CN111110819A - Traditional Chinese medicine formula for treating or preventing novel coronavirus pneumonia and viral influenza - Google Patents

Traditional Chinese medicine formula for treating or preventing novel coronavirus pneumonia and viral influenza Download PDF

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CN111110819A
CN111110819A CN202010109651.XA CN202010109651A CN111110819A CN 111110819 A CN111110819 A CN 111110819A CN 202010109651 A CN202010109651 A CN 202010109651A CN 111110819 A CN111110819 A CN 111110819A
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parts
traditional chinese
chinese medicine
medicine formula
rhizome
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吴通武
梁力
张堂江
梁洪海
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine formula for treating or preventing novel coronavirus pneumonia and viral influenza, the traditional Chinese medicine formula comprises 15-45 parts of prepared aconite, 10-30 parts of dried ginger, 30-60 parts of honey-fried licorice root, 15-30 parts of American ginseng, 10-30 parts of ephedra, 15-30 parts of cassia twig, 5-10 parts of asarum, 10-70 parts of honeysuckle flower, 10-30 parts of fructus forsythiae, 10-30 parts of isatis root, 10-30 parts of reed rhizome, 15-30 parts of folium isatidis, 20-240 parts of gypsum, 10-30 parts of lalang grass rhizome, 10-15 parts of rhizoma paridis, 5-15 parts of wrinkled gianthyssop herb, 5-10 parts of eupatorium, 5-10 parts of safflower, 5-15 parts of cortex moutan, 5-15 parts of rheum officinale, 15-45 parts of ginger, 10-30 parts of Chinese date and 5-9 parts of musk. The traditional Chinese medicine formula disclosed by the invention has the effects of strengthening yang and strengthening physique, strengthening vital qi and eliminating evil, ventilating lung and relieving exterior syndrome, clearing heat and detoxifying, and eliminating turbid pathogen with aromatics, emphasizes on ventilating lung heat and improving human immunity, and can be used for preventing or treating coronavirus, influenza and pneumonia.

Description

Traditional Chinese medicine formula for treating or preventing novel coronavirus pneumonia and viral influenza
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine formula for treating or preventing novel coronavirus pneumonia and viral influenza.
Background
Influenza is an acute respiratory infectious disease caused by viruses. Due to the high variability of influenza viruses, the population is generally susceptible to outbreaks, and the disease progresses rapidly in a few cases, which can lead to death due to serious complications. The treatment and prevention of the antiviral drugs can be given in time, so that the influenza symptoms can be relieved, the disease course can be shortened, and the serious influenza complications can be prevented.
Human coronavirus (human coronavirus) infection is one of important pathogens causing human respiratory diseases, the detection rate of the coronavirus in common respiratory pathogens is about 3% -10%, and the human coronavirus is an important pathogen which infects infants, old people and adults with low immune function, so that clinical symptoms such as cough, fever, laryngitis, bronchitis, pneumonia and the like are caused. At present, seven kinds of human coronavirus are known, namely human coronavirus229E (Humancoronavirus229E, HCoV-229E) and HCoV-OC43 found in the sixties of the 19 th century, severe acute respiratory syndrome SARS-CoV (Severeaceus pityrisyndrome, SARS) coronavirus appearing in the Guangdong of China in 2003, novel human coronavirus NL63(HCoV-NL63) isolated and identified in the Netherlands in 2004, novel human coronavirus HKU1(HCoV-HKU1) isolated and identified in hong Kong in 2005, middle east respiratory syndrome (Middles syndrome, MERS) coronavirus MERS-CoV appearing in the middle east of China in 6 months in 2012, and novel coronavirus SARS-CoV-2.
Epidemiological research shows that four human coronaviruses, namely HCoV-229E, HCoV-NL63, HCoV-OC43 and HCoV-HKUI, are prevalent all over the world and are distributed globally, and clinical symptoms mainly include fever, cough, rhinitis, laryngitis, bronchitis, pneumonia and the like, so that the four human coronaviruses cause certain burden on the life health of human beings. Three coronaviruses, SARS-CoV, MERS-CoV and SARS-CoV-2, can cause acute respiratory symptoms after infecting human, and severe patients cause respiratory system and renal system failure and death.
At present, no effective antiviral medicament exists for coronavirus infection and influenza virus infection, and the development of related vaccines is difficult and serious. The traditional Chinese medicine has unique advantages in preventing and treating influenza, and modern pharmacological and clinical researches show that the traditional Chinese medicine has obvious inhibition effect on various viruses, has the characteristic of broad-spectrum antivirus, has the effects of relieving fever, regulating immunity, inhibiting inflammatory reaction and the like, and has the advantages that general antiviral western medicines do not have. Therefore, there is a need for a Chinese medicinal formulation that can prevent or treat coronavirus, influenza and pneumonia.
