CN102670959B - Anti-influenza Chinese herba preparation and preparation method thereof - Google Patents
Anti-influenza Chinese herba preparation and preparation method thereof Download PDFInfo
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Abstract
The invention relates to anti-influenza Chinese herba preparation and preparation method thereof, wherein the anti-influenza Chinese herba preparation is made from eight tastes of Chinese herbal medicine which are cyrtomium rhizome, chrysanthemum, saposhnicovia divaricata, phillyrin, herba houttuyniae, rhizoma atractylodis, fortune eupatorium herb and radix ophiopogonis, and is suitable for symptom such as fever, headache, bodily pain and cough and the like caused by influenza, and has the effects of refrigerating, postoperative analgesia, anti-inflammation, relieving cough and relieving asthma and the like. The anti-influenza Chinese herba preparation does not have irritation, discomfort and side effect, is high in bioavailability, rapidly dilutes medicine, rapidly shows effect, is precise in treat therapy effect of nfluenza, rich in raw material sources and low in cost, does not have pollution during production process, and is suitable for industrial mass production.
Description
Affiliated technical field
The present invention relates to the field of Chinese medicines, relate in particular to Chinese medicine preparation of a kind of influenza and preparation method thereof.
Background technology
Influenza is grippal abbreviation, often can be popular on a large scale, and bring many inconvenience to people's work and life.Current influenza has become the upper a great problem of society, and the medicine that is also of no curative effect definite suppresses it.Influenza outbreak be in recent years scope wide, propagate fast, the cycle is long, the easy feature of recurrence after drug withdrawal, not only to people, bring the discomfort on health, and cause very large economic loss.
Influenza is the Acute respiratory infectious disease being caused by influenza virus, and pathogen is first, second, the third three type influenza viruss, especially common with A type.Virus is the biology that nature is small, and through the mankind research course of more than 100 years, the mankind have progressively disclosed viral characteristic and viruses and man, natural mutual relation.But, the mankind to viral understanding still seldom, to 5,000 kinds of natural boundary treatys viral 95%, still know nothing.This is mainly to allow mankind's unpredictable due to viral variability.
Virus is by variation, can obtain the characteristic that the past does not have, become can cross over species very soon, toxicity is stronger, the virus that infectiousness is higher, the influenza virus that we often say has eight genetic fragments, each genetic fragment also has five subgenomic fragments, these genetic fragments and the numerous rare and another kind of congenerous disease drug case of subgenomic fragment genetic fragment reprovision variations, can be described as the virus that toxicity is stronger, infectiousness is higher, make people's unpredictable, inhibition, eliminate it and be difficult to, current popular sexuality is emitted thus becomes the upper a great problem of society.Existing chemical drugs treatment influenza is not fully up to expectations, generally can only play some effects of improving symptom, and have side effect in various degree, and the immune system of human body self is had to injury.
The present invention is exactly the good medicine of resisiting influenza virus, and infected by influenza has unique curative effect, and the heating that popularity flu causes, headache, general pain, pharyngalgia, cough, asthma etc. have the therapeutic effect getting instant result.
Summary of the invention
The object of the present invention is to provide a kind of easy to use, onset is rapid, curative effect is high, the Chinese medicine preparation of the influenza that has no side effect and preparation method thereof.
For achieving the above object, being implemented as follows of technical scheme of the present invention:
A Chinese medicine preparation for influenza, raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
20～40 parts of 30～55 parts of Fructus Forsythiaes of 30～50 parts of Radix Saposhnikoviaes of 30～55 parts of Flos Chrysanthemis of Rhizoma Osmundae
8～15 parts of 15～28 portions of Herba Eupatoriis of 35～50 parts of Rhizoma Atractylodis of Herba Houttuyniae 20～35 parts of Radix Ophiopogonis
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
25～35 parts of 38～50 parts of Fructus Forsythiaes of 35～42 parts of Radix Saposhnikoviaes of 35～50 parts of Flos Chrysanthemis of Rhizoma Osmundae
10～13 parts of 18～25 portions of Herba Eupatoriis of 38～46 parts of Rhizoma Atractylodis of Herba Houttuyniae 22～30 parts of Radix Ophiopogonis
Raw material composition and the parts by weight of making described Chinese medicine preparation effective ingredient are:
30 parts of 42 parts of Fructus Forsythiaes of 38 parts of Radix Saposhnikoviaes of 40 parts of Flos Chrysanthemis of Rhizoma Osmundae
12 parts of 22 portions of Herba Eupatoriis of 42 parts of Rhizoma Atractylodis of Herba Houttuyniae 25 parts of Radix Ophiopogonis
The preparation method of Chinese medicine preparation, comprise following processing step:
(1) Rhizoma Osmundae is broken into Powdered, adds water, soaked overnight; At a simmer to surplus 100 milliliters of liquid, taking-up decocting liquid, cooling; Adjust between pH value 6～8, common filter paper filtering, filtrate is concentrated, and to obtain relative density be 1.15～1.23 clear paste.
