CN103623128A

CN103623128A - Medicine for treating optic atrophy and preparation method thereof

Info

Publication number: CN103623128A
Application number: CN201310672825.3A
Authority: CN
Inventors: 苏振华
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-12-12
Filing date: 2013-12-12
Publication date: 2014-03-12
Anticipated expiration: 2033-12-12
Also published as: CN103623128B

Abstract

The invention discloses a medicine for treating optic atrophy and a preparation method thereof. The medicine is mainly prepared from medicines, namely, black soybean, bryozoatum, plastrum testudinis and the like according to a certain weight ratio. The medicine disclosed by the invention has the functions of enriching yin and nourishing kidney, activating blood and alleviating water retention, and dispelling the wind and detoxifying, and is rapid to take effect, good in curative effect and has no side effects when being used for treating optic atrophy.

Description

A kind of medicine for the treatment of optic atrophy and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of optic atrophy and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Optic atrophy refers to that optic nerve fiber generation degeneration and conduction function obstacle and all diseases of optic nerve lesion that causes all can cause optic atrophy.Be mainly visual deterioration, severe patient can be as blind as a bat, constriction of visual field or have central scotoma, and have dyschromatopsia.Primary optic atrophy, is pale asphyxia depending on nipple, and the aperture of its boundary and sieve plate is clear, and retinal vessel attenuates, and blood capillary disappears.Secondary optic atrophy, is canescence, wax yellow or pale red depending on nipple, and boundary is fuzzy, and physiological depression disappears, and sieve plate hole is unintelligible, and retinal vessel attenuates, and tremulous pulse is with white sheath sometimes.Because Western medicine cannot effectively be treated optic atrophy, and take Western medicine and have more side effect, expense is high, so people exist great demand to the Chinese medicine of rapid, effective treatment optic atrophy, up to now, does not also find about relevant report of the present invention.

Summary of the invention

The inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, has finally found the medicine of effective treatment optic atrophy, thereby has completed the present invention.

Object of the present invention is just to provide a kind of Chinese medicine composition of more effective treatment optic atrophy.

Another object of the present invention has just been to provide the preparation method of this Chinese medicine composition.

Medicine of the present invention is to select Semen sojae atricolor, Pumex, Carapax et Plastrum Testudinis, Magnetitum, Concha Margaritifera, Fructus Lycii medicine to combine preparation, makes each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat the recurrence of optic atrophy.Select Semen sojae atricolor to be because its nature and flavor are sweet, flat, enter spleen, kidney channel, invigorate blood circulation, diuretic, dispels the wind, the function of removing toxic substances, the swelling of harnessing the river is full, pathogenic wind-toxic beriberi, jaundice clonic spasm of the muscle, puerperal puerperal tetanus, locked mouth, carbuncle sore tumefacting virus; Separate poison of drug.Select Pumex to be because its nature and flavor are salty-cold, enter lung, stomach warp, have lung heat clearing fire, change old expectorant, softening the hard mass, treating stranguria function, controls expectorant dyspnea of heat type and coughs, old accumulation of phlegm piece, goiter, scrofula, hernia, skin ulcer is swollen, corneal nebula.Select Carapax et Plastrum Testudinis to be because its nature and flavor are salty sweet, flat, enter liver, kidney channel, there is YIN nourishing, YANG hyperactivity suppressing, the kidney invigorating, the function of strong bone, controls deficiency of kidney yin, hectic fever due to YIN-deficiency consumptive fever, spits blood, epistaxis, chronic cough, seminal emission, metrorrhagia, leukorrhagia, lumbago, the atrophic debility of bones, stirring of wind due to deficiency of YIN, chronic dysentery, chronic malaria, hemorrhoid, non-closure of fontanels jin infants.Select Magnetitum to be because its nature and flavor are pungent salty, flat, enter kidney, liver, lung meridian, there is calming down the floating YANG to promote inspiration for relieving dyspnea, the function of tranquillizing the mind by relieving convulsion, controls the vertigo, Hiccough and deaf, dyspnea due to deficiency ， Jing Epilepsy, palpitation with a distress feeling.Select Concha Margaritifera to be because its nature and flavor are salty, cool, enter the heart, liver two warps, have suppressing the hyperactive liver, YANG hyperactivity suppressing, arresting convulsion, the function of hemostasis, controls dizziness, tinnitus, cardiopalmus, insomnia, demented ， Jing Epilepsy, spits blood, epistaxis, metrorrhagia.Select Fructus Lycii to be because its nature and flavor are sweet, flat, there is nourishing kidney, lung moistening, tonifying liver, the function of improving eyesight, controls hepatic and renal YIN deficiency, and soreness of the waist and knees is had a dizzy spell, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, and loses clear.

