CN103736041A - Drug for treating schizophrenia and preparation method thereof - Google Patents
Drug for treating schizophrenia and preparation method thereof Download PDFInfo
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- CN103736041A CN103736041A CN201310678565.0A CN201310678565A CN103736041A CN 103736041 A CN103736041 A CN 103736041A CN 201310678565 A CN201310678565 A CN 201310678565A CN 103736041 A CN103736041 A CN 103736041A
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Abstract
The invention discloses a drug for treating schizophrenia and a preparation method thereof. The drug is prepared from the following medicinal materials according to a certain weight ratio: Chinese gentian, oyster, peach seed, agilawood, iron fillings, alpinia oxyphylla, red tangerine peel, and medicated leaven. The drug has the functions of clearing heat, calming liver, extinguishing wind, arresting convulsion, nourishing heart, and quieting spirit, and has the advantages of rapid effect, good curative effect, and no relapse.
Description
Technical field
The present invention relates to one and treat schizoid medicine and preparation method thereof, belong to the field of Chinese medicines.
Technical background
Schizophrenia is one group of major psychosis that the cause of disease is not bright, the how slow or subacute onset person between twenty and fifty, often show as clinically the different syndrome of symptom, relate to the inharmonious of many-sided obstacles such as sensory perception, thinking, emotion and behavior and ergasia.The general Clear consciousness of patient, intelligent normal, but some patients were there will be the infringement of cognitive function in lysis.The course of disease is generally delayed, and is repeatedly and shows effect, increases the weight of or worsen, and decline and mental handicap finally appear in some patients were.At present, western medicine schizophrenia poor effect, and long-term taking Western medicine has more side effect, therefore, there is very large demand to the schizoid Chinese medicine of effective treatment in people.
Summary of the invention
The inventor, according to the research of theory of Chinese medical science and clinical test and checking repeatedly, has finally found the schizoid medicine of effective treatment, thereby has completed the present invention.
Object of the present invention is just to provide one can effectively treat schizoid composition of medicine.
Another object of the present invention has just been to provide the preparation method of this composition of medicine.
Medicine of the present invention selects Radix Gentianae, Concha Ostreae, Semen Persicae, Lignum Aquilariae Resinatum, pulvis ferri (ferrosic oxide), Fructus Alpiniae Oxyphyllae, Exocarpium Citri Rubrum, Massa Medicata Fermentata, Semen Pruni, Cortex Albiziae, Ramulus Uncariae Cum Uncis, Lapis Micae Aureus, Scorpio, Radix Achyranthis Bidentatae, Flos Hibisci Mutabilis, Caulis Bambusae In Taenia, Folium Camelliae sinensis, Rhizoma Zingiberis Recens, Caulis Polygoni Multiflori, Fructus Gardeniae, Flos Inulae, Radix Knoxiae, Semen Arecae, Fructus Tribuli, Radix Salviae Miltiorrhizae, Semen Sinapis Albae, Semen Tritici aestivi, Semen Pharbitidis, Radix Polygoni Multiflori, Semen Platycladi, Radix Asparagi, Radix Et Rhizoma Rhei, Bulbus Lilii medicine to combine, make each efficacy of drugs produce synergism these drug regimens, thus can the schizoid recurrence of fast treating.Wherein select Radix Gentianae to be because its nature and flavor hardship is cold, enter liver, gallbladder meridian, have eliminating pathogen in the liver excess-fire, except the function of damp-heat in lower-JIAO, treating the liver is manic through intenseness of heat ， Jing Epilepsy, encephalitis B, and headache, conjunctival congestion, pharyngalgia, jaundice, hematodiarrhoea, carbuncle skin infection, scrotum swells and ache, pudendum pruritus due to damp pathogen.Select Concha Ostreae to be because its nature and flavor are salty and bitter, cool, enter liver, kidney channel, have yin fluid astringing, YANG hyperactivity suppressing, hidroschesis, arresting seminal emission, reduces phlegm, the function of softening the hard mass, Zhi Jing Epilepsy, dizzy, spontaneous perspiration, night sweat, seminal emission, stranguria with turbid discharge, metrorrhagia, leukorrhagia, scrofula, goiter.Select Semen Persicae to be because its property bitter but sweet flavor is flat, enter the heart, liver, large intestine channel, have blood stasis removing and clots absorbing, moisturize the function of sliding warp, control amenorrhea, mass in the abdomen, calentura blood-retention, arthralgia due to stagnation of blood, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Select Lignum Aquilariae Resinatum to be because its nature and flavor are arduous, enter kidney, spleen, stomach warp, have sending down the abnormal ascending QI warming middle-JIAO, the function of warming the kidney improving inspiration by invigorating kidney-QI, controls QI rising in reverse order and pants, vomiting singultus, abdominal distention, waist knee joint cold caused by deficiency, large intestine constipation due to insufficiency, urine qi stranguria, man's cold sperm.Select pulvis ferri (ferrosic oxide) to be because its nature and flavor are pungent, cool, have the function of checking hyperfunction of the liver for relieving convulsion, control demented, calentura delirium, cardiopalmus, easily frightened susceptible to get angry, sore swollen toxin.Select Fructus Alpiniae Oxyphyllae to be because its nature and flavor are pungent, temperature, enters spleen, kidney channel, has warming the spleen, warming the kidney, solid and gas, the function of arresting seminal emission, controls