CN111569010B - Traditional Chinese medicine composition and application thereof in preparation of medicine for treating neocoronary pneumonia - Google Patents
Traditional Chinese medicine composition and application thereof in preparation of medicine for treating neocoronary pneumonia Download PDFInfo
- Publication number
- CN111569010B CN111569010B CN202010373198.3A CN202010373198A CN111569010B CN 111569010 B CN111569010 B CN 111569010B CN 202010373198 A CN202010373198 A CN 202010373198A CN 111569010 B CN111569010 B CN 111569010B
- Authority
- CN
- China
- Prior art keywords
- parts
- raw materials
- traditional chinese
- treating
- chinese medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003814 drug Substances 0.000 title claims abstract description 57
- 206010035664 Pneumonia Diseases 0.000 title claims abstract description 41
- 239000000203 mixture Substances 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 239000002994 raw material Substances 0.000 claims abstract description 33
- 241001598107 Imperata Species 0.000 claims abstract description 8
- 244000025254 Cannabis sativa Species 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 238000000605 extraction Methods 0.000 claims description 10
- 240000002505 Pogostemon cablin Species 0.000 claims description 9
- 235000011751 Pogostemon cablin Nutrition 0.000 claims description 9
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims description 9
- 240000004922 Vigna radiata Species 0.000 claims description 9
- 235000010721 Vigna radiata var radiata Nutrition 0.000 claims description 9
- 235000011469 Vigna radiata var sublobata Nutrition 0.000 claims description 9
- 241000037740 Coptis chinensis Species 0.000 claims description 8
- 241000245665 Taraxacum Species 0.000 claims description 8
- 241000157352 Uncaria Species 0.000 claims description 8
- 229910052602 gypsum Inorganic materials 0.000 claims description 8
- 239000010440 gypsum Substances 0.000 claims description 8
- 241000906579 Actaea cimicifuga Species 0.000 claims description 6
- 241000334160 Isatis Species 0.000 claims description 6
- 238000005303 weighing Methods 0.000 claims description 3
- 240000007171 Imperata cylindrica Species 0.000 claims 1
- 206010037660 Pyrexia Diseases 0.000 abstract description 15
- 206010012735 Diarrhoea Diseases 0.000 abstract description 10
- 208000001528 Coronaviridae Infections Diseases 0.000 abstract description 9
- 206010011224 Cough Diseases 0.000 abstract description 8
- 208000000059 Dyspnea Diseases 0.000 abstract description 7
- 206010013975 Dyspnoeas Diseases 0.000 abstract description 7
- 239000010231 banlangen Substances 0.000 abstract description 6
- 208000022531 anorexia Diseases 0.000 abstract description 4
- 206010061428 decreased appetite Diseases 0.000 abstract description 4
- 208000006673 asthma Diseases 0.000 abstract description 3
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 abstract description 3
- 229940126680 traditional chinese medicines Drugs 0.000 abstract description 3
- 241001529821 Agastache Species 0.000 abstract description 2
- 229940104299 cimicifugae rhizoma Drugs 0.000 abstract description 2
- 210000000582 semen Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 20
- 208000024891 symptom Diseases 0.000 description 17
- 241000711573 Coronaviridae Species 0.000 description 14
- 210000004072 lung Anatomy 0.000 description 11
- 229940079593 drug Drugs 0.000 description 10
- 210000002784 stomach Anatomy 0.000 description 10
- 230000001717 pathogenic effect Effects 0.000 description 8
- 231100000419 toxicity Toxicity 0.000 description 8
- 230000001988 toxicity Effects 0.000 description 8
- 235000009508 confectionery Nutrition 0.000 description 6
- 208000015181 infectious disease Diseases 0.000 description 6
- 241000700605 Viruses Species 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 210000000952 spleen Anatomy 0.000 description 5
- 239000003053 toxin Substances 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000003384 imaging method Methods 0.000 description 4
- 208000011580 syndromic disease Diseases 0.000 description 4
- 230000008673 vomiting Effects 0.000 description 4
- 206010068319 Oropharyngeal pain Diseases 0.000 description 3
- 201000007100 Pharyngitis Diseases 0.000 description 3
- 206010047700 Vomiting Diseases 0.000 description 3
- 230000036760 body temperature Effects 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 210000002429 large intestine Anatomy 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 230000027939 micturition Effects 0.000 description 3
- 208000030194 mouth disease Diseases 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 231100000765 toxin Toxicity 0.000 description 3
- 206010008479 Chest Pain Diseases 0.000 description 2
- 241000218202 Coptis Species 0.000 description 2
- 235000002991 Coptis groenlandica Nutrition 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 2
- 208000006083 Hypokinesia Diseases 0.000 description 2
- 206010039101 Rhinorrhoea Diseases 0.000 description 2
- 239000003443 antiviral agent Substances 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 208000017574 dry cough Diseases 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 206010016256 fatigue Diseases 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 230000002458 infectious effect Effects 0.000 description 2
- 208000010753 nasal discharge Diseases 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 208000013220 shortness of breath Diseases 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 208000010444 Acidosis Diseases 0.000 description 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 206010002869 Anxiety symptoms Diseases 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 208000015220 Febrile disease Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010027417 Metabolic acidosis Diseases 0.000 description 1
