CN101829188B - Medicament for treating urinary infection and lithiasis - Google Patents

Abstract

The invention relates to a medicament for treating urinary infection and lithiasis, which is prepared from the following medicinal materials in parts by weight: 1-5 parts of aspidopterys glabriuscula, 1-3 parts of wild reed cereal roots, 1-3 parts of conical celastrus orbiculatus, 1-3 parts of folium orthosiphoni and 1-2 parts of liquorice. The medicament is used for treating acute and chronic nephritis, pyelitis, urinary tract infection, renal calculi, ureter calculi, bladder calculi and the like; the medicament prepared into different preparations by applying the modern technique is applied in clinics to obtain an obvious therapeutic effect, and the research on the main pharmacodynamics proves that the medicament has no toxic or side reaction, safe and has reliable and obvious therapeutic effect, good development and application prospect and market competitiveness through clinical therapeutic effect observation and urgent toxin test.

Description

A kind of treatment urinary system infection and Iithiasic medicine

Technical field

The present invention relates to a kind of preparation technology who is used to treat urinary system infection and Iithiasic medicine and this medicine.

Background technology

Existing treatment urinary system infection and the most DeGrain of Iithiasic Chinese medicine composition, what have also has certain therapeutic effect, but most of herbal prescription exist safe and reliable relatively poor between topic, what have also has big toxic and side effects.

It is long-pending hot in interior that urinary system infection and calculus, the Dai nationality's medical science think that occuring as of primary disease liked the fragrant scorching article of food usually, and body endogenous fire tower is contained partially; To infect external hot blast poison evil in addition, inside and outside be harmonious and accumulate long-pending lower wall, the damage water tower; Water tower is not enough, can not make fire, and pathogenic fire is crossed to contain and burnt bladder and hyperamization urine, hematuria, chyluria, pyuria, yellow urine; Decoct urine, the husky urine of urine simmer down to stone.The hot puckery pain of clinical visible urine, it is not well to drench drop, drop and descend, lower abdomen contracture dragging pain or frequency are anxious bloated, carry sandstone during urine secretly.Treatment should be with the detoxifcation of relieving inflammation or internal heat, diuresis fossil for controlling.

Summary of the invention

The objective of the invention is to propose treatment urinary system infection and the Iithiasic medicine that a kind of drug effect is high, cost is low, the course of treatment is short, easy to use, to solve the deficiency of prior art.

This treatment urinary system infection and Iithiasic medicine that the present invention proposes are processed by the medical material of following weight parts: Caulis Aspidopterydis obcordatae 1-5, YELUGUGEN 1-3, Celastrus Paniculatus Willd 1-3, kidney tea 1-3, Radix Glycyrrhizae 1-2.

Caulis Aspidopterydis obcordatae, YELUGUGEN, cool in nature in the prescription, entry, Tu Ta have heat-clearing and toxic substances removing, and the merit of diuresis fossil cures mainly the hot puckery pain of urine, and the disease of carrying sandstone secretly is principal agent; Kidney tea, Celastrus Paniculatus Willd have heat-clearing and toxic substances removing, promoting urination and stopping pain, and the merit of cooling blood for hemostasis helps principal agent to strengthen the power of diuresis detoxifcation, is adjuvant altogether; Radix Glycyrrhizae can help main and auxiliary medicine to heighten the effect of a treatment, again can the side of system in cold and cool diuretic medicine numbness and coordinating the actions of various ingredients in a prescription is harmonizing drug.Full side share, and brings into play heat-clearing and toxic substances removing jointly, diuresis fossil, the effect of cooling blood for hemostasis.

After allotment on the basis of above-mentioned prescription, can also add Herba Lysimachiae and constitute prescription two, both can strengthen the power of heat-clearing and toxic substances removing, also can accelerate diuresis fossil calculus speed.

On the basis of above-mentioned two prescriptions, also can add Endothelium Corneum Gigeriae Galli and Viburnum cylindricum, treat the exaggerate heresy of the external pyretic toxicity of multiple sense of pyretic toxicity in the body with the power that strengthens heat clearing away pyretic toxicity, diuresis fossil, inside and outside be harmonious and the serious urinary system infection and the calculus that cause.

