CN103285343B - Medicine for treating liver cancer and preparation method thereof - Google Patents

Abstract

The invention discloses a medicine for treating a liver cancer and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. The medicine is prepared from the following raw material by weight: 10 g of virgate wormwood herb, 6 g of root of large-flowered skullcap, 10 g of mulberry bark, 6 g of licorice, 5 g of toad skin, 4 g of common aucklandia root, 8 g of zedoray rhizome, 11 g of ginkgo leaf, 9 g of curcuma tuber, 8 g of Chinese asafetida, 8 g of peach seed, 10 g of Patrinia heterophylla, 12 g of sarcandra, 10 g of Chinese lobelia herb, 9 g of dried orange peel, 10 g of sarcandra glabra, 10 g of Chinese angelica, 20 g of milkvetch root, 18 g of hawthorn fruit, 8 g of dried ginger, 15 g of turtle carapace, 15 g of heydyotis and 10 g of bighead atractylodes rhizome. The preparation method comprises the following steps: water extraction, alcohol extraction and fabrication of a capsule. The medicine has the effects of heat clearing, detoxifying, blood activating, stasis dissolving, phlegm eliminating, collateral dredging, hardness softening, bind dissipating, healthy energy supporting and root securing, exerts a definite therapeutic effect on the liver cancer and has little toxic and side effects.

Description

Medicine of a kind of Hepatoma therapy and preparation method thereof

Technical field

The present invention relates to medicine of a kind of Hepatoma therapy and preparation method thereof, belong to technical field of Chinese medicines.

Background technology

Hepatocarcinoma refers to the malignant tumor betiding liver, comprises primary hepatocarcinoma and secondary liver cancer two kinds, and mostly what the hepatocarcinoma of the daily theory of people referred to is primary hepatocarcinoma.Primary hepatocarcinoma is one of modal malignant tumor clinically, and according to recent statistics, liver cancer patient about 600,000 is newly sent out in the whole world every year, occupies the 5th of malignant tumor.Primary hepatocarcinoma can be divided into Hepatocellular carcinoma, intrahepatic cholangiocarcinoma and mixed carcinoma of liver by cell typing.China is hepatitis B big country, and the hepatocarcinoma of China is many to be developed on the basis of hbv-liver cirrhosis, and hepatitis C patient is also increasing gradually, also can develop into hepatocarcinoma after hepatitis B.Current China number of the infected accounts for the more than half of the whole world, and account for 55% of global hepatocarcinoma patient, become a large killer of serious threat our people health and lives, its danger can not look down upon.In general the method for operative treatment is all adopted, but a lot of patient can not be treated surgically due to a variety of causes, and the danger of operative treatment is also larger, in addition, Drug therapy great majority adopt Western medicine, the therapeutic effect of Western medicine is also not obvious, and have side effect, often with complication, price is also somewhat expensive, general family is difficult to bear economic pressures, has delayed the golden hour of patient.Treatment by Chinese herbs is relatively safe, expense is low, at present, a lot of Chinese medicine formula about Hepatoma therapy has been there is in tcm field, but, the real root that these formula can not find hepatocarcinoma to show effect, therapeutic effect is also not obvious, after patient takes, cure rate and obvious effective rate are all lower, are difficult problems of the Chinese medicine formula of current Hepatoma therapy.

Summary of the invention

The present invention is on pathogenetic basis of further investigation hepatocarcinoma, develop medicine of a kind of Hepatoma therapy and preparation method thereof, this medicine all adopts pure natural Chinese herbal medicine, have no side effect, determined curative effect, can more effective Hepatoma therapy, this preparation method fully can extract the effective ingredient of medicine, reaches better effect.

