CN106038912A - Traditional Chinese medicine preparation for treating rheumatoid arthritis - Google Patents

Traditional Chinese medicine preparation for treating rheumatoid arthritis Download PDF

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CN106038912A
CN106038912A CN201610472023.1A CN201610472023A CN106038912A CN 106038912 A CN106038912 A CN 106038912A CN 201610472023 A CN201610472023 A CN 201610472023A CN 106038912 A CN106038912 A CN 106038912A
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herba
radix
chinese medicine
medicine preparation
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唐家婷
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Abstract

The invention relates to a traditional Chinese medicine preparation for treating rheumatoid arthritis. The traditional Chinese medicine preparation is prepared from the following raw medicines in parts by weight: 110-130 parts of glabrous sarcandra herb, 110-130 parts of madder, 90-110 parts of homalomena rhizoma, 90-110 parts of croton crassifolius, 50-70 parts of lysimachia foenum-graecum, 40-60 parts of hypericum sampsonii hance, 50-70 parts of erythrina bark, 40-60 parts of berba aristolochiae mollissimae, 70-90 parts of yam rhizome, 50-70 parts of euonymus fortunei, 30-50 parts of tinospora sinensis merr, 20-40 parts of origanum, 50-70 parts of thin evodia, 40-60 parts of cayratia japonica, 30-50 parts of berchemia lineata, 40-60 parts of clerodendron bungei, 50-70 parts of cudweed, 30-50 parts of scape-like sage herb, 30-50 parts of erodium stephanianum willd, 20-40 parts of acanthopanax leucorrhizus, 30-50 parts of peucedanum morisonii, 30-50 parts of piper puberulum maxim and 10-30 parts of finelydivided phtheirospermum roots. The traditional Chinese medicine preparation has the effects of dispelling wind and eliminating dampness, promoting blood circulation and dredging collaterals, promoting qi circulation to relieve pain as well as strengthening the muscles and bones.

Description

A kind of Chinese medicine preparation treating rheumatoid arthritis
Technical field
The present invention relates to a kind of Chinese medicine preparation treating rheumatoid arthritis, belong to the field of Chinese medicines.
Background technology
Rheumatoid arthritis (rheumatoid arthritis, RA) be a kind of be main performance with joint chronic inflammatory disease Autoimmune disease.This disease disability rate is higher, and such as rational therapy the most early, 3 years intrinsic articulations destroy and reach 70%.The clinic of this disease With stiff, swell and ache, joint deformity, muscle Chu contract, can not bend and stretch, sclerotin is impaired etc. is characterized.Western medicine conventional in the market, Though symptom can be improved, reduce inflammation, but finally all fail to be effectively prevented bone erosion, block course advancement, and prolonged application is secondary Effect is big.Up to the present, western modern medicine treatment primary disease there is no effective method.
Primary disease belongs to Chinese medicine " arthromyodynia ", " severe and migratory arthralgia ", " arthroncus of knee ", " numbness " category.The traditional Chinese medical science think primary disease many by (wind, Cold, wet, hot etc.) pathogen takes advantage of it (liver spleen kidney qi blood) all void of human body, visitor to alter body, fights mutually with QI and blood, deeply invades kidney, and cause venation and coagulate Resistance, disharmony of nutrient QI with defensive QI, meridians accumulation of heat, coldheat complex, ultimately result in the pathologic products such as cold-damp, pyretic toxicity, turbid, the blood stasis of expectorant and mutually hand over Knot, illegally occupies muscle arteries and veins skeleton, delays and do not go to form.Its etiology and pathogenesis mainly has heresy, the stasis of blood, empty three broad aspect.Diseased region mainly relates to And liver spleen kidney three is dirty.Pathologic feature deficiency in origin and excess in superficiality, coldheat complex.Therefore dispel wind, cold, wet, heat, expectorant, the stasis of blood, invigorating liver and spleen kidney qi blood For treating the main rule of this disease.Chinese medicine primary disease is typically based on determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, by multi-level, too many levels, many ways Footpath, multiple target effect, in human body, anti-inflammatory and antalgic, regulate immunologic function, stop pathological development, have greater advantage.
Summary of the invention
In order to solve the problems referred to above, the present invention provides a kind of Chinese medicine preparation treating rheumatoid arthritis.The application's Inventor through clinical experience for many years, research summary repeatedly, and finally have found Chinese medicine system evident in efficacy, that have no side effect Agent.
With Herba Sarcandrae, Radix Rubiae promoting blood circulation to remove obstruction in the collateral in side, it is aided with Rhizoma Homalomenae, Radix Crotonis Crassifolii, Herba Lysimachiae foenum-graeci, Herba Hyperici Sampsonii four medicine match With, strong bone can be played and invigorate blood circulation, the effect of promoting the circulation of QI to relieve pain；It is equipped with Cortex erythrinae, Herba Aristolochiae Mollissimae, Bi, Caulis Seu Folium Euonymi Fortunei, Herba Lycopodii, Adeps Bovis seu Bubali, trident Hardship, Herba Cayatiae Japonicae, Radix berchemiae lineatae, Caulis et folium clerodendri bungei, Herba Gnaphalii Affinis can expelling wind and removing dampness, blood-activating analgetic, add Herba Salviae Scapiformis, geranium, acanthopanax leucorrhizus Harms Three medicines can the side's of enhancing medicine, strong muscles and bones, the meridian dredging, effect of wind-damp dispelling；It is eventually adding cold syndrome of the stomach grass, Herba Piper Spuberuli, Phtheirospermum tenuisectum Bur.et Franch., row can be made Gas pain relieving, the merit of nourishing blood to tranquillize the mind；All medicines share so that produce the effect of Synergistic between each medicine, make full side play altogether and dispel Wind dehumidifying, promoting blood circulation to remove obstruction in the collateral, promoting the circulation of QI to relieve pain, the merit of strong muscles and bones.