cold air stomachache, invasion by pathogenic cold is vomited and diarrhoea, many salivas, seminal emission, dribbling urination, night many urine.Select Exocarpium Citri Rubrum to be because its nature and flavor are arduous, temperature, enters brothers' sun, the sun, Yangming Channel, has expectorant, promoting the circulation of QI, and alleviating distention in middle-JIAO, the function of eliminating stagnation, controls wind and cold phlegmatic cough, feels sick, guttation, chest pain feeling of distension and oppression.Select Massa Medicata Fermentata to be because its nature and flavor sweet, acrid, warm enters upright stone tablet, stomach warp, have invigorating the spleen and regulating the stomach, the function helping digestion in adjusting, controls retention of food and drink, feeling of stuffiness in chest abdominal distention, and vomiting dysentery, postnatal blood stasis stomachache, children's's enlarged abdomen is hard long-pending.Select Semen Pruni to be because its nature and flavor are arduous sweet, flat, enter spleen, intestine and small intestine warp, have and moisturize, laxation, the therapeutic method to keep the adverse QI flowing downwards, the function of diuretic, controls QI stagnation of the large intestine, dry puckery obstructed, dysuria, extensive abdominal edema, extremity edema, beriberi.Select Cortex Albiziae to be because its nature and flavor are sweet, flat, enter the heart, Liver Channel, there is resolving depression, and blood, mind calming, the function of subduing inflammation, controls irritability, melancholy insomnia, lung abscess, carbuncle, scrofula, injured bone.Select Ramulus Uncariae Cum Uncis to be because its nature and flavor hardship is cool, enter liver, heart channel, have heat clearing away suppressing the hyperactive liver, the function of the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., controls little Jing Epilepsy Chi Zong, and adult's blood pressure is higher, dizzy, dizzy, married woman's eclampsia.Select Lapis Micae Aureus to be because its nature and flavor are sweet, salty, flat, return lung, the heart, Liver Channel, there is the pendant expectorant therapeutic method to keep the adverse QI flowing downwards, the function of checking hyperfunction of the liver for relieving convulsion, controls pertinacious phlegm cementing, cough with dyspnea dyspnea with rapid respiration, epilepsy is gone mad, fidgety uncomfortable in chest, and infantile convulsion knots.Scorpion chosen because of its salty taste acrid, flat, toxic, chills, antispasmodic, meridians, detoxification function, governance convulsion convulsions, epilepsy, stroke, hemiplegia, eye and mouth wo oblique, migraines, rheumatism arthralgia, tetanus, lymph node tuberculosis, rubella sores.Select Radix Achyranthis Bidentatae to be because its nature and flavor sweetness and bitterness acid is flat, enter liver, kidney channel, dissipating blood stasis blood is used in life, and subduing inflammation, controls gonorrhea, hematuria, amenorrhea ， mass in the abdomen, difficult labour, retention of placenta, postnatal blood stasis stomachache, sore throat, carbuncle, traumatic injury, ripe in invigorating the liver and kidney, bone and muscle strengthening, controls waist kneecap pain, four fertile contractures, flaccidity syndrome and arthralgia syndrome.Select Flos Hibisci Mutabilis to be because its nature and flavor are micro-pungent, cool, return lung, Liver Channel, have Qingfei Liangxue, heat radiation removing toxic substances, the function of detumescence and apocenosis, controls cough due to lung-heat, scrofula, acute appendicitis, leucorrhea, furuncle abscess, glue ear, innominate toxic swelling, burn are controlled in external.Select Caulis Bambusae In Taenia to be because its nature and flavor are sweet, cool, enter stomach, gallbladder meridian, have heat clearing away, removing heat from blood, reduces phlegm, and the function of emesis is controlled dysphoria with smothery sensation vomiting, singultus, and expectorant heat syndrome cough is breathed heavily, spit blood, and epistaxis, metrorrhagia, malignant histocytosis, fetal movement ， Jing Epilepsy.Selecting Folium Camelliae sinensis is that cool, GUIXIN lung stomach warp, has and reduce phlegm because of its property bitter but sweet flavor, helps digestion, and the function of diuresis removing toxic substances, controls headache blurred vision, and food stagnation expectorant is stagnant, malaria, dysentery.Select Rhizoma Zingiberis Recens to be because its nature and flavor are pungent, temperature, enters lung, stomach, spleen channel, deliver, and cold expelling, preventing or arresting vomiting, opens the function of expectorant, the wind and cold that cures cold, vomiting, phlegm retention, breathes with cough, and distension is had loose bowels, and separates the Rhizoma Pinelliae, Rhizoma Arisaematis and fish Eriocheir sinensis, birds and beasts meat poisoning.Select Caulis Polygoni Multiflori to be because its property sweet and slightly bitter taste is flat, enter the heart, Liver Channel, nourish heart, calm the nerves, dredging collateral, the function of dispeling the wind, controls insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies.Select Fructus Gardeniae to be because its nature and flavor hardship is cold, enter the heart, liver, lung, stomach warp, have heat clearing away, pathogenic fire purging, the function of removing heat from blood, controls calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea, quenches one's thirst, conjunctival congestion, pharyngalgia, spits blood, epistaxis, dysentery, hematuria, pathopyretic ulcer, sprains and swells and ache.Select Flos Inulae to be because its nature and flavor are salty, temperature, enters