CN104042894A - Medicine for treating optic atrophy and preparation method thereof - Google Patents
Medicine for treating optic atrophy and preparation method thereof Download PDFInfo
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- CN104042894A CN104042894A CN201410303448.0A CN201410303448A CN104042894A CN 104042894 A CN104042894 A CN 104042894A CN 201410303448 A CN201410303448 A CN 201410303448A CN 104042894 A CN104042894 A CN 104042894A
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Abstract
The invention discloses a medicine for treating optic atrophy and a preparation method thereof. The medicine is mainly prepared from feather cockscomb seed, fructus schizandrae, salviae miltiorrhizae, platycodon grandiflorum, atractylodes macrocephala koidz, barbary wolfberry fruit, mulberry and fructus aurantii in a certain weight ratio. The medicine has the functions of nourishing blood and tonifying the liver, clearing away heat and toxic materials, improving eyesight and engendering fluid, and is quick in effect taking and good in curative effect of treating the optic atrophy, and the cured optic atrophy does not relapse.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of optic atrophy and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Optic atrophy is not the title of a disease, and refer to that any disease causes retinal ganglial cells and its aixs cylinder generation pathological changes, cause a kind of formation that optic nerve all attenuates to change, generally betide retina to the Ganglion cell axon degeneration between lateral geniculate body.Optic atrophy is the final result of optic nerve disease damage, shows as degeneration and the disappearance of optic nerve fiber, and conduction function obstacle occurs that the visual field changes, and visual deterioration is also lost.Generally be divided into constitutional and Secondary cases two classes.Examination of ocular fundus is yellowish or pale asphyxia depending on nipple color as seen, and boundary is fuzzy, and physiological depression disappears, and blood vessel attenuates etc.At present, western medicine optic atrophy poor effect, and long-term taking Western medicine has more side effect, and therefore, there is great demand to the Chinese medicine of effective treatment optic atrophy in people.
Summary of the invention
The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the medicine of effective treatment optic atrophy, thereby has completed the present invention.
Object of the present invention is just to provide a kind of composition of medicine that can effectively treat optic atrophy.
Another object of the present invention has just been to provide the preparation method of this composition of medicine.
Medicine of the present invention is to select Semen Celosiae, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Radix Platycodonis, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Fructus Mori, Fructus Aurantii, Radix Ophiopogonis, Carapax et Plastrum Testudinis, Herba Equiseti Hiemalis, Semen sojae atricolor, Sorghum vulgare Pers. Wine, Asterias amurensis Lutken, Hepar Caprae seu ovis, Fel Gallus domesticus medicine combine, make each efficacy of drugs produce synergism these drug regimens, thus recurrence that can fast treating optic atrophy.Wherein select Semen Celosiae to be because its nature and flavor are bitter, cool, enter Liver Channel, the heat of dispeling the wind, the function of clearing away liver-fire, controls conjunctival congestion and swelling pain, hides from view, hypertension, epistaxis, skin wind heat pruritus, mange.Select Fructus Schisandrae Chinensis to be because its nature and flavor are sour, temperature, enters lung, kidney channel, astringes the lung, and nourishing kidney, promotes the production of body fluid, and receives antiperspirant, and the function of arresting seminal emission, controls the deficiency of the lung and breath with cough, and xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.Select Radix Salviae Miltiorrhizae to be because its nature and flavor are bitter, tepor, enters the heart, Liver Channel, has blood circulation and promoting silt, calming heart and tranquilizing mind, and evacuation of pus, the function of pain relieving, controls angina pectoris, menoxenia, dysmenorrhea, to close, metrorrhagia leukorrhagia ， mass in the abdomen, gathers, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.Select Radix Platycodonis to be because its nature and flavor toil is flat, enter lung, stomach warp, have out lung qi dispersing gas, the function of the evacuation of pus of