CN106620361A

CN106620361A - Medicine for treating epidemic hemorrhagic fever and preparation method thereof

Info

Publication number: CN106620361A
Application number: CN201710133430.4A
Authority: CN
Inventors: 李子义
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-03-08
Filing date: 2017-03-08
Publication date: 2017-05-10

Abstract

The invention discloses a medicine for treating epidemic hemorrhagic fever and a preparation method thereof. The medicine is mainly prepared from flos lonicerae, radix isatidis, rhizoma anemarrhenae, rhizoma imperatae, radix scrophulariae, herba leonuri, rhizoma alismatis, rhizoma polygonati, gypsum, cortex mori, semen persicae, semen lepidii, radix ophiopogonis, herba houttuyniae, fructus gardenia, radix paeoniae rubra, radix linderae, rhizoma bletillae, haematitum and unprocessed rehmannia root according to a certain weight ratio. The medicine has the functions of clearing away heat and toxic materials, nourishing Yin and removing fire, inducing diuresis to reduce edema and clearing heat and cooling blood; when the medicine is used for treating epidemic hemorrhagic fever, the medicine is rapid in effect, excellent in curative effect and free of recurrence.

Description

It is a kind of to treat medicine of Hemorrhagic fever and preparation method thereof

Technical field

The present invention relates to a kind of treat medicine of Hemorrhagic fever and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Hemorrhagic fever, also known as HFRS, is the Important Infectious Diseases for endangering human health, is by popularity Hemorrhagic fever viruse（Hantaan virus）Cause, the disease of natural focus with muroid as major source of infection.The traditional Chinese medical science then thinks popular Property Hemorrhagic fever and qi depression to blood stasis, volt in heat toxin, deficiency of kidney-QI is relevant.Due to western medicine large side effects, therefore people are to effective There is great demand in the Chinese medicine for the treatment of Hemorrhagic fever, up to now, it has not been found that with regard to the relevant of the present invention Report.

The content of the invention

The present inventor have found effectively treatment popular finally according to the checking repeatedly of research and the clinical testing of theory of traditional Chinese medical science The medicine of property Hemorrhagic fever, so as to complete the present invention.

It is an object of the invention to provide a kind of Chinese medicine composition of effectively treatment Hemorrhagic fever.

Another object of the present invention just there is provided the preparation method of the Chinese medicine composition.

