CN104547048A - Chinese herbal medicine compound preparation for preventing and treating infantile hand-foot-mouth disease and preparation method thereof - Google Patents

Abstract

The invention relates to a Chinese herbal medicine compound preparation for preventing and treating the infantile hand-foot-mouth disease and a preparation method thereof and solves the technical problems of complex formula, unobvious curative effect and big side effects of an existing preparation. The Chinese herbal medicine compound preparation is prepared from the following ingredient raw materials: honeysuckle, forsythia suspense, stir-baked fructus arctii, dandelion, scutellaria baicalensis, saposhnicovia divaricata, the root of kudzu vine, folia perillae acutae, schizonepetaspike and artificial bezoar. The invention also provides the preparation method of the Chinese herbal medicine compound preparation for preventing and treating the infantile hand-foot-mouth disease. The preparation method can be used in the field of preparing the Chinese herbal medicine compound preparation for preventing and treating the infantile hand-foot-mouth disease.

Description

A kind ofly to prevent and compound Chinese medicinal preparation for the treatment of Hand-Food-Mouth Disease and preparation method thereof

Technical field

The present invention relates to field of traditional Chinese, is a kind of prevention and compound Chinese medicinal preparation for the treatment of Hand-Food-Mouth Disease and preparation method thereof specifically.

Background technology

Hand-Food-Mouth Disease is the self-limited disease occurring caused by a kind of viral infection that vesicle is feature with hands, foot or oral cavity.Hand-foot-mouth disease causes primarily of enterovirus, wherein with coxsackie virus A 16 and Enterovirus 71 (EV71) the most common.When enterovirus is invaded by the pharyngeal of infant or intestinal, cause local mucosa or lymph node propagation, virus enters blood by lymph node, cause viremia, each target organ of human body is entered again by blood circulation, there is corresponding clinical symptoms, show as maculopapule, the herpes at the positions such as hands, foot, oral cavity, buttocks, the mortality complication such as meningitis, encephalitis, brain stem encephalitis, neurogenic pulmonary edema, respiratory and circulatory failure can be caused individually, and in cell ceaselessly redox reaction also accelerate the pathological changes of cell and the reproduction process of virus.

The clinical Hand-Food-Mouth Disease patient accepting treatment for medical treatment presents trend occurred frequently always.This disease have development rapidly, feature that mortality rate is relatively high, all can fall ill throughout the year, spring, summer, autumn are the most popular.Morbidity crowd is mainly the infant of less than 6 years old, especially the highest with less than 3 years old age group sickness rate.Hand-Food-Mouth Disease infectiousness is strong, and its route of transmission has: the articles for daily use (towel, tooth cup, toy, milk tool, underwear, bedding etc.) that child is contacted; Throat secretions existing for infant self, saliva sexually transmitted disease (STD) poison as communication media by air, is caused and infects in the process contacted with infant; Drink in life, eat by the food of virus contamination and water etc., also can infect.This is sick, and once develop into serious symptom, can cause rapidly the mortality complication such as myocarditis, pulmonary edema, AME in a short time, various treatment measure is often invalid, usually dead in a short time.

Hand-foot-mouth disease is mainly in child's stage, causes harmful effect, even cause death to the growth of child, no matter is hand-foot-mouth disease patient, inapparent infection patient all can become the source of infection of hand-foot-mouth disease.With regard to present stage, the specific treatment means that primary disease is not still generally acknowledged at present, the formulation of overall clinical therapeutic scheme all with the concrete change of illness state of infant for reference frame, carry out general treatment, Drug therapy and specific aim treatment for diseases etc.At present, western medicine Hand-Food-Mouth Disease there is no specially good effect measure, mainly anti symptom treatment, takes vitamin B, C, antiviral drugs (acyclovir, interferon etc.) and antipyretic-antalgic agent etc.The side effect of doctor trained in Western medicine Systemic administration is large, and medicine causes certain damage to Liver and kidney, and curative effect is not satisfactory.

