Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment ascariasis of biliary tract, thus completes the present invention.
Object of the present invention is just to provide a kind of composition of medicine effectively can treating ascariasis of biliary tract.
Another object of the present invention just there is provided the preparation method of this composition of medicine.
Medicine of the present invention selects Semen Arecae, Cortex Magnoliae Officinalis, Fructus Quisqualis, Pericarpium Zanthoxyli, Pericarpium Arecae, Endothelium Corneum Gigeriae Galli, Radix Codonopsis, Herba Lysimachiae, Fructus Jujubae, Rhizoma Zingiberis, Radix Et Rhizoma Rhei, Herba Taraxaci, Herba Pogostemonis, Rhizoma Osmundae, Concha Ostreae, Herba Asari, Folium Sennae, Cortex Meliae, the Rhizoma Pinelliae, Fructus Mume, Alumen, Semen Torreyae medicine to combine, each efficacy of drugs is made by these drug regimens to produce synergism, thus can the recurrence of fast treating ascariasis of biliary tract.Wherein select Semen Arecae to be because its nature and flavor toil, temperature, enters spleen, stomach, large intestine channel, has parasite killing, removing mass, the therapeutic method to keep the adverse QI flowing downwards, the function of row water, control malnutrition due to parasitic infestation, dyspepsia, abdominal distention, and heavy after dysentery, malaria, edema, beriberi, accumulation of phlegm in the hypochondrium ， Disorder ties.Select Cortex Magnoliae Officinalis to be because its nature and flavor toil, temperature, enter spleen, stomach, large intestine channel, have warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, dampness, the function of expectorant, control breast abdomen feeling of fullness distending pain, regurgitation, vomiting, dyspepsia does not disappear, and phlegm retention is breathed with cough, cold-damp dysentery.Select Fructus Quisqualis to be because its nature and flavor are sweet, temperature, poisonous, enter spleen, stomach warp, have parasite killing, removing food stagnancy, the function of spleen invigorating, control ascarid stomachache, infantile malnutrition, breast food is stagnated, abdominal distention, dysentery.Pericarpium Zanthoxyli is selected to be because its nature and flavor are pungent, temperature, poisonous, enter spleen, lung, kidney channel, have warming spleen and stomach for dispelling cold, dehumidifying, pain relieving, parasite killing, separate fish raw meat poison, control food stagnation and stop drink, trusted subordinate's cold type of pain, vomiting, oh, cough with dyspnea, anemofrigid-damp arthralgia, has loose bowels, dysentery, colic, toothache, ascariasis, enterobiasis, pudendal pruritus, skin ulcer scabies.Pericarpium Arecae is selected to be that tepor, enters spleen, stomach, intestine and small intestine warp, have therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, the function of row water, controls gastral cavity abdomen painful abdominal mass swollen, beriberi, edema because its nature and flavor are pungent.Select Endothelium Corneum Gigeriae Galli to be because its nature and flavor are sweet, flat, enter spleen, stomach warp, have removing food stagnancy stagnant, the function of strengthening the spleen and stomach, control food stagnation distension, vomiting regurgitation, dysentery, infantile malnutrition, quenches one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha.Select Radix Codonopsis to be because its nature and flavor are sweet, flat, start with, meridian of Foot-TAI YIN edema caused by disorder of QI, have invigorating the spleen and replenishing QI, the function of promoting the production of body fluid, controls weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, and lack of appetite is thirsty, chronic diarrhea, proctoptosis.Herba Lysimachiae is selected to be because its nature and flavor toil, cool, there is heat clearing away, diuresis, antitussive, detumescence, the function of removing toxic substances, subcutaneous ulcer of harnessing the Yellow River, edema, vesical calculus, malaria, lung abscess, cough, spit blood, stranguria with turbid discharge, leukorrhagia, rheumatic arthralgia, infantile malnutrition ， Jing Epilepsy, carbuncle, skin ulcer tinea, eczema.Select Fructus Jujubae to be that temperature, enters spleen, stomach warp, have spleen reinforcing stomach function regulating, supplementing QI for promoting the production of body fluid because its nature and flavor are sweet, adjust battalion to defend, separate the function of poison of drug, control insufficiency of stomach lack of appetite, the weak loose stool of spleen, qi-blood-body fluid is not enough, disharmony of nutrient QI with defensive QI, severe palpitation, woman hysteria.Select Rhizoma Zingiberis to be that heat, enters spleen, stomach, lung meridian because its nature and flavor are pungent, have warming middle-JIAO by cold, the function that