CN102302688B - Traditional Chinese medicine used for treating influenza caused by damp toxin, and preparation method thereof - Google Patents

Abstract

The invention belongs to the field of traditional Chinese medicine, and discloses a traditional Chinese medicine used for treating influenza caused by damp toxin, and a preparation method thereof. The medicine is prepared from traditional Chinese medicine materials of, by weight: 10 to 20 parts of roughhaired holly root, 10 to 20 parts of paniculate microcos leaf, 5 to 15 parts of wrinkled gianthyssop herb, 5 to 15 parts of rhizoma crtomii, 5 to 15 parts of aphalangia, 10 to 20 parts of honeysuckle flower, 10 to 20 parts of weeping forsythia fruit, 3 to 9 parts of angelica archang lica, 5 to 15 parts of pennywort, 5 to 15 parts of indigowoad leaf, 10 to 20 parts of reed rhizome, and 3 to 9 parts of chrysanthemum flower. According to the preparation method, the traditional Chinese medicine materials are processed from two-step water extraction, and are spray-dried, such that a traditional Chinese medicine preparation is obtained. According to the invention, a traditional Chinese medicine preparation method is adopted, drug-natures of the medicines are maintained, and the formulation is reasonable. The medicine provides functions of heat clearing, detoxicating, damp dissipating, and illness removing. The medicine can be adopted for clinical use, and can be used for treating influenza caused by damp toxin. The potency and virus resistance of the medicine are good. The medicine brings no toxic or side-effect. Also, the medicine is easy to take.

Description

A kind of traditional Chinese medicine for treating damp-toxin type influenza and preparation method thereof

technical field

The invention belongs to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine for treating damp-toxin-type influenza and a preparation method thereof.

Background technique

Influenza is the abbreviation of influenza. It is an acute respiratory infectious disease caused by influenza virus. Its incidence rate ranks first among infectious diseases. Influenza", "exogenous fever", "febrile disease", and "epidemic disease". The main clinical symptoms are fever, sore throat, runny nose, stuffy nose, cough, expectoration, headache, body aches, fatigue; some cases have vomiting or diarrhea. High fever is the first and one of the most important symptoms of severe influenza, and it usually exceeds 39°C. It was first recorded in the classic of traditional Chinese medicine "Huangdi Neijing": "The five epidemics are all easily infected with each other, regardless of size, and the symptoms are similar." The prevention and treatment of plague in TCM is based on syndrome differentiation and treatment based on the clinical symptoms of patients. Therefore, regardless of whether the virus has mutated or not, the theory and practice of plague in TCM is an effective way to treat influenza. In addition, the pathogenic factors of influenza are mainly the six evils and pathogenic factors, and the pathogenic factors of dampness and heat are the common causes of exogenous diseases, and they are varied and complicated. The combined evil of the two increases the complexity and difficulty of influenza treatment. Damp evil invades the human body, blocks qi movement, stagnates meridians, and even permeates the triple burner, so it is common to feel unwell all over the body, with a heavy head like a wrap, and damp evil is often associated with other diseases. Clinically, those with severe damp-heat disease often have the syndrome of Shaoyang and Sanjiao, manifested as fluctuating cold and heat, chest fullness and abdominal distension, red urine, greasy tongue coating, etc.

So far, vaccines are still the main measures to prevent influenza epidemics. However, due to the long cycle from production to use and the variability of viruses, Western antiviral drugs are the main choice for the current prevention and control of influenza pandemics. The treatment of influenza is mostly treated with antivirals, antibiotics and glucocorticoids. Due to the variability of influenza virus, the above-mentioned medicines cannot fundamentally solve the problem of influenza. For example, for severe influenza, glucocorticoid treatment alone cannot prevent the occurrence of viral pneumonia, long-term high-dose glucocorticoid use may also cause opportunistic infections and other side effects, and increase clinical mortality. At the same time, the application of glucocorticoids will further induce Virus replication. Therefore, the research and development of a low-toxicity, high-efficiency, safe, non-drug-resistant or low-drug-resistant antiviral drug to prevent and control influenza and avoid the transformation from mild to severe and critical has received extensive attention.

