CN106890263A

CN106890263A - It is a kind of to treat medicine of tinnitus and preparation method thereof

Info

Publication number: CN106890263A
Application number: CN201710125777.4A
Authority: CN
Inventors: 牛健坤
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-03-05
Filing date: 2017-03-05
Publication date: 2017-06-27

Abstract

Medicine of tinnitus and preparation method thereof is treated the invention discloses a kind of, its be by the fruit of Chinese wolfberry, honeysuckle, chrysanthemum, play both sides of the street, the tuber of dwarf lilyturf, the root of herbaceous peony, almond, lily, plantain seed, radix scrophulariae, grass-leaved sweetflag, the achene of Siberian cocklebur, polygala, dogwood fruit, rheum officinale, the capsule of weeping forsythia etc. are prepared from according to a certain weight ratio, medicine of the present invention has clearing heat and detoxicating, slit phlegm qi-regulating, dissipates wind clearing damp, tonifying liver, nourshing kidney, the function of moistening lung, for treating tinnitus instant effect, good effect, does not recur.

Description

It is a kind of to treat medicine of tinnitus and preparation method thereof

Technical field

Medicine of tinnitus and preparation method thereof is treated the present invention relates to a kind of, belongs to the field of Chinese medicines.

Technical background

Tinnitus is the result of many disease different pathologicals change for involving auditory system, and the cause of disease is complicated, and mechanism is unclear, mainly Show as without corresponding external world's sound source or electro photoluminescence, and subjective have sound perception in Er Nei or encephalic.The traditional Chinese medical science then thinks tinnitus Attacked with wind-heat, disturbing upward of liver-fire, the turbid upper heap soil or fertilizer over and around the roots of phlegm, kidney deficiency and liver is weakness of the spleen and the stomach relevant.Because western medicine side effect is big, therefore There is great demand in people, to the Chinese medicine of effectively treatment tinnitus up to now, it has not been found that having on of the invention Close report.

The content of the invention

The present inventor have found effectively treatment tinnitus finally according to the checking repeatedly of research and the clinical test of theory of traditional Chinese medical science Medicine, so as to complete the present invention.

It is an object of the invention to provide a kind of Chinese medicine composition of effective treatment tinnitus.

Another object of the present invention just there is provided the preparation method of the Chinese medicine composition.