Disclosure of Invention
In view of the above, the present invention aims to provide a traditional Chinese medicine formula for treating or preventing novel coronavirus pneumonia and viral influenza, wherein the traditional Chinese medicine formula has the effects of strengthening yang and strengthening physique, strengthening healthy qi and eliminating pathogenic factors, ventilating and smoothing lung and relieving exterior syndrome, clearing heat and removing toxicity, eliminating turbid with aromatics, and emphasizing on ventilating and clearing lung heat and improving human immunity, and can be used for preventing or treating novel coronavirus pneumonia, influenza virus infection and pneumonia.
The invention solves the technical problems by the following technical means:
the invention provides a traditional Chinese medicine formula for treating or preventing novel coronavirus pneumonia and viral influenza, which comprises the following raw material medicines in parts by weight:
15-45 parts of prepared common monkshood daughter root, 10-30 parts of dried ginger, 30-60 parts of honey-fried licorice root, 15-30 parts of American ginseng, 10-30 parts of ephedra, 15-30 parts of cassia twig, 5-10 parts of asarum, 10-70 parts of honeysuckle flower, 10-30 parts of weeping forsythia, 10-30 parts of indigowoad root, 10-30 parts of reed rhizome, 15-30 parts of indigowoad leaf, 20-240 parts of gypsum, 10-30 parts of lalang grass rhizome, 10-15 parts of paris rhizome, 5-15 parts of wrinkled gianthyssop herb, 5-10 parts of fortune eupatorium herb, 5-10 parts of safflower, 5-15 parts of tree peony bark, 5-15 parts of rhubarb, 15-45 parts of heavy ginger, 10-30 parts of Chinese date and 5-.
Preferably, the traditional Chinese medicine formula comprises the following raw material medicines in parts by weight:
20-40 parts of prepared radix aconiti lateralis preparata, 15-25 parts of dried ginger, 35-50 parts of honey-fried licorice root, 18-26 parts of American ginseng, 13-28 parts of ephedra, 18-26 parts of cassia twig, 6-9 parts of asarum, 20-50 parts of honeysuckle flower, 13-28 parts of fructus forsythiae, 13-28 parts of isatis root, 13-28 parts of reed rhizome, 18-26 parts of folium isatidis, 50-200 parts of gypsum, 13-28 parts of lalang grass rhizome, 11-15 parts of rhizoma paridis, 6-13 parts of wrinkled gianthyssop herb, 6-9 parts of fortune eupatorium herb, 6-9 parts of safflower, 6-13 parts of cortex moutan, 6-13 parts of rheum officinale, 18-38 parts of regenerated ginger, 13-25 parts of Chinese date and 5-9 parts of musk.
Preferably, the traditional Chinese medicine formula comprises the following raw material medicines in parts by weight:
30 parts of prepared aconite, 20 parts of dried ginger, 42 parts of honey-fried licorice root, 19 parts of American ginseng, 16 parts of ephedra, 21 parts of cassia twig, 8 parts of asarum, 26 parts of honeysuckle flower, 21 parts of forsythia, 21 parts of isatis root, 18 parts of reed rhizome, 21 parts of dyers woad leaf, 158 parts of gypsum, 22 parts of cogongrass rhizome, 12 parts of paris rhizome, 8 parts of wrinkled gianthyssop, 7 parts of eupatorium, 7 parts of safflower, 8 parts of cortex moutan, 8 parts of rhubarb, 26 parts of heavy ginger, 15 parts of Chinese date and 6 parts of musk.
Preferably, the traditional Chinese medicine formula comprises the following raw material medicines in parts by weight:
40g of prepared aconite, 15g of dried ginger, 35g of honey-fried licorice root, 26g of American ginseng, 13g of ephedra, 26g of cassia twig, 9g of asarum, 50g of honeysuckle flower, 13g of forsythia, 13g of isatis root, 13g of reed rhizome, 26g of dyers woad leaf, 200g of gypsum, 28g of cogongrass rhizome, 15g of paris rhizome, 6g of wrinkled gianthyssop herb, 9g of eupatorium, 9g of safflower, 13g of cortex moutan, 13g of rhubarb, 38g of heavy ginger, 25g of Chinese date and 9g of musk.
Another aspect of the present invention provides a decocting method of the above traditional Chinese medicine formula for treating or preventing novel coronavirus pneumonia and viral influenza, wherein the decocting method comprises:
weighing the raw materials according to the weight parts of the raw materials, adding the weighed prepared aconite, dried ginger and honey-fried licorice root into water, opening a cover to decoct for 0.8-1.5 h, adding the weighed American ginseng, ephedra, cassia twig, honeysuckle, fructus forsythiae, isatis root, reed rhizome, folium isatidis, gypsum, lalang grass rhizome, rhizoma paridis, wrinkled gianthyssop herb, fortune eupatorium herb, safflower, cortex moutan, rhubarb, heavy ginger, Chinese date and musk, opening a cover to decoct for 0.8-1.5 h, then adding asarum, decocting for 6-15 min, and filtering to obtain the liquid medicine of the traditional Chinese medicine formula.
Preferably, the mass of the water is 10-20 times of the total mass of all the raw material medicines.