Medicine of the present invention be select honeysuckle, Radix Isatidis, the wind-weed, cogongrass rhizome, radix scrophulariae, motherwort, rhizoma alismatis, sealwort, gypsum, The root bark of white mulberry, peach kernel, lepidium seed, the tuber of dwarf lilyturf, cordate houttuynia, cape jasmine, the radix paeoniae rubrathe, the root of three-nerved spicebush, the bletilla striata, ochre, radix rehmanniae recen, the fruit of Chinese magnoliavine, akebi, too Son ginseng is combined preparation, causes each efficacy of drugs to produce synergy these drug regimens such that it is able to effectively treatment Hemorrhagic fever.Wherein, it is because that its nature and flavor is sweet from honeysuckle, trembles with fear, enter lung, stomach, there is heat-clearing, the function of removing toxic substances is controlled Warm disease heating, toxic-heat and blood stasis, large carbuncle, pyogenic infections, scrofula, anal fistula.It is because that its nature and flavor is bitter from Radix Isatidis, trembles with fear, enter liver, stomach blood Point, there is heat-clearing, to detoxify, the function of cool blood controls influenza, and epidemic meningitis, encephalitis, pneumonia, erysipelas, heat toxin sends out spot, and coma tells nosebleed, and pharynx is swollen, Mumps, pinkeye, sore rash.It is because that its nature and flavor is bitter from the wind-weed, trembles with fear, enter lung, stomach, kidney channel, there is nourishing Yin and falling fire, the work(of moisturize laxation Can, control dysphoria with smothery sensation and quench one's thirst, hectic fever due to yin labor heat, cough with lung heat, dry feces, difficult urination.It is because that its nature and flavor is sweet, cold with cogongrass rhizome, Enter lung, stomach, small intestinl channel, there is cool blood, stop blooding, heat-clearing, the function of diuresis controls pyreticosis polydipsia, spit blood, bleeding from five sense organs or subcutaneous tissue, lung heat breathes heavily urgency, stomach energy Hiccup, gonorrhoea, difficult urination, oedema, jaundice.It is because that its nature and flavor hardship is salty from radix scrophulariae, it is cool, enter lung, kidney channel, there is enriching yin, drop Fire, relieving restlessness, the function of removing toxic substances controls pyreticosis polydipsia, sends out spot, hectic fever due to yin labor heat, and night sleeps not peaceful, spontaneous sweating, Tianjin hinder constipation, nosebleed of spitting blood Blood, abscess of throat, carbuncle swells, scrofula.It is because that its nature and flavor is worked hard from motherwort, it is cool, enter pericardium, Liver Channel, there is a promoting blood circulation, dissolving stasis, Menstruation regulating, the function of the water that disappears, controls irregular menstruation, controls and Lou has difficult labour, placenta retension, postpartum anemic fainting, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, Rush down blood, carbuncle swells sore.It is because that its nature and flavor is sweet from rhizoma alismatis, trembles with fear, enter bladder warp, favourable water, excreting dampness, the function of expelling the heat-evil controls little Just unfavorable, oedema anus is expired, vomiting, rush down dysentery, phlegm and retained fluid, tinea pedis, gonorrhoea, hematuria.Be because its property sweet taste from sealwort, enter spleen, Lung, kidney channel, there is a tonifying middle-Jiao and Qi, embellish lung, the function of strengthening the bones and muscles, governance wasting fever and chills, tuberculosis hemoptysis, after being ill body void deficiency of food, muscles and bones Weakness, rheumatalgia pain, wind favus disease.Its property acrid-sweet flavor is because from gypsum, is trembled with fear, enter lung, stomach, it is raw with there is expelling pathogenic factors from muscles for clearing heat, The function that relieving restlessness is quenched the thirst, controls pyreticosis high fever and does not move back, and vexed coma, delirious speech is gone mad, thirsty and dry pharynx, and lung heat breathes heavily urgency, heatstroke spontaneous perspiration, stomach Headache due to fire-evil, toothache, heat toxin stops up Sheng, and spot dermexanthesis, aphthae forges deposited myogenic sore, ulcer sores are controlled outward, bursts and does not withdraw, soup Burning hot wound.It is because that its nature and flavor is sweet from the root bark of white mulberry, trembles with fear, enter lung, the spleen channel, there is removing heat from lung and relieving asthma, the function of line water detumescence controls lung heat Breath with cough, spit blood, oedema, tinea pedis, difficult urination.Its nature and flavor bitter sweet is because from peach kernel, is put down, enter the heart, liver, large intestine channel have broken The blood stasis of blood, moisturizes the function of sliding Jing, and controlling through closing ， Disorder lumps in the abdomen, pyreticosis stores blood, and blood-arthralgia, malaria, traumatic injury, blood stasis and swelling pain, blood is dry just It is secret.It is because that its nature and flavor