The specific embodiment

The drug dose of component of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight

Semen sojae atricolor 15-25 gram of Pumex 15-25 gram of Carapax et Plastrum Testudinis 10-20 gram

Magnetitum 10-20 gram of Concha Margaritifera 15-25 gram of Fructus Lycii 10-20 gram

Be preferably

15 grams of 20 grams of Carapax et Plastrum Testudinis of 20 grams of Pumexs of Semen sojae atricolor

15 grams of 20 grams of Fructus Lycii of 15 grams of Concha Margaritiferas of Magnetitum

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Semen sojae atricolor: choose clean impurity, dry;

2, Pumex: clean, dry, smash;

3, Carapax et Plastrum Testudinis: soak with clear water, scrape off residual meat, clean, dry knock fritter;

4, Magnetitum: choose decontamination, smash, sieve;

5, Concha Margaritifera: choose decontamination, knock fragment, sieve dedust bits;

6, Fructus Lycii: the clean impurity of winnowing with a dustpan, pluck residual stalk and the base of a fruit.

Two, preparation

1, the Semen sojae atricolor of described weight, Pumex, Carapax et Plastrum Testudinis, Magnetitum, Concha Margaritifera, Fructus Lycii are put into 2000 grams of Chinese liquor and added a cover that slow fire is stewing to be boiled 30 minutes.

2, well-done said medicine is placed in to watt upper slow fire and dries, then pulverize respectively, be ground into smalls.

3, the smalls of grinding is incapsulated and be get final product.

Medicine of the present invention has the function of YIN nourishing, the kidney invigorating, improving eyesight, is used for the treatment of optic atrophy instant effect, good effect.

By test example, further set forth below the beneficial effect of medicine of the present invention, these tests comprise animal toxicity test and the clinical observation on the therapeutic effect test of medicine of the present invention.

The animal toxicity test of [test example 1] medicine of the present invention

Get 30 of West Germany rabbits, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, 15 every group, wherein one group is overdose test group, another group is normal amount test group, with distilled water, be mixed with suspension for West Germany's rabbit test, overdose test group is 25ml/kg, and dosage is 0.4 gram/kg, normal amount is 10ml/kg, dosage is 0.2 gram/kg, and administering mode is administration by gavage administration, every day secondary, serve on 7 days, observe administration reaction every day, result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's totally 100 examples for medical treatment.

2, diagnostic criteria

Optic atrophy is the final result of optic nerve disease damage.Show as degeneration and the disappearance of optic nerve fiber, conduction function obstacle, occurs that the visual field changes, and visual deterioration is also lost.Generally be divided into constitutional and Secondary cases two classes, except above-mentioned symptom, examination of ocular fundus is still yellowish or pale asphyxia depending on nipple color as seen, and boundary is fuzzy, and physiological depression disappears, and blood vessel attenuates etc.

3, Therapeutic Method

Select above-mentioned medicament, to patient's bath, take, each 10 grams, be a course for the treatment of at twice, 15 day every day, takes continuously three courses for the treatment of.

4, efficacy assessment standard

Effective: optic atrophy symptom is almost recovered, remaining nerve fiber is recovered normal function;

Take a turn for the better: optic atrophy symptom alleviates, and the state of an illness progressively takes a turn for the better;

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form):

Figure 2013106728253100002DEST_PATH_IMAGE001

In above-mentioned treatment, by Drug therapy optic atrophy 100 examples of the present invention, effective 86 examples of result, obvious effective rate is 86%, 4 examples that take a turn for the better, and improvement rate is 4%, invalid 10 examples, total effective rate is 90%.

Claims

1. a medicine for the treatment of optic atrophy, is characterized in that: it is to be made by the crude drug in following weight range:

Magnetitum 10-20 gram of Concha Margaritifera 15-25 gram of Fructus Lycii 10-20 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

15 grams of 20 grams of Fructus Lycii of 15 grams of Concha Margaritiferas of Magnetitum.

3. according to the preparation method of medicine described in claim 1 or 2, it is characterized in that: it comprises the following steps:

(1) get the raw materials ready

(1) Semen sojae atricolor: choose clean impurity, dry;

(2) Pumex: clean, dry, smash;

(3) Carapax et Plastrum Testudinis: soak with clear water, scrape off residual meat, clean, dry knock fritter;

(4) Magnetitum: choose decontamination, smash, sieve;

(5) Concha Margaritifera: choose decontamination, knock fragment, sieve dedust bits;

(6) Fructus Lycii: the clean impurity of winnowing with a dustpan, pluck residual stalk and the base of a fruit;

(2) preparation

(1) Semen sojae atricolor of described weight, Pumex, Carapax et Plastrum Testudinis, Magnetitum, Concha Margaritifera, Fructus Lycii are put into 2000 grams of Chinese liquor and added a cover that slow fire is stewing to be boiled 30 minutes;

(2) well-done said medicine is placed in to watt upper slow fire and dries, then pulverize respectively, be ground into smalls;

(3) smalls of grinding is incapsulated and be get final product.