Medicine of the present invention be selection the fruit of Chinese wolfberry, honeysuckle, chrysanthemum, play both sides of the street, the tuber of dwarf lilyturf, the root of herbaceous peony, almond, lily, plantain seed, Radix scrophulariae, grass-leaved sweetflag, the achene of Siberian cocklebur, polygala, dogwood fruit, rheum officinale, the capsule of weeping forsythia, radix bupleuri, the root of large-flowered skullcap, the fruit of glossy privet are combined preparation, by this A little drug regimens cause that each efficacy of drugs produces synergy such that it is able to effectively treat tinnitus.Wherein from the fruit of Chinese wolfberry be because For its nature and flavor is sweet, put down, there is nourshing kidney, moistening lung, tonifying liver, the function of improving eyesight controls liver-kidney Yin deficiency, and soreness and weakness of waist and knees is had a dizzy spell, and blurred vision is more Tear, cough due to consumptive disease is quenched one's thirst, and loses clear.From honeysuckle because its nature and flavor is sweet, tremble with fear, enter lung, stomach, there is heat-clearing, the work(of removing toxic substances Can, control warm disease heating, toxic-heat and blood stasis, large carbuncle, pyogenic infections, scrofula, anal fistula.From chrysanthemum because its nature and flavor sweetness and bitterness, cool, enter lung, Liver Channel, there is dispelling wind, and disappear heat, improving eyesight, the function of removing toxic substances, controls headache, dizziness, hot eyes, ambition dysphoria with smothery sensation, furunculosis, pyogenic infections.From road road It is logical because its is bitter in taste flat, pass through 12 warps, there is dispelling wind and removing obstruction in the meridians, and the function of promoting urination and removing dampness controls oedema, turgor, Amenorrhea, breast It is few, brothers' contraction.From the tuber of dwarf lilyturf because its property sweet and slightly bitter taste, trembles with fear, enter lung, stomach, the heart channel of Hang-Shaoyin, there is Yin nourishing and lung moistening, relieving restlessness that clears away heart-fire, benefit The function that stomach promotes the production of body fluid, controls dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung carbuncle, consumptive disease dysphoria with smothery sensation, clear thirsty, pyreticosis Tianjin wound, dry throat, Constipation.From the root of herbaceous peony because its nature and flavor picric acid, cool, enter liver, the spleen channel have nourishing blood and liver, analgesic in delaying, and hold back the cloudy work(for receiving sweat Can, control chest and abdomen pain over the hypochondriac region, diarrhea dysentery abdominal pain, spontaneous sweating, fever due to yin deficiency, irregular menstruation, uterine bleeding, under band.From almond be because For its is bitter in taste, temperature is poisonous, enters lung, large intestine channel, there is expelling phlegm and arresting coughing, relievings asthma, and the function of ease constipation controls exogenous cough, breathes heavily full, larynx Numbness, dry constipation of intestines.From lily because its property sweet and slightly bitter taste, puts down, enter the heart, lung channel, moisten the lung and relieve the cough, the work(of clearing away the heart fire and tranquillizing Can, control tuberculosis and cough long, saliva phlegm blood is coughed, waste heat is not clear after pyreticosis, dysphoria palpitates with fear, wandering, beriberi edema.It is from plantain seed Because its nature and flavor is sweet, tremble with fear, enter kidney, bladder warp, favourable water, heat-clearing, improving eyesight, the function of eliminating the phlegm controls urinary obstruction, stranguria with turbid discharge, under band, Hematuria, summer-heat and damp rush down dysentery, cough ant phlegm, arthritis with fixed pain caused by dampness, hot eyes is hidden from view.It is salty from radix scrophulariae because its is bitter in taste, it is cool, enter lung, kidney channel, There is enriching yin, fall fire, relieving restlessness, the function of removing toxic substances controls pyreticosis polydipsia, send out spot, hectic fever due to yin labor heat, night sleeps not peaceful, and spontaneous sweating, Tianjin is hindered just It is secret, hematemesis and epistaxis, abscess of throat, carbuncle swells, scrofula.From grass-leaved sweetflag because its nature and flavor is pungent, tepor.Enter the heart, liver, the spleen channel.Have one's ideas straightened out, Slit phlegm, qi-regulating, promoting blood circulation dissipates wind, dries.Epilepsy is controlled, coma due to blocking of the respiratory system, pyreticosis god is wrong, and forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, abdomen Bitterly, wind-cold-dampness arthralgia, swollen ulcer drug, traumatic injury.From the achene of Siberian cocklebur because its nature and flavor is sweet, temperature is poisonous, enters lung, Liver Channel, there is scattered Wind, analgesic, clearing damp, the function of desinsection controls anemofrigid headache, nasosinusitis, dentalgia, wind-cold-dampness arthralgia, four pin contractions bitterly, scabies leprosy, itch.From Polygala has tranquilize the mind and promote the intelligence because its nature and flavor toil, temperature, enter the heart, kidney channel, and eliminating the phlegm, the function of Xie Yu controls palpitation with fear, forgetful, dream Lose, insomnia, cough ant phlegm, ulcer sore swells.From dogwood fruit because its nature and flavor is sour, tepor has filling liver kidney, the work(of puckery vital essence Can, impotence is controlled, to pass out semen, liver cold of insufficiency type heat, the heart shakes arteries and veins and dissipates.From rheum officinale because its is bitter in taste, cold, enter stomach, large intestine, liver footpath, have Purge heat poison, breaks stagnant, and the function of row hemostasis controls real heat constipation, and delirious speech is gone mad, dyspepsia feeling of fullness, and dysentery is from the beginning of tenesmus, the stasis of blood Menopause Bi , lumps in the chest and abdomen, when the hot epidemic disease of row, sudden and violent swelling ophthalmalgia spits blood, and bleeding from five sense organs or subcutaneous tissue, yang jaundice, oedema, stranguria with turbid discharge urinates red, large carbuncle pyogenic infections, malignant boil Sore, burn.It is cool from the capsule of weeping forsythia because its is bitter in taste, enter the heart, liver, gallbladder channel, there is heat-clearing, detoxify, dissipating bind, the function of detumescence, Control warm, erysipelas, macula, large carbuncle pyogenic infections, scrofula, urine leaching closes.It is cool from radix bupleuri because its is bitter in taste, enter liver, gallbladder channel, Have with inducing diaphoresis, soothing the liver, the function of rising Yang controls fevers and chills alternate, and fullness in the chest and hypochondriac pain, bitter taste is deaf, headache and dizziness, malaria, and lower profit is de- Anus, irregular menstruation, metroptosis.From the root of large-flowered skullcap because its is bitter in taste, tremble with fear, enter the heart, lung, courage, large intestine channel, have and rush down excess fire, remove Damp and hot, hemostasis, antiabortive function controls high fever polydipsia, and cough with lung heat, damp-heat dysentery, jaundice, heat gonorrhea is told, is defeated in battle, collapses, is leaked, hot eyes Swell and ache, fetal irritability, carbuncle swells furunculosis.From the fruit of glossy privet because its nature and flavor bitter sweet, puts down, enter liver and kidney channel, there is filling liver kidney, strong waist The function of knee, controls yin asthenia generating intrinsic heat, dizzy, mesh flower tinnitus, soreness and weakness of waist and knees, poliosis.