The invention further aims to provide application of the traditional Chinese medicine formula for treating or preventing the novel coronavirus pneumonia and the viral influenza, and the traditional Chinese medicine formula can be used for preventing or treating the novel coronavirus pneumonia, the influenza virus infection and the pneumonia.
Preferably, the traditional Chinese medicine formula is matched with arbidol for administration.
Radix Aconiti lateralis Preparata, Zingiberis rhizoma, and radix Glycyrrhizae Preparata for synergistic effect, and is used in combination with radix Panacis Quinquefolii for strengthening body resistance and eliminating pathogenic factors; herba Ephedrae, ramulus Cinnamomi, and herba asari have effects of relieving exterior syndrome, dispelling cold, and resolving fluid retention; flos Lonicerae, fructus forsythiae, radix Isatidis, and folium Isatidis can be used together for clearing away heat and toxic materials; gypsum Fibrosum is important in clearing lung heat, and rhizoma paridis is important in clearing heat and removing toxicity; the ageratum and the eupatorium herb are fragrant and turbid-removing without remaining toxicity; cortex moutan has effects in nourishing yin and clearing away heat; the ginger helps the numb and cassia bark to relieve exterior syndrome and dispel cold, and the Chinese date protects the spleen and the stomach; rhubarb, radix et rhizoma Rhei attacks accumulation and stagnation, clears damp-heat, purges fire, detoxifies and the like, all warm and toxic heat is discharged from the intestine of the Chinese angelica through the rhubarb, and has the synergistic effect of promoting blood circulation and cooling blood with the cogongrass rhizome and the safflower.
The traditional Chinese medicine formula disclosed by the invention has the effects of strengthening yang and strengthening physique, strengthening body resistance and eliminating evil, ventilating lung and relieving exterior syndrome, clearing heat and detoxifying, and eliminating turbid pathogen with aromatics, emphasizes on ventilating lung heat and improving human immunity, can effectively prevent novel coronavirus pneumonia and influenza virus infection, has a good treatment effect on diseases such as pneumonia caused by novel coronavirus and influenza virus infection, and is low in recurrence rate after cure. Most of the traditional Chinese medicine formula is prepared from plant traditional Chinese medicines, and the source is wide.
Detailed Description
The present invention will be described in detail with reference to specific examples below:
example 1
The traditional Chinese medicine formula for treating or preventing the novel coronavirus pneumonia and the novel coronavirus influenza comprises the following raw material medicines in mass:
30g of prepared aconite, 20g of dried ginger, 42g of honey-fried licorice root, 19g of American ginseng, 16g of ephedra, 21g of cassia twig, 8g of asarum, 26g of honeysuckle flower, 21g of weeping forsythia, 21g of isatis root, 18g of reed rhizome, 21g of indigowoad leaf, 158g of gypsum, 22g of cogongrass rhizome, 12g of paris rhizome, 8g of wrinkled gianthyssop herb, 7g of eupatorium, 7g of safflower, 8g of cortex moutan, 8g of rhubarb, 26g of heavy ginger, 15g of Chinese date and 6g of musk.
The traditional Chinese medicine formula of the embodiment is decocted as follows:
weighing the raw materials according to the mass, respectively, for standby use, adding the weighed prepared slice of aconite, dried ginger and honey-fried licorice into 5.4kg of water, boiling with strong fire, opening the cover with slow fire, decocting for 1h, adding the weighed American ginseng, ephedra, cassia twig, honeysuckle flower, weeping forsythia, isatis root, reed rhizome, dyers woad leaf, gypsum, lalang grass rhizome, paris polyphylla, wrinkled gianthyssop, fortune eupatorium herb, safflower, root bark of tree peony, rhubarb, heavy ginger, Chinese date and musk, opening the cover, decocting for 1h, then adding asarum, decocting for 8min, and filtering to obtain the liquid medicine of the.
Example 2
The traditional Chinese medicine formula for treating or preventing the novel coronavirus pneumonia and the novel coronavirus influenza comprises the following raw material medicines in mass:
28g of prepared aconite, 18g of dried ginger, 44g of honey-fried licorice root, 20g of American ginseng, 21g of ephedra, 19g of cassia twig, 7g of asarum, 33g of honeysuckle flower, 19g of weeping forsythia, 19g of isatis root, 19g of reed rhizome, 23g of indigowoad leaf, 180g of gypsum, 19g of cogongrass rhizome, 13g of rhizoma paridis, 9g of wrinkled gianthyssop herb, 8g of fortune eupatorium herb, 8g of safflower, 10g of tree peony bark, 10g of rhubarb, 22g of heavy ginger, 18g of Chinese date and 8g of.
Weighing the raw materials according to the mass, respectively, for later use, adding the weighed prepared slice of aconite, dried ginger and honey-fried licorice into 6.9kg of water, boiling with strong fire, opening the cover with slow fire, decocting for 1h, adding the weighed American ginseng, ephedra, cassia twig, honeysuckle flower, weeping forsythia, isatis root, reed rhizome, dyers woad leaf, gypsum, lalang grass rhizome, paris polyphylla, wrinkled gianthyssop, fortune eupatorium herb, safflower, root bark of tree peony, rhubarb, heavy ginger, Chinese date and musk, opening the cover, decocting for 1h, then adding asarum, decocting for 8min, and filtering to obtain the liquid medicine of the.
