CN103623128B

CN103623128B - Medicine for treating optic atrophy and preparation method thereof

Info

Publication number: CN103623128B
Application number: CN201310672825.3A
Authority: CN
Inventors: 苏振华
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-12-12
Filing date: 2013-12-12
Publication date: 2015-07-08
Anticipated expiration: 2033-12-12
Also published as: CN103623128A

Abstract

The invention discloses a medicine for treating optic atrophy and a preparation method thereof. The medicine is mainly prepared from medicines, namely, black soybean, bryozoatum, plastrum testudinis and the like according to a certain weight ratio. The medicine disclosed by the invention has the functions of enriching yin and nourishing kidney, activating blood and alleviating water retention, and dispelling the wind and detoxifying, and is rapid to take effect, good in curative effect and has no side effects when being used for treating optic atrophy.

Description

A kind of medicine for the treatment of optic atrophy and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of optic atrophy and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Optic atrophy refers to that optic nerve fiber generation degeneration and conduction function obstacle and all diseases of optic nerve lesion that causes all can cause optic atrophy.Mainly visual deterioration, severe patient can be as blind as a bat, constriction of visual field or have central scotoma, and have dyschromatopsia.Primary optic atrophy is pale asphyxia depending on nipple, and the aperture of its boundary and sieve plate is clear, and retinal vessel attenuates, and blood capillary disappears.Secondary optic atrophy, be canescence, wax yellow or pale red depending on nipple, boundary is fuzzy, and physiological depression disappears, and sieve plate hole is unintelligible, and retinal vessel attenuates, and tremulous pulse is with white sheath sometimes.Because Western medicine effectively cannot treat optic atrophy, and take Western medicine and have more side effect, costly, therefore there is great demand in the Chinese medicine of people to rapid, effective treatment optic atrophy, up to now, also do not find about relevant report of the present invention.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally have found the medicine of effectively treatment optic atrophy, thus completes the present invention.

Object of the present invention is just to provide a kind of Chinese medicine composition of more effective treatment optic atrophy.

Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.

Medicine of the present invention selects Semen sojae atricolor, Pumex, Carapax et Plastrum Testudinis, Magnetitum, Concha Margaritifera, Fructus Lycii medicine to carry out combination preparation, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat the recurrence of optic atrophy.Select Semen sojae atricolor to be because its nature and flavor are sweet, flat, enter spleen, kidney channel, invigorate blood circulation, diuretic, dispel the wind, the function of removing toxic substances, swelling of harnessing the river is full, pathogenic wind-toxic beriberi, jaundice clonic spasm of the muscle, puerperal puerperal tetanus, locked mouth, carbuncle sore tumefacting virus; Separate poison of drug.Select Pumex to be because its nature and flavor are salty-cold, enter lung, stomach warp, have lung heat clearing fire, change old expectorant, softening the hard mass, treating stranguria function, control expectorant dyspnea of heat type and cough, old accumulation of phlegm block, goiter, scrofula, hernia, skin ulcer swells, corneal nebula.Select Carapax et Plastrum Testudinis to be because its nature and flavor are salty sweet, flat, enter liver, kidney channel, have YIN nourishing, YANG hyperactivity suppressing, the kidney invigorating, the function of strong bone, controls deficiency of kidney yin, hectic fever due to YIN-deficiency consumptive fever, spits blood, epistaxis, chronic cough, seminal emission, metrorrhagia, leukorrhagia, lumbago, the atrophic debility of bones, stirring of wind due to deficiency of YIN, chronic dysentery, chronic malaria, hemorrhoid, non-closure of fontanels jin infants.Select Magnetitum to be because its nature and flavor are pungent salty, flat, enter kidney, liver, lung meridian, have calming down the floating YANG to promote inspiration for relieving dyspnea, the function of tranquillizing the mind by relieving convulsion, controls the vertigo, Hiccough and deaf, dyspnea due to deficiency ， Jing Epilepsy, palpitation with a distress feeling.Select Concha Margaritifera to be because its nature and flavor are salty, cool, enter the heart, liver two warp, have suppressing the hyperactive liver, YANG hyperactivity suppressing, arresting convulsion, the function of hemostasis, controls dizziness, tinnitus, cardiopalmus, insomnia, and demented ， Jing Epilepsy is spitted blood, epistaxis, metrorrhagia.Select Fructus Lycii to be that flat, have nourishing kidney, lung moistening, tonifying liver, the function of improving eyesight, controls hepatic and renal YIN deficiency, and soreness of the waist and knees is had a dizzy spell, the many tear of blurred vision, and cough due to consumptive disease, quenches one's thirst because its nature and flavor are sweet, lose clear.