eliminating the phlegm, controls exogenous cough, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache.Selecting the Rhizoma Atractylodis Macrocephalae is because its property bitter but sweet flavor, and temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizziness, spontaneous perspiration, nausea is uneasy.Select Fructus Lycii to be because its nature and flavor are sweet, flat, there is nourishing kidney, lung moistening, tonifying liver, the function of improving eyesight, controls hepatic and renal YIN deficiency, and soreness of the waist and knees is had a dizzy spell, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, seminal emission.Select Fructus Mori to be because its nature and flavor are sweet, cold, enter liver, kidney channel, there is tonifying liver, kidney tonifying, relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and grows the function of liquid, controls hepatic and renal YIN deficiency, quench one's thirst, constipation, order is dark, tinnitus, scrofula, articular instability.Select Fructus Aurantii to be because its nature and flavor toil, cool.Enter lung, spleen, large intestine channel.Dispelling the stagnated QI, row expectorant, removing food stagnancy.Control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.Select Radix Ophiopogonis to be because its property sweet and slightly bitter taste is cold, enter lung, stomach, heart channel, have nourishing YIN and moistening the lung, the relieving restlessness that clears away heart-fire, the function of reinforcing stomach reg fluid, controls dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung abscess, asthenia dysphoria with smothery sensation, thirsty clearly, calentura Tianjin wound, dry mouth and throat, constipation.Select Carapax et Plastrum Testudinis to be because its nature and flavor are salty sweet, flat, enter liver, kidney channel, there is YIN nourishing, YANG hyperactivity suppressing, the kidney invigorating, the function of strong bone, controls deficiency of kidney yin, hectic fever due to YIN-deficiency consumptive fever, spits blood, epistaxis, chronic cough, seminal emission, metrorrhagia, leukorrhagia, lumbago, the atrophic debility of bones, stirring of wind due to deficiency of YIN, chronic dysentery, chronic malaria, hemorrhoid, non-closure of fontanels jin infants.Select Herba Equiseti Hiemalis to be because its nature and flavor sweetness and bitterness is flat, enter lung, liver, gallbladder meridian, have wind-dispelling heat-dissipating, expelling pathogenic factors from muscles, the function of nebula removing, controls the raw nebula of order, epiphora induced by wind, discharging fresh blood stool, dysentery, proctoptosis, malaria, laryngalgia, carbuncle.Select Semen sojae atricolor to be because its nature and flavor are sweet, flat, enter spleen, kidney channel, invigorate blood circulation, diuretic, dispels the wind, the function of removing toxic substances, the swelling of harnessing the river is full, pathogenic wind-toxic beriberi, jaundice clonic spasm of the muscle, puerperal puerperal tetanus, locked mouth, carbuncle sore tumefacting virus; Separate poison of drug.Select wine to be because its nature and flavor sweetness and bitterness is pungent, temperature, poisonous, enter the heart, liver, lung, stomach warp, there is promoting blood circulation, resisting cold gas, the function of row medicine gesture, controls wind and cold arthralgia pain, and muscle arteries and veins contraction is anxious, the thoracic obstruction, trusted subordinate's cold type of pain.Select Asterias amurensis Lutken to be because its nature and flavor are salty, flat, attach to the lung and stomach meridians, there is detoxicating and resolving stagnation of pathogens, and the function of stomach and alleviating pain, control thyromegaly, scrofula, stomachache pantothenic acid, diarrhoea, otitis media.Select Hepar Caprae seu ovis to be because its nature and flavor sweetness and bitterness is cool, enter Liver Channel, useful blood, tonifying liver, the function of improving eyesight, controls blood deficiency and yellow complexion weakness and emaciation, and hepatasthenia dim eyesight is dim-sighted, and night blindness is hidden from view.Select Fel Gallus domesticus to be because its nature and flavor bitter cold has antiinflammatory, cough-relieving, eliminates the phlegm, removing toxic substances, and the function of improving eyesight, controls pertussis, chronic bronchitis, children's's bacillary dysentery, sand Stranguria, conjunctival congestion is shed tears, eczema after ear, hemorrhoid.
