CN111773302A - Traditional Chinese medicine composition for treating severe new coronary pneumonia and preparation and application thereof - Google Patents
Traditional Chinese medicine composition for treating severe new coronary pneumonia and preparation and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating severe new coronary pneumonia and a preparation method and application thereof, wherein the composition is prepared from the following raw materials in parts by mass: 10-20 parts of semen lepidii, 5-20 parts of snakegourd peel, 10-30 parts of wild buckwheat root, 10-30 parts of pulmonanthus japonicus, 10-30 parts of fried scutellaria baicalensis, 5-20 parts of perillaseed, 10-20 parts of allium macrostemon head, 10-20 parts of ginger processed pinellia tuber, 5-30 parts of cassia twig, 10-30 parts of raw white paeony root, 10-30 parts of ligusticum wallichii and 10-30 parts of semen brassicae. The traditional Chinese medicine composition obviously improves respiratory symptoms, shortens the isolation days and reduces the incidence rate of critical illness. The traditional Chinese medicine composition is a medicine formula selected by taking heat clearing and phlegm reducing as a treatment principle under the guidance of the theory of traditional Chinese medicine, has no obvious toxic or side effect in treatment of the traditional Chinese medicine, can be taken for a long time, and has a wide application range.
Description
(I) technical field
The invention relates to a traditional Chinese medicine composition for treating severe new coronary pneumonia and preparation and application thereof.
(II) background of the invention
Since 12 months in 2019, only six kinds of coronavirus which can infect human are known, wherein only two kinds of SARS-CoV and MERS-CoV can kill pneumonia together, and the other four kinds of HcoV-229E, HcoV-NL63, HcoV-HKU1 and HcoV-OC43 coronavirus can only cause mild respiratory tract infection. This new coronavirus pneumonia seems to cause symptoms similar to SARS, and a recent clinical study from china released by Lancet showed that 41 patients with 2019-nCoV infection who had been diagnosed in the laboratory, 1/3 needed intensive care, 6 deaths, and 5 patients with acute cardiac injury, and the latter study of concurrent epidemics reported clinical and microbiological data from six families, confirming the possibility of interpersonal spread. As 24 days, 2 months and 1 day, 14380 confirmed cases, 2110 current severe cases, 304 death cases and 328 cured and discharged hospitals are reported in a cumulative way. The situation of epidemic is severe, the transmission path is unknown at present, no specific therapeutic medicine is available, and in view of the actual combat experience during SARS epidemic period in 2003, the unique advantages of the traditional Chinese medicine in the process of epidemic prevention and treatment need to be brought into play at present.
Respiratory tract infection caused by the respiratory tract virus has the characteristics of seasonality, epidemic, infectivity and the like, and the respiratory tract infection belongs to the category of warm diseases in traditional Chinese medicine, and can be called as exhaling according to different seasons such as wet temperature, spring temperature, wind temperature, winter temperature and the like. In thousands of years of clinical practice, ancient physicians accumulated valuable experience in the treatment of seasonal disorders. As early as in Su Wen & Ci Fang Lun, we propose to avoid its toxic pathogen. Emphasizes the idea that the pestilence needs to be prevented before the disease is caused, and inspires the epidemic prevention nowadays. The "Shanghai treatise on the clinical experience of ancient physicians in treating the acute infectious disease" Shanghai "represented by Zhang Zhongjing was recorded in the Shanghai treatise on the typhoid. The prescriptions of ephedra decoction, small bupleurum decoction, large chengqi decoction, white tiger decoction, Sini decoction and the like are always the main prescriptions for treating seasonal infectious diseases by the later-aged doctors. In the period of Song Jinyuan and in the beginning of Ming dynasty, the pestilence in China is rampant, doctors and families use the classics in the Shang Han Lun, and the doctors and the families have innovation in combination with clinical practice, thereby creating the epidemic febrile disease and making a lot of contribution which cannot be killed.