Specific embodiment

The drug dose of instant component is also that inventor summarizes what is drawn by largely groping, and the consumption of each component is following heavy All there is preferable curative effect in the range of amount：

10-20 grams of the fruit of Chinese wolfberry, 10-20 grams of honeysuckle, 15-25 grams of chrysanthemum plays both sides of the street 10-20 grams, 5-15 grams of the tuber of dwarf lilyturf, root of herbaceous peony 10- 15 grams, 10-20 grams of almond, 15-20 grams of lily, 10-20 grams of plantain seed, 5-15 grams of radix scrophulariae, 10-15 grams of grass-leaved sweetflag, achene of Siberian cocklebur 10- 20 grams, 7-12 grams of polygala, 10-20 grams of dogwood fruit, 5-15 grams of rheum officinale, 10-20 grams of the capsule of weeping forsythia, 10-15 grams of radix bupleuri, 10-15 grams of the root of large-flowered skullcap, 15-25 grams of the fruit of glossy privet.

Preferably：

15 grams of the fruit of Chinese wolfberry, 15 grams of honeysuckle, 20 grams of chrysanthemum plays both sides of the street 15 grams, 10 grams of the tuber of dwarf lilyturf, 12 grams of the root of herbaceous peony, 15 grams of almond, lily 18 grams, 15 grams of plantain seed, 10 grams of radix scrophulariae, 12 grams of grass-leaved sweetflag, 15 grams of the achene of Siberian cocklebur, 9 grams of polygala, 15 grams of dogwood fruit, 10 grams of rheum officinale, even Stick up 15 grams, 12 grams of radix bupleuri, 12 grams of the root of large-flowered skullcap, 20 grams of the fruit of glossy privet.

The preparation method of medicine of the present invention is as follows

First, get the raw materials ready

1st, the fruit of Chinese wolfberry：Winnow with a dustpan net impurity, pluck the stalk and the base of a fruit of residual；

2nd, honeysuckle：Silt is weeded out, net impurity is picked；

3rd, chrysanthemum：Pick net leaf stalk, anthocaulus and spare impurity；

4th, play both sides of the street：Impurity is removed, is cleaned, dried；

5th, the tuber of dwarf lilyturf：Net impurity is picked, is soaked in water, pulled out, pump the heart after running through, then cleaned and dry；

6th, the root of herbaceous peony：Impurity is picked, size is separated, is soaked in water to eighty per cant thoroughly, pulled out, solarization is dried in the air, profit is uniform to inside and outside humidity, cuts Piece, dries；

7th, almond：Net impurity is picked, is put and slightly boil in boiling water, pulled out when crust microcreping, in leaching cold water, slough kind of a skin, dried, winnowed with a dustpan Only；

8th, lily：Pick impurity, black valve, ash disposal of winnowing with a dustpan bits；

9th, plantain seed：Impurity is picked, spare, empty grain is weeded out；

10th, radix scrophulariae：Net impurity is picked, except removing LU, is cleaned and is run through, cut into slices, dried；

11st, grass-leaved sweetflag：Impurity is picked, is cleaned, soaked slightly, run through, cut into slices, dried；