The medicine of the present invention's preparation is used to treat acute and chronic nephritis, pyelitis, urinary tract infection, diseases such as kidney, ureter, vesical calculus.Applicating modern times technology is developed into different dosage forms and is applied to clinically, receives significant curative effect.

This medicine has been accomplished corresponding research work according to the requirement of national drug administrative law hospital preparation registration, proves through clinical observation on the therapeutic effect and anxious malicious experimental study; Do not find toxicity; Curative effect is safe and reliable, and is evident in efficacy, has the good development prospect and the market competitiveness.

Through 203 routine patients having been carried out the observation of clinical efficacy, its total effective rate is 86.35%.Wherein: urinary system infection 141, produce effects 79 examples, effective 51 examples, invalid 11 examples, effective percentage is 92.1%; Urinary system calculus 62 examples, produce effects 37 examples, effective 14 examples, invalid 11 examples, effective percentage is 80.6%.

The specific embodiment

Embodiment 1, a kind of treatment urinary system infection and Iithiasic medicine, process by the medical material of following weight parts:

Caulis Aspidopterydis obcordatae 1-5, YELUGUGEN 1-3, Celastrus Paniculatus Willd 1-3, kidney tea 1-3, Radix Glycyrrhizae 1-2.

The step of preparation process of medicine is following:

1), get Caulis Aspidopterydis obcordatae, YELUGUGEN and Celastrus Paniculatus Willd, add decocting in water and carry three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, merges filtrating three times, filter, filtrating is concentrated into relative density 1.3～1.35, gets extractum, subsequent use;

2) get surplus medicine kidney tea became 100 mesh sieves with the Radix Glycyrrhizae pulverize separately fine powder, again, mixing is subsequent use;

3), with 1) step gained extractum and 2) step gained fine powder mixing; In 60 ℃ ± 5 ℃ temperature after the drying; Pulverized 100 mesh sieves, processed capsule, tablet, pill, powder or granule with corresponding pharmaceutic adjuvant with 70%～90% alcohol granulation, sterilization back.

Embodiment 2, a kind of treatment urinary system infection and Iithiasic medicine, process by the medical material of following weight parts:

Caulis Aspidopterydis obcordatae 1-5, YELUGUGEN 1-3, Celastrus Paniculatus Willd 1-3, kidney tea 1-3, Radix Glycyrrhizae 1-2, Herba Lysimachiae 1-3.

The step of preparation process of decoction is following:

Get Caulis Aspidopterydis obcordatae, YELUGUGEN, Celastrus Paniculatus Willd, kidney tea, Radix Glycyrrhizae and Herba Lysimachiae, add water to and flood medicine 10-15 centimetre, soak half an hour after; Decoct three times, for the first time, boiled 30 minutes; Second and third time all adds boiled water to flat medicinal residues, respectively boils 30 minutes, merges three times decocting liquid.

Instructions of taking: decoction being taken warmly, obey 200ml, every day three times at every turn.

Also can combine the modern pharmaceutical technology to process other dosage form, step of preparation process is following:

1), get Caulis Aspidopterydis obcordatae, YELUGUGEN, Celastrus Paniculatus Willd and Herba Lysimachiae, add decocting in water and carry three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, merges filtrating three times, filter, filtrating is concentrated into relative density 1.3～1.35, gets extractum, subsequent use;

2) get surplus medicine kidney tea became 100 mesh sieves with the Radix Glycyrrhizae pulverize separately fine powder, again, mixing is subsequent use;

3), with 1) step gained extractum and 2) step gained fine powder mixing; In 60 ℃ ± 5 ℃ temperature after the drying; Pulverized 100 mesh sieves, processed capsule, tablet, pill, powder or granule with corresponding pharmaceutic adjuvant with 70%～90% alcohol granulation, sterilization back.

Embodiment 3, a kind of treatment urinary system infection and Iithiasic medicine, process by the medical material of following weight parts:

Caulis Aspidopterydis obcordatae 1-5, YELUGUGEN 1-3, Celastrus Paniculatus Willd 1-3, Endothelium Corneum Gigeriae Galli 1-5, kidney tea 1-3, Herba Lysimachiae 1-3, Viburnum cylindricum 1-3, Radix Glycyrrhizae 1-2.