The technical scheme that technical solution problem of the present invention is taked is:

A kind of medicine of Hepatoma therapy, it is characterized in that, be made up of the crude drug of following weight: Herba Artemisiae Scopariae 10g, Radix Scutellariae 6g, Cortex Mori 10g, Radix Glycyrrhizae 6g, Cutis Bufonis 5g, Radix Aucklandiae 4g, Rhizoma Curcumae 8g, Folium Ginkgo 11g, Radix Curcumae 9g, Resina Ferulae 8g, Semen Persicae 8g, Radix Patriniae heterophyllae 10g, Herba Sarcandrae 12g, Herba Lobeliae Chinensis 10g, Pericarpium Citri Reticulatae 9g, Herba Pileae Scriptae 10g, Radix Angelicae Sinensis 10g, Radix Astragali 20g, Fructus Crataegi 18g, Rhizoma Zingiberis 8g, Carapax Trionycis 15g, Herba Hedyotidis Diffusae 15g, Rhizoma Atractylodis Macrocephalae 10g.

The preparation method of the medicine of above-mentioned Hepatoma therapy, is characterized in that, comprises the following steps:

S1: prepare each raw material by above-mentioned weight;

S2: get ready Herba Artemisiae Scopariae, Radix Scutellariae, Cortex Mori, Cutis Bufonis, the Radix Aucklandiae, Rhizoma Curcumae, Folium Ginkgo, Radix Curcumae, Resina Ferulae, Semen Persicae, Radix Patriniae heterophyllae, Herba Sarcandrae, Herba Lobeliae Chinensis, Pericarpium Citri Reticulatae, Herba Pileae Scriptae, Radix Angelicae Sinensis, the Radix Astragali, Rhizoma Zingiberis, Carapax Trionycis, Herba Hedyotidis Diffusae and the Rhizoma Atractylodis Macrocephalae in the S1 step of half weight, put into marmite, add the soak by water 50min of 2.5 times, filter, obtain filtrate one, filtering residue puts back to marmite, adds 1.5 times of soak by water 30min, filter, obtain filtrate two; Merging filtrate one and filtrate two, distilling under reduced pressure, be concentrated into the thick paste that relative density is 1.19 ~ 1.38, then infrared drying, wears into fine powder, is medicated powder one;

S3: get ready Herba Artemisiae Scopariae, Radix Scutellariae, Cortex Mori, Cutis Bufonis, the Radix Aucklandiae, Rhizoma Curcumae, Folium Ginkgo, Radix Curcumae, Resina Ferulae, Semen Persicae, Radix Patriniae heterophyllae, Herba Sarcandrae, Herba Lobeliae Chinensis, Pericarpium Citri Reticulatae, Herba Pileae Scriptae, Radix Angelicae Sinensis, the Radix Astragali, Rhizoma Zingiberis, Carapax Trionycis, Herba Hedyotidis Diffusae and the Rhizoma Atractylodis Macrocephalae in the S1 step of second half weight, pulverize, then alcohol extraction is carried out with the ethanol of 45%, alcohol extract is carried out distilling under reduced pressure under 40 DEG C of conditions, be concentrated into the thick paste that relative density is 1.14 ~ 1.34, then infrared drying, wearing into fine powder, is medicated powder two;

S4: Fructus Crataegi ready in S1 step and Radix Glycyrrhizae are worn into fine powder, crosses 80 mesh sieves, obtains medicated powder three;

S5: by above-mentioned medicated powder one, medicated powder two, medicated powder three mix homogeneously, incapsulate, every capsules loads 0.4g.

The instructions of taking of above-mentioned capsule: every day twice, each 3 ~ 6.