is worked hard from lepidium seed, trembles with fear, enter lung, bladder warp, there is the function of lower gas water-filling, controls lung heap soil or fertilizer over and around the roots and breathe heavily urgency, phlegm and retained fluid Cough, oedema turgor.Its property sweet and slightly bitter taste is because from the tuber of dwarf lilyturf, is trembled with fear, enter lung, stomach, the heart channel of Hang-Shaoyin, there is a Yin nourishing and lung moistening, relieving restlessness that clears away heart-fire, The function of reinforcing stomach reg fluid, controls dryness of the lung dry cough, spits blood, spitting of blood, consumptive lung disease, lung carbuncle, consumptive disease dysphoria with smothery sensation, clear thirsty, pyreticosis Tianjin wound, dry throat mouth It is dry, constipation.It is because that its nature and flavor is pungent from cordate houttuynia, trembles with fear, enter meridian of Hand-TAI YIN, there is clearing heat and detoxicating, the function of inducing diuresis to remove edema controls lung Inflammation, lung abscess, hot dysentery, malaria, oedema, gonorrhoea, leukorrhea, carbuncle swells, hemorrhoid, prolapse of the anus, eczema, the favus of the scalp, mange.From cape jasmine be because It is bitter for its nature and flavor, to tremble with fear, enter the heart, liver, lung, stomach have heat-clearing, and purging intense heat, the function of cool blood controls pyreticosis restlessness of asrhenia type and insomnia, and jaundice is drenched Disease, quenches one's thirst, hot eyes, pharyngalgia, spits blood, and bleeding from five sense organs or subcutaneous tissue, bloody flux, hematuria, pathopyretic ulcer is sprained and swollen and ache.Its nature and flavor is because from the radix paeoniae rubrathe Hardship, is slightly cold, return liver warp, there is clearing heat and cooling blood, and the function of blood stasis removing analgesic is controlled warm poison and gone mad, hematemesis and epistaxis, red eye, swell pain, the liver depression side of body Bitterly, Amenorrhea dysmenorrhoea ， Epilepsy lump in the abdomen stomachache, injury from falling down, carbuncle swells sore.Be because that its nature and flavor is pungent from the root of three-nerved spicebush, temperature, enter spleen, lung, kidney, Bladder warp, there is pleasant, opens strongly fragrant, cold dispelling, the function of pain relieving, controls circulation of vital energy in the wrong direction chest and abdomen swelling and pain, and place food is discontented, and food, cold hernia, pin are told in gastric disorder causing nausea Gas, frequent urination.Its nature and flavor bitter sweet is because from the bletilla striata, it is cool, enter lung channel, there is tonifying lung, to stop blooding, detumescence is raw to see, the work(of sore Can, control lung and hinder hemoptysis, bleeding from five sense organs or subcutaneous tissue, metal-inflicted wound bleeding, swollen ulcer drug, canker sores, soup fire burn, rhagadia manus et pedis.From ochre be because It is bitter, sweet for its nature and flavor, it is slightly cold, Return liver, stomach, the heart channel of Hang-Shaoyin have calming the liver, and inverse, the function of cooling blood and hemostasis drops in important city, controls dizzy before head Dizzy, palpitaition is demented, frightened epilepsy, vomiting, gas, and cough and asthma is spitted blood, and nosebleed epistaxis, uterine bleeding is had blood in stool, hematuria.From radix rehmanniae recen be because It is sweet for its nature and flavor, to tremble with fear, the thoughts of returning home, liver and kidney channel have clearing heat and cooling blood, and yin-nourishing, the function of promoting the production of body fluid controls pyreticosis polydipsia, yin asthenia generating intrinsic heat, bone Labor heat is steamed, Heat Diabetes is spitted blood, bleeding from five sense organs or subcutaneous tissue, spot dermexanthesis.Its nature and flavor acid is because from the fruit of Chinese magnoliavine, temperature enters lung, kidney channel, holds back Lung, nourshing kidney is promoted the production of body fluid, and receives sweat, and the function of puckery essence is controlled the deficiency syndrome of the lung and breathed with cough, and dry makees thirsty, and spontaneous perspiration, night sweat, internal lesion caused by overexertion is thin thin, emission, Protracted dysentery and diarrhea.It is because that its nature and flavor is bitter from akebi, cool, enter the heart, small intestine, bladder warp have purging intense heat water-filling, promoting blood circulation work( Can, hot urination is controlled, stranguria with turbid discharge, oedema is irritable feverish sensation in chest, larynx numbness pharyngalgia, inflexible pain all over, women's Amenorrhea, alactation.From crown prince Ginseng is because its nature and flavor sweetness and bitterness, and tepor, enter the heart, spleen, the Jing of lung three have tonifying lung, the function of invigorating the spleen, controls cough due to deficiency of the lung, spleen eating less, Palpitaition mesh sweat, metal fatigue.

