CN115998824B - Traditional Chinese medicine composition for clearing damp and detoxicating, and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for clearing damp and detoxicating, and preparation method and application thereof Download PDFInfo
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Abstract
The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for clearing damp and removing toxin, which comprises the following main active components in parts by mass: 10-20 parts of radix bupleuri, 10-20 parts of radix clematidis, 10-20 parts of patchouli, 20-40 parts of semen coicis, 10-20 parts of perilla stem, 15-20 parts of perilla leaf and 5-15 parts of rhizoma atractylodis. The traditional Chinese medicine composition for clearing damp and detoxicating provided by the invention has the effects of relieving exterior syndrome and eliminating dampness, strengthening spleen and detoxifying, can clear heat generated by exterior syndrome and spleen toxin, has proper force of resolving dampness toxin and resolving heat of depression, can be effectively used for treating symptoms such as fever, light and heavy trend, dizziness, heavy and lassitude, chest distress and desire to vomit, inappetence, loose stool, yellow and greasy tongue fur, floating and slippery pulse and the like after novel coronavirus infection, and can avoid the disadvantages of body fluid loss or cold depression.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for clearing damp and removing toxin and application thereof.
Background
At present, new coronaviruses are still continuously mutated, and since the epidemic of the Omikovia strain, the infectious power of the viruses is enhanced, but the pathogenicity is gradually weakened, and the clinical symptoms of most infected people are mainly the upper respiratory tract symptoms and the digestive tract symptoms.
In the prevention and treatment process of the novel coronavirus, the traditional Chinese medicine shows remarkable advantages. In the current novel diagnosis and treatment scheme for coronavirus infection, aiming at the treatise on damp toxin, the cold-dampness stagnation lung syndrome, damp-heat stagnation lung syndrome, and cold-dampness stagnation lung syndrome are arranged, and the treatment is mainly performed by dispersing lung qi and eliminating pathogenic factors, warming and resolving cold dampness, aromatic dampness, clearing heat and detoxicating, resolving phlegm and removing dampness, dispersing lung qi and eliminating pathogenic factors, aromatic dampness, or strong force of drying dampness, or strong force of clearing heat. However, the applicant researches find that for patients who show symptoms such as fever, dizziness, heavy body, listlessness, chest distress, vomiting, inappetence, loose stool, yellow and greasy tongue coating, and superficial and slippery pulse after infection by the novel coronavirus, the current treatment scheme has the disadvantages of easily damaging body fluids, consuming fluid, or cold and cool stagnation because of excessive cold and cool and easy accumulation of ice and pathogenic factors or excessive warm and dry and easy consumption of body fluids.
Therefore, a novel traditional Chinese medicine composition for treating coronavirus infection with syndrome of damp toxin and heat is still lacking at present.
Disclosure of Invention
The first aim of the invention is to provide a traditional Chinese medicine composition for clearing damp and removing toxin, which aims to solve at least one of the technical problems.
The second object of the present invention is to provide a preparation method of the traditional Chinese medicine composition, so as to solve at least one of the above technical problems.
The third object of the present invention is to provide an application of the traditional Chinese medicine composition, so as to solve at least one of the above technical problems.
According to one aspect of the invention, a traditional Chinese medicine composition for clearing damp and removing toxin is provided, and the main active ingredients of the traditional Chinese medicine composition comprise, by mass: 10-20 parts of radix bupleuri, 10-20 parts of radix clematidis, 10-20 parts of patchouli, 20-40 parts of semen coicis, 10-20 parts of perilla stem, 15-20 parts of perilla leaf and 5-15 parts of rhizoma atractylodis.