The Chinese pathology of hepatocarcinoma: according to clinical manifestation, hepatocarcinoma can belong to the category such as the traditional Chinese medical science " tympanites ", " jaundice ", " gathering ", " hypochondriac pain ", " the liver rump ", " lump at the left hypochondrium ", " pneumatosis ", " fullness in the epigastrium especially referring to the abcess of the abdomen in ancient times ".The prerequisite that hepatocarcinoma occurs is that healthy energy is deficient, zang-fu disharmony, what hepatocarcinoma developed is then because raw in cancer poison, evil poison are illegally occupied, the resistance of qi depression to blood stasis, channels numbness is then the major reason of hepatocarcinoma development, turbid, all heresy of wet hot phlegm attack mutually be its occur development pathogenic key, liver and gall taste, for a long time must and kidney, be that the pathological changes internal organs of liver cancer genesis and development are theoretical.Common disease is generally liver blood stasis, deficiency of spleen-QI, stagnation of QI due to depression of the liver, incoordination between the liver and stomach, damp-heat in the spleen and stomach, deficiency of liver-YIN, deficiency of the kidney yin etc.Therefore, treating the liver cancer will coordinate conditioning from each internal organs, a treating the liver that can not isolate and ignore other internal organs.In raw material of Chinese medicine of the present invention, such as: Herba Artemisiae Scopariae, Radix Scutellariae heat-clearing and toxic substances removing, Rhizoma Curcumae, Semen Persicae, Resina Ferulae, Radix Curcumae etc. are for blood circulation promoting and blood stasis dispelling, above-mentioned several material combined effect, the continuation development of hepatocarcinoma is hindered to worsen, the hard masses softening and resolving such as the Radix Aucklandiae, Rhizoma Zingiberis Recens, the strengthening the body resistance such as the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, the Radix Astragali, eliminate or weaken the prerequisite that hepatocarcinoma occurs on the one hand, on the other hand body is played to the effect of solidification consolidation, each medicine is coordinated mutually, from the various aspects Comprehensive Treatment of onset of liver cancer, to reach good curative effect.

The pharmacological action of each Chinese medicine:

Herba Artemisiae Scopariae: bitter, pungent, is slightly cold.Return spleen, stomach, liver, gallbladder meridian.Function cures mainly: clearing away damp-heat, jaundice eliminating subcutaneous ulcer.For jaundice oliguria, eczema pruritus; Infectious jaundice type hepatitis.

Radix Scutellariae: bitter, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.

Cortex Mori: sweet, cold.Return lung meridian.Function cures mainly: eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.For dyspnea and cough due to lung-heat, edema distension oliguria, appearance skin edema.

Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Function with cure mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Cutis Bufonis: bitter in the mouth; Cool in nature; Poisonous, GUIXIN; Lung; Spleen; Large intestine channel, function cures mainly: heat-clearing and toxic substances removing; Inducing diuresis to remove edema.Main carbuncle; Toxic swelling; Scrofula; Swollen scrofula; Infantile malnutrition abdominal distention; Chronic tracheitis.

The Radix Aucklandiae: pungent, bitter, temperature.Return spleen, stomach, large intestine, three burnt, gallbladder meridians.Function cures mainly: promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.For breast gastral cavity distending pain, heavy after dysentery, food stagnation does not disappear, anorexia.The real intestinal antidiarrheal of Radix Aucklandiae (roasted).For stomachache of having loose bowels.

Rhizoma Curcumae: pungent, bitter, temperature.Return liver, spleen channel.Function cures mainly: circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For Dan abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.

Folium Ginkgo: sweet, bitter, puckery is flat.GUIXIN, lung meridian.Function with cure mainly: astringe the lung, relieving asthma, blood circulation promoting and blood stasis dispelling, pain relieving.For cough and asthma due to lung deficiency; Coronary heart disease, angina pectoris, hyperlipidemia.

Radix Curcumae: arduous, cool.Enter the heart, lung, Liver Channel.Function with cure mainly: promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs, controls breast abdomen side of body rib all pains, loses the heart demented, calentura coma. spit blood, jaundice.

Resina Ferulae: bitter, pungent, temperature.Return spleen, stomach warp.Function cures mainly: removing food stagnancy, loose painful abdominal mass, parasite killing.For meat stagnation, blood stasis lump in the abdomen, mass in abdomen, abdominal pain due to worm stagnation.

Semen Persicae: bitter, sweet, flat.GUIXIN, liver, large intestine channel.Function cures mainly: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.For amenorrhea, dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation.

Radix Patriniae heterophyllae: bitter in the mouth; Micro-sour and astringent; Cool in nature, GUIXIN; Liver Channel, function cures mainly: dampness leukorrhagia stopping; Astringing to arrest bleeding; Heat-clearing and toxic substances removing.Main leucorrhea with red and white discharge; Metrorrhagia; Dysentery; Jaundice; Malaria; Intestinal carbuncle; Sore swollen toxin; Traumatic injury; Cervical cancer; Gastric cancer.