(2) all the other raw materials are decocted with water 3 times, each 1.5 hours, to filter, it is 1.15～1.23 clear paste that filtrate is concentrated into relative density.
(3) clear paste obtaining in blend step (1) and step (2), continues to be concentrated into relative density and is more than or equal to 1.26 thick paste, adds adjuvant and get final product.
The present invention ties up under motherland's medicine and pharmacology theoretical direction, through clinical observation for many years, sums up.By a large amount of cases, confirm that the symptoms such as the heating that infected by influenza causes, headache, general pain, pharyngalgia, cough, asthma have unique definite curative effect.The Chinese medicine compound that Chinese medicine preparation formula of the present invention is comprised of eight taste Chinese medicines, wherein Rhizoma Osmundae, Flos Chrysanthemi are monarch drug, and Radix Saposhnikoviae, Fructus Forsythiae, Herba Houttuyniae are ministerial drug, and Rhizoma Atractylodis, Herba Eupatorii are adjuvant drug, and Radix Ophiopogonis is for making medicine.Rhizoma Osmundae heat-clearing and toxic substances removing, cooling blood for hemostasis, expelling wind and activating blood circulation in side, Flos Chrysanthemi is the key medicine of relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, heat-clearing and toxic substances removing, wind-dispelling heat-dissipating, two medicines share, and are all monarch drug, gather altogether the function that relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, lung qi dispersing bring down a fever; Radix Saposhnikoviae has relieving the exterior syndrome with drugs of pungent in flavor and warm in nature, expelling pathogenic factors from muscles by diaphoresis, the sensible effect of opening nose, the loose lung qi of a surname, Fructus Forsythiae is the product of clearing up internal heat by using drugs of bitter in taste and cold in nature, the pharmacological action that has antibiotic, heart tonifying, diuresis, town to tell, Herba Houttuyniae heat-clearing and toxic substances removing, removing pus and relieving carbuncle, inducing diuresis for treating stranguria syndrome, three medicines share and are all ministerial drug, with monarch drug compatibility to help its a surname to send out the function of lung qi, urinate removing toxic substances, relieving the exterior syndrome by diaphoresis; Rhizoma Atractylodis are drying damp and strengthening spleen, expelling wind and cold, let out drink expectorant, and Herba Eupatorii has Xin Xiang and walks to alter, loose skin, hair key, lung heat clearing expectorant thoroughly, and two medicines share, and are all adjuvant drug, and two medicines altogether principal drug assistance are evacuated cold-evil, clearing away lung-heat to relieve cough; Radix Ophiopogonis is for making medicine, can Yin-nourishing and body fluid promoting, nourishing the lung to arrest cough, relieving restlessness clears away heart-fire.All medicine 5 use, play the pungent table that cools completely, the effect of removing heat from QI system with drugs of pungent flavor and cold nature altogether.
Medicine of the present invention is applicable to the diseases such as upper respiratory tract infection that influenza causes, heating, headache, general pain, pharyngalgia, cough, asthma.Through pharmacodynamics test, show, medicine of the present invention has good antitoxin, analgesic, antiinflammatory, eliminates the phlegm, antitussive effect.Clinically be used for the treatment of influenza for many years, determined curative effect not only, and have no toxic and side effects.
The present invention compared with prior art, has following beneficial effect:
Chinese medicine preparation of the present invention has the effect that heat-clearing and toxic substances removing, anti-inflammatory analgesic, diaphoresis expelling pathogenic factors from muscles, cough-relieving are washed and coughed, relieving asthma and reduce phlegm, take after this Chinese medicine preparation onset rapidly, determined curative effect, have no side effect and untoward reaction, cheap, taking convenience, all-ages, do not develop immunity to drugs.
Resisiting influenza virus test in body:
Virus: with influenza virus A 1 hypotype Mus lung adapted strain FM1 (H1N1).Animal: 6 week age mice, sex is identical.Positive control medicine: Kugan granule.Virus virulence mensuration, drug toxicity mensuration, Antiviral Effect test have been carried out.Result proves that this Chinese medicine preparation is effective to influenza virus in body.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and parts by weight are:
20～40 parts of 30～55 parts of Fructus Forsythiaes of 30～50 parts of Radix Saposhnikoviaes of 30～55 parts of Flos Chrysanthemis of Rhizoma Osmundae
8～15 parts of 15～28 portions of Herba Eupatoriis of 35～50 parts of Rhizoma Atractylodis of Herba Houttuyniae 20～35 parts of Radix Ophiopogonis
The processing step of Chinese medicine preparation preparation method of the present invention is:
(1) Rhizoma Osmundae is broken into Powdered, adds water, soaked overnight; At a simmer to surplus 100 milliliters of liquid, taking-up decocting liquid, cooling; Adjust between pH value 6～8, common filter paper filtering, filtrate is concentrated, and to obtain relative density be 1.15～1.23 clear paste.
(2) all the other raw materials are decocted with water 3 times, each 1.5 hours, to filter, it is 1.15～1.23 clear paste that filtrate is concentrated into relative density.
