CN111097021A - Traditional Chinese medicine composition for treating mild and suspected new coronary pneumonia and acute respiratory infection - Google Patents

Traditional Chinese medicine composition for treating mild and suspected new coronary pneumonia and acute respiratory infection Download PDF

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CN111097021A
CN111097021A CN202010095600.6A CN202010095600A CN111097021A CN 111097021 A CN111097021 A CN 111097021A CN 202010095600 A CN202010095600 A CN 202010095600A CN 111097021 A CN111097021 A CN 111097021A
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traditional chinese
chinese medicine
raw materials
fried
medicine composition
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曹利平
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    • A61K36/185—Magnoliopsida (dicotyledons)
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Abstract

The invention relates to a traditional Chinese medicine composition for treating slight and suspected new coronary pneumonia and acute respiratory infection, which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 10-20g of honeysuckle, 10-20g of fructus forsythiae, 10-20g of folium isatidis, 10-20g of radix scrophulariae, 6-15g of fried bitter almond, 10-20g of thunberg fritillary bulb, 6-15g of platycodon grandiflorum, 6-15g of perilla leaf, 6-15g of radix sileris, 10-20g of bran-fried bighead atractylodes rhizome, 10-20g of poria cocos, 10-20g of capillary wormwood, 10-20g of codonopsis pilosula, 6-15g of lophatherum gracile, 10-20g of radix ophiopogonis and 4-10g of raw liquorice; the preparation method of the fried bitter almond comprises the steps of frying bitter almond; the preparation method of the bran-fried bighead atractylodes rhizome comprises the steps of heating raw bighead atractylodes rhizome, adding wheat bran, frying until the color becomes brown; taking the traditional Chinese medicine raw materials in parts by weight, decocting the raw materials in water for 30 minutes, and taking 400ML of juice. The traditional Chinese medicine composition has the characteristics of simultaneous treatment of exterior and interior, combined administration of clear and tonic, and prevention of diseases and transformation, has definite curative effect on respiratory infectious diseases in winter and spring, and improves symptoms of running nose, fever, cough, dry throat, pharyngalgia, expectoration, poor diet and short breath before and after a patient takes the medicine.

Description

Traditional Chinese medicine composition for treating mild and suspected new coronary pneumonia and acute respiratory infection
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating slight and suspected new coronary pneumonia and acute respiratory infection.
Background
70-80% of acute upper respiratory tract infections are caused by viruses. Including rhinoviruses, coronaviruses, adenoviruses, influenza and parainfluenza viruses, respiratory syncytial viruses, echoviruses, coxsackie viruses, and the like. Another 20-30% is caused by bacteria. Bacterial infections may be either direct or secondary to viral infections, with hemolytic streptococci being the most common, followed by haemophilus influenzae, pneumococcus, staphylococci, etc., and occasionally gram-negative bacteria. Pneumonia of new coronavirus infection is lung inflammation caused by new coronavirus (nCoV) infection, and the world health organization names the new coronavirus as "COVID-19", clinical symptoms: it is manifested as fever, fatigue, dry cough, and dyspnea in severe cases.
The traditional western medicines for treating acute upper respiratory tract infection and novel coronavirus infection pneumonia mainly adopt broad-spectrum antibiotics and syndrome symptomatic treatment, have a certain curative effect on the pneumonia, but are not ideal enough for relieving partial symptoms, and have great side effects after long-term administration.
To solve this problem, the present invention is hereby proposed.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating mild new coronary pneumonia, suspected patients and acute respiratory infection.
In order to realize the purposes, the following technical scheme is adopted:
the traditional Chinese medicine composition for treating mild new coronary pneumonia, suspected patients and acute respiratory infection is prepared from the following traditional Chinese medicine raw materials in parts by weight: 10-20g of honeysuckle, 10-20g of fructus forsythiae, 10-20g of folium isatidis, 10-20g of radix scrophulariae, 6-15g of fried bitter almond, 10-20g of thunberg fritillary bulb, 6-15g of platycodon grandiflorum, 6-15g of perilla leaf, 6-15g of radix sileris, 10-20g of bran-fried bighead atractylodes rhizome, 10-20g of poria cocos, 10-20g of capillary wormwood, 10-20g of codonopsis pilosula, 6-15g of lophatherum gracile, 10-20g of radix ophiopogonis and 4-10g of raw liquorice.