The present invention treats the Chinese medicine preparation of rheumatoid arthritis, and it is made up of the crude drug of following weight proportion: swollen Joint wind 110～130 parts, Radix Rubiae 110～130 parts, Rhizoma Homalomenae 90～110 parts, Radix Crotonis Crassifolii 90～110 parts, Herba Lysimachiae foenum-graeci 50～70 parts, Herba Hyperici Sampsonii 40～60 parts, Cortex erythrinae 50～70 parts, Herba Aristolochiae Mollissimae 40～60 parts, Bi 70～90 parts, Caulis Seu Folium Euonymi Fortunei 50～70 parts, wide muscle Rattan 30～50 parts, Adeps Bovis seu Bubali 20～40 parts, Foliumet Ramulus Evodiae 50～70 parts, Herba Cayatiae Japonicae 40～60 parts, Radix berchemiae lineatae 30～50 parts, Caulis et folium clerodendri bungei 40 ～60 parts, Herba Gnaphalii Affinis 50～70 parts, Herba Salviae Scapiformis 30～50 parts, geranium 30～50 parts, acanthopanax leucorrhizus Harms 20～40 parts, cold syndrome of the stomach grass 30～ 50 parts, Herba Piper Spuberuli 30～50 parts, Phtheirospermum tenuisectum Bur.et Franch. 10～30 parts.
Preferably, the present invention treats the Chinese medicine preparation of rheumatoid arthritis, and it is by the crude drug of following weight proportion Make: Herba Sarcandrae 120 parts, 120 parts of Radix Rubiae, Rhizoma Homalomenae 100 parts, Radix Crotonis Crassifolii 100 parts, Herba Lysimachiae foenum-graeci 60 parts, Herba Hyperici Sampsonii 50 parts, pittosporum tobira Skin 60 parts, Herba Aristolochiae Mollissimae 50 parts, Bi 80 parts, Caulis Seu Folium Euonymi Fortunei 80 parts, Herba Lycopodii 40 parts, Adeps Bovis seu Bubali 30 parts, Foliumet Ramulus Evodiae 60 parts, Herba Cayatiae Japonicae 60 Part, Radix berchemiae lineatae 40 parts, Caulis et folium clerodendri bungei 60 parts, Herba Gnaphalii Affinis 60 parts, Herba Salviae Scapiformis 40 parts, geranium 40 parts, acanthopanax leucorrhizus Harms 30 parts, cold syndrome of the stomach grass 40 Part, Herba Piper Spuberuli 40 parts, Phtheirospermum tenuisectum Bur.et Franch. 20 parts.
Preferably, the present invention treats the Chinese medicine preparation of rheumatoid arthritis, and it is by the crude drug of following weight proportion Make: Herba Sarcandrae 130 parts, 130 parts of Radix Rubiae, Rhizoma Homalomenae 90 parts, Radix Crotonis Crassifolii 110 parts, Herba Lysimachiae foenum-graeci 50 parts, Herba Hyperici Sampsonii 60 parts, pittosporum tobira Skin 50 parts, Herba Aristolochiae Mollissimae 40 parts, Bi 90 parts, Caulis Seu Folium Euonymi Fortunei 50 parts, Herba Lycopodii 30 parts, Adeps Bovis seu Bubali 20 parts, Foliumet Ramulus Evodiae 70 parts, Herba Cayatiae Japonicae 60 Part, Radix berchemiae lineatae 50 parts, Caulis et folium clerodendri bungei 40 parts, Herba Gnaphalii Affinis 50 parts, Herba Salviae Scapiformis 30 parts, geranium 50 parts, acanthopanax leucorrhizus Harms 40 parts, cold syndrome of the stomach grass 30 Part, Herba Piper Spuberuli 30 parts, Phtheirospermum tenuisectum Bur.et Franch. 10 parts.
Preferably, the present invention treats the Chinese medicine preparation of rheumatoid arthritis, and it is by the crude drug of following weight proportion Make: Herba Sarcandrae 110 parts, 110 parts of Radix Rubiae, Rhizoma Homalomenae 110 parts, Radix Crotonis Crassifolii 90 parts, Herba Lysimachiae foenum-graeci 70 parts, Herba Hyperici Sampsonii 40 parts, pittosporum tobira Skin 70 parts, Herba Aristolochiae Mollissimae 60 parts, Bi 70 parts, Caulis Seu Folium Euonymi Fortunei 70 parts, Herba Lycopodii 50 parts, Adeps Bovis seu Bubali 40 parts, Foliumet Ramulus Evodiae 50 parts, Herba Cayatiae Japonicae 40 Part, Radix berchemiae lineatae 30 parts, Caulis et folium clerodendri bungei 60 parts, Herba Gnaphalii Affinis 70 parts, Herba Salviae Scapiformis 50 parts, geranium 30 parts, acanthopanax leucorrhizus Harms 20 parts, cold syndrome of the stomach grass 50 Part, Herba Piper Spuberuli 50 parts, Phtheirospermum tenuisectum Bur.et Franch. 30 parts.
The active Chinese drug component component of the present invention can add various adjuvants conventional on pharmaceutics, such as disintegrating agent, lubricant, glues Mixture etc. are prepared as oral formulations, such as tablet, dispersible tablet, capsule, drop pill, granule with conventional method of Chinese medicinal.