recuperating depleted YANG is promoted blood circulation, controls trusted subordinate's cold type of pain, vomits and diarrhoea, cold extremities faint pulse, and cold fluid-retention is breathed with cough, anemofrigid-damp arthralgia, and yang deficiency is told, be defeated in battle, hematochezia.Radix Et Rhizoma Rhei is selected to be that enter stomach, large intestine, liver footpath, have the poison that purges heat, removing mass is stagnant because its nature and flavor are bitter, cold, the function of clots absorbing blood, control excess-heat constipation, delirium is gone mad, food stagnation feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menolipsis Bi ， lumps in the chest and abdomen, time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia, spits blood, epistaxis, YANG jaundice, edema, stranguria with turbid discharge, urinates red, carbuncle and ulcer toxic swelling, furuncle, burn.Select Herba Taraxaci to be because its property bitter but sweet flavor, cold, enter liver, stomach warp, have heat-clearing and toxic substances removing, the function of diuresis eliminating stagnation, controls acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.Herba Pogostemonis is selected to be that tepor, enters lung, spleen, stomach warp, have fast gas because its nature and flavor are pungent, and in, ward off dirty, the function of damp eliminating, cure cold heat-damp in summer, cold and heat, and headache, breast gastral cavity painful abdominal mass is vexed, and vomiting is had loose bowels, malaria, dysentery, halitosis.Select Rhizoma Osmundae to be because its nature and flavor are bitter, cool, enter liver, stomach warp, kill ascarid, silk ribbon, pinworm, heat clearing away, removing toxic substances, removing heat from blood, the function of hemostasis, controls anemopyretic cold, damp and hot skin eruption, spits blood, epistaxis, discharging fresh blood stool, dysentery, metrorrhagia, leukorrhagia.Select Concha Ostreae to be because its nature and flavor are salty and bitter, cool, enter liver, kidney channel, have yin fluid astringing, YANG hyperactivity suppressing, hidroschesis, arresting seminal emission, reduce phlegm, the function of softening the hard mass, Zhi Jing Epilepsy, dizzy, spontaneous perspiration, night sweat, seminal emission, stranguria with turbid discharge, metrorrhagia, leukorrhagia, scrofula, goiter.Select Herba Asari to be that temperature, enters lung, kidney channel, dispel the wind, cold expelling, row water because its nature and flavor are pungent, open the function of stealing, control air-cooled headache, nasal sinusitis, pain relieving, phlegm retention cough with dyspnea, rheumatic arthralgia.Folium Sennae is selected to be because its nature and flavor sweetness and bitterness, cold, enter large intestine channel, have the function of the intestinal stasis relieving that purges heat, control constipation with heat retention, stagnant abdominal distention.Cortex Meliae is selected to be that cold, poisonous, have heat clearing away, dampness, the function of parasite killing, controls ascarid, pinworm, rubella, scabies because its nature and flavor are bitter.Select the Rhizoma Pinelliae to be because its nature and flavor are pungent, temperature, poisonous, enter spleen, stomach warp, have drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the function of dissolving lump and resolving mass, control damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm is had a headache, dizzy sleeplessness, outer subduing inflammation.Fructus Mume is selected to be that temperature, enter liver, spleen, lung, large intestine channel, have convergence to promote the production of body fluid, the function of relieving colic caused by ascaris anthelmintic, controls chronic cough, deficiency-heat excessive thirst, chronic malaria, and dysentery, has blood in stool, hematuria, metrorrhagia, and the ascariasis of biliary tract is suffered from abdominal pain, vomiting, ancylostomiasis, psoriasis, bulbar conjunctiva polyp because its nature and flavor acid.Alumen is selected to be because its nature and flavor are sour and astringent, cold, poisonous, enter lung, spleen, stomach, large intestine channel, there is expectorant, dampness, antidiarrheal, removing toxic substances, the function of parasite killing, Zhi epilepsy, sore throat, sputum is stopped up very, hepatitis, jaundice, general edema with yellowish skin, taste-blindness rate, uterine prolapse, leucorrhea, dysentery, epistaxis, aphtha of the mouth and tongue, skin ulcer hemorrhoid scabies, water, fire, insect bite.Semen Torreyae is selected to be that flat, enter lung, stomach, large intestine channel, have parasite killing, removing food stagnancy, the function of moisturizing, controls abdominal pain due to worm stagnation, infantile malnutrition, cough caused by dryness, constipation, hemorrhoid because its nature and flavor are sweet.