lung, liver, stomach warp, has expectorant, the therapeutic method to keep the adverse QI flowing downwards, and softening the hard mass, the function of row water, controls in the heart expectorant knot, the lower distension of the side of body, cough with asthma, singultus, saliva is as shellac varnish, epigastric oppression and rigidity, eructation unrelieved, extensive abdominal edema.Select Radix Knoxiae to be because its nature and flavor hardship is cold, slightly poisonous, return lung, spleen, kidney channel, have removing fluid-retention by purgation, counteracting toxic substances, the function of dispersing swelling and dissipating binds, controls breast abdomen hydrops, difficulty in urination and defecation, carbuncle sore tumefacting virus, scrofula sucutaneous nodule.Selecting Semen Arecae is that temperature, enters spleen, stomach, large intestine channel, has parasite killing because of its nature and flavor toil, removing mass, and the therapeutic method to keep the adverse QI flowing downwards, the function of row water, controls malnutrition due to parasitic infestation, dyspepsia, and abdominal distention is heavy after dysentery, malaria, edema, beriberi, accumulation of phlegm in the hypochondrium ， Disorder knot.Selecting Fructus Tribuli is because its nature and flavor toil, and temperature, enters liver, lung meridian, has loose wind, improving eyesight, and the therapeutic method to keep the adverse QI flowing downwards, the function of promoting the circulation of blood, controls headache, itching over the body, the conjunctival congestion nebula that swell, fullness in the chest, cough with dyspnea ， mass in the abdomen, breast difficulty, carbuncle, scrofula.Selecting Radix Salviae Miltiorrhizae is that tepor, enters the heart, Liver Channel, has blood circulation and promoting silt because of its nature and flavor hardship, calming heart and tranquilizing mind, and evacuation of pus, the function of pain relieving, controls angina pectoris, menoxenia, dysmenorrhea, to close, metrorrhagia leukorrhagia ， mass in the abdomen, gathers, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.Select Semen Sinapis Albae to be because its nature and flavor are pungent, temperature, enters lung, stomach warp, has promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, and the function of removing obstruction in the collateral to relieve pain, controls phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain, regurgitation vomiting, aphasia due to apoplexy, limbs arthralgia pain numbness, beriberi, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.Select Semen Tritici aestivi to be because its nature and flavor are sweet, cool, enter the heart, spleen, kidney channel, nourish heart, kidney tonifying, heat extraction, the function of quenching the thirst, controls hysteria, and dysphoria with smothery sensation is quenched one's thirst, and lets out profit, carbuncle, traumatic hemorrhage, scalds.Select Semen Pharbitidis to be because its nature and flavor hardship is cold, poisonous, return lung, kidney, large intestine channel, have removing water retention by purgation relieving constipation, drink is washed in expectorant, and parasite killing is attacked long-pending function, the swelling pain of harnessing the river, and constipation and anuresis, phlegm retention is gathered, and QI rising in reverse order is breathed with cough, abdominal pain due to worm stagnation, ascarid, taeniasis.Select Radix Polygoni Multiflori to be because its property bitter but sweet flavor is puckery, tepor, enters liver, kidney channel, has tonifying liver, and kidney tonifying, nourishes blood, the function of dispeling the wind, control hepatic and renal YIN deficiency, sending out must be early white, blood deficiency dizziness, and waist knee joint weakness, muscles and bones is ached, seminal emission, metrorrhagia and leukorrhagia, chronic malaria, chronic dysentery, chronic hepatitis, carbuncle, scrofula, hemorrhoidal hamorrhage, haemorrhoids.Select Semen Platycladi to be because its nature and flavor are sweet, flat, enter the heart, liver, spleen channel, there is tranquilizing by nourishing the heart, the function of loosening bowel to relieve constipation, controls palpitation with fear, insomnia, seminal emission, night sweat, the function of constipation.Select Radix Asparagi to be because its nature and flavor sweetness and bitterness is cold, enter lung, kidney channel, have YIN nourishing, moisturize, lung heat clearing, the function of pathogenic fire reducing, controls fever due to yin deficiency, and cough is spitted blood, consumptive lung disease, lung abscess, laryngopharynx swelling and pain, quenches one's thirst, constipation.Select Radix Et Rhizoma Rhei to be because its nature and flavor hardship, cold enters stomach, large intestine, liver footpath, have the poison of purging heat, removing mass is stagnant, the function of clots absorbing blood, controls excess-heat constipation, and delirium is gone mad, food stagnation feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menolipsis Bi ， lumps in the chest and abdomen, time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia, spits blood, epistaxis, YANG jaundice, edema, stranguria with turbid discharge, urinates red, carbuncle and ulcer toxic swelling, furuncle, burn.Select Bulbus Lilii to be because its property sweet and slightly bitter taste is flat, enter the heart, lung meridian, have nourishing the lung to arrest cough, the function of clearing away heart-fire for tranquillization, controls pulmonary tuberculosis chronic cough, cough and spit expectorant blood, and after calentura, waste heat is unclear, fidgets due to deficiency palpitation with fear, staring spells, beriberi edema.