Specific embodiment

The drug dose of instant component is also that inventor summarizes what is drawn through groping in a large number, and the consumption of each component is following heavy All there is preferable curative effect in the range of amount：

15-25 gram of honeysuckle, 10-20 gram of Radix Isatidis, 10-15 gram of the wind-weed, 25-35 gram of cogongrass rhizome, 10-20 gram of radix scrophulariae, motherwort 5-15 gram, 10-15 gram of rhizoma alismatis, 10-20 gram of sealwort, 15-25 gram of gypsum, 5-15 gram of the root bark of white mulberry, 10-20 gram of peach kernel, lepidium seed 5- 15 grams, 5-15 gram of the tuber of dwarf lilyturf, 10-20 gram of cordate houttuynia, 10-20 gram of cape jasmine, 5-15 gram of the radix paeoniae rubrathe, 5-15 gram of the root of three-nerved spicebush, 10-20 gram of the bletilla striata, 5-15 gram of ochre, 15-20 gram of radix rehmanniae recen, 5-10 gram of the fruit of Chinese magnoliavine, 5-15 gram of akebi, 5-15 gram of radix pseudostellariae.

Preferably：

20 grams of honeysuckle, 15 grams of Radix Isatidis, 12 grams of the wind-weed, 30 grams of cogongrass rhizome, 15 grams of radix scrophulariae, 10 grams of motherwort, 12 grams of rhizoma alismatis is yellow 15 grams of essence, 20 grams of gypsum, 10 grams of the root bark of white mulberry, 15 grams of peach kernel, 10 grams of lepidium seed, 10 grams of the tuber of dwarf lilyturf, 15 grams of cordate houttuynia, 15 grams of cape jasmine, 10 grams of the radix paeoniae rubrathe, 10 grams of the root of three-nerved spicebush, 15 grams of the bletilla striata, 10 grams of ochre, 18 grams of radix rehmanniae recen, 8 grams of the fruit of Chinese magnoliavine, 10 grams of akebi, 10 grams of radix pseudostellariae.

The preparation method of medicine of the present invention is as follows

First, get the raw materials ready

1st, honeysuckle：Silt is weeded out, net impurity is picked；

2nd, Radix Isatidis：Net impurity is picked, is cleaned, run through, cut into slices, dried；

3rd, the wind-weed：Net impurity is picked, is hit with water and is washed, pulled out, softened, section is dried；

4th, cogongrass rhizome：Net impurity is picked, is cleaned, micro- profit, segment is dried, net chip of winnowing with a dustpan；

5th, radix scrophulariae：Net impurity is picked, except removing LU, is cleaned and is run through, cut into slices, dried；

6th, motherwort：Impurity is picked, is cleaned, run through, segment is dried；

7th, rhizoma alismatis：Impurity is picked, size stepping is soaked in water to eighty per cant thoroughly, pulls out, shines cool, vexed to moisten uniform to inside and outside humidity, cuts Piece, dries；

8th, sealwort：Clean soil, slightly moistens, section, dries；

9th, gypsum：Miscellaneous stone is removed, soil is cleaned, fritter is broken into；

10th, the root bark of white mulberry：Grey bits are brushed away, is cleaned, run through rear chopping, dried；

11st, peach kernel：Duricrust impurity is removed, is put in boiling water pot and is boiled to crust microcreping, pulled out, in immersion cold water, kind of a skin is removed in stranding, is shone It is dry, winnow with a dustpan net；

12nd, lepidium seed：Net impurity is picked, grey bits are weeded out；

13rd, the tuber of dwarf lilyturf：Net impurity is picked, is soaked in water, pulled out, pump the heart after running through, then cleaned and dry；

14th, cordate houttuynia：Impurity is removed, undesirable root is removed, segment is cleaned, is dried；

15th, cape jasmine：Grey bits are weeded out, impurity is picked, is pulverized and is sieved or cut off two ends；

16th, the radix paeoniae rubrathe：Crude drug is taken, impurity is removed, size stepping is cleaned, run through, shave, is dried, and weeds out chip；

17th, the root of three-nerved spicebush：Impurity is picked, separates size bar, noted changing water according to season with bubble thoroughly, prevent smelly, pulled out cut in time Piece, weeds out grey bits；

18th, the bletilla striata：Impurity is picked, is soaked in water, pulled out, dry in the air suitable to humidity, section is dried；

19th, ochre：Crude drug is taken, impurity is removed, cleaning, drying break into fragment or are ground into meal；

20th, radix rehmanniae recen：Crude drug is taken, impurity is removed, is cleaned, slightly moistened, cut sheet, be dried, weed out chip；

21st, the fruit of Chinese magnoliavine：Grey bits are weeded out, impurity is removed, is put and steam in food steamer saturating, taking-up is dried；

22nd, akebi：Slightly soaked with water, it is vexed to moisten to saturating, section, dry；

23rd, radix pseudostellariae：Fibrous root is extractd, is dried.