Detailed description of the invention
The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Semen Arecae 15-25 gram Cortex Magnoliae Officinalis 10-20 gram Fructus Quisqualis 15-25 gram
Pericarpium Zanthoxyli 5-15 gram of Pericarpium Arecae 10-20 gram of Endothelium Corneum Gigeriae Galli 10-20 gram
Radix Codonopsis 15-25 gram of Herba Lysimachiae 5-15 gram of Fructus Jujubae 15-25 gram
Rhizoma Zingiberis 15-25 gram of Radix Et Rhizoma Rhei 10-20 gram of Herba Taraxaci 15-25 gram
Herba Pogostemonis 5-15 gram Rhizoma Osmundae 5-15 gram Concha Ostreae 15-25 gram
Herba Asari 15-25 gram of Folium Sennae 10-20 gram of Cortex Meliae 3-9 gram
Rhizoma Pinelliae 5-15 gram of Fructus Mume 5-15 gram of Alumen 15-25 gram
Semen Torreyae 25-35 gram
Preferable amount is
Semen Arecae 20 grams of Cortex Magnoliae Officinalis 15 grams of Fructus Quisqualis 20 grams
Pericarpium Zanthoxyli 10 grams of Pericarpium Arecae 15 grams of Endothelium Corneum Gigeriae Galli 15 grams
20 grams, Radix Codonopsis 20 grams of Herba Lysimachiaes 10 grams of Fructus Jujubaes
Rhizoma Zingiberis 20 grams of Radix Et Rhizoma Rhei 15 grams of Herba Taraxacis 20 grams
Herba Pogostemonis 10 grams of Rhizoma Osmundae 10 grams of Concha Ostreaes 20 grams
Herba Asari 20 grams of Folium Sennae 15 grams of Cortex Meliaees 6 grams
The Rhizoma Pinelliae 10 grams of Fructus Mumes 10 grams of Alumens 20 grams
Semen Torreyae 30 grams
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Semen Arecae: pick decontamination, soaks with clear water, changes water, to soaking, pick up by temperature situation, and section, dries;
2, Cortex Magnoliae Officinalis: be soaked in water and pull out, scrapes off rough bark after running through, and clean, shredding, dries;
3, Semen Quisqualis: except decapsidate, gets clean core;
4, Pericarpium Zanthoxyli: removing fruit stem and seed Semen zanthoxyli, to put in pot stir-fry to making sound, oil goes out, take out, cool;
5, Pericarpium Arecae: pick clean impurity, rolloff makes soft, beats, sieve removes spare;
6, Endothelium Corneum Gigeriae Galli: pick decontamination, rinses and dries;
7, Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;
8, Herba Lysimachiae: pick clean impurity, sieve dedust bits, dry;
9, Fructus Jujubae: pick clean impurity, dry;
10, Rhizoma Zingiberis: pick clean impurity, be soaked in water 3-6 hour, pulls out, cuts into slices or dice, dry after moistening;
11, Radix et Rhizoma Rhei (stir-fried with wine): get rhubarb tablets yellow wine and evenly spray, micro-stewing, put the micro-stir-fry of the interior slow fire of pot, taking-up is dried, rhubarb tablets 100 jin, with yellow wine 14 jin;
12, Herba Taraxaci: pick decontamination, clean earth, cutting, dries;
13, Herba Pogostemonis: pick decontamination, removing undesirable root and old stem, first taken by leaf and separately put, stem water runs through, and cutting is dried, then with leaf and even;
14, Rhizoma Osmundae: slightly soak with clear water, takes out, and each watering sooner or later once, softens, and section, dries;
15, Concha Ostreae: clean, dry, pulverize use;
16, Herba Asari: Ex-all impurity, by water spray profit, timely cutting, dries;
17, Folium Sennae: get crude drug, except discarding stalk, impurity;
18, Cortex Meliae: clean, slightly soak, run through, shredding, dry;
19, the Rhizoma Pinelliae: pick decontamination, sieve dedust bits;
20, Fructus Mume: pick clean impurity, sieve dedust bits, clean, dry;
21, Alumen: pick clean impurity, the used time smashs to pieces;
22, Semen Torreyae: pick clean impurity, or shell and get core, the used time smashs to pieces.