The specific embodiment
The drug dose of component of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight
Radix Gentianae 5-15 gram of Concha Ostreae 5-15 gram of Semen Persicae 5-15 gram
Lignum Aquilariae Resinatum 5-15 gram of pulvis ferri (ferrosic oxide) 25-35 gram of Fructus Alpiniae Oxyphyllae 10-20 gram
Exocarpium Citri Rubrum 5-15 gram of Massa Medicata Fermentata 5-15 gram of Semen Pruni 6-12 gram
Cortex Albiziae 5-15 gram of Ramulus Uncariae Cum Uncis 15-25 gram of Lapis Micae Aureus 15-25 gram
Scorpio 5-15 gram of Radix Achyranthis Bidentatae 10-20 gram of Flos Hibisci Mutabilis 10-20 gram
Caulis Bambusae In Taenia 10-20 gram of Folium Camelliae sinensis 1-10 gram of Rhizoma Zingiberis Recens 3-9 gram
Caulis Polygoni Multiflori 3-9 gram of Fructus Gardeniae 15-25 gram of Flos Inulae 5-15 gram
Radix Knoxiae 3-9 gram of Semen Arecae 5-15 gram of Fructus Tribuli 5-15 gram
Radix Salviae Miltiorrhizae 3-9 gram of Semen Sinapis Albae 3-9 gram of Semen Tritici aestivi 10-20 gram
Semen Pharbitidis 5-15 gram of Radix Polygoni Multiflori 5-15 gram of Semen Platycladi 6-12 gram
Radix Asparagi 5-15 gram of Radix Et Rhizoma Rhei 5-15 gram of Bulbus Lilii 5-15 gram
Preferable amount is
10 grams, 10 grams of Semen Persicaes of 10 grams of Concha Ostreaes of Radix Gentianae
15 grams of 30 grams of Fructus Alpiniae Oxyphyllae of 10 grams of pulvis ferri (ferrosic oxide) of Lignum Aquilariae Resinatum
9 grams of 10 grams of Semen Prunis of 10 grams of Massa Medicata Fermentata of Exocarpium Citri Rubrum
20 grams of 20 grams of Lapis Micae Aureuses of 10 grams of Ramulus Uncariae Cum Uncis of Cortex Albiziae
15 grams of 15 grams of Flos Hibisci Mutabilis of 10 grams of Radix Achyranthis Bidentataes of Scorpio
6 grams, 5 grams of Rhizoma Zingiberis Recenss of 15 grams of Folium Camelliae sinensis of Caulis Bambusae In Taenia
10 grams of 20 grams of Flos Inulae of 6 grams of Fructus Gardeniaes of Caulis Polygoni Multiflori
10 grams of 10 grams of Fructus Tribulis of 6 grams of Semen Arecaes of Radix Knoxiae
15 grams of 6 grams of Semen Tritici aestivis of 6 grams of Semen Sinapis Albaes of Radix Salviae Miltiorrhizae
9 grams of 10 grams of Semen Platycladi of 10 grams of Radix Polygoni Multiflori of Semen Pharbitidis
10 grams of 10 grams of Bulbus Liliies of 10 grams of Radix Et Rhizoma Rhei of Radix Asparagi
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Radix Gentianae: choose decontamination, remove residual stem, clean, run through rear cutting, dry;
2, Concha Ostreae: clean, dry, pulverize use;
3, Semen Persicae: remove duricrust impurity, put in boiling water pot and boil to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove seed coat, dry, winnow with a dustpan clean;
4, Lignum Aquilariae Resinatum: outwash, be split into fritter, the used time smashs to pieces;
5, pulvis ferri (ferrosic oxide): get the pulvis ferri (ferrosic oxide) of laying while forging iron, remove its coal soil impurity, clean, dry;
6, Fructus Alpiniae Oxyphyllae: get Fructus Alpiniae Oxyphyllae and put in pot, fry to shell burned blackly, take out coldly, remove shell, get core and smash use to pieces;
7, Exocarpium Citri Rubrum: choose decontamination, outwash, used time folding is broken;
8, Massa Medicata Fermentata: get wheat bran and sprinkle evenly in heat pot, the cigarette of having waited, pours Massa Medicata Fermentata into, fries to yellow, takes out, and sieve removes wheat bran, cools;
9, Semen Pruni: sieve removes spare, washes in a pan only, chooses clean impurity and broken shell, dries, and the used time smashs to pieces;
10, Cortex Albiziae: clear water soaks to be cleaned, and pulls out, is first divided into after moistening and equates large rectangular, then stripping and slicing or shredding, dry;
11, Ramulus Uncariae Cum Uncis: choose old stalk, impurity, clean, dry;
12, Lapis Micae Aureus: remove impurity, break into fragment;
13, Scorpio: clear water floats the matter that desalts, dries, or low baking temperature roasting is used;
14, Radix Achyranthis Bidentatae: choose decontamination, clean, soften, go reed, cutting, dries;
15, Flos Hibisci Mutabilis: remove impurity, dry;
16, Caulis Bambusae In Taenia: remove hard bamboo let, impurity, shake off ash bits, be kneaded into little group or cutting;