The disease is affected by damp toxin, the pathogenic factors of the damp toxin are stagnated for transforming heat, but the heat potential is not obvious, so the disease is feverish and serious in the twilight of the twilight; the damp heavy turbidity is sticky, and the clear yang is blocked, so that the clear yang is not dispersed, and dizziness is caused; dampness is attached to the limbs of the muscles, thus the body is heavy and tired; the damp-retention in the middle energizer and the dysfunction of transportation and transformation in the chest lead to chest distress, vomiting, inappetence and loose stool; the tongue coating is yellow and greasy, and the pulse is superficial and slippery, which is the condition of damp-toxin resolving heat. Based on the above, the invention takes the methods of relieving exterior syndrome and eliminating dampness and strengthening spleen and detoxifying as the prescription, provides the traditional Chinese medicine composition with the effects of relieving exterior syndrome and eliminating dampness and detoxifying, which can relieve exterior syndrome and damp toxin in spleen, clear heat caused by long-term depression, has proper strength of relieving damp toxin and clearing heat of depression, can be effectively used for treating patients with symptoms of fever, light and heavy afterward, dizziness and distention, heavy body and lassitude, chest distress and vomiting, inappetence, loose stool, yellow and greasy tongue fur, floating and slippery pulse and the like caused by damp toxin and heat syndrome after novel coronavirus infection, and can avoid the disadvantages of fluid loss or cold and cool depression.
In the formula of the invention, the bupleurum is bitter and pungent and slightly cold, and has the effects of relieving exterior syndrome and bringing down fever, and the smell of the bupleurum is light, clear, aromatic and free, so as to eliminate pathogenic factors, and the bupleurum is still separated from the exterior syndrome (materia medica sense); herba Pogostemonis, with pungent and warm nature, can relieve exterior syndrome, dispel damp-toxin, and harmonize spleen and stomach, is fragrant but not violent, warms up but not prone to dryness-heat, can dispel haze damp evil, helps spleen and stomach healthy qi, is a drug for damp-obstruction of spleen yang, is tiredness and powerless, is not sweet in taste, and has the most rapid effect on turbid and dirty tongue coating (Ben Cao Zheng Yi), and is a monarch drug together with cold and warm nature, and can dispel damp-toxin evil, and relieve exterior syndrome and defervesce. Radix Clematidis can dispel wind and remove dampness, takes scurrying and eliminating dampness as the energy thing, accumulates dampness and stops phlegm, and coagulates qi stagnation, is suitable for various purposes (materia medica sense), coix seed Gan Danjian spleen, and has the effects of clearing heat and promoting diuresis as ministerial drugs, and can help patchouli to strengthen the effect of dispelling dampness; perillae She Yi is used as ministerial drug for assisting in enhancing the exterior syndrome relieving effect of bupleurum. Perilla stem and rhizoma Atractylodis are used as adjuvant and guiding drugs, and they both enter spleen and stomach meridians, so that the perilla stem' governs the middle energizer to promote qi circulation, dispel food and phlegm and saliva. For dysphagia and regurgitation ("Ben Cao Chong Yu" in the body of materia), rhizoma Atractylodis is used for drying dampness and strengthening spleen, "dampness and affecting spleen yang, listlessness and lying on the stomach, soreness and weakness of limbs, fullness and stuffiness of chest and diaphragm, even distention of the diaphragm and thick and greasy tongue, the non-Mao Zhu is strong in fragrance and can not release, and phlegm and fluid are diffused and not transformed (Ben Cao Zhengyi) and the two are mutually matched, so that the Chinese herbal medicine can not only promote qi due to stagnation of middle-jiao but also resolve phlegm and food stagnation. The medicines are combined to play the roles of relieving exterior syndrome, resolving dampness, strengthening spleen and detoxifying.
In the recipe, the cold of bupleurum and coix seed is slightly cold, which is sufficient to clear the heat of stasis without the disadvantage of cold inhibition; herba Agastaches, radix Clematidis, folium Perillae, caulis Perillae, and rhizoma Atractylodis are warm, aromatic, warm and dry without being in the middle of violent, and both are suitable for treating symptoms such as fever, dizziness, heavy and tired body, chest distress, emesis, inappetence, loose stool, yellow and greasy tongue fur, and floating and slippery pulse, which are manifested by damp toxin-resolving heat syndrome.
In some embodiments, the traditional Chinese medicine composition for clearing damp and removing toxin comprises the following main active ingredients in parts by mass: 15 parts of bupleurum, 15 parts of radix clematidis, 15 parts of patchouli, 30 parts of coix seed, 15 parts of perilla stem, 15 parts of perilla leaf and 10 parts of rhizoma atractylodis.