Example 3
The traditional Chinese medicine formula for treating or preventing the novel coronavirus pneumonia and the novel coronavirus influenza comprises the following raw material medicines in mass:
20g of prepared aconite, 25g of dried ginger, 45g of honey-fried licorice root, 24g of American ginseng, 28g of ephedra, 20g of cassia twig, 6g of asarum, 25g of honeysuckle flower, 25g of forsythia, 25g of isatis root, 25g of reed rhizome, 18g of dyers woad leaf, 50g of gypsum, 13g of cogongrass rhizome, 11g of paris rhizome, 13g of wrinkled gianthyssop, 6g of eupatorium, 6g of safflower, 6g of cortex moutan, 6g of rhubarb, 18g of heavy ginger, 13g of Chinese date and 5g of musk.
Weighing the raw materials according to the mass, respectively, for standby use, adding the weighed prepared slice of aconite, dried ginger and honey-fried licorice into 4.33kg of water, boiling with strong fire, opening the cover with slow fire, decocting for 0.8h, then adding the weighed American ginseng, ephedra, cassia twig, honeysuckle flower, fructus forsythiae, isatis root, reed rhizome, folium isatidis, gypsum, lalang grass rhizome, rhizoma paridis, wrinkled gianthyssop, fortune eupatorium herb, safflower, root bark of tree peony, rhubarb, heavy ginger, Chinese date and musk, opening the cover, decocting for 0.8h, then adding asarum, decocting for 6min, and filtering to obtain the liquid medicine of the traditional Chinese medicine formula.
Example 4
The traditional Chinese medicine formula for treating or preventing the novel coronavirus pneumonia and the novel coronavirus influenza comprises the following raw material medicines in mass:
40g of prepared aconite, 15g of dried ginger, 35g of honey-fried licorice root, 26g of American ginseng, 13g of ephedra, 26g of cassia twig, 9g of asarum, 50g of honeysuckle flower, 13g of forsythia, 13g of isatis root, 13g of reed rhizome, 26g of dyers woad leaf, 200g of gypsum, 28g of cogongrass rhizome, 15g of paris rhizome, 6g of wrinkled gianthyssop herb, 9g of eupatorium, 9g of safflower, 13g of cortex moutan, 13g of rhubarb, 38g of heavy ginger, 25g of Chinese date and 9g of musk.
Weighing the raw materials according to the mass, respectively, for standby use, adding the weighed prepared slice of aconite, dried ginger and honey-fried licorice into 7.72kg of water, boiling with big fire, opening the cover with small fire, decocting for 1h, adding the weighed American ginseng, ephedra, cassia twig, honeysuckle, forsythia, isatis root, reed rhizome, dyers woad leaf, gypsum, lalang grass rhizome, paris polyphylla, wrinkled gianthyssop, fortune eupatorium herb, safflower, root bark of tree peony, rhubarb, heavy ginger, Chinese date and musk, opening the cover, decocting for 1h, then adding asarum, decocting for 8min, and filtering to obtain the liquid medicine of the traditional Chinese medicine.
Example 5
The traditional Chinese medicine formula for treating or preventing the novel coronavirus pneumonia and the novel coronavirus influenza comprises the following raw material medicines in mass:
33g of prepared aconite, 23g of dried ginger, 50g of honey-fried licorice root, 18g of American ginseng, 21g of ephedra, 18g of cassia twig, 7g of asarum, 20g of honeysuckle flower, 28g of forsythia, 28g of isatis root, 28g of reed rhizome, 19g of dyers woad leaf, 120g of gypsum, 15g of cogongrass rhizome, 13g of paris rhizome, 9g of wrinkled gianthyssop herb, 8g of eupatorium, 8g of safflower, 11g of cortex moutan, 11g of rhubarb, 31g of heavy ginger, 19g of Chinese date and 6g of musk.
Weighing the raw materials according to the mass, respectively, for standby use, adding the weighed prepared slice of aconite, dried ginger and honey-fried licorice into 10.88kg of water, boiling with strong fire, opening the cover with slow fire, decocting for 1h, adding the weighed American ginseng, ephedra, cassia twig, honeysuckle flower, weeping forsythia, isatis root, reed rhizome, dyers woad leaf, gypsum, lalang grass rhizome, paris polyphylla, wrinkled gianthyssop, fortune eupatorium herb, safflower, root bark of tree peony, rhubarb, heavy ginger, Chinese date and musk, opening the cover, decocting for 1h, then adding asarum, decocting for 8min, and filtering to obtain the liquid medicine of the.
