CN104758773A - Traditional Chinese medicine preparation for treating hand-foot-and-mouth disease - Google Patents

Abstract

The invention belongs to the technical field of traditional Chinese medicines and particularly relates to a traditional Chinese medicine preparation for treating hand-foot-and-mouth disease. The traditional Chinese medicine preparation is prepared from honeysuckle, radix asparagi, suberect spatholobus stem, poria cocos, Chinese violet, dendrobe, cyrtomium fortune, isatis root, tea tree root, dandelion, honeysuckle stem, jasmine, turnip, mint, groundsel, rose, folium isatidis, common bluebeard herb, momordica grosvenori, fructus forsythia, junci medulla, oriental wormwood and the like. The traditional Chinese medicine composition disclosed by the invention selects pure natural traditional Chinese medicine raw materials, has the effects of regulating the spleen and the stomach, clearing away heat and toxic materials and resisting viruses, is free of toxic or side effects, the active ingredients of the medicines are easy to release, quick to absorb and easy to take. Moreover, the traditional Chinese medicine preparation further has the functions of regulating the body and strengthening the immunity, and is beneficial to rehabilitation of infant hand-foot-and-mouth disease.

Description

A kind of Chinese medicine preparation for the treatment of hand-foot-mouth disease

Technical field

The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine preparation for the treatment of hand-foot-mouth disease.

Background technology

Hand-foot-mouth disease is the infectious disease caused by enterovirus, and causing the enterovirus of hand-foot-mouth disease has kind more than 20 (type), wherein with coxsackie virus A 16-type (Cox A16) and enterovirns type 71 (EV 71) the most common.Multiplely be born in less than 5 years old child, there is exanthema vesiculosum or aphtha, the spontaneous recovery in about one week of most infant in the positions such as performance stomatalgia, anorexia, low grade fever, hands, foot, oral cavity, minority infant can cause the complication such as myocarditis, pulmonary edema, AME.Indivedual children with serious disease PD is fast, causes death.The main symptomatic treatment of the effective medicine of current shortage.

Due to hand-foot-mouth disease, patient has oral ulcer more, causes the problem such as stomatalgia, sialorrhea, refusing to eat, anorexia, and the little oral solid formulation of children age is difficult in addition again, and large drug exists side effect in various degree, affects the normal g and D of infant.Therefore clinical one of needing badly can effectively be hited pathogenesis, accelerate infant heating, deflorescence, promote clinical recovery, at utmost reduce the Chinese medicine preparation of infants' pain.

Summary of the invention

In order to overcome deficiency of the prior art, the invention provides a kind of Chinese medicine preparation of evident in efficacy, treatment hand-foot-mouth disease that toxic and side effects is little.

In order to solve the problems of the technologies described above, the technical solution used in the present invention is as follows: a kind of Chinese medicine preparation for the treatment of hand-foot-mouth disease, be made up of each component of following parts by weight: Flos Lonicerae 2-15 part, Radix Asparagi 1-9 part, Caulis Spatholobi 1-10 part, Poria 1-5 part, Herba Violae 1-7 part, Herba Dendrobii 1-5 part, Rhizoma Osmundae 1-3 part, Radix Isatidis 1-15 part, Radix Camelliae sinensis 1-4 part, Herba Taraxaci 2-20 part, Caulis Lonicerae 2-7 part, Fructus Gardeniae 1-4 part, Radix Brassicae rapae 2-10 part, Herba Menthae 1-8 part, Herba Senecionis Scandentis 2-8 part, Flos Rosae Multiflorae 1-13 part, Folium Isatidis 2-7 part, Herba Caryopteridis Incanae 1-3 part, Fructus Momordicae 1-3 part, leaf Fructus Ligustri Lucidi 2-10 part, Fructus Forsythiae 1-7 part, Medulla Junci 1-5 part, Herba Artemisiae Scopariae 2-7 part, Periostracum Cicadae 3-6 part, Radix Caulophylli 1-4 part, Semen Coicis 2-11 part, Rhizoma Imperatae 2-6 part, Rhizoma Atractylodis 1-6 part, Radix agastaches 2-5 part, Rhizoma Kaempferiae 2-6 part, Fructus Alpiniae Oxyphyllae 2-15 part, Radix Scutellariae 2-12 part, Radix Codonopsis 1-3 part, Rhizoma Chuanxiong 2-6 part, Radix Glycyrrhizae 2-13 part, Radix Pseudostellariae 1-3 part, Fructus Mume 2-8 part.

Further, the present invention is made up of each component of following parts by weight:

Flos Lonicerae 2-10 part, Radix Asparagi 1-5 part, Caulis Spatholobi 1-8 part, Poria 1-4 part, Herba Violae 1-5 part, Herba Dendrobii 1-3 part, Rhizoma Osmundae 1-3 part, Radix Isatidis 1-10 part, Radix Camelliae sinensis 1-4 part, Herba Taraxaci 2-15 part, Caulis Lonicerae 2-7 part, Fructus Gardeniae 1-4 part, Radix Brassicae rapae 2-10 part, Herba Menthae 1-5 part, Herba Senecionis Scandentis 2-5 part, Flos Rosae Multiflorae 1-10 part, Folium Isatidis 2-7 part, Herba Caryopteridis Incanae 1-3 part, Fructus Momordicae 1-3 part, leaf Fructus Ligustri Lucidi 2-10 part, Fructus Forsythiae 1-7 part, Medulla Junci 1-5 part, Herba Artemisiae Scopariae 2-7 part, Periostracum Cicadae 3-6 part, Radix Caulophylli 1-4 part, Semen Coicis 2-8 part, Rhizoma Imperatae 2-6 part, Rhizoma Atractylodis 1-6 part, Radix agastaches 2-5 part, Rhizoma Kaempferiae 2-6 part, Fructus Alpiniae Oxyphyllae 2-10 part, Radix Scutellariae 2-10 part, Radix Codonopsis 1-3 part, Rhizoma Chuanxiong 2-6 part, Radix Glycyrrhizae 2-10 part, Radix Pseudostellariae 1-3 part, Fructus Mume 2-8 part.

Further, the present invention is made up of each component of following parts by weight: Flos Lonicerae 5 parts, Radix Asparagi 1 part, Caulis Spatholobi 1 part, 1 part, Poria, Herba Violae 1 part, Herba Dendrobii 1 part, Rhizoma Osmundae 3 parts, Radix Isatidis 5 parts, Radix Camelliae sinensis 4 parts, Herba Taraxaci 6 parts, Caulis Lonicerae 2 parts, Fructus Gardeniae 1 part, Radix Brassicae rapae 2 parts, Herba Menthae 3 parts, Herba Senecionis Scandentis 2 parts, Flos Rosae Multiflorae 1 part, Folium Isatidis 2 parts, Herba Caryopteridis Incanae 1 part, Fructus Momordicae 1 part, leaf Fructus Ligustri Lucidi 2 parts, Fructus Forsythiae 1 part, Medulla Junci 1 part, Herba Artemisiae Scopariae 2 parts, Periostracum Cicadae 3 parts, Radix Caulophylli 1 part, Semen Coicis 8 parts, Rhizoma Imperatae 2 parts, Rhizoma Atractylodis 1 part, Radix agastaches 2 parts, Rhizoma Kaempferiae 2 parts, Fructus Alpiniae Oxyphyllae 5 parts, Radix Scutellariae 2 parts, Radix Codonopsis 1 part, Rhizoma Chuanxiong 2 parts, 8 parts, Radix Glycyrrhizae, Radix Pseudostellariae 1 part, Fructus Mume 5 parts.

Further, medicament of the present invention is any one dosage form described in pharmaceutics.

Further, medicament of the present invention is decoction or pill.

Further, the pharmaceutical dosage form of this formula of the present invention is granule, capsule, tablet or oral liquid.

Further, the preparation of pharmaceutical dosage form of the present invention comprises the steps:

(1) Flos Lonicerae, Radix Asparagi, Caulis Spatholobi, Poria, Herba Violae, Herba Dendrobii, Rhizoma Osmundae, Radix Isatidis, Radix Camelliae sinensis, Herba Taraxaci, Caulis Lonicerae, Fructus Gardeniae, Radix Brassicae rapae, Herba Menthae, Herba Senecionis Scandentis, Flos Rosae Multiflorae, Folium Isatidis, Herba Caryopteridis Incanae, Fructus Momordicae, leaf Fructus Ligustri Lucidi, Fructus Forsythiae, Medulla Junci, Herba Artemisiae Scopariae, Periostracum Cicadae, Radix Caulophylli, Semen Coicis, Rhizoma Imperatae, Rhizoma Atractylodis, Radix agastaches, Rhizoma Kaempferiae, Fructus Alpiniae Oxyphyllae, Radix Scutellariae, Radix Codonopsis, Rhizoma Chuanxiong, Radix Glycyrrhizae, Radix Pseudostellariae, Fructus Mume adds 5 ~ 20 times of soak by water three times, the each 0.5-3 hour of decocting time, collecting decoction, filter, filtrate reduced in volume becomes thick extractum, relative density is 1.25 ~ 1.30 (60 DEG C), again by thick extractum, 30 ~ 90 DEG C of drying under reduced pressure become dry extract, pulverize 200 mesh sieves and obtain extract dry extract,

(2) said extracted thing dry extract, cross 20 mesh sieves granulations, granulate, obtain dry granule;

(3) dry granule and corresponding auxiliary materials and mixing, make required dosage form.

The Chinese medicine that the present invention adopts has following pharmacological action:

Flos Lonicerae

Nature and flavor: sweet, cold.

Gui Jing: return lung, the heart, stomach warp.

Function cures mainly: heat-clearing and toxic substances removing, wind-heat dissipating.For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat.

Radix Asparagi

Nature and flavor: sweet in the mouth; Bitter; Cold in nature

Gui Jing: lung; Kidney channel

Function cures mainly: nourshing Yin and drynsessmoistening prescription; Lung heat clearing pathogenic fire reducing.Main cough caused by dryness-heat; Deficiency of YIN chronic cough; Consumption of YIN caused by febrile disease; Interior-heat is quenched one's thirst; Dryness of the intestine constipation; Laryngopharynx swelling and pain.

Caulis Spatholobi

Nature and flavor: bitter, sweet, temperature.

Gui Jing: return liver, kidney channel.

Function cures mainly: enrich blood, and invigorates blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.

Poria

Nature and flavor: sweet, light are flat.