Herba Sarcandrae: bitter; Pungent; Flat, GUIXIN, Liver Channel, function cures mainly: expelling wind and removing dampness; Promoting blood circulation to remove blood stasis; Heat-clearing and toxic substances removing.Main numb limbs and tense tendons; Traumatic injury; Fracture; Dysmenorrhes; The stagnant stomachache of the stasis of blood in puerperal; Pneumonia; Striving property appendicitis; Acute gastroenteritis; Bacillary dysentery; Cholecystitis; Pus swells; Stomatitis; Rheumatic arthralgia.

Herba Lobeliae Chinensis: pungent, flat.GUIXIN, small intestinal, lung meridian.Function cures mainly: inducing diuresis to remove edema, heat-clearing and toxic substances removing.For extensive abdominal edema, face foot edema, carbuncle furuncle, snake bite and insect sting; Advanced schistosomiasis ascites.

Pericarpium Citri Reticulatae: bitter, pungent, temperature.Return lung, spleen channel.Function cures mainly: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.

Herba Pileae Scriptae: nature and flavor: bitter; Pungent; Flat.Heart channel, Liver Channel.Function cures mainly: anti-inflammation, expelling wind and removing dampness, promoting blood circulation and stopping pain.Control pneumonia, acute appendicitis, acute gastroenteritis, bacillary dysentery, rheumatalgia, traumatic injury, fracture, tumor.

Radix Angelicae Sinensis: sweet, acrid, warm.Enter the heart, liver, spleen channel.Function with cure mainly: benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturizes laxation.Control menoxenia, amenorrhea is suffered from abdominal pain, and lump in the abdomen knot is poly-, metrorrhagia; Headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome; Dryness of the intestine dyschezia is heavy after bloody dysentery; Carbuncle skin ulcer is stolen, injury from falling down.

The Radix Astragali: sweet, temperature.Return lung, spleen channel.Function with cure mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.

Fructus Crataegi: sour, sweet, tepor.Return spleen, stomach, Liver Channel.Function cures mainly: promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, gastral cavilty distension, dysentery is suffered from abdominal pain, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia.The effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving strengthens.For meat stagnation, dysentery is not well.

Rhizoma Zingiberis: pungent, hot.Return spleen, stomach, kidney, the heart, lung meridian.Function with cure mainly: Rhizoma Zingiberis warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant.For coldness and pain in the epigastrium, vomiting is had loose bowels, and cold extremities faint pulse, phlegm retention is breathed with cough.

Carapax Trionycis: salty, is slightly cold.Return liver, kidney channel.Function cures mainly: nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, brings down a fever except steaming.For fever due to yin deficiency, consumptive fever hectic fever due to YIN-deficiency, stirring-up of pathogenic wind in the interior resulting from deficiency, amenorrhea ， WEIJIA, chronic malaria malaria with splenomegaly.

Herba Hedyotidis Diffusae: sweet, light, cool.Enter stomach, large intestine, small intestine meridian.Function cures mainly: heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.For acute appendicitis (appendicitis), furuncle toxic swelling, jaundice due to damp-heat, the diseases such as dysuria; Furuncle carbuncle is controlled in external, venom.

The Rhizoma Atractylodis Macrocephalae: bitter, sweet, temperature.Return spleen, stomach warp.Function cures mainly: invigorating the spleen and benefiting QI, dampness diuretic, and hidroschesis is antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.

The invention has the beneficial effects as follows: the present invention with natural Chinese medicine for raw material, toxic and side effects is little, adopts and has heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, eliminating phlegm dredging collateral, hard masses softening and resolving, the herbal prescription of the functions such as strengthening the body resistance, Hepatoma therapy determined curative effect, toxicity is few, preparation method operation of the present invention is fairly simple, and fully can extract the effective ingredient in raw material of Chinese medicine, to reach better effect.Total effective rate is alleviated for 90% with traditional Chinese medicine composition for treating of the present invention.

Its beneficial effect is further illustrated below in conjunction with clinical data and model case.

One, clinical observation

1. clinical data: outpatient service and inpatient 160 groups, be divided into two groups at random, experimental group 80 example, age 46-78 year, 59 years old mean age; Matched group 80 example, age 42-77 year, 56 years old mean age.