Traditional Chinese medicine compound has thousands of years of experience in treating influenza, and has comprehensive effects such as inhibiting virus replication, preventing virus-induced cytopathy, regulating immune function, improving pulmonary circulation, analgesic and anti-inflammatory. Early treatment with traditional Chinese medicine can prevent the disease from progressing to severe disease, shorten the course of the disease, and have no obvious adverse reactions. Traditional Chinese medicine is effective and safe in treating influenza, and reduces the occurrence of drug-resistant strains. Therefore, traditional Chinese medicine has unique advantages and broad development prospects in the prevention and treatment of influenza, including damp-toxin-type influenza. For the treatment of damp-toxin-type influenza, the most important thing is to treat based on syndrome differentiation. Most of them focus on eliminating dampness. If dampness is eliminated, the heat will be isolated. Seep and apply. The method of removing dampness is widely used in febrile diseases. The medicines for lightening qi, sweating and relieving the lungs, and aromatic products for removing dampness reflect that the lungs control the qi of the whole body. An effective Chinese herbal compound is used to treat dampness-type influenza.

Contents of the invention

In order to solve the deficiencies in the above-mentioned prior art, the primary purpose of the present invention is to provide a traditional Chinese medicine for treating wet-toxin-type influenza.

Another object of the present invention is to provide a preparation method of the above-mentioned traditional Chinese medicine for treating damp-toxin-type influenza.

The object of the present invention is achieved through the following technical solutions: a kind of Chinese medicine for the treatment of wet-toxin-type influenza, which is prepared from the following Chinese medicine raw materials in parts by weight: 10-20 parts of Gangmeigen, cloth dregs 10-20 parts of leaves, 5-15 parts of Huoxiang, 5-15 parts of Guanzhong, 5-15 parts of mandarin orange, 10-20 parts of honeysuckle, 10-20 parts of forsythia, 3-9 parts of Angelica dahurica, 5 parts of collapsed bowl ～15 parts, 5～15 parts of Daqingye, 10～20 parts of reed root, 3～9 parts of chrysanthemum.

In order to better realize the present invention, the traditional Chinese medicine for treating damp-toxin-type influenza is prepared from the following Chinese medicine raw materials in parts by weight: 15 parts of Gangmeigen, 15 parts of Buza Ye, and 10 parts of Huoxiang , 10 parts of Guanzhong, 10 parts of mandarin orange, 15 parts of honeysuckle, 15 parts of forsythia, 5 parts of Angelica dahurica, 10 parts of big bowl, 10 parts of Daqingye, 15 parts of reed root, and 5 parts of chrysanthemum.

A method for preparing a traditional Chinese medicine for treating damp-toxin-type influenza, the method comprising the following steps: taking 10-20 parts of Prunus officinalis, 10-20 parts of Buza leaves, 5-15 parts of Huoxiang, and 5-15 parts of Guanzhong. 5-15 servings of mandarin orange, 10-20 servings of honeysuckle, 10-20 servings of forsythia, 3-9 servings of Angelica dahurica, 5-15 servings of Bengdawan, 5-15 servings of Daqingye, 10-20 servings of reed root and 3 to 9 parts of chrysanthemum, mixed with water and decocted twice, combined the medicinal juices taken out after the two decoctions, left to stand for 24 to 48 hours, filtered, and the relative density of the filtrate was 1.30 to 1.35g/cm ³ after concentration. A thick ointment with a temperature of 50-70°C; the thick ointment is spray-dried to obtain a spray-dried powder, which is further pulverized into 80-120 meshes to obtain a traditional Chinese medicine for treating wet-toxin-type influenza.

In order to better realize the present invention, the decocting by adding water twice is to mix the raw materials of traditional Chinese medicine and add 50-90°C hot water 8-12 times the total mass of the raw materials of traditional Chinese medicine, soak for 1-2 hours, then heat, time after boiling, and decoct Boil for 1-2 hours, then filter to take out the medicinal juice, then add 8-12 times the total mass of traditional Chinese medicine raw materials at 50-90°C hot water, heat and decoct, count after boiling, decoct for 1-2 hours, then filter and take out the medicinal juice.

The concentration is concentrated under reduced pressure, the conditions are pressure -0.07～-0.09Mpa, temperature 50～70°C.

The conditions of the spray drying are that the air inlet temperature is 160-180°C, and the outlet air temperature is 70-80°C.