- 208000034486 Multi-organ failure Diseases 0.000 description 1
- 208000010718 Multiple Organ Failure Diseases 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 206010028748 Nasal obstruction Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 206010040070 Septic Shock Diseases 0.000 description 1
- 201000003176 Severe Acute Respiratory Syndrome Diseases 0.000 description 1
- 208000032140 Sleepiness Diseases 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 240000001949 Taraxacum officinale Species 0.000 description 1
- 241000157373 Uncaria rhynchophylla Species 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 201000009267 bronchiectasis Diseases 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 208000024829 digestive system symptom Diseases 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000021760 high fever Diseases 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 208000018875 hypoxemia Diseases 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 208000030208 low-grade fever Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 210000003300 oropharynx Anatomy 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 235000021251 pulses Nutrition 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 230000036303 septic shock Effects 0.000 description 1
- 230000037321 sleepiness Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 210000004916 vomit Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition and application thereof in preparation of a medicine for treating neocoronary pneumonia. The composition comprises the following raw materials: gypsum Fibrosum, radix Isatidis, cimicifugae rhizoma, herba Agastaches, herba Taraxaci, Coptidis rhizoma, lalang grass rhizome, cortex moutan, semen Phaseoli Radiati and ramulus Uncariae cum uncis. The composition is mainly used for treating fever, cough, asthma, anorexia, dyspnea, diarrhea, etc. caused by new coronavirus infection, and can be used for effectively treating new coronary pneumonia caused by new coronavirus infection.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition and application thereof in preparation of a medicine for treating neocoronary pneumonia.
Background
The novel coronavirus (hereinafter referred to as new coronavirus) can be transmitted by respiratory droplets and in close contact, has strong transmission capability and is difficult to prevent. Medical care personnel are exposed in an environment with high virus content for a long time and can be infected by a large number of patients and asymptomatic virus carriers if the medical care personnel are in contact with the virus carriers. For the elderly and people with underlying diseases, immunity is generally low and there is also a risk of infection after exposure to viruses. The latent period after infection of new corona virus can be as long as 14 days, asymptomatic infected persons in the latent period are also infectious, and data show that one new corona infected person can infect several to tens of persons. After the infection of new coronavirus, the clinical manifestations are fever, diarrhea, cough, anorexia, palpitation and shortness of breath, and the severe patients can cause pneumonia, severe acute respiratory syndrome, renal failure and even death.
The novel coronavirus pneumonia (hereinafter referred to as new coronary pneumonia) is different from common pneumonia, the common pneumonia is less infectious, generally caused by incomplete treatment after external pathogenic factors are infected, and generally diagnosed as wind-heat invading lung or fire-toxin accumulating lung in the field of traditional Chinese medicine. The new coronary pneumonia belongs to the category of 'grumpy' in the traditional Chinese medicine, mainly attacks the lung meridian of hand taiyin and the large intestine meridian of hand yangming, causes the lung to lose the function of dispersing and descending, and dampness blocks the middle energizer, has the basic pathogenesis characteristics of 'dampness, toxicity, stasis and block', mainly causes 'dampness', easily blocks qi activity, attacks the middle energizer spleen and stomach, has symptoms of digestive system symptoms of the spleen and stomach, is encumbered by dampness pathogen, has a lingering course of disease, has early clinical manifestations of poor appetite, sleepiness and weakness, head covering and thick and greasy fur, and has similar symptoms no matter whether men or women are old or young. The clinical manifestations of the middle stage are no fever or alternating chills and fever with chest distress and shortness of breath, cough, dyspnea, mouth opening and shoulder raising during respiration, red tongue with yellow greasy or yellow dry coating, little or yellow phlegm, and smooth and rapid pulse. In terms of treatment, common pneumonia mostly has high fever as a main symptom, so the used traditional Chinese medicines mostly have large dose of heat-clearing and toxicity-removing medicines as main medicines. The new coronary pneumonia is mainly low-grade fever, the lung fails to disperse and descend, and belongs to deficiency syndrome, so the new coronary pneumonia is not suitable for large-dose cold and cool medicines. Therefore, the traditional Chinese medicine treatment scheme for common pneumonia is not suitable for treating the new coronary pneumonia.
