemum and wild chrysanthemum,
It is spare.
Further, step (3) is described decocts twice, wherein and the mass ratio of raw material and water is 1:5 in decocting for the first time,
First time decocting time is 1.5-2.5 hours, filters after decoction, obtains the first time dregs of a decoction and first time decoction liquor；Second
The mass ratio of the first time dregs of a decoction and water is 1:3 in secondary decoction, and second of decocting time is 1-2 hours, is filtered after decoction,
Obtain second of dregs of a decoction and second of decoction liquor；Merge first time decoction liquor and second of decoction liquor obtains described in step (3)
Decoction liquor.
Further, the granularity of step (4) described particle is 40-60 mesh, and the temperature of the drying is controlled at 40-60 DEG C, institute
Particle drying is stated to 3% or less moisture weight.
Further, step (5) sieving is the sieve of 40-60 mesh.
The positive effect of the present invention:
(1) present invention effectively remains chrysanthemum, open country using extraction by steam distillation chrysanthemum, the volatile oil of wild chrysanthemum
The small molecule volatile oil of chrysanthemum avoids direct water from extracting the loss for causing effective component；
(2) volatile oil in the present invention is largely effective to the treatment sore of the lesion of pharyngitis patient, removing toxic substances, the effect of detumescence；
(3) this project preparation process is simple, low in cost, and preparation stability is good, has good substitution modern medicine anti-
The effect of raw element；
(4) not only preparation process is simple for formula of the present invention, low in cost, and better stability of preparation, has more
Good therapeutic effect overcomes existing direct water and proposes the impaired defect of chrysanthemum present in technology, wild chrysanthemum ingredient.The present invention
Prepared pharyngitis mouth-sucking tablet can more effectively treat acute/chronic pharyngitis, adequately apply the lesion for directly acting on pharyngitis
To local treatment has been arrived as mark, the clearing heat and detoxicating conditioning of whole body is traditional medicine therapeutic thoughts originally.
Detailed description of the invention
Fig. 1 is the preparation technology flow chart of pharyngitis mouth-sucking tablet of the present invention.
Specific embodiment
Below with reference to embodiment, the present invention will be further described.
In order to solve the problems, such as that the herbal medicine efficacy for treating pharyngitis in the prior art is bad, the present invention provides a kind of pharyngitis mouth-sucking tablet
And preparation method thereof.
The medical value introduction of raw material involved in the present invention:
The medical value of honeysuckle: honeysuckle is just extensive and famous with its medical value since ancient times.Its effect is main
Be it is clearing heat and detoxicating, cure mainly warm disease heating, toxic-heat and blood stasis, ulcer serious case of furuncle etc..Modern study proves that honeysuckle contains chlorogenic acid, wood
The pharmacological components such as the plain glycosides of rhinoceros grass, to the various pathogens such as hemolytic streptococcus, Staphylococcus aureus and the infection of the upper respiratory tract
Causative virus etc. has stronger restraint, in addition can also strengthen immunity, Robust speaker feature, protect liver, antitumor, anti-inflammatory, antipyretic, hemostasis
(blood coagulation), inhibition intestinal absorption cholesterol etc., clinical application is very extensive, can be with other medicines compatibility for treating respiratory tract
More than 40 illness such as infection, bacillary dysentery, acute urinary, hypertension.Honeysuckle is cold in nature, sweet in flavor, enters lung, the heart, stomach meridian, tool
There is the effect of clearing heat and detoxicating, anti-inflammatory, qi-restoratives treats wind, cures mainly disease under turgor, warm disease heating, the diseases such as heat toxin large carbuncle and tumour.Its is right
In dizziness, thirst, sweating and boring, enteritis, bacillary dysentery, morbilli, pneumonia, encephalitis, epidemic meningitis, acute mastitis, septicemia,
The illnesss such as ecphyaditis, skin infection, ulcer boils, erysipelas, parotitis, suppurative tonsillitis have certain curative effect.
The medical value of chrysanthemum: [nature and flavor] sweetness and bitterness, it is cool.1. Shennong's Herbal: " bitter is put down." 2. " Bie Lu ": " is sweet, nontoxic."③
" Tian Bao folk prescription figure ": " feverfew: acrid flavour is put down, nontoxic." 4. " occupying diet spectrum with breath ": " is sweet, cool." [channel tropism] enters lung, Liver Channel." thunder
Public affairs process pharmacological property solution ": " enter lung, spleen；Liver, kidney four pass through." [major function] dispelling wind, heat-clearing, improving eyesight, removing toxic substances.Control headache, dizziness,
Hot eyes, ambition dysphoria with smothery sensation, furunculosis, pyogenic infections.
The medical value of wild chrysanthemum: wild chrysanthemum cold nature has dispelling wind and heat from the body, subdhing swelling and detoxicating.Furunculosis carbuncle swells, throat can be treated
The diseases such as swelling and pain, wind-fire red eye, headache and dizziness.
The medical value of blackberry lily: rhizomes is medicinal, bitter, cold in nature, micro- poison.Stop up caused by Sheng for experiencing wind-heat or phlegm heat
The diseases such as abscess of throat.For accumulation and obstruction of sputum, the diseases such as cough and asthma.Abscess of throat, sore throat is obstructed, constipation and anuresis, and all medicines are not imitated,
Abdomen ponding, skin black, acute mastitis from the beginning of.
The medical value of radix scutellariae: (1) heat-clearing and damp-drying drug: radix scutellariae is for damp-warm syndrome fever, uncomfortable in chest, feeling thirst but no desire to drink and damp and hot
The diseases such as dysentery, jaundice, therefore have effects that heat-clearing and damp-drying drug.It generates heat damp-warm syndrome, with the fit applications such as talcum, roud cardamon seed, Poria cocos；
To damp-heat dysentery, abdominal pain, it is equal with Radix Paeoniae Alba, pueraria lobata, Radix Glycyrrhizae and uses；For jaundice caused by damp-heat accumulation, can with oriental wormwood, cape jasmine,
Lophatherum gracile is equally used.(2) cool blood miscarriage prevention: the threatened abortion of scutellaria for treating pregnant woman, cool blood miscarriage prevention.Often cooperate with Rhizoma Atractylodis Macrocephalae, caulis bambusae in taenian etc.