Preferably, the traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 15g of honeysuckle, 15g of fructus forsythiae, 15g of folium isatidis, 15g of radix scrophulariae, 10g of fried bitter almond, 15g of thunberg fritillary bulb, 10g of platycodon grandiflorum, 10g of perilla leaf, 10g of radix sileris, 15g of bran-fried bighead atractylodes rhizome, 15g of poria cocos, 15g of capillary wormwood, 15g of codonopsis pilosula, 10g of lophatherum gracile, 15g of radix ophiopogonis and 6g of raw liquorice.
Further, the preparation method of the fried bitter almond comprises the step of frying the bitter almond.
Further, the preparation method of the bran-fried bighead atractylodes rhizome comprises the steps of heating raw bighead atractylodes rhizome, adding wheat bran, frying, and using the mixture until the color of the mixture turns to brown.
The preparation method of the traditional Chinese medicine composition comprises the steps of taking the traditional Chinese medicine raw materials in parts by weight, decocting the raw materials in water for 30 minutes, and taking 400ML of juice.
The use method comprises the following steps: taking the traditional Chinese medicine raw materials in parts by weight as 1 dose, decocting adult with water 1 dose each day for 30 minutes, and taking 400ML of juice each time, 200ML, 1 hour after breakfast and supper.
The applicant is subjected to intensive clinical research for many years and is analyzed and summarized by combining with clinical application, and the application proves that the Chinese medicinal composition has good curative effects on acute respiratory tract infection, trachitis and pneumonia.
Preferably, the traditional Chinese medicine composition is applied to preparation of a medicine for treating acute respiratory tract infection.
Preferably, the traditional Chinese medicine composition is applied to preparation of a medicine for treating slight coronary pneumonia.
Preferably, the traditional Chinese medicine composition is applied to preparation of medicines for treating suspected new coronary pneumonia.
The pharmacological effects of the raw materials of the traditional Chinese medicines are respectively as follows:
the honeysuckle flower is cold in nature and sweet in taste, and has the effects of clearing away heat and toxic materials, resisting inflammation, tonifying deficiency and treating wind.
Fructus forsythiae is bitter and neutral in taste, and has the effects of clearing heat, removing toxicity, eliminating stagnation and relieving swelling.
Folium Isatidis is bitter in taste and cold in nature, and has effects of clearing heat and detoxicating, cooling blood and resolving macula.
Radix scrophulariae is sweet, bitter, salty and slightly cold, and has the effects of clearing heat and cooling blood, nourishing yin and lowering fire, and detoxifying and resolving masses.
Stir-baked bitter apricot kernels are slightly warm in nature and bitter in taste, and have the effects of depressing qi, relieving cough and asthma, and relaxing bowel.
Zhejiang fritillaria is cold in nature and bitter in taste, and has the effects of clearing heat, resolving masses, reducing phlegm and relieving cough.
Radix Platycodi, neutral in nature, bitter and pungent in taste, has effects of dispersing lung qi, relieving sore throat, eliminating phlegm, and expelling pus.
Perilla leaf, warm in nature and pungent in taste, has the effects of relieving exterior syndrome, dispelling cold, promoting qi circulation and regulating stomach.
Ledebouriella root, pungent and sweet in flavor, slightly warm in nature, has the effects of dispelling wind, relieving exterior syndrome, eliminating dampness, relieving pain and relieving spasm.
Largehead atractylodes rhizome stir-fried with bran has warm property, sweet and bitter taste and has the effects of strengthening spleen, tonifying qi, eliminating dampness and promoting diuresis, suppressing sweating and preventing miscarriage.