The traditional Chinese medical science thinks that the cause of disease of hand-foot-mouth disease is diseases caused by exogenous pathogenic factor seasonal pathogen epidemic disease poison, and internal injury damp-heat accumulation, heart-fire is flourishing, and sick position is dirty at lung, spleen, the heart three.At the commitment of hand-foot-mouth disease, disease is based on excess syndrome: the exopathogen such as ailment said due to cold or exposure, pathogenic heat invasion and attack lung is defended, and healthy energy is resisted with it, and struggle is violent.And at the middle and late stage of disease, be then many with syndrome of intermingled deficiency and excess.Damp and hot, the deficiency of YIN etc. is demonstrate,proved element and also plays an important role in the pathogenesis evolution of this disease.Therefore, the method for the treatment of of heat clearing away, removing dampness and YIN nourishing, yin nourishing and square medicine are the important measures for the treatment of hand-foot-mouth disease.For domestic report in nearly 5 years was that the case of main treatment Hand-Food-Mouth Disease is analyzed with Chinese medicine, a lot of doctor is with heat clearing away, removing toxic substances, damp eliminating is main principle, the Traditional Chinese medicine historical preparation adopted mostly is adult medication, such as: SHUANGHUANGLIAN ZHUSHEYE (Flos Lonicerae baikal skullcap root, forsythia fruit), potasium dehydroandrographolisuccinate succinate injection, the Chinese patent medicines such as QINGKAILING electuary (cholic acid Concha Margaritifera Hyodeoxycholic Acid Fructus Gardeniae Cornu Bovis seu Bubali Radix Isatidis xanthosine Flos Lonicerae), and daochi powder (Radix Rehmanniae, Caulis Akebiae, the Radix Glycyrrhizae tip), GEGEN QINLIAN TANG (Radix Puerariae, Radix Scutellariae, Rhizoma Coptidis, Radix Glycyrrhizae Preparata), XIEHUANGSAN (Radix agastaches, Fructus Gardeniae core, Gypsum Fibrosum, Radix Glycyrrhizae, Radix Saposhnikoviae) etc. traditional prescription and plus-minus side thereof, though can certain curative effect be reached clinically, but can infantile diarrhea be caused, liver function injury, the untoward reaction such as gastrointestinal upset.Childhood development is not yet ripe, and internal organs are tender, and also comparatively normal adult human is many to use the untoward reaction caused by adult medication, or even more serious.

Summary of the invention

Of the present invention with regard to the technical problem that existing pharmaceutical formulation is more complicated in order to solve, curative effect is remarkable, side effect is large, a kind of formula is reasonable, evident in efficacy, side effect is less prevention compound Chinese medicinal preparation for the treatment of Hand-Food-Mouth Disease and preparation method thereof are provided.

For this reason; the present invention prevents and the compound Chinese medicinal preparation for the treatment of Hand-Food-Mouth Disease is made up of following component materials: Flos Lonicerae, Fructus Forsythiae, Fructus Arctii (stir-fry), Herba Taraxaci, Radix Scutellariae, Radix Saposhnikoviae, Radix Puerariae, Folium Perillae, Herba Schizonepetae, artificial Calculus Bovis, and the weight proportion of each material composition is: Flos Lonicerae 50-70 gram, Fructus Forsythiae 40-60 gram, Fructus Arctii (stir-fry) 40-60 gram, Herba Taraxaci 50-70 gram, Radix Scutellariae 50-70 gram, Radix Saposhnikoviae 30-40 gram, Folium Perillae 20-40 gram, Herba Schizonepetae 10-20 gram, Radix Puerariae 20-40 gram, artificial Calculus Bovis 0.1-0.5 gram.

Preferably, to prevent and the compound Chinese medicinal preparation for the treatment of Hand-Food-Mouth Disease is made up of following component materials: Flos Lonicerae 60g, Fructus Forsythiae 52g, Fructus Arctii (stir-fry) 50g, Herba Taraxaci 60g, Radix Scutellariae 60g, Radix Saposhnikoviae 30g, Folium Perillae 30g, Herba Schizonepetae 20g, Radix Puerariae 30g, artificial Calculus Bovis 0.2g.