The hand-foot-mouth disease also belongs to the category of 'grume' in the traditional Chinese medicine, has similar parts with the clinical manifestations of the new crown pneumonia, but the causes of the hand-foot-mouth disease are related to internal blood heat, external wind heat, cold, summer heat and damp qi, or seasonal pathogenic epidemic toxin, or accumulated heat of internal organs, pathogenic toxin stagnation, qi stagnation, water-damp internal stagnation, body vital qi and toxin conflict, and external penetrating muscle surface, so that hands, feet and oropharynx parts give off sparse herpes, and the causes and the clinical manifestations are different from the causes and the clinical manifestations of the new crown pneumonia, therefore, the traditional Chinese medicine treatment scheme of the hand-foot-mouth disease is not suitable for treating the new crown pneumonia.
However, no effective antiviral drug aiming at the new coronavirus is found at present, the treatment mainly comprises isolation and symptomatic support, an effective treatment method is not available, and the condition that symptoms do not disappear in time or the patients recover from yang can also appear in part of patients.
Disclosure of Invention
Aiming at the technical problems that no effective antiviral drug aiming at the new coronavirus is found and no effective treatment method is available at present, the invention provides a traditional Chinese medicine composition.
The invention also provides application of the composition in preparing a medicine for treating neocoronary pneumonia.
In order to achieve the purpose of the invention, the embodiment of the invention adopts the following technical scheme:
a traditional Chinese medicine composition comprises the following raw materials in parts by weight: 8-12 parts of gypsum, 8-12 parts of isatis root, 10-14 parts of cimicifuga foetida, 8-10 parts of patchouli, 8-10 parts of dandelion, 7-11 parts of coptis chinensis, 10-14 parts of cogongrass rhizome, 8-12 parts of moutan bark, 8-12 parts of mung bean and 10-14 parts of uncaria.
The traditional Chinese medicine composition provided by the invention comprises the following components:
gypsum Fibrosum, which is sweet and pungent in flavor and cold in nature, enters lung and stomach meridians, is good in ventilation and divides heat evil, can treat fever symptom after novel coronavirus infection, achieves the early stage cutoff effect of 'penetrating heat outside', and is used as a monarch drug in the Chinese medicinal composition.
Radix Isatidis is bitter in taste and cold in nature, and has effects of entering heart and stomach meridians, clearing heat and removing toxicity, cooling blood and relieving sore throat, and has the effect of removing toxicity, relieving sore throat and resolving hard mass.
Cimicifugae rhizoma is pungent, slightly sweet and cold in nature, enters lung, spleen, stomach and large intestine channels, has the functions of relieving exterior syndrome, promoting eruption, clearing heat and removing toxicity, lifting yang qi, ascending and dispersing property, relieving exterior syndrome and allaying fever, and has the effect of clearing heat and removing toxicity.
Patchouli is pungent in taste and slightly warm in nature, has the effects of invigorating spleen, stomach and lung channels, regulating the middle warmer, removing dirt, eliminating dampness, eliminating turbid pathogen, regulating the middle warmer and stopping vomiting, is used for treating turbid pathogen, fever and lassitude, chest distress, abdominal pain and vomiting and diarrhea, and can effectively improve symptoms of hypodynamia or watery nasal discharge, diarrhea and the like which are clinically shown after the novel coronavirus infection.
The dandelion is bitter and sweet in taste and cold in nature, enters liver and stomach meridians, has the effects of clearing heat and removing toxicity, resolving carbuncle and dissipating stagnation, and removing dampness and treating stranguria, has the effect of relieving diarrhea besides the effect of clearing heat and removing toxicity, and can improve fever and diarrhea symptoms after novel coronavirus infection.