The present invention treats the preparation method of the Chinese medicine preparation of rheumatoid arthritis, and it is to be prepared from by following steps:
(1) Radix Crotonis Crassifolii, Cortex erythrinae, Caulis Seu Folium Euonymi Fortunei are ground into fine powder, standby；
(2) take Radix Rubiae, geranium, with 50%～70% ethanol infiltration, be 7～9 times amount 50%～70% by medical material weight ratio Ethanol carries out percolation, collects percolate, decompression recycling ethanol, concentrates, dried, and is ground into dried cream powder, sieves, and medicinal residues are standby With；
By the medicinal residues of (2) again with Herba Sarcandrae, Rhizoma Homalomenae, Herba Lysimachiae foenum-graeci, Herba Hyperici Sampsonii, Herba Aristolochiae Mollissimae, Bi, Herba Lycopodii, Adeps Bovis seu Bubali, Foliumet Ramulus Evodiae, Herba Cayatiae Japonicae, Radix berchemiae lineatae, Caulis et folium clerodendri bungei, Herba Gnaphalii Affinis, Herba Salviae Scapiformis, acanthopanax leucorrhizus Harms, cold syndrome of the stomach grass, Herba Piper Spuberuli, Phtheirospermum tenuisectum Bur.et Franch. merge, dosing Material weight ratio is the soak by water 2 times of 7～10 times amount, and each 0.5～2h filter, and merge twice filtrate, and concentrating under reduced pressure becomes the closeest Degree is the clear paste of 1.05～1.12, and addition 0.4～the chitosan solution of 0.6%, be 100～300r/min with rotating speed, during stirring Between 5～10min, cold preservation stand 6～18h, filter, filtrate becomes dried cream powder through drying under reduced pressure, sieves for subsequent use；
Take the fine powder in above-mentioned (1) and (2), (3), in dried cream powder, fully after mixing, obtain active Chinese drug component component, then Add adjuvant conventional on pharmaceutics and make various different oral formulations, to obtain final product.
Preferred as the present invention, the preparation method of described Chinese medicine preparation, it is to be prepared from by following steps:
(1) Radix Crotonis Crassifolii, Cortex erythrinae, Caulis Seu Folium Euonymi Fortunei are ground into 100 mesh fine powders, standby；
(2) take Radix Rubiae, geranium, with 60% ethanol infiltration, be that 8 times amount 60% ethanol carry out percolation by medical material weight ratio, receive Collection percolate, decompression recycling ethanol, concentrate, dried, and be ground into dried cream powder, sieve, medicinal residues are standby；
By the medicinal residues of (2) again with Herba Sarcandrae, Rhizoma Homalomenae, Herba Lysimachiae foenum-graeci, Herba Hyperici Sampsonii, Herba Aristolochiae Mollissimae, Bi, Herba Lycopodii, Adeps Bovis seu Bubali, Foliumet Ramulus Evodiae, Herba Cayatiae Japonicae, Radix berchemiae lineatae, Caulis et folium clerodendri bungei, Herba Gnaphalii Affinis, Herba Salviae Scapiformis, acanthopanax leucorrhizus Harms, cold syndrome of the stomach grass, Herba Piper Spuberuli, Phtheirospermum tenuisectum Bur.et Franch. merge, dosing Material weight ratio is the soak by water 2 times of 9 times amount, and each 1h filters, merges twice filtrate, and concentrating under reduced pressure becomes relative density to be 1.05 ～the clear paste of 1.12, add the chitosan solution of 0.5%, with rotating speed 200r/min, mixing time 8min, cold preservation stands 12h, filter Crossing, filtrate becomes dried cream powder through drying under reduced pressure, sieves for subsequent use；
(4) take the fine powder in above-mentioned (1) and (2), (3), in dried cream powder, fully after mixing, obtain active Chinese drug component component, Add adjuvant conventional on pharmaceutics and make various different oral formulations, to obtain final product.
Fang Zhong each side medicine source and efficacy effect are as follows:
Herba Sarcandrae, for the dry Herb of Chloranthaceae plant plait Corallium Japonicum Kishinouye Sarcandra glabra (Thunb.) Nakai.Property Taste is bitter, pungent, flat.Effect: clearing away heat and cooling blood, speckle removing of invigorating blood circulation, dispelling wind and removing obstruction in the collateral.
Radix Rubiae, for the dry root and rhizome of Maguireothamnus speciosus Radix Rubiae Rubia cordifolia L..Nature and flavor, bitter, cold.Merit Effect: removing heat from blood, hemostasis, blood stasis dispelling, stimulates the menstrual flow.
Rhizoma Homalomenae, puts down silk taro platymiscium Rhizoma Homalomenae Homalomena occulta (Lour.) Schott's for Araeceae Dry rhizome.Nature and flavor, bitter, pungent, temperature.Effect: wind-damp dispelling, muscle reinforcing and bone strengthening, promoting blood circulation and stopping pain.
Radix Crotonis Crassifolii, for Euphorbiaceae Fructus Crotonis platymiscium Radix Crotonis Crassifolii Croton crassifolius Geisel. [C.chinensis Benth.], is used as medicine with root.Nature and flavor, bitter, pungent, temperature.Effect: promoting the circulation of QI to relieve pain, detumescence of dispeling the wind.
Herba Lysimachiae foenum-graeci, for Primulaceae Lysimachia plant Herba Lysimachiae foenum-graeci Lysimachia foenum-graecum Hance with ground Upper all herbal medicine.Nature and flavor, sweet, light, flat.Effect: heat clearing away, circulation of qi promoting, pain relieving, drive ascarid.
Herba Hyperici Sampsonii, for the herb of Hypericaceae hypericum Herba Hyperici Sampsonii Hypericum sampsonii Hance.Property Taste, pungent, bitter, cold.Effect: heat-clearing and toxic substances removing, dredge the meridian passage, cooling blood for hemostasis.
Cortex erythrinae, for bark or the root bark of pulse family Erythrinae Arborescentis Erythrina indica Lam..Nature and flavor, bitter, flat.Merit Effect: wind-damp dispelling, channels sootheing and network vessel quickening.
Herba Aristolochiae Mollissimae, for the ground of Aristolochiaceae herbaceous plant Aristolochia mollissima AristolochiamollissimaHance Partly.Nature and flavor, pungent, bitter, flat.Effect: dispelling wind and removing obstruction in the collateral, pain relieving.