The present invention provides a kind of simultaneously and prevents and treat the preparation method of the compound Chinese medicinal preparation of Hand-Food-Mouth Disease, and its step is as follows: (1) takes Chinese crude drug Fructus Forsythiae, Folium Perillae, Herba Schizonepetae after cleaning according to prescription, is mixed evenly; (2) Fructus Forsythiae after mixed in (1), Folium Perillae, Herba Schizonepetae are added the water of offer medicine material gross mass 6-10 times amount, extract volatile oil, the another device collection of the aqueous solution after distillation; (3) render in extraction pot by the Flos Lonicerae after mixed, Fructus Arctii (stir-frys), Herba Taraxaci, Radix Scutellariae, Radix Saposhnikoviae, Radix Puerariae, decoct with water, maintenance boiling 2.5 hours, extracting solution metre filter, proceeds in receiver; (4) the continuation heating that added water by residue in (3) is boiled and is carried, and keep boiling 1.5 hours, extracting solution metre filter, proceeds in receiver; (5) aqueous solution after (3) being distilled with filtrate in (4) and (2) are middle merges, and is concentrated into relative density >=1.02, controls steam pressure≤0.1MPa, vacuum-0.04 ~-0.08MPa, temperature 50 ~ 85 DEG C; (6) by the cold preservation 12 hours under-5 DEG C ~-3 DEG C conditions of the medicinal liquid after concentrated in (5); (7) by cold preservation medical filtration in (6), filtrate citric acid or 10%HCL adjust pH value to be 4.2 ~ 4.5; (8) by filtrate-5 ~-3 DEG C of stored under refrigeration of (7) herb liquid; (9) Agitation Tank and pipe-line system thereof are sterilized 30 minutes, control pressure 0.08 ~ 0.1MPa in tank, after temperature 110 ~ 120 DEG C, in tank, must not steam condensate (SC) be had; (10) filter heat is boiled 30 minutes; (11) (8) herb liquid is added in dense preparing tank, add supplementary material, add artificial Calculus Bovis 0.2g by each recipe quantity, 4 ‰ cyclamates and potassium sorbate 3 ‰, heated and boiled 30 minutes; In heating process, every 5 ~ 10 minutes circulation primary; Then be cooled to less than 80 DEG C, be filtered to rare Agitation Tank through coarse filter; Add volatile oil, mixing, adds water and is adjusted to each recipe quantity 1000ml, ebuillition of heated 20 minutes, in heating process, every 5 ~ 10 minutes circulation primary, cooling, to less than 30 DEG C, pH value 4.0 ~ 4.6, relative density >=1.02, must not be less than 5.0mg containing every 10mL containing chlorogenic acid; Head tank is filtered to again through accurate filter, ultimate filter; (12) heated and boiled such as pipeline, filling machine, syringe needle, after 30 minutes, are taken out and installed and adjust filling machine; (13) carry out disinfection by disinfectant again after clean for the equipment utensil inner surface directly contacting medicine; (14) open master control switch, bottle is swung in operating board, open conveying start button, then open host-initiated button and electromagnetic induction aluminium foil sealing machine main power, regulate loading amount, qualified rear startup spiral cover button, carries out fill; (15) bottle tightening bottle cap after fill is transported to electromagnetic induction aluminium foil sealing machine place through conveyer belt, seals.

In the present invention, the effect of each composition is expressed as follows.

Flos Lonicerae: fragrant, lightly seasoned, the micro-hardship of gas.Return lung, the heart, stomach warp.For common Chinese medicine, there is the function of heat-clearing and toxic substances removing, anti-inflammation, hepatic cholagogic, and enjoy the good reputation of " national treasure YIZHIHUA ".

Fructus Forsythiae: bitter in the mouth, cold nature.Return lung, the heart, small intestine meridian.Effect of tool heat-clearing and toxic substances removing, mass dissipating and swelling eliminating, cures mainly warm, the disease such as erysipelas, macule, carbuncle and ulcer toxic swelling, urine stranguria with urinary obstruction.