(3) clear paste obtaining in blend step (1) and step (2), continues to be concentrated into relative density and is more than or equal to 1.26 thick paste, adds adjuvant and get final product.
Embodiment 2
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and parts by weight are:
25～35 parts of 38～50 parts of Fructus Forsythiaes of 35～42 parts of Radix Saposhnikoviaes of 35～50 parts of Flos Chrysanthemis of Rhizoma Osmundae
10～13 parts of 18～25 portions of Herba Eupatoriis of 38～46 parts of Rhizoma Atractylodis of Herba Houttuyniae 22～30 parts of Radix Ophiopogonis
The Chinese medicine preparation preparation method processing step of the present embodiment is identical with embodiment 1.
Embodiment 3
The raw material of Chinese medicine preparation effective ingredient of the present invention forms and parts by weight are:
30 parts of 42 parts of Fructus Forsythiaes of 38 parts of Radix Saposhnikoviaes of 40 parts of Flos Chrysanthemis of Rhizoma Osmundae
12 parts of 22 portions of Herba Eupatoriis of 42 parts of Rhizoma Atractylodis of Herba Houttuyniae 25 parts of Radix Ophiopogonis
The Chinese medicine preparation preparation method processing step of the present embodiment is identical with embodiment 1.
Chinese medicine preparation acute toxicity test in mice of the present invention:
Chinese medicine preparation of the present invention is carried out to acute toxicity test in mice, can not find the dosage that gavage causes dead mouse.Give respectively oral dose of 20 male and female half and half mices be 74.8 grams of crude drugs/kilogram Chinese medicine preparation of the present invention, observe after administration animal dead and abnormal response situation in 10 days.Result of the test shows: under this dosage, mice is without dead and any toxic reaction.Animal hair color, diet, defecation, activity are all normal.Results suggest: the chmice acute per os maximum tolerated dose of Chinese medicine preparation of the present invention be 74.8 grams of crude drugs/kilogram, be equivalent to the clinical plan of people with 99.7 times of dosage, medicine taking prompting safety.
Chinese medicine preparation mice of the present invention chronic toxicity test:
Chinese medicine preparation of the present invention is carried out to mice chronic toxicity test, give respectively 20 male and female, half and half mice take every day 12.6 grams of crude drugs/kilogram, once a day, continuous 90 days, Mouse Weight coefficient, organ coefficient, routine blood test, blood biochemistry detection index were all without extremely.Main organs histopathologic examination is also without pathological change.
Claims (3)
1. a Chinese medicine preparation for influenza, is characterized in that: the raw material of making described Chinese medicine preparation effective ingredient forms and parts by weight are:
20～40 parts of 30～55 parts of Fructus Forsythiaes of 30～50 parts of Radix Saposhnikoviaes of 30～55 parts of Flos Chrysanthemis of Rhizoma Osmundae
8～15 parts of 15～28 portions of Herba Eupatoriis of 35～50 parts of Rhizoma Atractylodis of Herba Houttuyniae 20～35 parts of Radix Ophiopogonis.
2. the Chinese medicine preparation of a kind of influenza according to claim 1, is characterized in that: the raw material of making described Chinese medicine preparation effective ingredient forms and parts by weight are:
25～35 parts of 38～50 parts of Fructus Forsythiaes of 35～42 parts of Radix Saposhnikoviaes of 35～50 parts of Flos Chrysanthemis of Rhizoma Osmundae
10～13 parts of 18～25 portions of Herba Eupatoriis of 38～46 parts of Rhizoma Atractylodis of Herba Houttuyniae 22～30 parts of Radix Ophiopogonis.
3. the Chinese medicine preparation of a kind of influenza according to claim 2, is characterized in that: the raw material of making described Chinese medicine preparation effective ingredient forms and parts by weight are:
30 parts of 42 parts of Fructus Forsythiaes of 38 parts of Radix Saposhnikoviaes of 40 parts of Flos Chrysanthemis of Rhizoma Osmundae
12 parts of 22 portions of Herba Eupatoriis of 42 parts of Rhizoma Atractylodis of Herba Houttuyniae 25 parts of Radix Ophiopogonis.
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| CN201210136855.8A CN102670959B (en) | 2012-04-30 | 2012-04-30 | Anti-influenza Chinese herba preparation and preparation method thereof |
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| CN201210136855.8A CN102670959B (en) | 2012-04-30 | 2012-04-30 | Anti-influenza Chinese herba preparation and preparation method thereof |
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| CN102670959A CN102670959A (en) | 2012-09-19 |
| CN102670959B true CN102670959B (en) | 2014-01-22 |
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| CN105796872A (en) * | 2016-05-13 | 2016-07-27 | 孔伟 | Anti-influenza traditional Chinese medicine preparation |
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Non-Patent Citations (2)
| Title |
|---|
| 景姗等.流行性感冒中医治疗概况.《中国中医药信息杂志》.2008,第15卷77-79. |
| 流行性感冒中医治疗概况;景姗等;《中国中医药信息杂志》;20080531;第15卷;77-79 * |
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