1, the Semen Arecae of described weight, Cortex Magnoliae Officinalis, Fructus Quisqualis, Pericarpium Zanthoxyli, Pericarpium Arecae, Endothelium Corneum Gigeriae Galli, Radix Codonopsis, Herba Lysimachiae, Fructus Jujubae, Rhizoma Zingiberis, Radix Et Rhizoma Rhei, Herba Taraxaci, Herba Pogostemonis, Rhizoma Osmundae, Concha Ostreae, Herba Asari, Folium Sennae, Cortex Meliae, the Rhizoma Pinelliae, Fructus Mume, Alumen, Semen Torreyae medicine are decocted with water secondary, add water 8 times amount for the first time, soak after 200 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 35 minutes, filter first time decoction liquor.
2, add water the medicinal residues of filtration 6 times amount, first boils with high heat, then use slow fire boiling 20 minutes, filters to obtain second time decoction liquor.
3, merge twice decoction liquor, be divided into 6 doses to take.
Medicine of the present invention has warming spleen and stomach for dispelling cold, dehumidifying, parasite killing, removing food stagnancy, and the function of spleen invigorating, is used for the treatment of ascariasis of biliary tract, short treating period, instant effect, has no side effect.
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples include animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 30ml/kg, and normal amount is 15ml/kg, and administering mode is administration by gavage administration, and every day, secondary, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The observations of [test example 2] Drug therapy ascariasis of biliary tract of the present invention
1, physical data
Accept ascariasis of biliary tract patient totally 178 examples for medical treatment.
2, diagnostic criteria
1. stomachache often bores the violent angor of top sample under the xiphoid-process that breaks out, patient's pale complexion, feel restless, dripping sweat, bend over to split with laughter, cry and shout incessantly, very painful, back can be takeed on to the right during abdominal colic and diffuse, but also can alleviate suddenly.Stomachache mostly is paroxysmal, interval outbreak, and the persistent period is different in size, after pain, as ordinary person's peace and quiet or can tease, or lethargy.This symptom is the feature of biliary ascariasis, helps diagnosis.Angor often in an endless stream enters caused by biliary tract in sphincter place or most adult because of polypide incarceration, and even angor is again and again shown effect, is difficult to alleviate.When sphincter is tired, lax, ascarid all enters biliary tract or exits biliary tract, temporary transient static time, symptom can respite.When there is biliary tract infection, then stomachache continues.When merging liver abscess, hepatic region, lower back distending pain can be had.When merging acute pancreatitis, stomachache extends in the middle part of upper abdomen, upper left abdomen and lower back.If ascarid causes biliary tract perforation, full abdomen continuing vigorous stomachache and peritoneal irritation sign can be there is.When ascarid causes hemobilia, the explosive pain of upper abdomen, slight jaundice and massive bleeding from upper digestive tract three can be had to levy.When biliary tract infection is serious, septicemia etc. can be there is.[cuisines China]
2. nausea and vomiting often has generation, how when angor, occurs together, can contain bile or xanthochromia ascarid in spew.What have is " retch ", and patient can not normally take food.
3. General Symptoms is early stage without heating of obviously feeling cold, and can have feel cold heating and jaundice when complicated with acute pyogenic cholangitis, cholecystitis.As concurrent liver abscess, subphrenic infection, septicemia etc., then there is the high heat of shiver with cold, even toxic shock etc.
(2) although the early stage upper angina abdominis of sign, abdomen is soft or only upper abdomen is deeply in slight tenderness, without muscle tonus, significantly different from other acute abdomen., as there is liver, gallbladder pyogenic infection, peritonitis, can there be peritoneal irritation sign in late period: abdominal tenderness, rebound tenderness and muscle tonus.Maybe can touch enlargement and have the liver, gallbladder etc. of tenderness.Due to biliary tract ascarid blocking or cholelithiasis depositing, or liver toxicity infringement, jaundice in various degree can be had.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, each serving with 1 dose, every day early, evening respectively takes 1 time, within 5 days, is a course for the treatment of, takes 4 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: ascariasis of biliary tract transference cure, observe half a year without bounce-back person;
Take a turn for the better: ascariasis of biliary tract symptom is obviously improved, and body constitution progressively strengthens;
Invalid: ascariasis of biliary tract symptom, without change, does not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy ascariasis of biliary tract patient 178 example of the present invention, effective 169 examples of result, obvious effective rate is 94.94%, and take a turn for the better 6 examples, and improvement rate is 3.37%, and invalid 3 examples, total effective rate is 98.31%.