Coptis root, rhizoma Coptidis, being bitter in taste, cold in nature, has the effects of clearing heat, drying dampness, purging fire and removing toxicity, is good at clearing damp-heat in the middle energizer, spleen and stomach and large intestine, and has significant curative effect on diarrhea of patients infected by the novel coronavirus.
The cogongrass rhizome is sweet in taste and cold in nature, has the effects of cooling blood, clearing heat and promoting urination, treating asthenic disease caused by overstrain, tonifying middle-jiao and Qi, clearing away the heat of the lung and the stomach, reducing the adverse flow of pathogenic fire, clearing away the heat of the stomach to stop vomiting, clearing away the heat of the lung to relieve cough, and can assist the main drug in clearing heat and relieve the symptoms of weakness caused by deficiency of vital qi after the novel coronavirus infection.
The cortex moutan is bitter and pungent in taste and slightly cold in nature, enters lung meridian, enters blood system, and is good in clearing yin latent heat, is used for treating pathogenic yin latent heat in later stage of epidemic febrile disease, and is hot and cool early at night, so that the cortex moutan can be applied to middle-low fever in course of disease of novel severe patients with later stage of coronavirus qi consumption and yin impairment, and even has no obvious fever symptom.
The mung beans are sweet in taste and cool in nature, can clear heat and relieve summer heat, relieve restlessness and quench thirst, promote urination, have certain effects of inducing diuresis and relieving swelling, and can be used for treating difficult urination, edema and the like.
Uncaria rhynchophylla is sweet in flavor, cold in nature, capable of extinguishing wind and relieving convulsion, and capable of clearing heat and calming liver. In addition, patients infected by the novel coronavirus often have anxiety fear, and the application of uncaria can also relieve the anxiety symptoms of the patients infected by the novel coronavirus.
The whole prescription takes gypsum as the monarch drug, radix isatidis, rhizoma cimicifugae and patchouli as ministerial drugs, and dandelion, coptis chinensis, moutan bark, lalang grass rhizome, mung bean and uncaria as adjuvant drugs. Gypsum and coptis are bitter and cold products, the cold can clear away heat evil, the bitter can purge heart and relieve stuffiness, the combination of the two medicines can clear away heat, ensure qi smooth and relieve stuffiness. Ramulus Uncariae cum uncis and cortex moutan are used together to clear heat, cool blood, calm liver and extinguish wind, and are used for treating headache, dizziness and dysphoria due to hyperactivity of liver-yang caused by excessive heat and wind after infection. Herba Agastaches and radix Isatidis can be combined with rhizoma cimicifugae and radix Isatidis to achieve effects of eliminating dampness with aromatics, regulating the middle warmer, relieving vomit, promoting eruption, clearing away heat and toxic materials, relieving sore throat, and resolving hard mass. The whole prescription can be used for treating symptoms such as fever, cough, asthma, anorexia, dyspnea, diarrhea and the like caused by new coronavirus infection and other heat-toxin fire syndromes, and can effectively treat new coronary pneumonia caused by new coronavirus infection. Compared with the similar medicines, the traditional Chinese medicine composition has relatively small toxic and side effects and is safe to use.
Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 9-11 parts of gypsum, 9-11 parts of isatis root, 11-13 parts of cimicifuga foetida, 8.5-9.5 parts of patchouli, 8.5-9.5 parts of dandelion, 8-10 parts of coptis chinensis, 11-13 parts of lalang grass rhizome, 9-11 parts of moutan bark, 9-11 parts of mung bean and 11-13 parts of uncaria.
Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10 parts of gypsum, 10 parts of isatis root, 12 parts of cimicifuga foetida, 9 parts of patchouli, 9 parts of dandelion, 9 parts of coptis chinensis, 12 parts of lalang grass rhizome, 10 parts of moutan bark, 10 parts of mung bean and 12 parts of uncaria.
In the practical use of the traditional Chinese medicine, 1g of the traditional Chinese medicine is used as each dose, and 1-2 doses are used every day according to the state of illness.
The embodiment of the invention also provides application of the traditional Chinese medicine composition in preparing a medicine for treating neocoronary pneumonia. The composition can effectively improve symptoms such as fever, cough, asthma, anorexia, dyspnea, diarrhea and the like caused by new coronary virus infection, has good effect through clinical verification, and can be used for preparing a medicament for treating new coronary pneumonia.
The embodiment of the invention also provides a medicine for treating neocoronary pneumonia, which comprises the composition.