Gui Jing: GUIXIN, lung, spleen, kidney channel.

Function cures mainly: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.

Herba Violae

Nature and flavor: bitter, acrid, cold.

Gui Jing: GUIXIN, Liver Channel.

Function cures mainly: heat-clearing and toxic substances removing, and removing heat from blood is subsided a swelling.For furuncle swelling toxin, carbuncle carbuncle on the back, erysipelas, venom.

Herba Dendrobii

Nature and flavor: sweet, are slightly cold.

Gui Jing: return stomach, kidney channel.

Function cures mainly: reinforcing stomach reg fluid, nourishing YIN and clearing away heat.Lose for cloudy impairment of body fluid, xerostomia excessive thirst, lack of appetite is retched, deficiency-heat after being ill, poor vision.

Rhizoma Osmundae

Nature and flavor: bitter; Puckery; Be slightly cold; Slightly poisonous

Gui Jing: liver; Stomach warp

Function cures mainly: parasite killing; Heat clearing away; Removing toxic substances; Cooling blood for hemostasis.Main anemopyretic cold; Warm skin eruption; Spit blood; Hemoptysis; Epistaxis; Have blood in stool; Metrorrhagia; Dysentery; The intestinal parasitic diseases such as leukorrhagia and hook, ascarid, cestode.

Radix Isatidis

Nature and flavor: bitter, cold.

Gui Jing: GUIXIN, stomach warp.

Function cures mainly: heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.For maculae caused by violent heat pathogen, crimson tongue is purple dark, mumps, sore throat, scarlet fever, major part pestilence, erysipelas, carbuncle.

Radix Camelliae sinensis

Nature and flavor: bitter; Cool

Gui Jing: the heart; Kidney channel

Function cures mainly: heart tonifying diuresis; Promoting blood flow to regulate menstruation; Heat-clearing and toxic substances removing.Main heart disease; Edema; Hepatitis; Dysmenorrhea; Sore swollen toxin; Aphtha; Soup fire is burnt; Herpes zoster; Psoriasis.

Herba Taraxaci

Nature and flavor: bitter, sweet, cold.

Gui Jing: return liver, stomach warp.

Function cures mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome.For furuncle swelling toxin, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, lung abscess, acute appendicitis, jaundice due to damp-heat, the puckery pain of pyretic stranguria.

Caulis Lonicerae

Nature and flavor: sweet, cold.

Gui Jing: attach to the lung and stomach meridians.

Function cures mainly: heat-clearing and toxic substances removing, dispelling wind dredging collateral.For epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle skin infection, beriberoid pyretic arthralgia, redness and swelling of joints burning pain.

Fructus Gardeniae

Nature and flavor: bitter, cold.

Gui Jing: GUIXIN, lung, tri-jiao channel.

Function cures mainly: fruit: pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Vexed for calentura, jaundice dark coloured urine, blood strangury and dry pain, heat in blood tells nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.

Radix Brassicae rapae

Nature and flavor: bitter; Pungent; Sweet; Temperature

Gui Jing: the heart; Lung; Spleen; Stomach warp

Function cures mainly: removing stagnancy of indigested food and making QI downward, removing toxic substances and promoting subsidence of swelling.Main indigestion; Trusted subordinate's cold type of pain; Cough; Furuncle carbuncle.

Herba Menthae

Nature and flavor: pungent are cool.

Gui Jing: return lung, Liver Channel.

Function cures mainly: dispelling wind-heat.Refresh oneself, rash.For anemopyretic cold, pathogenic wind-warm from the beginning of, headache, conjunctival congestion, sore throat, aphtha, rubella, measles, breast the side of body feeling of distension and oppression.

Herba Senecionis Scandentis

Nature and flavor: bitter in the mouth; Pungent; Cold in nature

Function cures mainly: heat-clearing and toxic substances removing; Improving acuity of vision and removing nebula; Killing parasites for relieving itching.Main flow sense; Upper respiratory tract infection; Pneumonia; Acute tonsillitis; Rib adenitis; Acute enteritis; Bacillary dysentery; Icterohepatitis; Gallbladder exudative dermatitis is scorching; Acute urinary tract infection; Conjunctival congestion and swelling pain cataracta; Carbuncle furuncle poison; Erysipelas; Eczema; Dry exudative dermatitis skin ulcer; Trichomonal vaginitis; Burn and scald.

The Flos rosae multiflorae

Nature and flavor: bitter, puckery; Cool

Gui Jing: stomach; Large intestine channel

Function cures mainly: clearing away summer-heat, stomach function regulating, promoting blood circulation and hemostasis, removing toxic substances.Main summer-heat excessive thirst; Epigastric distension and distress, spits blood, epistaxis, aphtha, carbuncle furuncle, menoxenia.

Folium Isatidis

Nature and flavor: bitter, cold.

Gui Jing: GUIXIN, stomach warp.

Function cures mainly: heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.Join the army for pathogenic warmth, unconsciousness due to high fever, sends out speckle dermexanthesis, jaundice, hematodiarrhoea, mumps, sore throat, erysipelas, carbuncle.

Herba Caryopteridis Incanae

Nature and flavor: pungent, temperature.