Using playing the role of preventing miscarriage.(3) cure mainly warm heat disease: radix scutellariae cures mainly warm heat disease, and warm heat disease particularity shows as anxious, change of falling ill
Change is fast, deterioration of a case is more, and in addition to must have fever, most calorific potential is higher.Radix scutellariae is taken, the state of an illness can be alleviated.
The medical value of caulis akebiae: clearing away the heart-fire, diuresis are newborn under promoting menstruation.For aphthae, red, the oedema of vexed urine, heat gonorrhea
Puckery pain, leukorrhea, menostasis cream is few, damp and hot numbness pain.
The medical value of Radix Ophiopogonis: Radix Ophiopogonis is classified as the top grade of Yin nourishing and lung moistening by Shennong's Herbal, and saying it, " long term usage is made light of one's life by commiting suicide, no
It is old not hungry "." herbal lease making " title Radix Ophiopogonis " sweet, slight bitter, it is slightly cold.Moistening lung and clearing away the heart-fire purges heat and promotes the production of body fluid, resolving sputum preventing or arresting vomiting, controls row water of coughing ".
" Records of Tradition Chinese and Western Medicine in Combination " says it: " can enter stomach with nourishing the stomach liquid, stimulating appetite can more enter spleen to help spleen to dissipate and be skillful in lung, and Dingchuan is peaceful
It coughs." Chinese medicine thinks, Radix Ophiopogonis is sweet in flavor, slight bitter, cold nature returns stomach, lung, the heart channel of Hang-Shaoyin, there is Yin nourishing and lung moistening, reinforcing stomach reg fluid, relieving restlessness and restlessness
Effect, for diseases such as dryness of the lung dry cough, cough for deficiency of Yin consumptive disease, larynx numbness pharyngalgia, injury thirst, Heat Diabetes, vexed insomnia, dry constipation of intestines.
Modern pharmacological research also indicates that, Radix Ophiopogonis mainly contain dwarf lilyturf glycosides, steroid saponin, alkaloid, sitosterol, powdered glucose, amino acid,
Vitamin etc., have the function of it is antifatigue, remove free radical, improve cellular immune function and hypoglycemic.In addition, there is town in Radix Ophiopogonis
Quiet, hypnosis, resist myocardial ischemia, anti-arrhythmia, it is antitumor the effects of, especially there is many-sided function to promoting senior health and fitness
Effect.In addition, Radix Ophiopogonis is in sugared friendly prescription there are also the effect for promoting islet cell function to restore, increasing hepatic glycogen, reducing blood glucose
Regular supplies.Radix Ophiopogonis can be on behalf of the tea.Appropriate Radix Ophiopogonis is taken, boiled water impregnates, and several times, the symptom of thirsty can be effectively relieved in more clothes daily.
Part of diabetes mellitus patient's deficiency of both qi and yin, therefore when drinking Radix Ophiopogonis water, it can allow some Radix Codonopsis, can more play the role of tonifying Qi.Wheat
Winter should not take for a long time, especially in the case where no physician guidance, otherwise may give birth to phlegm life it is wet, run counter to desire.In addition, Radix Ophiopogonis
Not everybody is suitble to, and the people of deficiency-cold in spleen and stomach, flu had better not at will eat Radix Ophiopogonis, otherwise can aggravate the state of an illness.
The medical value of asparagus fern: asparagus fern is the root of lucid asparagus, asparagus fern so and Tianmen can be referred to as, asparagus fern
Pharmacological property is cold, sweet and slightly bitter taste, below with regard to let us come the effect of looking at asparagus fern with effect.(1) nourishing Yin and promoting production of body fluid: treatment fever due to yin deficiency,
Dryness of the lung dry cough, cough due to consumptive disease, injury thirst have good effect.(2) moistening lung and clearing away the heart-fire: treatment vexed insomnia, abscess of throat, interior heat
It quenches one's thirst, there is good curative effect.(3) relax bowel and defecation: asparagus fern has good help for the constipation caused by our body contents,
Us can be helped to play the role of ease constipation, effect is better for the people of the deficiency of Yin.(4) antibacterial anti-inflammatory: asparagus fern is also
Antibacterial and anti-inflammation functions, to tracheitis, pneumonia, pulmonary tuberculosis, various coughing with a lot of sputum caused by pulmonary emphysema, asthma has good treatment
Effect.Staphylococcus aureus, Diplococcus pneumopniae, deep hemorrhagic streptococcus, corynebacterium diphtheriae, Pseudomonas aeruginosa, bacillus anthracis have not
With the bacteriostasis of degree.(5) remove dry fall fire: asparagus fern also has fire excess from yin deficiency caused osteopyrexia and fever, night sweat, insomnia and dreamful sleep
Certain opsonic action.
The medical value of campanulaceae: promoting the dispersing function of the lung, relieving sore-throat, eliminating the phlegm, apocenosis.For coughing with a lot of sputum, chest distress, pharyngalgia, hoarse voice, lung
Carbuncle pyemesis, sore purulence is not at bursting.
The medical value of caulis lonicerae: [nature and flavor] are sweet, tremble with fear.1. " Bie Lu ": sweet, warm, it is nontoxic." 2. haigoushen ": acrid flavour.③
Supplement to the Herbal: Slight Cold." 4. book on Chinese herbal medicine is new again ": sweet-bitter flavor, cold nature.[channel tropism] attaches to the lung and stomach meridians." 1. key medicine divides agent ": entering lung
Through." 2. book on Chinese herbal medicine is new again ": entering the heart, lung two passes through.[major function] is clearing heat and detoxicating, dispelling wind dredging collateral.For warm disease heating, heat toxin blood
Dysentery, carbuncle swells sore, beriberoid pyretic arthralgia, redness and swelling of joints heat pain." Bie Lu ": " main fever and chills body is swollen." Tao Hongjing: " liquor is to make wine, qi-restoratives
Treat wind." " haigoushen ": " main distention and fullness in the abdomen, can stop Bleach under gas." supplement to the Herbal: " main toxic-heat and blood stasis water dysentery." " Lv Cliff rock sheet
Grass ": " control arthralgia and myalgia." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " wide lower gas, dissolving phlegm, wind-dispelling heat, clearing throat heat pain." " detailed outline ": " controls all
Rheumatism gas and all swelling and pain, ulcer scabies moss, red bayberry malignant sore, heat dissipation removing toxic substances." " book on Chinese herbal medicine new again ": " controls hyperactivity of fire of having a guilty conscience, during tonifying Qi is wide, cough
It coughs, carbuncle impotence." " Nanjing traditional herbal medicine ": " cauline leaf and while spending to inflammatory eye, are effective in cure." " the civil recipe collection in Guizhou ": " leaf: outer
It applies and controls knife wound." Guangzhou army " common Chinese herbal medicine handbook ": " controls damp and hot skelagia."