The pathogenesis of the disease is that pathogenic factors of pestilence enter from mouth to nose, firstly invade the lung, the lung qi is damaged, and the lung qi fails to clear and descend, so that cough, dispersion and descent disorder, dyspnea and tachypnea, chest distress and dyspnea occur. Epidemic toxin obstructing the lung is the most common syndrome type in severe patients, the disease progresses rapidly, and the first important meaning of eliminating damp-heat and epidemic toxin and promoting qi circulation is the main meaning in treatment, and the key points of reducing the severe condition and reducing the fatality rate are realized.
Disclosure of the invention
Aiming at the pathogenesis characteristic of severe new coronary pneumonia, the traditional Chinese medicine composition capable of definitely improving the disease is screened from the traditional Chinese medicine raw materials through reasonable proportioning and synergistic action of all medicinal materials under the guidance of the traditional Chinese medicine theory, and the traditional Chinese medicine oral preparation which can help and treat patients with the novel coronary pneumonia, quickens the conversion of severe patients into mild diseases, reduces complications and fatality rate and has no toxic or side effect is prepared, is suitable for being taken by people and has definite effect on the common type of treating the new coronary pneumonia.
The technical scheme adopted by the invention is as follows:
the invention provides a traditional Chinese medicine composition for treating severe new coronary pneumonia, which is prepared from the following raw materials in parts by mass: 10-20 parts of semen lepidii, 5-20 parts of snakegourd peel, 10-30 parts of wild buckwheat root, 10-30 parts of pulmonanthus japonicus, 10-30 parts of fried scutellaria baicalensis, 5-20 parts of perillaseed, 10-20 parts of allium macrostemon head, 10-20 parts of ginger processed pinellia tuber, 5-30 parts of cassia twig, 10-30 parts of raw white paeony root, 10-30 parts of ligusticum wallichii and 5-30 parts of semen brassicae.
Further, preferably, the traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 15 parts of semen lepidii, 9 parts of trichosanthes peel, 30 parts of wild buckwheat root, 30 parts of pulmonanthus, 30 parts of fried scutellaria baicalensis, 9 parts of perillaseed, 12 parts of allium macrostemon head, 12 parts of rhizoma pinelliae preparata, 9 parts of cassia twig, 15 parts of raw white paeony root, 15 parts of ligusticum wallichii and 9 parts of brassica alba boiss.
Further, the composition also comprises a pharmaceutically acceptable carrier to prepare decoction, granules and oral liquid which are well known in the art, and the decoction is preferred.
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps: weighing semen Lepidii, pericarpium Trichosanthis, radix Fagopyri Esculenti, herba Euphorbiae Lunulatae, parched Scutellariae radix, fructus Perillae, Bulbus Allii Macrostemi, ginger processed pinellia Tuber, ramulus Cinnamomi, radix Paeoniae alba, rhizoma Ligustici Chuanxiong, and semen Sinapis Albae according to formula amount, adding 5 times of water, soaking for 1 hr, heating and decocting for 20 min, boiling, and filtering; and adding 3 times of water into the medicine residues, heating to boil, filtering after boiling, combining the filtrates, and concentrating until the density is 1.02-1.2 to obtain decoction.
The invention also relates to application of the traditional Chinese medicine composition in preparing a medicine for treating severe new coronary pneumonia.
The severe new coronary pneumonia meets any one of the following conditions: 1. respiratory distress, RR is more than or equal to 30 times/minute; 2. under the resting state, the oxygen saturation is less than or equal to 93 percent; the partial pressure of oxygen in arterial blood/oxygen concentration is less than or equal to 300 mmHg.