Bi, for the tuber of Dioscoreaceae Plant Powder back of the body Rhizoma Dioscoreae, Rhizoma Dioscoreae Hypoglaucae, mountain Bi or very thin Rhizoma Dioscoreae etc..Nature and flavor, bitter, Flat.Effect: dispel the wind, dampness removing.
Caulis Seu Folium Euonymi Fortunei, for Celastraceae burning buss Caulis Seu Folium Euonymi Fortunei Euonymus fortunei (Turcz.) Hand.-Mazz., It is used as medicine with stem, leaf.Effect: dissipating blood stasis stops blooding, relaxing muscles and tendons and activating QI and blood in the collateral.
Herba Lycopodii, for Menispermaceae Tinospora plant Tinospora sinensis Tinospora sinensis (Lour.) Merr., It is used as medicine with rattan.Nature and flavor, micro-hardship, cool.Effect: relaxing muscles and tendons and activating QI and blood in the collateral, wind-expelling pain-stopping.
Adeps Bovis seu Bubali, for Labiatae Origanum Adeps Bovis seu Bubali Origanum vulgare L., with all herbal medicine.Nature and flavor, pungent, temperature.Merit Effect: relieving the exterior syndrome by diaphoresis, removing dampness of relieving summer heat.
Foliumet Ramulus Evodiae, for Rutaceae Evodia plant Foliumet Ramulus Evodiae Evodia lepta (Spreng.) Merr., with root and leaf It is used as medicine.Nature and flavor, bitter, cold.Effect: heat-clearing and toxic substances removing, eliminating stasis to stop pain.
Herba Cayatiae Japonicae, for vitaceae Herba Cayatiae Japonicae Cayratia japonica (Thunb.) Gagnep., herb.Property Taste, bitter, sour, cold.Effect: removing toxic substances and promoting subsidence of swelling, promoting blood circulation to remove blood stasis, diuresis, hemostasis.
Radix berchemiae lineatae, for Rhamnaceae hook fold plant spire Radix Berchemiae Giraldianae Berchemia lineata (L.) DC., enters with root Medicine.Nature and flavor, micro-hardship, puckery, flat.Effect: removing stasis to stop bleeding, antitussive pain relieving.
Caulis et folium clerodendri bungei, for Verenaceae paulownia platymiscium Caulis et folium clerodendri bungei Clerodendrom bungei Steud., with root and leaf It is used as medicine.Nature and flavor, bitter, pungent, flat.Effect: expelling wind and removing dampness, detoxify dissipating blood stasis.
Herba Gnaphalii Affinis, for Compositae cottonweed Herba Gnaphalii Affinis Gnaphalium affine D.Don, herb.Nature and flavor, Sweet, flat.Effect: relieving cough and asthma, blood pressure lowering, wind-damp dispelling.
Herba Salviae Scapiformis, for the herb of labiate scape shape Radix Salviae Miltiorrhizae.Nature and flavor, pungent, flat.Effect: bone and muscle strengthening, qi-restoratives benefit Damage.
Geranium, for Huai Niuer Seedling section's plant cattle Seedling or Herba Erodii, nepal cranesbill, Siberia geranium and Carolina Cranesbill Herb, tuber person stork grass etc. are with the herb of fruit.Nature and flavor, toil, flat.Effect: dispel the wind, invigorates blood circulation, heat-clearing and toxic substances removing.
Acanthopanax leucorrhizus Harms, for the peel of stem of Araliaceae acanthopanax leucorrhizus Harms Acanthopanax leucorrhizrs (Oliv.) Harms Or root bark.Nature and flavor, acrid in the mouth；Micro-hardship；Warm in nature.Effect: wind-damp dispelling；The meridian dredging；Bone and muscle strengthening.
Cold syndrome of the stomach grass, for samphire Peucedanum morisonii Bess [P.songoricum auct.Non G.Don] root of your Radix Peucedani cold.Nature and flavor, acrid in the mouth；Effect warm in nature: expelling wind and cold；Regulating QI to relieve pain.
Herba Piper Spuberuli, for Piperaceae Piper vegetable hair Piper puberulum (Benth.) Maxim., is used as medicine with Herb. Nature and flavor, pungent, temperature.Effect: expelling wind and activating blood circulation, promoting the circulation of QI to relieve pain.
Phtheirospermum tenuisectum Bur.et Franch., for Scrophulariaceae Phtheirospermum plant Phtheirospermum tenuisectum Bur.et Franch. Phtheirospermum tenuisectum Bur.et Franch. with root, all herbal medicine.Nature and flavor, property is flat, and acrid in the mouth is bitter.Effect: tranquilizing by nourishing the heart, hemostasis.
The active constituent content measuring of Chinese medicine preparation of the present invention:
The Chinese medicine preparation prepared according to the embodiment of the present invention 1 method carries out composition measurement: wherein total polysaccharides: use anthrone- Sulfuric acid process, is measured；Total flavones: using with sodium nitrite-aluminum nitrate-sodium-hydroxide method ultraviolet determination, its measurement result is shown in Table 1.
Table 1 Chinese medicine preparation of the present invention Major Components result
The beneficial effect of Chinese medicine preparation of the present invention:
Each crude drug component in Chinese medicine preparation of the present invention and proportioning thereof, be through the application differential diagnosis in tcm compatibility and clinical warp Test what summary groped out.Its each medical material compatibility complements each other using, and has synergism.All medicines share play altogether invigorate blood circulation logical Network, invigorating the spleen and benefiting QI, dispersing cold for relieving pain, effect of invigorating the kidney and strengthening the bones.Prepared by the employing modern Chinese medicine extraction purification of Chinese medicine preparation of the present invention Technology, scientific and reasonable so that the effective ingredient (total polysaccharides and total flavones) of Chinese medicine preparation of the present invention is leached out completely, with Obtain active ingredient of Chinese herbs of the present invention.And process of preparing of the present invention is simple, operating feasible, easy technology produces.