The medical value of Radix Glycyrrhizae: (1) heart qi deficiency, palpitation and severe palpitation, knotted pulse and deficiency of spleen-QI and stomach-QI, fatigue and weakness etc. are used for.
The former, often with ramulus cinnamomi compatibility, such as Ramuli Cinnamomi and Glycyrrhizae Decoction, zhigancao decoction.The latter is often equal with Radix Codonopsis, Rhizoma Atractylodis Macrocephalae and uses, as Sijunzi Tang,
Ball etc. in reason.(2) for ulcer sores, abscess of throat etc..It can be applied alone, for oral administration or external application or compatibility application.Ulcer sores, often
It is equal with honeysuckle, Fructus Forsythiae and uses, plays clearing heat and detoxicating function, such as Xian fang Huoming Yin altogether.Abscess of throat, often with campanulaceae with use, such as tangerine
Obstruct soup.If pesticide, food poisoning, often matches mung bean or be decocted in water for oral dose with radix saposhnikoviae.(3) it is used for asthma and cough.Can be applied alone, also can compatibility its
His medicinal application.Such as control the erchen tang of damp-phlegm syndrome；Control the Linggan Wuwei Jiangxin Tang of cold productive cough asthma；Control the mulberry apricot of dry stool phlegm cough
Soup；Control heat toxin and cause pulmonary abscess cough saliva smell as of rotten fish phlegm Radix Platycodonis decoction；Control the Gancao Ganjiang soup etc. of cough saliva foam.Another cough due to wind-heat evil, wind
Cold-syndrome cough is coughed, also Chang Peiwu is applied phlegm heat cough.(4) for having a stomachache, abdominal pain and gastrocnemius contraction urgency pain etc., often with Chinese herbaceous peony with using,
The curative effect for controlling contraction urgency pain, such as peony and licorice decoction can be significantly increased.(5) for reconciling the strong of some drugs.As gas is held in seasoning
Soup this product mitigates rheum officinale, the discharge function of saltcake and its to the stimulation of gastrointestinal tract.In addition, also commonly using this product in many prescriptions
Coordinating the drug actions of a prescription.(6) Radix Glycyrrhizae has similar adrenocortical hormones fuction.There is inhibition to make gastroxia caused by histamine
With；And there is antiacid and alleviation gastrointestinal smooth muscle spasm effect.(7) licoflavone, extract of licorice root and enoxolone have significantly
Antitussive effect；Phlegm-dispelling functions are also more significant, and action intensity is glycyrrhizic acid > licoflavone > extract of licorice root.(8) there are also anti-for Radix Glycyrrhizae
Inflammation, anti-allergic effects can protect the throat and tunica mucosa tracheae of inflammation.Extract of licorice root has similar grape to certain poisonous substances with glycyrrhizic acid
The detoxication of Icing Sugar aldehydic acid.(9) Radix Glycyrrhizae was commonly used to treat with climacteric and the symptom that comes is because contain glycyrrhizin in Radix Glycyrrhizae,
It is a kind of compound of similar hormone, it helps to balance the intracorporal hormone-content of women.(10) hypo acid contained by Radix Glycyrrhizae can hinder
The effect of disconnected Induced by Carcinogen tumour growth.
The medical value of menthol: being used as excitants in medicine, act on skin or mucous membrane, there is refrigerant itching-relieving action,
It is for oral administration to can be used as carminative, for headache and nose, pharynx, laryngitis etc..
The pharmacology of pharyngitis mouth-sucking tablet of the present invention: monarch drug in a prescription is honeysuckle, chrysanthemum, wild chrysanthemum, blackberry lily；Wherein, honeysuckle: property
Sweet, cold, clearing heat and detoxicating, anti-inflammatory detumescence has resisting pathogenic microbes, antitoxin, anti-inflammatory, antipyretic, promotion inflammatory cell phagocytic function；Chrysanthemum
Flower: bitter, sweet, cold nature, relieve heat heat-clearing, calming the liver and improving eyesight have relieving the exterior syndrome with drugs pungent in flavor and cool in property drug effect；Wild chrysanthemum: bitter, sweet, cold in nature, heat-clearing solution
Poison, detumescence, removing heat in the liver for improving eyesight, there is clearing heat-fire drug effect；Blackberry lily: cold in nature, bitter.Clearing heat and detoxicating, dissolving phlegm, relieving sore-throat have clearing heat and detoxicating
Drug effect.Ministerial drug is radix scutellariae, caulis akebiae；Wherein, radix scutellariae: bitter, cold in nature, heat-clearing and damp-drying drug, purging fire for removing toxin, hemostasis, miscarriage prevention belong to antipyretic
The heat-clearing and damp-drying drug of subordinate's classification；Caulis akebiae: it is bitter, it trembles with fear, clearing away the heart-fire, diuresis.Adjutant is Radix Ophiopogonis, asparagus fern, campanulaceae；Wherein, Radix Ophiopogonis:
Cold nature, sweet in flavor, slight bitter, nourishing Yin and promoting production of body fluid, moistening lung and clearing away the heart-fire；Asparagus fern: cold in nature, sweet in flavor, bitter, nourishing yin to moisten dryness, moistening lung and producing body fluid；Campanulaceae:
Bitter, pungent, mild-natured, promoting the dispersing function of the lung, relieving sore-throat, eliminating the phlegm, apocenosis.Make medicine caulis lonicerae, Radix Glycyrrhizae；Wherein, caulis lonicerae: it is sweet, it trembles with fear, heat-clearing solution
Poison, dispelling wind dredging collateral are used for warm disease heating, toxic-heat and blood stasis, beriberoid pyretic arthralgia, redness and swelling of joints heat pain；Radix Glycyrrhizae: it is mild-natured, it is sweet in flavor.Return heart
Through, stomach meridian, the spleen channel, lung channel, invigorate the spleen and benefit qi, cough-relieving apophlegmatic, emergency analgesic therapy, mediation property of medicine, belong to the Qi-tonifying drug classified under qi-restoratives medicine.