The pharmacological effects of various raw materials of traditional Chinese medicine are as follows:

Gang Meigen: cold in nature, bitter in taste, sweet; returns to lung, liver, and large intestine meridians; clears away heat and promotes body fluid, dissipates blood stasis, detoxifies;

Cloth leaves: mild in nature, mild in taste, slightly sour; returns to the liver, spleen, and stomach meridians; clears heat and dampness, invigorates the spleen and eliminates stagnation, reduces phlegm, and reduces jaundice;

Huoxiang: slightly warm in nature, pungent in taste; returns to the spleen, stomach, and lung meridians; eliminates dampness, relieves vomiting, and relieves summer heat;

Guanzhong: slightly cold in nature, bitter and pungent in the mouth; returns to the Liver and Spleen Channels; clears heat and detoxifies, cools blood to stop bleeding, kills parasites;

Tangerine: warm in nature, pungent and bitter in taste; returns to the liver, spleen and lung meridians; dispels wind, removes phlegm, promotes qi circulation, and relieves pain;

Honeysuckle: cold in nature, sweet in taste; returns lung, heart, stomach meridian; heat-clearing and toxic substances removing, dispelling wind-heat;

Forsythia: slightly cold in nature, bitter in taste; returns to the lung, heart, and small intestine meridians; clears away heat and toxin, reduces swelling and dissipates stagnation, and dispels wind-heat;

Angelica dahurica: warm in nature, pungent in taste; returns to the lung, stomach, and large intestine meridians; relieves exterior cold, dispels wind and relieves pain, clears nasal orifices, dries dampness to stop belt, reduces swelling and expels pus;

Beng Da Wan: cold in nature, bitter and pungent in taste; returns to liver, spleen and kidney channels; clears heat and dampness, detoxifies and reduces swelling;

Folium Folium: cold in nature, bitter in taste; Guixin, Stomach Meridian; heat-clearing and toxic substances removing, cooling blood and eliminating spots;

Reed rhizome: cold in nature, sweet in taste; returns to the lung and stomach meridians; clears away heat and purging fire, promotes body fluid and quenches thirst, relieves vexation, stops vomiting, diuretic;

Flos Chrysanthemum: slightly cold in nature, pungent, sweet, and bitter in the mouth; returns lung, liver meridian; looses wind and clears away heat, calms liver and improves eyesight.

Principle of the present invention is:

The traditional Chinese medicine of the present invention aims at dampness-toxin-type influenza, grasps dampness-toxin, which is the main point of the disease, aromatizes turbidity, detoxifies and dehumidifies, and regulates the ascending and descending of the spleen and stomach, so as to dissolve existing dampness and prevent dampness that arises later. Law. And based on the principle of syndrome differentiation and treatment, the clinical therapeutic effect is good. Damp-toxin-type influenza mostly belongs to the category of "damp-warm disease" in traditional Chinese medicine. The syndrome of damp-heat is often caused by heat from dampness, heat from dampness, and heat from dampness. , the heat becomes hotter due to dampness, and the dampness and heat are cemented. In the treatment, it is especially important to eliminate dampness, so that the dampness can be eliminated, and the heat will be isolated, so that the disease will have a turning point. The evil of dampness and heat blocks the spleen and stomach in the middle energizer, resulting in abnormal ascending and descending of the spleen and stomach, and stagnation of the qi mechanism in the middle energizer. If you see uncomfortable stools, abdominal distension, and abdominal distension, the treatment is mostly with aromatherapy; In Weifen, Weiqi is stagnated, opening and closing are ineffective, and the treatment should be pungent and cool, clearing away heat and detoxifying. The way of transmission of febrile diseases is the upper reception of warm evils, first invading the lungs, and then passing back to the pericardium. The fragrance of honeysuckle and forsythia in the prescription can not only disperse wind-heat, clear away heat and detoxify, but also prevent filth and turbidity. While exposing pathogenic factors, it takes into account the characteristics of warm and heat pathogenic factors that are easy to accumulate into poison and contain dirty and turbid air, so it is used as the main medicine. Warm evil hurts people, and many Yin fluids are insufficient. Therefore, reed root sweet and cold products are used to clear away heat and relieve fire, produce body fluid and quench thirst. The characteristics of pathogens are especially suitable for those with dampness and febrile disease, severe heat and difficulty urinating. At this time, the treatment manifests clear elimination of diarrhea, focuses on promoting qi and eliminating dampness, so that the qi mechanism can be ventilated, and the water channel can be adjusted to eliminate dampness. At the same time, it contains the treatment principle of "every part of Yin fluid is preserved, and one part of vitality is preserved" for febrile diseases. Damp-heat cementation, treat with heat-clearing and damp-dispelling methods, so that dampness can be eliminated and heat can be isolated, and the gasification of the triple burner can be restored. Use Huoxiang to aromatize dampness and turbidity, stop vomiting, and the lukewarm nature does not help heat, but helps to remove dampness; Angelica dahurica aromatizes dampness, and also relieves exterior; The medicine detoxifies and avoids blast, the chrysanthemum is sweet and cold, light clear, disperses the wind and heat in the liver meridian; the five-finger mandarin orange, the cloth dregs leaves, and the plum root clear away the heat and dampness, promote the flow of qi and eliminate stagnation, and are commonly used in Guangdong herbal tea. commonly used products. The medicines used in this prescription are all clear and light products, which embodies the principle of "treating the upper Jiao Ruyu, not lightly". The invention can clear away heat and detoxify with all prescriptions, dispel dampness, transform turbidity and avoid blast, and has good preventive and therapeutic effects on damp-toxin-type influenza.