According to clinical verification, the effective percentage of the clinical cure of the Chinese medicine preparation of the present invention is up to 92.42%, through 3 courses for the treatment of Treatment after, the clinical symptoms for the treatment of group patient goes out pain, swelling, tenderness, deadlock index in morning all have clear improvement, and treatment group is suffered from The erythrocyte sedimentation rate (ESR) of person, rheumatoid factor (RF), the index of C mono-reactive protein (CRP) have declined, and these further illustrate, The safety of the Chinese medicine preparation of the present invention and effectiveness, clinic is applied and promotes.
Detailed description of the invention
The following is the specific embodiment of present invention, for illustrating the skill of technical problem to be solved in present specification Art scheme, contributes to skilled artisan understands that present invention, but the realization of technical solution of the present invention is not limited to these Embodiment.
Embodiment 1
(1), by Radix Crotonis Crassifolii 100g, Cortex erythrinae 60g, Caulis Seu Folium Euonymi Fortunei 80g, it is ground into 100 mesh fine powders, standby；
(2) take Radix Rubiae 120g, geranium 40g, with 60% ethanol infiltration, be that 8 times amount 60% ethanol are carried out by medical material weight ratio Percolation, collects percolate, decompression recycling ethanol, concentrates, dried, and is ground into dried cream powder, sieves, and medicinal residues are standby；
By the medicinal residues of (2) again with Herba Sarcandrae 120g, Rhizoma Homalomenae 100g, Herba Lysimachiae foenum-graeci 60g, Herba Hyperici Sampsonii 50g, Herba Aristolochiae Mollissimae 50g, Bi 80g, Herba Lycopodii 40g, Adeps Bovis seu Bubali 30g, Foliumet Ramulus Evodiae 60g, Herba Cayatiae Japonicae 60g, Radix berchemiae lineatae 40g, Caulis et folium clerodendri bungei 60g, Herba Gnaphalii Affinis 60g, Herba Salviae Scapiformis 40g, acanthopanax leucorrhizus Harms 30g, cold syndrome of the stomach grass 40g, Herba Piper Spuberuli 40g, Phtheirospermum tenuisectum Bur.et Franch. 20g merge, and add the decocting that medical material weight ratio is 9 times amount Boil 2 times, each 1h, filter, merge twice filtrate, the clear paste that concentrating under reduced pressure becomes relative density to be 1.05～1.12, add 0.5% Chitosan solution, with rotating speed 200r/min, mixing time 8min, cold preservation stands 12h, filters, and filtrate is through drying under reduced pressure Cheng Gan Cream powder, sieves for subsequent use；
(4) take the fine powder in above-mentioned (1) and (2), (3), in dried cream powder, fully after mixing, add appropriate carboxymethyl Starch Sodium, magnesium stearate, mixing, pelletize, be pressed into 1000 tablets.
Embodiment 2
(1), by Radix Crotonis Crassifolii 110g, Cortex erythrinae 50g, Caulis Seu Folium Euonymi Fortunei 50g, it is ground into 100 mesh fine powders, standby；
(2) take Radix Rubiae 130g, geranium 50g, with 70% ethanol infiltration, be that 7 times amount 70% ethanol are carried out by medical material weight ratio Percolation, collects percolate, decompression recycling ethanol, concentrates, dried, and is ground into dried cream powder, sieves, and medicinal residues are standby；
By the medicinal residues of (2) again with Herba Sarcandrae 130g, Rhizoma Homalomenae 90g, Herba Lysimachiae foenum-graeci 50g, Herba Hyperici Sampsonii 60g, Herba Aristolochiae Mollissimae 40g, Bi 90g, Herba Lycopodii 30g, Adeps Bovis seu Bubali 20g, Foliumet Ramulus Evodiae 70g, Herba Cayatiae Japonicae 60g, Radix berchemiae lineatae 50g, Caulis et folium clerodendri bungei 40g, Herba Gnaphalii Affinis 50g, Herba Salviae Scapiformis 30g, acanthopanax leucorrhizus Harms 40g, cold syndrome of the stomach grass 30g, Herba Piper Spuberuli 30g, Phtheirospermum tenuisectum Bur.et Franch. 10g merge, and add the water that medical material weight ratio is 10 times amount Decoct 2 times, each 2h, filter, merge twice filtrate, the clear paste that concentrating under reduced pressure becomes relative density to be 1.05～1.12, add The chitosan solution of 0.6%, with rotating speed as 100r/min, mixing time 10min, cold preservation stands 6h, filters, and filtrate is dry through decompression Dry one-tenth dried cream powder, sieves for subsequent use；
(4), after taking the fine powder in above-mentioned (1) and the dried cream powder in (2), (3), fully mixing, add appropriate dextrin, micro- Crystalline cellulose, mixing, pelletize, be dried, make 1000 dispersants.