Poria cocos, with mild nature, sweet and bland taste, has the effects of promoting diuresis, eliminating dampness, invigorating spleen and calming heart.
Capillary wormwood herb, being slightly cold in nature, bitter and pungent in taste, has the efficacy of clearing damp-heat and eliminating jaundice.
The codonopsis pilosula is sweet and neutral, and has the effects of tonifying qi and promoting the production of body fluid.
Lophatherum gracile, cold in nature, sweet and bland in flavor, has the effects of clearing heat, relieving restlessness and promoting urination.
Radix ophiopogonis is sweet, slightly bitter and slightly cold, and has the effects of nourishing yin, promoting the production of body fluid, moistening lung and relieving cough.
The raw licorice is sweet and mild, and has the effects of tonifying qi and strengthening the middle warmer, relieving spasm and pain, moistening lung and arresting cough, purging fire and removing toxicity, and harmonizing the medicines.
Clinical data:
for showing the treatment effect of the medicine, the patient is treated for respiratory tract infection in winter and spring in 2015, 2016, 2017, 2018 and 2019 within five years from 11 months per year to 2 months per year (2020 to the bottom of 1 month), the outpatient medical records with at least two continuous times are 3672 parts, the initial traditional Chinese medicine prescription is taken for statistics, wherein the related diseases are as follows: acute upper respiratory tract infection 1313 parts (35.76%), bronchitis 1639 parts (44.63%) and pneumonia 720 parts (19.61%).
The main clinical symptoms are: 2415 cases (65.77 percent) of fever, 2051 cases (55.86 percent) of running nose, 2620 case (71.34 percent) of dry throat and sore throat, 3672(100 percent) of cough, 2528 cases (68.87 percent) of expectoration, 1652 cases (44.98 percent) of short breath and 867 cases (23.61 percent) of anorexia.
Through medication, the symptoms of patients are improved: by comparison, the symptoms improved before and after the patient takes the medicine are found to be 2057 (improvement rate 85.21%), 1775 (improvement rate 86.53%), 2197 (improvement rate 83.89%), 3084 (improvement rate 83.99%), 2030 (improvement rate 80.28%), 1256 (improvement rate 77.21%) and 676 (improvement rate 78.00%) of fever improvement cases.
The invention also aims to provide a pharmaceutical composition, which takes the traditional Chinese medicine composition as an effective component and also comprises pharmaceutically acceptable auxiliary materials. The dosage form of the pharmaceutical composition is granules, tablets, capsules, soft capsules and oral liquid. The granule comprises sugar-free granule.
The preparation method of the pharmaceutical composition granules comprises the following steps:
1) weighing the traditional Chinese medicine raw materials in parts by weight, adding 10 times of water, decocting for three times, each time for 1.5 hours, filtering, and combining the filtrates;
2) concentrating the filtrate to obtain thick fluid extract, adding appropriate amount of dextrin into the thick fluid extract, and mixing to obtain mixture;
3) drying and crushing the mixture to form mixture powder, adding a proper amount of dextrin and sucrose powder into the mixture powder, uniformly mixing, preparing into particles, drying, finishing and packaging the particles to obtain finished product particles.
The relative density of the thick clear paste is 1.30-1.35 measured in the environment of 60-65 ℃.
The granule not only maintains the characteristic of rapid action of the decoction, but also overcomes the defect of inconvenient decoction when the decoction is used temporarily; in addition, the granule does not need to prepare the extract of medicinal materials, which is particularly suitable for Chinese herbal compound preparations.
Has the advantages that:
1. the traditional Chinese medicine composition has the characteristics of simultaneous treatment of exterior and interior, simultaneous administration of clear and tonic and prevention of diseases and transformation, has definite curative effect on respiratory infectious diseases in winter and spring, and improves symptoms of running nose, fever, cough, dry throat, sore throat, expectoration, poor diet and short breath before and after a patient takes the medicine.