The traditional Chinese medicine composition for dispelling dampness and detoxifying is mainly used for treating symptoms such as fever, slight and heavy twiddle, dizziness, heavy fatigue, chest distress and desire to vomit, inappetence, loose stool, yellow and greasy tongue fur, floating and slippery pulse and the like after novel coronavirus infection.
The sources of the raw materials of the method are as follows:
Bupleurum root: is dry root of Bupleurum Bupleurum chinensie DC or Bupleurum scorzonerifolium Bupleurum scorzonerifolium Willd. Pungent and bitter in flavor and slightly cold in nature; it enters liver, gallbladder and lung meridians.
Radix Clematidis: is dried root and rhizome of Clematis chinensis CLEMATIS CHINENSIS Osbeck, clematis chinensis Clematis hexapetala pall, or Clematis chinensis Clematis manshurica rupr. Pungent and salty taste, warm nature; enter bladder meridian.
Herba Pogostemonis: is aerial part of patchouli Pogostemon cablin (Blanco) benth of genus patchouli of family Labiatae. Pungent taste and slightly warm nature; enter spleen, stomach and lung meridians.
Semen Coicis: is a dried mature kernel of Coix lacryma-jobi Coix lacryma jobi L.var.mayue (Roman.) Stapf belonging to genus Coix of family Gramineae. Sweet and light in taste and cool in nature; enter spleen, stomach and lung meridians.
Perilla stem: is stem of Labiatae Perilla plant Perilla Perilla frutescens (L.) Britt.var.arguta (benth.) hand. -Mazz. Or Perilla frutescens (L.) Britt.var.purpsuracens (Hayata) H.W.Li. Pungent taste and warm nature; enter spleen, stomach and lung meridians.
Perilla leaf: leaves or tender branch leaves of the Labiatae Perilla genus plant Perilla Perilla frutescens (L.) Britt.var arguta (benth.) hand. -Mazz. And Perilla frutescens (L.) Britt.var.purplaservice (Hayata) H.W.Li [ P.frexecens (L.) Britt.var.acuta (thunder.) Kudo ]. Pungent taste and warm nature; enter lung, spleen and stomach meridians.
Rhizoma atractylodis: is dried rhizome of Atractylodes lancea Atractylodes lancea (thunder.) DC or Atractylodes lancea Atractylodes chinensis (DC.) Koidz. Pungent and bitter in taste and warm in nature; it enters spleen, stomach and liver meridians.
In some embodiments, the dosage form of the traditional Chinese medicine composition can be decoction, tablets, capsules, granules, oral liquid or powder.
In some embodiments, pharmaceutically acceptable excipients, such as sustained release agents, excipients, fillers, binders, wetting agents, disintegrants, absorption enhancers, adsorption carriers, surfactants, lubricants, and the like, are also included.
When the Chinese medicinal composition is decoction, the preparation method can comprise the following steps:
Mixing the raw materials according to a proportion, adding 8-12 times of water by weight for soaking for 20-40 minutes, then decocting for 1-2 hours, filtering, repeatedly decocting filter residues for 1-2 times, and combining the filtrates to obtain the traditional Chinese medicine. The filtrate can be packaged after cooling, thereby being convenient to carry and distribute.
When in powder form, the preparation method can comprise the following steps:
Respectively pulverizing or shredding the raw materials, sieving the pulverized or shredded raw materials with 10 mesh and 50 mesh sieve, continuously pulverizing or shredding coarse particles which cannot pass through the 10 mesh sieve, taking powder between the 10 mesh sieve and the 50 mesh sieve, uniformly mixing the raw material powder according to a proportion, filling into a sealing bag, and sealing.
In the case of other dosage forms such as tablets, capsules, granules and the like, the preparation method can comprise the following steps:
Mixing the raw materials according to a proportion to prepare extract (each 1g of extract is equivalent to 2-5g of the raw materials), adding auxiliary materials, and preparing corresponding dosage forms according to a traditional Chinese medicine conventional preparation process.
Clinical research results show that the traditional Chinese medicine composition provided by the invention can well improve symptoms of fever, heaviness of head and body, nausea, inappetence, stool rot and the like of patients, and can be used for preparing medicines for treating novel coronavirus infection, in particular medicines for treating patients suffering from novel coronavirus infection with syndrome of damp-toxin heat.