Herba Taraxaci: bitter in the mouth, sweet, cold in nature.Return liver, stomach warp.There is heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, effect of inducing diuresis for treating stranguria syndrome.

Fructus Arctii (stir-fry): acrid in the mouth, hardship, cold in nature.Attach to the lung and stomach meridians.Have expelling wind and cold pathogens, lung qi dispersing eliminates the phlegm, sore-throat relieving rash, effect of removing toxic substances and promoting subsidence of swelling.

Radix Scutellariae: bitter in the mouth, cold in nature.Return lung, the heart, stomach, liver and gall, large intestine channel, mainly contain the effect of heat clearing and damp drying, eliminating fire and detoxication, arresting bleeding and miscarriage prevention.

Radix Saposhnikoviae: acrid in the mouth, sweet, warm in nature.Return lung, spleen, liver, urinary bladder channel.The effect such as have the loose wind that induces sweat, removing dampness to relieve pain, expelling wind and relieving convulsion is treatment flu, headache, one of rheumatic arthritis and tetanic the most frequently used Chinese medicine.

Radix Puerariae: sweet in the mouth, pungent, cool in nature.Return spleen, stomach warp.There is expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid, the effect such as rash, raw positive antidiarrheal, be used for treatment fever caused by exogenous pathogens, have a headache, quench one's thirst, measles without adequate eruption, hematodiarrhoea, the disease such as to have loose bowels.

Folium Perillae: acrid in the mouth, warm in nature.Return lung, spleen channel.Folium Perillae has delivers the effect such as cold expelling, promoting the circulation of QI to alleviate the stagnation in middle-JIAO.

Herba Schizonepetae: slightly warm in nature, acrid in the mouth.Return liver, lung meridian.Being usually used in treatment flu, headache, measles etc., is a kind of dispelling wind to relieve the exterior syndrome Chinese medicine that tcm clinical practice is extremely conventional, by numerous doctor is praised highly.

Calculus Bovis: bitter in the mouth, cool in nature.GUIXIN, Liver Channel.The effects such as Calculus Bovis has spasmolytic, antitussive, eliminates the phlegm, antiinflammatory.The disease of occur together heat and the local inflammations such as acute pneumonia, bronchitis, influenza, Common Cold is commonly used.

Children's's oral liquid that induces sweat has effect of heat-clearing and toxic substances removing, mass dissipating and swelling eliminating with Flos Lonicerae compatibility Fructus Forsythiae and Calculus Bovis, be monarch drug in side.Fructus Arctii (stir-fry), Herba Schizonepetae, Radix Saposhnikoviae, Radix Scutellariae, Radix Puerariae, Folium Perillae and Herba Taraxaci heat-clearing and toxic substances removing, dispelling wind and heat pathogens, is ministerial drug altogether with monarch drug compatibility, strengthens effect of its heat-clearing and toxic substances removing, has again the merit of diffusing lung, relieving exterior syndrome, eliminating phlegm arresting convulsion simultaneously.Assistant is with Radix Saposhnikoviae and Radix Puerariae removing dampness to relieve pain, pathogenic fire reducing toxin expelling.The mutual coordinative role of each component above, makes this medical instrument have heat-clearing and toxic substances removing, removing dampness to relieve pain, mass dissipating and swelling eliminating effect.Make a general survey of full side, its formula feature is as follows: in the early stage, existing diseases caused by exogenous pathogenic factor seasonal pathogen, has again damp to be the performance of suffering to disease, side selects Flos Lonicerae, Fructus Forsythiae, be the merit of the loose heresy of its heat-clearing and toxic substances removing, dispelling wind, send again the use of Radix Saposhnikoviae, Radix Scutellariae removing dampness for regulating stomach, more strengthen the power of we's removing toxic substances, make exopathogen solution, evil poison goes, and wet being stranded is removed, then all cards are known and disappeared.Sick in crisis, damp and hotly lay equal stress on, evil poison is flourishing, and with Flos Lonicerae, Herba Taraxaci heat-clearing and toxic substances removing in side, Radix Scutellariae heat clearing and damp drying, Fructus Arctii removing toxic substances and promoting subsidence of swelling, Folium Perillae promoting the circulation of QI to alleviate the stagnation in middle-JIAO, all medicines share, and make pyretic toxicity obtain clearly, turbid damp must be changed, and disease can be removed.Sick to the later stage, not to the greatest extent, use Radix Puerariae to grow body and be healthy and strong, both removing summer-heat waste heats, help again healthy energy to recover to remaining heresy.Children's induce sweat oral liquid for treatment Hand-Food-Mouth Disease evident in efficacy.