Preferably, the preparation method of the medicament comprises the following steps: weighing the raw materials according to the raw material proportion in the traditional Chinese medicine composition, decocting and extracting the raw materials with water, collecting the obtained extracting solution, and concentrating. The obtained concentrated solution can be further treated by sterilization and drying according to actual needs.
The preparation method is simple to operate and is suitable for small-batch production and large-production-scale production. The composition can be extracted and concentrated by the preparation method, and has reduced dosage and convenient administration. The obtained concentrated solution can be further made into oral dosage forms such as oral liquid, tablet, granule, capsule, powder, etc.
Preferably, the water decoction extraction method is to decoct the raw materials with water which is 6-8 times of the weight of the raw materials for 2-3 times, and each time lasts for 1-1.5 hours.
Preferably, the water decoction extraction method comprises the steps of firstly decocting the raw materials for 1.5 hours by using water with the weight 8 times of that of the raw materials, and then decocting the raw materials for 1 hour by using water with the weight 6 times of that of the raw materials.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Examples
The embodiment of the invention provides a traditional Chinese medicine composition, and in each embodiment, raw materials in each dose are shown in table 1 (unit: g).
TABLE 1 raw material composition of the Chinese medicinal composition in each example
| Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | |
| Gypsum Fibrosum | 10 | 9 | 11 | 8 | 12 |
| Radix Isatidis | 10 | 9 | 11 | 8 | 12 |
| Cimicifugae foetidae | 12 | 11 | 13 | 10 | 14 |
| Pogostemon cablin | 9 | 8.5 | 9.5 | 8 | 10 |
| Dandelion | 9 | 8.5 | 9.5 | 8 | 10 |
| Coptis chinensis | 9 | 8 | 10 | 7 | 11 |
| Rhizoma Imperatae | 12 | 11 | 13 | 10 | 14 |
| Cortex moutan | 10 | 9 | 11 | 8 | 12 |
| Mung bean | 10 | 9 | 11 | 8 | 12 |
| Ramulus Uncariae cum uncis | 12 | 11 | 13 | 10 | 14 |
The embodiment of the invention also provides a medicine for treating neocoronal pneumonia, which is prepared by weighing the raw materials according to the formula of each traditional Chinese medicine composition in the embodiment 1-5, decocting the raw materials with water which is 6-8 times of the weight of the raw materials for 2-3 times, and decocting for 1-1.5 hours each time, collecting the obtained extract, concentrating and sterilizing. The raw material composition of each agent and the parameter conditions in the preparation method in each example are shown in table 2.
TABLE 2 raw material composition and preparation parameters for the examples
| Example 6 | Example 7 | Example 8 | Example 9 | Example 10 | |
| Composition of raw materials | Same as example 1 | Same as example 2 | Same as example 3 | Same as example 4 | Same as example 5 |
| The water adding amount for the first extraction | 824g | 752g | 896g | 680g | 820g |
| Time of first extraction | 1.5h | 1h | 1.5h | 1h | 1.5h |
| The water adding amount for the second extraction | 618g | 564g | 672g | 680g | 750g |
| Second extraction time | 1h | 1h | 1.5h | 1h | 1h |
| Adding water for the third extraction | / | 564g | / | / | 750g |
| Time of the third extraction | / | 1h | / | / | 1h |
| Relative density after concentration | 1.08 | 1.05 | 1.07 | 1.10 | 1.06 |
Effect example 1
The effect example provides the use effect of the medicine for treating the new coronary pneumonia.
1. The source of the cases is:
28 patients (including 7 overseas input cases) with new coronary pneumonia are treated and treated by the fifth hospital in Shijiazhuan city, wherein the patients have the minimum age of 4 years, the maximum age of 72 years and the average age of 42 years, and have symptoms for 3-10 days before treatment. The new coronavirus of each patient is detected to be positive, the total number of white blood cells is mostly not increased, the main clinical symptoms are mainly manifested by fever, dry cough and hypodynamia, and a few patients are accompanied by symptoms such as nasal obstruction, watery nasal discharge, pharyngalgia, myalgia, diarrhea and the like; severe patients often have dyspnea and/or hypoxemia after one week of onset, and severe patients can rapidly progress to acute respiratory distress syndrome, septic shock, metabolic acidosis difficult to correct, coagulation dysfunction, multiple organ failure and the like; mild patients only manifest low fever, slight asthenia, etc., and no manifestations of pulmonary inflammation.