Function cures mainly: dispelling wind to relieve the exterior syndrome, expelling phlegm for arresting cough, scattered silt pain relieving.For upper respiratory tract infection, pertussis, bronchitis, rheumatic arthritis, gastroenteritis, treating swelling and pain by traumatic injury, puerperal abdominalgia with blood stasis; Venom is controlled in external, eczema, skin itching.

Fructus Momordicae

Nature and flavor: sweet are cool.

Gui Jing: return lung, large intestine channel.

Function cures mainly: clearing heat and moistening lung, laxation relieving constipation.For lung-fire cough caused by dryness, pharyngalgia aphonia, dryness of the intestine constipation.

Leaf Fructus Ligustri Lucidi

Nature and flavor: bitter; Micro-sweet; Cold nature

Gui Jing: liver; Gallbladder; Stomach warp

Function cures mainly: loose wind heat; Refresh oneself; Relieving thirst and restlessness.Main headache; Toothache; Pharyngalgia; Lip boil; Tinnitus; Conjunctival congestion; Spitting of blood; Summer-heat excessive thirst.

Fructus Forsythiae

Nature and flavor: bitter, are slightly cold.

Gui Jing: return lung, the heart, small intestine meridian.

Effect: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warmly join the army, high hot excessive thirst, coma sends out speckle, pyretic stranguria urine retention.

Medulla Junci

Nature and flavor: sweet, light, are slightly cold.

Gui Jing: GUIXIN, lung, small intestine meridian.

Function cures mainly: clearing away heart-fire, diuresis.For vexed insomnia, the puckery pain of oliguria, aphtha of the mouth and tongue.

Herba Artemisiae Scopariae

Nature and flavor: bitter, pungent, are slightly cold.

Gui Jing: return spleen, stomach, liver, gallbladder meridian.

Function cures mainly: clearing away damp-heat, jaundice eliminating subcutaneous ulcer.For jaundice oliguria, eczema pruritus; Infectious jaundice type hepatitis.

Periostracum Cicadae

Nature and flavor: sweet, cold.

Gui Jing: return lung, Liver Channel.

Function cures mainly: loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.For anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, tetanus.

Radix Caulophylli

Nature and flavor: pungent; Bitter; Warm in nature

Gui Jing: liver; Stomach warp

Function cures mainly: promoting blood circulation to remove blood stasis; Expelling wind and removing dampness; Promoting the circulation of QI to relieve pain.Main menoxenia; Dysmenorrhea; Puerperal abdominal pain due to blood stasis; The cold pain of gastral cavity abdomen; Traumatic injury, rheumatic arthralgia.

Semen Coicis

Nature and flavor: sweet, light, cool.

Gui Jing: return spleen, stomach, lung meridian.

Function cures mainly: spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, and row is dense in heat clearing away.For edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana.

Rhizoma Imperatae

Nature and flavor: sweet, cold.

Gui Jing: return lung, stomach, urinary bladder channel.

Function cures mainly: cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria; Acute nephritis edema.

Rhizoma Atractylodis

Nature and flavor: pungent, bitter, temperature.

Gui Jing: return spleen, stomach, Liver Channel.

Function cures mainly: drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For distension and fullness in the abdomen, have loose bowels, edema, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.

Radix agastaches

Nature and flavor with return through: pungent, tepor.Return spleen, stomach, lung meridian.

Function with cure mainly: eliminating turbid pathogen with aromatics, and middle preventing or arresting vomiting, deliver expelling summer-heat.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is vomitted, heat-damp in summer exterior syndrome, hygropyrexia from the beginning of, heating asthenia, uncomfortable in chestly do not relax, cold-damp closes summer-heat, and stomachache is vomited and diarrhoea, nasosinusitis headache.

Rhizoma Kaempferiae

Meridian distribution of property and flavor: pungent, temperature.Return stomach warp.

Function cures mainly: circulation of qi promoting warming middle-JIAO, helps digestion, pain relieving.For septum pectorale distension, coldness and pain in the epigastrium, diet does not disappear.

Fructus Alpiniae Oxyphyllae

Nature and flavor: acrid in the mouth; Warm in nature

Gui Jing: spleen; Kidney channel

Function cures mainly: warming spleen and stopping diarrhaly take the photograph saliva; Warming the kidney reducing urination controlling nocturnal emission with astringent drugs.Main Deficiency and coldness of spleen and stomach; Vomiting; Have loose bowels; Coldly in abdomen to educate; The many salivas of mouth; Enuresis due to deficiency of the kidney; Frequent micturition; Seminal emission; Nebulousurine.

Radix Scutellariae

Nature and flavor: bitter, cold.

Gui Jing: return lung, gallbladder, spleen, large intestine, small intestine meridian.

Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.

Radix Codonopsis

Nature and flavor: sweet are flat.

Gui Jing: return spleen, lung meridian.

Function cures mainly: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.

Rhizoma Chuanxiong

Nature and flavor: pungent, temperature.

Gui Jing: return liver, gallbladder, pericardium channel.

Function cures mainly: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.

Radix Glycyrrhizae

Nature and flavor: sweet are flat.

Gui Jing: GUIXIN, lung, spleen, stomach warp.

Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Radix Pseudostellariae

Nature and flavor: sweet, micro-hardship are flat.

Gui Jing: return spleen, lung meridian.

Function cures mainly: replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung.Tired for insufficiency of the spleen body, inappetence, weak after being ill, deficiency of both vital energy and Yin, spontaneous perspiration is thirsty, dryness of the lung dry cough.