Detailed Description
The present invention will be described in further detail with reference to specific examples. The raw materials and reagents used in the present invention are commercially available unless otherwise specified.
Example 1
The traditional Chinese medicine decoction for clearing damp and removing toxin of the embodiment is prepared from the following raw medicinal materials in average dose (about 200 mL): 15 g of bupleurum, 15 g of radix clematidis, 15 g of patchouli, 30g of coix seed, 15 g of perilla stem, 15 g of perilla leaf and 10g of rhizoma atractylodis.
The preparation method comprises the following steps:
Mixing the raw materials according to a certain proportion, soaking in 10 times of water for 30min, heating to boil, keeping micro boiling for 1 hr, and filtering to obtain a first decoction and residue; adding water 8 times of the total weight of the raw materials into the residue obtained after the first decoction, heating to boil, keeping micro-boiling for 1 hour, and separating to obtain a second decoction and residue; and combining the first decoction and the second decoction.
In order to verify the treatment effect of the traditional Chinese medicine composition, the invention develops clinical researches by taking the dampness-dispelling and toxin-removing decoction prepared in the embodiment 1 of the invention as a test medicine, and the research process and the result are as follows:
1. Correlation standard
1.1 Diagnostic criteria
1.1.1 Western medicine disease diagnosis
With reference to the new coronavirus infection diagnosis and treatment protocol (ninth edition of trial), there is epidemiological history and clinical manifestation, which accords with etiology evidence (new coronavirus nucleic acid detection positive or antigen detection positive).
Disease typing refers to the novel diagnosis and treatment scheme for coronavirus infection (ninth edition of trial) and is classified into light, common, heavy and dangerous.
1.1.2 Criteria for diagnosis of waiting for Chinese medical Condition
Syndrome of damp toxin resolving heat: fever, heavy twilight, dizziness, heavy lassitude, chest distress, vomiting, inappetence, loose stool, yellow and greasy tongue coating, and superficial and slippery pulse.
1.2 Inclusion criteria
(1) Detecting positive for the novel coronal nucleic acid or antigen;
(2) The classification standard of the novel coronavirus infection diagnosis and treatment scheme (trial ninth edition) is referred to, and the method belongs to light people.
(3) Age 18-65 years (including boundary values);
(4) Signing the informed consent.
Exclusion criteria:
(1) Acute origins of severe basal diseases or chronic diseases, such as acute heart failure, are combined.
(2) Female subjects during pregnancy, lactation or lactation;
(3) The disease affecting the duration of symptoms such as bronchopneumonia, chronic lung abscess, chronic cough for more than 8 weeks, chronic pharyngolaryngitis and cough.
3. Case withdrawal and shedding
Case withdrawal and abscission refers to cases where patients are not willing to continue to participate in clinical trials during the course of the study after entering the group or are unable to complete the full course of treatment as prescribed.
Treatment of withdrawn and exfoliated cases: the researcher should contact the subject by home visit, telephone, letter and the like, record the last treatment time and complete the completed evaluation project. And knows the reason for its exit, as recorded in the case report form. The observation data of all the withdrawn and fallen cases are reserved.
2. Case origin: a new light case of coronavirus infection diagnosed at the febrile clinic in the middle of Guangdong province during the study period.
3. Intervention and grouping:
All patients who incorporate the dampness-dispelling and toxin-removing prescription take 200mL of the dampness-dispelling and toxin-removing prescription decoction prepared in the embodiment 1, 1 dose per day, and 2 times a day, 100mL of the dampness-dispelling and toxin-removing prescription decoction is taken each time, and the median treatment course is 5 days.
All patients are treated according to the novel pneumonia diagnosis and treatment scheme (trial ninth edition) of coronavirus infection after entering the group, so that the basic treatment of the patients is ensured, but the antiviral treatment is not carried out.
4. Statistical methods:
The measurement data is subjected to normal test, and accords with normal average number +/-standard deviation description, normal distribution using median and quarter bit description, curative effect is successively compared, normal distribution data is subjected to paired t test, and non-normal distribution data is subjected to non-parameter test. The counting data is checked by using a chi-square.