The drug dose of component of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Semen Celosiae 10-20 gram of Fructus Schisandrae Chinensis 15-25 gram of Radix Salviae Miltiorrhizae 15-25 gram
Radix Platycodonis 5-15 gram of Rhizoma Atractylodis Macrocephalae 10-20 gram of Fructus Lycii 15-25 gram
Fructus Mori 10-20 gram of Fructus Aurantii 10-20 gram of Radix Ophiopogonis 10-20 gram
Carapax et Plastrum Testudinis 5-15 gram of Herba Equiseti Hiemalis 5-15 gram of Semen sojae atricolor 10-20 gram
Sorghum vulgare Pers. Wine 790-810 gram of Asterias amurensis Lutken 15-25 gram of Hepar Caprae seu ovis 15-25 gram
Fel Gallus domesticus 15-25 gram.
Preferable amount is
20 grams of 20 grams of Radix Salviae Miltiorrhizaes of 15 grams of Fructus Schisandrae Chinensis of Semen Celosiae
20 grams of 15 grams of Fructus Lycii of 10 grams of Rhizoma Atractylodis Macrocephalaes of Radix Platycodonis
15 grams of 15 grams of Radix Ophiopogonis of 15 grams of Fructus Aurantiis of Fructus Mori
15 grams of 10 grams of Semen sojae atricolor of 10 grams of Herba Equiseties Hiemalis of Carapax et Plastrum Testudinis
20 grams of 20 grams of Hepar Caprae seu ovis of 800 grams of Asterias amurensis Lutkenes of Sorghum vulgare Pers. Wine
20 grams of Fel Gallus domesticus.
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Semen Celosiae: the 8-10 month gathers, extracts aerial parts or spica, rubs with the hands and removes seed, removes impurity, dries;
2, Fructus Schisandrae Chinensis: sieve dedust bits, remove impurity, to put in food steamer and steam thoroughly, taking-up is dried;
3, Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;
4, Radix Platycodonis: choose clean impurity, except removing LU, clean and pull out, run through rear section, dry;
5, the Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
6, Fructus Lycii: the clean impurity of winnowing with a dustpan, pluck residual stalk and the base of a fruit;
7, Fructus Mori: wash, choose decontamination, extract long handle, dry;
8, Fructus Aurantii: remove flesh, core, clean, slightly soak, pull out, soften, till pinching doubling with hands, section, dries;
9, Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, pump the heart after running through, then clean and dry;
10, Carapax et Plastrum Testudinis: soak with clear water, scrape off residual meat, clean, dry, knock fritter, smashs to pieces;
11, Herba Equiseti Hiemalis: clean, slightly profit, cuts off root, and cutting, dries;
12, Semen sojae atricolor: get crude drug, remove impurity, sieve removes chip, and the used time smashs to pieces;
13, wine: select high-quality Sorghum vulgare Pers. Wine;
14, Asterias amurensis Lutken: after seizure, fleshing, cleaning, drying;
15, Hepar Caprae seu ovis: clean, striping, fritters;
16, Fel Gallus domesticus: get freshly-slaughtered poultry gallbladder, clean.
Two, preparation
1, first the Asterias amurensis Lutken of described weight, Hepar Caprae seu ovis, Fel Gallus domesticus are put into Sorghum vulgare Pers. Wine and are soaked 3 days, then take out watt on dry and grind as fine powder.
2,, again by the Semen Celosiae of described weight, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Radix Platycodonis, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Fructus Mori, Fructus Aurantii, Radix Ophiopogonis, Carapax et Plastrum Testudinis, Herba Equiseti Hiemalis, Semen sojae atricolor medicine are put into Sorghum vulgare Pers. Wine slow fire and are boiled, until Sorghum vulgare Pers. Wine to the greatest extent after, by medical material watt on dry, grind as smalls.