17, Folium Camelliae sinensis: after fresh leaf gathers, through completing, knead the dry green tea of making;
18, Rhizoma Zingiberis Recens: choose decontamination, clean earth, used time section;
19, Caulis Polygoni Multiflori: clear water is cleaned, slightly soaks, and pulls out, and after running through, cutting, dries;
20, Fructus Gardeniae: sieve dedust bits, choose decontamination, pulverize and sieve or cut off two ends;
21, Flos Inulae: choose clean impurity, except destemming leaf, sieve removes earth;
22, Radix Knoxiae: remove impurity, clean, run through, cut sheet or section, dry, sieve removes chip;
23, Semen Arecae: choose decontamination, soak with clear water, change water by temperature situation, till soaking, pick up, section, dries;
24, Fructus Tribuli: float silt, the hard thorn that Ex-all is residual;
25, Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;
26, Semen Sinapis Albae: the former medicine most impurity of winnowing with a dustpan, fry to buff, micro-have fragrance and get final product;
27, Semen Tritici aestivi: choose decontamination, winnow with a dustpan and only dry;
28, Semen Pharbitidis: get crude drug, remove impurity, flat grain and shell, the used time smashs to pieces;
29, Radix Polygoni Multiflori: choose decontamination, clean, saturating with blister to eighty per cant, to pull out, profit is even to inside and outside humidity, and section or dice, dry;
30, Semen Platycladi: choose clean impurity, remove residual shell and seed coat;
31, Radix Asparagi: choose decontamination, water is cleaned, and moistening is even to inside and outside humidity, cutting, dry;
32, Radix Et Rhizoma Rhei: choose clean impurity, big or small stepping, stewing profit is even to inside and outside humidity, cuts into slices or is cut into small pieces, dries;
33, Bulbus Lilii: choose decontamination, black lobe, the ash disposal of winnowing with a dustpan bits.
Two, preparation
1, the Radix Gentianae of described weight, Concha Ostreae, Semen Persicae, Lignum Aquilariae Resinatum, pulvis ferri (ferrosic oxide), Fructus Alpiniae Oxyphyllae, Exocarpium Citri Rubrum, Massa Medicata Fermentata, Semen Pruni, Cortex Albiziae, Ramulus Uncariae Cum Uncis, Lapis Micae Aureus, Scorpio, Radix Achyranthis Bidentatae, Flos Hibisci Mutabilis, Caulis Bambusae In Taenia, Folium Camelliae sinensis, Rhizoma Zingiberis Recens, Caulis Polygoni Multiflori, Fructus Gardeniae, Flos Inulae, Radix Knoxiae, Semen Arecae, Fructus Tribuli, Radix Salviae Miltiorrhizae, Semen Sinapis Albae, Semen Tritici aestivi, Semen Pharbitidis, Radix Polygoni Multiflori, Semen Platycladi, Radix Asparagi, Radix Et Rhizoma Rhei, Bulbus Lilii medicine are decocted with water to secondary, add for the first time 6 times of amounts of water, soak after 160 minutes, intense fire decocts boiling 10 minutes, use again slow fire boiling 45 minutes, filter to obtain decoction liquor for the first time.
2, the medicinal residues of filtration are added to 4 times of amounts of water, intense fire boils, then uses slow fire boiling 25 minutes, filters to obtain decoction liquor for the second time.
3, merge twice decoction liquor and get final product, medicinal liquid being divided into 4 doses and taking.
Medicine of the present invention has heat clearing away suppressing the hyperactive liver, the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and the function of tranquilizing by nourishing the heart, is used for the treatment of schizophrenia, short treating period, instant effect, has no side effect.
By test example, further set forth below the beneficial effect of medicine of the present invention, these test examples have comprised animal toxicity test report and the clinical observation material of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention
Get 30 of rabbit, male and female dual-purpose, body weight 2.0-2.5kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit activities, diet are normal, and medicine is without bad toxic and side effects.
The schizoid observations of [test example 2] Drug therapy of the present invention
1, physical data
Accept schizophrenic's totally 187 examples for medical treatment.