In addition menthol is added, there is the effect of dispelling wind, heat-clearing, removing toxic substances, alleviates the diseases such as headache and hot eyes, affection of exogenous wind-heat, pharynx tooth swelling and pain.This
It invents the pharyngitis mouth-sucking tablet and is taken in formulation manufacturing processes and chrysanthemum, wild chrysanthemum medicinal material are first passed through extraction by steam distillation and waved
Water is carried out after hair oil again to mention, so as to improve the clearing heat and detoxicating effect and treatment of chrysanthemum, wild chrysanthemum when treating acute, chronic pharyngitis
Sore, removing toxic substances, detumescence effect.
The application method of pharyngitis mouth-sucking tablet of the present invention: it is buccal, 1 piece/times, 5-8 piece/day.
Hereinafter citing preparation will be carried out using the crude drug embodiment 1,2,3,4,5 of 5 kinds of various doses.
Embodiment 1
Pharyngitis mouth-sucking tablet described in the present embodiment is made of the raw material of following quality proportionings:
Honeysuckle 120g, chrysanthemum 72g, wild chrysanthemum 72g, blackberry lily 100g, radix scutellariae 100g, caulis akebiae 100g, Radix Ophiopogonis 1000g, day
Winter 100g, campanulaceae 80g, caulis lonicerae 120g, Radix Glycyrrhizae 80g, menthol 0.132g.
The preparation method of pharyngitis mouth-sucking tablet described in the present embodiment, specifically comprises the following steps:
(1) each raw material, honeysuckle 120g, chrysanthemum 72g, wild chrysanthemum 72g, blackberry lily 100g, radix scutellariae are weighed by quality proportioning
100g, caulis akebiae 100g, Radix Ophiopogonis 1000g, asparagus fern 100g, campanulaceae 80g, caulis lonicerae 120g, Radix Glycyrrhizae 80g, menthol 0.132g, to
With；
(2) the weighed 72g chrysanthemum of step (1) and 72g wild chrysanthemum are passed through into extraction by steam distillation volatile oil, it is spare,
The chrysanthemum dregs of a decoction and the wild chrysanthemum dregs of a decoction are obtained simultaneously, spare, the method that the chrysanthemum, wild chrysanthemum extract volatile oil is to use vapor
The way of distillation；The concrete operation method of the steam distillation is to soak above-mentioned chrysanthemum, wild chrysanthemum, puts into multi-function extractor
In, upper cover and exhaust-valve are closed, opens and receives oil valve, slowly opens straight air valve, pressure is no more than 0.02mpa, interlayer air valve pressure
No more than 0.03mpa, cooling water inlet valve and oil water separator liquid feed valve are opened, closes oil water separator blowdown valve；It closes true
Air valve is collected 3 hours to there is volatile oil appearance in oil water separator using indirect steam, obtains the mixing of chrysanthemum and wild chrysanthemum
Volatile oil, it is spare；
(3) the chrysanthemum dregs of a decoction and the wild chrysanthemum dregs of a decoction that obtain step (2) and honeysuckle 120g, blackberry lily 100g, radix scutellariae 100g,
After caulis akebiae 100g, Radix Ophiopogonis 1000g, asparagus fern 100g, campanulaceae 80g, caulis lonicerae 120g, Radix Glycyrrhizae 80g mixing, adds water to cook twice, receive
Collecting decoction liquor, filtrate is obtained after filtering, filtrate is concentrated into the thick paste that relative density is 1.29-1.31, and it is spare, it is described to decoct twice
It boils, wherein the mass ratio of raw material and water is 1:5 in decocting for the first time, and first time decocting time is 2 hours, after decoction
Filtering, obtains the first time dregs of a decoction and first time decoction liquor；The mass ratio of the first time dregs of a decoction and water is 1:3 in second of decoction,
Second of decocting time is 1.5 hours, filters after decoction, obtains second of dregs of a decoction and second of decoction liquor；Merge first
Secondary decoction liquor and second of decoction liquor obtain decoction liquor described in step (3)；
(4) thick paste that step (3) obtains is mixed with powdered glucose, particle is made after mixing, dried, the thick paste
Mixing quality ratio with powdered glucose is 4:3, and the granularity of the particle is 40 mesh, and the temperature of the drying is controlled at 50 DEG C,
The particle drying is to 3% or less moisture weight；
(5) 0.132g menthol is dissolved in 1.3L ethyl alcohol, is adsorbed with aluminium hydroxide, be sieved, obtain the ethyl alcohol of menthol
Solution, the ethyl alcohol are dehydrated alcohol；The dosage of the aluminium hydroxide is 2.37Kg；The sieving is the sieve of 40 mesh；
(6) ethanol solution of the particle that step (4) obtains and the menthol that step (5) obtains is uniformly mixed, sprays into step
Suddenly the volatile oil that (2) are extracted seals 1.5 hours, is pressed into 400 pharyngitis mouth-sucking tablets.
Embodiment 2
Pharyngitis mouth-sucking tablet described in the present embodiment is made of the raw material of following quality proportionings:
Honeysuckle 100g, chrysanthemum 80g, wild chrysanthemum 82g, blackberry lily 90g, radix scutellariae 110g, caulis akebiae 110g, Radix Ophiopogonis 950g, asparagus fern
110g, campanulaceae 90g, caulis lonicerae 130g, Radix Glycyrrhizae 90g, menthol 0.140g.