Example 6
The traditional Chinese medicine formula for treating or preventing the novel coronavirus pneumonia and the novel coronavirus influenza comprises the following raw material medicines in mass:
33g of prepared aconite, 19g of dried ginger, 41g of honey-fried licorice root, 18g of American ginseng, 18g of ephedra, 18g of cassia twig, 7g of asarum, 70g of honeysuckle flower, 22g of weeping forsythia, 22g of isatis root, 22g of reed rhizome, 19g of dyers woad leaf, 130g of gypsum, 30g of cogongrass rhizome, 14g of rhizoma paridis, 14g of wrinkled gianthyssop, 8g of eupatorium, 8g of safflower, 8g of cortex moutan, 8g of rhubarb, 26g of heavy ginger, 26g of Chinese date and 8g of musk.
Weighing the raw materials according to the mass, respectively, for standby use, adding 6.479kg of water into the weighed prepared aconite slice, the dried ginger and the honey-fried licorice root, boiling with big fire, opening the cover with small fire, decocting for 1h, adding the weighed American ginseng, the ephedra, the cassia twig, the honeysuckle, the weeping forsythia, the isatis root, the reed rhizome, the dyers woad leaf, the gypsum, the cogongrass rhizome, the paris rhizome, the wrinkled gianthyssop, the eupatorium, the safflower, the root bark of the peony tree, the rhubarb, the heavy ginger, the Chinese date and the musk, opening the cover, decocting for 1h, then adding.
Example 7
The traditional Chinese medicine formula for treating or preventing the novel coronavirus pneumonia and the novel coronavirus influenza comprises the following raw material medicines in mass:
15g of prepared aconite, 10g of dried ginger, 30g of honey-fried licorice root, 15g of American ginseng, 10g of ephedra, 15g of cassia twig, 5g of asarum, 15g of honeysuckle flower, 10g of forsythia, 10g of isatis root, 10g of reed rhizome, 30g of dyers woad leaf, 20g of gypsum, 28g of cogongrass rhizome, 10g of paris rhizome, 15g of wrinkled gianthyssop, 5g of eupatorium, 5g of safflower, 5g of cortex moutan, 5g of rhubarb, 20g of heavy ginger, 10g of Chinese date and 5g of musk.
Weighing the raw materials according to the mass, respectively, for later use, adding 4.545kg of water into the weighed prepared aconite, dried ginger and honey-fried licorice root, boiling with big fire, opening the cover with small fire, decocting for 1.2h, adding the weighed American ginseng, ephedra, cassia twig, honeysuckle flower, weeping forsythia, isatis root, reed rhizome, indigowoad leaf, gypsum, lalang grass rhizome, paris polyphylla, wrinkled gianthyssop, fortune eupatorium herb, safflower, root bark of tree peony, rhubarb, heavy ginger, Chinese date and musk, opening the cover, decocting for 1.2h, then adding asarum, decocting for 10min, and filtering to obtain the liquid medicine of the traditional Chinese.
Example 8
The traditional Chinese medicine formula for treating or preventing the novel coronavirus pneumonia and the novel coronavirus influenza comprises the following raw material medicines in mass:
45g of prepared aconite, 30g of dried ginger, 60g of honey-fried licorice root, 30g of American ginseng, 30g of ephedra, 30g of cassia twig, 10g of asarum, 10g of honeysuckle flower, 30g of weeping forsythia, 30g of isatis root, 30g of reed rhizome, 15g of indigowoad leaf, 240g of gypsum, 10g of cogongrass rhizome, 15g of rhizoma paridis, 5g of wrinkled gianthyssop herb, 10g of fortune eupatorium herb, 10g of safflower, 15g of tree peony bark, 15g of rhubarb, 45g of heavy ginger, 30g of Chinese date and 9g of.
Weighing the raw materials according to the mass, respectively, for later use, adding 9.802kg of water into the weighed prepared aconite, dried ginger and honey-fried licorice root, boiling with big fire, opening the cover with small fire, decocting for 1.5h, adding the weighed American ginseng, ephedra, cassia twig, honeysuckle flower, weeping forsythia, isatis root, reed rhizome, indigowoad leaf, gypsum, lalang grass rhizome, paris polyphylla, wrinkled gianthyssop, fortune eupatorium herb, safflower, root bark of tree peony, rhubarb, heavy ginger, Chinese date and musk, opening the cover, decocting for 1.5h, then adding asarum, decocting for 15min, and filtering to obtain the liquid medicine of the traditional Chinese.
The above-mentioned traditional Chinese medicine formulas of examples 1-8 are designed to strengthen yang and strengthen physique, strengthen healthy qi to eliminate pathogens, disperse lung qi and relieve exterior syndrome, clear heat and remove toxicity, dispel turbidity with aromatics, and strengthen lung heat, improve immunity of human body, and can be used for preventing or treating coronavirus, influenza, pneumonia and the like. The traditional Chinese medicine formula has a dose of one agent in two days when used for prevention, has a dose of one agent in one day when used for treatment, has a dose of about 500ml, and can also be taken together with arbidol. It is noted that, when the plaster is used for prevention, the plaster dosage is above 20 weight parts, and when the traditional Chinese medicine formula is used for treatment, the plaster dosage is within 240 weight parts.
