CN101983666A - Traditional Chinese medicine composition for treating rheumatism and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating rheumatism and preparation method thereof Download PDFInfo
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- CN101983666A CN101983666A CN2010105450054A CN201010545005A CN101983666A CN 101983666 A CN101983666 A CN 101983666A CN 2010105450054 A CN2010105450054 A CN 2010105450054A CN 201010545005 A CN201010545005 A CN 201010545005A CN 101983666 A CN101983666 A CN 101983666A
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Abstract
The invention relates to an oral traditional Chinese medicine preparation, in particular to a traditional Chinese medicine composition for treating rheumatism and a preparation method thereof. The composition is characterized by being prepared from the following traditional Chinese medicines by weight: 10-20 parts of kadsura pepper stem, 10-20 parts of erythrinae cortex, 5-15 parts of frankincense, 5-15 parts of myrrh, 3-10 parts of saffron, 5-15 parts of peach kernels, 5-15 parts of szechwan chinaberry fruit, 10-20 parts of angelica sinensis, 10-15 parts of red paeony root and 5-15 parts of eucommia bark. The composition can rapidly relieve pain, has the functions of diminishing inflammation and dissipating blood stasis, has confirmed curative effect on treating rheumatism and has no toxic or side effects.
Description
Technical field
The present invention relates to a kind of oral Chinese medicine preparation, rheumatismal Chinese medicine composition of particularly a kind of treatment and preparation method thereof.
Background technology
Rheumatism refers to mainly invade joint, muscle, skeleton, reaches periarticular soft tissue, as the disease at positions such as tendon, ligament, synovial bursa, fascia.
According to investigations, the rheumatismal medicine of general treatment need be taken for a long time on the market, spending everyday, effect neither be clearly, some Western medicine even patient body is had very big harm (containing hormone) conventional therapy all is control and the treatment pattern kept,--development and the deterioration of conditions of patients can not be effectively controlled in the vicious cycle that takes a turn for the better--drug withdrawal---recur, and cause the generation of " rheumatic nephropathy " complication such as " rheumatic heart diseases " in medication.
Summary of the invention
The object of the present invention is to provide rheumatismal Chinese medicine composition of a kind of treatment and preparation method thereof, it can be behind oral this Chinese medicine composition of patient side effect little, good effect.
Technical scheme of the present invention is: the rheumatismal oral Chinese medicine compositions of a kind of treatment is characterized in that: the raw material of Chinese medicine medicine by following weight parts is formulated:
Caulis Piperis Kadsurae 10-20 part, Cortex erythrinae 10-20 part, Olibanum 5-15 part, Myrrha 5-15 part, Stigma Croci 3-10 part, Semen Persicae 5-15 part, Fructus Toosendan 5-15 part, Radix Angelicae Sinensis 10-20 part, Radix Paeoniae Rubra 10-15 part, Cortex Eucommiae 5-15 part.
Described a kind of weight portion for the treatment of rheumatismal oral Chinese medicine compositions is: 15 parts of Caulis Piperis Kadsuraes, 15 parts of Cortex erythrinaes, 10 parts of Olibanums, 10 parts of Myrrhas, 6 parts of Stigma Crocis, 10 parts in Semen Persicae, 10 parts of Fructus Toosendans, 15 parts of Radix Angelicae Sinensis, 12 parts of Radix Paeoniae Rubra, 10 parts of the Cortexs Eucommiae.
Described a kind of weight portion for the treatment of rheumatismal oral Chinese medicine compositions is: 10 parts of Caulis Piperis Kadsuraes, 10 parts of Cortex erythrinaes, 5 parts of Olibanums, 5 parts of Myrrhas, 3 parts of Stigma Crocis, 5 parts in Semen Persicae, 5 parts of Fructus Toosendans, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Paeoniae Rubra, 5 parts of the Cortexs Eucommiae.
Described a kind of weight portion for the treatment of rheumatismal oral Chinese medicine compositions is: 20 parts of Caulis Piperis Kadsuraes, 20 parts of Cortex erythrinaes, 15 parts of Olibanums, 15 parts of Myrrhas, 10 parts of Stigma Crocis, 15 parts in Semen Persicae, 15 parts of Fructus Toosendans, 20 parts of Radix Angelicae Sinensis, 15 parts of Radix Paeoniae Rubra, 15 parts of the Cortexs Eucommiae.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, comprises the steps:
1), the crude drug got in the above-mentioned raw materials carries out roguing respectively, and clean, dry, standby;
2), in the above raw material, Olibanum, Myrrha are ground into 100 order fine powders, standby;
3), all the other 8 kinds of crude drug are mixed, and the decocting that adds 10 times of amounts boils, and decocts 2 hours after-filtration, filtrate for later use;
4), the medicinal residues that step 3) the is obtained decocting that adds 8 times of amounts again boils 2 hours after-filtration, filtrate for later use;
5), with step 3), 4) filtrate that obtains mixing be incorporated in 60 ℃ and be evaporated to the thick paste that relative density is 1.15-1.25, and be standby;
6), with step 2) thick paste mix homogeneously that the fine powder that obtains and step 6) obtain, drying is ground into fine powder, makes described Chinese medicine composition.
Described fine powder all can pass through 100 mesh sieves, wherein is no less than 95% and can passes through 125 mesh sieves.
Preparation of the present invention is peroral dosage form preferably, as: capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation unguentum etc., more preferably capsule.Preparation of the present invention is determined usage and dosage according to patient's situation in use.
Every of this medicament specification contains active ingredient 0.9g, oral one time 5,2 times on the 1st, serveing on for 4 weeks was 1 course of treatment.
Characteristics of the present invention are: this Chinese medicine composition contains Caulis Piperis Kadsurae, Cortex erythrinae, Olibanum, Myrrha, Stigma Croci, Semen Persicae, Fructus Toosendan, Radix Angelicae Sinensis, Radix Paeoniae Rubra, the Cortex Eucommiae.Be that clinical treatment experience and verification experimental verification " book on Chinese herbal medicine cover bamboo fish trap " note has that " Radix Angelicae Sinensis can removing blood stasis blood, and tissue regeneration promoting blood makes unobstructed vessel.Parallel with gas, flow round without stopping ".And prescription, have invigorate blood circulation, the effect of promoting the circulation of QI, removing obstruction in the collateral to relieve pain.The side is classified as monarch to work as, with its hot temperature, and the power of nourishing blood and promoting blood circulation, pain relieving, dissipating blood stasis nourishes blood to moisten brain with logical brain venation, and blood stasis goes, and fresh blood is living, and venation is logical, and pain is ended, the full brain of marrow is bright.Compendium of Material Medica is carried: Radix Angelicae Sinensis " is controlled headache, all pains of trusted subordinate, intestine moistening stomach muscles and bones skin "." book on Chinese herbal medicine just " has " so can enrich blood, its gas is light and hot for Radix Angelicae Sinensis, its sweet in the mouth and hardship, again can promoting the circulation of blood, invigorating middle warmer has, in the row benefit is arranged, the panacea in the blood also ".The invigorating the liver and kidney of Cortex Eucommiae tool, bone and muscle strengthening, blood pressure lowering, many effects such as antiabortive." book on Chinese herbal medicine is looked for the truth ": Cortex erythrinae, can go into the Liver Channel blood system, expelling wind and removing dampness, and the network of passing through are to reach disease institute.
Caulis Piperis Kadsurae: Caulis Piperis Kadsurae is risen arduous, the temperature of dispeling the wind, the meridian dredging, stopping numbness pain;
Olibanum: Olibanum is arduous, treats all malignant boil, the granulation promoting pain relieving, and the trusted subordinate is good especially;
Myrrha: Myrrha is bitter flat, controls the skin ulcer pain relieving, traumatic injury, and removing blood stasis is general;
Stigma Croci: Flos Carthami sweet in the mouth, blood circulation promoting and blood stasis dispelling, removing pathogenic heat from blood and toxic substance from the body, resolving stagnation for tranquilization;
Semen Persicae: Semen Persicae sweetness and bitterness, blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma;
Fructus Toosendan: the Fructus Toosendan bitter in the mouth, go into Liver Channel, catharsis liver-heat, promoting the circulation of QI to relieve pain;
Radix Paeoniae Rubra: Radix Paeoniae Rubra bitter in the mouth, clearing away heat and cooling blood, eliminating stasis to stop pain.
The above-mentioned raw materials medicine is made mixing ratio respectively and is mixed together and boils drug effect and improve greatly, and can the fast pain relief sense.The effect that has detumescence, blood stasis dispelling simultaneously, this medicine is used for the treatment of the rheumatism determined curative effect, has no side effect.
The specific embodiment
Below by the specific embodiment that provides the present invention is described clearly further, but not as a limitation of the invention.
Embodiment 1
Described a kind of weight portion for the treatment of rheumatismal oral Chinese medicine compositions is: 15 parts of Caulis Piperis Kadsuraes, 15 parts of Cortex erythrinaes, 10 parts of Olibanums, 10 parts of Myrrhas, 6 parts of Stigma Crocis, 10 parts in Semen Persicae, 10 parts of Fructus Toosendans, 15 parts of Radix Angelicae Sinensis, 12 parts of Radix Paeoniae Rubra, 10 parts of the Cortexs Eucommiae.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, comprises the steps:
1), the crude drug got in the above-mentioned raw materials carries out roguing respectively, and clean, dry, standby;
2), in the above raw material, Olibanum, Myrrha are ground into 100 order fine powders, standby;
3), all the other 8 kinds of crude drug are mixed, and the decocting that adds 10 times of amounts boils, and decocts 2 hours after-filtration, filtrate for later use;
4), the medicinal residues that step 3) the is obtained decocting that adds 8 times of amounts again boils 2 hours after-filtration, filtrate for later use;
5), with step 3), 4) filtrate that obtains mixing be incorporated in 60 ℃ and be evaporated to the thick paste that relative density is 1.15-1.25, and be standby;
6), with step 2) thick paste mix homogeneously that the fine powder that obtains and step 6) obtain, drying is ground into fine powder, makes described Chinese medicine composition.
Embodiment 2
Described a kind of weight portion for the treatment of rheumatismal oral Chinese medicine compositions is: 10 parts of Caulis Piperis Kadsuraes, 10 parts of Cortex erythrinaes, 5 parts of Olibanums, 5 parts of Myrrhas, 3 parts of Stigma Crocis, 5 parts in Semen Persicae, 5 parts of Fructus Toosendans, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Paeoniae Rubra, 5 parts of the Cortexs Eucommiae.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, comprises the steps:
1), the crude drug got in the above-mentioned raw materials carries out roguing respectively, and clean, dry, standby;
2), in the above raw material, Olibanum, Myrrha are ground into 100 order fine powders, standby;
3), all the other 8 kinds of crude drug are mixed, and the decocting that adds 10 times of amounts boils, and decocts 2 hours after-filtration, filtrate for later use;
4), the medicinal residues that step 3) the is obtained decocting that adds 8 times of amounts again boils 2 hours after-filtration, filtrate for later use;
5), with step 3), 4) filtrate that obtains mixing be incorporated in 60 ℃ and be evaporated to the thick paste that relative density is 1.15-1.25, and be standby;
6), with step 2) thick paste mix homogeneously that the fine powder that obtains and step 6) obtain, drying is ground into fine powder, makes described Chinese medicine composition.
Embodiment 3
Described a kind of weight portion for the treatment of rheumatismal oral Chinese medicine compositions is: 20 parts of Caulis Piperis Kadsuraes, 20 parts of Cortex erythrinaes, 15 parts of Olibanums, 15 parts of Myrrhas, 10 parts of Stigma Crocis, 15 parts in Semen Persicae, 15 parts of Fructus Toosendans, 20 parts of Radix Angelicae Sinensis, 15 parts of Radix Paeoniae Rubra, 15 parts of the Cortexs Eucommiae.
The present invention also provides the preparation method of above-mentioned Chinese medicine composition, comprises the steps:
1), the crude drug got in the above-mentioned raw materials carries out roguing respectively, and clean, dry, standby;
2), in the above raw material, Olibanum, Myrrha are ground into 100 order fine powders, standby;
3), all the other 8 kinds of crude drug are mixed, and the decocting that adds 10 times of amounts boils, and decocts 2 hours after-filtration, filtrate for later use;
4), the medicinal residues that step 3) the is obtained decocting that adds 8 times of amounts again boils 2 hours after-filtration, filtrate for later use;
5), with step 3), 4) filtrate that obtains mixing be incorporated in 60 ℃ and be evaporated to the thick paste that relative density is 1.15-1.25, and be standby;
6), with step 2) thick paste mix homogeneously that the fine powder that obtains and step 6) obtain, drying is ground into fine powder, makes described Chinese medicine composition.
More than the prescription effect of three embodiment be more significant prescription, but so long as comparatively significantly curative effect, Caulis Piperis Kadsurae 10-20 part, Cortex erythrinae 10-20 part, Olibanum 5-15 part, Myrrha 5-15 part, Stigma Croci 3-10 part, Semen Persicae 5-15 part, Fructus Toosendan 5-15 part, Radix Angelicae Sinensis 10-20 part, Radix Paeoniae Rubra 10-15 part, Cortex Eucommiae 5-15 part all can be arranged by following prescription proportioning.
The umber of Chinese medicine component can be got gram (g), kilogram (kg), ton (t).
In order to show the therapeutic effect of medicine of the present invention, the present invention has carried out clinical trial.
A kind of clinical trial for the treatment of rheumatismal oral Chinese medicine compositions proposed by the invention is as follows: select age 30-55 year patient 48 examples, 40 years old mean age, course of disease 3-5, average course of disease 4 years.Patient's symptom is more serious, and 18 people of inflammation appear in arthralgia person 20 people, 10 people of erythema occur, and the patient did not accept other treatment before this treatment.30 days is a course of treatment, carries out symptom score after 25 days.Among the 48 routine patients, 12 examples are as treatment group 1, and it adopts medicine of the present invention; Select 12 examples as treatment group 2 again, material component and treatment group 1 that treatment group 2 adopts are the same materials components, and production technology difference, treatment group 2 are first together the mixing together of all material components to be brewed into paste medicine; Select 12 examples A group timing external application Hull gram bone pain medicine plaster in contrast again; 12 examples (being called contrast B group) are used osmanthus dragon ointment; Be careful in one's diet during this time and have a rest.
Observational technique
1. observation index: 1. arthralgia degree, the time, the position, direction changes.2. simultaneous phenomenon (low grade fever, inflammation, eruption).3. symptom influences variations such as weather conditions;
2. efficacy determination: 1. clinical cure: symptom disappears substantially not to be had repeatedly.2. produce effects: pain is obviously alleviated, and simultaneous phenomenon disappears substantially or big portion alleviates, and meets the influence factor and does not have and increase the weight of.3. take a turn for the better: pain and simultaneous phenomenon alleviate, and then increase the weight of but meet the influence factor.4. invalid: all symptoms do not have to alleviate or have and increase the weight of trend.
Therapeutic outcome:
Treat after 25 days, therapeutic effect relatively sees Table 1.
Table 1 unguentum treatment of the present invention effect comparison after 20 days
| Group | Number | Produce effects | Take a turn for the better | 28 days effective percentage |
| Treatment group 1 | 12 | 11 | 10 | 83.3% |
| Treatment group 2 | 12 | 10 | 9 | 75.0% |
| Contrast A group | 12 | 9 | 8 | 66.7% |
| Contrast B group | 12 | 9 | 7 | 58.3% |
By table 1 as seen, the effect of the treatment group 1 of the Chinese medicine that use the present invention is made is apparently higher than treatment group 2, illustrate that production technology has a significant impact therapeutic effect, the effect of treatment group 1 is apparently higher than contrast A group and contrast B group, and symptom takes a turn for the better apparently higher than restraining bone pain medicine plaster and Gui Long ointment with the Hull, the therapeutic effect that shows the powder that use the present invention is made is good, the obvious effective rate height.
Claims (5)
1. treat rheumatismal oral Chinese medicine compositions for one kind, it is characterized in that: the raw material of Chinese medicine medicine by following weight parts is formulated: Caulis Piperis Kadsurae 10-20 part, Cortex erythrinae 10-20 part, Olibanum 5-15 part, Myrrha 5-15 part, Stigma Croci 3-10 part, Semen Persicae 5-15 part, Fructus Toosendan 5-15 part, Radix Angelicae Sinensis 10-20 part, Radix Paeoniae Rubra 10-15 part, Cortex Eucommiae 5-15 part.
2. according to the rheumatismal oral Chinese medicine compositions of the described a kind of treatment of claim 1, it is characterized in that: its weight portion is: 15 parts of Caulis Piperis Kadsuraes, 15 parts of Cortex erythrinaes, 10 parts of Olibanums, 10 parts of Myrrhas, 6 parts of Stigma Crocis, 10 parts in Semen Persicae, 10 parts of Fructus Toosendans, 15 parts of Radix Angelicae Sinensis, 12 parts of Radix Paeoniae Rubra, 10 parts of the Cortexs Eucommiae.
3. according to the rheumatismal oral Chinese medicine compositions of the described a kind of treatment of claim 1, it is characterized in that: its weight portion is: 10 parts of Caulis Piperis Kadsuraes, 10 parts of Cortex erythrinaes, 5 parts of Olibanums, 5 parts of Myrrhas, 3 parts of Stigma Crocis, 5 parts in Semen Persicae, 5 parts of Fructus Toosendans, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Paeoniae Rubra, 5 parts of the Cortexs Eucommiae.
4. according to the rheumatismal oral Chinese medicine compositions of the described a kind of treatment of claim 1, it is characterized in that: 20 parts of Caulis Piperis Kadsuraes, 20 parts of Cortex erythrinaes, 15 parts of Olibanums, 15 parts of Myrrhas, 10 parts of Stigma Crocis, 15 parts in Semen Persicae, 15 parts of Fructus Toosendans, 20 parts of Radix Angelicae Sinensis, 15 parts of Radix Paeoniae Rubra, 15 parts of the Cortexs Eucommiae.
5. according to the rheumatismal oral Chinese medicine preparation of compositions of the described a kind of treatment of claim 1-4 method, comprise the steps:
1), the crude drug got in the above-mentioned raw materials carries out roguing respectively, and clean, dry, standby;
2), in the above raw material, Olibanum, Myrrha are ground into 100 order fine powders, standby;
3), all the other 8 kinds of crude drug are mixed, and the decocting that adds 10 times of amounts boils, and decocts 2 hours after-filtration, filtrate for later use;
4), the medicinal residues that step 3) the is obtained decocting that adds 8 times of amounts again boils 2 hours after-filtration, filtrate for later use;
5), with step 3), 4) filtrate that obtains mixing be incorporated in 60 ℃ and be evaporated to the thick paste that relative density is 1.15-1.25, and be standby;
6), with step 2) thick paste mix homogeneously that the fine powder that obtains and step 6) obtain, drying is ground into fine powder, makes described Chinese medicine composition.
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| CN2010105450054A CN101983666A (en) | 2010-11-16 | 2010-11-16 | Traditional Chinese medicine composition for treating rheumatism and preparation method thereof |
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| CN2010105450054A CN101983666A (en) | 2010-11-16 | 2010-11-16 | Traditional Chinese medicine composition for treating rheumatism and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103877183A (en) * | 2014-04-20 | 2014-06-25 | 郑家林 | External traditional Chinese medicine for treating rheumatic arthritis |
| CN104116837A (en) * | 2014-08-04 | 2014-10-29 | 熊亮 | Traditional Chinese medicine composition for treating rheumatism type diseases as well as preparation method and application thereof |
| CN108434283A (en) * | 2018-06-20 | 2018-08-24 | 李�瑞 | A kind of Chinese medicine composition for treating rheumatism bone disease |
-
2010
- 2010-11-16 CN CN2010105450054A patent/CN101983666A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103877183A (en) * | 2014-04-20 | 2014-06-25 | 郑家林 | External traditional Chinese medicine for treating rheumatic arthritis |
| CN103877183B (en) * | 2014-04-20 | 2016-02-03 | 黄荣波 | A kind of external application Chinese medicine for the treatment of rheumatic arthritis |
| CN104116837A (en) * | 2014-08-04 | 2014-10-29 | 熊亮 | Traditional Chinese medicine composition for treating rheumatism type diseases as well as preparation method and application thereof |
| CN108434283A (en) * | 2018-06-20 | 2018-08-24 | 李�瑞 | A kind of Chinese medicine composition for treating rheumatism bone disease |
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Application publication date: 20110309 |