The preparation method of pharyngitis mouth-sucking tablet described in the present embodiment, specifically comprises the following steps:
(1) each raw material, honeysuckle 100g, chrysanthemum 80g, wild chrysanthemum 82g, blackberry lily 90g, radix scutellariae are weighed by quality proportioning
110g, caulis akebiae 110g, Radix Ophiopogonis 950g, asparagus fern 110g, campanulaceae 90g, caulis lonicerae 130g, Radix Glycyrrhizae 90g, menthol 0.140g, for use；
(2) the weighed 80g chrysanthemum of step (1) and 82g wild chrysanthemum are passed through into extraction by steam distillation volatile oil, it is spare,
The chrysanthemum dregs of a decoction and the wild chrysanthemum dregs of a decoction are obtained simultaneously, spare, the method that the chrysanthemum, wild chrysanthemum extract volatile oil is to use vapor
The way of distillation；The concrete operation method of the steam distillation is to soak above-mentioned chrysanthemum, wild chrysanthemum, puts into multi-function extractor
In, upper cover and exhaust-valve are closed, opens and receives oil valve, slowly opens straight air valve, pressure is no more than 0.02mpa, interlayer air valve pressure
No more than 0.03mpa, cooling water inlet valve and oil water separator liquid feed valve are opened, closes oil water separator blowdown valve；It closes true
Air valve is collected 3 hours to there is volatile oil appearance in oil water separator using indirect steam, obtains the mixing of chrysanthemum and wild chrysanthemum
Volatile oil, it is spare；
(3) the chrysanthemum dregs of a decoction and the wild chrysanthemum dregs of a decoction that obtain step (2) and honeysuckle 100g, blackberry lily 90g, radix scutellariae 110g,
After caulis akebiae 110g, Radix Ophiopogonis 950g, asparagus fern 110g, campanulaceae 90g, caulis lonicerae 130g, Radix Glycyrrhizae 90g mixing, adds water to cook twice, collect
Decoction liquor obtains filtrate after filtering, filtrate is concentrated into the thick paste that relative density is 1.29-1.31, spare, described to decoct twice,
Wherein, the mass ratio of raw material and water is 1:5 in decocting for the first time, and first time decocting time is 1.5 hours, mistake after decoction
Filter, obtains the first time dregs of a decoction and first time decoction liquor；The mass ratio of the first time dregs of a decoction and water is 1:3 in second of decoction, the
Secondary decocting time is 1 hour, filters after decoction, obtains second of dregs of a decoction and second of decoction liquor；Merge and decocts for the first time
Boil liquid and second of decoction liquor obtain decoction liquor described in step (3)；
(4) thick paste that step (3) obtains is mixed with powdered glucose, particle is made after mixing, dried, the thick paste
Mixing quality ratio with powdered glucose is 4:3, and the granularity of the particle is 50 mesh, and the temperature of the drying is controlled at 40 DEG C,
The particle drying is to 3% or less moisture weight；
(5) 0.140g menthol is dissolved in 1.4L ethyl alcohol, is adsorbed with aluminium hydroxide, be sieved, obtain the ethyl alcohol of menthol
Solution, the ethyl alcohol are dehydrated alcohol；The dosage of the aluminium hydroxide is 2.52kg；The sieving is the sieve of 50 mesh；
(6) ethanol solution of the particle that step (4) obtains and the menthol that step (5) obtains is uniformly mixed, sprays into step
Suddenly the volatile oil that (2) are extracted seals 1 hour, is pressed into 350 pharyngitis mouth-sucking tablets.
Embodiment 3
Pharyngitis mouth-sucking tablet described in the present embodiment is made of the raw material of following quality proportionings:
Honeysuckle 130g, chrysanthemum 65g, wild chrysanthemum 65g, blackberry lily 100g, radix scutellariae 100g, caulis akebiae 100g, Radix Ophiopogonis 1000g, day
Winter 90g, campanulaceae 80g, caulis lonicerae 110g, Radix Glycyrrhizae 70g, menthol 0.120g.
The preparation method of pharyngitis mouth-sucking tablet described in the present embodiment, specifically comprises the following steps:
(1) each raw material, honeysuckle 130g, chrysanthemum 65g, wild chrysanthemum 65g, blackberry lily 100g, radix scutellariae are weighed by quality proportioning
100g, caulis akebiae 100g, Radix Ophiopogonis 1000g, asparagus fern 90g, campanulaceae 80g, caulis lonicerae 110g, Radix Glycyrrhizae 70g, menthol 0.120g, for use；
(2) the weighed 65g chrysanthemum of step (1) and 65g wild chrysanthemum are passed through into extraction by steam distillation volatile oil, it is spare,
The chrysanthemum dregs of a decoction and the wild chrysanthemum dregs of a decoction are obtained simultaneously, spare, the method that the chrysanthemum, wild chrysanthemum extract volatile oil is to use vapor
The way of distillation；The concrete operation method of the steam distillation is to soak above-mentioned chrysanthemum, wild chrysanthemum, puts into multi-function extractor
In, upper cover and exhaust-valve are closed, opens and receives oil valve, slowly opens straight air valve, pressure is no more than 0.02mpa, interlayer air valve pressure
No more than 0.03mpa, cooling water inlet valve and oil water separator liquid feed valve are opened, closes oil water separator blowdown valve；It closes true
Air valve is collected 3 hours to there is volatile oil appearance in oil water separator using indirect steam, obtains the mixing of chrysanthemum and wild chrysanthemum
Volatile oil, it is spare；
(3) the chrysanthemum dregs of a decoction and the wild chrysanthemum dregs of a decoction that obtain step (2) and honeysuckle 130g, blackberry lily 100g, radix scutellariae 100g,
After caulis akebiae 100g, Radix Ophiopogonis 1000g, asparagus fern 90g, campanulaceae 80g, caulis lonicerae 110g, Radix Glycyrrhizae 70g mixing, adds water to cook twice, collect
Decoction liquor obtains filtrate after filtering, filtrate is concentrated into the thick paste that relative density is 1.29-1.31, spare, described to decoct twice,
Wherein, the mass ratio of raw material and water is 1:5 in decocting for the first time, and first time decocting time is 2.5 hours, mistake after decoction
Filter, obtains the first time dregs of a decoction and first time decoction liquor；The mass ratio of the first time dregs of a decoction and water is 1:3 in second of decoction, the
Secondary decocting time is 2 hours, filters after decoction, obtains second of dregs of a decoction and second of decoction liquor；Merge and decocts for the first time
Boil liquid and second of decoction liquor obtain decoction liquor described in step (3)；
(4) thick paste that step (3) obtains is mixed with powdered glucose, particle is made after mixing, dried, the thick paste
Mixing quality ratio with powdered glucose is 4:3, and the granularity of the particle is 60 mesh, and the temperature of the drying is controlled at 60 DEG C,
The particle drying is to 3% or less moisture weight；
(5) 0.120g menthol is dissolved in 1.2L ethyl alcohol, is adsorbed with aluminium hydroxide, be sieved, obtain the ethyl alcohol of menthol
Solution, the ethyl alcohol are dehydrated alcohol；The dosage of the aluminium hydroxide is 2.16kg；The sieving is the sieve of 60 mesh；
(6) ethanol solution of the particle that step (4) obtains and the menthol that step (5) obtains is uniformly mixed, sprays into step
Suddenly the volatile oil that (2) are extracted seals 1.5 hours, is pressed into 450 pharyngitis mouth-sucking tablets.