12nd, the achene of Siberian cocklebur：Most impurity is picked, deburring weeds out grey bits, and micro- stir-fry to yellow, taking-up is cooled；

13rd, polygala：Impurity is picked, segment weeds out grey bits；

14th, dogwood fruit：Clean, except removal core and impurity, dry；；

15th, rheum officinale：Net impurity is picked, size stepping, vexed profit is uniform to inside and outside humidity, cuts into slices or is cut into small pieces, dries；

16th, the capsule of weeping forsythia：Net impurity is picked, stranding is opened, except discarding stalk；

17th, radix bupleuri：Impurity is picked, residual stem is removed, silt is cleaned, pulled out, section in time, dries immediately after running through；

18th, the root of large-flowered skullcap：Impurity is picked, residual stem is removed, slightly leaching is pulled out in infiltrating or putting boiling water with cold water, and section is dried after running through（Note Meaning avoids exposure excessively rubescent）；

19 fruit of glossy privets：Impurity is picked, is cleaned, dried.

2nd, prepare

1st, by the fruit of Chinese wolfberry of the weight, honeysuckle, chrysanthemum, play both sides of the street, the tuber of dwarf lilyturf, the root of herbaceous peony, almond, lily, plantain seed, radix scrophulariae, Grass-leaved sweetflag, the achene of Siberian cocklebur, polygala, dogwood fruit, rheum officinale, the capsule of weeping forsythia, radix bupleuri, the root of large-flowered skullcap, the fruit of glossy privet are put into decocting container, are added water for the first time 6 times of amounts, after soaking 100 minutes, fry by intense fire to boil and rise, then with being cooked by slow fire 20 minutes, first time decoction liquor is filtered to obtain, by first Secondary decoction liquor is poured into container；

2nd, the dregs of a decoction of filtering are added water 4 times and is measured, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second decoction liquor；

3rd, will decoction liquor mixing and stirring twice, be divided into 2 doses and take.

Grass-leaved sweetflag has and has one's ideas straightened out in prescription, slit phlegm, qi-regulating, promoting blood circulation, dissipates wind, and the function of drying is monarch drug in a prescription；Honeysuckle heat-clearing, solution Poison；Polygala tranquilize the mind and promote the intelligence, eliminating the phlegm, Xie Yu, the two is ministerial drug, and three taste medicines are played jointly has one's ideas straightened out, and slit phlegm, qi-regulating dissipates wind, dries, Heat-clearing, the effect of removing toxic substances, treatment tinnitus effect comprehensively, and with clearing heat and detoxicating, slit phlegm qi-regulating, can effect a permanent cure based on scattered wind clearing damp, Chinese holly Qi has a nourshing kidney, moistening lung, tonifying liver, and the function of improving eyesight is adjutant, and the fruit of glossy privet has the function of filling liver kidney to make medicine, and all medicines are to control with being left Mark.

Medicine of the present invention has clearing heat and detoxicating, slit phlegm qi-regulating, dissipates wind clearing damp, tonifying liver, nourshing kidney, the function of moistening lung, for controlling Treat tinnitus, short treating period, instant effect, non-relapse after healing.

The beneficial effect of medicine of the present invention is expanded on further below by way of test example, these test examples include this hair The animal toxicity test report of bright medicine and clinical observation on the therapeutic effect data.

The animal toxicity test report of [test example 1] medicine of the present invention：

Rabbit 30 is taken, male and female dual-purpose, 2.0-2.5kg of body weight is divided to two groups, and every group 15, one of which is tested for overdose Group, another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is given for administration by gavage Medicine, twice daily, takes medicine continuously 7 days, the reaction of observation administration daily, as a result shows that two groups of rabbit activities, diet are normal, and medicine is without bad Toxic and side effect.

The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention

1st, physical data

Accept tinnitus out-patient totally 17 for medical treatment.

2nd, diagnostic criteria

Classical symptom is Hearing, can be with " buzz ", and some patients also can be with otalgia, and long-term tinnitus can cause patient Produce agitation, anxiety, anxiety, fear or depression mood.

3rd, treatment method

From above-mentioned medicament, taken to patient, each take 1 dose, early daily, evening respectively takes 1 time, be within 15 days a course for the treatment of, continuously Take 2 courses for the treatment of.