The invention relates to a common traditional Chinese medicine composition for treating neocoronary pneumonia, which is prepared from semen lepidii, pericarpium trichosanthis, wild buckwheat root, pulmonanthus, fried scutellaria baicalensis, perilla fruit, allium macrostemon head, ginger processed pinellia ternate, cassia twig, raw white paeony root, ligusticum wallichii and white mustard seed. Semen Lepidii purges lung water and promotes lung qi; the tartary buckwheat root has the effects of clearing away heat and toxic materials, relieving cough, relieving asthma and eliminating phlegm; pericarpium Trichosanthis, semen Sinapis Albae, and fructus Perillae for resolving phlegm; ramulus Cinnamomi and Bulbus Allii Macrostemi are pungent, bitter and warm in flavor, and have strong effects of activating yang and promoting qi circulation; pinellia ternate helps snakegourd fruit and allium macrostemon to activate yang and dissipate stagnation, and dispel phlegm and widen chest; the pulicaria and the fried scutellaria root clear lung heat; radix Paeoniae alba has effects of dispelling pathogenic wind and calming liver; rhizoma Ligustici Chuanxiong has effects of dispelling pathogenic wind, promoting blood circulation and removing blood stasis; the medicines are compatible, and have the effects of clearing away heat and toxic materials, eliminating phlegm and relieving cough and asthma.
Compared with the prior art, the invention has the following beneficial effects: the traditional Chinese medicine composition obviously improves respiratory symptoms, shortens the isolation days and reduces the incidence rate of critical illness. The traditional Chinese medicine composition is a medicine formula selected by taking heat clearing and phlegm reducing as a treatment principle under the guidance of the theory of traditional Chinese medicine, has no obvious toxic or side effect in treatment of the traditional Chinese medicine, can be taken for a long time, and has a wide application range.
(IV) detailed description of the preferred embodiments
The invention will be further described with reference to specific examples, but the scope of the invention is not limited thereto:
the raw materials used in the embodiment of the invention are all collected and prepared according to the 'Chinese pharmacopoeia' 2015 edition.
EXAMPLE 1 Chinese medicinal composition
1. The formula is as follows: the traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 15 parts of semen lepidii, 9 parts of snakegourd peel, 30 parts of wild buckwheat root, 30 parts of pulmonanthus, 30 parts of fried scutellaria baicalensis, 9 parts of perillaseed, 12 parts of allium macrostemon head, 12 parts of ginger processed pinellia tuber, 9 parts of cassia twig, 15 parts of raw white paeony root, 15 parts of ligusticum wallichii and 9 parts of brassica alba boiss.
2. Preparation:
weighing 15g of semen lepidii, 9g of snakegourd peel, 30g of tartarian buckwheat root, 30g of pulmonanthus, 30g of fried scutellaria baicalensis, 9g of perilla fruit, 12g of allium macrostemon head, 12g of ginger processed pinellia tuber, 9g of cassia twig, 15g of raw white paeony root, 15g of ligusticum wallichii and 9g of white mustard seed according to the formula amount; adding water 5 times the total weight of the medicinal materials, soaking for 1 hour, heating and decocting for 20 minutes, boiling and filtering; and adding 3 times of water into the decoction dregs, heating to boil, filtering after boiling, combining the filtrates, and concentrating until the density is 1.02-1.2 to obtain decoction.
Example 2 clinical observations of the Chinese medicinal composition of the invention for treating severe New coronary pneumonia
12 patients were from the Wenzhou Central Hospital. The research adopts a queue research method, mainly observes the case evaluation curative effect summary, and observes the patient condition. Dividing into a control group and an observation group according to whether the patients take the traditional Chinese medicine orally or not, naturally grouping according to the clinical treatment condition, and not limiting the number of each group.
Inclusion criteria were: firstly, a patient with the novel coronavirus pneumonia is diagnosed; secondly, clinical typing belongs to severe pneumonia caused by the novel coronavirus; age 18-85 years old; fourthly, the informed consent is signed.
Exclusion criteria: firstly, patients with relatively serious primary diseases such as heart, lung, liver, kidney, brain, hematopoietic system and the like are combined; ② pregnant or lactating women; ③ psychiatric patients; and fourthly, the Chinese herbal medicines are participating in other clinical testers or taking other Chinese herbal medicines.
The method comprises the following steps: whether to apply the traditional Chinese medicine treatment is determined according to the will of a patient, and the traditional Chinese medicine treatment is divided into a control group and an observation group according to the application condition of the traditional Chinese medicine.