Embodiment 4
Pharyngitis mouth-sucking tablet described in the present embodiment is made of the raw material of following quality proportionings:
Honeysuckle 120g, chrysanthemum 70g, wild chrysanthemum 70g, blackberry lily 110g, radix scutellariae 90g, caulis akebiae 90g, Radix Ophiopogonis 1050g, asparagus fern
100g, campanulaceae 70g, caulis lonicerae 100g, Radix Glycyrrhizae 80g, menthol 0.110g.
The preparation method of pharyngitis mouth-sucking tablet described in the present embodiment, specifically comprises the following steps:
(1) each raw material, honeysuckle 120g, chrysanthemum 70g, wild chrysanthemum 70g, blackberry lily 110g, radix scutellariae are weighed by quality proportioning
90g, caulis akebiae 90g, Radix Ophiopogonis 1050g, asparagus fern 100g, campanulaceae 70g, caulis lonicerae 100g, Radix Glycyrrhizae 80g, menthol 0.110g, for use；
(2) the weighed 70g chrysanthemum of step (1) and 70g wild chrysanthemum are passed through into extraction by steam distillation volatile oil, it is spare,
The chrysanthemum dregs of a decoction and the wild chrysanthemum dregs of a decoction are obtained simultaneously, spare, the method that the chrysanthemum, wild chrysanthemum extract volatile oil is to use vapor
The way of distillation；The concrete operation method of the steam distillation is to soak above-mentioned chrysanthemum, wild chrysanthemum, puts into multi-function extractor
In, upper cover and exhaust-valve are closed, opens and receives oil valve, slowly opens straight air valve, pressure is no more than 0.02mpa, interlayer air valve pressure
No more than 0.03mpa, cooling water inlet valve and oil water separator liquid feed valve are opened, closes oil water separator blowdown valve；It closes true
Air valve is collected 3 hours to there is volatile oil appearance in oil water separator using indirect steam, obtains the mixing of chrysanthemum and wild chrysanthemum
Volatile oil, it is spare；
(3) the chrysanthemum dregs of a decoction and the wild chrysanthemum dregs of a decoction that obtain step (2) and honeysuckle 120g, blackberry lily 110g, radix scutellariae 90g,
After caulis akebiae 90g, Radix Ophiopogonis 1050g, asparagus fern 100g, campanulaceae 70g, caulis lonicerae 100g, Radix Glycyrrhizae 80g mixing, adds water to cook twice, collect
Decoction liquor obtains filtrate after filtering, filtrate is concentrated into the thick paste that relative density is 1.29-1.31, spare, described to decoct twice,
Wherein, the mass ratio of raw material and water is 1:5 in decocting for the first time, and first time decocting time is 2.5 hours, mistake after decoction
Filter, obtains the first time dregs of a decoction and first time decoction liquor；The mass ratio of the first time dregs of a decoction and water is 1:3 in second of decoction, the
Secondary decocting time is 1 hour, filters after decoction, obtains second of dregs of a decoction and second of decoction liquor；Merge and decocts for the first time
Boil liquid and second of decoction liquor obtain decoction liquor described in step (3)；
(4) thick paste that step (3) obtains is mixed with powdered glucose, particle is made after mixing, dried, the thick paste
Mixing quality ratio with powdered glucose is 4:3, and the granularity of the particle is 50 mesh, and the temperature of the drying is controlled at 40 DEG C,
The particle drying is to 3% or less moisture weight；
(5) 0.110g menthol is dissolved in 1.1L ethyl alcohol, is adsorbed with aluminium hydroxide, be sieved, obtain the ethyl alcohol of menthol
Solution, the ethyl alcohol are dehydrated alcohol；The dosage of the aluminium hydroxide is 1.98kg；The sieving is the sieve of 50 mesh；
(6) ethanol solution of the particle that step (4) obtains and the menthol that step (5) obtains is uniformly mixed, sprays into step
Suddenly the volatile oil that (2) are extracted seals 1.2 hours, is pressed into 420 pharyngitis mouth-sucking tablets.
Embodiment 5
Pharyngitis mouth-sucking tablet described in the present embodiment is made of the raw material of following quality proportionings:
Honeysuckle 120g, chrysanthemum 70g, wild chrysanthemum 70g, blackberry lily 100g, radix scutellariae 100g, caulis akebiae 105g, Radix Ophiopogonis 1050g, day
Winter 105g, campanulaceae 85g, caulis lonicerae 120g, Radix Glycyrrhizae 85g, menthol 0.115g.