2, diagnostic criteria
(1) clinical manifestation
Schizoid clinical symptoms complexity is various, can relate to the aspects such as sensory perception, thinking, emotion, volitional behavior and cognitive function, and between individuality, symptom is widely different, even if same patient also may show different symptoms in different phase or stadium.
1. sensory perception obstacle: multiple sensory perception obstacle can appear in schizophrenia, the most outstanding sensory perception obstacle is hallucination, comprise auditory hallucination, photis, olfactory hallucination, gustatory hallucination and tactile hallucination etc., and auditory hallucination is the most common.
2. thought disturbance: thought disturbance is schizoid core symptom, mainly comprises form of thinking obstacle and content of thought obstacle.Form of thinking obstacle, take thinking associative process obstacle as main manifestations, comprises the obstacle of the aspects such as thinking association's active procedure (amount, speed and form), thinking association's continuity and logicality.Vain hope is the most common, most important content of thought obstacle.The vain hope the most often occurring has delusion of persecution, delusion of relation, delusion of influence, delusion of jealousy, the delusion of grandeur, non-descent delusion etc.According to estimates, there is delusion of persecution in the schizophrenic up to 80%, delusion of persecution can show as insecurity in various degree, as be monitored, be ostracised, worry to be offerd medicine or murdered etc., under vain hope impact, patient can make defence or aggression, in addition, passive experience is also comparatively outstanding with it at some patients were, thinking, emotion and behavior generation impact on patient.
3. affective disorder: apathy and emotional responses is inharmonious is the modal emotion symptom of schizophrenic, and in addition, the emotion symptoms such as incoordination excitement, irritability, depression and anxiety are also more common.
4. will and behavior disorder: the hypobulia of most of patients even lacks, show as movable minimizing, peel off and stay alone, behavior is passive, lack due enthusiasm and initiative, working and learning interest is gone down, be indifferent to future, to clearly not intending in the future, some patient may have some plans and plan, but seldom carries out.
5. cognitive dysfunction: the incidence rate of cognitive defect is high in schizophrenic, there is cognitive dysfunction in approximately 85% patient, as cognitive defects such as information processing and selective attention, working memory, short term memory and study, execution functions.Between cognitive defect symptom and other psychotic symptoms, there is certain dependency, as more obvious in the obvious patient's of form of thinking obstacle cognitive defect symptom, the obvious patient's of negative symptoms cognitive defect symptom is more obvious, and cognitive defect may be relevant with the generation of some positive symptom etc.Cognitive defect may betide psychotic symptoms clear before (as prodromal period), or sharply decline along with the appearance of psychotic symptoms, or along with the course of disease extends and progressively decline, tentatively think that Patients with Chronic Schizophrenia is more obvious than the cognitive defect of first episode schizophrenia.
(2) Clinical typing
1. intolerance style: this is in schizophrenia modal a type, take hallucination, vain hope as main clinical manifestation.
2. hebephrenictype: in adolescence morbidity, take significant thinking, emotion and behavior disorder as main manifestations, typical performance is loosening of association, splitting of thought, and emotion, behavior reaction naivety, may be with the hallucination of fragment, vain hope; It is hyperfunction that some patients were can show as instinctive action, as appetite, libido enhancing etc.This type patient first-episode age is low, and onset is anxious, and social function is impaired obviously, and general prognosis is not good.
3. catatonic type: take tension syndrome as main manifestations, patient can show as catatonic stupor, waxy flexibility, mechanical words and deeds, and incoordination psychomotor excitement, impulsive behavior.General this type patient onset is more anxious, and some patients were is alleviated rapidly.
4. simple type: this type is mainly in adolescence morbidity, the negative symptom of main manifestations, shrinks back as unsociable and eccentric, flat affect or indifferent etc.This type therapeutic effect is not good enough, and the decline of patient's social function is obvious, poor prognosis.
5. undifferentiated type: this type has the part feature of above-mentioned certain type, or there is above-mentioned various Some features, but be difficult to be included into above-mentioned any type.
6. Residual-type: this type is stage, the change that main manifestations is personality or the decline of social function after schizophrenia acute stage.
3, Therapeutic Method
Select above-mentioned medicament, to patient, take, each serving with 1 dose, every day early, respectively take 1 evening, within 10 days, is a course for the treatment of, takes continuously 6 courses for the treatment of.
4, efficacy assessment standard
Effective: the symptoms of schizophrenia disappears, observe half a year without bounce-back person;
Take a turn for the better: the symptoms of schizophrenia obviously improves, and body constitution progressively strengthens;
Invalid: the symptoms of schizophrenia, without change, does not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy schizophrenic's 187 examples of the present invention, effective 177 examples of result, obvious effective rate is 94.65%, 7 examples that take a turn for the better, and improvement rate is 3.74%, invalid 3 examples, total effective rate is 98.39%.