The present invention selects traditional genuine traditional Chinese medicine to take orally, effectively can treat Hand-Food-Mouth Disease.The present invention, with Flos Lonicerae, Fructus Forsythiae, Herba Taraxaci compatibility, has clearing away heat and expelling pathogen in the exterior, the merit of mass dissipating and swelling eliminating; Fructus Arctii, Radix Puerariae, Radix Scutellariae, Radix Saposhnikoviae, Herba Schizonepetae, Calculus Bovis, strengthen effects for removing toxic heat, has again the merit of diffusing lung, relieving exterior syndrome simultaneously.The all medicines of full side match, and have the merit of heat-clearing and toxic substances removing, removing dampness to relieve pain, mass dissipating and swelling eliminating, have antibacterial, antiviral, antipyretic and strengthen the effect of immunity in children simultaneously, therefore are specially adapted to hand-foot-mouth disease infant.

Usage: oral, shakes up when taking.One to two year old 5ml, 2 times on the one; Three to five years old 5ml, 3 times on the one; Six to ten four years old one time 10ml, 2-3 time on the one; The course for the treatment of 3-5 days.Treatment the course for the treatment of: the course for the treatment of 3-5 days.

Therapeutic effect: Henan Xixia Mine county people's hospital department of pediatrics huge book battalion chief physician gives 90 routine Hand-Food-Mouth Disease infants and takes children's orally and to induce sweat oral medicine liquid treatment, can reach effective percentage 100% after the course for the treatment of.

Detailed description of the invention

Below in conjunction with embodiment, the invention will be further described.

Embodiment 1

Prevent and treat the compound Chinese medicinal preparation of Hand-Food-Mouth Disease, taking raw material (gram) by following proportioning: Flos Lonicerae 60; Fructus Forsythiae 52; Fructus Arctii (stir-fry) 50; Herba Taraxaci 60; Radix Scutellariae 60; Radix Saposhnikoviae 30; Folium Perillae 30; Herba Schizonepetae 20; Radix Puerariae 30; Artificial Calculus Bovis 0.2.

Prevent and treat the method for making of the compound Chinese medicinal preparation of Hand-Food-Mouth Disease, it comprises the following steps:

(1) take Chinese crude drug Fructus Forsythiae, Folium Perillae, Herba Schizonepetae after cleaning according to prescription, be mixed evenly;

(2) Fructus Forsythiae after mixed in (1), Folium Perillae, Herba Schizonepetae are added the water of offer medicine material gross mass 6 times amount, extract volatile oil, the another device collection of the aqueous solution after distillation;

(3) render in extraction pot by the Flos Lonicerae after mixed, Fructus Arctii (stir-frys), Herba Taraxaci, Radix Scutellariae, Radix Saposhnikoviae, Radix Puerariae, decoct with water, maintenance boiling 2.5 hours, extracting solution metre filter, proceeds in receiver;

(4) the continuation heating that added water by residue in (3) is boiled and is carried, and keep boiling 1.5 hours, extracting solution metre filter, proceeds in receiver;

(5) aqueous solution after (3) being distilled with filtrate in (4) and (2) are middle merges, and is concentrated into relative density >=1.02.Control steam pressure≤0.1MPa, vacuum-0.04MPa, temperature 50 C;

(6) by the cold preservation 12 hours under-5 DEG C of conditions of the medicinal liquid after concentrated in (5);

