CN101301396B - Medicament for treating oral ulcer of children and preparation thereof - Google Patents

Abstract

The invention discloses a medicine for treating children stomatocace and a method for preparing the same. The medicine is mainly prepared by the following components of the yellow-corktree bark, the dried rehmannia root, the figwort root, the honeysuckle, the fiveleaf akebia, the Chinese goldthread and the root-bark of tree peony according to a certain proportioning by weight. The medicine of the invention has the functions of resolving heat, removing toxins, diminishing inflammation, killing bacteria, cooling blood and promoting wound healing and is mainly used to treat the children stomatocace with fast effect and high cure rate.

Description

A kind of medicine of treating dental ulcer of infant and preparation method thereof

Technical field:

The present invention relates to a kind of medicine of treating dental ulcer of infant and preparation method thereof, belong to the field of Chinese medicines.

Background technology:

Dental ulcer of infant is one of common oral disease, and clinical is characteristic for the upright circular or oval shallow-layer aphtha of arc appears in oral mucosa or lip, the lingual frenum the tip of the tongue, bicker, and outbreak is often because of violent spontaneous pain curtain coating cry and scream influence feed and sleep.Western medical treatment is many to be alleviated oral ulcer or treats with local application, can't in time solve the recovery from illness and the recurrence of oral ulcer.

Summary of the invention:

So there is great demand in the Chinese medicine preparation that people better treat dental ulcer of infant to curative effect.Up to now, also there is not to find relevant relevant report of treating the Chinese medicine medicine of dental ulcer of infant.The inventor is through research repeatedly, and the repeated validation through animal and clinical trial, and having worked out finally has the oral medicinal herb of better healing dental ulcer of infant medicine, thereby has accomplished the present invention.

The object of the invention just provides a kind of a kind of Chinese medicine composition of more effectively treating dental ulcer of infant.

Another object of the present invention has provided the method for preparing of this Chinese medicine composition.