Claims (3)
1. the schizoid medicine for the treatment of, is characterized in that: it is to be made by the crude drug in following weight range:
Radix Gentianae 5-15 gram of Concha Ostreae 5-15 gram of Semen Persicae 5-15 gram
Lignum Aquilariae Resinatum 5-15 gram of pulvis ferri (ferrosic oxide) 25-35 gram of Fructus Alpiniae Oxyphyllae 10-20 gram
Exocarpium Citri Rubrum 5-15 gram of Massa Medicata Fermentata 5-15 gram of Semen Pruni 6-12 gram
Cortex Albiziae 5-15 gram of Ramulus Uncariae Cum Uncis 15-25 gram of Lapis Micae Aureus 15-25 gram
Scorpio 5-15 gram of Radix Achyranthis Bidentatae 10-20 gram of Flos Hibisci Mutabilis 10-20 gram
Caulis Bambusae In Taenia 10-20 gram of Folium Camelliae sinensis 1-10 gram of Rhizoma Zingiberis Recens 3-9 gram
Caulis Polygoni Multiflori 3-9 gram of Fructus Gardeniae 15-25 gram of Flos Inulae 5-15 gram
Radix Knoxiae 3-9 gram of Semen Arecae 5-15 gram of Fructus Tribuli 5-15 gram
Radix Salviae Miltiorrhizae 3-9 gram of Semen Sinapis Albae 3-9 gram of Semen Tritici aestivi 10-20 gram
Semen Pharbitidis 5-15 gram of Radix Polygoni Multiflori 5-15 gram of Semen Platycladi 6-12 gram
Radix Asparagi 5-15 gram of Radix Et Rhizoma Rhei 5-15 gram of Bulbus Lilii 5-15 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
10 grams, 10 grams of Semen Persicaes of 10 grams of Concha Ostreaes of Radix Gentianae
15 grams of 30 grams of Fructus Alpiniae Oxyphyllae of 10 grams of pulvis ferri (ferrosic oxide) of Lignum Aquilariae Resinatum
9 grams of 10 grams of Semen Prunis of 10 grams of Massa Medicata Fermentata of Exocarpium Citri Rubrum
20 grams of 20 grams of Lapis Micae Aureuses of 10 grams of Ramulus Uncariae Cum Uncis of Cortex Albiziae
15 grams of 15 grams of Flos Hibisci Mutabilis of 10 grams of Radix Achyranthis Bidentataes of Scorpio
6 grams, 5 grams of Rhizoma Zingiberis Recenss of 15 grams of Folium Camelliae sinensis of Caulis Bambusae In Taenia
10 grams of 20 grams of Flos Inulae of 6 grams of Fructus Gardeniaes of Caulis Polygoni Multiflori
10 grams of 10 grams of Fructus Tribulis of 6 grams of Semen Arecaes of Radix Knoxiae
15 grams of 6 grams of Semen Tritici aestivis of 6 grams of Semen Sinapis Albaes of Radix Salviae Miltiorrhizae
9 grams of 10 grams of Semen Platycladi of 10 grams of Radix Polygoni Multiflori of Semen Pharbitidis
10 grams of 10 grams of Bulbus Liliies of 10 grams of Radix Et Rhizoma Rhei of Radix Asparagi.
3. according to the preparation method of medicine described in claim 1 or 2, it is characterized in that: it comprises the following steps:
(1) get the raw materials ready
(1) Radix Gentianae: choose decontamination, remove residual stem, clean, run through rear cutting, dry;
(2) Concha Ostreae: clean, dry, pulverize use;
(3) Semen Persicae: remove duricrust impurity, put in boiling water pot and boil to the micro-wrinkle of crust, pull out, immerse in cold water, rub with the hands and remove seed coat, dry, winnow with a dustpan clean;
(4) Lignum Aquilariae Resinatum: outwash, be split into fritter, the used time smashs to pieces;
(5) pulvis ferri (ferrosic oxide): get the pulvis ferri (ferrosic oxide) of laying while forging iron, remove its coal soil impurity, clean, dry;
(6) Fructus Alpiniae Oxyphyllae: get Fructus Alpiniae Oxyphyllae and put in pot, fry to shell burned blackly, take out coldly, remove shell, get core and smash use to pieces;
(7) Exocarpium Citri Rubrum: choose decontamination, outwash, used time folding is broken;
(8) Massa Medicata Fermentata: get wheat bran and sprinkle evenly in heat pot, the cigarette of having waited, pours Massa Medicata Fermentata into, fries to yellow, takes out, and sieve removes wheat bran, cools;
(9) Semen Pruni: sieve removes spare, washes in a pan only, chooses clean impurity and broken shell, dries, and the used time smashs to pieces;
(10) Cortex Albiziae: clear water soaks to be cleaned, and pulls out, is first divided into after moistening and equates large rectangular, then stripping and slicing or shredding, dry;
(11) Ramulus Uncariae Cum Uncis: choose old stalk, impurity, clean, dry;
(12) Lapis Micae Aureus: remove impurity, break into fragment;
(13) Scorpio: clear water floats the matter that desalts, dries, or low baking temperature roasting is used;
(14) Radix Achyranthis Bidentatae: choose decontamination, clean, soften, go reed, cutting, dries;
(15) Flos Hibisci Mutabilis: remove impurity, dry;
(16) Caulis Bambusae In Taenia: remove hard bamboo let, impurity, shake off ash bits, be kneaded into little group or cutting;
