CN106177156A - A kind of Chinese medicine composition preventing and treating infectious bovine rhinotrachetis and application thereof - Google Patents

A kind of Chinese medicine composition preventing and treating infectious bovine rhinotrachetis and application thereof Download PDF

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Publication number
CN106177156A
CN106177156A CN201610724350.1A CN201610724350A CN106177156A CN 106177156 A CN106177156 A CN 106177156A CN 201610724350 A CN201610724350 A CN 201610724350A CN 106177156 A CN106177156 A CN 106177156A
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parts
radix
chinese medicine
medicine composition
infectious bovine
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Inventor
贺泂杰
郭慧琳
贺奋义
王春梅
杨峰
王晓力
杨明
朱新强
车小蛟
张登基
胡宇
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Lanzhou Institute of Animal Husbandry and Veterinary Medicine CAAS
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Lanzhou Institute of Animal Husbandry and Veterinary Medicine CAAS
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Priority to CN201610724350.1A priority Critical patent/CN106177156A/en
Publication of CN106177156A publication Critical patent/CN106177156A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/17Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/19Acanthaceae (Acanthus family)
    • A61K36/195Strobilanthes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233Bupleurum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315Isatis, e.g. Dyer's woad
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/346Platycodon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488Pueraria (kudzu)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534Mentha (mint)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/538Schizonepeta
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634Forsythia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718Coptis (goldthread)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/808Scrophularia (figwort)

Abstract

A kind of Chinese medicine composition preventing and treating infectious bovine rhinotrachetis that the present invention provides, including the crude drug of following weight portion: Lasiosphaera Seu Calvatia 15~25 parts, Fructus Arctii 25~35 parts, Radix Scrophulariae 25~35 parts, Radix Bupleuri 25~35 parts, Radix Isatidis 15~25 parts, Rhizoma Cimicifugae 15~24 parts, Radix Scutellariae 25~34 parts, Rhizoma Coptidis 15~30 parts, Radix Platycodonis 15~25 parts, Fructus Forsythiae 30~40 parts, Herba Menthae 18~25 parts, Herba Schizonepetae 25~32 parts, Herba Ephedrae 15~20 parts, Radix Puerariae 18~25 parts, Radix Glycyrrhizae 25~35 parts.By compounding for above-mentioned Chinese medicine having heat-clearing and toxic substances removing, sore-throat relieving dissipates swollen, the effect of invigorating the spleen and replenishing QI, the focus thus the active substance of Chinese medicine goes directly.Chinese medicine composition of the present invention has good effect, instant effect, the feature that cure rate is high in the application prevent and treat infectious bovine rhinotrachetis.

Description

A kind of Chinese medicine composition preventing and treating infectious bovine rhinotrachetis and application thereof
Technical field
The invention belongs to herbal medicine technical field, be specifically related to a kind of Chinese medicine composition preventing and treating infectious bovine rhinotrachetis And application.
Background technology
Infectious bovine rhinotrachetis (IBR), also known as " gangrenosum acne rhinitis ", " red cacorhinia ", is I type bovine herpes virus (BHV-1) A kind of bovine respiratory contagious disease caused.Clinical manifestations is various, based on respiratory tract.Numerous respiratory tracts cattle In disease, infectious bovine rhinotrachetis is the most refractory disease of respiratory tract disease.Cattle once infected cattle infectious bovine rhinotracheitis, Easily there are conjunctivitis, miscarriage, mastitis, sometimes induction calf encephalitis etc. in infected cattle body, this not only affects production performance and the most easily goes out Existing death, infected cattle or viral communication source simultaneously, virus with having in mind, nasal discharge and seminal fluid and vaginal secretion discharge, By approach such as the air spittle, copulation, virus is transmitted to susceptible cattle by respiratory tract or genitals, in turn result in same canopy or This disease of the cattle infected of same plant.
Traditional prevention and Therapeutic Method are to take the comprehensive measures such as quarantine, isolation, block, sterilization, to the most infected Cattle can inoculate attenuated vaccine or inactivated vaccine, the calf serum that immunity cow is produced can detect maternal antibody, but effectively Phase only continues 4 months, and the interference of maternal antibody simultaneously can affect the generation of active immunity.The most ill cattle can also drunk Water or feedstuff add antibiotic carry out preventing and treating.But owing on the trachea of cattle, blood vessel is little, if passing through antibiosis Extract for treating, medicine is difficult to arrive ill trachea position by blood, thus curative effect is little, and the antibiotic simultaneously remained also can be right Environment has undesirable effect.