2. At present, for mild symptoms and suspected symptoms of the novel coronavirus infection, the novel coronavirus infection is caused in winter, mainly causes fever, and initially shows fever, dry cough and hypodynamia, which are similar to the upper-jiao defensive-qi syndrome caused by warm diseases; the occurrence of coma and even death is matched with the 'reverse pass pericardium syndrome' to accord with the development rule of epidemic diseases of 'attack by warm pathogen, first attack of lung and reverse pass pericardium', but the traditional Chinese medicine composition is developed aiming at the 'syndrome of both defensive qi and pathogenic heat obstructing lung', is matched with the syndrome of epidemic situation, if the disease condition can be cut off and turned aiming at mild disease, the further deterioration of the disease is effectively prevented, which has important significance for changing the state of illness of mild disease patients and suspected patients.
3. The preparation method of the granules disclosed by the invention has the advantages that the auxiliary materials are added into the concentrated solution for mixing, drying, crushing and granulating, the drying time is short, and the effective ingredients can be well reserved; meanwhile, dextrin and sucrose which are easy to obtain and cheap are used as auxiliary materials, so that the effects of reducing the moisture-attracting taste and correcting the taste can be achieved.
Detailed Description
Example 1
The traditional Chinese medicine composition for treating mild new coronary pneumonia, suspected patients and acute respiratory infection is prepared from the following traditional Chinese medicine raw materials in parts by weight: 10g of honeysuckle, 10g of fructus forsythiae, 10g of folium isatidis, 10g of radix scrophulariae, 6g of fried bitter almond, 10g of thunberg fritillary bulb, 6g of platycodon grandiflorum, 6g of perilla leaf, 6g of radix sileris, 10g of bran-fried bighead atractylodes rhizome, 10g of poria cocos, 10g of capillary wormwood herb, 10g of codonopsis pilosula, 6g of lophatherum gracile, 10g of radix ophiopogonis and 4g of raw liquorice, decocting the raw materials in parts by weight in water for 30 minutes to obtain 400ML of juice, wherein the juice is 1 dose per day for an adult, each dose of water is decocted for 30 minutes, and the juice is 400ML and is taken 1 hour after breakfast.
Example 2
The traditional Chinese medicine composition for treating mild new coronary pneumonia, suspected patients and acute respiratory infection is prepared from the following traditional Chinese medicine raw materials in parts by weight: 20g of honeysuckle, 20g of fructus forsythiae, 20g of folium isatidis, 20g of radix scrophulariae, 15g of fried bitter almond, 20g of thunberg fritillary bulb, 15g of platycodon grandiflorum, 15g of perilla leaf, 15g of radix sileris, 20g of bran-fried bighead atractylodes rhizome, 20g of poria cocos, 20g of capillary wormwood herb, 20g of codonopsis pilosula, 15g of lophatherum gracile, 20g of radix ophiopogonis and 10g of raw liquorice, decocting the raw materials in parts by weight in water for 30 minutes to obtain 400ML of juice, wherein the juice is 1 dose per day for an adult, each dose of water is decocted for 30 minutes, and the juice is 400ML and is taken 1 hour after breakfast.
Example 3
The traditional Chinese medicine composition for treating mild new coronary pneumonia, suspected patients and acute respiratory infection is prepared from the following traditional Chinese medicine raw materials in parts by weight: 15g of honeysuckle, 15g of fructus forsythiae, 15g of folium isatidis, 15g of radix scrophulariae, 10g of fried bitter almond, 15g of thunberg fritillary bulb, 10g of platycodon grandiflorum, 10g of perilla leaf, 10g of radix sileris, 15g of bran-fried bighead atractylodes rhizome, 15g of poria cocos, 15g of capillary wormwood herb, 15g of codonopsis pilosula, 10g of lophatherum gracile, 15g of radix ophiopogonis and 6g of raw liquorice, decocting the raw materials in parts by weight in water for 30 minutes to obtain 400ML of juice, wherein the juice is 1 dose per day for an adult, each dose of water is decocted for 30 minutes, and the juice is 400ML and is taken 1 hour after breakfast.