(17) Folium Camelliae sinensis: after fresh leaf gathers, through completing, knead the dry green tea of making;
(18) Rhizoma Zingiberis Recens: choose decontamination, clean earth, used time section;
(19) Caulis Polygoni Multiflori: clear water is cleaned, slightly soaks, and pulls out, and after running through, cutting, dries;
(20) Fructus Gardeniae: sieve dedust bits, choose decontamination, pulverize and sieve or cut off two ends;
(21) Flos Inulae: choose clean impurity, except destemming leaf, sieve removes earth;
(22) Radix Knoxiae: remove impurity, clean, run through, cut sheet or section, dry, sieve removes chip;
(23) Semen Arecae: choose decontamination, soak with clear water, change water by temperature situation, till soaking, pick up, section, dries;
(24) Fructus Tribuli: float silt, the hard thorn that Ex-all is residual;
(25) Radix Salviae Miltiorrhizae: choose clean impurity, remove rhizome, clean, pull out, run through rear section, dry;
(26) Semen Sinapis Albae: the former medicine most impurity of winnowing with a dustpan, fry to buff, micro-have fragrance and get final product;
(27) Semen Tritici aestivi: choose decontamination, winnow with a dustpan and only dry;
(28) Semen Pharbitidis: get crude drug, remove impurity, flat grain and shell, the used time smashs to pieces;
(29) Radix Polygoni Multiflori: choose decontamination, clean, saturating with blister to eighty per cant, to pull out, profit is even to inside and outside humidity, and section or dice, dry;
(30) Semen Platycladi: choose clean impurity, remove residual shell and seed coat;
(31) Radix Asparagi: choose decontamination, water is cleaned, and moistening is even to inside and outside humidity, cutting, dry;
(32) Radix Et Rhizoma Rhei: choose clean impurity, big or small stepping, stewing profit is even to inside and outside humidity, cuts into slices or is cut into small pieces, dries;
(33) Bulbus Lilii: choose decontamination, black lobe, the ash disposal of winnowing with a dustpan bits;
(2) preparation
(1) by the Radix Gentianae of described weight, Concha Ostreae, Semen Persicae, Lignum Aquilariae Resinatum, pulvis ferri (ferrosic oxide), Fructus Alpiniae Oxyphyllae, Fructus Citri tangerinae is red, Massa Medicata Fermentata, Semen Pruni, Cortex Albiziae, Ramulus Uncariae Cum Uncis, Lapis Micae Aureus, Scorpio, Radix Achyranthis Bidentatae, Flos Hibisci Mutabilis, Caulis Bambusae In Taenia, Folium Camelliae sinensis, Rhizoma Zingiberis Recens, Caulis Polygoni Multiflori, Fructus Gardeniae, Flos Inulae, Radix Knoxiae, Semen Arecae, Fructus Tribuli, Radix Salviae Miltiorrhizae, Semen Sinapis Albae, Semen Tritici aestivi, Semen Pharbitidis, Radix Polygoni Multiflori, Semen Platycladi, Radix Asparagi, Radix Et Rhizoma Rhei, Bulbus Lilii medicine decocts with water secondary, add for the first time 6 times of amounts of water, soak after 160 minutes, intense fire decocts boiling 10 minutes, use again slow fire boiling 45 minutes, filter to obtain decoction liquor for the first time,
(2) medicinal residues of filtration are added to 4 times of amounts of water, intense fire boils, then uses slow fire boiling 25 minutes, filters to obtain decoction liquor for the second time;
(3) merge twice decoction liquor and get final product.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105664055A (en) * | 2016-03-12 | 2016-06-15 | 李传玲 | Traditional Chinese medicine composition for treating psychosis |
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| CN1179959A (en) * | 1997-07-30 | 1998-04-29 | 刘风森 | Chinese patent drug |
| CN102755592A (en) * | 2012-07-03 | 2012-10-31 | 王伏兰 | Traditional Chinese medicine preparation for treating schizophrenia |
| CN102772554A (en) * | 2012-08-03 | 2012-11-14 | 西安市精神卫生中心 | Traditional Chinese medicine compound for curing schizophrenia |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1179959A (en) * | 1997-07-30 | 1998-04-29 | 刘风森 | Chinese patent drug |
| CN102755592A (en) * | 2012-07-03 | 2012-10-31 | 王伏兰 | Traditional Chinese medicine preparation for treating schizophrenia |
| CN102772554A (en) * | 2012-08-03 | 2012-11-14 | 西安市精神卫生中心 | Traditional Chinese medicine compound for curing schizophrenia |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105664055A (en) * | 2016-03-12 | 2016-06-15 | 李传玲 | Traditional Chinese medicine composition for treating psychosis |
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