2. diagnostic criteria: liver's lump; Abdominal part is vexed swollen, dyspepsia, Nausea and vomiting; Can there be persistence or intermittent pain in hepatic region; Weak, become thin, the heating of unknown cause and edema; Jaundice, ascites, skin pruritus.

3. Therapeutic Method: experimental group: take medicine of the present invention, water is swallowed, every day twice, each three, Time of Administration is determined according to the state of an illness weight feelings of patient, patients with mild 2 ~ 4 months, patient with severe symptoms about a year;

Matched group: take cinobufacin oral liquid, oral, 10 ~ 20ml(1 ~ 2), 3 times on the one.

4. efficacy assessment standard: 1. clinical recovery: above-mentioned hepatocarcinoma symptom complete incidence graph; 2. effective: hepatocarcinoma situation comparatively before obviously alleviate; 3. stablize: stable disease, without obvious corruptions; Extend patient vitals; 4. worsen: above-mentioned symptom worsens.

5. therapeutic outcome:

Experimental group: fully recover 39 people, cure rate 48.8%, effective 21 people, obvious effective rate 26.3%, stablizes 12 people, accounts for 15%, invalid 8 people, inefficiency 10%, total effective rate 90%.

Matched group: fully recover 21 people, cure rate 26.25%, effective 10 people, obvious effective rate 12.5%, stablizes 32 people, accounts for 40%, invalid 17 people, inefficiency 21.25%, total effective rate 78.75%.

The total effective rate taking medicine of the present invention is significantly better than the total effective rate that matched group takes cinobufacin oral liquid.

Two, model case:

Case 1, Lin, man, life in 1958.Check that take capsule of the present invention (every day twice, each three), after 4 months, patient can normally work and live for hepatocarcinoma, without uncomfortable or symptom March calendar year 2001.Review result display is normal.Patient dies from April, 2012, after treatment more than Ten Year Survival.

Case 2: Lee so-and-so, female, life in 1945.In January, 2004, examination in hospital was later period of hepatocarcinoma, right liver Huge mass, hepatalgia, took capsule of the present invention (every day twice, each four), and after treatment, minimal invasive treatment is normal, has slight symptom.Survive more than 7 years.

Case 3, Liu, man, life in 1964.In February, 2002, hospital diagnosis was later period of hepatocarcinoma, chronic viral hepatitis B, abdominal distention stomachache inappetence, weak, especially hepatalgia unbearably, and every day need inject dolantin, and in CT and color ultrasound examination liver, tumor is huge, and have multiple sub-stove, tumor tissues accounts for liver volume more than 70%, and liver cirrhosis is obvious, a small amount of ascites, a portal vein right side Tumor thrombus, hepatoma Metastasis.Take capsule of the present invention (every day twice, each four).Symptom progressively takes a turn for the better.After January, pain obviously alleviates, and without the need to injecting analgesic again, after three months, appetite improves, and abdominal distention alleviates, and spirit is comparatively treated front good, continues to take stable disease, and always without the need to using analgesic again, often two little bowls of meals eaten by meal, and life can be taken care of oneself.Existence more than 6 years after treatment.

Detailed description of the invention

Embodiment 1

Formula: Herba Artemisiae Scopariae 10g, Radix Scutellariae 6g, Cortex Mori 10g, Radix Glycyrrhizae 6g, Cutis Bufonis 5g, Radix Aucklandiae 4g, Rhizoma Curcumae 8g, Folium Ginkgo 11g, Radix Curcumae 9g, Resina Ferulae 8g, Semen Persicae 8g, Radix Patriniae heterophyllae 10g, Herba Sarcandrae 12g, Herba Lobeliae Chinensis 10g, Pericarpium Citri Reticulatae 9g, Herba Pileae Scriptae 10g, Radix Angelicae Sinensis 10g, Radix Astragali 20g, Fructus Crataegi 18g, Rhizoma Zingiberis 8g, Carapax Trionycis 15g, Herba Hedyotidis Diffusae 15g, Rhizoma Atractylodis Macrocephalae 10g.