The preparation method of pharyngitis mouth-sucking tablet described in the present embodiment, specifically comprises the following steps:
(1) each raw material, honeysuckle 120g, chrysanthemum 70g, wild chrysanthemum 70g, blackberry lily 100g, radix scutellariae are weighed by quality proportioning
100g, caulis akebiae 105g, Radix Ophiopogonis 1050g, asparagus fern 105g, campanulaceae 85g, caulis lonicerae 120g, Radix Glycyrrhizae 85g, menthol 0.115g, to
With；
(2) the weighed 70g chrysanthemum of step (1) and 70g wild chrysanthemum are passed through into extraction by steam distillation volatile oil, it is spare,
The chrysanthemum dregs of a decoction and the wild chrysanthemum dregs of a decoction are obtained simultaneously, spare, the method that the chrysanthemum, wild chrysanthemum extract volatile oil is to use vapor
The way of distillation；The concrete operation method of the steam distillation is to soak above-mentioned chrysanthemum, wild chrysanthemum, puts into multi-function extractor
In, upper cover and exhaust-valve are closed, opens and receives oil valve, slowly opens straight air valve, pressure is no more than 0.02mpa, interlayer air valve pressure
No more than 0.03mpa, cooling water inlet valve and oil water separator liquid feed valve are opened, closes oil water separator blowdown valve；It closes true
Air valve is collected 3 hours to there is volatile oil appearance in oil water separator using indirect steam, obtains the mixing of chrysanthemum and wild chrysanthemum
Volatile oil, it is spare；
(3) the chrysanthemum dregs of a decoction and the wild chrysanthemum dregs of a decoction that obtain step (2) and honeysuckle 120g, blackberry lily 100g, radix scutellariae 100g,
After caulis akebiae 105g, Radix Ophiopogonis 1050g, asparagus fern 105g, campanulaceae 85g, caulis lonicerae 120g, Radix Glycyrrhizae 85g mixing, adds water to cook twice, receive
Collecting decoction liquor, filtrate is obtained after filtering, filtrate is concentrated into the thick paste that relative density is 1.29-1.31, and it is spare, it is described to decoct twice
It boils, wherein the mass ratio of raw material and water is 1:5 in decocting for the first time, and first time decocting time is 2 hours, after decoction
Filtering, obtains the first time dregs of a decoction and first time decoction liquor；The mass ratio of the first time dregs of a decoction and water is 1:3 in second of decoction,
Second of decocting time is 1.5 hours, filters after decoction, obtains second of dregs of a decoction and second of decoction liquor；Merge first
Secondary decoction liquor and second of decoction liquor obtain decoction liquor described in step (3)；
(4) thick paste that step (3) obtains is mixed with powdered glucose, particle is made after mixing, dried, the thick paste
Mixing quality ratio with powdered glucose is 4:3, and the granularity of the particle is 40 mesh, and the temperature of the drying is controlled at 55 DEG C,
The particle drying is to 3% or less moisture weight；
(5) 0.115g menthol is dissolved in 1.15L ethyl alcohol, is adsorbed with aluminium hydroxide, be sieved, obtain the ethyl alcohol of menthol
Solution, the ethyl alcohol are dehydrated alcohol；The dosage of the aluminium hydroxide is 2.07kg；The sieving is the sieve of 40 mesh；
(6) ethanol solution of the particle that step (4) obtains and the menthol that step (5) obtains is uniformly mixed, sprays into step
Suddenly the volatile oil that (2) are extracted seals 1 hour, is pressed into 380 pharyngitis mouth-sucking tablets.
6 clinical test of embodiment
1 general information
100 pharyngitis patients are observed, wherein women 50, male 50, the range of age: 30-35 years old.
2 diagnostic criteria
Symptom: pharyngalgia, dry throat, pharynx itch, occasionally have nausea, cough, pharyngitis.
3 are included in standard
Pharyngitis patient course of disease person within 1 year, the age is between 30-35 years old.
4 evaluation criteria
Recovery from illness: pharyngalgia, cough disappear, and the symptoms were significantly improved for pharyngitis.
Effective: pharyngalgia, cough are clearly better, and pharyngitis symptom is improved.
Effective: pharyngalgia, cough are improved, and the variation of pharyngitis symptom is little.
Invalid: pharyngalgia, cough, pharyngitis symptom without improvement or aggravate.
5 treatment methods
Give pharyngitis mouth-sucking tablet described in the embodiment of the present invention 1 treatment, it is buccal, 1 piece/times, 8 pieces/day, at interval of 2 hours 1.
6 results
By treatment in 30 days, clinical efficacy was shown in Table 1.
The clinical effectiveness of the pharyngitis mouth-sucking tablet of the present invention of table 1 counts
As shown in Table 1, after treatment in 30 days, the present invention is 52% to the cure rate of pharyngitis patient, and total effective rate is
94%, the results showed that, pharyngitis mouth-sucking tablet of the present invention has preferable therapeutic effect to pharyngitis.
Typical case
Mr. Wang, female, the age 35 years old, pharyngitis medical history 8 months, symptom: pharyngalgia, cough, pharyngitis gave the embodiment of the present invention 1
Prepared pharyngitis mouth-sucking tablet treatment, takes pharyngitis mouth-sucking tablet 30 days, and pharyngalgia, cough are clearly better, and pharyngitis symptom is improved.
Zhao, female, the age 40 years old, pharyngitis medical history 1 year, symptom: cough, pharyngitis were given prepared by the embodiment of the present invention 1
Pharyngitis mouth-sucking tablet treatment, takes pharyngitis mouth-sucking tablet 30 days, and cough disappears, and the symptoms were significantly improved for pharyngitis.
Lee, male 34 years old, the length of smoking 5 years, pharyngitis medical history 2 years, symptom: it is made to give the embodiment of the present invention 1 for cough, pharyngitis
Standby pharyngitis mouth-sucking tablet treatment, takes pharyngitis mouth-sucking tablet 30 days, cough is clearly better, and pharyngitis symptom is improved.
The above content is specific preferred embodiment further description to made by the present invention is combined, cannot recognize
Fixed specific implementation of the invention is only limitted to these explanations.For those skilled in the art, do not taking off
Under the premise of from present inventive concept, several simple deduction or replace can also be made, all should be considered as and belong to protection of the invention
Range.