Compared with the prior art, the present invention has the following advantages and beneficial effects: the present invention is based on the theory of syndrome differentiation and treatment of traditional Chinese medicine, adopts the above-mentioned effective drug ingredients to be compatible with each other, has the effects of clearing away heat and detoxification, removing dampness and clearing blast, and achieves the treatment of dampness The purpose of influenza type influenza, and the cost is low, and the drug source is wide. The traditional Chinese medicine powder obtained by the above preparation method can be prepared into common traditional Chinese medicine preparations, such as powders, tablets, granules, capsules, etc., which are convenient to take and easily accepted by patients.

Detailed ways

The present invention will be further described in detail below in conjunction with examples, but the embodiments of the present invention are not limited thereto.

Example 1

Weigh 1500g of Gangmeigen, 1500g of Buza Ye, 1000g of Huoxiang, 1000g of Guanzhong, 1000g of Five Fingers Mandarin, 1500g of Honeysuckle, 1500g of Forsythia, 500g of Angelica dahurica, 1000g of Bengdawan, 1000g of Daqingye, 1500g of Reed Root and 500g of Chrysanthemum After mixing, add 90°C hot water that is 8 times the total mass of Chinese medicine raw materials, soak for 1 hour, heat and decoct, count the time after boiling, decoct for 1.5 hours, filter and take out the medicinal juice, and then add 90°C hot water that is 10 times the total mass of Chinese medicine raw materials , heating and decocting, timing after boiling, decocting for 2 hours, filtering out the concoction, combining the concoctions taken out, standing for 36 hours, filtering, and concentrating the filtrate under reduced pressure (pressure is -0.08Mpa, temperature is 70°C) to a density of 1.30 g/cm ³ at a temperature of 60°C, spray-dry the obtained thick paste (inlet air temperature is 170°C, and air outlet temperature is 70°C) to obtain a spray-dried powder, which is then crushed into 100 meshes and treated Traditional Chinese medicine powder for damp-toxin-type influenza. Packed according to each capsule containing 0.3g of traditional Chinese medicine powder. The patient took it orally, 3 times a day, 3 capsules each time, 3 days as a course of treatment, and after taking 1 to 3 courses of treatment, the condition would be significantly improved.

Example 2

Weigh 1000g of Gangmeigen, 1000g of Buza Ye, 500g of Huoxiang, 1500g of Guanzhong, 500g of Five Fingers Mandarin, 1000g of Honeysuckle, 1000g of Forsythia, 300g of Angelica dahurica, 500g of Bengdawan, 500g of Daqingye, 2000g of Reed Root and 900g of Chrysanthemum After mixing, add 10 times the total mass of traditional Chinese medicine raw materials in hot water at 50°C, soak for 1.5 hours, heat and decoct, count the time after boiling, decoct for 2 hours, filter and take out the medicinal juice, then add 50°C hot water that is 8 times the total mass of traditional Chinese medicine raw materials , heating and decocting, timing after boiling, decocting for 1 hour, filtering out the medicinal juice, combining the extracted medicinal juice, standing for 24 hours, filtering, and concentrating the filtrate under reduced pressure (the pressure is -0.09Mpa, the temperature is 50°C) to a density of 1.32 g/cm ³ at a temperature of 50°C, spray-dry the obtained thick paste (inlet air temperature is 160°C, and air outlet temperature is 80°C) to obtain a spray-dried powder, which is then crushed into 120 meshes and treated Traditional Chinese medicine powder for damp-toxin-type influenza. Packed according to each capsule containing 0.3g of traditional Chinese medicine powder. The patient took it orally, 3 times a day, 3 capsules each time, 3 days as a course of treatment, and after taking 1 to 3 courses of treatment, the condition would be significantly improved.