3, the fine powder described Sorghum vulgare Pers. Wine being soaked and Sorghum vulgare Pers. Wine boil use up fine powder mixing and stirring, incapsulate and get final product.
Medicine of the present invention has the tonifying liver of nourishing blood, heat-clearing and toxic substances removing, and the effect that improving eyesight is promoted the production of body fluid, is used for the treatment of optic atrophy, short treating period, instant effect, has no side effect.
The specific embodiment
By test example, further set forth below the beneficial effect of medicine of the present invention, these test examples have comprised animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get 30 of rabbit, male and female dual-purpose, body weight 2.0-2.5kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 1.5 grams/kg, and normal amount is 0.75 gram/kg, and administering mode is administration by gavage administration, and every day, secondary, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The observations of [test example 2] Drug therapy optic atrophy of the present invention
1, physical data
Accept optic atrophy totally 33 examples for medical treatment.
2, diagnostic criteria
Clinical main manifestations visual deterioration and optic disc are canescence or pale.During optic disc peripheral nerve fibrous layer disease damage, can occur crack shape or wedge-shaped defect, the former becomes compared with black, for layer of retina,pigmentary exposes; It is more red that the latter is, for choroid exposes.If infringement betides lower edge district on optic disc, more easy to identify, Yin Gai district nerve fibre layer thickens especially, if disease damage, away from optic disc district, because these region nerve fibers are led attenuation, is difficult for finding.Optic disc around often points out nerve fibre layer to have pathological changes with focal atrophy, is due to nerve fibre layer Gai district's attenuation.
Although conventional ophthalmofundoscopy can find, with the more easily inspection of taking pictures without red smooth ophthalmoscope and optical fundus.The little blood vessel of optic disc is generally 9～10, if optic atrophy, these little number of blood vessel will reduce.With the visible arteria retina of fashion, attenuate with narrow, inaccessible.
3, Therapeutic Method
Select above-mentioned medicament, to patient, take, every day 2 times, each 8 grams, with heat wine, be taken after mixing with liquid, within 30 days, be a course for the treatment of, take continuously 2 courses for the treatment of.
4, efficacy assessment standard
Effective: the recovery from illness of optic atrophy symptom, observe half a year without bounce-back person;
Take a turn for the better: optic atrophy symptom is obviously improved, and body constitution progressively strengthens;
Invalid: optic atrophy symptom, without change, does not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy optic atrophy 33 examples of the present invention, effective 30 examples of result, obvious effective rate is 90.91%, 2 examples that take a turn for the better, and improvement rate is 6.06%, invalid 1 example, total effective rate is 96.97%.
Claims (3)
1. a medicine for the treatment of optic atrophy, is characterized in that: it is to be made by the crude drug in following weight range:
Semen Celosiae 10-20 gram of Fructus Schisandrae Chinensis 15-25 gram of Radix Salviae Miltiorrhizae 15-25 gram
Radix Platycodonis 5-15 gram of Rhizoma Atractylodis Macrocephalae 10-20 gram of Fructus Lycii 15-25 gram
Fructus Mori 10-20 gram of Fructus Aurantii 10-20 gram of Radix Ophiopogonis 10-20 gram
Carapax et Plastrum Testudinis 5-15 gram of Herba Equiseti Hiemalis 5-15 gram of Semen sojae atricolor 10-20 gram
Sorghum vulgare Pers. Wine 790-810 gram of Asterias amurensis Lutken 15-25 gram of Hepar Caprae seu ovis 15-25 gram
Fel Gallus domesticus 15-25 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
20 grams of 20 grams of Radix Salviae Miltiorrhizaes of 15 grams of Fructus Schisandrae Chinensis of Semen Celosiae
20 grams of 15 grams of Fructus Lycii of 10 grams of Rhizoma Atractylodis Macrocephalaes of Radix Platycodonis
15 grams of 15 grams of Radix Ophiopogonis of 15 grams of Fructus Aurantiis of Fructus Mori
15 grams of 10 grams of Semen sojae atricolor of 10 grams of Herba Equiseties Hiemalis of Carapax et Plastrum Testudinis
20 grams of 20 grams of Hepar Caprae seu ovis of 800 grams of Asterias amurensis Lutkenes of Sorghum vulgare Pers. Wine
20 grams of Fel Gallus domesticus.