Fructus Mume

Nature and flavor: sour, puckery are flat.

Gui Jing: return liver, spleen, lung, large intestine channel.

Function cures mainly: astringe the lung, and astringing intestine to stop diarrhea promotes the production of body fluid, relieving colic caused by ascaris.For chronic cough of deficiency lung, chronic dysentery laxation, deficiency-heat is quenched one's thirst, ascariasis of biliary tract vomiting stomachache, ascariasis of biliary tract.

Chinese medicine composition of the present invention selects natural Chinese medicines raw material, and have and well regulate taste, heat-clearing and toxic substances removing, antiviral effect, have no side effect, effective ingredient easily discharges, and absorbs fast, is easy to take.And Chinese medicine composition of the present invention can also adjust body, strengthen immunologic function, be conducive to the rehabilitation of Hand-Food-Mouth Disease.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further elaborated.

Embodiment 1

The present invention includes following weight item: Rhizoma Chuanxiong 6 parts, the Cortex Eucommiae 4 parts, Rhizoma Coptidis 4 parts, Ganoderma 4 parts, Cortex Moutan 4 parts, Semen Sinapis Albae 4 parts, 3 parts, Rhizoma Gastrodiae, Fructus Canarii Pimelae 3 parts, 8 parts, Radix Notoginseng, 5 parts, Folium Nelumbinis, Ramulus Uncariae Cum Uncis 10 parts, Juncus effcus 3 parts, Semen Cassiae 7 parts, Flos Chrysanthemi 3 parts, the Cortex Eucommiae 4 parts, Herb Gynostemmae Pentaphylli 5 parts, the Radix Paeoniae Alba 2 parts, Herba Lysimachiae 7 parts, 3 parts, Folium Bambusae, Rhizoma Phragmitis 4 parts, Radix Isatidis 5 parts, 3 parts, the Radix Rehmanniae, Herba Apocyni veneti 7 parts, Stigma Maydis 7 parts, Herba nepenthis 8 parts, Radix Achyranthis Bidentatae 4 parts, Concha Ostreae 3 parts, YIDUOYUN 4 parts, Fructus Lycii 10 parts, Spica Prunellae 5 parts, Fructus Crataegi 6 parts, Folium Ginkgo 9 parts.

The present embodiment Chinese medicine preparation is pill, preparation process: get above-mentioned Chinese medicine and clean, water boiling and extraction three times, each amount of water is 6 of Chinese medicine weight, and each decocting time is 0.5 hour, collecting decoction, filter, when filtrate is condensed into 60 DEG C, relative density is the extractum of 1.15-1.18; Mixed with suitable pill adjuvant by extractum, technique makes pill routinely.

Embodiment 2

The present invention includes following weight item: Rhizoma Chuanxiong 9 parts, the Cortex Eucommiae 3 parts, Rhizoma Coptidis 1 part, Ganoderma 1 part, Cortex Moutan 1 part, Semen Sinapis Albae 4 parts, 5 parts, Rhizoma Gastrodiae, Fructus Canarii Pimelae 4 parts, 3 parts, Radix Notoginseng, 6 parts, Folium Nelumbinis, Ramulus Uncariae Cum Uncis 4 parts, Juncus effcus 3 parts, Semen Cassiae 6 parts, Flos Chrysanthemi 2 parts, the Cortex Eucommiae 2 parts, Herb Gynostemmae Pentaphylli 4 parts, the Radix Paeoniae Alba 2 parts, Herba Lysimachiae 7 parts, 4 parts, Folium Bambusae, Rhizoma Phragmitis 2 parts, Radix Isatidis 9 parts, 7 parts, the Radix Rehmanniae, Herba Apocyni veneti 8 parts, Stigma Maydis 6 parts, Herba nepenthis 7 parts, Radix Achyranthis Bidentatae 11 parts, Concha Ostreae 1 part, YIDUOYUN 3 parts, Fructus Lycii 12 parts, Spica Prunellae 4 parts, Fructus Crataegi 6 parts, Folium Ginkgo 7 parts.

The present embodiment Chinese medicine preparation is pill, preparation process: get above-mentioned Chinese medicine and clean, water boiling and extraction three times, each amount of water is 5 times of Chinese medicine weight, and each decocting time is 0.5 hour, collecting decoction, filter, when filtrate is condensed into 60 DEG C, relative density is the extractum of 1.15-1.18; Mixed with suitable pill adjuvant by extractum, technique makes pill routinely.

Embodiment 3

The present invention includes following weight item: Rhizoma Chuanxiong 8 parts, the Cortex Eucommiae 4 parts, Rhizoma Coptidis 1 part, Ganoderma 1 part, Cortex Moutan 4 parts, Semen Sinapis Albae 10 parts, 1 part, Rhizoma Gastrodiae, Fructus Canarii Pimelae 1 part, 10 parts, Radix Notoginseng, 15 parts, Folium Nelumbinis, Ramulus Uncariae Cum Uncis 4 parts, Juncus effcus 3 parts, Semen Cassiae 6 parts, Flos Chrysanthemi 3 parts, the Cortex Eucommiae 2 parts, Herb Gynostemmae Pentaphylli 4 parts, the Radix Paeoniae Alba 2 parts, Herba Lysimachiae 7 parts, 4 parts, Folium Bambusae, Rhizoma Phragmitis 2 parts, Radix Isatidis 9 parts, 7 parts, the Radix Rehmanniae, Herba Apocyni veneti 8 parts, Stigma Maydis 6 parts, Herba nepenthis 7 parts, Radix Achyranthis Bidentatae 11 parts, Concha Ostreae 1 part, YIDUOYUN 4 parts, Fructus Lycii 6 parts, Spica Prunellae 10 parts, Fructus Crataegi 10 parts, Folium Ginkgo 10 parts.

