CN106924694A

CN106924694A - It is a kind of to treat medicine of habitual constipation and preparation method thereof

Info

Publication number: CN106924694A
Application number: CN201710151898.6A
Authority: CN
Inventors: 张玲
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-03-15
Filing date: 2017-03-15
Publication date: 2017-07-07

Abstract

Medicine of habitual constipation and preparation method thereof is treated the invention discloses a kind of, it is prepared from according to a certain weight ratio by radix scrophulariae, the tuber of dwarf lilyturf, radix rehmanniae recen, brush-cherry seed, fructus cannabis, Fructus Aurantii, radix polygonati officinalis, the wind-weed, fructus amomi, Radix Glycyrrhizae, the fleece-flower root, dried orange peel, the root of three-nerved spicebush, the shell of areca nut, radix bupleuri, rheum officinale, ginger, the seed of Oriental arborvitae, the Radix Astragali, monkshood, Radix Angelicae Sinensis, peach kernel, medicine of the present invention has moisturize laxation, lower gas Li Shui, treating stranguria promoting blood circulation, nourishing Yin and falling fire, the function of mental-tranquilization, for treating habitual constipation's instant effect, good effect, do not recur.

Description

It is a kind of to treat medicine of habitual constipation and preparation method thereof

Technical field

Medicine of habitual constipation and preparation method thereof is treated the present invention relates to a kind of, belongs to the field of Chinese medicines.

Background technology

Habitual constipation refers to long-term, chronic functional constipation, is mainly in the elderly.But also there is scholar to think habitual Constipation is not limited only to functional consitipation, and it includes colonic constipation and proctogenous constipation again, therefore, with habitual constipation People's symptomatic treatment the reason for should early go to hospital to find out constipation.Because western medicine side effect is big, therefore people are to effectively controlling There is great demand in the Chinese medicine for treating habitual constipation, up to now, it has not been found that on relevant report of the invention.

The content of the invention

The present inventor have found effectively treatment custom finally according to the checking repeatedly of research and the clinical test of theory of traditional Chinese medical science The medicine of property constipation, so as to complete the present invention.

It is an object of the invention to provide a kind of Chinese medicine composition of effective treatment habitual constipation.

Another object of the present invention just there is provided the preparation method of the Chinese medicine composition.