Embodiment 3
(1), by Radix Crotonis Crassifolii 90g, Cortex erythrinae 70g, Caulis Seu Folium Euonymi Fortunei 70g, it is ground into 100 mesh fine powders, standby；
(2) take Radix Rubiae 110g, geranium 30g, with 50% ethanol infiltration, be that 9 times amount 50% ethanol are carried out by medical material weight ratio Percolation, collects percolate, decompression recycling ethanol, concentrates, dried, and is ground into dried cream powder, sieves, and medicinal residues are standby；
By the medicinal residues of (2) again with Herba Sarcandrae 110g, Rhizoma Homalomenae 110g, Herba Lysimachiae foenum-graeci 70g, Herba Hyperici Sampsonii 40g, Herba Aristolochiae Mollissimae 60g, Bi 70g, Herba Lycopodii 50g, Adeps Bovis seu Bubali 40g, Foliumet Ramulus Evodiae 50g, Herba Cayatiae Japonicae 40g, Radix berchemiae lineatae 30g, Caulis et folium clerodendri bungei 60g, Herba Gnaphalii Affinis 70g, Herba Salviae Scapiformis 50g, acanthopanax leucorrhizus Harms 20g, cold syndrome of the stomach grass 50g, Herba Piper Spuberuli 50g, Phtheirospermum tenuisectum Bur.et Franch. 30g merge, and add the decocting that medical material weight ratio is 7 times amount Boil 2 times, each 0.5h, filter, merge twice filtrate, the clear paste that concentrating under reduced pressure becomes relative density to be 1.05～1.12, add The chitosan solution of 0.4%, with rotating speed as 300r/min, mixing time 5min, cold preservation stands 18h, filters, and filtrate is dry through decompression Dry one-tenth dried cream powder, sieves for subsequent use；
(4), after taking the fine powder in above-mentioned (1) and the dried cream powder in (2), (3), fully mixing, add appropriate starch, phosphorus Acid dihydride calcium, pelletizes, encapsulated, makes 1000 hard capsules.
In order to verify the curative effect of Chinese medicine preparation of the present invention further, we are by the tablet of preparation in above-mentioned specific embodiment 1, Carrying out clinical trial, its clinical test results is reported as follows.
The clinical observation of Chinese medicine preparation of the present invention and curative effect
1. physical data
Accept rheumatoid arthritis card patient's totally 129 example for medical treatment, be randomly divided into treatment group and matched group.Wherein treatment group 66 Example, male 34 examples, female 32 example, age 45～77 years old, 60.5 ± 3.9 years old mean age, average course of disease 5.1 ± 1.8 years；Matched group 63 Example, male 35 examples, female 28 example, age 47～76 years old, 61.6 ± 2.1 years old mean age, average course of disease 4.8 ± 1.5 years；Two groups of patients Through statistical procedures no significant difference (P ＞ 0.05) between age, the course of disease, severity extent, there is comparability.
2. diagnostic criteria
2.1 tcm diagnosis standards
1. joint swelling and pain, miserable numbness, tenderness, dysfunction, Mental fatigue face is grey, dizziness；2. meet wet weather, cold, scrape Wind weather aggravation；3. light red tongue has ecchymosis petechia, and tongue is the most greasy or HUANGBAI(sic) is alternate, soft and rapid pulse or heavy string；All possess above 1～ 3 persons can dialectical be just (Liver and kidney QI and blood) exogenous pathogen (the wind and cold wet hot phlegm stasis of blood) excess syndrome type.But get rid of following case: 1. merge the heart, The severe primary disease patients such as liver, kidney, brain and hemopoietic system；2. gestation or person's age of sucking；The most not by regulation medication, it is impossible to judge The infull person of curative effect or data.
2.2 Therapeutic Method
Treatment group: the patient that embodiment is 1 group gives the Chinese medicinal tablet of the embodiment of the present invention 1 group, oral, three times a day, every time 5 dosage units, 4 weeks are a course for the treatment of, serve on 3 courses for the treatment of.Other drug is withdrawn during treating.
Matched group: give double rattan JINGU PIAN (Shaanxi Mo Mei get pharmaceutical Co. Ltd), each 5, three times a day, 4 Zhou Weiyi The individual course for the treatment of, after serveing on 3 courses for the treatment of, observe symptom and the therapeutic effect of two groups of patients.
2.3 observation index
1. Clinical symptom and sign: joint swelling and pain, Disability index, morning is stiff and 15m walking time, hand-grip strength； 2. lab testing: erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), C mono-reactive protein (CRP), x-ray take the photograph sheet etc., before treatment, treats Within latter 3 months, respectively look into once.
2.4 curative effect determinate standard
Clinical remission: morning is stiff, and < 15min, without weak, without arthralgia and tenderness, without arthroncus.ESR male < 20mm/ H, women < 30mm/h；At least up to 4 persons in above 5；Effective: morning is stiff, arthralgia and tenderness number, arthroncus number, both hands Average grip, the every progress of ESR and (or) CRP 50%, the 15m walking time shortens 3S, RF decline 30%, in above 7 at least Reach 4 persons；Effective: to reach 3 persons in effective standard 7；Invalid: not reach 3 in effective standard 7 or the state of an illness is disliked Change person.
2.5 statistical analysis
Using statistic software SPSS 13.0 to process data, use inspection, P < 0.05 is statistically significant.
2.6 therapeutic outcome
3.1 result of the tests are shown in Table 2.
Table 2 clinical effectiveness comparison sheet
Note: compared with matched group,△P ＜ 0.05,△△P ＜ 0.01.
From the experimental result of table 1, the total effective rate for the treatment of group patient of the present invention is 92.42% to treat
The total effective rate of group is only 71.43%, and treatment group curative effect is superior to matched group, and have significant difference ((P < 0.05)。
Before and after the group treatment of 3 liang of table, clinical symptoms and function of joint situation of change compare
Note: with this group before treatment, * P ＜ 0.05, * * P ＜ 0.01, compared with matched group,△P ＜ 0.05,△△P ＜ 0.01。
As shown in table 3 by experimental result, two groups of patients after the treatment of 3 courses for the treatment of, the clinical symptoms for the treatment of group patient As pain, swelling, tenderness, deadlock index in morning all have clear improvement (P < 0.01)；Matched group is except having pain, swelling, tenderness, deadlock in morning Outside improvement, remaining symptom is improved the most inconspicuous.Two groups treatment after indices comparing difference all have significance (P < 0.01 or P < 0.05)。
Before and after the group treatment of 4 liang of table, laboratory parameters situation of change compares
Note: with this group before treatment, * P ＜ 0.05, * * P ＜ 0.01, compared with matched group,△P ＜ 0.05,△△P ＜ 0.01。
As shown in Table 4, after trimestral treatment, before and after treatment group patient treatment, indices compares, all Being decreased obviously (P < 0.01), compare with matched group, ESR, RF and CRP for the treatment of group patient declines change in value, has significance Difference (P < 0.05), two groups of comparison therapy groups are substantially better than matched group (P < 0.05 or P < 0.01).