The present embodiment Chinese medicine preparation is pill, preparation process: get above-mentioned Chinese medicine and clean, water boiling and extraction three times, each amount of water is 8 times of Chinese medicine weight, and each decocting time is 3 hours, collecting decoction, filter, when filtrate is condensed into 60 DEG C, relative density is the extractum of 1.15-1.18; Mixed with suitable pill adjuvant by extractum, technique makes pill routinely.

Embodiment 4

The present invention includes following weight item:

Rhizoma Chuanxiong 8 parts, the Cortex Eucommiae 4 parts, Rhizoma Coptidis 1 part, Ganoderma 1 part, Cortex Moutan 5 parts, Semen Sinapis Albae 8 parts, 6 parts, Rhizoma Gastrodiae, Fructus Canarii Pimelae 1 part, 4 parts, Radix Notoginseng, 15 parts, Folium Nelumbinis, Ramulus Uncariae Cum Uncis 11 parts, Juncus effcus 8 parts, Semen Cassiae 11 parts, Flos Chrysanthemi 12 parts, the Cortex Eucommiae 6 parts, Herb Gynostemmae Pentaphylli 11 parts, the Radix Paeoniae Alba 3 parts, Herba Lysimachiae 10 parts, 7 parts, Folium Bambusae, Rhizoma Phragmitis 4 parts, Radix Isatidis 5 parts, 3 parts, the Radix Rehmanniae, Herba Apocyni veneti 7 parts, Stigma Maydis 7 parts, Herba nepenthis 8 parts, Radix Achyranthis Bidentatae 4 parts, Concha Ostreae 3 parts, YIDUOYUN 4 parts, Fructus Lycii 10 parts, Spica Prunellae 5 parts, Fructus Crataegi 7 parts, Folium Ginkgo 11 parts.

The present embodiment Chinese medicine preparation is pill, preparation process: get above-mentioned Chinese medicine and clean, water boiling and extraction three times, each amount of water is 7 times of Chinese medicine weight, and each decocting time is 1 hour, collecting decoction, filter, when filtrate is condensed into 60 DEG C, relative density is the extractum of 1.15-1.18; Mixed with suitable pill adjuvant by extractum, technique makes pill routinely.

Embodiment 5

The present invention includes following weight item:

Rhizoma Chuanxiong 9 parts, the Cortex Eucommiae 5 parts, Rhizoma Coptidis 1 part, Ganoderma 1 part, Cortex Moutan 1 part, Semen Sinapis Albae 11 parts, 8 parts, Rhizoma Gastrodiae, Fructus Canarii Pimelae 1 part, 10 parts, Radix Notoginseng, 1 part, Folium Nelumbinis, Ramulus Uncariae Cum Uncis 3 parts, Juncus effcus 1 part, Semen Cassiae 15 parts, Flos Chrysanthemi 5 parts, the Cortex Eucommiae 1 part, Herb Gynostemmae Pentaphylli 15 parts, the Radix Paeoniae Alba 10 parts, Herba Lysimachiae 11 parts, 15 parts, Folium Bambusae, Rhizoma Phragmitis 10 parts, Radix Isatidis 10 parts, 1 part, the Radix Rehmanniae, Herba Apocyni veneti 10 parts, Stigma Maydis 11 parts, Herba nepenthis 9 parts, Radix Achyranthis Bidentatae 5 parts, Concha Ostreae 5 parts, YIDUOYUN 15 parts, Fructus Lycii 15 parts, Spica Prunellae 10 parts, Fructus Crataegi 10 parts, Folium Ginkgo 10 parts.

The present embodiment Chinese medicine preparation is pill, preparation process: get above-mentioned Chinese medicine and clean, water boiling and extraction three times, each amount of water is 6 times of Chinese medicine weight, and each decocting time is 0.5 hour, collecting decoction, filter, when filtrate is condensed into 60 DEG C, relative density is the extractum of 1.15-1.18; Mixed with suitable pill adjuvant by extractum, technique makes pill routinely.

Clinical efficacy:

One, the present invention is extensive in clinical practice for many years, treats routine patient up to a hundred, evident in efficacy.

Two, diagnostic criteria: the incubation period of hand-foot-mouth disease is 2 ~ 7.Acute onset, heating, oral mucosa occurs being dispersed in herpes, and maculopapule, herpes appear in hands, foot and buttocks, and can have inflammatory blush around herpes, in bleb, liquid is less.Some meetings are with symptoms such as cough, watery nasal discharge, inappetence.Some case only shows as erythra or herpangina.Patient's herpes liquid, defecate separable to enterovirus.

Three, administrated method: pill patient being fed to embodiment 1, one day three times, a week is a course for the treatment of.