Medicament selection Cortex Phellodendri of the present invention, the Radix Rehmanniae, Radix Scrophulariae, Flos Lonicerae, Fructus Forsythiae, Caulis Akebiae, Fructus Gardeniae, Radix Sophorae Tonkinensis, Rhizoma Coptidis, Radix Scutellariae, Cortex Moutan, Gypsum Fibrosum, Radix Glycyrrhizae and plate basket root make up; Make various efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of dental ulcer of infant.Wherein selecting Cortex Phellodendri for use is because of Cortex Phellodendri, and nature and flavor are bitter, and are cold, go into kidney, urinary bladder channel.Heat clearing away, dampness, pathogenic fire purging, detoxifcation.Control hematodiarrhoea, have loose bowels, quench one's thirst, yellow cellulitis, nocturnal emission, stranguria with turbid discharge, hemorrhoid are had blood in stool, leucorrhea with red and white discharge, hectic fever due to YIN-deficiency consumptive fever, conjunctival congestion and swelling pain, aphtha of the mouth and tongue, sore swollen toxin.Select for use the Radix Rehmanniae to be because the Radix Rehmanniae has another name called Radix Rehmanniae, Radix Rehmanniae, nature and flavor are sweet, bitter, cold, go into the heart, liver, kidney.Nourishing YIN and benefiting blood, tonifying deficiency, warming the middle warmer and descending qi.Cure mainly fever due to yin deficiency, diabetes are spitted blood metrorrhagia, menoxenia, frequent fetal movement, scorching constipation, rheumatic arthritis, eczema, infectious hepatitis, urticaria, neurodermatitis.Radix Scrophulariae has another name called Radix Scrophulariae, black Radix Scrophulariae, black ginseng, and nature and flavor are sweet, bitter, salty, are slightly cold.Go into lung, stomach, kidney channel.The removing heat from blood YIN nourishing, eliminating fire and detoxication.Be used for consumption of YIN caused by febrile disease, the crimson tongue excessive thirst, maculae caused by violent heat pathogen, constipation is hindered in Tianjin, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.Flos Lonicerae has another name called Flos Lonicerae, and nature and flavor are sweet, and is cold, goes into lung, stomach warp.Heat clearing away, detoxifcation.Control the epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.Select for use Fructus Forsythiae to be because its nature and flavor are bitter, the heart, liver, gallbladder meridian are gone in cold.Heat clearing away, detoxifcation, eliminating stagnation, detumescence.Control warm, erysipelas, macule, the carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.Select for use Caulis Akebiae to be because its nature and flavor are bitter, the heart, small intestinal, urinary bladder channel are gone in cold.Pathogenic fire purging row water, promoting blood circulation.Control hot urination, stranguria with turbid discharge, edema, irritable feverish sensation in the chest, sore throat pharyngalgia, inflexible pain all over, women's amenorrhea, galactostasis.Fructus Gardeniae has another name called Yellow Fructus Gardeniae, Semen Pittospori Glabrati, bright red Cape jasmine, and nature and flavor are bitter, and is cold, goes into the heart, lung, tri-jiao channel.Fruit: pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.It is vexed to be used for calentura, the jaundice dark coloured urine, and blood strangury and dry pain, heat in blood is told nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.Root: eliminating fire and detoxication, clearing away heat-damp and promoting diuresis, cool the blood dissipate blood stasis.Be used for infectious hepatitis, traumatic injury, acute toothache.Select for use Radix Sophorae Tonkinensis to be because its nature and flavor are bitter, cold, attach to the lung and stomach meridians.Heat-clearing and toxic substances removing, sharp cigarette detumescence.Select for use Rhizoma Coptidis to be because its nature and flavor are bitter, cold, go into the heart, liver, stomach, large intestine channel.Pathogenic fire purging, dampness, detoxifcation, parasite killing.Row pyretic toxicity when controlling, typhoid fever, intenseness of heat is vexed, and feeling of fullness is contrary, bacillary dysentery, diarrhea of heat type stomachache, pulmonary tuberculosis is told, is defeated in battle, is equipped with down, quenches one's thirst, infantile malnutrition, ascariasis, pertussis, cough caused by the disorders of throat swells and ache, acute catarrhal conjunctivitis, aphtha, skin sore, eczema, the burning hot wound of soup.Select for use Radix Scutellariae to be because its nature and flavor are bitter, cold, go into the heart, lung, gallbladder, large intestine channel.The removing the relative excess fire, except that damp and hot, hemostasis.Antiabortive.Control the high fever excessive thirst, the cough due to lung-heat, damp-heat dysentery, jaundice, pyretic stranguria is told, is defeated in battle, collapses, is leaked, conjunctival congestion and swelling pain, frequent fetal movement, carbuncle furuncle.Cortex Moutan another name unpeeled CORTEX MOUTAN, wooden Radix Paeoniae, Luoyang flower, nature and flavor are cold in nature, bitter in the mouth, suffering.Clearing away heat and cooling blood, blood circulation promoting competent silt.Be used for maculae caused by violent heat pathogen, tell, be defeated in battle, have blood in stool, the hectic fever due to YIN-deficiency consumptive fever, the amenorrhea dysmenorrhea, carbuncle sore tumefacting virus falls and pounces on the pain of injury.Select for use Gypsum Fibrosum to be because its nature and flavor are arduous, cold, go into lung, stomach warp.Give birth to the expelling pathogenic factors from muscles heat that disappears, relieving restlessness is quenched the thirst.Control the calentura high fever and do not move back, vexed coma, delirium is gone mad, thirsty and dry pharynx, the lung-heat dyspnea with rapid respiration, the heatstroke spontaneous perspiration, the stomach-fire headache, toothache, hyperactivity of toxic heat is sent out the speckle dermexanthesis, aphtha of the mouth and tongue.Forge deposited promoting tissue regeneration and ulcer healing.The external treatment ulcer sores is burst and is not closed up the burning hot wound of soup.Select for use Radix Glycyrrhizae to be because its nature and flavor are sweet, flat, go into spleen, stomach, lung meridian.With middle emergency, lung moistening, detoxifcation, coordinating the actions of various ingredients in a prescription.Process usefulness, control weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain heating, pulmonary fistula cough, cardiopalmus, infantile convulsion; Give birth to usefulness, control laryngopharynx swelling and pain, peptic ulcer, ulcer sores is separated poison of drug and alimentary toxicosis.In order to reach better therapeutic, medicine of the present invention also makes up with Radix Isatidis.This is because the Radix Isatidis nature and flavor are bitter, and is cold, GUIXIN, stomach warp, heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.The heating, the head that are used for due to the hyperactivity of toxic heat are sick, throat tumor, the swollen sore of pain.

In order to obtain optimum curative effect, medicine of the present invention can also loose by adapted external used medicine BINGSHI on the basis of said medicine, and this is to have the smart heat poison that looses because BINGSHI looses, and removing heat from blood is held back the function of skin ulcer, and it both can be sensible, heat clearing away, pathogenic fire purging, but priming again reaches hole key skin thoroughly.The diffusing partner treatment dental ulcer of infant effect of BINGSHI is stronger, and curative effect is best, and BINGSHI looses and selects for use Borneolum Syntheticum, Borax, Indigo Naturalis, Realgar to prepare, and wherein selects for use Borneolum Syntheticum to be because nature and flavor are arduous, and the heart, lung meridian are gone in cold.Logical all keys, the stagnated fire of loosing goes nebula to make eye bright, reducing swelling and alleviating pain.Control the apoplexy locked mouth, the calentura coma, infantile convulsion expectorant fan, gas is heard ear and is attacked sore throat, aphtha, otitis media, carbuncle, hemorrhoid, conjunctivitis, enterobiasis.Select for use Borax to have another name called Borax, fluffy sand, nature and flavor are sweet, salty, cold.Heat clearing away, expectorant, detoxifcation, anticorrosion.Be used for acute tonsillitis, pharyngolaryngitis, stomatitis, gingivitis, otitis media, conjunctival congestion and swelling pain, tinea versicolor.Select for use Indigo Naturalis to be because its nature and flavor are salty, cold, go into lung, lung, stomach warp.Heat clearing away, removing heat from blood, detoxifcation.Control the epidemic febrile disease intenseness of heat, macule is spitted blood, is spat blood, pediatric epilepsy scared, and skin ulcer is swollen, erysipelas, snake bite and insect sting.Select for use Realgar to be because its nature and flavor are arduous, temperature, poisonous, go into the heart, liver, stomach warp.Dampness is dispeled the wind, parasite killing, detoxifcation.Control scabies, tinea alba, carbuncle, acute gangrenous stomatitis, herpes zoster, tetanus, the snakeworm sting, internal organs is smelly, ecthyma, asthma, sore throat, infantile convulsion, hemorrhoid complicated by anal fistula.

The consumption of drug component of the present invention is also groped to sum up to draw through the inventor in a large number, and the consumption of each component all has better curative effect in following weight range:

Cortex Phellodendri 7-14g Radix Rehmanniae 7-14g

Radix Scrophulariae 7-14g Flos Lonicerae 7-14g

Fructus Forsythiae 8-15g Caulis Akebiae 3-8g

Fructus Gardeniae 10-16g Radix Sophorae Tonkinensis 7-14g

Rhizoma Coptidis 3-8g Radix Scutellariae 7-14g

Cortex Moutan 7-14g Gypsum Fibrosum 5-10g

Radix Glycyrrhizae 3-8g plate basket root 10-16g;

The medicine for external use BINGSHI looses, and consumption is:

Borneolum Syntheticum 25-35g Borax 100-150g

Indigo Naturalis 7-14g Realgar 5-10g.

Be preferably: Cortex Phellodendri 10g, Radix Rehmanniae 10g, Radix Scrophulariae 10g, Flos Lonicerae 10g, Fructus Forsythiae 12g, Caulis Akebiae 5g, Fructus Gardeniae 13g, Radix Sophorae Tonkinensis 10g, Rhizoma Coptidis 5g, Radix Scutellariae 10g, Cortex Moutan 10g, Gypsum Fibrosum 8g, Radix Glycyrrhizae 5g, Baphicacanthus cusia plate 13g.

The medicine for external use BINGSHI looses: Borneolum Syntheticum 30g, Borax 120g, Indigo Naturalis 10g, Realgar 8g.

The method for preparing of medicine of the present invention is following:

One, the preparation of bacillary stomatocace medicine:

(1) preparation of oral medicine:

1, be that Cortex Phellodendri, the Radix Rehmanniae, Radix Scrophulariae, Flos Lonicerae, Fructus Forsythiae, Caulis Akebiae, Fructus Gardeniae, Radix Sophorae Tonkinensis, Rhizoma Coptidis, Radix Scutellariae, Cortex Moutan, Gypsum Fibrosum, Radix Glycyrrhizae are put into marmite and add water 700ml with said weight proportion;

2, marmite is placed on the cooking stove boil with big fire earlier, the little fire of reuse decocted 15-20 minute.

(2) the diffusing preparation of medicine for external use BINGSHI:

1, Borax, the Realgar of said weight proportion are pulverized with herb roller respectively repeatedly, cross 200 mesh sieves;

2, Borneolum Syntheticum, the Indigo Naturalis with said weight proportion is milled to fine powder with beating bowl;

3, the Borax after will milling, Realgar, Borneolum Syntheticum and Indigo Naturalis are mixed and are mixed well.

Two, the preparation of viral stomatocace medicine:

(1) preparation of oral medicine:

1, Cortex Phellodendri, the Radix Rehmanniae, Radix Scrophulariae, Flos Lonicerae, Fructus Forsythiae, Caulis Akebiae, Fructus Gardeniae, Radix Sophorae Tonkinensis, Rhizoma Coptidis, Radix Scutellariae, Cortex Moutan, Gypsum Fibrosum, Radix Glycyrrhizae, the Radix Isatidis of said weight proportion are put into marmite and add water 700ml;

2, marmite is placed on the cooking stove boil with big fire earlier, the little fire of reuse decocts can be taken in 15-20 minute.

(2) the diffusing preparation of medicine for external use BINGSHI:

1, Borax, the Realgar of said weight proportion are pulverized with herb roller respectively repeatedly, cross 200 mesh sieves;

2, Borneolum Syntheticum, the Indigo Naturalis with said weight proportion is milled to fine powder with beating bowl;

3, the Borax after will milling, Realgar, Borneolum Syntheticum and Indigo Naturalis are mixed and are mixed well.

Medicine of the present invention has the function that clearing away heat-fire, antiinflammatory, antibacterial, removing heat from blood are held back skin ulcer, is used to treat dental ulcer of infant, laryngopharynx swelling and pain.

The specific embodiment:

Below come further to set forth the beneficial effect of medicine according to the invention, these tests to comprise that the animal experiment of medicine of the present invention and clinical observation on the therapeutic effect test through Test Example.

The animal experiment of [Test Example 1] medicine of the present invention

Get 20 of new zealand rabbits, male and female dual-purpose, body weight 2.0-2.5kg; Use the cotton swab that is immersed in the acetic acid to be pressed in middle modeling in 15 seconds of tongue of rabbit; Make the diameter 5mm of mucosa ulcer, rabbit is divided into 2 groups, 10 every group after making film; Wherein 1 group is the treatment group of using medicine of the present invention, and 1 group for using the treatment comparable group of Waterelon Frost Lozenges.

With the Waterelon Frost Lozenges porphyrize, be made into 157g/100ml with distilled water and supply rabbit treatment comparable group to use.Dosage is medicine 10g/kg of the present invention, Waterelon Frost Lozenges 15g/kg.

To treatment group and the administration of treatment comparable group, administering mode is a gastric infusion by above-mentioned dosage, and every day, secondary continuous 7 days, was observed local red and swollen symptom, exudate, ulcer healing time every day.

The result shows: form white ulcer after the rabbit modeling, white secretions occurred in per two days, viewing duration, the obvious unnecessary treatment group of treatment comparable group white secretions.The beginning in the 3rd day of treatment group secretions obviously reduces, and the ulcer area obviously dwindles, and all recoveries from illness after 8 days recover normal.Dead 1 of treatment comparable group is cured 7,2 of ulcer pathological changes.

The clinical observation material of [Test Example 2] Drug therapy dental ulcer of infant of the present invention

1, physical data:

Accept out-patient's totally 30 examples for medical treatment, wherein male 19 examples, women 11 examples, age 1-6 year 18 examples, 7-14 year 12 examples.

2, diagnostic criteria:

Light-duty bacillary aphtha: the about 2-3mm of diameter, number is less, and the abnormal pigmentary deposit on the skin trace is not stayed in healing.

The viral aphtha of stomatitis type: ulcer can reach tens or dozens of, can be with General Symptomies such as heatings.

3, Therapeutic Method:

Light-duty bacillary aphtha, oral bacillary stomatocace medicine; The viral aphtha of stomatitis type, oral viral stomatocace medicine.

1-6 year, every day 4 times, each 2-15ml, logotype 3-7 days.

7-14 year, every day 4 times, each 20-50ml, logotype 3-7 days.

Extract medicinal liquid in the marmite by above-mentioned weight when taking medicine and take, when taking medicine once more, the medicinal liquid in the marmite is boiled and can take, the continuous after a little while water of water.Slight patient is promptly healed for one pair, patient with severe symptoms Second Mate recovery from illness.

After taking medicine at every turn, get the diffusing 0.1-0.2g of BINGSHI again and be spread on containing on the ulcer surface.

4, treatment evaluation criteria:

Produce effects: various aphtha is after treatment, and the ulcer surface healing recovers normal, observes 3 months no recidivists.

Take a turn for the better: healing time is accelerated, and pain degree alleviates, and ulcer decreased number and diameter diminish.

Invalid: as not reach improvement standard person.

5, therapeutic outcome: see the following form

In 7 days medication treatment, light-duty bacillary aphtha 10 examples, produce effects 10 examples as a result, obvious effective rate is 100%; Viral aphtha 20 examples of stomatitis type, produce effects 16 examples as a result, 3 examples that take a turn for the better, invalid 1 example, obvious effective rate is 80%, improvement rate 15%, total effective rate are 95%.

Claims (3)

1. medicine of treating dental ulcer of infant, it is characterized in that: it is to be processed by crude drug for oral administration in the following weight range and external crude drug:

1. crude drug for oral administration:

Cortex Phellodendri 7-14g Radix Rehmanniae 7-14g

Radix Scrophulariae 7-14g Flos Lonicerae 7-14g

Fructus Forsythiae 8-15g Caulis Akebiae 3-8g

Fructus Gardeniae 10-16g Radix Sophorae Tonkinensis 7-14g

Rhizoma Coptidis 3-8g Radix Scutellariae 7-14g

Cortex Moutan 7-14g Gypsum Fibrosum 5-10g

Radix Glycyrrhizae 3-8g plate basket root 10-16g;

2. the medicine for external use BINGSHI looses:

Borneolum Syntheticum 25-35g Borax 100-150g

Indigo Naturalis 7-14g Realgar 5-10g.

2. according to the medicine of claim 1, wherein the consumption of each crude drug is: crude drug 1. for oral administration: Cortex Phellodendri 10g, Radix Rehmanniae 10g, Radix Scrophulariae 10g, Flos Lonicerae 10g; Fructus Forsythiae 12g, Caulis Akebiae 5g, Fructus Gardeniae 13g, Radix Sophorae Tonkinensis 10g, Rhizoma Coptidis 5g; Radix Scutellariae 10g, Cortex Moutan 10g, Gypsum Fibrosum 8g, Radix Glycyrrhizae 5g, Radix Isatidis 13g; 2. the medicine for external use BINGSHI looses: Borneolum Syntheticum 30g, Borax 120g, Indigo Naturalis 10g, Realgar 8g.

3. according to the method for preparing of claim 1 or 2 said medicines, it is characterized in that: it comprises the following steps:

(1) preparation of bacillary stomatocace medicine:

A. the preparation of oral medicine:

1. be that Cortex Phellodendri, the Radix Rehmanniae, Radix Scrophulariae, Flos Lonicerae, Fructus Forsythiae, Caulis Akebiae, Fructus Gardeniae, Radix Sophorae Tonkinensis, Rhizoma Coptidis, Radix Scutellariae, Cortex Moutan, Gypsum Fibrosum, Radix Glycyrrhizae are put into marmite and add water 700ml with said weight proportion;

2. marmite is placed on the cooking stove and boil with big fire earlier, the little fire of reuse decocted 15-20 minute;

B. the diffusing preparation of medicine for external use BINGSHI:

1. Borax, the Realgar of said weight proportion are pulverized with herb roller respectively repeatedly, cross 200 mesh sieves;

2. Borneolum Syntheticum, the Indigo Naturalis with said weight proportion is milled to fine powder with beating bowl;

3. the Borax after will milling, Realgar, Borneolum Syntheticum and Indigo Naturalis mixing are mixed well;

(2) preparation of viral stomatocace medicine:

A. the preparation of oral medicine:

1. Cortex Phellodendri, the Radix Rehmanniae, Radix Scrophulariae, Flos Lonicerae, Fructus Forsythiae, Caulis Akebiae, Fructus Gardeniae, Radix Sophorae Tonkinensis, Rhizoma Coptidis, Radix Scutellariae, Cortex Moutan, Gypsum Fibrosum, Radix Glycyrrhizae, the Radix Isatidis of said weight proportion are put into marmite and add water 700ml;

2. marmite is placed on the cooking stove and boil with big fire earlier, the little fire of reuse decocted 15-20 minute;

B. the diffusing preparation of medicine for external use BINGSHI:

1. Borax, the Realgar of said weight proportion are pulverized with herb roller respectively repeatedly, cross 200 mesh sieves;

2. Borneolum Syntheticum, the Indigo Naturalis with said weight proportion is milled to fine powder with beating bowl;

3. the Borax after will milling, Realgar, Borneolum Syntheticum and Indigo Naturalis mixing are mixed well.