Preparation method, comprises the following steps:

S1: prepare each raw material by above-mentioned weight;

S2: get ready Herba Artemisiae Scopariae, Radix Scutellariae, Cortex Mori, Cutis Bufonis, the Radix Aucklandiae, Rhizoma Curcumae, Folium Ginkgo, Radix Curcumae, Resina Ferulae, Semen Persicae, Radix Patriniae heterophyllae, Herba Sarcandrae, Herba Lobeliae Chinensis, Pericarpium Citri Reticulatae, Herba Pileae Scriptae, Radix Angelicae Sinensis, the Radix Astragali, Rhizoma Zingiberis, Carapax Trionycis, Herba Hedyotidis Diffusae and the Rhizoma Atractylodis Macrocephalae in the S1 step of half weight, put into marmite, add the soak by water 50min of 2.5 times, filter, obtain filtrate one, filtering residue puts back to marmite, adds 1.5 times of soak by water 30min, filter, obtain filtrate two; Merging filtrate one and filtrate two, distilling under reduced pressure, be concentrated into the thick paste that relative density is 1.19 ~ 1.38, then infrared drying, wears into fine powder, is medicated powder one;

S3: get ready Herba Artemisiae Scopariae, Radix Scutellariae, Cortex Mori, Cutis Bufonis, the Radix Aucklandiae, Rhizoma Curcumae, Folium Ginkgo, Radix Curcumae, Resina Ferulae, Semen Persicae, Radix Patriniae heterophyllae, Herba Sarcandrae, Herba Lobeliae Chinensis, Pericarpium Citri Reticulatae, Herba Pileae Scriptae, Radix Angelicae Sinensis, the Radix Astragali, Rhizoma Zingiberis, Carapax Trionycis, Herba Hedyotidis Diffusae and the Rhizoma Atractylodis Macrocephalae in the S1 step of second half weight, pulverize, then alcohol extraction is carried out with the ethanol of 45%, alcohol extract is carried out distilling under reduced pressure under 40 DEG C of conditions, be concentrated into the thick paste that relative density is 1.14 ~ 1.34, then infrared drying, wearing into fine powder, is medicated powder two;

S4: Fructus Crataegi ready in S1 step and Radix Glycyrrhizae are worn into fine powder, crosses 80 mesh sieves, obtains medicated powder three;

S5: by above-mentioned medicated powder one, medicated powder two, medicated powder three mix homogeneously, incapsulate, every capsules loads 0.4g.

Instructions of taking: every day twice, each 3 ~ 6.

Claims (2)

1. the medicine of a Hepatoma therapy, it is characterized in that, be made up of the raw material of following compositions and weight proportion: Herba Artemisiae Scopariae 10g, Radix Scutellariae 6g, Cortex Mori 10g, Radix Glycyrrhizae 6g, Cutis Bufonis 5g, Radix Aucklandiae 4g, Rhizoma Curcumae 8g, Folium Ginkgo 11g, Radix Curcumae 9g, Resina Ferulae 8g, Semen Persicae 8g, Radix Patriniae heterophyllae 10g, Herba Sarcandrae 12g, Herba Lobeliae Chinensis 10g, Pericarpium Citri Reticulatae 9g, Herba Pileae Scriptae 10g, Radix Angelicae Sinensis 10g, Radix Astragali 20g, Fructus Crataegi 18g, Rhizoma Zingiberis 8g, Carapax Trionycis 15g, Herba Hedyotidis Diffusae 15g, Rhizoma Atractylodis Macrocephalae 10g;

S1: prepare each raw material by above-mentioned weight;

S2: get ready Herba Artemisiae Scopariae, Radix Scutellariae, Cortex Mori, Cutis Bufonis, the Radix Aucklandiae, Rhizoma Curcumae, Folium Ginkgo, Radix Curcumae, Resina Ferulae, Semen Persicae, Radix Patriniae heterophyllae, Herba Sarcandrae, Herba Lobeliae Chinensis, Pericarpium Citri Reticulatae, Herba Pileae Scriptae, Radix Angelicae Sinensis, the Radix Astragali, Rhizoma Zingiberis, Carapax Trionycis, Herba Hedyotidis Diffusae and the Rhizoma Atractylodis Macrocephalae in the S1 step of half weight, put into marmite, add the soak by water 50min of 2.5 times, filter, obtain filtrate one, filtering residue puts back to marmite, adds 1.5 times of soak by water 30min, filter, obtain filtrate two; Merging filtrate one and filtrate two, distilling under reduced pressure, be concentrated into the thick paste that relative density is 1.19 ~ 1.38, then infrared drying, wears into fine powder, is medicated powder one;