2. The treatment method comprises the following steps:
each person takes one dose of the medicine for treating the new coronary pneumonia, which is provided by the embodiment 6 of the invention, every day, and the medicine is treated according to the methods of ' ten, treatment ' (one) general treatment ' and ' three) treatment for severe and critical cases ' in a novel diagnosis and treatment scheme (trial seventh edition) of coronavirus pneumonia, which is published by the State health and wellness Commission.
3. The therapeutic effect judgment standard is as follows:
and (3) curing: the body temperature returns to normal, the nucleic acid detection of the new coronavirus turns negative, and the pneumonia is not shown in the imaging;
the method has the following advantages: the body temperature returns to normal, and the imaging shows slight pneumonia;
and (4) invalidation: the clinical symptoms are not obviously improved, and the imaging pneumonia is shown.
4. The treatment effect is as follows:
the patients in 28 cases with confirmed diagnosis are all cured, and the cure rate is 100 percent. After healing, follow-up until now, no yang recovery.
5. Typical cases are:
patient fangqi, male, 67 years old, symptoms: dry cough, low fever, lassitude, bronchiectasis, etc. After the medicine for treating the new coronary pneumonia provided by the embodiment 6 of the invention is taken every day, the body temperature is reduced to be normal after 6 days, and the symptoms related to the new coronary pneumonia are obviously weakened; after the application for 5 days, the virus nucleic acid detection is negative, and no new coronary pneumonia is shown in the chest imaging.
The results show that the traditional Chinese medicine composition provided by the invention can effectively treat the new coronavirus infection.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents or improvements made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (8)
1. The traditional Chinese medicine composition is characterized by comprising the following raw materials in parts by weight: 8-12 parts of gypsum, 8-12 parts of isatis root, 10-14 parts of cimicifuga foetida, 8-10 parts of patchouli, 8-10 parts of dandelion, 7-11 parts of coptis chinensis, 10-14 parts of cogongrass rhizome, 8-12 parts of moutan bark, 8-12 parts of mung bean and 10-14 parts of uncaria.
2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight: 9-11 parts of gypsum, 9-11 parts of isatis root, 11-13 parts of cimicifuga foetida, 8.5-9.5 parts of patchouli, 8.5-9.5 parts of dandelion, 8-10 parts of coptis chinensis, 11-13 parts of lalang grass rhizome, 9-11 parts of moutan bark, 9-11 parts of mung bean and 11-13 parts of uncaria.
3. The traditional Chinese medicine composition according to claim 2, which is prepared from the following raw materials in parts by weight: 10 parts of gypsum, 10 parts of isatis root, 12 parts of cimicifuga foetida, 9 parts of patchouli, 9 parts of dandelion, 9 parts of coptis chinensis, 12 parts of lalang grass rhizome, 10 parts of moutan bark, 10 parts of mung bean and 12 parts of uncaria.
4. Use of the Chinese medicinal composition of any one of claims 1 to 3 in the preparation of a medicament for treating neocoronary pneumonia.
5. A medicine for treating neocoronary pneumonia, which is characterized by comprising the traditional Chinese medicine composition of any one of claims 1-3.
6. The medicine for treating the neocoronary pneumonia according to claim 5, wherein the preparation method of the medicine comprises the following steps: weighing the raw materials according to the raw material proportion in the traditional Chinese medicine composition, decocting and extracting the raw materials with water, collecting the obtained extracting solution, and concentrating.
7. The medicine for treating neocoronary pneumonia according to claim 6, wherein the water decoction extraction method is to decoct the raw materials with water 6-8 times of the weight of the raw materials for 2-3 times, and each time lasts for 1-1.5 hours.
