CN105327024A - Traditional Chinese medicine preparation for treating rheumatoid arthritis - Google Patents
Traditional Chinese medicine preparation for treating rheumatoid arthritis Download PDFInfo
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- CN105327024A CN105327024A CN201510872926.4A CN201510872926A CN105327024A CN 105327024 A CN105327024 A CN 105327024A CN 201510872926 A CN201510872926 A CN 201510872926A CN 105327024 A CN105327024 A CN 105327024A
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Abstract
The invention relates to a traditional Chinese medicine preparation for treating rheumatoid arthritis. The traditional Chinese medicine preparation is prepared from Japanese coniogramme, lycopodium annotinum, curious kadsura root stems, herb of java treebine, litsea cubeba, pygmaeopremna herbacea, scandent schefflera stems and leaves, Jasminum lanceolarium Roxb., white perilla leaves, silkworm excrement, angelica morii hayara leaves, the rhizome of Chinese atractylode, cape jasmine leaves, white flower cacalia seeds, fruits of polygonum orientale, Machilus leptophylla Hand.-Mazz., Japanese cayratia herb, bunge corydalis herb, hance rosewood roots or stems, leaves of roundpod jute, a Tibetan hawksbeard root, orange seeds and acanthopanax. The traditional Chinese medicine preparation has the effects of dispelling wind and eliminating dampness, warming channels and expelling cold, promoting blood circulation to remove meridian obstruction, and reinforcing kidney to nourish qi.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation for the treatment of rheumatoid arthritis, belong to tcm field.
Background technology
Rheumatoid arthritis (rheumatoidarthritis, RA) is a kind of autoimmune disorders disease, is the chronic inflammatory reactive disorder of getting involved based on arthropathy and with multisystem.Main manifestations is synovial hyperplasia, destruction of joint, afunction etc.This sick clinical manifestation is affected joints pain, swelling, distortion, function reduction; pathological changes is in lasting, recurrent exerbation process; main pathology is changed to joint synovitis disease cellular infiltration, pannus is formed, soft Bone and bones suffers erosion; cause late period destruction of joint to occur ankylosis, deformity; movable function is badly damaged, disability.RA average prevalence about 1% worldwide, the sickness rate of China is 0.32% ~ 0.36%, is the disease that a kind of disability rate is higher, has a strong impact on the quality of life of patient.
Rheumatoid arthritis belongs to the category such as the traditional Chinese medical science " severe and migratory arthralgia ", " insensitive impediment ", " rheumatism involving the bone ", " arthroncus of knee ".Its basic pathogenesis is that the pathogens such as wind, cold, wet, heat, expectorant, the stasis of blood are detained limbs muscle arteries and veins, joint, muscle, and meridians impatency, stagnation of QI and blood may bring about pain is sent out as arthromyodynia.Patient usually body is empty, YANG QI deficiency, weakened defensive QI, and space between skin and muscles is hollow, be easily wind, cold, wet, the evil invasion and attack of taking advantage of a weak point in opponent's defence of heat, numbness resistance muscle arteries and veins, muscle, joint, and causing battalion, to defend row puckery, blockage of main and collateral channels, pain, swelling, miserable, numb occurs, or limb activity is deficient sharp.Deficient and weak YANG QI, raw in cold, feel wind-cold damp pathogen again, cold being transformed from excessive YIN, and become anemofrigid-damp arthralgia.
The toxic and side effects such as Western medicine non-steroidal drug, hormone, immunosuppressant of current western medical treatment rheumatoid arthritis is large, and patient often can not adhere to, treatment cannot be carried out smoothly.There is no specific medicament clinically at present, Chinese medicine have compared with Western medicine that source is wide, toxicity is little, treating both the principal and secondary aspects of a disease, drug effect are large, can the advantage such as long-term taking.
Summary of the invention
The invention provides a kind of Chinese medicine preparation for the treatment of rheumatoid arthritis, this Chinese medicine preparation has determined curative effect, advantage that toxic and side effects is little.It can improve the symptom of patient with rheumatoid arthritis, plays the therapeutical effect for the treatment of both the principal and secondary aspects of a disease.
Phoenix bifurcation grass energy expelling wind and removing dampness is selected, promoting blood circulation and stopping pain in side; Adhesion separation grass, expelling wind and removing dampness, promoting flow of QI and blood, both mutual reinforcements between are use, are monarch drug altogether.Select Radix seu Caulis Kadsurae Heteroclitae, promoting flow of QI and blood, Herba Cissi Javanae, detumescence dissipating blood stasis; Be equipped with that clear Fructus Solani melongenae, thousand separates grass, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Radix seu Caulis Jasmini lanceolarii can warming middle-JIAO, promoting the circulation of QI to relieve pain, expelling wind and removing dampness again.Be aided with Folium Perillae Frutescentis, Bombyx mori L., Radix angelicae morii leaf, Rhizoma Atractylodis again, Folium Gardeniae can expelling wind and cold, promoting blood circulation and detumescence.Be equipped with again Semen Caesalpiniae Minacis in side, Fructus Polygoni Orientalis, Zhu roll up micromicro blood circulation promoting and blood stasis dispelling, ipomoea cairica, Herba Corydalis Bungeanae, Caulis Dalbergiae Hancei, Folium corchori can heat-clearing and toxic substances removing, blood circulation promoting and enriching; Radix Crepidis elongatae, Semen Citri junoris, Radix Et Caulis Acanthopanacis Senticosi is equipped with in rearmost, can kidney-replenishing, replenishing QI to invigorate the spleen.All medicines share, and play Synergistic, play expelling wind and removing dampness, dispelling cold by warming the meridian, promoting blood circulation to remove obstruction in the collateral, the effect of tonifying Qi of the kidney.
Fang Zhong each side medicine source, nature and flavor, effect are as follows:
Phoenix bifurcation grass is fern Hemionitidaceae Xifeng-flavour liquor plant phoenix bifurcation Herba pteridii latiusculi ConiogrammejaponicaDiels, with root stock and all herbal medicine.Nature and flavor, bitter, micro-pungent, flat.Effect: expelling wind and removing dampness, promoting blood circulation and stopping pain, heat-clearing and toxic substances removing.
Adhesion separation grass, for the climing Lycopodium clavatum LycopodiumannotinumL. of fern Lycopodiaceae Lycopodium plant China fir is with all herbal medicine.Nature and flavor, bitter, micro-pungent, flat.Effect: expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation.
Radix seu Caulis Kadsurae Heteroclitae is root or the ratan of Magnoliacea plant Kadsuraheteroclita Kadsura heteroclita.Nature and flavor are pungent, bitter, warm in nature.Effect: expelling wind and removing dampness, promoting flow of QI and blood.
Herba Cissi Javanae is Vitaceae Herba Cissi Javanae CissusjavanaDC, with all herbal medicine.Nature and flavor, pungent, temperature.Effect: dispelling wind detoxifies, detumescence dissipating blood stasis, reunion of bone.
Clear Fructus Solani melongenae is the fruit of canella Litseacubeba (Lour.) cubeb litsen tree.Nature and flavor, pungent, micro-hardship, temperature.Effect: warming middle-JIAO to relieve pain, promoting flow of QI and blood, relievings asthma, diuresis.
Thousand separate grass, for pulse family Moghania plant Radix Flemingiae Philippinensis Moghaniaphilippinensis is used as medicine with root.Nature and flavor, sweet, tepor, flat.Effect: promoting blood circulation and stopping pain, expelling wind and removing dampness, strengthening the spleen to promote digestion.
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), for Araliaceae Schefflera plant schefflera arboricola SchefflevaarboricolaHayata and Schefflera venulosa (Wight et Arn.) Harms Svenulosa is used as medicine with stem and leaf.Nature and flavor, bitter, sweet, warm.Effect: wind-expelling pain-stopping, promoting blood circulation and detumescence.
Radix seu Caulis Jasmini lanceolarii, for Oleaceae jasmine Radix seu Caulis Jasmini lanceolarii JasminumlanceolariumRoxb. is used as medicine with stem.Nature and flavor, bitter, temperature.Effect: expelling wind and removing dampness, promoting blood circulation to remove blood stasis.
Folium Perillae Frutescentis is the leaf of labiate Perpillafrutescens common perilla.Nature and flavor, acrid in the mouth; Warm in nature.Effect: induce sweat, cold expelling, regulates the flow of vital energy, and helps digestion.
Bombyx mori L. is the dry feces of Bombycidae animal BombyxmoriL bombyx mori larva.Nature and flavor, sweet in the mouth, pungent, warm in nature.Effect: expelling wind and removing dampness, regulating the function of the stomach to resolve the turbidity, promoting blood circulation to restore menstrual flow.
Radix angelicae morii leaf is the leaf of samphire AngeliamoriiHayata Radix angelicae morii.Nature and flavor, pungent, bitter, warm in nature.Effect: expelling wind and cold, dehumidifying.
Rhizoma Atractylodis are the dry rhizome of feverfew Atractylodes lancea (Thunb.) DC. Atractylodeslancea or Atractylis chinensis AtractylodeschinensisKoidz..Nature and flavor, pungent, bitter, temperature.Effect: drying damp and strengthening spleen, expelling wind and cold, improving eyesight.
Folium Gardeniae is the leaf of dicotyledon medicine Maguireothamnus speciosus GardeniajasminoidesEllis Fructus Gardeniae.Nature and flavor, pained, cold.Effect: promoting blood circulation and detumescence, heat-clearing and toxic substances removing.
Semen Caesalpiniae Minacis is the seed of leguminous plant CaesalpiniaminaxHance south Serpentis Jin.Nature and flavor are bitter, cool cold, nontoxic.Effect: clearing away heat and eliminating dampness, eliminating stasis to stop pain.
Fructus Polygoni Orientalis is the dry mature fruit of polygonaceae plant smartweed Polygonumorientale..Nature and flavor, salty, be slightly cold.Effect: loose blood eliminating mass, removing food stagnancy pain relieving.
Zhu rolls up skin, is the bark of canella MachilusleptophyllaHand. fallen leaves hardwood nanmu.Nature and flavor, pungent, bitter, tepor.Effect: promoting blood circulation to remove blood stasis, dysentery relieving.
Ipomoea cairica is stem and leaf or the root of convolvulaceous plant Radix seu Herba Tetrastigmatis Hypoglauci.Nature and flavor, sweet, cold.Effect: heat-clearing and toxic substances removing, cough-relieving, except cold, stranguria treating and diuresis inducing.
Herba Corydalis Bungeanae is the herb of Papaveraceae Genus Corydalis Herba Corydalis Bungeanae CorydalisbungeanaTurcz..Nature and flavor are bitter, cold.Effect: heat-clearing and toxic substances removing, promoting blood circulation and detumescence.
Caulis Dalbergiae Hancei is the ratan of leguminous plant SpatholobussinensisChunetT. Spatholobus sinensis chum et T. Chen..Nature and flavor, sweet in the mouth, warm in nature.Effect: enrich blood, invigorates blood circulation.
Folium corchori is the leaf of Tiliaceae plant CorchoruscapsularisL Corchorus olitorius L..Nature and flavor are bitter, flat.
Effect: regulating QI to relieve pain; Promoting pus discharge and removing toxic substances.
Radix Crepidis elongatae is the root of feverfew CrepisrigescensDiels long shoot Radix Crepidis elongatae.Nature and flavor, bitter in the mouth, sweet, cool in nature.Effect: kidney-replenishing, replenishing QI and blood, strengthening the spleen and stomach.
Semen Citri junoris is the seed of rutaceae fragrant citrus CitrusjunosTanaka.Nature and flavor are bitter; Tepor.Effect: regulating QI to relieve pain.Main hernia; Sprain lumbago.
Radix Et Caulis Acanthopanacis Senticosi is the root of Araliaceae Acanthopanaxsenticosus Radix Et Caulis Acanthopanacis Senticosi, rhizome or stem and leaf.Nature and flavor, mildly bitter flavor, pungent, warm in nature.Effect: replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization.
Technical scheme of the present invention is: a kind of Chinese medicine preparation for the treatment of rheumatoid arthritis, it is be made up of the raw material of following weight portion: phoenix bifurcation grass 70 ~ 90 parts, adhesion separation grass 50 ~ 70 parts, Radix seu Caulis Kadsurae Heteroclitae 50 ~ 70 parts, Herba Cissi Javanae 20 ~ 40 parts, clear Fructus Solani melongenae 10 ~ 30 parts, thousand separate grass 10 ~ 30 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 30 ~ 50 parts, Radix seu Caulis Jasmini lanceolarii 20 ~ 40 parts, Folium Perillae Frutescentis 20 ~ 40 parts, Bombyx mori L. 30 ~ 50 parts, 40 ~ 60 parts, Radix angelicae morii leaf, Rhizoma Atractylodis 30 ~ 50 parts, Folium Gardeniae 20 ~ 40 parts, Semen Caesalpiniae Minacis 40 ~ 60 parts, Fructus Polygoni Orientalis 20 ~ 40 parts, Zhu rolls up skin 10 ~ 30 parts, ipomoea cairica 10 ~ 30 parts, Herba Corydalis Bungeanae 20 ~ 40 parts, Caulis Dalbergiae Hancei 20 ~ 40 parts, Folium corchori 10 ~ 30 parts, Radix Crepidis elongatae 20 ~ 40 parts, Semen Citri junoris 10 ~ 30 parts, Radix Et Caulis Acanthopanacis Senticosi 5 ~ 15 parts.
As preferably of the present invention, the Chinese medicine preparation of described treatment rheumatoid arthritis, be made up of the crude drug of following weight proportion: phoenix bifurcation grass 75 ~ 85 parts, adhesion separation grass 55 ~ 65 parts, Radix seu Caulis Kadsurae Heteroclitae 55 ~ 65 parts, Herba Cissi Javanae 25 ~ 35 parts, clear Fructus Solani melongenae 15 ~ 25 parts, thousand separate grass 15 ~ 25 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 35 ~ 45 parts, Radix seu Caulis Jasmini lanceolarii 25 ~ 35 parts, Folium Perillae Frutescentis 25 ~ 35 parts, Bombyx mori L. 35 ~ 45 parts, 45 ~ 55 parts, Radix angelicae morii leaf, Rhizoma Atractylodis 35 ~ 45 parts, Folium Gardeniae 25 ~ 35 parts, Semen Caesalpiniae Minacis 45 ~ 55 parts, Fructus Polygoni Orientalis 25 ~ 35 parts, Zhu rolls up skin 15 ~ 25 parts, ipomoea cairica 15 ~ 25 parts, Herba Corydalis Bungeanae 25 ~ 35 parts, Caulis Dalbergiae Hancei 25 ~ 35 parts, Folium corchori 15 ~ 25 parts, Radix Crepidis elongatae 25 ~ 35 parts, Semen Citri junoris 15 ~ 25 parts, Radix Et Caulis Acanthopanacis Senticosi 8 ~ 12 parts.
As present invention further optimization, the Chinese medicine preparation of described treatment rheumatoid arthritis, be made up of the crude drug of following weight proportion: phoenix bifurcation grass 80 parts, adhesion separation grass 60 parts, Radix seu Caulis Kadsurae Heteroclitae 60 parts, Herba Cissi Javanae 30 parts, clear Fructus Solani melongenae 20 parts, thousand separate grass 20 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 40 parts, Radix seu Caulis Jasmini lanceolarii 30 parts, Folium Perillae Frutescentis 30 parts, Bombyx mori L. 40 parts, 50 parts, Radix angelicae morii leaf, Rhizoma Atractylodis 40 parts, Folium Gardeniae 30 parts, Semen Caesalpiniae Minacis 50 parts, Fructus Polygoni Orientalis 30 parts, Zhu rolls up skin 20 parts, ipomoea cairica 20 parts, Herba Corydalis Bungeanae 30 parts, Caulis Dalbergiae Hancei 30 parts, Folium corchori 20 parts, Radix Crepidis elongatae 30 parts, Semen Citri junoris 20 parts, Radix Et Caulis Acanthopanacis Senticosi 10 parts.
The preparation method of the Chinese medicine preparation for the treatment of rheumatoid arthritis of the present invention, is made up of following steps:
(1) get Radix seu Caulis Kadsurae Heteroclitae, Caulis Dalbergiae Hancei, Radix Et Caulis Acanthopanacis Senticosi medical material, add medical material weight ratio 8 times amount 50% ~ 70% ethanol, reflux, extract, 2 times, each 1.5h, filters, and merging filtrate also reclaims ethanol extremely without after alcohol taste, concentration of liquid medicine drying is also ground into dried cream powder, and sieve, medicinal residues are for subsequent use;
(2) by careless with phoenix bifurcation again for step medicinal residues (1), adhesion separation grass, Herba Cissi Javanae, clear Fructus Solani melongenae, thousand separate grass, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Radix seu Caulis Jasmini lanceolarii, Folium Perillae Frutescentis, Bombyx mori L., Radix angelicae morii leaf, Rhizoma Atractylodis, Folium Gardeniae, Semen Caesalpiniae Minacis, Fructus Polygoni Orientalis, Zhu rolls up skin, ipomoea cairica, Herba Corydalis Bungeanae, Folium corchori, Radix Crepidis elongatae, Semen Citri junoris medical material merges, add the soak by water 2 times of medical material weight ratio 7 ~ 10 times amount, each 1h, filter, merging filtrate, concentrating under reduced pressure becomes relative density to be 1.10 clear paste, adding ethanol makes alcohol content reach 50% ~ 70%, leave standstill 6 ~ 18h, filter, decompression filtrate recycling ethanol, concentrating under reduced pressure drying is also ground into dried cream powder, sieve, for subsequent use,
(3) by above-mentioned steps (1) and (2) dried cream powder, after mix homogeneously, then oral formulations made by the adjuvant adding pharmaceutics conventional.
As preferred further, the preparation method of the Chinese medicine preparation for the treatment of rheumatoid arthritis of the present invention, is made up of following steps:
(1) get Radix seu Caulis Kadsurae Heteroclitae, Caulis Dalbergiae Hancei, Radix Et Caulis Acanthopanacis Senticosi medical material, add medical material weight ratio 8 times amount 60% ethanol, reflux, extract, 2 times, each 1.5h, filter, merging filtrate also reclaims ethanol extremely without after alcohol taste, and concentration of liquid medicine is dry is also ground into dried cream powder, and sieve, medicinal residues are for subsequent use;
(2) by careless with phoenix bifurcation again for step medicinal residues (1), adhesion separation grass, Herba Cissi Javanae, clear Fructus Solani melongenae, thousand separate grass, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Radix seu Caulis Jasmini lanceolarii, Folium Perillae Frutescentis, Bombyx mori L., Radix angelicae morii leaf, Rhizoma Atractylodis, Folium Gardeniae, Semen Caesalpiniae Minacis, Fructus Polygoni Orientalis, Zhu rolls up skin, ipomoea cairica, Herba Corydalis Bungeanae, Folium corchori, Radix Crepidis elongatae, Semen Citri junoris medical material merges, add the soak by water 2 times of medical material weight ratio 9 times amount, each 1h, filter, merging filtrate, concentrating under reduced pressure becomes relative density to be 1.10 clear paste, adding ethanol makes alcohol content reach 60%, leave standstill 12h, filter, decompression filtrate recycling ethanol, concentrating under reduced pressure drying is also ground into dried cream powder, sieve, for subsequent use,
(3) by above-mentioned steps (1) and (2) dried cream powder, after mix homogeneously, then oral formulations made by the adjuvant adding pharmaceutics conventional.
The oral formulations that technical solution of the present invention is made can be granule, hard capsule, tablet or drop pill.The beneficial effect of Chinese medicine preparation of the present invention:
Each crude drug component in Chinese medicine preparation of the present invention and proportioning thereof, grope out through differential diagnosis in tcm compatibility and clinical empirical summary.Its each medical material is theoretical according to Chinese medicine monarch, and compatibility complements each other using, and has Synergistic and Attenuation, makes entirely just to have expelling wind and removing dampness, dispelling cold by warming the meridian, promoting blood circulation to remove obstruction in the collateral, the effect of tonifying Qi of the kidney.Chinese medicine preparation of the present invention can enhancing human body immunity function, by improving microcirculation disturbance, suppressing fibrocyte proliferation, alleviating red and swollen heat pain symptom in patient disease inflammatory process.
Chinese medicine preparation of the present invention has evident in efficacy, the advantage that toxic and side effects is little.Through clinical verification, the effective percentage of the clinical cure of Chinese medicine preparation of the present invention is up to 95.5%, and all cases all have no adverse reaction.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is done to describing further, but protection scope of the present invention be not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment 1
(1) get Radix seu Caulis Kadsurae Heteroclitae 60g, Caulis Dalbergiae Hancei 30g, Radix Et Caulis Acanthopanacis Senticosi 10g, add medical material weight ratio 8 times amount 60% ethanol, reflux, extract, 2 times, each 1.5h, filters, and merging filtrate also reclaims ethanol extremely without after alcohol taste, concentration of liquid medicine drying is also ground into dried cream powder, and sieve, medicinal residues are for subsequent use;
(2) by the step medicinal residues careless 80g with phoenix bifurcation more (1), adhesion separation grass 60g, Herba Cissi Javanae 30g, clear Fructus Solani melongenae 20g, thousand separate careless 20g, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 40g, Radix seu Caulis Jasmini lanceolarii 30g, Folium Perillae Frutescentis 30g, Bombyx mori L. 40g, Radix angelicae morii leaf 50g, Rhizoma Atractylodis 40g, Folium Gardeniae 30g, Semen Caesalpiniae Minacis 50g, Fructus Polygoni Orientalis 30g, Zhu rolls up skin 20g, ipomoea cairica 20g, Herba Corydalis Bungeanae 30g, Folium corchori 20g, Radix Crepidis elongatae 30g, Semen Citri junoris 20g merges, add the soak by water 2 times of medical material weight ratio 9 times amount, each 1h, filter, merging filtrate, concentrating under reduced pressure becomes relative density to be 1.10 clear paste, adding ethanol makes alcohol content reach 60%, leave standstill 12h, filter, decompression filtrate recycling ethanol, concentrating under reduced pressure drying is also ground into dried cream powder, sieve, for subsequent use,
(3) by above-mentioned steps (1) and (2) dried cream powder, after mix homogeneously, add appropriate starch, calcium hydrogen phosphate, granulate, encapsulated, make 1000 hard capsules.
Embodiment 2
(1) get Radix seu Caulis Kadsurae Heteroclitae 70g, Caulis Dalbergiae Hancei 20g, Radix Et Caulis Acanthopanacis Senticosi 5g, add medical material weight ratio 8 times amount 50% ethanol, reflux, extract, 2 times, each 1.5h, filters, and merging filtrate also reclaims ethanol extremely without after alcohol taste, concentration of liquid medicine drying is also ground into dried cream powder, and sieve, medicinal residues are for subsequent use;
(2) by the step medicinal residues careless 70g with phoenix bifurcation more (1), adhesion separation grass 50g, Herba Cissi Javanae 20g, clear Fructus Solani melongenae 30g, thousand separate careless 30g, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 30g, Radix seu Caulis Jasmini lanceolarii 20g, Folium Perillae Frutescentis 40g, Bombyx mori L. 50g, Radix angelicae morii leaf 40g, Rhizoma Atractylodis 50g, Folium Gardeniae 40g, Semen Caesalpiniae Minacis 60g, Fructus Polygoni Orientalis 20g, Zhu rolls up skin 10g, ipomoea cairica 30g, Herba Corydalis Bungeanae 40g, Folium corchori 10g, Radix Crepidis elongatae 40g, Semen Citri junoris 30g, add the soak by water 2 times of medical material weight ratio 10 times amount, each 1h, filter, merging filtrate, concentrating under reduced pressure becomes relative density to be 1.10 clear paste, adding ethanol makes alcohol content reach 70%, leave standstill 18h, filter, decompression filtrate recycling ethanol, concentrating under reduced pressure drying is also ground into dried cream powder, sieve, for subsequent use,
(3) by above-mentioned steps (1) and (2) dried cream powder, after mix homogeneously, add appropriate dextrin, sucrose, lactose, mixing, granulate, dry, make 1000g granule.
Embodiment 3
(1) get Radix seu Caulis Kadsurae Heteroclitae 50g, Caulis Dalbergiae Hancei 40g, Radix Et Caulis Acanthopanacis Senticosi 15g, add medical material weight ratio 8 times amount 70% ethanol, reflux, extract, 2 times, each 1.5h, filters, and merging filtrate also reclaims ethanol extremely without after alcohol taste, concentration of liquid medicine drying is also ground into dried cream powder, and sieve, medicinal residues are for subsequent use;
(2) by the step medicinal residues careless 90g with phoenix bifurcation more (1), adhesion separation grass 70g, Herba Cissi Javanae 40g, clear Fructus Solani melongenae 10g, thousand separate careless 10g, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 50g, Radix seu Caulis Jasmini lanceolarii 40g, Folium Perillae Frutescentis 20g, Bombyx mori L. 30g, Radix angelicae morii leaf 60g, Rhizoma Atractylodis 30g, Folium Gardeniae 20g, Semen Caesalpiniae Minacis 40g, Fructus Polygoni Orientalis 40g, Zhu rolls up skin 30g, ipomoea cairica 10g, Herba Corydalis Bungeanae 20g, Folium corchori 30g, Radix Crepidis elongatae 20g, Semen Citri junoris 10g, add the soak by water 2 times of medical material weight ratio 7 times amount, each 1h, filter, merging filtrate, concentrating under reduced pressure becomes relative density to be 1.10 clear paste, adding ethanol makes alcohol content reach 50%, leave standstill 6h, filter, decompression filtrate recycling ethanol, concentrating under reduced pressure drying is also ground into dried cream powder, sieve, for subsequent use,
(3) by above-mentioned steps (1) and (2) dried cream powder, after mix homogeneously, add appropriate carboxymethyl starch sodium, magnesium stearate, mixing, granulate, be pressed into 1000 tablets.
Embodiment 4
(1) get Radix seu Caulis Kadsurae Heteroclitae 55g, Caulis Dalbergiae Hancei 25g, Radix Et Caulis Acanthopanacis Senticosi 12g, add medical material weight ratio 8 times amount 60% ethanol, reflux, extract, 2 times, each 1.5h, filters, and merging filtrate also reclaims ethanol extremely without after alcohol taste, concentration of liquid medicine drying is also ground into dried cream powder, and sieve, medicinal residues are for subsequent use;
(2) by the step medicinal residues careless 85g with phoenix bifurcation more (1), adhesion separation grass 55g, Herba Cissi Javanae 35g, clear Fructus Solani melongenae 15g, thousand separate careless 25g, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 45g, Radix seu Caulis Jasmini lanceolarii 35g, Folium Perillae Frutescentis 25g, Bombyx mori L. 35g, Radix angelicae morii leaf 55g, Rhizoma Atractylodis 35g, Folium Gardeniae 25g, Semen Caesalpiniae Minacis 45g, Fructus Polygoni Orientalis 25g, Zhu rolls up skin 25g, ipomoea cairica 25g, Herba Corydalis Bungeanae 35g, Folium corchori 15g, Radix Crepidis elongatae 25g, Semen Citri junoris 25g, add the soak by water 2 times of medical material weight ratio 8 times amount, each 1h, filter, merging filtrate, concentrating under reduced pressure becomes relative density to be 1.10 clear paste, adding ethanol makes alcohol content reach 70%, leave standstill 12h, filter, decompression filtrate recycling ethanol, concentrating under reduced pressure drying is also ground into dried cream powder, sieve, for subsequent use,
(3), by above-mentioned steps (1) and (2) dried cream powder, after mix homogeneously, then add PEG4000, PEG6000 as substrate, heated and stirred evenly after, carry out dripping, make 1000 drop pills.
Embodiment 5
(1) get Radix seu Caulis Kadsurae Heteroclitae 65g, Caulis Dalbergiae Hancei 35g, Radix Et Caulis Acanthopanacis Senticosi 8g, add medical material weight ratio 8 times amount 70% ethanol, reflux, extract, 2 times, each 1.5h, filters, and merging filtrate also reclaims ethanol extremely without after alcohol taste, concentration of liquid medicine drying is also ground into dried cream powder, and sieve, medicinal residues are for subsequent use;
(2) by the step medicinal residues careless 75g with phoenix bifurcation more (1), adhesion separation grass 65g, Herba Cissi Javanae 25g, clear Fructus Solani melongenae 25g, thousand separate careless 15g, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 35g, Radix seu Caulis Jasmini lanceolarii 25g, Folium Perillae Frutescentis 35g, Bombyx mori L. 45g, Radix angelicae morii leaf 45g, Rhizoma Atractylodis 45g, Folium Gardeniae 35g, Semen Caesalpiniae Minacis 55g, Fructus Polygoni Orientalis 35g, Zhu rolls up skin 15g, ipomoea cairica 15g, Herba Corydalis Bungeanae 25g, Folium corchori 25g, Radix Crepidis elongatae 35g, Semen Citri junoris 15g, add the soak by water 2 times of medical material weight ratio 9 times amount, each 1h, filter, merging filtrate, concentrating under reduced pressure becomes relative density to be 1.10 clear paste, adding ethanol makes alcohol content reach 60%, leave standstill 10h, filter, decompression filtrate recycling ethanol, concentrating under reduced pressure drying is also ground into dried cream powder, sieve, for subsequent use,
(3), by above-mentioned steps (1) and (2) dried cream powder, after mix homogeneously, add hydroxypropyl emthylcellulose, then with 65% ethanol for binding agent, pill, after carrying out drying, becomes 1000 balls.
In order to verify the curative effect of Chinese medicine preparation of the present invention further, we, by the Chinese medicine capsules of preparation in above-mentioned specific embodiment 1, have carried out corresponding clinical trial, existing that report the test is as follows.
Chinese medicine preparation of the present invention is to the clinical observation of rheumatoid arthritis
1.1 physical data
Accept rheumatoid arthritis example patient totally 129 examples for medical treatment, be divided into treatment group and matched group at random.Treatment group 66 example, man 27 example, female 39 example, 27 ~ 65 years old age, average 46.3 years old, the course of disease August ~ 7 years, average 3.2 years; Matched group 63 example, man 21 example, female 42 example, 27 ~ 63 years old age, average 47.2 years old.Course of disease October ~ 8 year, average 3.6 years; 2 groups of patient's physical data compare, and learn meaning (P > 0.05) without significance difference.
1.2 diagnostic criteria
All patients all meet the diagnosis of rheumatoid arthritis standard that " new Chinese medicine guideline of clinical investigations " is worked out, and make a definite diagnosis with reference to the rheumatoid arthritis standard of American Rheumatism Association (ARA) revision in 1987.Tcm diagnosis standard: Chinese medical discrimination meets Ministry of Health of the People's Republic of China's issuing standard.
1.3 Therapeutic Method
Matched group: Tengluoning capsules (Tonghua, Jilin Province Bo Xiang Pharmaceutical limited company), oral, one time 5,3 times on the one.Within 2 weeks, be a course for the treatment of, serve on 3 courses for the treatment of, evaluate its curative effect.
Treatment group: according to the preparation method of the embodiment of the present invention 1 group, obtained Chinese medicine capsules, oral, 5 dosage units, 3 times on the one, it is identical with matched group to take the course for the treatment of.
Observation index clinical symptoms and sign: the equal itemized record medical history of all patients, symptom, sign and auxiliary examination result.Comprise stiff time in morning, periphery arthralgia and swelling index, tenderness index, immunoglobulin, ESR (erythrocyte sedimentation rate), CRP (c reactive protein), untoward reaction etc.
1.4 efficacy assessment standard
1.4.1 criterion of therapeutical effect
Be divided into according to State Administration of Traditional Chinese Medicine's " disease of tcm Standardization of diagnosis and curative effect ": clinical remission, effective, effective, invalid level Four.Clinical remission: symptom, sign all disappear, and experimental index is normal; Effective: symptom, sign major part disappears or alleviates, and experimental index is normal; Effective: symptom, body are demonstrate,proved to have and alleviated, and experimental index is improved; Invalid: symptom, sign is all not improved, and experimental index is unchanged.
1.5 therapeutic outcome
Table 1 liang group overall patient efficacy evaluation result
Note, compared with matched group,
△p<0.05.
Shown by table 1 result, Chinese medicine preparation of the present invention is remarkable at treatment rheumatoid arthritis clinical efficacy, is obviously better than matched group (P<0.05).
Clinical symptoms, sign Index change before and after table 2 liang group patient treatment
Note, compared with matched group,
△p<0.05,
△ △p<0.01, compares with before treatment, * * P<0.01, * P<0.05.
Experimental result shows, after 3 course for the treatment of Drug therapys, the stiff time in morning for the treatment of group and matched group patient, each tract pain, swelling symptom improve significantly (P<0.05), and the therapeutic effect of Chinese medicine preparation of the present invention is better than matched group.
Before and after table 3 liang group patient treatment, immunological indices compares with erythrocyte sedimentation rate
Note, compared with matched group,
△p<0.05,
△ △p<0.01, compares with before treatment, * * P<0.01, * P<0.05.
Result shows, 2 groups of patients body fluid index before the treatment at immunoglobulin, CRP, erythrocyte sedimentation rate all apparently higher than normal value.After the treatment of medicine, every immune indexes of matched group and treatment group patient all makes moderate progress, and is obviously better than matched group (P<0.05 or P<0.01).
Untoward reaction is in clinical observation, and matched group occurs slight epigastric discomfort after finding 2 routine patient consumes, defecates rare, continues patient's spontaneous recovery in 2 days; Treatment group has no obvious toxicity.2 groups are showed no the exception of hepatic and renal function and blood, urine, feces routine after terminating the course for the treatment of.
In sum, Chinese medicine preparation of the present invention in preparation treatment rheumatoid arthritis disease determined curative effect, significantly, the little advantage of untoward reaction, clinic is applied.
Claims (6)
1. treat the Chinese medicine preparation of rheumatoid arthritis for one kind, it is characterized in that, it is mainly made up of the crude drug of following weight proportion: phoenix bifurcation grass 70 ~ 90 parts, adhesion separation grass 50 ~ 70 parts, Radix seu Caulis Kadsurae Heteroclitae 50 ~ 70 parts, Herba Cissi Javanae 20 ~ 40 parts, clear Fructus Solani melongenae 10 ~ 30 parts, thousand separate grass 10 ~ 30 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 30 ~ 50 parts, Radix seu Caulis Jasmini lanceolarii 20 ~ 40 parts, Folium Perillae Frutescentis 20 ~ 40 parts, Bombyx mori L. 30 ~ 50 parts, 40 ~ 60 parts, Radix angelicae morii leaf, Rhizoma Atractylodis 30 ~ 50 parts, Folium Gardeniae 20 ~ 40 parts, Semen Caesalpiniae Minacis 40 ~ 60 parts, Fructus Polygoni Orientalis 20 ~ 40 parts, Zhu rolls up skin 10 ~ 30 parts, ipomoea cairica 10 ~ 30 parts, Herba Corydalis Bungeanae 20 ~ 40 parts, Caulis Dalbergiae Hancei 20 ~ 40 parts, Folium corchori 10 ~ 30 parts, Radix Crepidis elongatae 20 ~ 40 parts, Semen Citri junoris 10 ~ 30 parts, Radix Et Caulis Acanthopanacis Senticosi 5 ~ 15 parts.
2. the Chinese medicine preparation for the treatment of rheumatoid arthritis as claimed in claim 1, it is characterized in that, it is mainly made up of the crude drug of following weight proportion: phoenix bifurcation grass 75 ~ 85 parts, adhesion separation grass 55 ~ 65 parts, Radix seu Caulis Kadsurae Heteroclitae 55 ~ 65 parts, Herba Cissi Javanae 25 ~ 35 parts, clear Fructus Solani melongenae 15 ~ 25 parts, thousand separate grass 15 ~ 25 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 35 ~ 45 parts, Radix seu Caulis Jasmini lanceolarii 25 ~ 35 parts, Folium Perillae Frutescentis 25 ~ 35 parts, Bombyx mori L. 35 ~ 45 parts, 45 ~ 55 parts, Radix angelicae morii leaf, Rhizoma Atractylodis 35 ~ 45 parts, Folium Gardeniae 25 ~ 35 parts, Semen Caesalpiniae Minacis 45 ~ 55 parts, Fructus Polygoni Orientalis 25 ~ 35 parts, Zhu rolls up skin 15 ~ 25 parts, ipomoea cairica 15 ~ 25 parts, Herba Corydalis Bungeanae 25 ~ 35 parts, Caulis Dalbergiae Hancei 25 ~ 35 parts, Folium corchori 15 ~ 25 parts, Radix Crepidis elongatae 25 ~ 35 parts, Semen Citri junoris 15 ~ 25 parts, Radix Et Caulis Acanthopanacis Senticosi 8 ~ 12 parts.