3.2 untoward reaction trace analysises
Except matched group has 3 examples stomach discomfort occur, continual cure was alleviated after 1 week.And treatment group 66 example patient of the present invention In clinical observation, do not find any untoward reaction and toxicity.
In sum, Chinese medicine preparation of the present invention has an anti-inflammatory and antalgic, immunomodulating and improve the effects such as microcirculation, delays Solve the joint of rheumatic arthritis, numb, stiff, the disease swollen and ache.And in terms for the treatment of rheumatoid arthritis disease, there is treatment The feature that effect is definite, notable, have no side effect, clinic popularization and application.

Claims (7)

1. the Chinese medicine preparation treating rheumatoid arthritis, it is characterised in that it is by the crude drug of following weight proportion Make: Herba Sarcandrae 110～130 parts, Radix Rubiae 110～130 parts, Rhizoma Homalomenae 90～110 parts, Radix Crotonis Crassifolii 90～110 parts, Herba Lysimachiae foenum-graeci 50 ～70 parts, Herba Hyperici Sampsonii 40～60 parts, Cortex erythrinae 50～70 parts, Herba Aristolochiae Mollissimae 40～60 parts, Bi 70～90 parts, Caulis Seu Folium Euonymi Fortunei 50～70 Part, Herba Lycopodii 30～50 parts, Adeps Bovis seu Bubali 20～40 parts, Foliumet Ramulus Evodiae 50～70 parts, Herba Cayatiae Japonicae 40～60 parts, Radix berchemiae lineatae 30～50 parts, Caulis et folium clerodendri bungei 40～60 parts, Herba Gnaphalii Affinis 50～70 parts, Herba Salviae Scapiformis 30～50 parts, geranium 30～50 parts, acanthopanax leucorrhizus Harms 20～40 parts, stomach Cold grass 30～50 parts, Herba Piper Spuberuli 30～50 parts, Phtheirospermum tenuisectum Bur.et Franch. 10～30 parts.
2. the Chinese medicine preparation treating rheumatoid arthritis as claimed in claim 1, it is characterised in that it is by following weight The crude drug of proportioning is made: Herba Sarcandrae 120 parts, 120 parts of Radix Rubiae, Rhizoma Homalomenae 100 parts, Radix Crotonis Crassifolii 100 parts, Herba Lysimachiae foenum-graeci 60 parts, unit Precious grass 50 parts, Cortex erythrinae 60 parts, Herba Aristolochiae Mollissimae 50 parts, Bi 80 parts, Caulis Seu Folium Euonymi Fortunei 80 parts, Herba Lycopodii 40 parts, Adeps Bovis seu Bubali 30 parts, Foliumet Ramulus Evodiae 60 parts, Herba Cayatiae Japonicae 60 parts, Radix berchemiae lineatae 40 parts, Caulis et folium clerodendri bungei 60 parts, Herba Gnaphalii Affinis 60 parts, Herba Salviae Scapiformis 40 parts, geranium 40 parts, acanthopanax leucorrhizus Harms 30 parts, cold syndrome of the stomach grass 40 parts, Herba Piper Spuberuli 40 parts, Phtheirospermum tenuisectum Bur.et Franch. 20 parts.
3. the Chinese medicine preparation treating rheumatoid arthritis as claimed in claim 1, it is characterised in that it is by following weight The crude drug of proportioning is made: Herba Sarcandrae 130 parts, 130 parts of Radix Rubiae, Rhizoma Homalomenae 90 parts, Radix Crotonis Crassifolii 110 parts, Herba Lysimachiae foenum-graeci 50 parts, ingot Grass 60 parts, Cortex erythrinae 50 parts, Herba Aristolochiae Mollissimae 40 parts, Bi 90 parts, Caulis Seu Folium Euonymi Fortunei 50 parts, Herba Lycopodii 30 parts, Adeps Bovis seu Bubali 20 parts, Foliumet Ramulus Evodiae 70 Part, Herba Cayatiae Japonicae 60 parts, Radix berchemiae lineatae 50 parts, Caulis et folium clerodendri bungei 40 parts, Herba Gnaphalii Affinis 50 parts, Herba Salviae Scapiformis 30 parts, geranium 50 parts, acanthopanax leucorrhizus Harms 40 Part, cold syndrome of the stomach grass 30 parts, Herba Piper Spuberuli 30 parts, Phtheirospermum tenuisectum Bur.et Franch. 10 parts.
4. the Chinese medicine preparation treating rheumatoid arthritis as claimed in claim 1, it is characterised in that it is by following weight The crude drug of proportioning is made: Herba Sarcandrae 110 parts, 110 parts of Radix Rubiae, Rhizoma Homalomenae 110 parts, Radix Crotonis Crassifolii 90 parts, Herba Lysimachiae foenum-graeci 70 parts, ingot Grass 40 parts, Cortex erythrinae 70 parts, Herba Aristolochiae Mollissimae 60 parts, Bi 70 parts, Caulis Seu Folium Euonymi Fortunei 70 parts, Herba Lycopodii 50 parts, Adeps Bovis seu Bubali 40 parts, Foliumet Ramulus Evodiae 50 Part, Herba Cayatiae Japonicae 40 parts, Radix berchemiae lineatae 30 parts, Caulis et folium clerodendri bungei 60 parts, Herba Gnaphalii Affinis 70 parts, Herba Salviae Scapiformis 50 parts, geranium 30 parts, acanthopanax leucorrhizus Harms 20 Part, cold syndrome of the stomach grass 50 parts, Herba Piper Spuberuli 50 parts, Phtheirospermum tenuisectum Bur.et Franch. 30 parts.