Clinical trial example:
first, influenza virus test example
Clinical data: in the flu outbreak season, 100 out-patient treatment flu cases are randomly selected, the age is 25-60 years old, 50 men and 50 women.
Diagnostic criteria: according to the common clinical symptoms of fever, headache, hypodynamia, nasal obstruction, watery nasal discharge, dry cough, pharyngalgia and the like, the influenza virus infection can be diagnosed.
The treatment method comprises the following steps: dividing 100 influenza disease cases into two groups according to age and sex, wherein the first group selects the traditional Chinese medicine formula liquid medicine decocted in the embodiment 1 of the invention, 500ml is taken every day for a case, 500ml is taken every two days for the fourth day, and the traditional Chinese medicine formula liquid medicine is taken for ten times and then rechecked; the second group also adopts the traditional Chinese medicine formula liquid medicine decocted in the embodiment 1 of the invention, except that 500ml of the traditional Chinese medicine formula liquid medicine is taken for each case every day, 0.3g of arbidol is also taken for each case every day and is taken for three times, 500ml of the traditional Chinese medicine formula liquid medicine is taken every two days on the fourth day, and the arbidol is stopped and rechecked after ten times of taking of the traditional Chinese medicine formula liquid medicine.
The therapeutic effect judgment standard is as follows: after the nasal obstruction and nasal discharge are cured, common clinical symptoms such as nasal obstruction, sneeze, aversion to cold, fever, headache and the like disappear, and the body temperature returns to normal; the fever is relieved, and the clinical symptoms are relieved; no effect, no improvement or aggravation of clinical symptoms.
The clinical therapeutic effect of influenza virus is shown in table 1:
cases of disease Cure n (%) Improvement of quality n (%) Ineffective n (%)
First group 39(78.00) 9(18.00) 2(4.00)
Second group 42(84.00) 7(14.00) 1(2.00)
TABLE 1
The data in table 1 show that the traditional Chinese medicine formula can effectively inhibit influenza viruses, 50 influenza patients are treated by the single traditional Chinese medicine formula, 39 influenza patients are cured, and the cure rate is as high as 78%. The traditional Chinese medicine formula is matched with arbidol for administration, the inhibition effect on influenza virus is stronger, 50 cases of patients suffering from influenza are treated by combining the traditional Chinese medicine formula with the arbidol, 42 cases are cured, and the cure rate reaches 84.00%.
Second, example of infection test of novel coronavirus
Clinical data: in 2020, 1-2 months, 60 cases of novel coronavirus infection are randomly selected and diagnosed in clinic, wherein the age is 25-60 years, 40 cases are male, and 20 cases are female.
Diagnostic criteria: according to the clinical common symptoms of fever, hypodynamia, dry cough, multiple frostbite of the lung and the like, and the positive fluorescence detection of coronavirus nucleic acid in samples such as sputum, throat swab, lower respiratory secretion and the like, the novel coronavirus infection can be diagnosed.
The treatment method comprises the following steps: dividing 30 influenza disease cases into two groups according to age and sex, wherein the first group selects the traditional Chinese medicine formula liquid medicine decocted in the embodiment 4 of the invention, one liquid medicine is taken every 500ml, one liquid medicine is taken every day for a case, one liquid medicine is taken every two days after three liquid medicines are taken, the medicine dosage is reduced after the seventh liquid medicine is taken, one liquid medicine is taken every three days, and the rechecking is carried out after ten liquid medicines are taken; the second group also selects the decocted traditional Chinese medicine formula liquid medicine of the embodiment 4 of the invention, one traditional Chinese medicine formula liquid medicine is taken every 500ml, one traditional Chinese medicine formula liquid medicine is taken for a case every day, 0.3g of arbidol is also taken for a case every day, the administration is carried out for three times, the administration of arbidol is stopped after three times, the traditional Chinese medicine formula is changed into one administration every two days, the medicine dosage is reduced after the seventh administration, one administration is taken every three days, and the reexamination is carried out after ten doses are taken.
The therapeutic effect judgment standard is as follows: clinical common symptoms such as fever, dry cough, hypodynamia and the like disappear, the lung film is recovered to be normal, and the nucleic acid detection of coronavirus is negative; improvement, fever, debilitation elimination and dry cough alleviation, and positive coronavirus nucleic acid detection; no effect, no improvement or aggravation of clinical symptoms.
The clinical therapeutic effect of influenza virus is shown in table 2:
cases of disease Cure n (%) Improvement of quality n (%) Ineffective n (%)
First group 24(80.00) 6(20.00) 0(0.00)
Second group 26(86.67) 4(13.33) 0(0)
TABLE 2
The data in table 2 show that the traditional Chinese medicine formula can effectively treat the novel coronavirus pneumonia, 24 patients are cured after 30 confirmed cases take the traditional Chinese medicine formula, and the cure rate reaches 80%.