Four, efficacy evaluation:

Cure: clinical symptoms disappears completely, lab testing recovers normal.

Take a turn for the better: clinical symptoms and sign are improved, and lab testing Pathogenic enteric virus is controlled substantially.

Do not heal: clinical symptoms is without improvement or increase the weight of.

Cure: clinical symptoms disappears completely, lab testing recovers normal.

Therapeutic effect: treatment by Chinese herbs primary disease of the present invention, through statistics cure rate 99%, effective percentage more than 90%.

Concrete case

Case 1

1, Zhang, female, 6 years old, before 3 days there is pimple, get blister in trick, and oral cavity is rubescent, takes food poor, has a fever 38 DEG C, after eating febrifuge, again repeatedly.Check: serum-virus is separated visible enterovirus.After taking a course for the treatment of of the present invention, clinical symptoms disappears completely, and lab testing recovers normal, follows up a case by regular visits to half a year and does not recur again.

Case 2

Lu, female, 2 years old, herpes did not disappear, and face lip side ulcer, can not dehisce, and confirmed as hand-foot-mouth disease.Check: serum-virus is separated visible enterovirus.After taking 2 courses for the treatment of of the present invention, can dehisce to eat food, incrustation subsequently comes off, recovery from illness.

Case 3

Wang, female, 4 years old, finds the position such as buttocks and external genitalia on inspection, all occurs Semen phaseoli radiati grain size, rubescent canescence exanthema vesiculosum around, with heating; Through being diagnosed as hand-foot-mouth disease, take the present invention and take effect for 2 days, after the course for the treatment of, red papules shape disappears completely, afterwards rehabilitation.

Case 4

Grandson so-and-so, man, 3 years old.This infant is positioned at tongue, pharynx rear wall and two buccals on inspection vesicle, has blush around, and herpes ulceration, and hands, foot and buttocks have kermesinus maculopapule, and with pharyngalgia, heating paresthesia, are diagnosed as hand-foot-mouth disease.Take Chinese medicine of the present invention to take effect for 2 days, fully recover after the course for the treatment of.

Case 5

Dong so-and-so, female, 6 years old, go to a doctor in August, 2010, there is maculopapule, herpes in hands, foot and buttocks on inspection, and quality is comparatively hard, has blush, companioned with headache around, weak.Lab testing; Find enterovirns type 71 (EV 71).After taking 2 courses for the treatment of of Chinese medicine of the present invention, clinical symptoms disappears completely, and lab testing recovers normal, non-goodbye recurrence.

Case 5

Liu so-and-so, man, 4 years old, finds on inspection to be positioned at tongue and there is vesicle two buccals, has blush around, and herpes ulceration, through being diagnosed as hand-foot-mouth disease.After taking 3 courses for the treatment of of Chinese medicine of the present invention, clinical symptoms disappears completely, and lab testing recovers normal, non-goodbye recurrence.

The above, it is only preferred embodiment of the present invention, not any pro forma restriction is done to the present invention, therefore everyly do not depart from technical solution of the present invention content, the any simple modification done above embodiment according to technical spirit of the present invention, equivalent variations and modification, all still belong in the scope of technical solution of the present invention.

Claims (7)

1. treat a Chinese medicine preparation for hand-foot-mouth disease, it is characterized in that: be made up of each component of following parts by weight:

Flos Lonicerae 2-15 part, Radix Asparagi 1-9 part, Caulis Spatholobi 1-10 part, Poria 1-5 part, Herba Violae 1-7 part, Herba Dendrobii 1-5 part, Rhizoma Osmundae 1-3 part, Radix Isatidis 1-15 part, Radix Camelliae sinensis 1-4 part, Herba Taraxaci 2-20 part, Caulis Lonicerae 2-7 part, Fructus Gardeniae 1-4 part, Radix Brassicae rapae 2-10 part, Herba Menthae 1-8 part, Herba Senecionis Scandentis 2-8 part, Flos Rosae Multiflorae 1-13 part, Folium Isatidis 2-7 part, Herba Caryopteridis Incanae 1-3 part, Fructus Momordicae 1-3 part, leaf Fructus Ligustri Lucidi 2-10 part, Fructus Forsythiae 1-7 part, Medulla Junci 1-5 part, Herba Artemisiae Scopariae 2-7 part, Periostracum Cicadae 3-6 part, Radix Caulophylli 1-4 part, Semen Coicis 2-11 part, Rhizoma Imperatae 2-6 part, Rhizoma Atractylodis 1-6 part, Radix agastaches 2-5 part, Rhizoma Kaempferiae 2-6 part, Fructus Alpiniae Oxyphyllae 2-15 part, Radix Scutellariae 2-12 part, Radix Codonopsis 1-3 part, Rhizoma Chuanxiong 2-6 part, Radix Glycyrrhizae 2-13 part, Radix Pseudostellariae 1-3 part, Fructus Mume 2-8 part.