Summary of the invention
In view of this, it is an object of the invention to provide a kind of Chinese medicine composition preventing and treating infectious bovine rhinotrachetis, Prevent and treat and the application of infectious bovine rhinotrachetis has good effect, instant effect, the feature that cure rate is high.
In order to realize foregoing invention purpose, the present invention provides techniques below scheme:
The invention provides a kind of Chinese medicine composition preventing and treating infectious bovine rhinotrachetis, including the raw material of following weight portion Medicine: Lasiosphaera Seu Calvatia 15~25 parts, Fructus Arctii 25~35 parts, Radix Scrophulariae 25~35 parts, Radix Bupleuri 25~35 parts, Radix Isatidis 15~25 parts, Rhizoma Cimicifugae 15~24 parts, Radix Scutellariae 25~34 parts, Rhizoma Coptidis 15~30 parts, Radix Platycodonis 15~25 parts, Fructus Forsythiae 30~40 parts, Herba Menthae 18~25 parts, chaste tree Mustard fringe 25~32 parts, Herba Ephedrae 15~20 parts, Radix Puerariae 18~25 parts, Radix Glycyrrhizae 25~35 parts.
Preferably, including the crude drug of following weight portion: Lasiosphaera Seu Calvatia 18~22 parts, Fructus Arctii 26~30 parts, Radix Scrophulariae 27~30 Part, Radix Bupleuri 26~30 parts, Radix Isatidis 18~23 parts, Rhizoma Cimicifugae 16~20 parts, Radix Scutellariae 28~32 parts, Rhizoma Coptidis 19~25 parts, Radix Platycodonis 16 ~20 parts, Fructus Forsythiae 32~35 parts, Herba Menthae 19~23 parts, Herba Schizonepetae 27~30 parts, Herba Ephedrae 16~19 parts, Radix Puerariae 20~24 parts, sweet Grass 28~32 parts.
Preferably, including the crude drug of following weight portion: Lasiosphaera Seu Calvatia 20 parts, Fructus Arctii 28 parts, Radix Scrophulariae 28 parts, Radix Bupleuri 27 parts, Radix Isatidis 20 parts, Rhizoma Cimicifugae 18 parts, Radix Scutellariae 30 parts, Rhizoma Coptidis 22 parts, Radix Platycodonis 17 parts, Fructus Forsythiae 33 parts, Herba Menthae 20 parts, Herba Schizonepetae 28 parts, 18 parts of Herba Ephedrae, Radix Puerariae 22 parts, 30 parts of Radix Glycyrrhizae.
The invention provides the application in preparation prevents and treats the medicine of infectious bovine rhinotrachetis of the described Chinese medicine composition.
Preferably, described infectious bovine rhinotrachetis is caused by intestinal I type bovine herpes virus.
Present invention also offers a kind of medicine preventing and treating infectious bovine rhinotrachetis, including Chinese medicine composition and medically connect The adjuvant being subject to, described Chinese medicine composition is the Chinese medicine composition described in technique scheme.
Preferably, the dosage form of described medicine is oral agents.
A kind of Chinese medicine composition preventing and treating infectious bovine rhinotrachetis that the present invention provides, including the raw material of following weight portion Medicine: Lasiosphaera Seu Calvatia 15~25 parts, Fructus Arctii 25~35 parts, Radix Scrophulariae 25~35 parts, Radix Bupleuri 25~35 parts, Radix Isatidis 15~25 parts, Rhizoma Cimicifugae 15~24 parts, Radix Scutellariae 25~34 parts, Rhizoma Coptidis 15~30 parts, Radix Platycodonis 15~25 parts, Fructus Forsythiae 30~40 parts, Herba Menthae 18~25 parts, chaste tree Mustard fringe 25~32 parts, Herba Ephedrae 15~20 parts, Radix Puerariae 18~25 parts, Radix Glycyrrhizae 25~35 parts.By compounding for above-mentioned Chinese medicine, there is heat clearing away solution Poison, sore-throat relieving dissipate swollen, the effect of invigorating the spleen and replenishing QI, the focus thus the active substance of Chinese medicine goes directly.Chinese medicine composition of the present invention There is in the application prevent and treat infectious bovine rhinotrachetis good effect, instant effect, the feature that cure rate is high.