Medicine of the present invention is the selection radix scrophulariae, tuber of dwarf lilyturf, radix rehmanniae recen, brush-cherry seed, fructus cannabis, Fructus Aurantii, radix polygonati officinalis, the wind-weed, fructus amomi, sweet Grass, the fleece-flower root, dried orange peel, the root of three-nerved spicebush, the shell of areca nut, radix bupleuri, rheum officinale, ginger, the seed of Oriental arborvitae, the Radix Astragali, monkshood, Radix Angelicae Sinensis, peach kernel are combined Prepare, these drug regimens are caused that each efficacy of drugs produces synergy such that it is able to effectively treat habitual constipation.Its Middle selection radix scrophulariae is salty because its is bitter in taste, cool, enters lung, kidney channel, there is enriching yin, and fall fire, relieving restlessness, the function of removing toxic substances is controlled pyreticosis and is tired of Yearningly, spot, hectic fever due to yin labor heat are sent out, night sleeps not peaceful, spontaneous sweating, Tianjin hinder constipation, hematemesis and epistaxis, abscess of throat, carbuncle swells, scrofula.From The tuber of dwarf lilyturf because its property sweet and slightly bitter taste, is trembled with fear, and enters lung, stomach, the heart channel of Hang-Shaoyin, there is Yin nourishing and lung moistening, and relieving restlessness that clears away heart-fire, the function of reinforcing stomach reg fluid is controlled Dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung carbuncle, consumptive disease dysphoria with smothery sensation, clear thirsty, pyreticosis Tianjin wound, dry throat, constipation.From radix rehmanniae recen Because its nature and flavor is sweet, tremble with fear, the thoughts of returning home, liver and kidney channel have clearing heat and cooling blood, and yin-nourishing, the function of promoting the production of body fluid controls pyreticosis polydipsia, in the deficiency of Yin Heat, hectic fever due to yin labor heat, Heat Diabetes is spitted blood, bleeding from five sense organs or subcutaneous tissue, spot dermexanthesis.From brush-cherry seed because its nature and flavor work hard it is sweet, put down, enter spleen, Intestine and small intestine is passed through, and is had and is moisturized, and laxation, lower gas, the function of Li Shui controls qi stagnation of large intestine, dry puckery obstructed, difficult urination, extensive abdominal edema, four Limb edema, tinea pedis.From fructus cannabis because its nature and flavor is sweet, put down, enter spleen, stomach, large intestine channel, have and moisturize, laxation is treating stranguria, promoting blood circulation Function, control dry constipation of intestines, quench one's thirst, heat gonorrhea, wandering arthritis, dysentery, irregular menstruation, scabies, tinea is insane.From Fructus Aurantii because its nature and flavor Toil, it is cool, enter lung, spleen, large intestine channel, there is a relieving stagnant Qi, row phlegm, the function of disperse accumulations, it is stagnant to control chest diaphragm phlegm, the feeling of stuffiness in chest, coerces swollen, dyspepsia, gas, Vomit inverse, weight, prolapse of the anus, the prolapse of uterus after diarrhea.From radix polygonati officinalis because its nature and flavor is sweet, put down, enter lung, stomach has yin-nourishing, moisturizes, Relieving restlessness, the function of quenching the thirst controls pyreticosis sun wound, and cough, polydipsia, deficient fever, the paddy that disappears is easily hungry, frequent urination.From the wind-weed be because For its is bitter in taste, tremble with fear, enter lung, stomach, kidney channel, there is nourishing Yin and falling fire, the function of moisturize laxation is controlled dysphoria with smothery sensation and quenched one's thirst, hectic fever due to yin labor heat, lung heat Cough, dry feces, difficult urination.From fructus amomi because its nature and flavor is pungent, temperature, enter spleen, stomach, have promoting the circulation of qi adjust in, and stomach, wake up The function of spleen, controls stomachache ruffian is swollen, and loss of appetite food stagnation, choke is cold to rush down cold dysentery, pregnant movement of the foetus every vomiting.From Radix Glycyrrhizae because its nature and flavor Gan Ping, enters spleen, stomach, lung channel, has and processs, deficiency of food, abdomen weakness of the spleen and the stomach with controlling with middle emergency, moistening lung, removing toxic substances, the function of coordinating the drug actions of a prescription Pain loose stool, overstrain heating, consumptive lung disease cough, palpitaition shies carbuncle, and raw with abscess of throat is controlled, peptic ulcer, ulcer sores, antidote is malicious And food poisoning.From the fleece-flower root because its nature and flavor bitter sweet is puckery, tepor enters liver and kidney channel, there is tonifying liver, kidney-nourishing, blood-nourishing, wind-dispelling Function, control liver-kidney Yin deficiency, hair must be early white, and the deficiency of blood is dizzy, and waist and knee is weak, and muscles and bones is