(7) by cold preservation medical filtration in (6), filtrate citric acid or 10%HCL adjust pH value to be 4.2;

(8) by filtrate-5 DEG C of stored under refrigeration of (7) herb liquid;

(9) Agitation Tank and pipe-line system thereof are sterilized 30 minutes, control pressure 0.08MPa in tank, after temperature 110 DEG C, in tank, must not steam condensate (SC) be had;

(10) filter heat is boiled 30 minutes;

(11) (8) herb liquid is added in dense preparing tank, add supplementary material, add artificial Calculus Bovis 0.2g by each recipe quantity, 4 ‰ cyclamates and potassium sorbate 3 ‰, heated and boiled 30 minutes; In heating process, every 5 minutes circulation primary.Then be cooled to less than 80 DEG C, be filtered to rare Agitation Tank through coarse filter; Add volatile oil, mixing, adds water and is adjusted to each recipe quantity 1000ml, ebuillition of heated 20 minutes, in heating process, and every 5 minutes circulation primary, cooling, to less than 30 DEG C, pH value 4.0, relative density >=1.02, must not be less than 5.0mg containing every 10mL containing chlorogenic acid; Head tank is filtered to again through accurate filter, ultimate filter;

(12) heated and boiled such as pipeline, filling machine, syringe needle, after 30 minutes, are taken out and installed and adjust filling machine;

(13) carry out disinfection by disinfectant again after clean for the equipment utensil inner surface directly contacting medicine;

(14) open master control switch, bottle is swung in operating board, open conveying start button, then open host-initiated button and electromagnetic induction aluminium foil sealing machine main power, regulate loading amount, qualified rear startup spiral cover button, carries out fill;

(15) bottle tightening bottle cap after fill is transported to electromagnetic induction aluminium foil sealing machine place through conveyer belt, seals.

Embodiment 2

Prevent and treat the compound Chinese medicinal preparation of Hand-Food-Mouth Disease, taking raw material (gram) by following proportioning: Flos Lonicerae 50; Fructus Forsythiae 60; Fructus Arctii (stir-fry) 40; Herba Taraxaci 70; Radix Scutellariae 50; Radix Saposhnikoviae 40; Folium Perillae 20; Herba Schizonepetae 20; Radix Puerariae 20; Artificial Calculus Bovis 0.5.

Fructus Forsythiae after mixed in (1), Folium Perillae, Herba Schizonepetae, with embodiment 1, wherein in step (2), are added the water of offerd medicine material gross mass 8 times amount by its preparation method.

Embodiment 3

Prevent and treat the compound Chinese medicinal preparation of Hand-Food-Mouth Disease, taking raw material (gram) by following proportioning: Flos Lonicerae 70; Fructus Forsythiae 40; Fructus Arctii (stir-fry) 60; Herba Taraxaci 50; Radix Scutellariae 70; Radix Saposhnikoviae 35; Folium Perillae 40; Herba Schizonepetae 10; Radix Puerariae 40; Artificial Calculus Bovis 0.1.

Fructus Forsythiae after mixed in (1), Folium Perillae, Herba Schizonepetae, with embodiment 1, wherein in step (2), are added the water of offerd medicine material gross mass 10 times amount by its preparation method.

Claims (3)

1. one kind is prevented and treats the compound Chinese medicinal preparation of Hand-Food-Mouth Disease; it is made up of following component materials: Flos Lonicerae, Fructus Forsythiae, Fructus Arctii (parched), Herba Taraxaci, Radix Scutellariae, Radix Saposhnikoviae, Radix Puerariae, Folium Perillae, Herba Schizonepetae, artificial Calculus Bovis, it is characterized in that the weight proportion of each material composition is: Flos Lonicerae 50-70 gram, Fructus Forsythiae 40-60 gram, Fructus Arctii (parched) 40-60 gram, Herba Taraxaci 50-70 gram, Radix Scutellariae 50-70 gram, Radix Saposhnikoviae 30-40 gram, Folium Perillae 20-40 gram, Herba Schizonepetae 10-20 gram, Radix Puerariae 20-40 gram, artificial Calculus Bovis 0.1-0.5 gram.