The invention provides the application in preparation prevents and treats the medicine of infectious bovine rhinotrachetis of the described Chinese medicine composition. Use the present invention provide Chinese medicine composition take continuously five days, cattle disease symptom all disappears, cure rate more than 98.4%, Chinese medicine composition described in explanation has good effect, instant effect in the application prevent and treat infectious bovine rhinotrachetis, and cure rate is high Feature.
Detailed description of the invention
The invention provides a kind of Chinese medicine composition preventing and treating infectious bovine rhinotrachetis, including the raw material of following weight portion Medicine: Lasiosphaera Seu Calvatia 15~25 parts, Fructus Arctii 25~35 parts, Radix Scrophulariae 25~35 parts, Radix Bupleuri 25~35 parts, Radix Isatidis 15~25 parts, Rhizoma Cimicifugae 15~24 parts, Radix Scutellariae 25~34 parts, Rhizoma Coptidis 15~30 parts, Radix Platycodonis 15~25 parts, Fructus Forsythiae 30~40 parts, Herba Menthae 18~25 parts, chaste tree Mustard fringe 25~32 parts, Herba Ephedrae 15~20 parts, Radix Puerariae 18~25 parts, Radix Glycyrrhizae 25~35 parts.
The invention provides a kind of Chinese medicine composition preventing and treating infectious bovine rhinotrachetis, have compounding for plurality of Chinese clearly Thermal detoxification, sore-throat relieving dissipate swollen, the effect of invigorating the spleen and replenishing QI, the focus thus the active substance of Chinese medicine goes directly.Chinese drug-treated group of the present invention Compound has good effect, instant effect, the feature that cure rate is high in the application prevent and treat infectious bovine rhinotrachetis.
The raw material of the Chinese medicine composition preventing and treating infectious bovine rhinotrachetis that the present invention provides includes 15~25 parts of Lasiosphaera Seu Calvatia, excellent Elect 18~22 parts as, more preferably 20 parts.In the present invention, described Lasiosphaera Seu Calvatia has a local hemostatic, double controls throat pain, aphonia etc. Effect.The source of described Lasiosphaera Seu Calvatia is not particularly limited by the present invention, uses the commercially available of Lasiosphaera Seu Calvatia well-known to those skilled in the art Commodity.
The raw material of the Chinese medicine composition preventing and treating infectious bovine rhinotrachetis that the present invention provides includes 25~35 parts of Fructus Arctiis, It is preferably 26~30 parts, more preferably 28 parts.In the present invention, described Fructus Arctii dispelling wind and heat pathogens, heat-clearing and toxic substances removing rash, lung qi dispersing profit Pharynx dissipates swollen.The source of described Fructus Arctii is not particularly limited by the present invention, uses Fructus Arctii well-known to those skilled in the art Commercial goods.
Raw material in the Chinese medicine composition preventing and treating infectious bovine rhinotrachetis that the present invention provides includes 25~35 portions of Radix Scrophulariaes, It is preferably 27~30 parts, more preferably 28 parts.In the present invention, described Radix Scrophulariae clearing away heat and cooling blood, nourishing YIN to lower pathogenic fire, detoxicating and resolving stagnation of pathogens.This Invent the source to described Radix Scrophulariae to be not particularly limited, use the commercial goods of Radix Scrophulariae well-known to those skilled in the art i.e. Can.
Raw material in the Chinese medicine composition preventing and treating infectious bovine rhinotrachetis that the present invention provides includes 25~35 parts of Radix Bupleuri, It is preferably 26~30 parts, more preferably 27 parts.In the present invention, described Radix Bupleuri reconciling superficies and interior, dispersing the stagnated live-QI to relieve the stagnation of QI, ascending up spleen-Qi and Yang, moves back Hot preventing the attack (or recurrence) of malaria.The source of described Radix Bupleuri is not particularly limited by the present invention, uses the city of Radix Bupleuri well-known to those skilled in the art Sell commodity.
Raw material in a kind of Chinese medicine composition preventing and treating infectious bovine rhinotrachetis that the present invention provides includes 15~25 parts Radix Isatidis, preferably 18~23 parts, more preferably 20 parts.In the present invention, described Radix Isatidis heat-clearing and toxic substances removing, removing heat from blood, sore-throat relieving.This Invent the source to described Radix Isatidis to be not particularly limited, use the commercial goods of Radix Isatidis well-known to those skilled in the art ?.
Raw material in a kind of Chinese medicine composition preventing and treating infectious bovine rhinotrachetis that the present invention provides includes 15~24 parts Rhizoma Cimicifugae, preferably 16~20 parts, more preferably 18 parts.In the present invention, described Rhizoma Cimicifugae delivers rash, heat-clearing and toxic substances removing, and yang invigorating is lifted Fall into.The source of described Rhizoma Cimicifugae is not particularly limited by the present invention, uses the commercially available business of Rhizoma Cimicifugae well-known to those skilled in the art Product.
Raw material in a kind of Chinese medicine composition preventing and treating infectious bovine rhinotrachetis that the present invention provides includes 25~34 parts Radix Scutellariae, preferably 28~32 parts, more preferably 30 parts.In the present invention, described Radix Scutellariae removing the relative excess fire, dehumidifying heat, hemostasis, antiabortive. Control high fever excessive thirst, cough due to lung-heat, damp-heat dysentery, jaundice, pyretic stranguria, tell, be defeated in battle, collapse, leak, conjunctival congestion and swelling pain, frequent fetal movement, carbuncle furuncle Skin ulcer.The source of described Radix Scutellariae is not particularly limited by the present invention, uses the commercially available business of Radix Scutellariae well-known to those skilled in the art Product.
Raw material in a kind of Chinese medicine composition preventing and treating infectious bovine rhinotrachetis that the present invention provides includes 15~30 parts Rhizoma Coptidis, preferably 19~25 parts, more preferably 22 parts.In the present invention, described Rhizoma Coptidis heat clearing and damp drying, eliminating fire and detoxication, for wet Fullness-oppression in the epigastrium caused by heat is full, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, and heat in blood is told nosebleed, conjunctival congestion, toothache, quenched one's thirst, Carbuncle furuncle;External treatment eczema, eczema, auditory meatus is suppurated.The source of described Rhizoma Coptidis is not particularly limited by the present invention, uses this area The commercial goods of the Rhizoma Coptidis known to technical staff.
Raw material in a kind of Chinese medicine composition preventing and treating infectious bovine rhinotrachetis that the present invention provides includes 15~25 parts Radix Platycodonis, preferably 16~20 parts, more preferably 17 parts.In the present invention, described Radix Platycodonis lung qi dispersing, sore-throat relieving, eliminate the phlegm, evacuation of pus.For Cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.The source of described Radix Platycodonis is not had by the present invention Particular restriction, uses the commercial goods of Radix Platycodonis well-known to those skilled in the art.
Raw material in a kind of Chinese medicine composition preventing and treating infectious bovine rhinotrachetis that the present invention provides includes 30~40 parts Fructus Forsythiae, preferably 32~35 parts, more preferably 33 parts.In the present invention, described Fructus Forsythiae heat clearing away, removing toxic substances, eliminating stagnation, detumescence, control temperature Heat, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.The source of described Fructus Forsythiae is not particularly limited by the present invention, uses this The commercial goods of the Fructus Forsythiae known to skilled person.
Raw material in a kind of Chinese medicine composition preventing and treating infectious bovine rhinotrachetis that the present invention provides includes 18~25 parts Herba Menthae, preferably 19~23 parts, more preferably 20 parts.In the present invention, described Herba Menthae can alleviate stomachache, gallbladder problem such as convulsion Contraction, also have antisepsis and sterilization, diuresis, reduce phlegm, stomach invigorating and the effect such as aid digestion, a large amount of edible Herba Menthaes may result in insomnia, but little dose Amount is edible but to conduce to sleep.The source of described Herba Menthae is not particularly limited by the present invention, uses those skilled in the art institute ripe The commercial goods of the Herba Menthae known.
Raw material in a kind of Chinese medicine composition preventing and treating infectious bovine rhinotrachetis that the present invention provides includes 25~32 parts Herba Schizonepetae, preferably 27~30 parts, more preferably 28 parts.In the present invention, described Herba Schizonepetae induces sweat scattered wind, and rash, disappear skin ulcer.This Invent the source to described Herba Schizonepetae to be not particularly limited, use the commercial goods of Herba Schizonepetae well-known to those skilled in the art ?.
Raw material in a kind of Chinese medicine composition preventing and treating infectious bovine rhinotrachetis that the present invention provides includes 15~20 parts Herba Ephedrae, preferably 16~19 parts, more preferably 18 parts.In the present invention, described Herba Ephedrae has diaphoresis cold expelling, depressed lung-energy dispersing, diuretic Effect of detumescence, can treat anemofrigid cold, the diseases such as edema due to wind pathogen edema, bronchial asthma of breathing with cough uncomfortable in chest.The present invention is to described Herba Ephedrae Source be not particularly limited, use the commercial goods of Herba Ephedrae well-known to those skilled in the art.
Raw material in a kind of Chinese medicine composition preventing and treating infectious bovine rhinotrachetis that the present invention provides includes 18~25 parts Radix Puerariae, preferably 20~24 parts, more preferably 22 parts.In the present invention, described Radix Puerariae has an expelling pathogenic factors from muscles for reducing heat, rash, promoting the production of body fluid to quench thirst, The merit of yang invigorating antidiarrheal.Being usually used in exterior syndrome heating, stiff nape and back, measles without adequate eruption, calentura is thirsty, and the deficiency of YIN is quenched one's thirst, diarrhea of heat type hematodiarrhoea, insufficiency of the spleen Have loose bowels.The source of described Radix Puerariae is not particularly limited by the present invention, uses the commercially available of Radix Puerariae well-known to those skilled in the art Commodity.
Raw material in a kind of Chinese medicine composition preventing and treating infectious bovine rhinotrachetis that the present invention provides includes 25~35 parts Radix Glycyrrhizae, preferably 28~32 parts, more preferably 30 parts.In the present invention, described Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, only eliminates the phlegm Cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.The source of described Radix Glycyrrhizae is not particularly limited by the present invention, uses those skilled in the art institute Known to the commercial goods of Radix Glycyrrhizae.
In the present invention, the preparation method of described Chinese medicine composition preferably includes following steps:
Crude drug described in technique scheme is pulverized;
Crude drug after described pulverizing is mixed with water, heating and cooking, obtain Chinese medicine composition.
In the present invention, the method for described pulverizing is not particularly limited, and uses pulverizing well-known to those skilled in the art Technical scheme.Granularity after described pulverizing is preferably 50~100 mesh.
In the present invention, the quality of described crude drug and the volume ratio of water are preferably 1g:(4~6) ml, more preferably 1g: 5ml。
In the present invention, the temperature of described heating and cooking is preferably 80~100 DEG C, more preferably 85~95 DEG C, most preferably 90℃.In the present invention, the time of described heating and cooking is preferably 15~30min, more preferably 20~25min.
Chinese medicine composition provided by the present invention has heat-clearing and toxic substances removing, sore-throat relieving dissipates swollen and effect of invigorating the spleen and replenishing QI, based on this One effect provides the application in preparation prevents and treats the medicine of infectious bovine rhinotrachetis of the described Chinese medicine composition.
The described Chinese medicine composition that the present invention provides application in preparation prevents and treats the medicine of infectious bovine rhinotrachetis, Its application has good effect, instant effect, the feature that cure rate is high.
In the present invention, described infectious bovine rhinotrachetis is caused by intestinal I type bovine herpes virus.
Present invention also offers a kind of medicine preventing and treating infectious bovine rhinotrachetis, including Chinese medicine composition and medically connect The adjuvant being subject to, described Chinese medicine composition is Chinese medicine composition of the present invention.
In the present invention, the dosage form of described medicine is preferably oral agents.
In the present invention, in described oral agents Chinese medicine composition aqueous extract each take effective dose be 200~ 300ml.Final volume is raw material of Chinese medicine weight 2~3 times of described Chinese medicine composition aqueous extract.
In the present invention, the time that described oral agents is preferably administered when application continues three to five days, every day 2 times.
A kind of Chinese medicine composition preventing and treating infectious bovine rhinotrachetis of the present invention being provided below in conjunction with embodiment and Application is described in detail, but they can not be interpreted as limiting the scope of the present invention.
Embodiment 1
Weigh the crude drug of following weight portion: Lasiosphaera Seu Calvatia 15g, Fructus Arctii 35g, Radix Scrophulariae 25g, Radix Bupleuri 25g, Radix Isatidis 25g, rise Fiber crops 15g, Radix Scutellariae 34g, Rhizoma Coptidis 15g, Radix Platycodonis 25g, Fructus Forsythiae 30g, Herba Menthae 25g, Herba Schizonepetae 25g, Herba Ephedrae 15g, Radix Puerariae 25g, Radix Glycyrrhizae 25g.After being mixed by the above-mentioned raw materials medicine weighed, to smash into the crude drug that granularity is 80 mesh unqualified, will obtain crude drug unqualified by Mix with water according to the ratio that w/v is 1:4, boiling under the conditions of 100 DEG C, terminate wait boiling when solution reaches 500ml, The supernatant obtained after filtration is Chinese medicine composition.
Embodiment 2
Weigh the crude drug of following weight portion: Lasiosphaera Seu Calvatia 25g, Fructus Arctii 25g, Radix Scrophulariae 35g, Radix Bupleuri 35g, Radix Isatidis 15g, rise Fiber crops 24g, Radix Scutellariae 25g, Rhizoma Coptidis 30g, Radix Platycodonis 15g, Fructus Forsythiae 40g, Herba Menthae 18g, Herba Schizonepetae 32g, Herba Ephedrae 20g, Radix Puerariae 18g, Radix Glycyrrhizae 35g.After being mixed by the above-mentioned raw materials medicine weighed, to smash into the crude drug that granularity is 50 mesh unqualified, will obtain crude drug unqualified by Mix with water according to the ratio that w/v is 1:5, boiling under the conditions of 90 DEG C, terminate wait boiling when solution reaches 600ml, mistake The supernatant obtained after filter is Chinese medicine composition.
Embodiment 3
Weigh the crude drug of following weight portion: Lasiosphaera Seu Calvatia 18g, Fructus Arctii 30g, Radix Scrophulariae 27g, Radix Bupleuri 30g, Radix Isatidis 18g, rise Fiber crops 20g, Radix Scutellariae 28g, Rhizoma Coptidis 25g, Radix Platycodonis 16g, Fructus Forsythiae 35g, Herba Menthae 19g, Herba Schizonepetae 30g, Herba Ephedrae 16g, Radix Puerariae 24g, Radix Glycyrrhizae 28g.After being mixed by the above-mentioned raw materials medicine weighed, to smash into the crude drug that granularity is 60 mesh unqualified, will obtain crude drug unqualified by Mix with water according to the ratio that w/v is 1:5, boiling under the conditions of 100 DEG C, terminate wait boiling when solution reaches 550ml, The supernatant obtained after filtration is Chinese medicine composition.
Embodiment 4
Weigh the crude drug of following weight portion: Lasiosphaera Seu Calvatia 22g, Fructus Arctii 26g, Radix Scrophulariae 30g, Radix Bupleuri 26g, Radix Isatidis 23g, rise Fiber crops 16g, Radix Scutellariae 32g, Rhizoma Coptidis 19g, Radix Platycodonis 20g, Fructus Forsythiae 32g, Herba Menthae 23g, Herba Schizonepetae 27g, Herba Ephedrae 19g, Radix Puerariae 20g, Radix Glycyrrhizae 32g.Smash into, after being mixed by the above-mentioned raw materials medicine weighed, the crude drug that granularity is 100 mesh unqualified, crude drug will be obtained unqualified Mix with water according to the ratio that w/v is 1:6, boiling under the conditions of 95 DEG C, terminate wait boiling when solution reaches 500ml, The supernatant obtained after filtration is Chinese medicine composition.
Embodiment 5
Weigh the crude drug of following weight portion: Lasiosphaera Seu Calvatia 20g, Fructus Arctii 28g, Radix Scrophulariae 28g, Radix Bupleuri 27g, Radix Isatidis 20g, rise Fiber crops 18g, Radix Scutellariae 30g, Rhizoma Coptidis 22g, Radix Platycodonis 17g, Fructus Forsythiae 33g, Herba Menthae 20g, Herba Schizonepetae 28g, Herba Ephedrae 18g, Radix Puerariae 22g, Radix Glycyrrhizae 30g.After being mixed by the above-mentioned raw materials medicine weighed, to smash into the crude drug that granularity is 90 mesh unqualified, will obtain crude drug unqualified by Mix with water according to the ratio that w/v is 1:5, boiling under the conditions of 100 DEG C, terminate wait boiling when solution reaches 600ml, The supernatant obtained after filtration is Chinese medicine composition.
Embodiment 6
Within 2012, there is infectious bovine rhinotrachetis 55 in Zhangye City of Gansu cattle plant, in embodiment 1 being obtained Drug composition is for the treatment of the cattle that falls ill, and the characteristic symptoms such as cattle has dyspnea, nasal cavity is suppurated of falling ill, in conjunction with epidemic diseases Learn, make and be diagnosed as infectious bovine rhinotrachetis, the traditional Chinese medicine composition for treating prepared by the embodiment of the present invention 1, continuous three It is administered, at two days every day, the Chinese medicine composition that each 300ml obtains.There are 55 cattle disease symptoms to disappear after treatment, control completely More, cure rate 100%.
Embodiment 7
Within 2012, there is infectious bovine rhinotrachetis 54 in Zhangye City of Gansu cattle plant, in embodiment 2 being obtained Drug composition is for the treatment of the cattle that falls ill, and the characteristic symptoms such as cattle has dyspnea, nasal cavity is suppurated of falling ill, in conjunction with epidemic diseases Learn, make and be diagnosed as infectious bovine rhinotrachetis, the traditional Chinese medicine composition for treating prepared by the embodiment of the present invention 1, continuous four It is administered, at two days every day, the Chinese medicine composition that each 250ml obtains.There are 54 cattle disease symptoms to disappear after treatment, control completely More, cure rate 100%.
Embodiment 8
Within 2013, infectious bovine rhinotrachetis 75, morbidity cattle is occurred to have nasal mucosa and fill in Zhangye City of Gansu plant Blood, pustule, dyspnea, nasal cavity such as are suppurated at the characteristic symptom, in conjunction with epidemiology, diagnosable for infectious bovine rhinotrachetis, Using the traditional Chinese medicine composition for treating that the embodiment of the present invention 3 prepares, treatment in continuous five days, at two days every day, each 250ml obtains Chinese medicine composition.Treat rear 74 cattle disease symptoms to disappear, cure completely, cure rate 98.7%.
Embodiment 9
Within 2013, infectious bovine rhinotrachetis 61, morbidity cattle is occurred to have nasal mucosa and fill in plant of Gansu Wuwei city Blood, pustule, dyspnea, nasal cavity such as are suppurated at the characteristic symptom, in conjunction with epidemiology, diagnosable for infectious bovine rhinotrachetis, Using the traditional Chinese medicine composition for treating of the embodiment of the present invention 4 preparation, continuous four treat everyday, and at two days every day, each 300ml obtains Chinese medicine composition.Treat rear 60 cattle disease symptoms to disappear, cure completely, cure rate 98.4%.
Embodiment 10
Within 2013, infectious bovine rhinotrachetis 61, morbidity cattle is occurred to have nasal mucosa and fill in plant of Gansu Wuwei city Blood, pustule, dyspnea, nasal cavity such as are suppurated at the characteristic symptom, in conjunction with epidemiology, diagnosable for infectious bovine rhinotrachetis, Using the traditional Chinese medicine composition for treating of the embodiment of the present invention 5 preparation, continuous four treat everyday, and at two days every day, each 250ml obtains Chinese medicine composition.Treat rear 61 cattle disease symptoms to disappear, cure completely, cure rate 100%.
As seen from the above embodiment, a kind of Chinese medicine composition preventing and treating infectious bovine rhinotrachetis that the present invention provides, will Plurality of Chinese compounds the Chinese medicine composition of formation and has heat-clearing and toxic substances removing, sore-throat relieving dissipates swollen, the effect of invigorating the spleen and replenishing QI, thus the work of Chinese medicine Property material goes directly focus.Chinese medicine composition of the present invention has curative effect in the application prevent and treat infectious bovine rhinotrachetis Good, instant effect, the feature that cure rate is high.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art For Yuan, under the premise without departing from the principles of the invention, it is also possible to make some improvements and modifications, these improvements and modifications also should It is considered as protection scope of the present invention.