The step of preparation process of decoction is following:

Get Caulis Aspidopterydis obcordatae, YELUGUGEN, Celastrus Paniculatus Willd, Endothelium Corneum Gigeriae Galli, kidney tea, Herba Lysimachiae, Viburnum cylindricum and Radix Glycyrrhizae, add water to and flood medicine 10-15 centimetre, soak half an hour after; Decoct three times; For the first time, boiled 30 minutes, second and third time all adds boiled water to flat medicinal residues; Respectively boiled 30 minutes, and merged three times decocting liquid.

Instructions of taking: decoction being taken warmly, obey 200ml, every day three times at every turn.

Also can combine the modern pharmaceutical technology to process other dosage form, step of preparation process is following:

1), get Caulis Aspidopterydis obcordatae, YELUGUGEN, Celastrus Paniculatus Willd, Herba Lysimachiae and Viburnum cylindricum and add decocting in water and carry three times, 2 hours for the first time, 1.5 hours for the second time; 1 hour for the third time, merge filtrating three times, filter; Filtrating is concentrated into relative density 1.3～1.35, gets extractum, and is subsequent use;

2) get surplus medicine kidney tea, Endothelium Corneum Gigeriae Galli and Radix Glycyrrhizae pulverize separately, again to the fine powder of crossing 100 mesh sieves, mixing is subsequent use;

3), with 1) step gained extractum and 2) step gained fine powder mixing; In 60 ℃ ± 5 ℃ temperature after the drying; Pulverized 100 mesh sieves, processed capsule, tablet, pill, powder or granule with corresponding pharmaceutic adjuvant with 70%～90% alcohol granulation, sterilization back.

Medicine according to the foregoing description 1-3 preparation is safe and reliable through acute toxicity test and long term toxication proof curative effect, and result of the test is following:

Experiment purpose: the acute toxic reaction of observing the mice oral drug;

Experiment material: (1) medicine: doctor hospital of Xishuangbanna Dai Nationality provides; Get this fine drug powder powder 20g, add water and process 32ml suspension confession experiment usefulness; (2) animal: cleaning level ICR mice, 18-22g, male and female half and half are provided by unming Medical College.The quality certification number: No. the 9806th, the moving pipe of cloud.

Experimental technique: these article medicine can not surveyed the LD of oral administration through prerun ₅₀So, carry out maximum tolerance determination.Get 20 of body weight 20 ± 2g mices, male and female half and half, fasting was pressed 40ml/Kg with above-mentioned medicinal liquid after 12 hours, irritated the stomach secondary in one day, 6 hours at interval, observed continuously then 7 days.

Experimental result: irritate stomach amount 0.4ml/10g to calculate dosage is 62.4g crude drug/Kg by maximum concentration 0.78g crude drug/ml and mice are maximum, calculate, 115 times of usual amounts 0.54g crude drug/Kg every day that is equivalent to be grown up by kg body weight; Press body surface area coefficient conversion, be equivalent to more than 12 times of 70Kg body weight adult usual amounts every day, none is dead and poison in 20 mices 7 days.The maximum tolerated dose of these article of mouse stomach medicine is 62.4g crude drug/Kg, proves that the safety of these article drug oral is higher.

Claims (2)

1. treat urinary system infection and Iithiasic medicine for one kind, it is characterized in that processing by the medical material of following weight parts:

Caulis Aspidopterydis obcordatae 1-5, YELUGUGEN 1-3, Celastrus Paniculatus Willd 1-3, kidney tea 1-3, Radix Glycyrrhizae 1-2.

2. the preparation technology of treatment urinary system infection according to claim 1 and Iithiasic medicine is characterized in that step is following:

1), get Caulis Aspidopterydis obcordatae, YELUGUGEN and Celastrus Paniculatus Willd, add decocting in water and carry three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, merges filtrating three times, filter, filtrating is concentrated into relative density 1.3 ~ 1.35, gets extractum, subsequent use;

2) get surplus medicine kidney tea became 100 mesh sieves with the Radix Glycyrrhizae pulverize separately fine powder, again, mixing is subsequent use;

3), with 1) step gained extractum and 2) step gained fine powder mixing; In 60 ℃ ± 5 ℃ temperature after the drying; Pulverized 100 mesh sieves, processed capsule, tablet, pill, powder or granule with corresponding pharmaceutic adjuvant with 70%～90% alcohol granulation, sterilization back.