In clinic, 3672 parts of outpatients are selected, the traditional Chinese medicine preparation is taken, the symptom improvement condition of the patients is recorded, and the symptoms improved before and after the patients take the medicine are found to be 2057 (improvement rate 85.21%), 1775 (improvement rate 86.53%), 2197 (improvement rate 83.89%), 3084 (improvement rate 83.99%), 2030 (improvement rate 80.28%), 1256 (improvement rate 77.21%) and 676 (improvement rate 78.00%) in sequence.
Therefore, the traditional Chinese medicine composition has good treatment effects on runny nose, fever, cough, dry throat, pharyngalgia, expectoration, poor diet and short breath; at present, for mild symptoms and suspected symptoms of the novel coronavirus infection, the novel coronavirus infection is caused in winter, mainly causes fever, and initially shows fever, dry cough and hypodynamia, which are similar to the upper-jiao defensive-qi syndrome caused by warm diseases; the occurrence of coma and even death is matched with the 'reverse pass pericardium syndrome' to accord with the development rule of epidemic diseases of 'attack by warm pathogen, first attack of lung and reverse pass pericardium', but the traditional Chinese medicine composition is developed aiming at the 'syndrome of both defensive qi and pathogenic heat obstructing lung', is matched with the syndrome of epidemic situation, if the disease condition can be cut off and turned aiming at mild disease, the further deterioration of the disease is effectively prevented, which has important significance for changing the state of illness of mild disease patients and suspected patients.
Example 4
A preparation method of a pharmaceutical composition granule comprises the following steps:
1) weighing 15g of honeysuckle, 15g of fructus forsythiae, 15g of folium isatidis, 15g of radix scrophulariae, 10g of fried bitter almond, 15g of thunberg fritillary bulb, 10g of platycodon grandiflorum, 10g of perilla leaf, 10g of radix sileris, 15g of bran-fried bighead atractylodes rhizome, 15g of poria cocos, 15g of capillary wormwood, 15g of codonopsis pilosula, 10g of lophatherum gracile, 15g of radix ophiopogonis and 6g of raw liquorice, adding 10 times of water into the traditional Chinese medicine raw materials, decocting for three times, 1.5 hours each time, filtering, and combining;
2) concentrating the filtrate to obtain thick fluid extract with relative density of 1.30-1.35 (at 60-65 deg.C), adding appropriate amount of dextrin into the thick fluid extract, and mixing to obtain mixture;
3) drying and crushing the mixture to form mixture powder, adding a proper amount of dextrin and sucrose powder into the mixture powder, uniformly mixing, preparing into particles, drying, finishing and packaging the particles to obtain finished product particles.
Extracting the concentrated solution through the steps, adding auxiliary materials into the concentrated solution, mixing, drying, crushing and granulating, wherein the drying time is short, and effective ingredients can be well reserved; meanwhile, dextrin and sucrose which are easy to obtain and cheap are used as auxiliary materials, so that the effects of reducing the moisture-attracting taste and correcting the taste can be achieved.

Claims (10)

1. The traditional Chinese medicine composition for treating mild new coronary pneumonia, suspected patients and acute respiratory infection is characterized by being prepared from the following traditional Chinese medicine raw materials in parts by weight: 10-20g of honeysuckle, 10-20g of fructus forsythiae, 10-20g of folium isatidis, 10-20g of radix scrophulariae, 6-15g of fried bitter almond, 10-20g of thunberg fritillary bulb, 6-15g of platycodon grandiflorum, 6-15g of perilla leaf, 6-15g of radix sileris, 10-20g of bran-fried bighead atractylodes rhizome, 10-20g of poria cocos, 10-20g of capillary wormwood, 10-20g of codonopsis pilosula, 6-15g of lophatherum gracile, 10-20g of radix ophiopogonis and 4-10g of raw liquorice.