Example 3

Weigh 2000g of Gangmeigen, 2000g of Buzaye, 1500g of Huoxiang, 500g of Guanzhong, 1500g of Five Fingers Mandarin, 2000g of Honeysuckle, 2000g of Forsythia, 900g of Angelica dahurica, 1500g of Bengdawan, 1500g of Daqingye, 1000g of Reed Root and 300g of Chrysanthemum After mixing, add 12 times the total mass of Chinese medicine raw materials in hot water at 80°C, soak for 2 hours, heat and decoct, count the time after boiling, decoct for 1 hour, filter and take out the medicinal juice, then add 80°C hot water 12 times the total mass of Chinese medicine raw materials, Heating and decocting, timing after boiling, decocting for 1.5h, filtering out the medicinal juice, combining the extracted medicinal juice, standing for 32h, filtering, and concentrating the filtrate under reduced pressure (at a pressure of -0.07Mpa, at a temperature of 60°C) to a density of 1.35g/cm ³ thick paste at a temperature of 70°C, spray-dry the obtained thick paste (inlet air temperature is 180°C, and air outlet temperature is 75°C) to obtain a spray-dried powder, which is then crushed into 80 meshes to obtain Traditional Chinese medicine powder for treating dampness-type influenza. Packed according to each capsule containing 0.3g of traditional Chinese medicine powder. The patient took it orally, 3 times a day, 3 capsules each time, 3 days as a course of treatment, and after taking 1 to 3 courses of treatment, the condition would be significantly improved.

Example 4

Take the traditional Chinese medicine capsule that embodiment 1 prepares, clinical treatment wet-toxin type influenza 115 examples, all are outpatient treatment, wherein male 78 examples, female 37 examples; Aged 4～58 years old, average age 16.3 years old, wherein pharyngeal hyperemia 89 examples ( 77.4%), fever in 98 cases (85.2%), cough in 96 cases (83.5%), sore throat in 105 cases (91.3%), headache in 80 cases (69.6%), pulmonary rales in 41 cases (35.7%), expectoration 30 cases (26.1%), chills in 32 cases (27.8%). Patients take it orally, 3 times a day, 3 capsules each time, 3 days as a course of treatment, and generally patients take 1 to 3 courses of treatment. Diagnostic criteria: According to the diagnostic criteria in the "Diagnostic Protocol for Influenza A (H1N1) (3rd Edition in 2009)" revised by the Ministry of Health in October 2009. Efficacy criteria: recovery: cough, sputum and pulmonary rales disappear, body temperature is normal, increased white blood cell count and (or) neutrophil ratio return to normal, chest X-ray shows complete absorption of inflammation. Significantly effective: significantly relieved cough, sputum, normal body temperature, significantly reduced lung rales, normal white blood cell count and/or neutrophil ratio, and chest X-ray showed that most of the inflammation was absorbed. Effective: relieve cough, reduce sputum, decrease body temperature, reduce lung rales, decrease white blood cell count and/or neutrophil ratio, and chest X-ray shows that inflammation has been absorbed. Invalid: Symptoms, signs and various examinations did not change, or aggravated. The results of clinical treatment are as follows: 90 cases were cured, 12 cases were markedly effective, 7 cases were effective, and 6 cases were ineffective. The total effective rate was 94.8%.

Example 5

Clinical treatment of 4 cases of disease analysis:

1. Zhao, male, 16 years old, had a fever of 39.5°C, cough, and sore throat for 3 days, accompanied by expectoration, chills, red tongue with thin yellow coating, and rapid pulse. The patient takes the Chinese medicine capsule of the embodiment of the present invention 1, and is cured after 2 courses of treatment.