3. the Chinese medicine preparation for the treatment of rheumatoid arthritis as claimed in claim 1, it is characterized in that, it is mainly made up of the crude drug of following weight proportion: phoenix bifurcation grass 80 parts, adhesion separation grass 60 parts, Radix seu Caulis Kadsurae Heteroclitae 60 parts, Herba Cissi Javanae 30 parts, clear Fructus Solani melongenae 20 parts, thousand separate grass 20 parts, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 40 parts, Radix seu Caulis Jasmini lanceolarii 30 parts, Folium Perillae Frutescentis 30 parts, Bombyx mori L. 40 parts, 50 parts, Radix angelicae morii leaf, Rhizoma Atractylodis 40 parts, Folium Gardeniae 30 parts, Semen Caesalpiniae Minacis 50 parts, Fructus Polygoni Orientalis 30 parts, Zhu rolls up skin 20 parts, ipomoea cairica 20 parts, Herba Corydalis Bungeanae 30 parts, Caulis Dalbergiae Hancei 30 parts, Folium corchori 20 parts, Radix Crepidis elongatae 30 parts, Semen Citri junoris 20 parts, Radix Et Caulis Acanthopanacis Senticosi 10 parts.
4. the preparation method of the Chinese medicine preparation for the treatment of rheumatoid arthritis as described in as arbitrary in claims 1 to 3, it is characterized in that, described preparation method is made up of following steps:
(1) get Radix seu Caulis Kadsurae Heteroclitae, Caulis Dalbergiae Hancei, Radix Et Caulis Acanthopanacis Senticosi medical material, add medical material weight ratio 8 times amount 50% ~ 70% ethanol, reflux, extract, 2 times, each 1.5h, filters, and merging filtrate also reclaims ethanol extremely without after alcohol taste, concentration of liquid medicine drying is also ground into dried cream powder, and sieve, medicinal residues are for subsequent use;
(2) by careless with phoenix bifurcation again for step medicinal residues (1), adhesion separation grass, Herba Cissi Javanae, clear Fructus Solani melongenae, thousand separate grass, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Radix seu Caulis Jasmini lanceolarii, Folium Perillae Frutescentis, Bombyx mori L., Radix angelicae morii leaf, Rhizoma Atractylodis, Folium Gardeniae, Semen Caesalpiniae Minacis, Fructus Polygoni Orientalis, Zhu rolls up skin, ipomoea cairica, Herba Corydalis Bungeanae, Folium corchori, Radix Crepidis elongatae, Semen Citri junoris medical material merges, add the soak by water 2 times of medical material weight ratio 7 ~ 10 times amount, each 1h, filter, merging filtrate, concentrating under reduced pressure becomes relative density to be 1.10 clear paste, adding ethanol makes alcohol content reach 50% ~ 70%, leave standstill 6 ~ 18h, filter, decompression filtrate recycling ethanol, concentrating under reduced pressure drying is also ground into dried cream powder, sieve, for subsequent use,
(3) by above-mentioned steps (1) and (2) dried cream powder, after mix homogeneously, then oral formulations made by the adjuvant adding pharmaceutics conventional.
5. treat the preparation method of the Chinese medicine preparation of rheumatoid arthritis as claimed in claim 4, it is characterized in that, described preparation method is made up of following steps:
(1) get Radix seu Caulis Kadsurae Heteroclitae, Caulis Dalbergiae Hancei, Radix Et Caulis Acanthopanacis Senticosi medical material, add medical material weight ratio 8 times amount 60% ethanol, reflux, extract, 2 times, each 1.5h, filter, merging filtrate also reclaims ethanol extremely without after alcohol taste, and concentration of liquid medicine is dry is also ground into dried cream powder, and sieve, medicinal residues are for subsequent use;
(2) by careless with phoenix bifurcation again for step medicinal residues (1), adhesion separation grass, Herba Cissi Javanae, clear Fructus Solani melongenae, thousand separate grass, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Radix seu Caulis Jasmini lanceolarii, Folium Perillae Frutescentis, Bombyx mori L., Radix angelicae morii leaf, Rhizoma Atractylodis, Folium Gardeniae, Semen Caesalpiniae Minacis, Fructus Polygoni Orientalis, Zhu rolls up skin, ipomoea cairica, Herba Corydalis Bungeanae, Folium corchori, Radix Crepidis elongatae, Semen Citri junoris medical material merges, add the soak by water 2 times of medical material weight ratio 9 times amount, each 1h, filter, merging filtrate, concentrating under reduced pressure becomes relative density to be 1.10 clear paste, adding ethanol makes alcohol content reach 60%, leave standstill 12h, filter, decompression filtrate recycling ethanol, concentrating under reduced pressure drying is also ground into dried cream powder, sieve, for subsequent use,
(3) by above-mentioned steps (1) and (2) dried cream powder, after mix homogeneously, then oral formulations made by the adjuvant adding pharmaceutics conventional.
6. treat the Chinese medicine preparation of rheumatoid arthritis as claimed in claim 5, it is characterized in that, the dosage form of described Chinese medicine preparation is granule, capsule, tablet, drop pill, pill etc.
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| 朱少荣等: "痹通合剂治疗类风湿性关节炎68例临床观察", 《甘肃中医》 * |
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