4th, efficacy assessment standard

It is effective：Tinnitus symptom disappears, and recovers normal, recovery from illness；

Take a turn for the better：Patient's Hearing, the symptom that abnormal sound occurs in the sense of hearing is clearly better, and hearing is progressively recovered；

It is invalid：Improvement standard person is not reached.

5th, treatment results（See the table below）

In above-mentioned treatment, with drug therapy tinnitus patient of the present invention 17, as a result effective 14, obvious effective rate is 82.35%, good Turn 2, improvement rate is 11.77%, and invalid 1, total effective rate is 94.12%.

Claims

1. a kind of medicine for treating tinnitus, it is characterised in that：It is made up of the bulk drug in following weight range：

2. medicine according to claim 1, wherein the consumption of each bulk drug is：

3. the preparation method of medicine according to claim 1 or claim 2, it comprises the following steps：

（One）Get the raw materials ready

（1）The fruit of Chinese wolfberry：Winnow with a dustpan net impurity, pluck the stalk and the base of a fruit of residual；

（2）Honeysuckle：Silt is weeded out, net impurity is picked；

（3）Chrysanthemum：Pick net leaf stalk, anthocaulus and spare impurity；

（4）Play both sides of the street：Impurity is removed, is cleaned, dried；

（5）The tuber of dwarf lilyturf：Net impurity is picked, is soaked in water, pulled out, pump the heart after running through, then cleaned and dry；

（6）The root of herbaceous peony：Impurity is picked, size is separated, is soaked in water to eighty per cant thoroughly, pulled out, solarization is dried in the air, profit is uniform to inside and outside humidity, Section, dries；

（7）Almond：Net impurity is picked, is put and slightly boil in boiling water, pulled out when crust microcreping, in leaching cold water, slough kind of a skin, dried, winnowed with a dustpan Only；

（8）Lily：Pick impurity, black valve, ash disposal of winnowing with a dustpan bits；

（9）Plantain seed：Impurity is picked, spare, empty grain is weeded out；

（10）Radix scrophulariae：Net impurity is picked, except removing LU, is cleaned and is run through, cut into slices, dried；

（11）Grass-leaved sweetflag：Impurity is picked, is cleaned, soaked slightly, run through, cut into slices, dried；

（12）The achene of Siberian cocklebur：Most impurity is picked, deburring weeds out grey bits, and micro- stir-fry to yellow, taking-up is cooled；

（13）Polygala：Impurity is picked, segment weeds out grey bits；

（14）Dogwood fruit：Clean, except removal core and impurity, dry；；

（15）Rheum officinale：Net impurity is picked, size stepping, vexed profit is uniform to inside and outside humidity, cuts into slices or is cut into small pieces, dries；

（16）The capsule of weeping forsythia：Net impurity is picked, stranding is opened, except discarding stalk；

（17）Radix bupleuri：Impurity is picked, residual stem is removed, silt is cleaned, pulled out, section in time, dries immediately after running through；

（18）The root of large-flowered skullcap：Impurity is picked, residual stem is removed, slightly leaching is pulled out in infiltrating or putting boiling water with cold water, and section is dried after running through, and is noted Meaning avoids exposure excessively rubescent；

（19）The fruit of glossy privet：Impurity is picked, is cleaned, dried；

（Two）Prepare

（1）By the fruit of Chinese wolfberry of the weight, honeysuckle, chrysanthemum, play both sides of the street, the tuber of dwarf lilyturf, the root of herbaceous peony, almond, lily, plantain seed, radix scrophulariae, Grass-leaved sweetflag, the achene of Siberian cocklebur, polygala, dogwood fruit, rheum officinale, the capsule of weeping forsythia, radix bupleuri, the root of large-flowered skullcap, the fruit of glossy privet are put into decocting container, are added water 6 times and are measured, After immersion 100 minutes, fry by intense fire to boil and rise, then with being cooked by slow fire 20 minutes, filter to obtain first time decoction liquor, first time is decocted Liquid is poured into container；

（2）The dregs of a decoction of filtering are added water 4 times and is measured, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second decoction liquor；

（3）Decoction liquor mixing and stirring twice is incited somebody to action, is divided into 2 doses and is taken.