ached, and passes out semen, and collapses band, chronic malaria, protracted dysentery, slowly Property hepatitis, carbuncle swells, scrofula, intestines wind, haemorrhoids.From dried orange peel because its is bitter in taste, pungent, temperature, return lung, the spleen channel have regulating qi-flowing for strengthening spleen, Eliminating dampness and eliminating phlegm function, controls chest gastral cavity turgor, and deficiency of food is vomited and diarrhoea, coughing with a lot of sputum.From the root of three-nerved spicebush because its nature and flavor is pungent, temperature, enter spleen, Lung, kidney, bladder warp, there is pleasant, open strongly fragrant, cold dispelling, the function of analgesic, control circulation of vital energy in the wrong direction chest and abdomen swelling and pain, and place food is discontented, and food is told in gastric disorder causing nausea, trembles with fear Hernia, tinea pedis, frequent urination.From the shell of areca nut because its nature and flavor is pungent, tepor enters spleen, stomach, intestine and small intestine warp, in having lower gas wide, OK The function of water, controls gastral cavity abdomen ruffian is swollen, tinea pedis, oedema.It is cool from radix bupleuri because its is bitter in taste, enter liver, gallbladder channel, have with inducing diaphoresis, Soothing the liver, the function of rising Yang controls fevers and chills alternate, and fullness in the chest and hypochondriac pain, bitter taste is deaf, headache and dizziness, malaria, lower sharp prolapse of the anus, irregular menstruation, Metroptosis.From rheum officinale because its is bitter in taste, cold, enter stomach, large intestine, liver footpath, there is the poison that purges heat, break stagnant, the work(of row hemostasis Can, control real heat constipation, delirious speech is gone mad, dyspepsia feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menopause Bi , lumps in the chest and abdomen, when the hot epidemic disease of row, Sudden and violent swelling ophthalmalgia, is spitted blood, and bleeding from five sense organs or subcutaneous tissue, yang jaundice, oedema, stranguria with turbid discharge is urinated red, large carbuncle pyogenic infections, furunculosis, burn.From ginger because its Nature and flavor are pungent, temperature, enter lung, stomach, the spleen channel, deliver, cold dispelling, preventing or arresting vomiting, open the function of phlegm, and cure cold chill, and vomiting, phlegm and retained fluid is breathed with cough, Turgor, diarrhea, the solution tuber of pinellia, rhizoma arisaematis and ichthyophagy crab, birds and beasts meat poisoning.From the seed of Oriental arborvitae because its nature and flavor is sweet, put down, enter the heart, liver, spleen Through, there is mental-tranquilization, the function of relaxing bowel controls palpitation with fear, insomnia, seminal emission, night sweat, the function of constipation.From the Radix Astragali because Its nature and flavor is sweet, tepor, enters lung, the spleen channel, raw to defend solid table with beneficial, inducing diuresis for removing edema, eliminating toxic, the function of myogenic, controls spontaneous perspiration, night sweat, Blood-arthralgia, edema, ulcer is not burst or is burst and holds back long；Process with the function of having tonifying middle-Jiao and Qi, control internal injury overstrain, splenasthenic diarrhea, prolapse of the anus, the deficiency of vital energy Blood takes off, and collapses band and the disease of all laboured breathing deficiency of blood.It is poisonous from monkshood because its property acrid-sweet flavor, warm, enter the heart, spleen, kidney channel, have Return sun and mend fire, the function of dispelling cold and removing dampness controls yin excess network sun, and loss of YANG due to profuse perspiration is told profit and fainted inverse, trusted subordinate's crymodynia, Spleen diarrhea cold dysentery, beriberi liquor Swollen, children shy slowly, wind-cold-dampness arthralgia , Wei lame contractions, the disease of cloudy subcutaneous ulcer sore leakage and all chronic diseaseses.From Radix Angelicae Sinensis because its nature and flavor Sweet, acrid, warm, enters the heart, liver, the spleen channel, there is benefiting blood and regulating blood circulation, and menstruction regulating and pain relieving, the function of moisturize laxation controls irregular menstruation, and Amenorrhea is suffered from abdominal pain, Disorder lumps in the abdomen knot gathers, uterine bleeding, headache due to deficiency of blood, dizziness, Impotence numbness, and intestinal dryness is difficult just, weight, ulcer sores, metal-inflicted wound, injury from falling down after dysentery characterized by blood in the stool.Choosing With peach kernel because its nature and flavor bitter sweet, puts down, enter the heart, liver, large intestine channel, there is the blood-breaking row stasis of blood, moisturize the function of sliding warp, controlling through closing, Disorder Lump in the abdomen, pyreticosis stores blood, blood-arthralgia, malaria, traumatic injury, blood stasis and swelling pain, the dry constipation of blood.