2. The traditional Chinese medicine composition as claimed in claim 1, which is prepared from the following traditional Chinese medicine raw materials in parts by weight: 15g of honeysuckle, 15g of fructus forsythiae, 15g of folium isatidis, 15g of radix scrophulariae, 10g of fried bitter almond, 15g of thunberg fritillary bulb, 10g of platycodon grandiflorum, 10g of perilla leaf, 10g of radix sileris, 15g of bran-fried bighead atractylodes rhizome, 15g of poria cocos, 15g of capillary wormwood, 15g of codonopsis pilosula, 10g of lophatherum gracile, 15g of radix ophiopogonis and 6g of raw liquorice.
3. The Chinese medicinal composition according to claim 1 or 2, wherein the fried bitter apricot seeds are prepared by frying bitter apricot seeds.
4. The Chinese medicinal composition according to claim 1 or 2, wherein the bran-parched Atractylodis rhizoma is prepared by heating raw Atractylodis rhizoma, adding testa Tritici, and parching until the color turns to brown.
5. The preparation method of the traditional Chinese medicine composition according to claim 1 or 2, which is characterized by comprising the following steps: taking the traditional Chinese medicine raw materials in parts by weight, decocting the raw materials in water for 30 minutes, and taking 400ML of juice.
6. The use of the Chinese medicinal composition of claim 1 or 2 in the preparation of a medicament for treating mild new coronary pneumonia, suspected patients and acute respiratory infection.
7. A pharmaceutical composition, which is characterized in that the pharmaceutical composition takes the traditional Chinese medicine composition of any one of claims 1-2 as an effective component and further comprises pharmaceutically acceptable auxiliary materials.
8. The Chinese medicinal composition according to claim 7, wherein the dosage form of the pharmaceutical composition is granules, tablets, capsules, soft capsules or oral liquid.
9. The pharmaceutical composition of claim 8, wherein the preparation method of the granule comprises the following steps:
1) weighing the traditional Chinese medicine raw materials in parts by weight, adding 10 times of water, decocting for three times, each time for 1.5 hours, filtering, and combining the filtrates;
2) concentrating the filtrate to obtain thick fluid extract, adding appropriate amount of dextrin into the thick fluid extract, and mixing to obtain mixture;
3) drying and crushing the mixture to form mixture powder, adding a proper amount of dextrin and sucrose powder into the mixture powder, uniformly mixing, preparing into particles, drying, finishing and packaging the particles to obtain finished product particles.
10. The pharmaceutical composition of claim 9, wherein the thick fluid extract has a relative density of 1.30-1.35 at 60-65 ℃.
CN202010095600.6A 2020-02-17 2020-02-17 Traditional Chinese medicine composition for treating mild and suspected new coronary pneumonia and acute respiratory infection Withdrawn CN111097021A (en)

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CN111569035A (en) * 2020-05-06 2020-08-25 石家庄市第五医院 Traditional Chinese medicine composition and application thereof in preparation of medicine for treating new coronary pneumonia, especially asymptomatic infected patients
CN111569010A (en) * 2020-05-06 2020-08-25 石家庄市第五医院 Traditional Chinese medicine composition and application thereof in preparation of medicine for treating neocoronary pneumonia

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Publication number Priority date Publication date Assignee Title
CN111569035A (en) * 2020-05-06 2020-08-25 石家庄市第五医院 Traditional Chinese medicine composition and application thereof in preparation of medicine for treating new coronary pneumonia, especially asymptomatic infected patients
CN111569010A (en) * 2020-05-06 2020-08-25 石家庄市第五医院 Traditional Chinese medicine composition and application thereof in preparation of medicine for treating neocoronary pneumonia
CN111569035B (en) * 2020-05-06 2021-08-13 石家庄市第五医院 Traditional Chinese medicine composition and application thereof in preparation of medicine for treating new coronary pneumonia, especially asymptomatic infected patients
CN111569010B (en) * 2020-05-06 2021-08-20 石家庄市第五医院 Traditional Chinese medicine composition and application thereof in preparation of medicine for treating neocoronary pneumonia

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