S3: get ready Herba Artemisiae Scopariae, Radix Scutellariae, Cortex Mori, Cutis Bufonis, the Radix Aucklandiae, Rhizoma Curcumae, Folium Ginkgo, Radix Curcumae, Resina Ferulae, Semen Persicae, Radix Patriniae heterophyllae, Herba Sarcandrae, Herba Lobeliae Chinensis, Pericarpium Citri Reticulatae, Herba Pileae Scriptae, Radix Angelicae Sinensis, the Radix Astragali, Rhizoma Zingiberis, Carapax Trionycis, Herba Hedyotidis Diffusae and the Rhizoma Atractylodis Macrocephalae in the S1 step of second half weight, pulverize, then alcohol extraction is carried out with the ethanol of 45%, alcohol extract is carried out distilling under reduced pressure under 40 DEG C of conditions, be concentrated into the thick paste that relative density is 1.14 ~ 1.34, then infrared drying, wearing into fine powder, is medicated powder two;

S4: Fructus Crataegi ready in S1 step and Radix Glycyrrhizae are worn into fine powder, crosses 80 mesh sieves, obtains medicated powder three;

S5: by above-mentioned medicated powder one, medicated powder two, medicated powder three mix homogeneously, incapsulate, every capsules loads 0.4g.

2. the preparation method of the medicine of Hepatoma therapy according to claim 1, is characterized in that, comprises the following steps:

S1: prepare each raw material by above-mentioned weight;

S2: get ready Herba Artemisiae Scopariae, Radix Scutellariae, Cortex Mori, Cutis Bufonis, the Radix Aucklandiae, Rhizoma Curcumae, Folium Ginkgo, Radix Curcumae, Resina Ferulae, Semen Persicae, Radix Patriniae heterophyllae, Herba Sarcandrae, Herba Lobeliae Chinensis, Pericarpium Citri Reticulatae, Herba Pileae Scriptae, Radix Angelicae Sinensis, the Radix Astragali, Rhizoma Zingiberis, Carapax Trionycis, Herba Hedyotidis Diffusae and the Rhizoma Atractylodis Macrocephalae in the S1 step of half weight, put into marmite, add the soak by water 50min of 2.5 times, filter, obtain filtrate one, filtering residue puts back to marmite, adds 1.5 times of soak by water 30min, filter, obtain filtrate two; Merging filtrate one and filtrate two, distilling under reduced pressure, be concentrated into the thick paste that relative density is 1.19 ~ 1.38, then infrared drying, wears into fine powder, is medicated powder one;

S3: get ready Herba Artemisiae Scopariae, Radix Scutellariae, Cortex Mori, Cutis Bufonis, the Radix Aucklandiae, Rhizoma Curcumae, Folium Ginkgo, Radix Curcumae, Resina Ferulae, Semen Persicae, Radix Patriniae heterophyllae, Herba Sarcandrae, Herba Lobeliae Chinensis, Pericarpium Citri Reticulatae, Herba Pileae Scriptae, Radix Angelicae Sinensis, the Radix Astragali, Rhizoma Zingiberis, Carapax Trionycis, Herba Hedyotidis Diffusae and the Rhizoma Atractylodis Macrocephalae in the S1 step of second half weight, pulverize, then alcohol extraction is carried out with the ethanol of 45%, alcohol extract is carried out distilling under reduced pressure under 40 DEG C of conditions, be concentrated into the thick paste that relative density is 1.14 ~ 1.34, then infrared drying, wearing into fine powder, is medicated powder two;

S4: Fructus Crataegi ready in S1 step and Radix Glycyrrhizae are worn into fine powder, crosses 80 mesh sieves, obtains medicated powder three;

S5: by above-mentioned medicated powder one, medicated powder two, medicated powder three mix homogeneously, incapsulate, every capsules loads 0.4g.