Claims (7)

1. prevent and treat a Chinese medicine composition for infectious bovine rhinotrachetis, including the crude drug of following weight portion: Lasiosphaera Seu Calvatia 15~25 Part, Fructus Arctii 25~35 parts, Radix Scrophulariae 25~35 parts, Radix Bupleuri 25~35 parts, Radix Isatidis 15~25 parts, Rhizoma Cimicifugae 15~24 parts, Radix Scutellariae 25~34 parts, Rhizoma Coptidis 15~30 parts, Radix Platycodonis 15~25 parts, Fructus Forsythiae 30~40 parts, Herba Menthae 18~25 parts, Herba Schizonepetae 25~32 parts, Herba Ephedrae 15~20 parts, Radix Puerariae 18~25 parts, Radix Glycyrrhizae 25~35 parts.
Chinese medicine composition the most according to claim 1, including the crude drug of following weight portion: Lasiosphaera Seu Calvatia 18~22 parts, Fructus Arctii Son 26~30 parts, Radix Scrophulariae 27~30 parts, Radix Bupleuri 26~30 parts, Radix Isatidis 18~23 parts, Rhizoma Cimicifugae 16~20 parts, Radix Scutellariae 28~32 Part, Rhizoma Coptidis 19~25 parts, Radix Platycodonis 16~20 parts, Fructus Forsythiae 32~35 parts, Herba Menthae 19~23 parts, Herba Schizonepetae 27~30 parts, Herba Ephedrae 16 ~19 parts, Radix Puerariae 20~24 parts, Radix Glycyrrhizae 28~32 parts.
Chinese medicine composition the most according to claim 1 and 2, including the crude drug of following weight portion: Lasiosphaera Seu Calvatia 20 parts, Fructus Arctii 28 parts, Radix Scrophulariae 28 parts, Radix Bupleuri 27 parts, Radix Isatidis 20 parts, Rhizoma Cimicifugae 18 parts, Radix Scutellariae 30 parts, Rhizoma Coptidis 22 parts, Radix Platycodonis 17 parts, Fructus Forsythiae 33 Part, Herba Menthae 20 parts, Herba Schizonepetae 28 parts, 18 parts of Herba Ephedrae, Radix Puerariae 22 parts, 30 parts of Radix Glycyrrhizae.
4. the Chinese medicine composition described in claims 1 to 3 any one is in preparation prevents and treats the medicine of infectious bovine rhinotrachetis Application.
Application the most according to claim 4, it is characterised in that described infectious bovine rhinotrachetis is by intestinal I type cattle herpes Virus causes.
6. prevent and treat a medicine for infectious bovine rhinotrachetis, including Chinese medicine composition and the adjuvant that pharmaceutically accepts, described in Drug composition is the Chinese medicine composition described in claims 1 to 3 any one.
Medicine the most according to claim 6, it is characterised in that the dosage form of described medicine is oral agents.
CN201610724350.1A 2016-08-25 2016-08-25 A kind of Chinese medicine composition preventing and treating infectious bovine rhinotrachetis and application thereof Pending CN106177156A (en)

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CN109550041A (en) * 2019-01-11 2019-04-02 山东省农业科学院奶牛研究中心 Application of the oritavancin phosphate in preparation prevention and treatment infectious bovine rhinotrachetis drug
CN109646435A (en) * 2019-01-11 2019-04-19 山东省农业科学院奶牛研究中心 Application of the ertapenem in preparation prevention and treatment infectious bovine rhinotrachetis drug

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Publication number Priority date Publication date Assignee Title
CN109550041A (en) * 2019-01-11 2019-04-02 山东省农业科学院奶牛研究中心 Application of the oritavancin phosphate in preparation prevention and treatment infectious bovine rhinotrachetis drug
CN109646435A (en) * 2019-01-11 2019-04-19 山东省农业科学院奶牛研究中心 Application of the ertapenem in preparation prevention and treatment infectious bovine rhinotrachetis drug
CN109646435B (en) * 2019-01-11 2021-08-03 山东省农业科学院奶牛研究中心 Application of ertapenem sodium in preparation of medicine for preventing and treating infectious bovine rhinotracheitis
CN109550041B (en) * 2019-01-11 2021-09-10 山东省农业科学院奶牛研究中心 Application of oritavancin phosphate in preparation of medicine for preventing and treating infectious bovine rhinotracheitis

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Application publication date: 20161207