Claims (7)
1. a kind of pharyngitis mouth-sucking tablet, which is characterized in that be made of the raw material of following quality proportionings: honeysuckle 100-130g, chrysanthemum 65-
80g, wild chrysanthemum 65-82g, blackberry lily 90-110g, radix scutellariae 90-110g, caulis akebiae 90-110g, Radix Ophiopogonis 950-1050g, asparagus fern 90-
110g, campanulaceae 70-90g, caulis lonicerae 100-130g, Radix Glycyrrhizae 70-90g, menthol 0.110-0.140g.
2. pharyngitis mouth-sucking tablet according to claim 1, which is characterized in that the quality proportioning of each raw material are as follows: honeysuckle 120g,
Chrysanthemum 72g, wild chrysanthemum 72g, blackberry lily 100g, radix scutellariae 100g, caulis akebiae 100g, Radix Ophiopogonis 1000g, asparagus fern 100g, campanulaceae 80g, honeysuckle
Rattan 120g, Radix Glycyrrhizae 80g, menthol 0.132g.
3. the preparation method of pharyngitis mouth-sucking tablet as claimed in claim 1 or 2, which comprises the steps of:
(1) each raw material, honeysuckle 100-130g, chrysanthemum 65-80g, wild chrysanthemum 65-82g, blackberry lily 90- are weighed by quality proportioning
110g, radix scutellariae 90-110g, caulis akebiae 90-110g, Radix Ophiopogonis 950-1050g, asparagus fern 90-110g, campanulaceae 70-90g, caulis lonicerae 100-
130g, Radix Glycyrrhizae 70-90g, menthol 0.110-0.140g, for use；
(2) standby by the weighed 65-80g chrysanthemum of step (1) and 65-82g wild chrysanthemum by extraction by steam distillation volatile oil
With, while the chrysanthemum dregs of a decoction and the wild chrysanthemum dregs of a decoction are obtained, it is spare；
(3) the chrysanthemum dregs of a decoction and the wild chrysanthemum dregs of a decoction and honeysuckle 100-130g, blackberry lily 90-110g, radix scutellariae obtained step (2)
90-110g, caulis akebiae 90-110g, Radix Ophiopogonis 950-1050g, asparagus fern 90-110g, campanulaceae 70-90g, caulis lonicerae 100-130g, Radix Glycyrrhizae
It after 70-90g mixing, adds water to cook twice, collects decoction liquor, filtrate is obtained after filtering, it is 1.29- that filtrate, which is concentrated into relative density,
1.31 thick paste, it is spare；
(4) thick paste that step (3) obtains is mixed with powdered glucose, particle is made after mixing, dried, the thick paste and Portugal
The mixing quality ratio of grape Icing Sugar is 4:3；
(5) 0.110-0.140g menthol is dissolved in ethyl alcohol, is adsorbed with aluminium hydroxide, is sieved, the ethyl alcohol for obtaining menthol is molten
Liquid；
(6) ethanol solution of the particle that step (4) obtains and the menthol that step (5) obtains is uniformly mixed, is sprayed into step (2)
The volatile oil of extraction seals 1-1.5 hours, is pressed into 350-450 piece pharyngitis mouth-sucking tablet.
4. the preparation method of pharyngitis mouth-sucking tablet according to claim 3, it is characterised in that: step (2) chrysanthemum, wild chrysanthemum mention
The method for taking volatile oil is using steam distillation；The concrete operation method of the steam distillation be by above-mentioned chrysanthemum,
Wild chrysanthemum wetting, puts into multi-function extractor, closes upper cover and exhaust-valve, opens and receives oil valve, slowly opens straight air valve, pressure
No more than 0.02mpa, interlayer air valve pressure is no more than 0.03mpa, opens cooling water inlet valve and oil water separator liquid feed valve, closes
Close oil water separator blowdown valve；True air valve is closed, it is small to collect 3 to there is volatile oil appearance in oil water separator using indirect steam
When, the Mixed chaotic sequences of chrysanthemum and wild chrysanthemum are obtained, it is spare.
5. the preparation method of pharyngitis mouth-sucking tablet according to claim 3, it is characterised in that: step (3) is described to be decocted twice,
In, the mass ratio of raw material and water is 1:5 in decoction for the first time, and first time decocting time is 1.5-2.5 hours, after decoction
Filtering, obtains the first time dregs of a decoction and first time decoction liquor；The mass ratio of the first time dregs of a decoction and water is 1:3 in second of decoction,
Second of decocting time is 1-2 hours, filters after decoction, obtains second of dregs of a decoction and second of decoction liquor；Merge first
Secondary decoction liquor and second of decoction liquor obtain decoction liquor described in step (3).
6. the preparation method of pharyngitis mouth-sucking tablet according to claim 3, it is characterised in that: the granularity of step (4) described particle is
40-60 mesh, the temperature of the drying are controlled at 40-60 DEG C, the particle drying to 3% or less moisture weight.
7. the preparation method of pharyngitis mouth-sucking tablet according to claim 3, it is characterised in that: step (5) sieving is 40-60 mesh
Sieve.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115645490A (en) * | 2022-12-12 | 2023-01-31 | 元和药业股份有限公司 | Tablet for pharyngitis and preparation method thereof |
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| CN102357213A (en) * | 2011-10-24 | 2012-02-22 | 宁夏金太阳药业有限公司 | Method for preparing nasosinusitis particles without cane sugar |
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| CN102357213A (en) * | 2011-10-24 | 2012-02-22 | 宁夏金太阳药业有限公司 | Method for preparing nasosinusitis particles without cane sugar |
| CN105535439A (en) * | 2016-01-19 | 2016-05-04 | 宁夏金太阳药业有限公司 | Traditional Chinese medicinal composition for treating pharyngitis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115645490A (en) * | 2022-12-12 | 2023-01-31 | 元和药业股份有限公司 | Tablet for pharyngitis and preparation method thereof |
| CN115645490B (en) * | 2022-12-12 | 2023-05-16 | 元和药业股份有限公司 | Tablet for pharyngitis and preparation method thereof |
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Application publication date: 20190809 |