Typical cases are:
case 1: for a certain girald beetle, a male has slight cough in the age of 46 years, the cough is aggravated in the 21 st day, the low fever is 37.8 degrees in the 1 st and 20 th day in 2020, the cough is more severe in the 22 th day, and the patients are difficult to breathe, shortness and frequent sweating, the patients get worse in 23 days, the patients do not sleep at night, the patients feel shocked, and the patients go to the hospital for 24 days to draw blood, take a film and test a throat swab, so that the lungs are frequently worn with glass shadows, the nucleic acid of the coronavirus is detected to be positive, and the lung is determined to be infected with the novel coronavirus, influenza such as influenza A is eliminated, the traditional Chinese medicine formula is started to be taken under the guidance of a doctor for 26 days, after the third side medicine is taken, the symptoms are improved, the body temperature is normal, the appetite is increased, the sleep is normal, but with slight cough, after the seventh medicine is taken, the cough is basically stopped, the urine is relatively normal, after the tenth medicine is taken, the patient goes to a hospital for reexamination, the lung film is normal, and the detection of coronavirus nucleic acid is negative.
Case 2: in 28 days, under the guidance of a doctor, a woman starts to take the traditional Chinese medicine formula, the body temperature returns to normal on the second day, but the patient still coughs, and after taking the third medicine, the cough is relieved, the breathing is normal, the appetite is increased, the sleep is normal, after taking the fifth medicine, all uncomfortable symptoms basically disappear, after taking the seventh medicine, the patient goes to the hospital for reexamination, the lung film is normal, and the coronavirus nucleic acid is detected to be negative.
Case 3: in a certain week, male, 51 years old, has fever and cough symptoms in 1 month and 27 days of 2020, has 37.6 ℃ of body temperature detection, has aggravated cough in 28 days, has poor spirit accompanied with symptoms of hypodynamia, dizziness and dyspnea, has 38.5 ℃ of body temperature detection, has blood drawing, film making and throat swab detection in a hospital, has lung pathological changes, has positive coronavirus nucleic acid detection, determines that the lung is infected by novel coronavirus, starts to take the traditional Chinese medicine formula of the invention under the guidance of a doctor, one dose is taken every day in 29-31 days, one dose is about 500ml, takes 0.1g arbidol after half an hour after a meal, takes arbidol three times every day, takes patients in 2 months and 1 days normally without dizziness symptoms, but still has cough, bad appetite and bad sleep, stops taking arbidol in 2 months and 1 days, takes one traditional Chinese medicine formula every two days, and only has slight cough after taking a seventh traditional Chinese medicine formula liquid, the sleep is normal, the appetite is increased, a traditional Chinese medicine formula liquid medicine is taken every three days instead, after the tenth side is taken, discomfort symptoms are basically avoided, and the detection of coronavirus nucleic acid is negative.
Although the present invention has been described in detail with reference to the preferred embodiments, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted without departing from the spirit and scope of the invention as defined in the appended claims. The techniques, shapes, and configurations not described in detail in the present invention are all known techniques.

Claims (8)

1. The traditional Chinese medicine formula for treating or preventing novel coronavirus pneumonia and viral influenza is characterized by comprising the following raw material medicines in parts by weight:
15-45 parts of prepared common monkshood daughter root, 10-30 parts of dried ginger, 30-60 parts of honey-fried licorice root, 15-30 parts of American ginseng, 10-30 parts of ephedra, 15-30 parts of cassia twig, 5-10 parts of asarum, 10-70 parts of honeysuckle flower, 10-30 parts of weeping forsythia, 10-30 parts of indigowoad root, 10-30 parts of reed rhizome, 15-30 parts of indigowoad leaf, 20-240 parts of gypsum, 10-30 parts of lalang grass rhizome, 10-15 parts of paris rhizome, 5-15 parts of wrinkled gianthyssop herb, 5-10 parts of fortune eupatorium herb, 5-10 parts of safflower, 5-15 parts of tree peony bark, 5-15 parts of rhubarb, 15-45 parts of heavy ginger, 10-30 parts of Chinese date and 5-.
2. The traditional Chinese medicine formula for treating or preventing novel coronavirus pneumonia and viral influenza according to claim 1, which is characterized by comprising the following raw material medicines in parts by weight:
20-40 parts of prepared radix aconiti lateralis preparata, 15-25 parts of dried ginger, 35-50 parts of honey-fried licorice root, 18-26 parts of American ginseng, 13-28 parts of ephedra, 18-26 parts of cassia twig, 6-9 parts of asarum, 20-50 parts of honeysuckle flower, 13-28 parts of fructus forsythiae, 13-28 parts of isatis root, 13-28 parts of reed rhizome, 18-26 parts of folium isatidis, 50-200 parts of gypsum, 13-28 parts of lalang grass rhizome, 11-15 parts of rhizoma paridis, 6-13 parts of wrinkled gianthyssop herb, 6-9 parts of fortune eupatorium herb, 6-9 parts of safflower, 6-13 parts of cortex moutan, 6-13 parts of rheum officinale, 18-38 parts of regenerated ginger, 13-25 parts of Chinese date and 5-9 parts of musk.