2nd, prepare

1st, by the honeysuckle of the weight, Radix Isatidis, the wind-weed, cogongrass rhizome, radix scrophulariae, motherwort, rhizoma alismatis, sealwort, gypsum, Sang Bai Skin, peach kernel, lepidium seed, the tuber of dwarf lilyturf, cordate houttuynia, cape jasmine, the radix paeoniae rubrathe, the root of three-nerved spicebush, the bletilla striata, ochre, radix rehmanniae recen, the fruit of Chinese magnoliavine, akebi, radix pseudostellariae It is put into decocting container, adds water for the first time 8 times and measure, after immersion 100 minutes, fries by intense fire to boil and rise, then with being cooked by slow fire 20 minutes, First time decoction liquor is filtered to obtain, first time decoction liquor is poured into container；

2nd, the dregs of a decoction of filtration are added water 5 times and is measured, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second decoction liquor；

3rd, will decoction liquor mixing and stirring twice, be divided into 3 doses and take.

It is monarch drug in a prescription that honeysuckle has clearing heat and detoxicating function in prescription；Wind-weed nourishing Yin and falling fire, moisturize laxation；Cordate houttuynia heat-clearing solution Poison, inducing diuresis to remove edema, the two is ministerial drug, and three taste medicines play clearing heat and detoxicating, nourishing Yin and falling fire, moisturize laxation, the work of inducing diuresis to remove edema jointly With, treatment epizootic hemorrhagic thermal effect comprehensively, and with clearing heat and detoxicating, nourishing Yin and falling fire, can effect a permanent cure based on inducing diuresis to remove edema, radix rehmanniae recen has Clearing heat and cooling blood, yin-nourishing, the function of promoting the production of body fluid is adjutant, and radix scrophulariae has enriching yin, and fall fire, relieving restlessness, the function of removing toxic substances is all with being left to make medicine Medicine is to take stopgap measures.

Medicine of the present invention has clearing heat and detoxicating, nourishing Yin and falling fire, inducing diuresis to remove edema, the function of clearing heat and cooling blood, for treating prevalence Property Hemorrhagic fever, short treating period, instant effect, non-relapse after healing.

The beneficial effect of medicine of the present invention is expanded on further below by way of test example, these test examples are including this The animal toxicity test report of bright medicine and clinical observation on the therapeutic effect data.

The animal toxicity test report of [test example 1] medicine of the present invention：

Rabbit 30 is taken, male and female dual-purpose, 2.0-2.5kg of body weight is divided to two groups, and 15 per group, one of which is overdose test Group, another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is given for administration by gavage Medicine, twice daily, serve on 7 days, the reaction of observation administration daily, as a result shows that two groups of rabbit activities, diet are normal, and medicine is without bad Toxic and side effect.

The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention

1st, physical data

Accept Hemorrhagic fever out-patient totally 14 for medical treatment.

2nd, diagnostic criteria

Classical symptom is to show as heating, bleeding, hyperemia, hypotensive shock and kidney damage etc..

3rd, treatment method

From above-mentioned medicament, take to patient, each take 1 dose, it is early, middle and late daily respectively to take 1 time, it is within 10 days a course for the treatment of, even It is continuous to take 3 courses for the treatment of.

4th, efficacy assessment standard

It is effective：Hemorrhagic fever symptom disappears, and physique recovers normal, recovery from illness；

Take a turn for the better：The phenomenon of patient's heating, bleeding, hyperemia, hypotensive shock and kidney damage mitigates, and Hemorrhagic fever symptom is bright It is aobvious to take a turn for the better, progressively recover；

It is invalid：Improvement standard person is not reached.

5th, treatment results（See the table below）

In above-mentioned treatment, with drug therapy Epidemic Hemorrhagic Fever of the present invention 14, as a result effective 10, obvious effective rate is 71.43%, take a turn for the better 3, improvement rate is 21.43%, and invalid 1, total effective rate is 92.86%.