5. Test results
1. Baseline analysis
Baseline data for the patients are shown in table 1:
Table 1 baseline profile for patients
As shown in table 1, the two groups of gender distribution are balanced, and compared with the control group without taking the decoction of the invention, the patients of the formula of the invention have older ages; the control group uses more combined medicines, especially cough relieving and phlegm reducing medicines.
2. The symptoms of the patient at the time of onset are shown in Table 2
TABLE 2 patient's onset symptoms form
| Symptoms (n,%) | Control group (n=47) | Dampness eliminating and detoxifying square set (n=37) |
| Heating up | 38(80.8) | 24(64.8) |
| Cough with cough | 44(93.6) | 32(86.4) |
| Nasal obstruction or runny nose | 33(70.2) | 16(43.2) |
| Sore throat | 36(76.5) | 16(43.2) |
| Muscle pain | 29(61.7) | 12(32.4) |
| Headache pain | 24(51.0) | 12(32.4) |
| Tired | 36(76.5) | 13(35.1) |
| Aversion to cold or chills | 27(57.4) | 11(29.7) |
| Dysgeusia | 14(29.7) | 7(18.9) |
| Abnormal smell sense | 11(23.4) | 3(8.10) |
| Shortness of breath or dyspnea | 23(48.9) | 0(0) |
| Diarrhea (diarrhea) | 13(27.6) | 3(8.10) |
| Nausea of | 13(27.6) | 2(5.40) |
| Vomiting of vomiting | 5(10.6) | 3(8.10) |
As shown in table 2, the top four symptoms of the dampness-dispelling and detoxifying formula group were fever, cough, nasal obstruction/nasal discharge and sore throat; the highest symptom of the formula with the highest proportion is cough, the proportion is 86.4 percent, and the symptom predominance is that the second symptom generates heat (64.8 percent).
3. Symptom disappearance condition table after patient uses medicine
Table 3 patient symptom disappearance evaluation scale
As shown in table 3, the dampness-dispelling and toxin-removing prescription has better effect of relieving nasal obstruction/running nose, cough, cold feeling and chills; the effect of relieving fever and gustatory abnormality was also superior to that of the control group.
4. Symptom disappearance schedule after administration of the drug to the patient
TABLE 4 evaluation of time to disappearance of symptoms in patients
| Symptom vanishing time (day, IQR) | Control group (n=47) | Dampness eliminating and detoxifying square set (n=37) | P value |
| Heating up | 4(3-5) | 2(2-3) | 0.008 |
| Nasal obstruction or runny nose | 5.5(3.25-8.5) | 4(3-7) | 0.553 |
| Sore throat | 4.5(3.75-7.75) | 4(2.75-5) | 0.248 |
| Shortness of breath or dyspnea | 6(6-6) | - | - |
| Cough with cough | 4(2.5-10.5) | 7(4.25-8.75) | 0.36 |
| Tired | 7.5(3.75-10.5) | 2(1.25-5.75) | 0.081 |
| Muscle pain | 5(2-6.5) | 2(1-3) | 0.085 |
| Headache pain | 4.5(2.75-5.25) | 2(1-2.5) | 0.016 |
| Aversion to cold or chills | 5(1-6) | 2(2-4.25) | 0.541 |
| Nausea of | - | 1(1-1) | - |
| Vomiting of vomiting | 3(3-3) | 1(1-1) | 0.157 |
| Diarrhea (diarrhea) | 3(2.25-7.5) | 2(2-2) | 0.264 |
| Abnormal smell sense | - | 4(1-7) | - |
| Dysgeusia | - | 3(1-6.25) | - |
As shown in table 4, the dampness-dispelling and detoxifying formula significantly shortened the fever time and headache duration of the patients relative to the control group.