2. Qi, female, 23 years old, fever and chills, body temperature 38.5 ℃, 2 days, runny nose, sore throat, red tongue with white coating, floating and rapid pulse. The patient takes the Chinese medicine capsule of the embodiment of the present invention 2, and is cured after 1 course of treatment.

3. Chen, male, 7 years old, had fever and sore throat for 2 days, body temperature 39.8°C, obvious lung rales, headache, coughing up sputum, little amount, yellowish color, red tongue with thin white fur, rapid pulse. Children take the Chinese medicine capsule of the embodiment of the present invention 3, cure after 3 courses of treatment.

4. Wang, male, 51 years old, had fever and cough, body temperature 38.8°C, obvious lung rales, expectoration, chills, red tongue with thin white fur, floating and rapid pulse. The patient takes the Chinese medicine capsule of the embodiment of the present invention 2, and is cured after 2 courses of treatment.

The above-mentioned embodiment is a preferred embodiment of the present invention, but the embodiment of the present invention is not limited by the above-mentioned embodiment, and any other changes, modifications, substitutions, combinations, Simplifications should be equivalent replacement methods, and all are included in the protection scope of the present invention.

Claims (2)

1. A Chinese medicine for the treatment of damp-toxin-type influenza, characterized in that: the Chinese medicine is prepared from the following Chinese medicine raw materials in parts by weight: 10 to 20 parts of root plum, 10 to 20 parts of cloth dregs leaves , 5-15 parts of Huoxiang, 5-15 parts of Guanzhong, 5-15 parts of Five Fingers Orange, 10-20 parts of Honeysuckle, 10-20 parts of Forsythia, 3-9 parts of Angelica dahurica, 5-15 parts of Bengdawan, large 5-15 parts of green leaves, 10-20 parts of reed root, and 3-9 parts of chrysanthemum. 2. A kind of Chinese medicine for the treatment of wet-toxin-type influenza according to claim 1, characterized in that: the Chinese medicine is prepared from the following Chinese medicine raw materials in parts by weight: 15 parts of Gangmeigen, cloth dregs 15 parts of leaves, 10 parts of Huoxiang, 10 parts of Guanzhong, 10 parts of mandarin orange, 15 parts of honeysuckle, 15 parts of forsythia, 5 parts of Angelica dahurica, 10 parts of Bengdawan, 10 parts of Daqingye, 15 parts of reed root, chrysanthemum 5 servings. 3. The preparation method of a traditional Chinese medicine for treating damp-toxin-type influenza according to claim 1, which is characterized in that it comprises the following steps: taking 10-20 parts of Prunus officinalis root, 10-20 parts of cloth dregs leaves, Huoxiang 5 to 15 parts, 5 to 15 parts of Guanzhong, 5 to 15 parts of mandarin orange, 10 to 20 parts of honeysuckle, 10 to 20 parts of forsythia, 3 to 9 parts of Angelica dahurica, 5 to 15 parts of Beng Da Wan, 5 parts of Daqing Ye ～15 parts, 10～20 parts of reed rhizome and 3～9 parts of chrysanthemum, mix and decoct twice with water, combine the medicinal juices taken out after the two decoctions, let stand for 24～48h, filter, and obtain relative A thick ointment with a density of 1.30-1.35g/cm ³ and a temperature of 50-70°C; the thick ointment is spray-dried into powder, and then crushed to 80-120 meshes to obtain a traditional Chinese medicine for treating wet-type influenza. 4. The preparation method according to claim 3, characterized in that: adding water to decoct twice is to mix the raw materials of traditional Chinese medicine and then add hot water at 50-90°C that is 8-12 times the total mass of raw materials of traditional Chinese medicine, and soak for 1-2 hours After heating, time after boiling, decoct for 1-2 hours, filter and take out the medicinal juice, then add 50-90°C hot water 8-12 times the total mass of traditional Chinese medicine raw materials, heat and decoct, time after boiling, decoct for 1-2 hours, Then filter out the concoction. 5. The preparation method according to claim 3, characterized in that: said concentration is concentration under reduced pressure, under the conditions of pressure -0.07Mpa--0.09Mpa, temperature 50-70°C. 6. The preparation method according to claim 3, characterized in that: the conditions of the spray drying are that the air inlet temperature is 160-180°C, and the outlet air temperature is 70-80°C.