3. The traditional Chinese medicine formula for treating or preventing novel coronavirus pneumonia and viral influenza according to claim 2, which is characterized by comprising the following raw material medicines in parts by weight:
30 parts of prepared aconite, 20 parts of dried ginger, 42 parts of honey-fried licorice root, 19 parts of American ginseng, 16 parts of ephedra, 21 parts of cassia twig, 8 parts of asarum, 26 parts of honeysuckle flower, 21 parts of forsythia, 21 parts of isatis root, 18 parts of reed rhizome, 21 parts of dyers woad leaf, 158 parts of gypsum, 22 parts of cogongrass rhizome, 12 parts of paris rhizome, 8 parts of wrinkled gianthyssop, 7 parts of eupatorium, 7 parts of safflower, 8 parts of cortex moutan, 8 parts of rhubarb, 26 parts of heavy ginger, 15 parts of Chinese date and 6 parts of musk.
4. The traditional Chinese medicine formula for treating or preventing novel coronavirus pneumonia and viral influenza according to claim 2, which is characterized by comprising the following raw material medicines in parts by weight:
40g of prepared aconite, 15g of dried ginger, 35g of honey-fried licorice root, 26g of American ginseng, 13g of ephedra, 26g of cassia twig, 9g of asarum, 50g of honeysuckle flower, 13g of forsythia, 13g of isatis root, 13g of reed rhizome, 26g of dyers woad leaf, 200g of gypsum, 28g of cogongrass rhizome, 15g of paris rhizome, 6g of wrinkled gianthyssop herb, 9g of eupatorium, 9g of safflower, 13g of cortex moutan, 13g of rhubarb, 38g of heavy ginger, 25g of Chinese date and 9g of musk.
5. The traditional Chinese medicine formula for treating or preventing novel coronavirus pneumonia and viral influenza according to any one of claims 1 to 4, wherein the decoction method of the traditional Chinese medicine formula is as follows:
weighing the raw materials according to the weight parts of the raw materials, adding the weighed prepared aconite, dried ginger and honey-fried licorice root into water, opening a cover to decoct for 0.8-1.5 h, adding the weighed American ginseng, ephedra, cassia twig, honeysuckle, fructus forsythiae, isatis root, reed rhizome, folium isatidis, gypsum, lalang grass rhizome, rhizoma paridis, wrinkled gianthyssop herb, fortune eupatorium herb, safflower, cortex moutan, rhubarb, heavy ginger, Chinese date and musk, opening a cover to decoct for 0.8-1.5 h, then adding asarum, decocting for 6-15 min, and filtering to obtain the liquid medicine of the traditional Chinese medicine formula.
6. The traditional Chinese medicine formula for treating or preventing novel coronavirus pneumonia and viral influenza according to claim 5, wherein the mass of the water is 10-20 times of the total mass of all the raw material medicines.
7. The use of a Chinese medicinal formulation for the treatment or prevention of novel coronavirus pneumonia and viral influenza as claimed in any one of claims 1 to 4, wherein the Chinese medicinal formulation can be used for the prevention or treatment of novel coronavirus pneumonia, influenza virus infection and pneumonia.
8. The use of the Chinese medicinal formulation for treating or preventing novel coronavirus pneumonia and viral influenza as claimed in claim 7, wherein the Chinese medicinal formulation is administered in combination with arbidol.
CN202010109651.XA 2020-02-22 2020-02-22 Traditional Chinese medicine formula for treating or preventing novel coronavirus pneumonia and viral influenza Pending CN111110819A (en)

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CN111298049A (en) * 2020-04-22 2020-06-19 南昌大学第一附属医院 Traditional Chinese medicine composition for treating novel coronavirus pneumonia and application thereof
CN111956616A (en) * 2020-09-08 2020-11-20 山西振东泰盛制药有限公司 Arbidol hydrochloride composite dry powder preparation, spray, gel and preparation method thereof
CN112138081A (en) * 2020-07-10 2020-12-29 贵州中医药大学第一附属医院 Medicine for resisting novel coronavirus and preparation method thereof
CN114470027A (en) * 2020-10-23 2022-05-13 广州白云山和记黄埔中药有限公司 New application of compound isatis root

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111298049A (en) * 2020-04-22 2020-06-19 南昌大学第一附属医院 Traditional Chinese medicine composition for treating novel coronavirus pneumonia and application thereof
CN112138081A (en) * 2020-07-10 2020-12-29 贵州中医药大学第一附属医院 Medicine for resisting novel coronavirus and preparation method thereof
CN111956616A (en) * 2020-09-08 2020-11-20 山西振东泰盛制药有限公司 Arbidol hydrochloride composite dry powder preparation, spray, gel and preparation method thereof
CN114470027A (en) * 2020-10-23 2022-05-13 广州白云山和记黄埔中药有限公司 New application of compound isatis root

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Application publication date: 20200508