Specific embodiment

The drug dose of instant component is also that inventor summarizes what is drawn by largely groping, and the consumption of each component is following heavy All there is preferable curative effect in the range of amount：

10-14 grams of radix scrophulariae, 10-14 grams of the tuber of dwarf lilyturf, 10-14 grams of radix rehmanniae recen, 4-8 grams of brush-cherry seed, 4-8 grams of fructus cannabis, 4-8 grams of Fructus Aurantii, 10-14 grams of radix polygonati officinalis, 5-10 grams of the wind-weed, 5-10 grams of fructus amomi, 3-5 grams of Radix Glycyrrhizae, 10-20 grams of the fleece-flower root, 5-15 grams of dried orange peel, root of three-nerved spicebush 5-15 Gram, 10-20 grams of the shell of areca nut, 5-15 grams of radix bupleuri, 5-15 grams of rheum officinale, 5-10 grams of ginger, 5-15 grams of the seed of Oriental arborvitae, 10-20 grams of the Radix Astragali is attached Sub- 4-8 grams, 5-15 grams of Radix Angelicae Sinensis, 5-15 grams of peach kernel.

Preferably：

12 grams of radix scrophulariae, 12 grams of the tuber of dwarf lilyturf, 12 grams of radix rehmanniae recen, 6 grams of brush-cherry seed, 6 grams of fructus cannabis, 6 grams of Fructus Aurantii, 12 grams of radix polygonati officinalis, the wind-weed 5 Gram, 5 grams of fructus amomi, 3 grams of Radix Glycyrrhizae, 15 grams of the fleece-flower root, 10 grams of dried orange peel, 10 grams of the root of three-nerved spicebush, 15 grams of the shell of areca nut, 10 grams of radix bupleuri, 10 grams of rheum officinale, 5 grams of ginger, 10 grams of the seed of Oriental arborvitae, 15 grams of the Radix Astragali, 6 grams of monkshood, 10 grams of Radix Angelicae Sinensis, 10 grams of peach kernel.

The preparation method of medicine of the present invention is as follows

First, get the raw materials ready

1st, radix scrophulariae：Net impurity is picked, except removing LU, is cleaned and is run through, cut into slices, dried；

2nd, the tuber of dwarf lilyturf：Net impurity is picked, is soaked in water, pulled out, pump the heart after running through, then cleaned and dry；

3rd, radix rehmanniae recen：Crude drug is taken, impurity is removed, cleaned, slightly moistened, cut sheet, dried, weed out chip；

4th, brush-cherry seed：Spare is weeded out, washes in a pan net, pick net impurity and broken shell, dried, the used time smashs to pieces；

5th, fructus cannabis：Impurity and residual shell are picked, net benevolence is taken；

6th, Fructus Aurantii：Flesh, core are removed, edulcoration slightly soaks, pulls out, softens, pinching doubling with hand, section is dried；

7th, radix polygonati officinalis：Impurity is removed, soil is cleaned, vexed profit is uniform to inside and outside humidity, and section is dried；

8th, the wind-weed：Net impurity is picked, is hit with water and washed, pulled out, softened, section is dried；

9th, fructus amomi：Impurity and shell are picked, is smashed to pieces；

10th, Radix Glycyrrhizae：Pick impurity, clean, be soaked in water to eighty per cant it is saturating when, pull out, run through, cut into slices, dry；

11st, the fleece-flower root：Impurity is picked, is cleaned, pulled out with bubble to eighty per cant thoroughly, profit is uniform to inside and outside humidity, cuts into slices or the side of being cut into Block, dries；

12nd, dried orange peel：Crude drug is taken, the pericarp of impurity and blackening is removed, wash quickly is net, softens, chopping, dries or low temperature drying, Weed out grey bits；

13rd, the root of three-nerved spicebush：Impurity is picked, size bar is separated, is noted changing water according to season with bubble thoroughly, prevent smelly, pulled out cut in time Piece, weeds out grey bits；

14th, the shell of areca nut：Pick net impurity, rolloff makes soft, beats, and weeds out spare；

15th, radix bupleuri：Impurity is picked, residual stem is removed, silt is cleaned, pulled out, section in time, dries immediately after running through；

16th, rheum officinale：Net impurity is picked, size stepping, vexed profit is uniform to inside and outside humidity, cuts into slices or is cut into small pieces, dries；

17th, ginger：Impurity is picked, soil, used time section is cleaned；

18th, the seed of Oriental arborvitae：Net impurity is picked, the shell of residual is removed and is planted skin；

19th, the Radix Astragali：Net impurity is picked, the root head and hollow larger root of residual is removed, is soaked in water, pulled out, cut in time after running through Piece, dries；

20th, monkshood：It is soaked in water, pulls out, cut into slices, dries；

21st, Radix Angelicae Sinensis：Impurity is picked, is cleaned, vexed profit is slightly dried in the air, and section is dried；

22nd, peach kernel：Remove duricrust impurity, put boiling water pot in boil to crust microcreping, pull out, immersion cold water in, stranding remove kind of a skin, shine It is dry, winnow with a dustpan net.