5. as described in Claims 1 to 4 is arbitrary, treat the Chinese medicine preparation of rheumatoid arthritis, it is characterised in that described Chinese medicine Preparation adds tablet that pharmaceutic adjuvant conventional on pharmaceutics makes, dispersible tablet, capsule, drop pill, granule.
6. treating the preparation method of the Chinese medicine preparation of rheumatoid arthritis as described in Claims 1 to 4 is arbitrary, its feature exists In, it is to be prepared from by following steps:
(1) Radix Crotonis Crassifolii, Cortex erythrinae, Caulis Seu Folium Euonymi Fortunei are ground into fine powder, standby；
(2) take Radix Rubiae, geranium, with 50%～70% ethanol infiltration, be 7～9 times amount 50%～70% ethanol by medical material weight ratio Carrying out percolation, collect percolate, decompression recycling ethanol, concentrate, dried, and be ground into dried cream powder, sieve, medicinal residues are standby；
By the medicinal residues of (2) again with Herba Sarcandrae, Rhizoma Homalomenae, Herba Lysimachiae foenum-graeci, Herba Hyperici Sampsonii, Herba Aristolochiae Mollissimae, Bi, Herba Lycopodii, Adeps Bovis seu Bubali, trident Hardship, Herba Cayatiae Japonicae, Radix berchemiae lineatae, Caulis et folium clerodendri bungei, Herba Gnaphalii Affinis, Herba Salviae Scapiformis, acanthopanax leucorrhizus Harms, cold syndrome of the stomach grass, Herba Piper Spuberuli, Phtheirospermum tenuisectum Bur.et Franch. merge, and add medical material weight Amount than being the soak by water 2 times of 7～10 times amount, each 0.5～2h, filter, merge twice filtrate, concentrating under reduced pressure becomes the relative density to be The clear paste of 1.05～1.12, adds 0.4～the chitosan solution of 0.6%, is 100～300r/min with rotating speed, mixing time 5～ 10min, cold preservation stands 6～18h, filters, and filtrate becomes dried cream powder through drying under reduced pressure, sieves for subsequent use；
(3) take the fine powder in above-mentioned (1) and (2), (3), in dried cream powder, fully after mixing, obtain active Chinese drug component component, then add Enter adjuvant conventional on pharmaceutics and make various different oral formulations, to obtain final product.
7. the preparation method of the as claimed in claim 6 Chinese medicine preparation for the treatment of rheumatoid arthritis, it is characterised in that it be by Following steps are prepared from:
(1) Radix Crotonis Crassifolii, Cortex erythrinae, Caulis Seu Folium Euonymi Fortunei are ground into 100 mesh fine powders, standby；
(2) taking Radix Rubiae, geranium, with 60% ethanol infiltration, be that 8 times amount 60% ethanol carry out percolation by medical material weight ratio, collection is oozed Filter liquid, decompression recycling ethanol, concentrate, dried, and be ground into dried cream powder, sieve, medicinal residues are standby；
By the medicinal residues of (2) again with Herba Sarcandrae, Rhizoma Homalomenae, Herba Lysimachiae foenum-graeci, Herba Hyperici Sampsonii, Herba Aristolochiae Mollissimae, Bi, Herba Lycopodii, Adeps Bovis seu Bubali, trident Hardship, Herba Cayatiae Japonicae, Radix berchemiae lineatae, Caulis et folium clerodendri bungei, Herba Gnaphalii Affinis, Herba Salviae Scapiformis, acanthopanax leucorrhizus Harms, cold syndrome of the stomach grass, Herba Piper Spuberuli, Phtheirospermum tenuisectum Bur.et Franch. merge, and add medical material weight Amount than being the soak by water 2 times of 9 times amount, each 1h, filter, merge twice filtrate, concentrating under reduced pressure become relative density be 1.05～ The clear paste of 1.12, adds the chitosan solution of 0.5%, and with rotating speed 200r/min, mixing time 8min, cold preservation stands 12h, filter Crossing, filtrate becomes dried cream powder through drying under reduced pressure, sieves for subsequent use；
(4) take the fine powder in above-mentioned (1) and (2), (3), in dried cream powder, fully after mixing, obtain active Chinese drug component component, then add Enter adjuvant conventional on pharmaceutics and make various different oral formulations, to obtain final product.
CN201610472023.1A 2016-06-23 2016-06-23 Traditional Chinese medicine preparation for treating rheumatoid arthritis Withdrawn CN106038912A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1861155A (en) * 2006-04-18 2006-11-15 钟龙 Method for preparing traditional Chinese medicine for treating rheumatism and rheumatoid disease, and said medicine thereby
CN101264256A (en) * 2008-04-26 2008-09-17 朱序金 Chinese medicine capsule for treating intractable pain
CN103816450A (en) * 2014-03-12 2014-05-28 张利民 Traditional Chinese medicine for treating rheumatoid arthritis
CN105327024A (en) * 2015-12-02 2016-02-17 张莉 Traditional Chinese medicine preparation for treating rheumatoid arthritis

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1861155A (en) * 2006-04-18 2006-11-15 钟龙 Method for preparing traditional Chinese medicine for treating rheumatism and rheumatoid disease, and said medicine thereby
CN101264256A (en) * 2008-04-26 2008-09-17 朱序金 Chinese medicine capsule for treating intractable pain
CN103816450A (en) * 2014-03-12 2014-05-28 张利民 Traditional Chinese medicine for treating rheumatoid arthritis
CN105327024A (en) * 2015-12-02 2016-02-17 张莉 Traditional Chinese medicine preparation for treating rheumatoid arthritis

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