3. according to the preparation method of medicine described in claim 1 or 2, it comprises the following steps:
(1) get the raw materials ready
(1) Semen Celosiae: the 8-10 month gathers, extracts aerial parts or spica, rubs with the hands and removes seed, removes impurity, dries;
(2) Fructus Schisandrae Chinensis: sieve dedust bits, remove impurity, to put in food steamer and steam thoroughly, taking-up is dried;
(3) Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;
(4) Radix Platycodonis: choose clean impurity, except removing LU, clean and pull out, run through rear section, dry;
(5) Rhizoma Atractylodis Macrocephalae: choose clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
(6) Fructus Lycii: the clean impurity of winnowing with a dustpan, pluck residual stalk and the base of a fruit;
(7) Fructus Mori: wash, choose decontamination, extract long handle, dry;
(8) Fructus Aurantii: remove flesh, core, clean, slightly soak, pull out, soften, till pinching doubling with hands, section, dries;
(9) Radix Ophiopogonis: choose clean impurity, be soaked in water, pull out, pump the heart after running through, then clean and dry;
(10) Carapax et Plastrum Testudinis: soak with clear water, scrape off residual meat, clean, dry, knock fritter, smashs to pieces;
(11) Herba Equiseti Hiemalis: clean, slightly profit, cuts off root, and cutting, dries;
(12) Semen sojae atricolor: get crude drug, remove impurity, sieve removes chip, and the used time smashs to pieces;
(13) wine: select high-quality Sorghum vulgare Pers. Wine;
(14) Asterias amurensis Lutken: after seizure, fleshing, cleaning, drying;
(15) Hepar Caprae seu ovis: clean, striping, fritters;
(16) Fel Gallus domesticus: get freshly-slaughtered poultry gallbladder, clean;
(2) preparation
(1) first the Asterias amurensis Lutken of described weight, Hepar Caprae seu ovis, Fel Gallus domesticus are put into Sorghum vulgare Pers. Wine and are soaked 3 days, then take out watt on dry and grind as fine powder;
(2) again by the Semen Celosiae of described weight, Fructus Schisandrae Chinensis, Radix Salviae Miltiorrhizae, Radix Platycodonis, the Rhizoma Atractylodis Macrocephalae, Fructus Lycii, Fructus Mori, Fructus Aurantii, Radix Ophiopogonis, Carapax et Plastrum Testudinis, Herba Equiseti Hiemalis, Semen sojae atricolor medicine are put into Sorghum vulgare Pers. Wine slow fire and are boiled, until Sorghum vulgare Pers. Wine to the greatest extent after, by medical material watt on dry, grind as smalls;
(3) fine powder described Sorghum vulgare Pers. Wine being soaked and Sorghum vulgare Pers. Wine boil use up fine powder mixing and stirring, incapsulate and get final product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106729438A (en) * | 2017-01-30 | 2017-05-31 | 防城港市奥氏蓝科技有限公司 | A kind of medicine of therapeutic community's property retinitis |
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| CN103623128A (en) * | 2013-12-12 | 2014-03-12 | 苏振华 | Medicine for treating optic atrophy and preparation method thereof |
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| CN103623128A (en) * | 2013-12-12 | 2014-03-12 | 苏振华 | Medicine for treating optic atrophy and preparation method thereof |
Non-Patent Citations (2)
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| 庞万敏，等: "复明丸治疗视神经萎缩26例", 《辽宁中医杂志》 * |
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| CN106729438A (en) * | 2017-01-30 | 2017-05-31 | 防城港市奥氏蓝科技有限公司 | A kind of medicine of therapeutic community's property retinitis |
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