2nd, prepare

1st, by the radix scrophulariae of the weight, the tuber of dwarf lilyturf, radix rehmanniae recen, brush-cherry seed, fructus cannabis, Fructus Aurantii, radix polygonati officinalis, the wind-weed, fructus amomi, Radix Glycyrrhizae, what The tuber of multiflower knotweed, dried orange peel, the root of three-nerved spicebush, the shell of areca nut, radix bupleuri, rheum officinale, ginger, the seed of Oriental arborvitae, the Radix Astragali, monkshood, Radix Angelicae Sinensis, peach kernel are put into decocting container It is interior, add water 6 times and measure, after soaking 100 minutes, fry by intense fire to boil and rise, then with being cooked by slow fire 20 minutes, filter to obtain decoction for the first time Liquid, first time decoction liquor is poured into container；

2nd, the dregs of a decoction of filtering are added water 5 times and is measured, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second decoction liquor；

3rd, will decoction liquor mixing and stirring twice, be divided into 2 doses and take.

Brush-cherry seed has moisturize laxation in prescription, and the function of lower gas Li Shui is monarch drug in a prescription；Fructus cannabis has moisturize laxation, treating stranguria promoting blood circulation Function；The wind-weed has a nourishing Yin and falling fire, the function of moisturize laxation, and the two is ministerial drug, and three taste medicines play moisturize laxation, lower gas profit jointly Water, treating stranguria promoting blood circulation, the effect of nourishing Yin and falling fire, treatment habitual constipation effect is comprehensive, and with moisturize laxation, lower gas Li Shui, enriching yin Can be effected a permanent cure based on fall fire, during the shell of areca nut has lower gas wide, the function of water-filling is adjutant, and the seed of Oriental arborvitae has mental-tranquilization, relaxes bowel To make medicine, all medicines are to take stopgap measures to function with being left.

Medicine of the present invention has moisturize laxation, and lower gas Li Shui, treating stranguria promoting blood circulation, nourishing Yin and falling fire, the function of mental-tranquilization is used for Treatment habitual constipation, short treating period, instant effect, non-relapse after healing.

The beneficial effect of medicine of the present invention is expanded on further below by way of test example, these test examples include this hair The animal toxicity test report of bright medicine and clinical observation on the therapeutic effect data.

The animal toxicity test report of [test example 1] medicine of the present invention：

Rabbit 30 is taken, male and female dual-purpose, 2.0-2.5kg of body weight is divided to two groups, and every group 15, one of which is tested for overdose Group, another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is given for administration by gavage Medicine, twice daily, takes medicine continuously 7 days, the reaction of observation administration daily, as a result shows that two groups of rabbit activities, diet are normal, and medicine is without bad Toxic and side effect.

The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention

1st, physical data

Accept habitual constipation out-patient totally 56 for medical treatment.

2nd, diagnostic criteria

Classical symptom is weekly that defecation is less than 3 times, or defecation often feels like difficulty.The people of constipation, can not only be detained because of stool And make toxin absorption excessive, also absorb excessive cholesterol than normal person because stool discharge is slow.Therefore, prolonged constipation People, complexion dusk is dim, too fat to move, shows a kind of abnormal ill face.

3rd, treatment method

From above-mentioned medicament, taken to patient, each take 1 dose, early daily, evening respectively takes 1 time, be within 7 days a course for the treatment of, continuous clothes With 3 courses for the treatment of.

4th, efficacy assessment standard

It is effective：Habitual constipation's symptom disappears, and recovers normal, recovery from illness；

Take a turn for the better：Habitual constipation's symptom is clearly better, and defecation frequency and time progressively recover normal；

It is invalid：Improvement standard person is not reached.

5th, treatment results（See the table below）

In above-mentioned treatment, with drug therapy habitual constipation patient of the present invention 56, as a result effective 47, obvious effective rate is 83.9%, take a turn for the better 6, improvement rate is 10.7%, and invalid 3, total effective rate is 94.6%.