2. a kind of Chinese medicine preparation for the treatment of hand-foot-mouth disease according to claim 1, is characterized in that: be made up of each component of following parts by weight:

Flos Lonicerae 2-10 part, Radix Asparagi 1-5 part, Caulis Spatholobi 1-8 part, Poria 1-4 part, Herba Violae 1-5 part, Herba Dendrobii 1-3 part, Rhizoma Osmundae 1-3 part, Radix Isatidis 1-10 part, Radix Camelliae sinensis 1-4 part, Herba Taraxaci 2-15 part, Caulis Lonicerae 2-7 part, Fructus Gardeniae 1-4 part, Radix Brassicae rapae 2-10 part, Herba Menthae 1-5 part, Herba Senecionis Scandentis 2-5 part, Flos Rosae Multiflorae 1-10 part, Folium Isatidis 2-7 part, Herba Caryopteridis Incanae 1-3 part, Fructus Momordicae 1-3 part, leaf Fructus Ligustri Lucidi 2-10 part, Fructus Forsythiae 1-7 part, Medulla Junci 1-5 part, Herba Artemisiae Scopariae 2-7 part, Periostracum Cicadae 3-6 part, Radix Caulophylli 1-4 part, Semen Coicis 2-8 part, Rhizoma Imperatae 2-6 part, Rhizoma Atractylodis 1-6 part, Radix agastaches 2-5 part, Rhizoma Kaempferiae 2-6 part, Fructus Alpiniae Oxyphyllae 2-10 part, Radix Scutellariae 2-10 part, Radix Codonopsis 1-3 part, Rhizoma Chuanxiong 2-6 part, Radix Glycyrrhizae 2-10 part, Radix Pseudostellariae 1-3 part, Fructus Mume 2-8 part.

3. according to a kind of Chinese medicine preparation for the treatment of hand-foot-mouth disease described in claim 1 to 2, it is characterized in that: be made up of each component of following parts by weight: Flos Lonicerae 5 parts, Radix Asparagi 1 part, Caulis Spatholobi 1 part, 1 part, Poria, Herba Violae 1 part, Herba Dendrobii 1 part, Rhizoma Osmundae 3 parts, Radix Isatidis 5 parts, Radix Camelliae sinensis 4 parts, Herba Taraxaci 6 parts, Caulis Lonicerae 2 parts, Fructus Gardeniae 1 part, Radix Brassicae rapae 2 parts, Herba Menthae 3 parts, Herba Senecionis Scandentis 2 parts, Flos Rosae Multiflorae 1 part, Folium Isatidis 2 parts, Herba Caryopteridis Incanae 1 part, Fructus Momordicae 1 part, leaf Fructus Ligustri Lucidi 2 parts, Fructus Forsythiae 1 part, Medulla Junci 1 part, Herba Artemisiae Scopariae 2 parts, Periostracum Cicadae 3 parts, Radix Caulophylli 1 part, Semen Coicis 8 parts, Rhizoma Imperatae 2 parts, Rhizoma Atractylodis 1 part, Radix agastaches 2 parts, Rhizoma Kaempferiae 2 parts, Fructus Alpiniae Oxyphyllae 5 parts, Radix Scutellariae 2 parts, Radix Codonopsis 1 part, Rhizoma Chuanxiong 2 parts, 8 parts, Radix Glycyrrhizae, Radix Pseudostellariae 1 part, Fructus Mume 5 parts.

4. a kind of Chinese medicine preparation for the treatment of hand-foot-mouth disease according to claims 1 to 3, is characterized in that: described medicament is any one dosage form described in pharmaceutics.

5. a kind of Chinese medicine preparation for the treatment of hand-foot-mouth disease according to Claims 1-4, is characterized in that: described medicament is decoction or pill.

6. a kind of Chinese medicine preparation for the treatment of hand-foot-mouth disease according to claim 1, is characterized in that: the pharmaceutical dosage form of this formula is granule, capsule, tablet or oral liquid.

7. a kind of Chinese medicine preparation for the treatment of hand-foot-mouth disease according to claim 6, is characterized in that: the preparation of described pharmaceutical dosage form comprises the steps:

(1) Flos Lonicerae, Radix Asparagi, Caulis Spatholobi, Poria, Herba Violae, Herba Dendrobii, Rhizoma Osmundae, Radix Isatidis, Radix Camelliae sinensis, Herba Taraxaci, Caulis Lonicerae, Fructus Gardeniae, Radix Brassicae rapae, Herba Menthae, Herba Senecionis Scandentis, Flos Rosae Multiflorae, Folium Isatidis, Herba Caryopteridis Incanae, Fructus Momordicae, leaf Fructus Ligustri Lucidi, Fructus Forsythiae, Medulla Junci, Herba Artemisiae Scopariae, Periostracum Cicadae, Radix Caulophylli, Semen Coicis, Rhizoma Imperatae, Rhizoma Atractylodis, Radix agastaches, Rhizoma Kaempferiae, Fructus Alpiniae Oxyphyllae, Radix Scutellariae, Radix Codonopsis, Rhizoma Chuanxiong, Radix Glycyrrhizae, Radix Pseudostellariae, Fructus Mume adds 5 ~ 20 times of soak by water three times, the each 0.5-3 hour of decocting time, collecting decoction, filter, filtrate reduced in volume becomes thick extractum, relative density is 1.25 ~ 1.30 (60 DEG C), again by thick extractum, 30 ~ 90 DEG C of drying under reduced pressure become dry extract, pulverize 200 mesh sieves and obtain extract dry extract,

(2) said extracted thing dry extract, cross 20 mesh sieves granulations, granulate, obtain dry granule;

(3) dry granule and corresponding auxiliary materials and mixing, make required dosage form.