Detailed description of the invention

The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight

Semen sojae atricolor 15-25 gram of Pumex 15-25 gram of Carapax et Plastrum Testudinis 10-20 gram

Magnetitum 10-20 gram of Concha Margaritifera 15-25 gram of Fructus Lycii 10-20 gram

Be preferably

Semen sojae atricolor 20 grams of Pumexs 20 grams of Carapax et Plastrum Testudinis 15 grams

Magnetitum 15 grams of Concha Margaritiferas 20 grams of Fructus Lycii 15 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Semen sojae atricolor: pick clean impurity, dry;

2, Pumex: clean, dry, smash;

3, Carapax et Plastrum Testudinis: soak with clear water, scrape off residual meat, cleans, dries, knock fritter;

4, Magnetitum: pick decontamination, smashes, and sieves;

5, Concha Margaritifera: pick decontamination, knock fragment, sieve dedust bits;

6, Fructus Lycii: clean impurity of winnowing with a dustpan, plucks residual stalk and the base of a fruit.

Two, prepare

1, the Semen sojae atricolor of described weight, Pumex, Carapax et Plastrum Testudinis, Magnetitum, Concha Margaritifera, Fructus Lycii are put into 2000 grams of Chinese liquor to add a cover slow fire and simmer 30 minutes.

2, well-done said medicine is placed in watt upper slow fire to dry, then pulverizes respectively, be ground into smalls.

3, the smalls of grinding is incapsulated and get final product.

Medicine of the present invention has the function of YIN nourishing, the kidney invigorating, improving eyesight, is used for the treatment of optic atrophy instant effect, good effect.

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test and the clinical observation on the therapeutic effect test of medicine of the present invention.

The animal toxicity test of [test example 1] medicine of the present invention

Get West Germany rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, another group is normal amount test group, be mixed with suspension for West Germany's rabbit test with distilled water, overdose test group is 25ml/kg, and dosage is 0.4 gram/kg, normal amount is 10ml/kg, dosage is 0.2 gram/kg, and administering mode is administration by gavage administration, every day secondary, serve on 7 days, observe administration reaction every day, result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's totally 100 examples for medical treatment.

2, diagnostic criteria

Optic atrophy is the final result of optic nerve disease damage.Show as degeneration and the disappearance of optic nerve fiber, conduction function obstacle, occur that the visual field changes, visual deterioration is also lost.Generally be divided into constitutional and Secondary cases two class, except above-mentioned symptom, examination of ocular fundus is yellowish or pale asphyxia depending on nipple color still as seen, and boundary is fuzzy, and physiological depression disappears, and blood vessel attenuates.

3, Therapeutic Method

Select above-mentioned medicament, take to patient's bath, each 10 grams, every day twice 15 days is a course for the treatment of, takes three courses for the treatment of continuously.

4, efficacy assessment standard

Effective: optic atrophy symptom is almost recovered, remaining nerve fiber recovers normal function;

Take a turn for the better: optic atrophy symptom alleviates, and the state of an illness progressively takes a turn for the better;

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form):

In above-mentioned treatment, by Drug therapy optic atrophy 100 example of the present invention, effective 86 examples of result, obvious effective rate is 86%, and take a turn for the better 4 examples, and improvement rate is 4%, and invalid 10 examples, total effective rate is 90%.

Claims

1. treat a medicine for optic atrophy, it is characterized in that: it is made up of the crude drug in following weight range:

Magnetitum 10-20 gram of Concha Margaritifera 15-25 gram of Fructus Lycii 10-20 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Magnetitum 15 grams of Concha Margaritiferas 20 grams of Fructus Lycii 15 grams.

3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:

(1) get the raw materials ready

(1) Semen sojae atricolor: pick clean impurity, dry;

(2) Pumex: clean, dry, smash;

(3) Carapax et Plastrum Testudinis: soak with clear water, scrape off residual meat, cleans, dries, knock fritter;

(4) Magnetitum: pick decontamination, smashes, and sieves;

(5) Concha Margaritifera: pick decontamination, knock fragment, sieve dedust bits;

(6) Fructus Lycii: clean impurity of winnowing with a dustpan, plucks residual stalk and the base of a fruit;

(2) prepare

(1) Semen sojae atricolor of described weight, Pumex, Carapax et Plastrum Testudinis, Magnetitum, Concha Margaritifera, Fructus Lycii are put into 2000 grams of Chinese liquor to add a cover slow fire and simmer 30 minutes;

(2) well-done said medicine is placed in watt upper slow fire to dry, then pulverizes respectively, be ground into smalls;

(3) smalls of grinding is incapsulated and get final product.