Claims

1. a kind of medicine for treating habitual constipation, it is characterised in that：It is made up of the bulk drug in following weight range：

2. medicine according to claim 1, wherein the consumption of each bulk drug is：

3. the preparation method of medicine according to claim 1 or claim 2, it comprises the following steps：

（One）Get the raw materials ready

（1）Radix scrophulariae：Net impurity is picked, except removing LU, is cleaned and is run through, cut into slices, dried；

（2）The tuber of dwarf lilyturf：Net impurity is picked, is soaked in water, pulled out, pump the heart after running through, then cleaned and dry；

（3）Radix rehmanniae recen：Crude drug is taken, impurity is removed, cleaned, slightly moistened, cut sheet, dried, weed out chip；

（4）Brush-cherry seed：Spare is weeded out, washes in a pan net, pick net impurity and broken shell, dried, the used time smashs to pieces；

（5）Fructus cannabis：Impurity and residual shell are picked, net benevolence is taken；

（6）Fructus Aurantii：Flesh, core are removed, edulcoration slightly soaks, pulls out, softens, pinching doubling with hand, section is dried；

（7）Radix polygonati officinalis：Impurity is removed, soil is cleaned, vexed profit is uniform to inside and outside humidity, and section is dried；

（8）The wind-weed：Net impurity is picked, is hit with water and washed, pulled out, softened, section is dried；

（9）Fructus amomi：Impurity and shell are picked, is smashed to pieces；

（10）Radix Glycyrrhizae：Pick impurity, clean, be soaked in water to eighty per cant it is saturating when, pull out, run through, cut into slices, dry；

（11）The fleece-flower root：Impurity is picked, is cleaned, pulled out with bubble to eighty per cant thoroughly, profit is uniform to inside and outside humidity, cuts into slices or is cut into Square, dries；

（12）Dried orange peel：Crude drug is taken, the pericarp of impurity and blackening is removed, wash quickly is net, softens, chopping, dries or low temperature drying, Weed out grey bits；

（13）The root of three-nerved spicebush：Impurity is picked, size bar is separated, is noted changing water according to season with bubble thoroughly, prevent smelly, pulled out in time Section, weeds out grey bits；

（14）The shell of areca nut：Pick net impurity, rolloff makes soft, beats, and weeds out spare；

（15）Radix bupleuri：Impurity is picked, residual stem is removed, silt is cleaned, pulled out, section in time, dries immediately after running through；

（16）Rheum officinale：Net impurity is picked, size stepping, vexed profit is uniform to inside and outside humidity, cuts into slices or is cut into small pieces, dries；

（17）Ginger：Impurity is picked, soil, used time section is cleaned；

（18）The seed of Oriental arborvitae：Net impurity is picked, the shell of residual is removed and is planted skin；

（19）The Radix Astragali：Net impurity is picked, the root head and hollow larger root of residual is removed, is soaked in water, pulled out, cut in time after running through Piece, dries；

（20）Monkshood：It is soaked in water, pulls out, cut into slices, dries；

（21）Radix Angelicae Sinensis：Impurity is picked, is cleaned, vexed profit is slightly dried in the air, and section is dried；

（22）Peach kernel：Remove duricrust impurity, put boiling water pot in boil to crust microcreping, pull out, immersion cold water in, stranding remove kind of a skin, shine It is dry, winnow with a dustpan net；

（Two）Prepare

（1）By the radix scrophulariae of the weight, the tuber of dwarf lilyturf, radix rehmanniae recen, brush-cherry seed, fructus cannabis, Fructus Aurantii, radix polygonati officinalis, the wind-weed, fructus amomi, Radix Glycyrrhizae, what The tuber of multiflower knotweed, dried orange peel, the root of three-nerved spicebush, the shell of areca nut, radix bupleuri, rheum officinale, ginger, the seed of Oriental arborvitae, the Radix Astragali, monkshood, Radix Angelicae Sinensis, peach kernel are put into decocting container It is interior, add water 6 times and measure, after soaking 100 minutes, fry by intense fire to boil and rise, then with being cooked by slow fire 20 minutes, filter to obtain decoction for the first time Liquid, first time decoction liquor is poured into container；

（2）The dregs of a decoction of filtering are added water 5 times and is measured, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second decoction liquor；

（3）Decoction liquor mixing and stirring twice is incited somebody to action, is divided into 2 doses and is taken.