Control group: conventional Western medicine treatment (trial run fifth edition of 'diagnosis and treatment plan for pneumonia infected by novel coronavirus' issued by State Wei Jian Wei and State administration of management)
Observation group: for patients with severe type of novel coronavirus pneumonia, decoction prepared by the method of the invention in example 1 is added twice a day with 100ml each time, and the treatment course is 3 days, based on western medicine treatment according to fifth edition of diagnosis and treatment plan for pneumonia infected by novel coronavirus. And then timely adjusting according to the change of the disease condition until the disease turns to mild disease or severe disease, and then stopping.
Observation index and evaluation index
The observation includes the following aspects:
(1) changes of disease (body temperature, clinical manifestations, outcome, degree of disease and prognosis)
(2) Laboratory examinations (blood routine + CRP, procalcitonin, Lung CT, etc.)
Evaluation indexes are as follows:
(1) the main indexes are as follows: the rate and duration of mild symptoms are converted;
(2) secondary indexes are as follows: the incidence of complications; the rate of disease death;
data statistical analysis:
each index and data are standardized and processed using SPSS software. All statistical tests used a two-sided test, with differences of less than or equal to 0.05 being statistically significant.
As a result: the traditional Chinese medicine composition obviously improves respiratory symptoms, shortens the isolation days, reduces the incidence rate of critical illness, and has no obvious toxic or side effect.
Note: 1-wenzhou central hospital, 2-taizhou enrze hospital, the same as the same.
TABLE 1 Baseline cases of major clinical symptoms
TABLE 2 improvement of the major clinical symptoms
TABLE 3 Return to Condition
TABLE 4 Interval time to Normal type
TABLE 5 complications during hospitalization
Claims (5)
1. A traditional Chinese medicine composition for treating severe new coronary pneumonia is characterized by being prepared from the following raw materials in parts by mass: 10-20 parts of semen lepidii, 5-20 parts of snakegourd peel, 10-30 parts of wild buckwheat root, 10-30 parts of pulmonanthus japonicus, 10-30 parts of fried scutellaria baicalensis, 5-20 parts of perillaseed, 10-20 parts of allium macrostemon head, 10-20 parts of ginger processed pinellia tuber, 5-30 parts of cassia twig, 10-30 parts of raw white paeony root, 10-30 parts of ligusticum wallichii and 5-30 parts of semen brassicae.
2. The traditional Chinese medicine composition of claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: 15 parts of semen lepidii, 9 parts of snakegourd peel, 30 parts of wild buckwheat root, 30 parts of pulmonanthus, 30 parts of fried scutellaria baicalensis, 9 parts of perillaseed, 12 parts of allium macrostemon head, 12 parts of ginger processed pinellia tuber, 9 parts of cassia twig, 15 parts of raw white paeony root, 15 parts of ligusticum wallichii and 9 parts of brassica alba boiss.
3. The Chinese medicinal composition of claim 1, wherein the Chinese medicinal composition further comprises a pharmaceutically acceptable carrier in the form of decoction, granules or oral liquid.
4. A method for preparing the traditional Chinese medicine composition of claim 1, which is characterized by comprising the following steps: weighing semen Lepidii, pericarpium Trichosanthis, radix Fagopyri Esculenti, herba Euphorbiae Lunulatae, parched Scutellariae radix, fructus Perillae, Bulbus Allii Macrostemi, ginger processed pinellia Tuber, ramulus Cinnamomi, radix Paeoniae alba, rhizoma Ligustici Chuanxiong, and semen Sinapis Albae according to formula amount, adding 5 times of water, soaking for 1 hr, heating and decocting for 20 min, boiling, and filtering; and adding 3 times of water into the medicine residues, heating to boil, filtering after boiling, combining the filtrates, and concentrating until the density is 1.02-1.2 to obtain decoction.
5. The use of the Chinese medicinal composition of claim 1 in the preparation of a medicament for treating severe new crown pneumonia.
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杨珺超等: "浙江省《新型冠状病毒肺炎中医药防治推荐方案(试行第四版)》解读", 《浙江中医药大学学报》 * |
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