Claims

1. a kind of medicine for treating Hemorrhagic fever, it is characterised in that：It is made up of the bulk drug in following weight range：

2. medicine according to claim 1, wherein the consumption of each bulk drug is：

3. the preparation method of medicine according to claim 1 or claim 2, it comprises the following steps：

（One）Get the raw materials ready

（1）Honeysuckle：Silt is weeded out, net impurity is picked；

（2）Radix Isatidis：Net impurity is picked, is cleaned, run through, cut into slices, dried；

（3）The wind-weed：Net impurity is picked, is hit with water and is washed, pulled out, softened, section is dried；

（4）Cogongrass rhizome：Net impurity is picked, is cleaned, micro- profit, segment is dried, net chip of winnowing with a dustpan；

（5）Radix scrophulariae：Net impurity is picked, except removing LU, is cleaned and is run through, cut into slices, dried；

（6）Motherwort：Impurity is picked, is cleaned, run through, segment is dried；

（7）Rhizoma alismatis：Impurity is picked, size stepping is soaked in water to eighty per cant thoroughly, pulls out, shines cool, vexed to moisten uniform to inside and outside humidity, Section, dries；

（8）Sealwort：Clean soil, slightly moistens, section, dries；

（9）Gypsum：Miscellaneous stone is removed, soil is cleaned, fritter is broken into；

（10）The root bark of white mulberry：Grey bits are brushed away, is cleaned, run through rear chopping, dried；

（11）Peach kernel：Duricrust impurity is removed, is put in boiling water pot and is boiled to crust microcreping, pulled out, in immersion cold water, kind of a skin is removed in stranding, is shone It is dry, winnow with a dustpan net；

（12）Lepidium seed：Net impurity is picked, grey bits are weeded out；

（13）The tuber of dwarf lilyturf：Net impurity is picked, is soaked in water, pulled out, pump the heart after running through, then cleaned and dry；

（14）Cordate houttuynia：Impurity is removed, undesirable root is removed, segment is cleaned, is dried；

（15）Cape jasmine：Grey bits are weeded out, impurity is picked, is pulverized and is sieved or cut off two ends；

（16）The radix paeoniae rubrathe：Crude drug is taken, impurity is removed, size stepping is cleaned, run through, shave, is dried, and weeds out chip；

（17）The root of three-nerved spicebush：Impurity is picked, separates size bar, noted changing water according to season with bubble thoroughly, prevent smelly, pulled out in time Section, weeds out grey bits；

（18）The bletilla striata：Impurity is picked, is soaked in water, pulled out, dry in the air suitable to humidity, section is dried；

（19）Ochre：Crude drug is taken, impurity is removed, cleaning, drying break into fragment or are ground into meal；

（20）Radix rehmanniae recen：Crude drug is taken, impurity is removed, is cleaned, slightly moistened, cut sheet, be dried, weed out chip；

（21）The fruit of Chinese magnoliavine：Grey bits are weeded out, impurity is removed, is put and steam in food steamer saturating, taking-up is dried；

（22）Akebi：Slightly soaked with water, it is vexed to moisten to saturating, section, dry；

（23）Radix pseudostellariae：Fibrous root is extractd, is dried；

（Two）Prepare

（1）By the honeysuckle of the weight, Radix Isatidis, the wind-weed, cogongrass rhizome, radix scrophulariae, motherwort, rhizoma alismatis, sealwort, gypsum, Sang Bai Skin, peach kernel, lepidium seed, the tuber of dwarf lilyturf, cordate houttuynia, cape jasmine, the radix paeoniae rubrathe, the root of three-nerved spicebush, the bletilla striata, ochre, radix rehmanniae recen, the fruit of Chinese magnoliavine, akebi, radix pseudostellariae It is put into decocting container, adds water 8 times and measure, after soaking 100 minutes, fry by intense fire to boil and rise, then with being cooked by slow fire 20 minutes, filters First time decoction liquor, first time decoction liquor is poured into container；

（2）The dregs of a decoction of filtration are added water 5 times and is measured, boiled by intense fire, then with being cooked by slow fire 20 minutes, filter to obtain second decoction liquor；

（3）Decoction liquor mixing and stirring twice is incited somebody to action, is divided into 3 doses and is taken.