2. prevention according to claim 1 treat the compound Chinese medicinal preparation of Hand-Food-Mouth Disease, is characterized in that the weight proportion of each raw material composition is: Flos Lonicerae 60g, Fructus Forsythiae 52g, Fructus Arctii 50g, Herba Taraxaci 60g, Radix Scutellariae 60g, Radix Saposhnikoviae 30g, Folium Perillae 30g, Herba Schizonepetae 20g, Radix Puerariae 30g, artificial Calculus Bovis 0.2g.

3. prevent as claimed in claim 1 and treat the preparation method of the compound Chinese medicinal preparation of Hand-Food-Mouth Disease, it is characterized in that step is as follows:

(1) take Chinese crude drug Fructus Forsythiae, Folium Perillae, Herba Schizonepetae after cleaning according to prescription, be mixed evenly;

(2) Fructus Forsythiae after mixed in (1), Folium Perillae, Herba Schizonepetae are added the water of offer medicine material gross mass 6-10 times amount, extract volatile oil, the another device collection of the aqueous solution after distillation;

(3) render in extraction pot by the Flos Lonicerae after mixed, Fructus Arctii (parched), Herba Taraxaci, Radix Scutellariae, Radix Saposhnikoviae, Radix Puerariae, decoct with water, keep boiling 2.5 hours, extracting solution metre filter, proceeds in receiver;

(4) the continuation heating that added water by residue in (3) is boiled and is carried, and keep boiling 1.5 hours, extracting solution metre filter, proceeds in receiver;

(5) aqueous solution after (3) being distilled with filtrate in (4) and (2) are middle merges, and is concentrated into relative density >=1.02, controls steam pressure≤0.1MPa, vacuum-0.04 ~-0.08MPa, temperature 50 ~ 85 DEG C;

(6) by the cold preservation 12 hours under-5 DEG C ~-3 DEG C conditions of the medicinal liquid after concentrated in (5);

(7) by cold preservation medical filtration in (6), filtrate citric acid or 10%HCL adjust pH value to be 4.2 ~ 4.5;

(8) by filtrate-5 ~-3 DEG C of stored under refrigeration of (7) herb liquid;

(9) Agitation Tank and pipe-line system thereof are sterilized 30 minutes, control pressure 0.08 ~ 0.1MPa in tank, after temperature 110 ~ 120 DEG C, in tank, must not steam condensate (SC) be had;

(10) filter heat is boiled 30 minutes;

(11) (8) herb liquid is added in dense preparing tank, add supplementary material, add artificial Calculus Bovis 0.2g by each recipe quantity, 4 ‰ cyclamates and potassium sorbate 3 ‰, heated and boiled 30 minutes; In heating process, every 5 ~ 10 minutes circulation primary; Then be cooled to less than 80 DEG C, be filtered to rare Agitation Tank through coarse filter; Add volatile oil, mixing, adds water and is adjusted to each recipe quantity 1000ml, ebuillition of heated 20 minutes, in heating process, every 5 ~ 10 minutes circulation primary, cooling, to less than 30 DEG C, pH value 4.0 ~ 4.6, relative density >=1.02, must not be less than 5.0mg containing every 10mL containing chlorogenic acid; Head tank is filtered to again through accurate filter, ultimate filter;

(12) heated and boiled such as pipeline, filling machine, syringe needle, after 30 minutes, are taken out and installed and adjust filling machine;

(13) carry out disinfection by disinfectant again after clean for the equipment utensil inner surface directly contacting medicine;

(14) open master control switch, bottle is swung in operating board, open conveying start button, then open host-initiated button and electromagnetic induction aluminium foil sealing machine main power, regulate loading amount, qualified rear startup spiral cover button, carries out fill;

(15) bottle tightening bottle cap after fill is transported to electromagnetic induction aluminium foil sealing machine place through conveyer belt, seals.