5. Residual symptom table after treatment of patient
Table 5 table of residual symptoms after patient treatment
| Symptoms (n,%) | Control group (n=47) | Dampness eliminating and detoxifying square set (n=37) |
| Cough with cough | 37(78.7) | 17(45.9) |
| Nasal obstruction or runny nose | 23(48.9) | 5(13.5) |
| Sore throat | 11(23.4) | 6(16.2) |
| Tired | 23(48.9) | 10(27.0) |
| Dysgeusia | 16(34.0) | 1(2.7) |
| Headache pain | 7(14.8) | 2(5.4) |
| Abnormal smell sense | 13(27.6) | 1(2.7) |
| Shortness of breath or dyspnea | 15(31.9) | 2(5.4) |
| Muscle pain | 11(23.4) | 2(5.4) |
| Diarrhea (diarrhea) | 3(6.4) | 0(0) |
| Heating up | 6(12.7) | 0(0) |
| Aversion to cold or chills | 15(31.9) | 0(0) |
| Nausea of | 5(10.6) | 1(2.7) |
| Vomiting of vomiting | 0(0) | 1(2.7) |
As shown in Table 5, the main residual symptoms after treatment of the formula for eliminating dampness and detoxifying are cough, the control group accounts for 78.7%, the formula for eliminating dampness and detoxifying accounts for 45.9%, and the symptoms except for cough, nasal obstruction, nasal discharge, sore throat and tiredness of each group after treatment account for less than 10%.
6. Conclusion:
(1) After the medicine is taken for 5 days, the symptoms of the patients are obviously improved, and the difference has statistical significance.
(2) The dampness-dispelling and toxin-removing prescription can obviously relieve the symptoms of cough and the like of patients and obviously shorten the disappearance time of various symptoms.
What has been described above is merely some embodiments of the present invention. It will be apparent to those skilled in the art that various modifications and improvements can be made without departing from the spirit of the invention.
Claims (7)
1. A traditional Chinese medicine composition for treating damp-toxin heat syndrome type novel coronavirus infection is characterized by comprising the following raw materials in parts by mass: 10-20 parts of radix bupleuri, 10-20 parts of radix clematidis, 10-20 parts of patchouli, 20-40 parts of semen coicis, 10-20 parts of perilla stem, 15-20 parts of perilla leaf and 5-15 parts of rhizoma atractylodis.
2. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by mass: 15 parts of bupleurum, 15 parts of radix clematidis, 15 parts of patchouli, 30 parts of coix seed, 15 parts of perilla stem, 15 parts of perilla leaf and 10 parts of rhizoma atractylodis.
3. The traditional Chinese medicine composition according to claim 1 or 2, wherein the traditional Chinese medicine composition is in the form of decoction, tablets, capsules, granules, oral liquid or powder.
4. The traditional Chinese medicine composition according to claim 3, further comprising pharmaceutically acceptable excipients.
5. The composition of claim 4, wherein the pharmaceutically acceptable excipients are selected from at least one of slow release agents, excipients, fillers, binders, wetting agents, disintegrants, absorption promoters, adsorption carriers, surfactants, lubricants.
6. The method for preparing the traditional Chinese medicine composition according to claim 3, wherein when the traditional Chinese medicine composition is a decoction, the method for preparing the traditional Chinese medicine composition comprises the following steps:
mixing the raw materials according to a proportion, adding 8-12 times of water by weight for soaking for 20-40 minutes, then decocting for 1-2 hours, filtering, repeatedly decocting filter residues for 1-2 times, and combining the filtrates to obtain the traditional Chinese medicine.
7. The use of a Chinese medicinal composition according to any one of claims 1-5 in the manufacture of a medicament for the treatment of a novel coronavirus infection with damp-toxin heat syndrome.
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| CN111407808A (en) * | 2020-02-26 | 2020-07-14 | 江苏省中医院 | Epidemic-resistant traditional Chinese medicine composition, preparation method and pharmaceutical application thereof |
| CN111920938A (en) * | 2020-10-15 | 2020-11-13 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | Bupleurum root antidote drug composition and preparation method and application thereof |
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| CN111317798A (en) * | 2020-04-16 | 2020-06-23 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | Traditional Chinese medicine composition for detoxifying, eliminating dampness and relieving sore throat and application thereof |
| CN111920938A (en) * | 2020-10-15 | 2020-11-13 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | Bupleurum root antidote drug composition and preparation method and application thereof |
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