8. The medicine for treating neocoronary pneumonia according to claim 7, wherein the water decoction extraction method comprises decocting the raw materials for 1.5 hours with water which is 8 times of the weight of the raw materials, and then decocting the raw materials for 1 hour with water which is 6 times of the weight of the raw materials.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010373198.3A CN111569010B (en) | 2020-05-06 | 2020-05-06 | Traditional Chinese medicine composition and application thereof in preparation of medicine for treating neocoronary pneumonia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010373198.3A CN111569010B (en) | 2020-05-06 | 2020-05-06 | Traditional Chinese medicine composition and application thereof in preparation of medicine for treating neocoronary pneumonia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111569010A CN111569010A (en) | 2020-08-25 |
| CN111569010B true CN111569010B (en) | 2021-08-20 |
Family
ID=72118595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010373198.3A Active CN111569010B (en) | 2020-05-06 | 2020-05-06 | Traditional Chinese medicine composition and application thereof in preparation of medicine for treating neocoronary pneumonia |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111569010B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022043738A1 (en) * | 2020-08-29 | 2022-03-03 | Portillo Rosado Rosa Maria | Pharmaceutical composition containing a surfactant and natural plant extracts for preventing and treating coronavirus |
| CN114224948A (en) * | 2021-12-28 | 2022-03-25 | 威科检测集团有限公司 | A Chinese medicinal composition for treating new coronavirus, and its preparation method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111097021A (en) * | 2020-02-17 | 2020-05-05 | 曹利平 | Traditional Chinese medicine composition for treating mild and suspected new coronary pneumonia and acute respiratory infection |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0405545D0 (en) * | 2004-03-12 | 2004-04-21 | Univ Manchester | Antimicrobial composition |
-
2020
- 2020-05-06 CN CN202010373198.3A patent/CN111569010B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111097021A (en) * | 2020-02-17 | 2020-05-05 | 曹利平 | Traditional Chinese medicine composition for treating mild and suspected new coronary pneumonia and acute respiratory infection |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111569010A (en) | 2020-08-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111671880B (en) | Traditional Chinese medicine preparation for treating fever caused by coronavirus pneumonia | |
| CN111671867B (en) | Novel traditional Chinese medicine composition for treating mild coronary virus pneumonia cough | |
| CN111388582B (en) | Traditional Chinese medicine composition for treating novel coronavirus pneumonia and application of preparation thereof | |
| CN112353855A (en) | Application of traditional Chinese medicine composition in preparation of medicine for adjuvant therapy of novel coronavirus pneumonia | |
| CN111569035B (en) | Traditional Chinese medicine composition and application thereof in preparation of medicine for treating new coronary pneumonia, especially asymptomatic infected patients | |
| CN111569010B (en) | Traditional Chinese medicine composition and application thereof in preparation of medicine for treating neocoronary pneumonia | |
| CN113577140A (en) | Traditional Chinese medicine composition for treating neocoronary pneumonia and preparation method and application thereof | |
| CN116139237B (en) | A Chinese medicinal composition for preventing and treating respiratory tract infection caused by coronavirus, and its application | |
| CN102631527A (en) | Chinese patent medicine for treating acute urticaria | |
| CN102139051B (en) | Application of soft capsule capable of clearing heat and eliminating toxin in preparation of medicament for treating viral pneumonia | |
| CN102380075B (en) | Chinese medicine for treating child respiratory system infection and inflammation | |
| CN104547048A (en) | Chinese herbal medicine compound preparation for preventing and treating infantile hand-foot-mouth disease and preparation method thereof | |
| CN111671868B (en) | Novel traditional Chinese medicine composition for treating mild symptoms, namely coronavirus pneumonia and insomnia | |
| CN105327182A (en) | Medicine for treating child pertussis and preparation method thereof | |
| CN104096053A (en) | Medicine composition for treating infantile pneumonia | |
| CN105194165B (en) | Traditional Chinese medicine used for treating infection of urinary system and preparation method thereof | |
| CN115998824B (en) | Traditional Chinese medicine composition for clearing damp and detoxicating, and preparation method and application thereof | |
| CN102631648A (en) | Chinese patent medicine for treating acute urticaria | |
| CN105250435A (en) | Compound Chinese herbal medicine preparation for treating influenza and preparation method of compound Chinese herbal medicine preparation | |
| CN105250417A (en) | Pharmaceutical composition for treating diarrheic type irritable bowel syndrome and application thereof | |
| CN104667247A (en) | Traditional Chinese medicinal composition for treating cough and preparation method of traditional Chinese medicinal composition | |
| CN117482167A (en) | Traditional Chinese medicine composition for treating lung infection related to AIDS and traditional Chinese medicine preparation thereof | |
| CN102908594B (en) | Anti-influenza and anti-common-cold Chinese herbal compound prescription and preparation method and application thereof | |
| CN102552587A (en) | Traditional Chinese medicine used for treating viral encephalitis | |
| CN107823424A (en) | A kind of Chinese medicine composition for treating chronic pharyngitis and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |